Research Output

2014

Biased agonism at G protein-coupled receptors: The promise and the challenges - A medicinal chemistry perspective

Shonberg, J., Lopez Munoz, L., Scammells, P. J., Christopoulos, A., Capuano, B. & Lane, J. R. D., 2014, In : Medicinal Research Reviews. 34, 6, p. 1286 - 1330 45 p.

Research output: Contribution to journalArticleResearchpeer-review

76 Citations (Scopus)

Brain immune cell composition and functional outcome after cerebral ischemia: comparison of two mouse strains

Kim, H. A., Whittle, S., Lee, S. S., Chu, H., Zhang, S., Wei, Z., Arumugam, T., Vinh, A., Drummond, G. R. & Sobey, C. G., 2014, In : Frontiers in Cellular Neuroscience. 8, 365, 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Cathepsin S causes inflammatory pain via biased agonism of PAR2 and TRPV4

Zhao, P., Lieu, T. M., Barlow, N., Metcalf, M., Veldhuis, N. A., Jensen, D. D., Kocan, M., Sostegni, S., Haerteis, S., Baraznenok, V. A., Henderson, I., Lindstrom, E., Guerrero-Alba, R., Valdez-Morales, E., Liedtke, W., McIntyre, P., Vanner, S., Korbmacher, C. & Bunnett, N. W., 2014, In : The Journal of Biological Chemistry. 289, 39, p. 27215 - 27234 20 p.

Research output: Contribution to journalArticleResearchpeer-review

84 Citations (Scopus)

Characterization of a novel model incorporating airway epithelial damage and related fibrosis to the pathogenesis of asthma

Royce, S. G., Patel, K. P. & Samuel, C. S., 2014, In : Laboratory Investigation. 94, 12, p. 1326 - 1339 14 p.

Research output: Contribution to journalArticleResearchpeer-review

12 Citations (Scopus)

Characterization of the novel positive allosteric modulator, LY2119620, at the muscarinic M(2) and M(4) receptors

Croy, C. H., Schober, D. A., Xiao, H., Quets, A., Christopoulos, A. & Felder, C. C., 2014, In : Molecular Pharmacology. 86, 1, p. 106 - 115 10 p.

Research output: Contribution to journalArticleResearchpeer-review

27 Citations (Scopus)

Chironex fleckeri (box jellyfish) venom proteins: expansion of a cnidarian toxin family that elicits variable cytolytic and cardiovascular effects

Brinkman, D. L., Konstantakopoulos, N., McInerney, B., Mulvenna, J., Seymour, J. E., Isbister, G. K. & Hodgson, W. C., 2014, In : The Journal of Biological Chemistry. 289, 8, p. 4798 - 4812 15 p.

Research output: Contribution to journalArticleResearchpeer-review

35 Citations (Scopus)

Chronic aldosterone administration causes Nox2-mediated increases in reactive oxygen species production and endothelial dysfunction in the cerebral circulation

Chrissobolis, S., Drummond, G. R., Faraci, F. M. & Sobey, C. G., 2014, In : Journal of Hypertension. 32, 9, p. 1815 - 1821 7 p.

Research output: Contribution to journalArticleResearchpeer-review

19 Citations (Scopus)

Comparative studies of the venom of a new Taipan species, Oxyuranus temporalis, with other members of its genus

Barber, C. M., Madaras, F., Turnbull, R. K., Morley, T., Dunstan, N., Allen, L., Kuchel, T., Mirtschin, P. & Hodgson, W. C., 2014, In : Toxins. 6, 7, p. 1979 - 1995 17 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
3 Citations (Scopus)

Correction to Septic shock: Desperately seeking treatment [Clinical Science, 126 (2014), 31-39]

Huet, O. & Chin-Dusting, J. P. F., Mar 2014, In : Clinical Science. 126, 6, p. 459 1 p.

Research output: Contribution to journalComment / DebateOtherpeer-review

DC isoketal-modified proteins activate T cells and promote hypertension

Kirabo, A., Fontana, V., de Faria, A. P. C., Loperena, R., Galindo, C. L., Wu, J., Bikineyeva, A. T., Dikalov, S., Xiao, L., Chen, W., Saleh, M. A., Trott, D. W., Itani, H. A., Vinh, A., Amarnath, V., Amarnath, K., Guzik, T. J., Bernstein, K. E., Shen, X. G. Z., Shyr, Y. & 9 others, Chen, S-C., Mernaugh, R. L., Laffer, C. L., Elijovich, F., Davies, S. S., Moreno, H., Madhur, M. S., Roberts II, L. J. & Harrison, D. G., 2014, In : Journal of Clinical Investigation. 124, 10, p. 4642 - 4656 15 p.

Research output: Contribution to journalArticleResearchpeer-review

203 Citations (Scopus)

Development of a photoactivatable allosteric ligand for the M1 muscarinic acetylcholine receptor

Davie, B. J., Sexton, P., Capuano, B., Christopoulos, A. & Scammells, P. J., 2014, In : ACS Chemical Neuroscience. 5, 10, p. 902 - 907 6 p.

Research output: Contribution to journalArticleResearchpeer-review

8 Citations (Scopus)

Development of a radioligand, [(3)H]LY2119620, to probe the human M(2) and M(4) muscarinic receptor allosteric binding sites

Schober, D. A., Croy, C. H., Xiao, H., Christopoulos, A. & Felder, C. C., 2014, In : Molecular Pharmacology. 86, 1, p. 116 - 123 8 p.

Research output: Contribution to journalArticleResearchpeer-review

18 Citations (Scopus)

Differential phenotypes of tissue-infiltrating T cells during angiotensin II-induced hypertension in mice

Wei, Z., Spizzo, I., Diep, H., Drummond, G. R., Widdop, R. E. & Vinh, A., 2014, In : PLoS ONE. 9, 12, 21 p., e114895.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
25 Citations (Scopus)

Direct angiotensin AT2 receptor stimulation using a novel AT2 receptor agonist, compound 21, evokes neuroprotection in conscious hypertensive rats

McCarthy, C. A., Vinh, A., Miller, A. A., Hallberg, A., Alterman, M., Callaway, J. K. & Widdop, R. E., 2014, In : PLoS ONE. 9, 4 (Art. No: e95762), p. 1 - 10 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
47 Citations (Scopus)

Electronic sculpting of ligand-GPCR subtype selectivity: the case of angiotensin II

Magnani, F., Pappas, C. G., Crook, T., Magafa, V., Cordopatis, P. A., Ishiguro, S., Ohta, N., Selent, J., Bosnyak, S., Jones, E. S., Gerothanassis, I. P., Tamura, M., Widdop, R. E. & Tzakos, A. G., 2014, In : ACS Chemical Biology. 9, 7, p. 1420 - 1425 6 p.

Research output: Contribution to journalArticleResearchpeer-review

17 Citations (Scopus)

Endothelial cell mineralocorticoid receptors regulate deoxycorticosterone/salt-mediated cardiac remodeling and vascular reactivity but not blood pressure

Rickard, A., Morgan, J., Chrissobolis, S., Miller, A. A., Sobey, C. G. & Young, M. J., 2014, In : Hypertension. 63, 5, p. 1033 - 1040 8 p.

Research output: Contribution to journalArticleResearchpeer-review

69 Citations (Scopus)

Endothelial NADPH oxidases: which NOX to target in vascular disease?

Drummond, G. R. & Sobey, C. G., 2014, In : Trends in Endocrinology & Metabolism. 25, 9, p. 452 - 463 12 p.

Research output: Contribution to journalArticleResearchpeer-review

156 Citations (Scopus)

Endothelin-converting enzyme 1 and beta-arrestins exert spatiotemporal control of substance P-induced inflammatory signals

Jensen, D. D., Halls, M. L., Murphy, J. E., Canals, M., Cattaruzza, F., Poole, D. P., Lieu, T. M., Koon, H-W., Pothoulakis, C. & Bunnett, N. W., 2014, In : The Journal of Biological Chemistry. 289, 29, p. 20283 - 20294 12 p.

Research output: Contribution to journalArticleResearchpeer-review

13 Citations (Scopus)

Energy metabolism in BPH/2J genetically hypertensive mice

Jackson, K. L., Nguyen-Huu, T-P., Davern, P. J. & Head, G. A., 2014, In : Hypertension Research. 37, 5, p. 413 - 421 9 p.

Research output: Contribution to journalArticleResearchpeer-review

3 Citations (Scopus)

Engendering biased signalling from the calcium-sensing receptor for the pharmacotherapy of diverse disorders

Leach, K., Sexton, P., Christopoulos, A. & Conigrave, A., 2014, In : British Journal of Pharmacology. 171, 5, p. 1142 - 1155 14 p.

Research output: Contribution to journalArticleResearchpeer-review

28 Citations (Scopus)

Evidence that collaboration between HIF-1a and Notch-1 promotes neuronal cell death in ischemic stroke

Cheng, Y-L., Park, J-S., Manzanero, S., Choi, Y., Baik, S-H., Okun, E., Gelderblom, M., Fann, D. Y-W., Magnus, T., Launikonis, B. S., Mattson, M. P., Sobey, C. G., Jo, D-G. & Arumugam, T., 2014, In : Neurobiology of Disease. 62, p. 286 - 295 10 p.

Research output: Contribution to journalArticleResearchpeer-review

43 Citations (Scopus)

Evidence that neuronal Notch-1 promotes JNK/c-Jun activation and cell death following ischemic stress

Cheng, Y-L., Choi, Y., Seow, W. L., Manzanero, S., Sobey, C. G., Jo, D-G. & Arumugam, T. V., 2014, In : Brain Research. 1586, p. 193 - 202 10 p.

Research output: Contribution to journalArticleResearchpeer-review

22 Citations (Scopus)

Exposure to a high-fat diet during development alters leptin and ghrelin sensitivity and elevates renal sympathetic nerve activity and arterial pressure in rabbits

Prior, L. J., Davern, P. J., Burke, S. L., Lim, K., Armitage, J. A. & Head, G. A., 2014, In : Hypertension. 63, 2, p. 338 - 345 8 p.

Research output: Contribution to journalArticleResearchpeer-review

49 Citations (Scopus)

Feeding-dependent activation of enteric cells and sensory neurons by lymphatic fluid: Evidence for a neurolymphocrine system

Poole, D. P., Lee, M., Tso, P., Bunnett, N. W., Yo, S. J., Lieu, T. M., Shiu, A., Wang, J-C., Nomura, D. & Aponte, G. W., 2014, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 306, 8, p. G686 - G698 13 p.

Research output: Contribution to journalArticleResearchpeer-review

5 Citations (Scopus)

Functional and structural perspectives on allosteric modulation of GPCRs

Langmead, C. J. & Christopoulos, A., 2014, In : Current Opinion in Cell Biology. 27, 1, p. 94 - 101 8 p.

Research output: Contribution to journalArticleResearchpeer-review

23 Citations (Scopus)

GABAA receptor dysfunction contributes to high blood pressure and exaggerated response to stress in Schlager genetically hypertensive mice

Davern, P. J., Chowdhury, S., Jackson, K. L., Nguyen-Huu, T-P. & Head, G. A., 2014, In : Journal of Hypertension. 32, 2, p. 352 - 362 11 p.

Research output: Contribution to journalArticleResearchpeer-review

10 Citations (Scopus)

GPBA: A GPCR for bile acids and an emerging therapeutic target for disorders of digestion and sensation

Lieu, T. M., Jayaweera, G. & Bunnett, N. W., 2014, In : British Journal of Pharmacology. 171, 5, p. 1156 - 1166 11 p.

Research output: Contribution to journalArticleResearchpeer-review

29 Citations (Scopus)

Human mesenchymal stem cells alter macrophage phenotype and promote regeneration via homing to the kidney following ischemia-reperfusion injury

Wise, A. F., Williams, T. M., Kiewiet, M. B. G., Payne, N. L., Siatskas, C., Samuel, C. S. & Ricardo, S. D., 2014, In : American Journal of Physiology-Renal Physiology. 306, 10, p. 1222 - 1235 14 p.

Research output: Contribution to journalArticleResearchpeer-review

71 Citations (Scopus)

Hydrogen sulfide protects endothelial nitric oxide function under conditions of acute oxidative stress in vitro

Al-Magableh, M. R., Harper, B. K., Ng, H. H., Miller, A. A. & Hart, J., 2014, In : Naunyn-Schmiedeberg's Archives of Pharmacology. 387, 1, p. 67 - 74 8 p.

Research output: Contribution to journalArticleResearchpeer-review

37 Citations (Scopus)

Hypotensive and vascular relaxant effects of phospholipase A2 toxins from Papuan taipan (Oxyuranus scutellatus) venom

Chaisakul, J., Isbister, G. K., Tare, M., Parkington, H. C. & Hodgson, W. C., 2014, In : European Journal of Pharmacology. 723, 1, p. 227 - 233 7 p.

Research output: Contribution to journalArticleResearchpeer-review

12 Citations (Scopus)

Identification of genes with altered expression in male and female Schlager hypertensive mice

Chiu, C., Jackson, K. E., Hearn, N. L., Steiner, N., Head, G. A. & Lind, J. M., 2014, In : BMC Medical Genetics. 15, 1 9Art. No.: 101), p. 1 - 6 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
5 Citations (Scopus)

Identification of overlapping but differential binding sites for the high-affinity CXCR3 antagonists NBI-74330 and VUF11211

Scholten, D. J., Roumen, L., Wijtmans, M., Verkade-Vreeker, M. C. A., Custers, H., Lai, M., de Hooge, D., Canals, M., de Esch, I. J. P., Smit, M. J., de Graaf, C. & Leurs, R., Jan 2014, In : Molecular Pharmacology. 85, 1, p. 116-126 11 p.

Research output: Contribution to journalArticleResearchpeer-review

19 Citations (Scopus)

IL-1beta and IL-18: inflammatory markers or mediators of hypertension?

Murali Krishnan, S., Sobey, C. G., Latz, E., Mansell, A. S. & Drummond, G. R., 2014, In : British Journal of Pharmacology. 171, 24, p. 5589 - 5602 14 p.

Research output: Contribution to journalArticleResearchpeer-review

72 Citations (Scopus)

Immune cell infiltration in malignant middle cerebral artery infarction: comparison with transient cerebral ischemia

Chu, H. X., Huynh, K., Lee, S. S., Moore, J. P., Chan, C. T. L., Vinh, A., Gelderblom, M., Arumugam, T., Broughton, B. R. S., Drummond, G. R. & Sobey, C. G., 2014, In : Journal of Cerebral Blood Flow and Metabolism. 34, 3, p. 450 - 459 10 p.

Research output: Contribution to journalArticleResearchpeer-review

87 Citations (Scopus)

Immune mechanisms in vascular disease and stroke

Toh, B-H., Bobik, A., Kyaw, T. S., Drummond, G. R., Sobey, C. G. & Guzik, T. J., 2014, In : BioMed Research International. 2014, p. e730691 - e730691 3 p.

Research output: Contribution to journalLetterOther

Improving type 2 diabetes through a distinct adrenergic signaling pathway involving mTORC2 that mediates glucose uptake in skeletal muscle

Sato, M., Dehvari, N., Oberg, A., Dallner, O. S., Sandstrom, A. L., Olsen, J. M., Csikasz, R. I., Summers, R. J., Hutchinson, D. S. & Bengtsson, T., 2014, In : Diabetes. 63, 12, p. 4115 - 4129 15 p.

Research output: Contribution to journalArticleResearchpeer-review

50 Citations (Scopus)

Influenza A virus and TLR7 activation potentiate NOX2 oxidase-dependent ROS production in macrophages

To, E., Broughton, B. R. S., Hendricks, K. S., Vlahos, R. & Selemidis, S., 2014, In : Free Radical Research. 48, 8, p. 940 - 947 8 p.

Research output: Contribution to journalArticleResearchpeer-review

33 Citations (Scopus)

Inhibition of presynaptic neurotoxins in taipan venom by suramin

Kuruppu, D. M. S., Chaisakul, J., Smith, A. I. & Hodgson, W. C., 2014, In : Neurotoxicity Research. 25, 3, p. 305 - 310 6 p.

Research output: Contribution to journalArticleResearchpeer-review

2 Citations (Scopus)

International union of basic and clinical pharmacology. XC. Multisite pharmacology: Recommendations for the nomenclature of receptor allosterism and allosteric ligands

Christopoulos, A., Changeux, J-P., Catterall, W. A., Fabbro, D., Burris, T. P., Cidlowski, J. A., Olsen, R. W., Peters, J. A., Neubig, R., Pin, J. P., Sexton, P., Kenakin, T. P., Ehlert, F. J., Spedding, M. & Langmead, C. J., 2014, In : Pharmacological Reviews. 66, 4, p. 918 - 947 30 p.

Research output: Contribution to journalArticleResearchpeer-review

119 Citations (Scopus)

Intranasally administered serelaxin abrogates airway remodelling and attenuates airway hyperresponsiveness in allergic airways disease

Royce, S. G., Lim, C., Patel, K. P., Wang, B., Samuel, C. S. & Tang, M. L. K., 2014, In : Clinical & Experimental Allergy. 44, 11, p. 1399 - 1408 10 p.

Research output: Contribution to journalArticleResearchpeer-review

22 Citations (Scopus)

Intravenous immunoglobulin (IVIg) provides protection against endothelial cell dysfunction and death in ischemic stroke

Widiapradja, A., Santro, T., Basta, M., Sobey, C. G., Manzanero, S. & Arumugam, T., 2014, In : Experimental & Translational Stroke Medicine. 6, 1 (Art. No.: 7), p. 1 - 6 6 p.

Research output: Contribution to journalArticleResearchpeer-review

14 Citations (Scopus)

In-vitro neurotoxicity of two Malaysian krait species (Bungarus candidus and Bungarus fasciatus) venoms: neutralization by monovalent and polyvalent antivenoms from Thailand

Ahmad Rusmili, M. R., Tee, T. Y., Mustafa, M. R., Othman, I. & Hodgson, W. C., 2014, In : Toxins. 6, 3, p. 1036 - 1048 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
11 Citations (Scopus)

In vitro toxic effects of puff adder (Bitis arietans) venom, and their neutralization by antivenom

Fernandez, S., Hodgson, W. C., Chaisakul, J., Kornhauser, R. S., Konstantakopoulos, N., Smith, A. I. & Kuruppu, D. M. S., 2014, In : Toxins. 6, 5, p. 1586 - 1597 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
5 Citations (Scopus)

Isolation and characterization of alpha-elapitoxin-Bf1b, a postsynaptic neurotoxin from Malaysian Bungarus fasciatus venom

Ahmad Rusmili, M. R., Tee, T. Y., Mustafa, M. R., Othman, I. & Hodgson, W. C., 2014, In : Biochemical Pharmacology. 88, 2, p. 229 - 236 8 p.

Research output: Contribution to journalArticleResearchpeer-review

3 Citations (Scopus)

Isolation and characterization of a presynaptic neurotoxin, P-elapitoxin-Bf1a from Malaysian Bungarus fasciatus venom

Ahmad Rusmili, M. R., Tee, T. Y., Mustafa, M. R., Hodgson, W. C. & Othman, I., 2014, In : Biochemical Pharmacology. 91, 3, p. 409 - 416 8 p.

Research output: Contribution to journalArticleResearchpeer-review

5 Citations (Scopus)

Localisation and activation of the neurokinin 1 receptor in the enteric nervous system of the mouse distal colon

Pelayo, J-C., Veldhuis, N. A., Eriksson, E. M., Bunnett, N. W. & Poole, D. P., 2014, In : Cell and Tissue Research. 356, 2, p. 319 - 332 14 p.

Research output: Contribution to journalArticleResearchpeer-review

8 Citations (Scopus)

Localization of receptors for calcitonin-gene-related peptide to intraganglionic laminar endings of the mouse esophagus: Peripheral interaction between vagal and spinal afferents?

Horling, L., Bunnett, N. W., Messlinger, K., Neuhuber, W. L. & Raab, M., 2014, In : Histochemistry and Cell Biology. 141, 3, p. 321 - 335 15 p.

Research output: Contribution to journalArticleResearchpeer-review

4 Citations (Scopus)

Low-dose maternal alcohol consumption: effects in the hearts of offspring in early life and adulthood

Nguyen, V. B., Probyn, M. E., Campbell, F., Yin, K. V., Samuel, C. S., Zimanyi, M. A., Bertram, J. F., Black, M. J. & Moritz, K. M., 2014, In : Physiological Reports. 2, 7, p. 1 - 12 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
14 Citations (Scopus)

Major contribution of the medial amygdala to hypertension in BPH/2J genetically hypertensive mice

Jackson, K. L., Palma-Rigo, K., Nguyen-Huu, T-P., Davern, P. J. & Head, G. A., 2014, In : Hypertension. 63, 4, p. 811 - 818 8 p.

Research output: Contribution to journalArticleResearchpeer-review

13 Citations (Scopus)

Mechanistic insights into allosteric structure-function relationships at the M1 muscarinic acetylcholine receptor

Abdul Ridha, A., Lane, J. R. D., Mistry, S. N., Lopez Munoz, L., Sexton, P., Scammells, P. J., Christopoulos, A. & Canals, M., 2014, In : The Journal of Biological Chemistry. 289, 48, p. 33701 - 33711 11 p.

Research output: Contribution to journalArticleResearchpeer-review

34 Citations (Scopus)