Research Output 1986 2019

2014

Proteolytic activation of the human epithelial sodium channel by trypsin IV and trypsin I involves distinct cleavage sites

Haerteis, S., Krappitz, A., Krappitz, M., Murphy, J. E., Bertog, M., Krueger, B., Nacken, R., Chung, H., Hollenberg, M. D., Knecht, W., Bunnett, N. W. & Korbmacher, C., 2014, In : Journal of Biological Chemistry. 289, 27, p. 19067 - 19078 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Proteomic analysis of Moroccan cobra Naja haje legionis venom using tandem mass spectrometry

Malih, I., Ahmad Rusmili, M. R., Tee, T. Y., Saile, R., Ghalim, N. & Othman, I., 2014, In : Journal of Proteomics. 96, p. 240 - 252 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Proteomic characterization and comparison of Malaysian Bungarus candidus and Bungarus fasciatus venoms

Ahmad Rusmili, M. R., Tee, T. Y., Mustafa, M. R., Hodgson, W. C. & Othman, I., 2014, In : Journal of Proteomics. 110, p. 129 - 144 16 p.

Research output: Contribution to journalArticleResearchpeer-review

Qualitative and quantitative analysis of fibrosis in the kidney

Hewitson, T. D., Smith, E. R. & Samuel, C. S., 2014, In : Nephrology. 19, 11, p. 721 - 726 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Quantification of ligand bias for clinically relevant beta2-adrenergic receptor ligands: Implications for drug taxonomy

van der Westhuizen, E. T., Breton, B., Christopoulos, A. & Bouvier, M., 2014, In : Molecular Pharmacology. 85, 3, p. 492 - 509 18 p.

Research output: Contribution to journalArticleResearchpeer-review

Reactive oxygen species and cerebrovascular diseases

Miller, A. A., De Silva, T. M., Drummond, G. R., Sobey, C. G. & Chrissobolis, S., 2014, Systems Biology of Free Radicals and Antioxidants. Laher, I. (ed.). 1st ed. Germany: Springer, p. 1895 - 1924 30 p.

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Researchpeer-review

Relaxin-3 mRNA levels in nucleus incertus correlate with alcohol and sucrose intake in rats

Ryan, P. J., Krstew, E. V., Sarwar, M., Gundlach, A. L. & Lawrence, A. J., 1 Jul 2014, In : Drug and Alcohol Dependence. 140, p. 8-16 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Relaxin requires the angiotensin II type 2 receptor to abrogate renal interstitial fibrosis

Chow, B. SM., Kocan, M., Bosnyak, S., Sarwar, M., Wigg, B., Jones, E. S., Widdop, R. E., Summers, R. J., Bathgate, R. A. D., Hewitson, T. D. & Samuel, C. S., 2014, In : Kidney International. 86, 1, p. 75 - 85 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Risk factors for eosinophilic esophagitis

Philpott, H., Nandurkar, S., Royce, S. G., Thien, F. & Gibson, P. R., 2014, In : Clinical and Experimental Allergy. 44, 8, p. 1012 - 1019 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Role of caveolin-1 in asthma and chronic inflammatory respiratory diseases

Royce, S. G. & Le Saux, C. J., 2014, In : Expert Review of Respiratory Medicine. 8, 3, p. 339 - 347 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Role of CCR2 in inflammatory conditions of the central nervous system

Chu, H., Arumugam, T., Gelderblom, M., Magnus, T., Drummond, G. R. & Sobey, C. G., 2014, In : Journal of Cerebral Blood Flow and Metabolism. 34, 9, p. 1425 - 1429 5 p.

Research output: Contribution to journalArticleResearchpeer-review

Roles of inflammation, oxidative stress, and vascular dysfunction in hypertension

Dinh, Q. N., Drummond, G. R., Sobey, C. G. & Chrissobolis, S., 2014, In : BioMed Research International. 2014, 406960, p. 1 - 11 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Roles of intraloops-2 and -3 and the proximal C-terminus in signalling pathway selection from the human calcium-sensing receptor

Goolam, M. A., Ward, J. H., Avlani, V. A., Leach, K., Christopoulos, A. & Conigrave, A., 2014, In : FEBS Letters. 588, 18, p. 3340 - 3346 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Serelaxin is a more efficacious antifibrotic than enalapril in an experimental model of heart disease

Samuel, C. S., Bodaragama, H., Chew, J., Widdop, R. E., Royce, S. G. & Hewitson, T. D., 2014, In : Hypertension. 64, 2, p. 315 - 322 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Serine proteases and protease-activated receptor 2 mediate the proinflammatory and algesic actions of diverse stimulants

Cattaruzza, F., Amadesi, S., Carlsson, J. F., Murphy, J. E., Lyo, V., Kirkwood, K. S., Cottrell, G. S., Bogyo, M., Knecht, W. & Bunnett, N. W., 2014, In : British Journal of Pharmacology. 171, 16, p. 3814 - 3826 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Sex-and age-related differences in the chronic pressure-natriuresis relationship: role of the angiotensin type 2 receptor

Mirabito, K. M., Hilliard, L. M., Kett, M. M., Brown, R. D., Booth, S. C., Widdop, R. E., Moritz, K. M., Evans, R. G. & Denton, K. M., 2014, In : American Journal of Physiology - Renal Physiology. 307, 8, p. 901 - 907 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Sex-dependent effects of G protein-coupled estrogen receptor activity on outcome after ischemic stroke

Broughton, B. R. S., Brait, V. H., Kim, H. H. A., Lee, S. S., Chu, H. X., Gardiner-Mann, C. V., Guida, E., Evans, M. A., Miller, A. A., Arumugam, T., Drummond, G. R. & Sobey, C. G., 2014, In : Stroke. 45, 3, p. 835 - 841 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Short term fat feeding rapidly increases plasma insulin but does not result in dyslipidaemi

Barzel, B., Weir, J. M., Meikle, P. J., Burke, S. L., Armitage, J. & Head, G. A., 2014, In : Frontiers in Physiology. 5, (Art. No: 469), p. 1 - 8 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Signalling profiles of H3 relaxin, H2 relaxin and R3(B?23-27)R/I5 acting at the relaxin family peptide receptor 3 (RXFP3)

Kocan, M., Sarwar, M., Hossain, M. A., Wade, J. D. & Summers, R. J., 2014, In : British Journal of Pharmacology. 171, 11, p. 2827 - 2841 15 p.

Research output: Contribution to journalArticleResearchpeer-review

Structural and functional insights into the juxtamembranous amino-terminal tail and extracellular loop regions of class B GPCRs

Dong, M., Koole, C. R., Wootten, D. L., Sexton, P. & Miller, L. J., 2014, In : British Journal of Pharmacology. 171, 5, p. 1085 - 1101 17 p.

Research output: Contribution to journalArticleResearchpeer-review

Structure-activity relationships of privileged structures lead to the discovery of novel biased ligands at the dopamine D2 receptor

Szabo, M., Klein Herenbrink, C., Christopoulos, A., Lane, J. R. D. & Capuano, B., 2014, In : Journal of Medicinal Chemistry. 57, 11, p. 4924 - 4939 16 p.

Research output: Contribution to journalArticleResearchpeer-review

Tachykinins and their receptors: Contributions to physiological control and the mechanisms of disease

Steinhoff, M. S., von Mentzer, B., Geppetti, P., Pothoulakis, C. & Bunnett, N. W., 2014, In : Physiological Reviews. 94, 1, p. 265 - 301 37 p.

Research output: Contribution to journalArticleResearchpeer-review

The bile acid receptor TGR5 activates the TRPA1 channel to induce itch in mice

Lieu, T. M., Jayaweera, G., Zhao, P., Poole, D. P., Jensen, D. D., Grace, M., McIntyre, P., Bron, R., Wilson, Y., Krappitz, M., Haerteis, S., Korbmacher, C., Steinhoff, M. S., Nassini, R., Materazzi, S., Geppetti, P., Corvera, C. U. & Bunnett, N. W., 2014, In : Gastroenterology. 147, 6, p. 1417 - 1428 12 p.

Research output: Contribution to journalArticleResearchpeer-review

The class B G-protein-coupled GLP-1 receptor: an important target for the treatment of type-2 diabetes mellitus

Miller, L. J., Sexton, P. M., Dong, M. & Harikumar, K. G., 2014, In : International Journal of Obesity. 4, p. S9-S13 5 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

The effect of gas exchange on multiple-breath nitrogen washout measures of ventilation inhomogeneity in the mouse

Dharmakumara, M., Prisk, G. K., Royce, S. G., Tawhai, M. & Thompson, B. R., 2014, In : Journal of Applied Physiology. 117, 9, p. 1049 - 1054 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Themed issue of the British Journal of Pharmacology

Summers, R. J., 2014, In : British Journal of Pharmacology. 171, 5, p. 1069 - 1072 4 p.

Research output: Contribution to journalLetterOther

The protective arms of the renin-angiontensin system in stroke

McCarthy, C. A., Facey, L. J. & Widdop, R. E., 2014, In : Current Hypertension Reports. 16, 7 (Art. No: 440), p. 1 - 8 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Therapeutic effects of serelaxin in acute heart failure

Du, X-J., Hewitson, T. D., Nguyen, M-N. & Samuel, C. S., 2014, In : Circulation Journal. 78, 3, p. 542 - 552 11 p.

Research output: Contribution to journalArticleResearchpeer-review

The tyrosine kinase inhibitor bafetinib inhibits PAR2-induced activation of TRPV4 channels in vitro and pain in vivo

Grace, M., Lieu, T. M., Darby, B., Abogadie, F. C., Veldhuis, N. A., Bunnett, N. W. & McIntyre, P., 2014, In : British Journal of Pharmacology. 171, 16, p. 3881 - 3894 14 p.

Research output: Contribution to journalArticleResearchpeer-review

TLR2 activation causes tachyphylaxis to β2-Agonists in vitro and ex vivo: Modelling bacterial exacerbation

Alkhouri, H., Rumzhum, N. N., Rahman, M. M., Fitzpatrick, M., De Pedro, M., Oliver, B. G., Bourke, J. E. & Ammit, A. J., Sep 2014, In : Allergy. 69, 9, p. 1215-1222 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Understanding the biology of reactive oxygen species and their link to cancer: NADPH oxidases as novel pharmacological targets

Harrison, I. & Selemidis, S., 2014, In : Clinical and Experimental Pharmacology and Physiology. 41, 8, p. 533 - 542 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Unexpected anti-hypertrophic responses to low-level stimulation of protease-activated receptors in adult rat cardiomyocytes

Fender, A. C., Pavic, G., Drummond, G. R., Dusting, G. J. & Ritchie, R. H., 2014, In : Naunyn-Schmiedeberg's Archives of Pharmacology. 387, 10, p. 1001 - 1007 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Vasoactive role for angiotensin II type 2 receptors in human radial artery

Zulli, A., Hare, D. L., Buxton, B. F. & Widdop, R. E., 2014, In : International Journal of Immunopathology and Pharmacology. 27, 1, p. 79 - 85 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Vintage venoms: proteomic and pharmacological stability of snake venoms stored for up to eight decades

Jesupret, C., Baumann, K., Jackson, T. N. W., Ali, S. A., Yang, D., Greisman, L., Kern, L., Steuten, J. A., Jouiaei, M., Casewell, N. R., Undheim, E. A. B., Koludarov, I., Debono, J., Low, D. H. W., Rossi, S., Panagides, N., Winter, K. L., Ignjatovic, V., Summerhayes, R., Jones, A. & 6 othersNouwens, A. S., Dunstan, N., Hodgson, W. C., Winkel, K., Monagle, P. & Fry, B., 2014, In : Journal of Proteomics. 105, p. 285 - 294 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Accumulation of serum lipids by vascular smooth muscle cells involves a macropinocytosis-like uptake pathway and is associated with the downregulation of the ATP-binding cassette transporter A1

Rivera, J., Walduck, A., Thomas, S. R., Glaros, E. N., Hooker, E. U., Guida, E., Sobey, C. G. & Drummond, G. R., 2013, In : Naunyn-Schmiedeberg's Archives of Pharmacology. 386, 12, p. 1081 - 1093 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Activation and allosteric modulation of a muscarinic acetylcholine receptor

Kruse, A. C., Ring, A. M., Manglik, A., Hu, J., Hu, K., Eitel, K., Hubner, H., Pardon, E., Valant, C., Sexton, P., Christopoulos, A., Felder, C. C., Gmeiner, P., Steyaert, J., Weis, W., Garcia, K. C., Wess, J. & Kobilka, B., 2013, In : Nature. 504, 7478, p. 101 - 106 6 p.

Research output: Contribution to journalArticleResearchpeer-review

A flow cytometric method for the analysis of macrophages in the vascular wall

Moore, J., Sakkal, S., Bullen, M. L., Harper, B. K., Ricardo, S. D., Sobey, C. G. & Drummond, G. R., 2013, In : Journal of Immunological Methods. 396, 1-2, p. 33 - 43 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Allosteric approaches to GPCR drug discovery

Lane, J. R. & Ijzerman, A. P., 2013, In : Drug Discovery Today: Technologies. 10, 2

Research output: Contribution to journalEditorialOtherpeer-review

Allosteric modulation of a chemogenetically modified G protein-coupled receptor

Abdul Ridha, A., Lane, J. R. D., Sexton, P., Canals, M. & Christopoulos, A., 2013, In : Molecular Pharmacology. 83, 2, p. 521 - 530 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Alpha neurotoxins

Barber, C. M., Isbister, G. K. & Hodgson, W. C., 2013, In : Toxicon : official journal of the International Society on Toxinology. 66, p. 47 - 58 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Amine oxidase activity of beta-amyloid precursor protein modulates systemic and local catecholamine levels

Duce, J. A., Ayton, S., Miller, A. A., Tsatsanis, A., Lam, L. Q., Leone, L., Corbin, J. E., Butzkueven, H., Kilpatrick, T., Rogers, J. T., Barnham, K. J., Finkelstein, D. I. & Bush, A. I., 2013, In : Molecular Psychiatry. 18, 2, p. 245 - 254 10 p.

Research output: Contribution to journalArticleResearchpeer-review

An assessment of the in vivo effects of intravenous lipid emulsion on blood drug concentration and haemodynamics following oro-gastric amitriptyline overdose

Perichon, D., Turfus, S. C., Gerostamoulos, D. & Graudins, A., 2013, In : Clinical Toxicology. 51, 4, p. 208 - 215 8 p.

Research output: Contribution to journalArticleResearchpeer-review

An evaluation of pharmacology curricula in Australian science and health-related degree programs

Lloyd, H. GE., Hinton, T., Bullock, S. P., Babey, A-M., Davis, E. A., Fernandes, L., Hart, J., Musgrave, I. & Ziogas, J., 2013, In : BMC Medical Education. 13, Art. No.:153, p. 1 - 15 15 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File

An examination of cardiovascular collapse induced by eastern brown snake (Pseudonaja textilis) venom

Chaisakul, J., Isbister, G. K., Kuruppu, D. M. S., Konstantakopoulos, N. & Hodgson, W. C., 2013, In : Toxicology Letters. 221, 3, p. 205 - 211 7 p.

Research output: Contribution to journalArticleResearchpeer-review