Research Output

Filter
Article
2020

A novel approach for non‐invasive lung imaging and targeting lung immune cells

Chakraborty, A., Royce, S. G., Selomulya, C. & Plebanski, M., 1 Mar 2020, In : International Journal of Molecular Sciences. 21, 5, 18 p., 1613.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
1 Citation (Scopus)

Decreased Placental FPR2 in Early Pregnancies That Later Developed Small-For-Gestation Age: A Potential Role of FPR2 in the Regulation of Epithelial-Mesenchymal Transition

Murthi, P., Rajaraman, G., Erwich, J. J. H. M. & Dimitriadis, E., 10 Apr 2020, In : Cells. 9, 4, 19 p., 921.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File

Detailed In Vitro Pharmacological Characterization of Clinically Tested Negative Allosteric Modulators of the Metabotropic Glutamate Receptor 5

Arsova, A., Møller, T. C., Vedel, L., Hansen, J. L., Foster, S. R., Gregory, K. J. & Bräuner-Osborne, H., 1 Jul 2020, In : Molecular Pharmacology. 98, 1, p. 49-60 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File

Empagliflozin modulates renal sympathetic and heart rate baroreflexes in a rabbit model of diabetes

Gueguen, C., Burke, S. L., Barzel, B., Eikelis, N., Watson, A. M. D., Jha, J. C., Jackson, K. L., Sata, Y., Lim, K., Lambert, G. W., Jandeleit-Dahm, K. A. M., Cooper, M. E., Thomas, M. C. & Head, G. A., Jul 2020, In : Diabetologia. 63, 7, p. 1424–1434 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Granzyme A in Chikungunya and Other Arboviral Infections

Schanoski, A. S., Le, T. T., Kaiserman, D., Rowe, C., Prow, N. A., Barboza, D. D., Santos, C. A., Zanotto, P. M. A., Magalhães, K. G., Aurelio, L., Muller, D., Young, P., Zhao, P., Bird, P. I. & Suhrbier, A., 14 Jan 2020, In : Frontiers in Immunology. 10, 14 p., 3083.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
2 Citations (Scopus)

Hydroxychloroquine mitigates the production of 8-isoprostane and improves vascular dysfunction: Implications for treating preeclampsia

Abd Rahman, R., Murthi, P., Singh, H., Gurungsinghe, S., Leaw, B., Mockler, J. C., Lim, R. & Wallace, E. M., Apr 2020, In : International Journal of Molecular Sciences. 21, 7, 14 p., 2504.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File

Identification of monellin as the first naturally derived proteinaceous allosteric agonist of metabotropic glutamate receptor 5

Chen, A. N. Y., Hellyer, S. D., Trinh, P. N. H., Leach, K. & Gregory, K. J., Jun 2020, In : Basic & Clinical Pharmacology & Toxicology. 126, S6, p. 104-115 12 p.

Research output: Contribution to journalArticleResearchpeer-review

1 Citation (Scopus)

Imbalance of the renin-angiotensin system may contribute to inflammation and fibrosis in IBD: a novel therapeutic target?

Garg, M., Royce, S. G., Tikellis, C., Shallue, C., Batu, D., Velkoska, E., Burrell, L. M., Patel, S. K., Beswick, L., Jackson, A., Britto, K., Lukies, M., Sluka, P., Wardan, H., Hirokawa, Y., Tan, C. W., Faux, M., Burgess, A. W., Hosking, P., Monagle, S. & 3 others, Thomas, M., Gibson, P. R. & Lubel, J., 1 May 2020, In : Gut. 69, 5, p. 841-851 11 p.

Research output: Contribution to journalArticleResearchpeer-review

16 Citations (Scopus)

Isolation and pharmacological characterization of α-Elapitoxin-Na1a, a novel short-chain postsynaptic neurotoxin from the venom of the Chinese Cobra (Naja atra)

Liang, Q., Huynh, T. M., Isbister, G. K. & Hodgson, W. C., 28 May 2020, (Accepted/In press) In : Biochemical Pharmacology. 8 p., 114059.

Research output: Contribution to journalArticleResearchpeer-review

Neural suppression of miRNA-181a in the kidney elevates renin expression and exacerbates hypertension in Schlager mice

Jackson, K. L., Gueguen, C., Lim, K., Eikelis, N., Stevenson, E. R., Charchar, F. J., Lambert, G. W., Burke, S. L., Paterson, M. R., Marques, F. Z. & Head, G. A., 19 May 2020, (Accepted/In press) In : Hypertension Research. 13 p.

Research output: Contribution to journalArticleResearchpeer-review

1 Citation (Scopus)

Nitric Oxide Resistance, Induced in the Myocardium by Diabetes, Is Circumvented by the Nitric Oxide Redox Sibling, Nitroxyl

Qin, C. X., Anthonisz, J., Leo, C. H., Kahlberg, N., Velagic, A., Li, M., Jap, E., Woodman, O. L., Parry, L. J., Horowitz, J. D., Kemp-Harper, B. K. & Ritchie, R. H., 1 Jan 2020, In : Antioxidants and Redox Signaling. 32, 1, p. 60-78 19 p.

Research output: Contribution to journalArticleResearchpeer-review

Renal functional effects of the highly selective AT2R agonist, β-Pro7 Ang III, in normotensive rats

Hilliard Krause, L. M., Kemp, B. A., Tan, A. S. J., Jones, E. S., Del Borgo, M. P., Aguilar, M. I., Denton, K. M., Carey, R. M. & Widdop, R. E., 17 Apr 2020, In : Clinical Science. 134, 7, p. 871-884 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File

The anti-fibrotic actions of relaxin are mediated through AT2R-associated protein phosphatases via RXFP1-AT2R functional crosstalk in human cardiac myofibroblasts

Wang, C., Pinar, A. A., Widdop, R. E., Hossain, M. A., Bathgate, R. A. D., Denton, K. M., Kemp-Harper, B. K. & Samuel, C. S., 16 Apr 2020, (Accepted/In press) In : The FASEB Journal. 17 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File

The Effects of Early-Onset Pre-Eclampsia on Placental Creatine Metabolism in the Third Trimester

Ellery, S. J., Murthi, P., Gatta, P. A. D., May, A. K., Davies-Tuck, M. L., Kowalski, G. M., Callahan, D. L., Bruce, C. R., Wallace, E. M., Walker, D. W., Dickinson, H. & Snow, R. J., 26 Jan 2020, In : International Journal of Molecular Sciences. 21, 3, 14 p., 806.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File

Transition of Nano-Architectures Through Self-Assembly of Lipidated β3-Tripeptide Foldamers

Habila, N., Kulkarni, K., Lee, T-H., Al-Garawi, Z. S., Serpell, L. C., Aguilar, M-I. & Del Borgo, M. P., 31 Mar 2020, In : Frontiers in Chemistry. 8, 11 p., 217.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
2019

6-Phenylpyrimidin-4-ones as Positive Allosteric Modulators at the M1 mAChR: The Determinants of Allosteric Activity

Jorg, M. T., van der Westhuizen, E. T., Khajehali, E., Burger, W. A. C., White, J., Choy, K. H. C., Tobin, A. B., Sexton, P. M., Valant, C., Capuano, B., Christopoulos, A. & Scammells, P. J., 20 Mar 2019, In : ACS Chemical Neuroscience. 10, 3, p. 1099-1114 16 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File

A ligand-induced structural change in fatty acid-binding protein 1 is associated with potentiation of peroxisome proliferator-activated receptor α agonists

Patil, R., Mohanty, B., Liu, B., Chandrashekaran, I. R., Headey, S. J., Williams, M. L., Clements, C. S., Ilyichova, O., Doak, B. C., Genissel, P., Weaver, R., Vuillard, L., Halls, M. L., Porter, C. J. H. & Scanlon, M. J., 8 Mar 2019, In : The Journal of Biological Chemistry. 294, 10, p. 3720-3734 15 p.

Research output: Contribution to journalArticleResearchpeer-review

2 Citations (Scopus)

An in vivo examination of the differences between rapid cardiovascular collapse and prolonged hypotension induced by snake venom

Kakumanu, R., Kemp-Harper, B. K., Silva, A., Kuruppu, S., Isbister, G. K. & Hodgson, W. C., 27 Dec 2019, In : Scientific Reports. 9, 1, 9 p., 20231.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
2 Citations (Scopus)

A Novel Epigenetic Drug-Eluting Balloon Angioplasty Device: Evaluation in a Large Animal Model of Neointimal Hyperplasia

Liu, H., Byrne, M., Perlmutter, P., Walker, A., Sama, G. R., Subbiah, J., Ozcelik, B., Widdop, R. E., Gaspari, T. A., Byron, K., Chen, Y-C., Kaye, D. M. & Dear, A. E., 30 Dec 2019, In : Cardiovascular Drugs and Therapy. 33, 6, p. 687-692 6 p.

Research output: Contribution to journalArticleResearchpeer-review

1 Citation (Scopus)

A Series of Analogues to the AT 2 R Prototype Antagonist C38 Allow Fine Tuning of the Previously Reported Antagonist Binding Mode

Isaksson, R., Lindman, J., Wannberg, J., Sallander, J., Backlund, M., Baraldi, D., Widdop, R., Hallberg, M., Åqvist, J., Gutierrez de Teran, H., Gising, J. & Larhed, M., 1 Jan 2019, In : ChemistryOpen. 8, 1, p. 114-125 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
3 Citations (Scopus)

AT1R-AT2R-RXFP1 functional crosstalk in myofibroblasts: Impact on the therapeutic targeting of renal and cardiac fibrosis

Chow, B. S. M., Kocan, M., Shen, M., Wang, Y., Han, L., Chew, J. Y., Wang, C., Bosnyak, S., Mirabito-Colafella, K. M., Barsha, G., Wigg, B., Johnstone, E. K. M., Hossain, M. A., Pfleger, K. D. G., Denton, K. M., Widdop, R. E., Summers, R. J., Bathgate, R. A. D., Hewitson, T. D. & Samuel, C. S., 1 Jan 2019, In : Journal of the American Society of Nephrology. 30, 11, p. 2191-2207 17 p.

Research output: Contribution to journalArticleResearchpeer-review

3 Citations (Scopus)

A Thieno[2,3-d]pyrimidine Scaffold is a Novel Negative Allosteric Modulator of the Dopamine D2 Receptor

Fyfe, T. J., Zarzycka, B., Lim, H. D., Kellam, B., Mistry, S. N., Katrich, V., Scammells, P. J., Lane, J. R. & Capuano, B., 1 Oct 2019, In : Journal of Medicinal Chemistry. 62, 1, p. 174-206 33 p.

Research output: Contribution to journalArticleResearchpeer-review

3 Citations (Scopus)

Atypical cannabinoid ligands O-1602 and O-1918 administered chronically in diet-induced obesity

Simcocks, A. C., Jenkin, K. A., O’Keefe, L., Samuel, C. S., Mathai, M. L., McAinch, A. J. & Hryciw, D. H., Mar 2019, In : Endocrine Connections. 8, 3, p. 203-216 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
2 Citations (Scopus)

BRL37344 stimulates GLUT4 translocation and glucose uptake in skeletal muscle via β 2 -adrenoceptors without causing classical receptor desensitization

Mukaida, S., Sato, M., Öberg, A. I., Dehvari, N., Olsen, J. M., Kocan, M., Halls, M. L., Merlin, J., Sandström, A. L., Csikasz, R. I., Evans, B. A., Summers, R. J., Hutchinson, D. S. & Bengtsson, T., 1 May 2019, In : American Journal of Physiology - Regulatory Integrative and Comparative Physiology. 316, 5, p. R666-R677 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
2 Citations (Scopus)

Cardioprotective actions of the annexin-A1 N-terminal peptide, AC2-26, against myocardial infarction

Qin, C. X., Rosli, S., Deo, M., Cao, N., Walsh, J., Tate, M., Alexander, A. E., Donner, D., Horlock, D., Li, R., Kiriazis, H., Lee, M. K. S., Bourke, J. E., Yang, Y., Murphy, A. J., Du, X-J., Gao, X. M. & Ritchie, R. H., 3 Apr 2019, In : Frontiers in Pharmacology. 10, 16 p., 269.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
7 Citations (Scopus)

Chronic sympathetic driven hypertension promotes atherosclerosis by enhancing hematopoiesis

Al-Sharea, A., Lee, M. K. S., Whillas, A., Michell, D. L., Shihata, W. A., Nicholls, A. J., Cooney, O. D., Kraakman, M. J., Veiga, C. B., Jefferis, A. M., Jackson, K., Nagareddy, P. R., Lambert, G., Wong, C. H. Y., Andrews, K. L., Head, G. A., Chin-Dusting, J. & Murphy, A. J., 28 Feb 2019, In : Haematologica: the hematology journal. 104, 3, p. 456-467 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
9 Citations (Scopus)

D. Russelii venom mediates vasodilatation of resistance like arteries via activation of k v and k ca channels

Kakumanu, R., Kuruppu, S., Rash, L. D., Isbister, G. K., Hodgson, W. C. & Kemp-Harper, B. K., 1 Apr 2019, In : Toxins. 11, 4, 10 p., 197.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
1 Citation (Scopus)

Distinct Redox Signalling following Macrophage Activation Influences Profibrotic Activity

Lewis, C. V., Vinh, A., Diep, H., Samuel, C. S., Drummond, G. R. & Kemp-Harper, B. K., 11 Nov 2019, In : Journal of Immunology Research. 2019, 15 p., 1278301.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
1 Citation (Scopus)

Drug-receptor kinetics and sigma-1 receptor affinity differentiate clinically evaluated histamine H3 receptor antagonists

Riddy, D. M., Cook, A. E., Shackleford, D. M., Pierce, T. L., Mocaer, E., Mannoury la Cour, C., Sors, A., Charman, W. N., Summers, R. J., Sexton, P. M., Christopoulos, A. & Langmead, C. J., 1 Jan 2019, In : Neuropharmacology. 144, p. 244-255 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
6 Citations (Scopus)

Dysregulation of the placental renin–angiotensin system in human fetal growth restriction

Delforce, S. J., Lumbers, E. R., Ellery, S. J., Murthi, P. & Pringle, K. G., Sep 2019, In : Reproduction. 158, 3, p. 237-245 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Effects of high- and low-dose aspirin on adaptive immunity and hypertension in the stroke-prone spontaneously hypertensive rat

Khan, S. I., Shihata, W. A., Andrews, K. L., Lee, M. K. S., Moore, X-L., Jefferis, A-M., Vinh, A., Gaspari, T., Dragoljevic, D., Jennings, G. L., Murphy, A. J. & Chin-Dusting, J. P. F., 1 Jan 2019, In : The FASEB Journal. 33, 1, p. 1510-1521 12 p.

Research output: Contribution to journalArticleResearchpeer-review

4 Citations (Scopus)

Expression and activity of the calcitonin receptor family in a sample of primary human high-grade gliomas

Ostrovskaya, A., Hick, C., Hutchinson, D. S., Stringer, B. W., Wookey, P. J., Wootten, D., Sexton, P. M. & Furness, S. G. B., 18 Feb 2019, In : BMC Cancer. 19, 1, 12 p., 157.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
1 Citation (Scopus)

Glycine microparticles loaded with functionalized nanoparticles for pulmonary delivery

Chakraborty, A., Royce, S. G., Plebanski, M. & Selomulya, C., 30 Oct 2019, In : International Journal of Pharmaceutics. 570, 9 p., 118654.

Research output: Contribution to journalArticleResearchpeer-review

1 Citation (Scopus)

GRK mediates µ-opioid receptor plasma membrane reorganization

Gondin, A. B., Halls, M. L., Canals, M. & Briddon, S. J., 1 May 2019, In : Frontiers in Molecular Neuroscience. 12, 14 p., 104.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
3 Citations (Scopus)

Human amnion epithelial cells and their soluble factors reduce liver fibrosis in murine non-alcoholic steatohepatitis

Kuk, N., Hodge, A., Sun, Y., Correia, J., Alhomrani, M., Samuel, C., Moore, G., Lim, R. & Sievert, W., Aug 2019, In : Journal of Gastroenterology and Hepatology. 34, 8, p. 1441-1449 9 p.

Research output: Contribution to journalArticleResearchpeer-review

3 Citations (Scopus)

IL-37 increases in patients after ischemic stroke and protects from inflammatory brain injury, motor impairment and lung infection in mice

Zhang, S. R., Nold, M. F., Tang, S. C., Bui, C. B., Nold, C. A., Arumugam, T. V., Drummond, G. R., Sobey, C. G. & Kim, H. A., 1 Dec 2019, In : Scientific Reports. 9, 1, 12 p., 6922.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
6 Citations (Scopus)

Interleukin-1 receptor antagonist protects newborn mice against pulmonary hypertension

Bui, C. B., Kolodziej, M., Lamanna, E., Elgass, K., Sehgal, A., Rudloff, I., Schwenke, D. O., Tsuchimochi, H., Kroon, M. A. G. M., Cho, S. X., Maksimenko, A., Cholewa, M., Berger, P. J., Young, M. J., Bourke, J. E., Pearson, J. T., Nold, M. F. & Nold-Petry, C. A., 11 Jul 2019, In : Frontiers in Immunology. 10, JULY, 15 p., 1480.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
2 Citations (Scopus)
1 Citation (Scopus)

Kinetic and system bias as drivers of metabotropic glutamate receptor 5 allosteric modulator pharmacology

Sengmany, K., Hellyer, S. D., Albold, S., Wang, T., Conn, P. J., May, L. T., Christopoulos, A., Leach, K. & Gregory, K. J., 1 May 2019, In : Neuropharmacology. 149, p. 83-96 14 p.

Research output: Contribution to journalArticleResearchpeer-review

5 Citations (Scopus)

Molecular Basis of Action of a Small-Molecule Positive Allosteric Modulator Agonist at the Type 1 Cholecystokinin Holoreceptor

Desai, A. J., Mechin, I., Nagarajan, K., Valant, C., Wootten, D., Lam, P. C. H., Orry, A., Abagyan, R., Nair, A., Sexton, P. M., Christopoulos, A. & Miller, L. J., 1 Mar 2019, In : Molecular Pharmacology. 95, 3, p. 245-259 15 p.

Research output: Contribution to journalArticleResearchpeer-review

NOx in exhaled breath condensate is related to allergic sensitization in young and middle-aged adults

Aldakheel, F. M., Bourke, J. E., Thomas, P. S., Matheson, M. C., Abramson, M. J., Hamilton, G. S., Lodge, C. J., Thompson, B. R., Haydn Walters, E., Allen, K. J., Erbas, B., Perret, J. L., Dharmage, S. C. & Lowe, A. J., Feb 2019, In : Clinical & Experimental Allergy. 49, 2, p. 171-179 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
2 Citations (Scopus)

Pharmacological inhibition of the NLRP3 inflammasome reduces blood pressure, renal damage, and dysfunction in salt-sensitive hypertension

Krishnan, S. M., Ling, Y. H., Huuskes, B. M., Ferens, D. M., Saini, N., Chan, C. T., Diep, H., Kett, M. M., Samuel, C. S., Kemp-Harper, B. K., Robertson, A. A. B., Cooper, M. A., Peter, K., Latz, E., Mansell, A. S., Sobey, C. G., Drummond, G. R. & Vinh, A., 15 Mar 2019, In : Cardiovascular Research. 115, 4, p. 776-787 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
29 Citations (Scopus)

Profiling histone modifications in the normal mouse kidney and after unilateral ureteric obstruction

Hewitson, T. D., Holt, S. G., Samuel, C. S., Wigg, B. & Smith, E. R., 1 Sep 2019, In : American Journal of Physiology-Renal Physiology. 317, 3, p. F606-F615 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File

Serelaxin enhances the therapeutic effects of human amnion epithelial cell-derived exosomes in experimental models of lung disease

Royce, S. G., Patel, K. P., Mao, W., Zhu, D., Lim, R. & Samuel, C. S., Jul 2019, In : British Journal of Pharmacology. 176, 13, p. 2195-2208 14 p.

Research output: Contribution to journalArticleResearchpeer-review

2 Citations (Scopus)

Serelaxin inhibits the profibrotic TGF-β1/IL-1β axis by targeting TLR-4 and the NLRP3 inflammasome in cardiac myofibroblasts

Tapia Caceres, F., Gaspari, T. A., Samuel, C. S. & Pinar, A. A., 1 Dec 2019, In : The FASEB Journal. 33, 12, p. 14717-14733 17 p.

Research output: Contribution to journalArticleResearchpeer-review

Social behaviour is altered in the insulin-regulated aminopeptidase knockout mouse

Burns, P., Bowditch, J., McFadyen, J., Loiacono, R., Albiston, A. L., Pham, V. & Chai, S. Y., 30 Dec 2019, In : Behavioural Brain Research. 376, 7 p., 112150.

Research output: Contribution to journalArticleResearchpeer-review

Solenodon genome reveals convergent evolution of venom in eulipotyphlan mammals

Casewell, N. R., Petras, D., Card, D. C., Suranse, V., Mychajliw, A. M., Richards, D., Koludarov, I., Albulescu, L. O., Slagboom, J., Hempel, B. F., Ngum, N. M., Kennerley, R. J., Brocca, J. L., Whiteley, G., Harrison, R. A., Bolton, F. M. S., Debono, J., Vonk, F. J., Alföldi, J., Johnson, J. & 13 others, Karlsson, E. K., Lindblad-Toh, K., Mellor, I. R., Süssmuth, R. D., Fry, B. G., Kuruppu, S., Hodgson, W. C., Kool, J., Castoe, T. A., Barnes, I., Sunagar, K., Undheim, E. A. B. & Turvey, S. T., 17 Dec 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 116, 51, p. 25745-25755 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
2 Citations (Scopus)

Subtle modifications to a thieno[2,3-d]pyrimidine scaffold yield negative allosteric modulators and agonists of the dopamine D 2 receptor

Fyfe, T. J., Kellam, B., Mistry, S. N., Scammells, P. J., Lane, J. R. & Capuano, B., 15 Apr 2019, In : European Journal of Medicinal Chemistry. 168, p. 474-490 17 p.

Research output: Contribution to journalArticleResearchpeer-review

1 Citation (Scopus)

The efficacy of pirfenidone in a sheep model of pulmonary fibrosis

Dewage, S. N. V., Organ, L., Koumoundouros, E., Derseh, H. B., Perera, K. U. E., Samuel, C. S., Stent, A. W. & Snibson, K. J., 26 Nov 2019, In : Experimental Lung Research. 45, 9-10, p. 310-322 13 p.

Research output: Contribution to journalArticleResearchpeer-review