Research Output 1986 2019

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2019

Adrenoceptor regulation of the mechanistic target of rapamycin in muscle and adipose tissue

Chia, L. Y., Evans, B., Mukaida, S., Bengtsson, T., Hutchinson, D. & Sato, M., 1 Jul 2019, In : British Journal of Pharmacology. 176, 14, p. 2433-2448 16 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

Open Access
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G-Protein–Coupled Receptors Are Dynamic Regulators of Digestion and Targets for Digestive Diseases

Canals, M., Poole, D. P., Veldhuis, N. A., Schmidt, B. L. & Bunnett, N. W., 1 May 2019, In : Gastroenterology. 156, 6, p. 1600-1616 17 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

Light-activated chimeric GPCRs: limitations and opportunities

Tichy, A-M., Gerrard, E. J., Sexton, P. M. & Janovjak, H., 1 Aug 2019, In : Current Opinion in Structural Biology. 57, p. 196-203 8 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

Localised GPCR signalling as revealed by FRET biosensors

Halls, M. L., 1 Apr 2019, In : Current Opinion in Cell Biology. 57, p. 48-56 9 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

Relaxin and extracellular matrix remodeling: Mechanisms and signaling pathways

Ng, H. H., Shen, M., Samuel, C. S., Schlossmann, J. & Bennett, R. G., 1 May 2019, In : Molecular and Cellular Endocrinology. 487, p. 59-65 7 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

Relaxin and fibrosis: Emerging targets, challenges, and future directions

Kanai, A. J., Konieczko, E. M., Bennett, R. G., Samuel, C. S. & Royce, S. G., 1 May 2019, In : Molecular and Cellular Endocrinology. 487, p. 66-74 9 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

Self-assembling injectable peptide hydrogels for emerging treatment of ischemic stroke

Hong, A., Aguilar, M-I., Del Borgo, M. P., Sobey, C. G., Broughton, B. R. S. & Forsythe, J. S., 2019, In : Journal of Materials Chemistry B. 7, 25, p. 3927-3943 17 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

Signalling in response to sub-picomolar concentrations of active compounds: Pushing the boundaries of GPCR sensitivity

Civciristov, S. & Halls, M. L., Jul 2019, In : British Journal of Pharmacology. 176, 14, p. 2382-2401 20 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

The adenosine A 2B G protein-coupled receptor: Recent advances and therapeutic implications

Vecchio, E. A., White, P. J. & May, L. T., 1 Jan 2019, In : Pharmacology and Therapeutics. 198, p. 20-33 14 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

Understanding relaxin signalling at the cellular level

Valkovic, A. L., Bathgate, R. AD., Samuel, C. S. & Kocan, M., 1 May 2019, In : Molecular and Cellular Endocrinology. 487, p. 24-33 10 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

2018

Amnion epithelial cells - A novel therapy for ischemic stroke?

Evans, M. A., Broughton, B. R. S., Drummond, G. R., Ma, H., Phan, T. G., Wallace, E. M., Lim, R. & Sobey, C. G., 1 Aug 2018, In : Neural Regeneration Research. 13, 8, p. 1346-1349 4 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

Open Access
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Beyond gut feelings: How the gut microbiota regulates blood pressure

Marques, F. Z., Mackay, C. R. & Kaye, D. M., 1 Jan 2018, In : Nature Reviews Cardiology. 15, 1, p. 20-32 13 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

Biased agonism and allosteric modulation of metabotropic glutamate receptor 5

Trinh, P. N. H., May, L. T., Leach, K. & Gregory, K. J., 15 Nov 2018, In : Clinical science (London, England : 1979). 132, 21, p. 2323-2338 16 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

Open Access
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Genetically Encoded FRET Biosensors to Illuminate Compartmentalised GPCR Signalling

Halls, M. L. & Canals, M., 1 Feb 2018, In : Trends in Pharmacological Sciences. 39, 2, p. 148-157 10 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

G protein–coupled receptors targeting insulin resistance, obesity, and type 2 diabetes mellitus

Riddy, D. M., Delerive, P., Summers, R. J., Sexton, P. & Langmead, C. J., 1 Jan 2018, In : Pharmacological Reviews. 70, 1, p. 39-67 29 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

Insights into endotoxin-mediated lung inflammation and future treatment strategies

Chakraborty, A., Boer, J. C., Selomulya, C., Plebanski, M. & Royce, S. G., 2 Nov 2018, In : Expert Review of Respiratory Medicine. 12, 11, p. 941-955 15 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

Mechanisms of signalling and biased agonism in G protein-coupled receptors

Wootten, D. L., Christopoulos, A., Marti-Solano, M., Babu, M. M. & Sexton, P. M., Oct 2018, In : Nature Reviews Molecular Cell Biology. 19, 10, p. 638-653 16 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

Open Access
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New paradigms in adenosine receptor pharmacology: allostery, oligomerization and biased agonism

Vecchio, E. A., Baltos, J. A., Nguyen, A. T. N., Christopoulos, A., White, P. J. & May, L. T., 1 Nov 2018, In : British Journal of Pharmacology. 175, 21, p. 4036-4046 11 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

Peripheral modulation of the endocannabinoid system in metabolic disease

Shrestha, N., Cuffe, J. S. M., Hutchinson, D. S., Headrick, J. P., Perkins, A. V., McAinch, A. J. & Hryciw, D. H., 1 Mar 2018, In : Drug Discovery Today. 23, 3, p. 592-604 13 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

Rules of Engagement: GPCRs and G Proteins

Glukhova, A., Draper-Joyce, C. J., Sunahara, R. K., Christopoulos, A., Wootten, D. L. & Sexton, P. M., 7 Sep 2018, In : ACS Pharmacology and Translational Sciences. 1, 2, p. 73-83 11 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

Structural insights into G-protein-coupled receptor allostery

Thal, D. M., Glukhova, A., Sexton, P. M. & Christopoulos, A., 5 Jul 2018, In : Nature. 559, 7712, p. 45-53 9 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

2017

Adenylyl cyclase signalling complexes - pharmacological challenges and opportunities

Halls, M. L. & Cooper, D. M. F., Apr 2017, In : Pharmacology and Therapeutics. 172, p. 171-180 10 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

File

A kinetic view of GPCR allostery and biased agonism

Lane, J. R., May, L. T., Parton, R. G., Sexton, P. M. & Christopoulos, A., 18 Aug 2017, In : Nature Chemical Biology. 13, 9, p. 929-937 9 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

Open Access
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Allosteric modulation as a unifying mechanism for receptor function and regulation

Changeux, J-P. & Christopoulos, A., 1 Sep 2017, In : Diabetes, Obesity and Metabolism. 19, p. 4-21 18 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

Open Access
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Allostery and Biased Agonism at Class B G Protein-Coupled Receptors

Wootten, D., Miller, L. J., Koole, C., Christopoulos, A. & Sexton, P. M., 11 Jan 2017, In : Chemical Reviews. 117, 1, p. 111-138 28 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

Amyloidogenicity at a Distance: How Distal Protein Regions Modulate Aggregation in Disease

Lucato, C. M., Lupton, C. J., Halls, M. L. & Ellisdon, A. M., 5 May 2017, In : Journal of Molecular Biology. 429, 9, p. 1289-1304 16 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

File

Antivenom for neuromuscular paralysis resulting from snake envenoming

Silva, A., Hodgson, W. C. & Isbister, G. K., 19 Apr 2017, In : Toxins. 9, 4, 17 p., 143.

Research output: Contribution to journalReview ArticleResearchpeer-review

Open Access
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A portrait of the sialyl glycan receptor specificity of the H10 influenza virus hemagglutinin—a picture of an avian virus on the verge of becoming a pandemic?

Schneider, E. K., Li, J. & Velkov, T., 13 Dec 2017, In : Vaccines. 5, 4, 15 p., 51.

Research output: Contribution to journalReview ArticleResearchpeer-review

Factors Responsible for Obesity-Related Hypertension

Lim, K., Jackson, K. L., Sata, Y. & Head, G. A., 1 Jul 2017, In : Current Hypertension Reports. 19, 7, 10 p., 53.

Research output: Contribution to journalReview ArticleResearchpeer-review

Molecular insights into allosteric modulation of Class C G protein-coupled receptors

Leach, K. & Gregory, K. J., 1 Feb 2017, In : Pharmacological Research. 116, p. 105-118 14 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

Novel approaches for treating hypertension

Freeman, A. J., Vinh, A. & Widdop, R. E., 27 Jan 2017, In : F1000Research. 6, 7 p., 80.

Research output: Contribution to journalReview ArticleResearchpeer-review

Open Access
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Targeting adenosine receptors for the treatment of cardiac fibrosis

Vecchio, E. A., White, P. J. & May, L. T., 5 May 2017, In : Frontiers in Pharmacology. 8, MAY, 7 p., 243.

Research output: Contribution to journalReview ArticleOtherpeer-review

Open Access
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The actions of relaxin on the human cardiovascular system

Sarwar, M., Du, X. J., Dschietzig, T. B. & Summers, R. J., 1 May 2017, In : British Journal of Pharmacology. 174, 10, p. 933-949 17 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

The opposing roles of NO and oxidative stress in cardiovascular disease

Ritchie, R. H., Drummond, G. R., Sobey, C. G., De Silva, T. M. & Kemp-Harper, B. K., Feb 2017, In : Pharmacological Research. p. 57-69 13 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

2016

Allosteric Modulation as a Unifying Mechanism for Receptor Function and Regulation

Changeux, J. P. & Christopoulos, A., 25 Aug 2016, In : Cell. 166, 5, p. 1084-1102 19 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

Antifibrotic actions of Serelaxin: New roles for an old player

Samuel, C. S., Summers, R. J. & Hewitson, T. D., Jun 2016, In : Trends in Pharmacological Sciences. 37, 6, p. 485-497 13 p.

Research output: Contribution to journalReview ArticleOtherpeer-review

Caveolae: A role in endothelial inflammation and mechanotransduction?

Shihata, W. A., Michell, D. L., Andrews, K. L. & Chin-Dusting, J. P. F., 20 Dec 2016, In : Frontiers in Physiology. 7, 9 p., 628.

Research output: Contribution to journalReview ArticleResearchpeer-review

Open Access
File

Cerebral small vessel disease: Targeting oxidative stress as a novel therapeutic strategy?

De Silva, T. M. & Miller, A. A., 17 Mar 2016, In : Frontiers in Pharmacology. 7, 18 p., 61.

Research output: Contribution to journalReview ArticleOtherpeer-review

Open Access
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Effects of animal venoms and toxins on hallmarks of cancer

Chaisakul, J., Hodgson, W. C., Kuruppu, S. & Prasongsook, N., 15 Jul 2016, In : Journal of Cancer. 7, 11, p. 1571-1578 8 p.

Research output: Contribution to journalReview ArticleOtherpeer-review

G protein coupled receptor 18: a potential role for endocannabinoid signaling in metabolic dysfunction

Rajaraman, G., Simcocks, A., Hryciw, D. H., Hutchinson, D. S. & McAinch, A. J., 1 Jan 2016, In : Molecular Nutrition and Food Research. 60, 1, p. 92-102 11 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

Microvascular dysfunction and cognitive impairment

De Silva, T. M. & Faraci, F. M., 17 Mar 2016, In : Cellular and Molecular Neurobiology. 36, 2, p. 241-258 18 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

Multivalent approaches and beyond: novel tools for the investigation of dopamine D2 receptor pharmacology

Kopinathan, A., Scammells, P. J., Lane, J. R. & Capuano, B., 1 Jul 2016, In : Future Medicinal Chemistry. 8, 11, p. 1349-1372 24 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

Relationships between adult asthma and oxidative stress markers and pH in exhaled breath condensate: A systematic review

Aldakheel, F. M., Thomas, P. S., Bourke, J. E., Matheson, M. C., Dharmage, S. C. & Lowe, A. J., Jun 2016, In : Allergy. 71, 6, p. 741-757 17 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

2014

The class B G-protein-coupled GLP-1 receptor: an important target for the treatment of type-2 diabetes mellitus

Miller, L. J., Sexton, P. M., Dong, M. & Harikumar, K. G., 2014, In : International Journal of Obesity. 4, p. S9-S13 5 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

2013

The role of ghrelin in neuroprotection after ischemic brain injury

Spencer, S. J., Miller, A. A. & Andrews, Z. B., 1 Jan 2013, In : Brain Sciences. 3, 1, p. 344-359 16 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

2009

Orthosteric/allosteric bitopic ligands going hybrid with GPCRs

Valant, C., Sexton, P. M. & Christopoulos, A., 1 Jun 2009, In : Molecular Interventions. 9, 3, p. 125-135 11 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

2002

The pharmacological activity of fish venoms

Church, J. E. & Hodgson, W. C., 27 Aug 2002, In : Toxicon. 40, 8, p. 1083-1093 11 p.

Research output: Contribution to journalReview ArticleResearchpeer-review