Research Output 1986 2019

2014

GPBA: A GPCR for bile acids and an emerging therapeutic target for disorders of digestion and sensation

Lieu, T. M., Jayaweera, G. & Bunnett, N. W., 2014, In : British Journal of Pharmacology. 171, 5, p. 1156 - 1166 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Human mesenchymal stem cells alter macrophage phenotype and promote regeneration via homing to the kidney following ischemia-reperfusion injury

Wise, A. F., Williams, T. M., Kiewiet, M. B. G., Payne, N. L., Siatskas, C., Samuel, C. S. & Ricardo, S. D., 2014, In : American Journal of Physiology - Renal Physiology. 306, 10, p. 1222 - 1235 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Hydrogen sulfide protects endothelial nitric oxide function under conditions of acute oxidative stress in vitro

Al-Magableh, M. R., Harper, B. K., Ng, H. H., Miller, A. A. & Hart, J., 2014, In : Naunyn-Schmiedeberg's Archives of Pharmacology. 387, 1, p. 67 - 74 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Hypotensive and vascular relaxant effects of phospholipase A2 toxins from Papuan taipan (Oxyuranus scutellatus) venom

Chaisakul, J., Isbister, G. K., Tare, M., Parkington, H. C. & Hodgson, W. C., 2014, In : European Journal of Pharmacology. 723, 1, p. 227 - 233 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Identification of genes with altered expression in male and female Schlager hypertensive mice

Chiu, C., Jackson, K. E., Hearn, N. L., Steiner, N., Head, G. A. & Lind, J. M., 2014, In : BMC Medical Genetics. 15, 1 9Art. No.: 101), p. 1 - 6 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Identification of overlapping but differential binding sites for the high-affinity CXCR3 antagonists NBI-74330 and VUF11211

Scholten, D. J., Roumen, L., Wijtmans, M., Verkade-Vreeker, M. C. A., Custers, H., Lai, M., de Hooge, D., Canals, M., de Esch, I. J. P., Smit, M. J., de Graaf, C. & Leurs, R., Jan 2014, In : Molecular Pharmacology. 85, 1, p. 116-126 11 p.

Research output: Contribution to journalArticleResearchpeer-review

IL-1beta and IL-18: inflammatory markers or mediators of hypertension?

Murali Krishnan, S., Sobey, C. G., Latz, E., Mansell, A. S. & Drummond, G. R., 2014, In : British Journal of Pharmacology. 171, 24, p. 5589 - 5602 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Immune cell infiltration in malignant middle cerebral artery infarction: comparison with transient cerebral ischemia

Chu, H. X., Huynh, K., Lee, S. S., Moore, J. P., Chan, C. T. L., Vinh, A., Gelderblom, M., Arumugam, T., Broughton, B. R. S., Drummond, G. R. & Sobey, C. G., 2014, In : Journal of Cerebral Blood Flow and Metabolism. 34, 3, p. 450 - 459 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Immune mechanisms in vascular disease and stroke

Toh, B-H., Bobik, A., Kyaw, T. S., Drummond, G. R., Sobey, C. G. & Guzik, T. J., 2014, In : BioMed Research International. 2014, p. e730691 - e730691 3 p.

Research output: Contribution to journalLetterOther

Improving type 2 diabetes through a distinct adrenergic signaling pathway involving mTORC2 that mediates glucose uptake in skeletal muscle

Sato, M., Dehvari, N., Oberg, A., Dallner, O. S., Sandstrom, A. L., Olsen, J. M., Csikasz, R. I., Summers, R. J., Hutchinson, D. S. & Bengtsson, T., 2014, In : Diabetes. 63, 12, p. 4115 - 4129 15 p.

Research output: Contribution to journalArticleResearchpeer-review

Influenza A virus and TLR7 activation potentiate NOX2 oxidase-dependent ROS production in macrophages

To, E., Broughton, B. R. S., Hendricks, K. S., Vlahos, R. & Selemidis, S., 2014, In : Free Radical Research. 48, 8, p. 940 - 947 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Inhibition of presynaptic neurotoxins in taipan venom by suramin

Kuruppu, D. M. S., Chaisakul, J., Smith, A. I. & Hodgson, W. C., 2014, In : Neurotoxicity Research. 25, 3, p. 305 - 310 6 p.

Research output: Contribution to journalArticleResearchpeer-review

International union of basic and clinical pharmacology. XC. Multisite pharmacology: Recommendations for the nomenclature of receptor allosterism and allosteric ligands

Christopoulos, A., Changeux, J-P., Catterall, W. A., Fabbro, D., Burris, T. P., Cidlowski, J. A., Olsen, R. W., Peters, J. A., Neubig, R., Pin, J. P., Sexton, P., Kenakin, T. P., Ehlert, F. J., Spedding, M. & Langmead, C. J., 2014, In : Pharmacological Reviews. 66, 4, p. 918 - 947 30 p.

Research output: Contribution to journalArticleResearchpeer-review

Intranasally administered serelaxin abrogates airway remodelling and attenuates airway hyperresponsiveness in allergic airways disease

Royce, S. G., Lim, C., Patel, K. P., Wang, B., Samuel, C. S. & Tang, M. L. K., 2014, In : Clinical and Experimental Allergy. 44, 11, p. 1399 - 1408 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Intravenous immunoglobulin (IVIg) provides protection against endothelial cell dysfunction and death in ischemic stroke

Widiapradja, A., Santro, T., Basta, M., Sobey, C. G., Manzanero, S. & Arumugam, T., 2014, In : Experimental & Translational Stroke Medicine. 6, 1 (Art. No.: 7), p. 1 - 6 6 p.

Research output: Contribution to journalArticleResearchpeer-review

In-vitro neurotoxicity of two Malaysian krait species (Bungarus candidus and Bungarus fasciatus) venoms: neutralization by monovalent and polyvalent antivenoms from Thailand

Ahmad Rusmili, M. R., Tee, T. Y., Mustafa, M. R., Othman, I. & Hodgson, W. C., 2014, In : Toxins. 6, 3, p. 1036 - 1048 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

In vitro toxic effects of puff adder (Bitis arietans) venom, and their neutralization by antivenom

Fernandez, S., Hodgson, W. C., Chaisakul, J., Kornhauser, R. S., Konstantakopoulos, N., Smith, A. I. & Kuruppu, D. M. S., 2014, In : Toxins. 6, 5, p. 1586 - 1597 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Isolation and characterization of alpha-elapitoxin-Bf1b, a postsynaptic neurotoxin from Malaysian Bungarus fasciatus venom

Ahmad Rusmili, M. R., Tee, T. Y., Mustafa, M. R., Othman, I. & Hodgson, W. C., 2014, In : Biochemical Pharmacology. 88, 2, p. 229 - 236 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Isolation and characterization of a presynaptic neurotoxin, P-elapitoxin-Bf1a from Malaysian Bungarus fasciatus venom

Ahmad Rusmili, M. R., Tee, T. Y., Mustafa, M. R., Hodgson, W. C. & Othman, I., 2014, In : Biochemical Pharmacology. 91, 3, p. 409 - 416 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Localisation and activation of the neurokinin 1 receptor in the enteric nervous system of the mouse distal colon

Pelayo, J-C., Veldhuis, N. A., Eriksson, E. M., Bunnett, N. W. & Poole, D. P., 2014, In : Cell and Tissue Research. 356, 2, p. 319 - 332 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Localization of receptors for calcitonin-gene-related peptide to intraganglionic laminar endings of the mouse esophagus: Peripheral interaction between vagal and spinal afferents?

Horling, L., Bunnett, N. W., Messlinger, K., Neuhuber, W. L. & Raab, M., 2014, In : Histochemistry and Cell Biology. 141, 3, p. 321 - 335 15 p.

Research output: Contribution to journalArticleResearchpeer-review

Low-dose maternal alcohol consumption: effects in the hearts of offspring in early life and adulthood

Nguyen, V. B., Probyn, M. E., Campbell, F., Yin, K. V., Samuel, C. S., Zimanyi, M. A., Bertram, J. F., Black, M. J. & Moritz, K. M., 2014, In : Physiological Reports. 2, 7, p. 1 - 12 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Major contribution of the medial amygdala to hypertension in BPH/2J genetically hypertensive mice

Jackson, K. L., Palma-Rigo, K., Nguyen-Huu, T-P., Davern, P. J. & Head, G. A., 2014, In : Hypertension. 63, 4, p. 811 - 818 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Mechanistic insights into allosteric structure-function relationships at the M1 muscarinic acetylcholine receptor

Abdul Ridha, A., Lane, J. R. D., Mistry, S. N., Lopez Munoz, L., Sexton, P., Scammells, P. J., Christopoulos, A. & Canals, M., 2014, In : Journal of Biological Chemistry. 289, 48, p. 33701 - 33711 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Mechanistic insights into the contribution of epithelial damage to airway remodeling. Novel therapeutic targets for asthma

Royce, S. G., Li, X., Tortorella, S., Goodings, L. M., Chow, B. SM., Giraud, A. S., Tang, M. L. K. & Samuel, C. S., 2014, In : American Journal of Respiratory Cell and Molecular Biology. 50, 1, p. 180 - 192 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Molecular determinants of allosteric modulation at the M1 muscarinic acetylcholine receptor

Abdul Ridha, A., Lopez, L., Keov, P., Thal, D., Mistry, S. N., Sexton, P., Lane, J. R. D., Canals, M. & Christopoulos, A., 2014, In : Journal of Biological Chemistry. 289, 9, p. 6067 - 6079 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Molecular mechanisms of bitopic ligand engagement with the M1 muscarinic acetylcholine receptor

Keov, P., Lopez, L., Devine, S., Valant, C., Lane, J. R. D., Scammells, P. J., Sexton, P. & Christopoulos, A., 2014, In : Journal of Biological Chemistry. 289, 34, p. 23817 - 23837 21 p.

Research output: Contribution to journalArticleResearchpeer-review

Muscarinic acetylcholine receptors: Novel opportunities for drug development

Kruse, A. C., Kobilka, B., Gautam, D., Sexton, P. M., Christopoulos, A. & Wess, J., 2014, In : Nature Reviews Drug Discovery. 13, 7, p. 549 - 560 12 p.

Research output: Contribution to journalArticleResearchpeer-review

NADPH oxidases as novel pharmacologic targets against influenza A virus infection

Vlahos, R. & Selemidis, S., 2014, In : Molecular Pharmacology. 86, 6, p. 747 - 759 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Neural peptidase endothelin-converting enzyme 1 regulates endothelin 1-induced pruritus

Kido-Nakahara, M., Buddenkotte, J., Kempkes, C., Ikoma, A., Cevikbas, F., Akiyama, T., Nunes, F., Seeliger, S., Hasdemir, B., Mess, C., Buhl, T., Sulk, M., Muller, F-U., Metze, D., Bunnett, N. W., Bhargava, A., Carstens, E., Furue, M. & Steinhoff, M. S., 2014, In : Journal of Clinical Investigation. 124, 6, p. 2683 - 2695 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Neuro-humoral signalling by bile acids and the TGR5 receptor in the gastrointestinal tract

Bunnett, N. W., 2014, In : The Journal of Physiology. 592, 14, p. 2943 - 2950 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Novel therapeutic strategies for lung disorders associated with airway remodelling and fibrosis

Royce, S. G., Moodley, Y. & Samuel, C. S., 2014, In : Pharmacology and Therapeutics. 141, 3, p. 250 - 260 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Pharmacokinetics and pharmacodynamics of the myotoxic venom of Pseudechis australis (mulga snake) in the anesthetised rat

Hart, A. J., Hodgson, W. C., O'Leary, M. A. & Isbister, G. K., 2014, In : Clinical Toxicology. 52, 6, p. 604 - 610 7 p.

Research output: Contribution to journalArticleResearchpeer-review

PI3Kdelta inhibition reduces TNF secretion and neuroinflammation in a mouse cerebral stroke model

Low, P. C., Manzanero, S., Mohannak, N., Narayana, V. K., Nguyen, T. H., Kvaskoff, D., Brennan, F. H., Ruitenberg, M. J., Gelderblom, M., Magnus, T., Kim, H. H. A., Broughton, B. R. S., Sobey, C. G., Vanhaesebroeck, B., Stow, J. L., Arumugam, T. & Meunier, F. A., 2014, In : Nature Communications. 5, 3450, p. 1 - 12 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Potential efficacy of amnion epithelial cells to treat post-stroke inflammation

Broughton, B. R. S., Lim, R. S. W., Evans, M. A., Drummond, G. R., Wallace, E. M. & Sobey, C. G., 2014, Perinatal Stem Cells. Atala, A. & Murphy, S. V. (eds.). 1st ed. USA: Springer, p. 219 - 229 11 p.

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Researchpeer-review

Open Access
File

Prolonged calcitonin receptor signaling by salmon, but not human calcitonin, reveals ligand bias

Andreassen, K. V., Hjuler, S. T., Furness, S. G. B., Sexton, P. M., Christopoulos, A., Nosjean, O., Karsdal, M. A. & Henriksen, K., 2014, In : PLoS ONE. 9, 3 (Art. No: e92042), p. 1 - 10 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File

Proteolytic activation of the human epithelial sodium channel by trypsin IV and trypsin I involves distinct cleavage sites

Haerteis, S., Krappitz, A., Krappitz, M., Murphy, J. E., Bertog, M., Krueger, B., Nacken, R., Chung, H., Hollenberg, M. D., Knecht, W., Bunnett, N. W. & Korbmacher, C., 2014, In : Journal of Biological Chemistry. 289, 27, p. 19067 - 19078 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Proteomic analysis of Moroccan cobra Naja haje legionis venom using tandem mass spectrometry

Malih, I., Ahmad Rusmili, M. R., Tee, T. Y., Saile, R., Ghalim, N. & Othman, I., 2014, In : Journal of Proteomics. 96, p. 240 - 252 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Proteomic characterization and comparison of Malaysian Bungarus candidus and Bungarus fasciatus venoms

Ahmad Rusmili, M. R., Tee, T. Y., Mustafa, M. R., Hodgson, W. C. & Othman, I., 2014, In : Journal of Proteomics. 110, p. 129 - 144 16 p.

Research output: Contribution to journalArticleResearchpeer-review

Qualitative and quantitative analysis of fibrosis in the kidney

Hewitson, T. D., Smith, E. R. & Samuel, C. S., 2014, In : Nephrology. 19, 11, p. 721 - 726 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Quantification of ligand bias for clinically relevant beta2-adrenergic receptor ligands: Implications for drug taxonomy

van der Westhuizen, E. T., Breton, B., Christopoulos, A. & Bouvier, M., 2014, In : Molecular Pharmacology. 85, 3, p. 492 - 509 18 p.

Research output: Contribution to journalArticleResearchpeer-review

Reactive oxygen species and cerebrovascular diseases

Miller, A. A., De Silva, T. M., Drummond, G. R., Sobey, C. G. & Chrissobolis, S., 2014, Systems Biology of Free Radicals and Antioxidants. Laher, I. (ed.). 1st ed. Germany: Springer, p. 1895 - 1924 30 p.

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Researchpeer-review

Relaxin-3 mRNA levels in nucleus incertus correlate with alcohol and sucrose intake in rats

Ryan, P. J., Krstew, E. V., Sarwar, M., Gundlach, A. L. & Lawrence, A. J., 1 Jul 2014, In : Drug and Alcohol Dependence. 140, p. 8-16 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Relaxin requires the angiotensin II type 2 receptor to abrogate renal interstitial fibrosis

Chow, B. SM., Kocan, M., Bosnyak, S., Sarwar, M., Wigg, B., Jones, E. S., Widdop, R. E., Summers, R. J., Bathgate, R. A. D., Hewitson, T. D. & Samuel, C. S., 2014, In : Kidney International. 86, 1, p. 75 - 85 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Risk factors for eosinophilic esophagitis

Philpott, H., Nandurkar, S., Royce, S. G., Thien, F. & Gibson, P. R., 2014, In : Clinical and Experimental Allergy. 44, 8, p. 1012 - 1019 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Role of caveolin-1 in asthma and chronic inflammatory respiratory diseases

Royce, S. G. & Le Saux, C. J., 2014, In : Expert Review of Respiratory Medicine. 8, 3, p. 339 - 347 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Role of CCR2 in inflammatory conditions of the central nervous system

Chu, H., Arumugam, T., Gelderblom, M., Magnus, T., Drummond, G. R. & Sobey, C. G., 2014, In : Journal of Cerebral Blood Flow and Metabolism. 34, 9, p. 1425 - 1429 5 p.

Research output: Contribution to journalArticleResearchpeer-review