Research Output 1986 2019

2015

Transient receptor potential vanilloid 4 inhibits mouse colonic motility by activating NO-dependent enteric neurotransmission

Fichna, J., Poole, D. P., Veldhuis, N., MacEachern, S. J., Saur, D., Zakrzewski, P. K., Cygankiewicz, A. I., Mokrowiecka, A., Malecka-Panas, E., Krajewska, W. M., Liedtke, W., Steinhoff, M. S., Timmermans, J-P., Bunnett, N. W., Sharkey, K. A. & Storr, M. A., 2015, In : Journal of Molecular Medicine. 93, 12, p. 1297-1309 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Venoms-Based Drug Discovery: Bioassays, Electrophysiology, High-Throughput Screens and Target Identification

Vetter, I., Hodgson, W. C., Adams, D. J. & McIntyre, P., 2015, Venoms to Drugs : Venom as a Source for the Development of Human Therapeutics. King, G. F. (ed.). 1st ed. UK: The Royal Society of Chemistry, p. 97 - 128 32 p.

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Otherpeer-review

What gastroenterologists should know about testing patients with eosinophilic esophagitis for food allergies

Philpott, H., Royce, S. G., Thien, F. C. K., Nandurkar, S. & Gibson, P. R., 2015, In : Clinical Gastroenterology and Hepatology. 13, 5, p. 1029 - 1030 2 p.

Research output: Contribution to journalLetterOtherpeer-review

β2-adrenoceptor signaling regulates invadopodia formation to enhance tumor cell invasion

Creed, S. J., Le, C. P., Hassan, M., Pon, C. K., Albold, S., Chan, K. T., Berginski, M. E., Huang, Z., Bear, J. E., Lane, J. R., Halls, M. L., Ferrari, D., Nowell, C. J. & Sloan, E. K., 2015, In : Breast Cancer Research. 17, 1, 12 p., 145.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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2014

Actions of rilmenidine on neurogenic hypertension in BPH/2J genetically hypertensive mice

Jackson, K. L., Palma-Rigo, K., Nguyen-Huu, T-P. & Head, G. A., 2014, In : Journal of Hypertension. 32, 3, p. 575 - 586 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Activation of mu opioid receptors sensitizes Transient Receptor Potential Vanilloid Type 1 (TRPV1) via beta-arrestin-2-mediated cross-talk

Rowan, M. P., Bierbower, S. M., Eskander, M. A., Szteyn, K., Por, E. D., Gomez, R., Veldhuis, N. A., Bunnett, N. W. & Jeske, N. A., 2014, In : PLoS ONE. 9, 4, 12 p., e93688.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Advances in G protein-coupled receptor allostery: From function to structure

Christopoulos, A., 2014, In : Molecular Pharmacology. 86, 5, p. 463 - 478 16 p.

Research output: Contribution to journalArticleResearchpeer-review

Allosteric interactions at adenosine A1 and A3 receptors: New insights into the role of small molecules and receptor dimerization

Hill, S. J., May, L. T., Kellam, B. & Woolard, J., 2014, In : British Journal of Pharmacology. 171, 5, p. 1102 - 1113 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Allosteric modulation of M1 muscarinic acetylcholine receptor internalization and subcellular trafficking

Yeatman, H. R., Lane, J. R. D., Choy, K. H. C., Lambert, N., Sexton, P., Christopoulos, A. & Canals, M., 2014, In : Journal of Biological Chemistry. 289, 22, p. 15856 - 15866 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Allosteric targeting of receptor tyrosine kinases

De Smet, F., Christopoulos, A. & Carmeliet, P., 2014, In : Nature Biotechnology. 32, 11, p. 1113 - 1120 8 p.

Research output: Contribution to journalArticleResearchpeer-review

A new mechanism of allostery in a G protein-coupled receptor dimer

Lane, J. R. D., Donthamsetti, P., Shonberg, J., Draper-Joyce, C. J., Dentry, S., Michino, M., Shi, L., Lopez Munoz, L., Scammells, P. J., Capuano, B., Sexton, P., Javitch, J. A. & Christopoulos, A., 2014, In : Nature Chemical Biology. 10, 9, p. 745 - 752 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Angiotensin (1-7) as a Therapy to Prevent Rupture of Intracranial Aneurysms?

Kuruppu, D. M. S., Smith, A. I., Drummond, G. R. & Sobey, C. G., 2014, In : Hypertension. 64, 2, p. 222 - 223 2 p.

Research output: Contribution to journalLetterOther

Angiotensin-converting enzyme 2 mediates hyperfiltration associated with diabetes

Tikellis, C., Brown, R., Head, G. A., Cooper, M. E. & Thomas, M. C., 1 Apr 2014, In : American Journal of Physiology - Renal Physiology. 306, 7, p. F773 - F780 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Angiotensin type 2 receptor stimulation increases renal function in female, but not male, spontaneously hypertensive rats

Hilliard, L. M., Chow, C. L. E., Mirabito, K. M., Steckelings, U. M., Unger, T., Widdop, R. E. & Denton, K. M., 2014, In : Hypertension. 64, 2, p. 378 - 383 6 p.

Research output: Contribution to journalArticleResearchpeer-review

A novel agent with histone deacetylase inhibitory activity attenuates neointimal hyperplasia

Rahmatzadeh, M., Liu, H. B., Krishna, S. M., Gaspari, T. A., Spizzo, I., Widdop, R. E. & Dear, A. E., 2014, In : Cardiovascular Drugs and Therapy. 28, 5, p. 395 - 406 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Antenatal antioxidant treatment with melatonin to decrease newborn neurodevelopmental deficits and brain injury caused by fetal growth restriction

Miller, S. L., Yawno, T., Alers, N. O., Zakhem, M. E., Supramaniam, V. G., van Zyl, N., Sabaretnam, T., Loose, J. M., Drummond, G. R., Walker, D. W., Jenkin, G. & Wallace, E. M., 2014, In : Journal of Pineal Research. 56, 3, p. 283 - 294 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Antibodies in the pathogenesis of hypertension

Chan, C., Lieu, M., Toh, B-H., Kyaw, T. S., Bobik, A., Sobey, C. G. & Drummond, G. R., 2014, In : BioMed Research International. 2014, (Art. No: 504045), p. 1 - 9 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

A nuclear transport inhibitor that modulates the unfolded protein response and provides in vivo protection against lethal dengue virus infection

Fraser, J. E., Watanabe, S., Wang, C., Chan, W. K. K., Maher, B., Lopez-Denman, A., Hick, C. A., Wagstaff, K. M., Mackenzie, J. M., Sexton, P. M., Vasudevan, S. G. & Jans, D. A., 2014, In : Journal of Infectious Diseases. 210, 11, p. 1780 - 1791 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Biased agonism at G protein-coupled receptors: The promise and the challenges - A medicinal chemistry perspective

Shonberg, J., Lopez Munoz, L., Scammells, P. J., Christopoulos, A., Capuano, B. & Lane, J. R. D., 2014, In : Medicinal Research Reviews. 34, 6, p. 1286 - 1330 45 p.

Research output: Contribution to journalArticleResearchpeer-review

Brain immune cell composition and functional outcome after cerebral ischemia: comparison of two mouse strains

Kim, H. A., Whittle, S., Lee, S. S., Chu, H., Zhang, S., Wei, Z., Arumugam, T., Vinh, A., Drummond, G. R. & Sobey, C. G., 2014, In : Frontiers in Cellular Neuroscience. 8, 365, 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Cathepsin S causes inflammatory pain via biased agonism of PAR2 and TRPV4

Zhao, P., Lieu, T. M., Barlow, N., Metcalf, M., Veldhuis, N. A., Jensen, D. D., Kocan, M., Sostegni, S., Haerteis, S., Baraznenok, V. A., Henderson, I., Lindstrom, E., Guerrero-Alba, R., Valdez-Morales, E., Liedtke, W., McIntyre, P., Vanner, S., Korbmacher, C. & Bunnett, N. W., 2014, In : Journal of Biological Chemistry. 289, 39, p. 27215 - 27234 20 p.

Research output: Contribution to journalArticleResearchpeer-review

Characterization of a novel model incorporating airway epithelial damage and related fibrosis to the pathogenesis of asthma

Royce, S. G., Patel, K. P. & Samuel, C. S., 2014, In : Laboratory Investigation. 94, 12, p. 1326 - 1339 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Characterization of the novel positive allosteric modulator, LY2119620, at the muscarinic M(2) and M(4) receptors

Croy, C. H., Schober, D. A., Xiao, H., Quets, A., Christopoulos, A. & Felder, C. C., 2014, In : Molecular Pharmacology. 86, 1, p. 106 - 115 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Chironex fleckeri (box jellyfish) venom proteins: expansion of a cnidarian toxin family that elicits variable cytolytic and cardiovascular effects

Brinkman, D. L., Konstantakopoulos, N., McInerney, B., Mulvenna, J., Seymour, J. E., Isbister, G. K. & Hodgson, W. C., 2014, In : Journal of Biological Chemistry. 289, 8, p. 4798 - 4812 15 p.

Research output: Contribution to journalArticleResearchpeer-review

Chronic aldosterone administration causes Nox2-mediated increases in reactive oxygen species production and endothelial dysfunction in the cerebral circulation

Chrissobolis, S., Drummond, G. R., Faraci, F. M. & Sobey, C. G., 2014, In : Journal of Hypertension. 32, 9, p. 1815 - 1821 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Comparative studies of the venom of a new Taipan species, Oxyuranus temporalis, with other members of its genus

Barber, C. M., Madaras, F., Turnbull, R. K., Morley, T., Dunstan, N., Allen, L., Kuchel, T., Mirtschin, P. & Hodgson, W. C., 2014, In : Toxins. 6, 7, p. 1979 - 1995 17 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Correction to Septic shock: Desperately seeking treatment [Clinical Science, 126 (2014), 31-39]

Huet, O. & Chin-Dusting, J. P. F., Mar 2014, In : Clinical Science. 126, 6, p. 459 1 p.

Research output: Contribution to journalComment / DebateOtherpeer-review

DC isoketal-modified proteins activate T cells and promote hypertension

Kirabo, A., Fontana, V., de Faria, A. P. C., Loperena, R., Galindo, C. L., Wu, J., Bikineyeva, A. T., Dikalov, S., Xiao, L., Chen, W., Saleh, M. A., Trott, D. W., Itani, H. A., Vinh, A., Amarnath, V., Amarnath, K., Guzik, T. J., Bernstein, K. E., Shen, X. G. Z., Shyr, Y. & 9 othersChen, S-C., Mernaugh, R. L., Laffer, C. L., Elijovich, F., Davies, S. S., Moreno, H., Madhur, M. S., Roberts II, L. J. & Harrison, D. G., 2014, In : Journal of Clinical Investigation. 124, 10, p. 4642 - 4656 15 p.

Research output: Contribution to journalArticleResearchpeer-review

Development of a photoactivatable allosteric ligand for the M1 muscarinic acetylcholine receptor

Davie, B. J., Sexton, P., Capuano, B., Christopoulos, A. & Scammells, P. J., 2014, In : ACS Chemical Neuroscience. 5, 10, p. 902 - 907 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Development of a radioligand, [(3)H]LY2119620, to probe the human M(2) and M(4) muscarinic receptor allosteric binding sites

Schober, D. A., Croy, C. H., Xiao, H., Christopoulos, A. & Felder, C. C., 2014, In : Molecular Pharmacology. 86, 1, p. 116 - 123 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Differential phenotypes of tissue-infiltrating T cells during angiotensin II-induced hypertension in mice

Wei, Z., Spizzo, I., Diep, H., Drummond, G. R., Widdop, R. E. & Vinh, A., 2014, In : PLoS ONE. 9, 12, 21 p., e114895.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Direct angiotensin AT2 receptor stimulation using a novel AT2 receptor agonist, compound 21, evokes neuroprotection in conscious hypertensive rats

McCarthy, C. A., Vinh, A., Miller, A. A., Hallberg, A., Alterman, M., Callaway, J. K. & Widdop, R. E., 2014, In : PLoS ONE. 9, 4 (Art. No: e95762), p. 1 - 10 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Electronic sculpting of ligand-GPCR subtype selectivity: the case of angiotensin II

Magnani, F., Pappas, C. G., Crook, T., Magafa, V., Cordopatis, P. A., Ishiguro, S., Ohta, N., Selent, J., Bosnyak, S., Jones, E. S., Gerothanassis, I. P., Tamura, M., Widdop, R. E. & Tzakos, A. G., 2014, In : ACS Chemical Biology. 9, 7, p. 1420 - 1425 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Endothelial cell mineralocorticoid receptors regulate deoxycorticosterone/salt-mediated cardiac remodeling and vascular reactivity but not blood pressure

Rickard, A., Morgan, J., Chrissobolis, S., Miller, A. A., Sobey, C. G. & Young, M. J., 2014, In : Hypertension. 63, 5, p. 1033 - 1040 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Endothelial NADPH oxidases: which NOX to target in vascular disease?

Drummond, G. R. & Sobey, C. G., 2014, In : Trends in Endocrinology and Metabolism. 25, 9, p. 452 - 463 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Endothelin-converting enzyme 1 and beta-arrestins exert spatiotemporal control of substance P-induced inflammatory signals

Jensen, D. D., Halls, M. L., Murphy, J. E., Canals, M., Cattaruzza, F., Poole, D. P., Lieu, T. M., Koon, H-W., Pothoulakis, C. & Bunnett, N. W., 2014, In : Journal of Biological Chemistry. 289, 29, p. 20283 - 20294 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Energy metabolism in BPH/2J genetically hypertensive mice

Jackson, K. L., Nguyen-Huu, T-P., Davern, P. J. & Head, G. A., 2014, In : Hypertension Research. 37, 5, p. 413 - 421 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Engendering biased signalling from the calcium-sensing receptor for the pharmacotherapy of diverse disorders

Leach, K., Sexton, P., Christopoulos, A. & Conigrave, A., 2014, In : British Journal of Pharmacology. 171, 5, p. 1142 - 1155 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Evidence that collaboration between HIF-1a and Notch-1 promotes neuronal cell death in ischemic stroke

Cheng, Y-L., Park, J-S., Manzanero, S., Choi, Y., Baik, S-H., Okun, E., Gelderblom, M., Fann, D. Y-W., Magnus, T., Launikonis, B. S., Mattson, M. P., Sobey, C. G., Jo, D-G. & Arumugam, T., 2014, In : Neurobiology of Disease. 62, p. 286 - 295 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Evidence that neuronal Notch-1 promotes JNK/c-Jun activation and cell death following ischemic stress

Cheng, Y-L., Choi, Y., Seow, W. L., Manzanero, S., Sobey, C. G., Jo, D-G. & Arumugam, T. V., 2014, In : Brain Research. 1586, p. 193 - 202 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Exposure to a high-fat diet during development alters leptin and ghrelin sensitivity and elevates renal sympathetic nerve activity and arterial pressure in rabbits

Prior, L. J., Davern, P. J., Burke, S. L., Lim, K., Armitage, J. A. & Head, G. A., 2014, In : Hypertension. 63, 2, p. 338 - 345 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Feeding-dependent activation of enteric cells and sensory neurons by lymphatic fluid: Evidence for a neurolymphocrine system

Poole, D. P., Lee, M., Tso, P., Bunnett, N. W., Yo, S. J., Lieu, T. M., Shiu, A., Wang, J-C., Nomura, D. & Aponte, G. W., 2014, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 306, 8, p. G686 - G698 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Functional and structural perspectives on allosteric modulation of GPCRs

Langmead, C. J. & Christopoulos, A., 2014, In : Current Opinion in Cell Biology. 27, 1, p. 94 - 101 8 p.

Research output: Contribution to journalArticleResearchpeer-review

GABAA receptor dysfunction contributes to high blood pressure and exaggerated response to stress in Schlager genetically hypertensive mice

Davern, P. J., Chowdhury, S., Jackson, K. L., Nguyen-Huu, T-P. & Head, G. A., 2014, In : Journal of Hypertension. 32, 2, p. 352 - 362 11 p.

Research output: Contribution to journalArticleResearchpeer-review

GPBA: A GPCR for bile acids and an emerging therapeutic target for disorders of digestion and sensation

Lieu, T. M., Jayaweera, G. & Bunnett, N. W., 2014, In : British Journal of Pharmacology. 171, 5, p. 1156 - 1166 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Human mesenchymal stem cells alter macrophage phenotype and promote regeneration via homing to the kidney following ischemia-reperfusion injury

Wise, A. F., Williams, T. M., Kiewiet, M. B. G., Payne, N. L., Siatskas, C., Samuel, C. S. & Ricardo, S. D., 2014, In : American Journal of Physiology - Renal Physiology. 306, 10, p. 1222 - 1235 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Hydrogen sulfide protects endothelial nitric oxide function under conditions of acute oxidative stress in vitro

Al-Magableh, M. R., Harper, B. K., Ng, H. H., Miller, A. A. & Hart, J., 2014, In : Naunyn-Schmiedeberg's Archives of Pharmacology. 387, 1, p. 67 - 74 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Hypotensive and vascular relaxant effects of phospholipase A2 toxins from Papuan taipan (Oxyuranus scutellatus) venom

Chaisakul, J., Isbister, G. K., Tare, M., Parkington, H. C. & Hodgson, W. C., 2014, In : European Journal of Pharmacology. 723, 1, p. 227 - 233 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Identification of genes with altered expression in male and female Schlager hypertensive mice

Chiu, C., Jackson, K. E., Hearn, N. L., Steiner, N., Head, G. A. & Lind, J. M., 2014, In : BMC Medical Genetics. 15, 1 9Art. No.: 101), p. 1 - 6 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Identification of overlapping but differential binding sites for the high-affinity CXCR3 antagonists NBI-74330 and VUF11211

Scholten, D. J., Roumen, L., Wijtmans, M., Verkade-Vreeker, M. C. A., Custers, H., Lai, M., de Hooge, D., Canals, M., de Esch, I. J. P., Smit, M. J., de Graaf, C. & Leurs, R., Jan 2014, In : Molecular Pharmacology. 85, 1, p. 116-126 11 p.

Research output: Contribution to journalArticleResearchpeer-review