Research Output

2015

Nitroxyl: a vasodilator of human vessels that is not susceptible to tolerance

Andrews, K. L., Lumsden, N. G., Farry, J., Jefferis, A-M., Kemp-Harper, B. K. & Chin-Dusting, J. P. F., 2015, In : Clinical Science. 129, 2, p. 179 - 187 9 p.

Research output: Contribution to journalArticleResearchpeer-review

22 Citations (Scopus)

Nontypeable Haemophilus influenzae induces sustained lung oxidative stress and protease expression

King, P. T., Sharma, R., O'Sullivan, K., Selemidis, S., Lim, S., Radhakrishna, N., Lo, C. Y-W., Prasad, J., Callaghan, J. M., McLaughlin, P., Farmer, M., Steinfort, D. P., Jennings, B. R., Ngui, J., Broughton, B. R. S., Thomas, B., Essilfie, A-T., Hickey, M. J., Holmes, P., Hansbro, P. M. & 2 others, Bardin, P. G. & Holdsworth, S. R., 2015, In : PLoS ONE. 10, 3 (Art. No.: e0120371), p. 1 - 17 17 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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17 Citations (Scopus)

Novel allosteric modulators of G protein-coupled receptors

Gentry, P. R., Sexton, P. M. & Christopoulos, A., 2015, In : The Journal of Biological Chemistry. 290, 32, p. 19478-19488 11 p.

Research output: Contribution to journalArticleResearchpeer-review

95 Citations (Scopus)

Novel GPCR paradigms at the μ-opioid receptor

Thompson, G. L., Kelly, E., Christopoulos, A. & Canals, M., 2015, In : British Journal of Pharmacology. 172, 2, p. 287-296 10 p.

Research output: Contribution to journalArticleResearchpeer-review

40 Citations (Scopus)
21 Citations (Scopus)

Nox1 upregulates the function of vascular T-type calcium channels following chronic nitric oxide deficit

Howitt, L., Matthaei, K. I., Drummond, G. R. & Hill, C. E., 2015, In : Pflugers Archiv-European Journal of Physiology. 467, 4, p. 727 - 735 9 p.

Research output: Contribution to journalArticleResearchpeer-review

4 Citations (Scopus)

Obligatory role for B cells in the development of angiotensin II-dependent hypertension

Chan, C. T-L., Sobey, C. G., Lieu, M., Ferens, D. M., Kett, M. M., Diep, H., Kim, H. H. A., Krishnan, S. M., Lewis, C. V., Salimova, E., Tipping, P. G., Vinh, A., Samuel, C. S., Peter, K., Guzik, T. J., Kyaw, T. S., Toh, B-H., Bobik, A. & Drummond, G. R., 2015, In : Hypertension. 66, 5, p. 1023 - 1033 11 p.

Research output: Contribution to journalArticleResearchpeer-review

80 Citations (Scopus)

P2Y1 receptor activation of the TRPV4 ion channel enhances purinergic signaling in satellite glial cells

Rajasekhar, P., Poole, D. P., Liedtke, W., Bunnett, N. W. & Veldhuis, N. A., 2015, In : The Journal of Biological Chemistry. 290, 48, p. 29051-29062 12 p.

Research output: Contribution to journalArticleResearchpeer-review

23 Citations (Scopus)

PcTx1 affords neuroprotection in a conscious model of stroke in hypertensive rats via selective inhibition of ASIC1a

McCarthy, C. A., Rash, L. D., Chassagnon, I. R., King, G. F. & Widdop, R. E., 2015, In : Neuropharmacology. 99, (Art. No: 5986), p. 650 - 657 8 p.

Research output: Contribution to journalArticleResearchpeer-review

24 Citations (Scopus)

Pin1 promotes neuronal death in stroke by stabilizing Notch intracellular domain

Baik, S-H., Fane, M., Park, J. H., Cheng, Y-L., Fann, D. Y-W., Yun, U. J., Choi, Y., Park, J-S., Chai, B. H., Park, J. S., Back, S. H., Jeong, J. I., Jang, Y. J., Bahn, G., Lee, J-Y., Li, Y., Sobey, C. G., Uchida, T., Park, J. H., Kim, H. T. & 3 others, Tang, S-C., Arumugam, T. V. & Jo, D-G., 2015, In : Annals of Neurology. 77, 3, p. 504 - 516 13 p.

Research output: Contribution to journalArticleResearchpeer-review

37 Citations (Scopus)

Proof of concept study for designed multiple ligands targeting the dopamine D2, serotonin 5-HT2A, and muscarinic M1 acetylcholine receptors

Szabo, M., Lim, H. D., Klein Herenbrink, C., Christopoulos, A., Lane, J. R. D. & Capuano, B., 2015, In : Journal of Medicinal Chemistry. 58, 3, p. 1550 - 1555 6 p.

Research output: Contribution to journalArticleResearchpeer-review

7 Citations (Scopus)

Quantification and potential functions of endogenous agonists of transient receptor potential channels in patients with irritable bowel syndrome

Cenac, N., Bautzova, T., Le Faouder, P., Veldhuis, N. A., Poole, D. P., Rolland, C., Bertrand, J., Liedtke, W., Dubourdeau, M., Bertrand-Michel, J., Zecchi, L., Stanghellini, V., Bunnett, N. W., Barbara, G. & Vergnolle, N., 2015, In : Gastroenterology. 149, 2, p. 433-444 12 p.

Research output: Contribution to journalArticleResearchpeer-review

69 Citations (Scopus)

Receptor expression modulates calcium-sensing receptor mediated intracellular Ca2+ mobilization

Brennan, S. C., Mun, H., Leach, K., Kuchel, P. W., Christopoulos, A. & Conigrave, A., 2015, In : Endocrinology. 156, 4, p. 1330 - 1342 13 p.

Research output: Contribution to journalArticleResearchpeer-review

16 Citations (Scopus)

Risk of major cardiovascular events in people with down syndrome

Sobey, C. G., Judkins, C. P., Sundararajan, V., Phan, T. G., Drummond, G. R. & Srikanth, V. K., 2015, In : PLoS ONE. 10, 9, 11 p., e0137093.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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47 Citations (Scopus)

Rosiglitazone elicits in vitro relaxation in airways and precision cut lung slices from a mouse model of chronic allergic airways disease

Donovan, C., Bailey, S. R., Tran, J., Haitsma, G., Ibrahim, Z. A., Foster, S. R., Tang, M. L. K., Royce, S. G. & Bourke, J. E., 2015, In : American Journal of Physiology - Lung Cellular and Molecular Physiology. 309, 10, p. 1219 - 1228 10 p.

Research output: Contribution to journalArticleResearchpeer-review

13 Citations (Scopus)

Seasonal recurrence of food bolus obstruction in eosinophilic esophagitis

Philpott, H., Nandurkar, S., Thien, F. C. K., Bloom, S. D., Lin, E., Goldberg, R., Boyapati, R., Finch, A., Royce, S. G. & Gibson, P. R., 2015, In : Internal Medicine Journal. 45, 9, p. 939 - 943 5 p.

Research output: Contribution to journalArticleResearchpeer-review

23 Citations (Scopus)

Sensitisation of TRPV4 by PAR2 is independent of intracellular calcium signalling and can be mediated by the biased agonist neutrophil elastase

Sostegni, S., Diakov, A., McIntyre, P., Bunnett, N., Korbmacher, C. & Haerteis, S., 2015, In : Pflugers Archiv-European Journal of Physiology. 467, 4, p. 687-701 15 p.

Research output: Contribution to journalArticleResearchpeer-review

9 Citations (Scopus)

Serelaxin-mediated signal transduction in human vascular cells: bell-shaped concentration-response curves reflect differential coupling to G proteins

Sarwar, M., Samuel, C. S., Bathgate, R. A., Stewart, D. R. & Summers, R. J., 2015, In : British Journal of Pharmacology. 172, 4, p. 1005-1019 15 p.

Research output: Contribution to journalArticleResearchpeer-review

41 Citations (Scopus)

Sex differences in AT2R expression and action

Hilliard, L. M., Mirabito, K. M., Widdop, R. E. & Denton, K. M., 2015, The Protective Arm of the Renin-Angiotensin System: Functional Aspects and Therapeutic Implications. Unger, T., Steckelings, U. M. & dos Santos, R. A. S. (eds.). 1st ed. London UK: Elsevier, p. 125 - 130 6 p.

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Researchpeer-review

Specific role of dietary fat in modifying cardiovascular and locomotor activity 24-h rhythms

Barzel, B., Lim, K. J., Burke, S. L., Armitage, J. A. & Head, G. A., 2015, In : Chronobiology International. 32, 5, p. 668 - 676 9 p.

Research output: Contribution to journalArticleResearchpeer-review

3 Citations (Scopus)

Stonefish toxin defines an ancient branch of the perforin-like superfamily

Ellisdon, A. M., Reboul, C. F., Panjikar, S., Huynh, K., Oellig, C. A., Winter, K. L., Dunstone, M. A., Hodgson, W. C., Seymour, J. E., Dearden, P. K., Tweten, R. K., Whisstock, J. C. & McGowan, S., 2015, In : Proceedings of the National Academy of Sciences of the United States of America. 112, 50, p. 15360 - 15365 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
22 Citations (Scopus)

Structural and functional correlations in a large animal model of bleomycin-induced pulmonary fibrosis

Organ, L., Bacci, B., Koumoundouros, E., Barcham, G. J., Milne, M., Kimpton, W. G., Samuel, C. S. & Snibson, K. J., 2015, In : BMC Pulmonary Medicine. 15, 1 , 15 p., 81.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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17 Citations (Scopus)

Structural determinants for binding to angiotensin converting enzyme 2 (ACE2) and angiotensin receptors 1 and 2

Clayton, D. J., Hanchapola, I., Thomas, W. G., Widdop, R. E., Smith, A. I., Perlmutter, P. & Aguilar, M. M. I. . I., 2015, In : Frontiers in Pharmacology. 6, (Art. No: 5), p. 1 - 9 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
8 Citations (Scopus)
25 Citations (Scopus)

Synthesis and pharmacological evaluation of M4 muscarinic receptor positive allosteric modulators derived from VU10004

Huynh, T., Valant, C., Crosby, I. T., Sexton, P., Christopoulos, A. & Capuano, B., 2015, In : ACS Chemical Neuroscience. 6, 6, p. 838 - 844 7 p.

Research output: Contribution to journalArticleResearchpeer-review

9 Citations (Scopus)

Synthesis of six mexiletine derivatives with isoindolines attached as potential antioxidants and their evaluation as cardioprotective agents

Chau, B. A., Drummond, G. R., Jackson, W. R., Jarrott, B., Miller, A. A., Subasinghe, K. R., Tan, C. Y. R., White, P. J., Wright, C. E. & Ziogas, J., 2015, In : MedChemComm. 6, 4, p. 634-639 6 p.

Research output: Contribution to journalArticleResearchpeer-review

2 Citations (Scopus)

Synthetic covalently linked dimeric form of H2 relaxin retains native RXFP1 activity and has improved in vitro serum stability

Nair, V. B., Bathgate, R. A. D., Separovic, F., Samuel, C. S., Hossain, M. A. & Wade, J. D., 2015, In : BioMed Research International. 2015, 10 p., 731852.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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6 Citations (Scopus)

Targeting of transient receptor potential channels in digestive disease

Poole, D. P., Lieu, T., Veldhuis, N. A., Rajasekhar, P. & Bunnett, N. W., 2015, TRP Channels as Therapeutic Targets: From Basic Science to Clinical Use. Szallasi, A. (ed.). London UK: Elsevier, p. 385-403 19 p.

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Researchpeer-review

1 Citation (Scopus)

The G protein-coupled receptor-transient receptor potential channel axis: molecular insights for targeting disorders of sensation and inflammation

Veldhuis, N. A., Poole, D. P., Grace, M., McIntyre, P. & Bunnett, N. W., 2015, In : Pharmacological Reviews. 67, 1, p. 36 - 73 38 p.

Research output: Contribution to journalArticleResearchpeer-review

66 Citations (Scopus)

Towards tissue-specific pharmacology: insights from the calcium-sensing receptor as a paradigm for GPCR (patho)physiological bias

Leach, K., Conigrave, A. D., Sexton, P. M. & Christopoulos, A., 2015, In : Trends in Pharmacological Sciences. 36, 4, p. 215-225 11 p.

Research output: Contribution to journalArticleResearchpeer-review

34 Citations (Scopus)

Transient receptor potential vanilloid 4 inhibits mouse colonic motility by activating NO-dependent enteric neurotransmission

Fichna, J., Poole, D. P., Veldhuis, N., MacEachern, S. J., Saur, D., Zakrzewski, P. K., Cygankiewicz, A. I., Mokrowiecka, A., Malecka-Panas, E., Krajewska, W. M., Liedtke, W., Steinhoff, M. S., Timmermans, J-P., Bunnett, N. W., Sharkey, K. A. & Storr, M. A., 2015, In : Journal of Molecular Medicine. 93, 12, p. 1297-1309 13 p.

Research output: Contribution to journalArticleResearchpeer-review

12 Citations (Scopus)

Venoms-Based Drug Discovery: Bioassays, Electrophysiology, High-Throughput Screens and Target Identification

Vetter, I., Hodgson, W. C., Adams, D. J. & McIntyre, P., 2015, Venoms to Drugs : Venom as a Source for the Development of Human Therapeutics. King, G. F. (ed.). 1st ed. UK: The Royal Society of Chemistry, p. 97 - 128 32 p.

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Otherpeer-review

5 Citations (Scopus)

What gastroenterologists should know about testing patients with eosinophilic esophagitis for food allergies

Philpott, H., Royce, S. G., Thien, F. C. K., Nandurkar, S. & Gibson, P. R., 2015, In : Clinical Gastroenterology and Hepatology. 13, 5, p. 1029 - 1030 2 p.

Research output: Contribution to journalLetterOtherpeer-review

β2-adrenoceptor signaling regulates invadopodia formation to enhance tumor cell invasion

Creed, S. J., Le, C. P., Hassan, M., Pon, C. K., Albold, S., Chan, K. T., Berginski, M. E., Huang, Z., Bear, J. E., Lane, J. R., Halls, M. L., Ferrari, D., Nowell, C. J. & Sloan, E. K., 2015, In : Breast Cancer Research. 17, 1, 12 p., 145.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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33 Citations (Scopus)

β-Pro7Ang III is a novel highly selective angiotensin II type 2 receptor (AT2R) agonist, which acts as a vasodepressor agent via the AT2R in conscious spontaneously hypertensive rats

Del Borgo, M. P., Wang, Y., Bosnyak, S., Walters, P. E., Spizzo, I., Perlmutter, P., Hilliard, L. M., Denton, K. M., Aguilar, M-I. M., Widdop, R. E. & Jones, E. S., 2015, In : Clinical Science. 129, 6, p. 505 - 513 9 p.

Research output: Contribution to journalArticleResearchpeer-review

16 Citations (Scopus)
2014

Actions of rilmenidine on neurogenic hypertension in BPH/2J genetically hypertensive mice

Jackson, K. L., Palma-Rigo, K., Nguyen-Huu, T-P. & Head, G. A., 2014, In : Journal of Hypertension. 32, 3, p. 575 - 586 12 p.

Research output: Contribution to journalArticleResearchpeer-review

5 Citations (Scopus)

Activation of mu opioid receptors sensitizes Transient Receptor Potential Vanilloid Type 1 (TRPV1) via beta-arrestin-2-mediated cross-talk

Rowan, M. P., Bierbower, S. M., Eskander, M. A., Szteyn, K., Por, E. D., Gomez, R., Veldhuis, N. A., Bunnett, N. W. & Jeske, N. A., 2014, In : PLoS ONE. 9, 4, 12 p., e93688.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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28 Citations (Scopus)

Advances in G protein-coupled receptor allostery: From function to structure

Christopoulos, A., 2014, In : Molecular Pharmacology. 86, 5, p. 463 - 478 16 p.

Research output: Contribution to journalArticleResearchpeer-review

123 Citations (Scopus)

Allosteric interactions at adenosine A1 and A3 receptors: New insights into the role of small molecules and receptor dimerization

Hill, S. J., May, L. T., Kellam, B. & Woolard, J., 2014, In : British Journal of Pharmacology. 171, 5, p. 1102 - 1113 12 p.

Research output: Contribution to journalArticleResearchpeer-review

38 Citations (Scopus)

Allosteric modulation of M1 muscarinic acetylcholine receptor internalization and subcellular trafficking

Yeatman, H. R., Lane, J. R. D., Choy, K. H. C., Lambert, N., Sexton, P., Christopoulos, A. & Canals, M., 2014, In : The Journal of Biological Chemistry. 289, 22, p. 15856 - 15866 11 p.

Research output: Contribution to journalArticleResearchpeer-review

19 Citations (Scopus)

Allosteric targeting of receptor tyrosine kinases

De Smet, F., Christopoulos, A. & Carmeliet, P., 2014, In : Nature Biotechnology. 32, 11, p. 1113 - 1120 8 p.

Research output: Contribution to journalArticleResearchpeer-review

40 Citations (Scopus)

A new mechanism of allostery in a G protein-coupled receptor dimer

Lane, J. R. D., Donthamsetti, P., Shonberg, J., Draper-Joyce, C. J., Dentry, S., Michino, M., Shi, L., Lopez Munoz, L., Scammells, P. J., Capuano, B., Sexton, P., Javitch, J. A. & Christopoulos, A., 2014, In : Nature Chemical Biology. 10, 9, p. 745 - 752 8 p.

Research output: Contribution to journalArticleResearchpeer-review

81 Citations (Scopus)

Angiotensin (1-7) as a Therapy to Prevent Rupture of Intracranial Aneurysms?

Kuruppu, D. M. S., Smith, A. I., Drummond, G. R. & Sobey, C. G., 2014, In : Hypertension. 64, 2, p. 222 - 223 2 p.

Research output: Contribution to journalLetterOther

1 Citation (Scopus)

Angiotensin-converting enzyme 2 mediates hyperfiltration associated with diabetes

Tikellis, C., Brown, R., Head, G. A., Cooper, M. E. & Thomas, M. C., 1 Apr 2014, In : American Journal of Physiology-Renal Physiology. 306, 7, p. F773 - F780 8 p.

Research output: Contribution to journalArticleResearchpeer-review

18 Citations (Scopus)

Angiotensin type 2 receptor stimulation increases renal function in female, but not male, spontaneously hypertensive rats

Hilliard, L. M., Chow, C. L. E., Mirabito, K. M., Steckelings, U. M., Unger, T., Widdop, R. E. & Denton, K. M., 2014, In : Hypertension. 64, 2, p. 378 - 383 6 p.

Research output: Contribution to journalArticleResearchpeer-review

29 Citations (Scopus)

A novel agent with histone deacetylase inhibitory activity attenuates neointimal hyperplasia

Rahmatzadeh, M., Liu, H. B., Krishna, S. M., Gaspari, T. A., Spizzo, I., Widdop, R. E. & Dear, A. E., 2014, In : Cardiovascular Drugs and Therapy. 28, 5, p. 395 - 406 12 p.

Research output: Contribution to journalArticleResearchpeer-review

4 Citations (Scopus)

Antenatal antioxidant treatment with melatonin to decrease newborn neurodevelopmental deficits and brain injury caused by fetal growth restriction

Miller, S. L., Yawno, T., Alers, N. O., Zakhem, M. E., Supramaniam, V. G., van Zyl, N., Sabaretnam, T., Loose, J. M., Drummond, G. R., Walker, D. W., Jenkin, G. & Wallace, E. M., 2014, In : Journal of Pineal Research. 56, 3, p. 283 - 294 12 p.

Research output: Contribution to journalArticleResearchpeer-review

76 Citations (Scopus)

Antibodies in the pathogenesis of hypertension

Chan, C., Lieu, M., Toh, B-H., Kyaw, T. S., Bobik, A., Sobey, C. G. & Drummond, G. R., 2014, In : BioMed Research International. 2014, (Art. No: 504045), p. 1 - 9 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
16 Citations (Scopus)

A nuclear transport inhibitor that modulates the unfolded protein response and provides in vivo protection against lethal dengue virus infection

Fraser, J. E., Watanabe, S., Wang, C., Chan, W. K. K., Maher, B., Lopez-Denman, A., Hick, C. A., Wagstaff, K. M., Mackenzie, J. M., Sexton, P. M., Vasudevan, S. G. & Jans, D. A., 2014, In : Journal of Infectious Diseases. 210, 11, p. 1780 - 1791 12 p.

Research output: Contribution to journalArticleResearchpeer-review

51 Citations (Scopus)