Victorian Heart Institute (VHI)

Projects

Projects per year 2020 2020 2021 2036

• 3 Not started
• 6 Curtailed
• 58 Active
• 183 Finished

Projects per year

Search results

• Active

  Precision prevention of cardiovascular disease using genomic risk stratification

  Yu, C., Lacaze, P., Nicholls, S. & McNeil, J.

  1/01/25 → 31/12/26

  Project: Research

• Randomized comparison of the clinical Outcome of single versus Multiple Arterial grafts: the ROMA trial

  Bennetts, J. & Perry, L.

  12/11/24 → 31/12/36

  Project: Research

• A Phase 3, Open-label Extension Study to Evaluate the Safety and Efficacy of MK-0616 in Adults With Hypercholesterolemia

  Nicholls, S.

  12/11/24 → 8/07/25

  Project: Research

• CORE - Open-Label Extension Study of Olezarsen (ISIS 678354) Administered Subcutaneously to Patients with Severe Hypertriglyceridemia (SHTG)

  Nicholls, S.

  1/11/24 → 1/03/25

  Project: Research

• Evaluation of the Safety and Performance of the Ladera Medical Suture-Mediated Large Bore Closure (LBC) System

  Gooley, R.

  30/09/24 → 28/02/25

  Project: Research

• BalanceD-HF: A Phase III, Randomised, Double-blind Study to Evaluate the Effect of Balcinrenone/Dapagliflozin, Compared with Dapagliflozin, on the Risk of Heart Failure Events and Cardiovascular Death in Patients with Heart Failure and Impaired Kidney Function RES (BalanceD-HF)

  Rao, S.

  25/07/24 → 12/10/26

  Project: Research

• A Randomized, Double-blind, Placebo-controlled Clinical Study to Evaluate Mavacamten in Adolescents (age 12 years to < 18 years) with Symptomatic Obstructive Hypertrophic Cardiomyopathy.

  Horton, A.

  17/07/24 → 15/04/28

  Project: Research

• Impact of in-utero exposure to infection on HOMER1 isoforms and the risk of autism

  Cota Coronado, A. C., Hill, R. & Sundram, S.

  17/06/24 → 21/11/25

  Project: Research

• A Phase 3, Randomized, Double-Blind, Placebo-Controlled Study to Investigate the Effect of Lepodisiran on the Reduction of Major Adverse Cardiovascular Events in Adults with Elevated Lipoprotein(a) who have Established Atherosclerotic Cardiovascular Disease or Are at Risk for a First Cardiovascular Event – ACCLAIM-Lp(a)

  Nicholls, S.

  24/05/24 → 23/05/29

  Project: Research

• A Phase 1 Open-label, Multicenter, First-in-human, Ascending Single Dose Study Evaluating the Safety and Tolerability of a Lipid Nanoparticle Formulation of CRISPR–Guide RNA–Cas9 Nuclease (CTX320) for In Vivo Editing of the Apolipoprotein(a) Gene (LPA) in Subjects with Elevated Lipoprotein(a) and a History of Atherosclerotic Cardiovascular Disease or Calcific Aortic Valve Stenosis

  Nicholls, S.

  10/04/24 → 9/04/29

  Project: Research

• A Phase 3, randomised, double-blind, parallel-group, event-driven, cardiovascular safety study with BI 456906 administered subcutaneously compared with placebo in participants with overweight or obesity with established cardiovascular disease (CVD) or chronic kidney disease, and/or at least two weight-related complications or risk factors for CVD.

  Nicholls, S.

  21/03/24 → 20/03/29

  Project: Research

• Establishing Robust Tandem Stenosis with Advanced Safety Enhancements by Using 3D Printing to Revolutionise Stenosis Generation

  Chen, B.

  1/01/24 → 26/12/26

  Project: Research

• Development of PET-CT imaging in mouse models to screen for new anti-inflammatory therapies

  Bubb, K., Chen, B., Karunakaran, D. & Thomas, J.

  Monash University – Internal Department Contribution

  1/01/24 → 31/12/25

  Project: Research

• Targeting macrophage necroptosis in vulnerable plaques

  Karunakaran, D.

  1/01/24 → 31/12/25

  Project: Research

• Characteristics and treatment patterns of heart failure patients with Reduced ejection fraction in Australia (CHEERS-HF)

  Nicholls, S. & Nelson, A.

  Boehringer Ingelheim (Australia)

  9/11/23 → 9/03/25

  Project: Research

• A Phase 1 Open-label, Multicenter, First-in-human, Ascending Single-dose Study Evaluating the Safety and Tolerability of a Lipid Nanoparticle Formulation of CRISPR-Guide RNA–Cas9 Nuclease (CTX310) for In Vivo Editing of the Angiopoietin-like 3 (ANGPTL3) Gene in Subjects With Refractory Dyslipidemias

  Nicholls, S.

  1/11/23 → 2/11/28

  Project: Research

• Intervene Medical Pty Ltd - QFR corelab

  Nicholls, S. & Wong, D.

  Intervene Medical Pty Ltd

  15/08/23 → 30/09/25

  Project: Research

• MitoHOPE: Introducing Mitochondrial Donation in AustraliaL The MitoHOPE (Healthy Outcomes Pilot and Evaluation) Program

  Carroll, J., Herbert, M., Christodoulou, J., Thorburn, D. R., Mills, C., Zander-Fox, D. L., Robker, R., Rombauts, L., Sallevelt, S., Ludlow, K., Coman, D. J., Ellaway, C. J., Mackey, D. A., Delatycki, M. B., Yau, W. Y., Tchan, M. C., Long, J. C., Hardy, T., Adhikari, D., Choudhary, M., Hyslop, L. A., Mann, J., Ryan, M., Hodges, R., Hui, L., Kamien, B. A., Mallett, A. J., Semsarian, C., Wallis, M. J., Wall, M., Zoungas, S., Goranitis, I., Gyngell, C., Hammarberg, K., Sparrow, R., Warren, N., Fahey, M., Stutterd, C. A., Schweitzer, D., McGillivray, G., Savulescu, J., Panetta, J., Kava, M. P., Freckmann, M., Lynch, M., Lamont, P. J., Scott, R., Ware, T., Mowat, D., Jones, K. J., Green, S., Wolfe, R., Hackett, A., Bratkovic, D., Horton, A. & Blok, R.

  Monash University – Internal Faculty Contribution, Australian Genomics, Centenary Institute of Cancer Medicine & Cell Biology, James Cook University, Lyons Eye Institute Limited, Macquarie University, Murdoch Children's Research Institute, Australian Mitochondrial Disease Foundation Limited (trading as Mito Foundation), Monash IVF Group Limited, Perron Institute for Neurological and Translational Science Limited, Queensland Children’s Hospital, Tasmanian Clinical Genetics Service, University of Adelaide, Victorian Assisted Reproductive Treatment Authority (VARTA) (Victoria), Women's and Children's Health Care Network Incorporated, Western Sydney Local Health District (WSLHD)

  1/06/23 → 31/05/28

  Project: Research

• A digital health intervention to provide individualised feedback on pathology requesting practices of Emergency Department clinicians

  Craig, S., Taniar, D., Haryanto, A., O'Reilly, G., Callander, E., Buntine, P., Egerton-Warburton, D., Babl, F. E. & Blecher, G.

  Department of Health and Aged Care (Australia)

  28/04/23 → 30/06/25

  Project: Research

• ASCERTAIN: AtheroSclerotic Cardiovascular disEase Risk assessmenT and treAtment In AustraliaN primary care

  Nicholls, S.

  1/02/23 → 31/01/25

  Project: Research

• A national critical care research platform to ensure high-quality sepsis care in Australian ICU’s

  Udy, A., McQuilten, Z., Saxena, M. K., Serpa Neto, A., Higgins, L., Delaney, A., Eastwood, G., Jones, D., Shekar, K., Hammond, N. E., Thompson, K., Litton, E., Young, P., Haines, K., Deane, A., Bellomo, R., Cooper, J., Hodgson, C., Webb, S., Cohen, J., French, C. J., Peake, S., Pilcher, D., Campbell, L. T. & Finfer, S. R.

  Department of Health and Aged Care (Australia)

  1/02/23 → 31/01/28

  Project: Research

• Advancing Preclinical Development of Novel GPCR-targeted Therapeutics for Heart Failure

  Ritchie, R., Figtree, G., Qin, C. H., May, L., Nicholls, S., Taylor, A., Yang, J. Y. H., Shackleford, D., Schiattarella, G., Pinto, A., Drummond, G., Horowitz, J. D., Bubb, K., Ng, H. H., Vecchio, L., Nelson, A., Kirkpatrick, C., McDonald, C., Febbraio, M., Vinh, A., Odiba, J., Brown, H. & Stupple, P.

  1/02/23 → 31/01/26

  Project: Research

• A Phase 2 Open-Label Extension Study To Evaluate The Long-Term Safety And Efficacy of ARO-APOC3 In Adults with Dyslipidemia

  Nicholls, S.

  1/09/22 → 31/08/27

  Project: Research

• A Randomized, Double-Blind, Placebo-Controlled, Phase 3 Study of ISIS 678354 Administered Subcutaneously to Patients with Severe Hypertriglyceridemia

  Nicholls, S.

  25/08/22 → 24/08/27

  Project: Research

• Atheroma Progression in Clonal Haematopoiesis Investigation with iMaging, biomarkers and Genomic Sequencing (ARCHIMEDES)

  Nicholls, S., Bubb, K., Southey, M., Nelson, A., Milne, R., Nerlekar, N., Shortt, J., Hughes, T. P., Breen, J., Sargeant, T. J. & Zoungas, S.

  1/06/22 → 31/05/25

  Project: Research

• HIP4Hips: Intensive physiotherapy to lower hospital length of stay after hip fracture

  Holland, A., Kimmel, L., Harris, I. A., Ackerman, I., Page, R., Naylor, J. M., Burge, A., Armstrong, E., Gordon, I., Somerville, L., Gabbe, B., Ekegren, C., Harris, A., Woode, M. E. & Hepworth, G.

  14/04/22 → 7/09/25

  Project: Research

• ZEUS - Effects of ziltivekimab versus placebo on cardiovascular outcomes in participants with established atherosclerotic cardiovascular disease, chronic kidney disease and systemic inflammation

  Nicholls, S. & Kerr, P.

  27/01/22 → 26/01/27

  Project: Research

• ASHRA: Australian Stroke and Heart Research Accelerator (ASHRA)

  Nicholls, S., Kovacic, J. C., Zoungas, S., Neal, B. C., Chow, C., Figtree, G., Campbell, B. C. V., Maple-Brown, L. J., Brown, A., Hayward, C. S., Hill, A., Hool, L. C., Currie, P., Rodgers, A., Arnott, C., Wu, J. H. Y., Kritharides, L., Ugander, M., Chiang, J., Davis, S. M., Donnan, G. A., Yan, B., Barr, E. L. M., Breen, J., Barclay, J., Brown, H., Correa, M., Wu, C., Butters, J., Glass, P., Ritchie, R., Vandenburg, J., Patel, A., Semsarian, C., Martino, M., Laranjo, L., Thiagalingam, A., Sivagangabalan, G., Fox, K., Rice, H., Ali, M., Francisco, J., Dawidowska, I. & Greenway, A.

  10/01/22 → 15/02/26

  Project: Research

• Reprograming of different cell types into podocytes

  Polo, J., Bertram, J., Rackham, O., Meagher, L. & Ruka, D.

  3/01/22 → 12/01/26

  Project: Research

• A Double-blind, Placebo-controlled Phase 2b Study to Evaluate the efficacy and safety of ARO-APOC3 in Adults with Mixed Dyslipidemia

  Nicholls, S.

  25/11/21 → 24/11/26

  Project: Research

• Engineering in vitro tissue microenvironments

  Bray, L., Haupt, L., Subramaniam, N., Risbridger, G., Werner, C., Meagher, L. & Ruka, D.

  1/04/21 → 1/10/25

  Project: Research

• A Phase 2, Double-Blind, Randomized, Placebo-Controlled Study to Evaluate the Effect of RBT-1 on Preconditioning Response Biomarkers in Subjects Undergoing Coronary Artery Bypass Graft (CABG) and/or Cardiac Valve Surgery (the START Study)

  Smith, J.

  23/02/21 → 22/02/26

  Project: Research

• GooD4Mums: A randomised controlled implementation trial to reduce conversion from gestational diabetes to type 2 diabetes in general practice

  Teede, H., Dunbar, J. A., Boyle, D., Versace, V. L., Speight, J., Lim, S., Morgan, M. A. J., O'Reilly, S. L., ford, D., Callander, E., Hendrieckx, C., McNamara, K., Morrison, M. K., Johnson, G., Bennett, C. & Licqurish, S.

  National Health and Medical Research Council (NHMRC) (Australia)

  1/02/21 → 31/01/26

  Project: Research

  File

• In vivo assessment of BoneFlo® system in an ovine model of tibial critical-sized defect

  Saifzadeh, S., Hutmacher, D. W., Bray, L., Steck, R., Schumann, D., Meagher, L. & Ruka, D.

  Queensland University of Technology (QUT)

  13/01/21 → 13/01/26

  Project: Research

• ARC Training Centre for Cell and Tissue Engineering Technologies

  Meagher, L., Bray, L., Voelcker, N., Risbridger, G., Hutmacher, D. W., Batra, J., Dargaville, T., Elnathan, R., Saifzadeh, S., Heng, T., Aguilar, M., Lim, R., Klein, T. J., Fisher, A., McGovern, J., Dislakis, V., McLellan, A., Dulleck, U., Steck, R., Scott, W., Corrie, S., Thissen, H., Cameron, N., Haupt, L. M., Werner, C., Levett, P., Whyte, S., Forsythe, J., Smith, N., Frith, J., Hicks, C., Rackham, O. J. L., Sohal, A., Polo, J., May, M., Reimers, N., Toh, Y., McKee, J., Adams, M., Obschonka, M., Subramaniam, N., Yambem, S. D., Russell-Bennett, R., Bertram, J., Schierjott, R., Hollands, J., Currie, P., Ball, G., Trapani, J. A., Cadarso Busto, V., Loessner, D., Ecker, R., Boyd, R. L. & Lim, J.

  Australian Research Council (ARC), PolVax Pty Ltd, Cartherics Pty Ltd, TissueGUARD GmbH, Peter MacCallum Cancer Centre, TissueGnostics GmbH

  13/01/21 → 30/11/27

  Project: Research

• Optimise primary aldosteronism detection for better health outcomes

  Yang, J.

  Department of Health and Aged Care (Australia)

  1/01/21 → 31/12/25

  Project: Research

• Understanding the role of light exposure in individual differences in the circadian response to shift work

  Sletten, T., Wilson Rajaratnam, S., Lockley, S., Postnova, S. D., Howard, M. E. & Facer-Childs, E.

  1/01/21 → 31/12/25

  Project: Research

• Increasing osteoporosis treatment uptake

  Ebeling, P.

  National Health and Medical Research Council (NHMRC) (Australia)

  1/01/21 → 31/12/25

  Project: Research

• Optimising engagement in cardiac secondary prevention: a health literacy approach

  Beauchamp, A.

  1/01/21 → 31/12/25

  Project: Research

• ARC Training Centre for Green Chemistry in Manufacturing

  Patti, A., Junkers, T., Raston, C. L., Barrow, C. J., Hapgood, K., Gates, W. P., Adcock, J. L., Sutti, A., Rajkhowa, R., Saito, K., Tabor, R., Hearn, M., Tanksale, A., Garnier, G., Franco, C., Tang, Y., Zhang, W., Heimann, K., Crawford, S., Height, M., Cock, B., Warner, J. C., Buckingham, E., King, B., Jayaratne, V., Scott, J. L., Bury, P., Chan, P. W. H., Robinson, A., Semple, J., Smullen, R., Ciampi, S., Chong, J., Miltenoff, J., Moreno , C., Innes, L., Aldrich, C., Lovelady, C., James, I., Phillips, D., Pham, H., Sacher, M., Woods, R., Francis, P., Pas, E., Wood, B., Sun, B., Blair, V., Sastry, M., Dowley, A., McCann, K., Albijanic, B., James, I. & Little, K.

  Infineum International Limited (United Kingdom), Plantworx Pty Ltd, Green Eco Technologies (Australia) Pty Ltd, Trustee for Steven Mantzaris Family Trust, CSL Behring (Australia), Bioworks Australia Pty Ltd (trading as Bioworks Australia), Australian Research Council (ARC), BOC Australia Pty Limited, Phytovision Pty Ltd, Beyond Benign

  15/12/20 → 14/12/25

  Project: Research

• EV ICD Pivotal Study

  Kotschet, E.

  25/11/20 → 24/11/25

  Project: Research

• EV ICD Pilot Study

  Kotschet, E.

  25/11/20 → 24/11/25

  Project: Research

• The COlchicine for COronary Plaque MOdification in Acute Coronary Syndrome Study. COCOMO-ACS Study.

  Wong, D.

  18/11/20 → 17/11/25

  Project: Research

• NHMRC Centre of Research Excellence for Better Outcomes in Coronary Artery Disease

  Figtree, G., Nicholls, S., Chow, C., Grieve, S. M., Brown, A., Jenkins, A., Karlheinz, P., Psaltis, P. J., Yang, J. Y. H. & Meikle, P. J.

  1/11/20 → 31/10/25

  Project: Research

• ASCEND: ASCEND (ARDS in Children and ECMO initiation strategies impact on Neuro-Development).

  Barbaro, R. & Hodgson, C.

  5/09/20 → 30/06/25

  Project: Research

  File

• Formyl peptide receptor biased agonists as novel cardioprotective agents against myocardial infarction.

  Vecchio, L.

  25/08/20 → 30/06/28

  Project: Research

• A randomized double-blind, placebo-controlled, multicenter trial assessing the impact of lipoprotein(a) lowering with TQJ230 on major cardiovascular events in patients with established cardiovascular disease

  Nicholls, S.

  7/07/20 → 6/07/25

  Project: Research

• The Effect of Tirzepatide versus Dulaglutide on Major Adverse Cardiovascular Events in Patients with Type 2 Diabetes (SURPASS-CVOT)

  Nicholls, S.

  2/06/20 → 1/06/25

  Project: Research

• Using Polygenic Risk Scores to Target Statin Therapy in Primary Prevention

  Nicholls, S., Semsarian, C., Wong, D., Zoungas, S., Ingles, J. & Nelson, A.

  1/06/20 → 30/03/25

  Project: Research

• Healthy lifestyle in Preconception, Pregnancy and Postpartum - HiPPPP- Personalised Medicine meets Public Health in the first 2000 days

  Teede, H., Skouteris, H., Boyle, J., Moran, L., Norman, R. J., Hills, A. P., Ademi Delaney, Z., Dunbar, J. A., Thangaratinam, S. & Enticott, J.

  1/06/20 → 31/05/26

  Project: Research