Research Output 1986 2019

2014

Development of a radioligand, [(3)H]LY2119620, to probe the human M(2) and M(4) muscarinic receptor allosteric binding sites

Schober, D. A., Croy, C. H., Xiao, H., Christopoulos, A. & Felder, C. C., 2014, In : Molecular Pharmacology. 86, 1, p. 116 - 123 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Differential phenotypes of tissue-infiltrating T cells during angiotensin II-induced hypertension in mice

Wei, Z., Spizzo, I., Diep, H., Drummond, G. R., Widdop, R. E. & Vinh, A., 2014, In : PLoS ONE. 9, 12, 21 p., e114895.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Direct angiotensin AT2 receptor stimulation using a novel AT2 receptor agonist, compound 21, evokes neuroprotection in conscious hypertensive rats

McCarthy, C. A., Vinh, A., Miller, A. A., Hallberg, A., Alterman, M., Callaway, J. K. & Widdop, R. E., 2014, In : PLoS ONE. 9, 4 (Art. No: e95762), p. 1 - 10 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Electronic sculpting of ligand-GPCR subtype selectivity: the case of angiotensin II

Magnani, F., Pappas, C. G., Crook, T., Magafa, V., Cordopatis, P. A., Ishiguro, S., Ohta, N., Selent, J., Bosnyak, S., Jones, E. S., Gerothanassis, I. P., Tamura, M., Widdop, R. E. & Tzakos, A. G., 2014, In : ACS Chemical Biology. 9, 7, p. 1420 - 1425 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Endothelial cell mineralocorticoid receptors regulate deoxycorticosterone/salt-mediated cardiac remodeling and vascular reactivity but not blood pressure

Rickard, A., Morgan, J., Chrissobolis, S., Miller, A. A., Sobey, C. G. & Young, M. J., 2014, In : Hypertension. 63, 5, p. 1033 - 1040 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Endothelial NADPH oxidases: which NOX to target in vascular disease?

Drummond, G. R. & Sobey, C. G., 2014, In : Trends in Endocrinology and Metabolism. 25, 9, p. 452 - 463 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Endothelin-converting enzyme 1 and beta-arrestins exert spatiotemporal control of substance P-induced inflammatory signals

Jensen, D. D., Halls, M. L., Murphy, J. E., Canals, M., Cattaruzza, F., Poole, D. P., Lieu, T. M., Koon, H-W., Pothoulakis, C. & Bunnett, N. W., 2014, In : Journal of Biological Chemistry. 289, 29, p. 20283 - 20294 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Energy metabolism in BPH/2J genetically hypertensive mice

Jackson, K. L., Nguyen-Huu, T-P., Davern, P. J. & Head, G. A., 2014, In : Hypertension Research. 37, 5, p. 413 - 421 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Engendering biased signalling from the calcium-sensing receptor for the pharmacotherapy of diverse disorders

Leach, K., Sexton, P., Christopoulos, A. & Conigrave, A., 2014, In : British Journal of Pharmacology. 171, 5, p. 1142 - 1155 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Evidence that collaboration between HIF-1a and Notch-1 promotes neuronal cell death in ischemic stroke

Cheng, Y-L., Park, J-S., Manzanero, S., Choi, Y., Baik, S-H., Okun, E., Gelderblom, M., Fann, D. Y-W., Magnus, T., Launikonis, B. S., Mattson, M. P., Sobey, C. G., Jo, D-G. & Arumugam, T., 2014, In : Neurobiology of Disease. 62, p. 286 - 295 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Evidence that neuronal Notch-1 promotes JNK/c-Jun activation and cell death following ischemic stress

Cheng, Y-L., Choi, Y., Seow, W. L., Manzanero, S., Sobey, C. G., Jo, D-G. & Arumugam, T. V., 2014, In : Brain Research. 1586, p. 193 - 202 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Exposure to a high-fat diet during development alters leptin and ghrelin sensitivity and elevates renal sympathetic nerve activity and arterial pressure in rabbits

Prior, L. J., Davern, P. J., Burke, S. L., Lim, K., Armitage, J. A. & Head, G. A., 2014, In : Hypertension. 63, 2, p. 338 - 345 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Feeding-dependent activation of enteric cells and sensory neurons by lymphatic fluid: Evidence for a neurolymphocrine system

Poole, D. P., Lee, M., Tso, P., Bunnett, N. W., Yo, S. J., Lieu, T. M., Shiu, A., Wang, J-C., Nomura, D. & Aponte, G. W., 2014, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 306, 8, p. G686 - G698 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Functional and structural perspectives on allosteric modulation of GPCRs

Langmead, C. J. & Christopoulos, A., 2014, In : Current Opinion in Cell Biology. 27, 1, p. 94 - 101 8 p.

Research output: Contribution to journalArticleResearchpeer-review

GABAA receptor dysfunction contributes to high blood pressure and exaggerated response to stress in Schlager genetically hypertensive mice

Davern, P. J., Chowdhury, S., Jackson, K. L., Nguyen-Huu, T-P. & Head, G. A., 2014, In : Journal of hypertension. 32, 2, p. 352 - 362 11 p.

Research output: Contribution to journalArticleResearchpeer-review

GPBA: A GPCR for bile acids and an emerging therapeutic target for disorders of digestion and sensation

Lieu, T. M., Jayaweera, G. & Bunnett, N. W., 2014, In : British Journal of Pharmacology. 171, 5, p. 1156 - 1166 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Human mesenchymal stem cells alter macrophage phenotype and promote regeneration via homing to the kidney following ischemia-reperfusion injury

Wise, A. F., Williams, T. M., Kiewiet, M. B. G., Payne, N. L., Siatskas, C., Samuel, C. S. & Ricardo, S. D., 2014, In : American Journal of Physiology - Renal Physiology. 306, 10, p. 1222 - 1235 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Hydrogen sulfide protects endothelial nitric oxide function under conditions of acute oxidative stress in vitro

Al-Magableh, M. R., Harper, B. K., Ng, H. H., Miller, A. A. & Hart, J., 2014, In : Naunyn-Schmiedeberg's Archives of Pharmacology. 387, 1, p. 67 - 74 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Hypotensive and vascular relaxant effects of phospholipase A2 toxins from Papuan taipan (Oxyuranus scutellatus) venom

Chaisakul, J., Isbister, G. K., Tare, M., Parkington, H. C. & Hodgson, W. C., 2014, In : European Journal of Pharmacology. 723, 1, p. 227 - 233 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Identification of genes with altered expression in male and female Schlager hypertensive mice

Chiu, C., Jackson, K. E., Hearn, N. L., Steiner, N., Head, G. A. & Lind, J. M., 2014, In : BMC Medical Genetics. 15, 1 9Art. No.: 101), p. 1 - 6 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Identification of overlapping but differential binding sites for the high-affinity CXCR3 antagonists NBI-74330 and VUF11211

Scholten, D. J., Roumen, L., Wijtmans, M., Verkade-Vreeker, M. C. A., Custers, H., Lai, M., de Hooge, D., Canals, M., de Esch, I. J. P., Smit, M. J., de Graaf, C. & Leurs, R., Jan 2014, In : Molecular Pharmacology. 85, 1, p. 116-126 11 p.

Research output: Contribution to journalArticleResearchpeer-review

IL-1beta and IL-18: inflammatory markers or mediators of hypertension?

Murali Krishnan, S., Sobey, C. G., Latz, E., Mansell, A. S. & Drummond, G. R., 2014, In : British Journal of Pharmacology. 171, 24, p. 5589 - 5602 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Immune cell infiltration in malignant middle cerebral artery infarction: comparison with transient cerebral ischemia

Chu, H. X., Huynh, K., Lee, S. S., Moore, J. P., Chan, C. T. L., Vinh, A., Gelderblom, M., Arumugam, T., Broughton, B. R. S., Drummond, G. R. & Sobey, C. G., 2014, In : Journal of Cerebral Blood Flow and Metabolism. 34, 3, p. 450 - 459 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Immune mechanisms in vascular disease and stroke

Toh, B-H., Bobik, A., Kyaw, T. S., Drummond, G. R., Sobey, C. G. & Guzik, T. J., 2014, In : BioMed Research International. 2014, p. e730691 - e730691 3 p.

Research output: Contribution to journalLetterOther

Improving type 2 diabetes through a distinct adrenergic signaling pathway involving mTORC2 that mediates glucose uptake in skeletal muscle

Sato, M., Dehvari, N., Oberg, A., Dallner, O. S., Sandstrom, A. L., Olsen, J. M., Csikasz, R. I., Summers, R. J., Hutchinson, D. S. & Bengtsson, T., 2014, In : Diabetes. 63, 12, p. 4115 - 4129 15 p.

Research output: Contribution to journalArticleResearchpeer-review

Influenza A virus and TLR7 activation potentiate NOX2 oxidase-dependent ROS production in macrophages

To, E., Broughton, B. R. S., Hendricks, K. S., Vlahos, R. & Selemidis, S., 2014, In : Free Radical Research. 48, 8, p. 940 - 947 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Inhibition of presynaptic neurotoxins in taipan venom by suramin

Kuruppu, D. M. S., Chaisakul, J., Smith, A. I. & Hodgson, W. C., 2014, In : Neurotoxicity Research. 25, 3, p. 305 - 310 6 p.

Research output: Contribution to journalArticleResearchpeer-review

International union of basic and clinical pharmacology. XC. Multisite pharmacology: Recommendations for the nomenclature of receptor allosterism and allosteric ligands

Christopoulos, A., Changeux, J-P., Catterall, W. A., Fabbro, D., Burris, T. P., Cidlowski, J. A., Olsen, R. W., Peters, J. A., Neubig, R., Pin, J. P., Sexton, P., Kenakin, T. P., Ehlert, F. J., Spedding, M. & Langmead, C. J., 2014, In : Pharmacological Reviews. 66, 4, p. 918 - 947 30 p.

Research output: Contribution to journalArticleResearchpeer-review

Intranasally administered serelaxin abrogates airway remodelling and attenuates airway hyperresponsiveness in allergic airways disease

Royce, S. G., Lim, C., Patel, K. P., Wang, B., Samuel, C. S. & Tang, M. L. K., 2014, In : Clinical and Experimental Allergy. 44, 11, p. 1399 - 1408 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Intravenous immunoglobulin (IVIg) provides protection against endothelial cell dysfunction and death in ischemic stroke

Widiapradja, A., Santro, T., Basta, M., Sobey, C. G., Manzanero, S. & Arumugam, T., 2014, In : Experimental & Translational Stroke Medicine. 6, 1 (Art. No.: 7), p. 1 - 6 6 p.

Research output: Contribution to journalArticleResearchpeer-review

In-vitro neurotoxicity of two Malaysian krait species (Bungarus candidus and Bungarus fasciatus) venoms: neutralization by monovalent and polyvalent antivenoms from Thailand

Ahmad Rusmili, M. R., Tee, T. Y., Mustafa, M. R., Othman, I. & Hodgson, W. C., 2014, In : Toxins. 6, 3, p. 1036 - 1048 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

In vitro toxic effects of puff adder (Bitis arietans) venom, and their neutralization by antivenom

Fernandez, S., Hodgson, W. C., Chaisakul, J., Kornhauser, R. S., Konstantakopoulos, N., Smith, A. I. & Kuruppu, D. M. S., 2014, In : Toxins. 6, 5, p. 1586 - 1597 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Isolation and characterization of alpha-elapitoxin-Bf1b, a postsynaptic neurotoxin from Malaysian Bungarus fasciatus venom

Ahmad Rusmili, M. R., Tee, T. Y., Mustafa, M. R., Othman, I. & Hodgson, W. C., 2014, In : Biochemical Pharmacology. 88, 2, p. 229 - 236 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Isolation and characterization of a presynaptic neurotoxin, P-elapitoxin-Bf1a from Malaysian Bungarus fasciatus venom

Ahmad Rusmili, M. R., Tee, T. Y., Mustafa, M. R., Hodgson, W. C. & Othman, I., 2014, In : Biochemical Pharmacology. 91, 3, p. 409 - 416 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Localisation and activation of the neurokinin 1 receptor in the enteric nervous system of the mouse distal colon

Pelayo, J-C., Veldhuis, N. A., Eriksson, E. M., Bunnett, N. W. & Poole, D. P., 2014, In : Cell and Tissue Research. 356, 2, p. 319 - 332 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Localization of receptors for calcitonin-gene-related peptide to intraganglionic laminar endings of the mouse esophagus: Peripheral interaction between vagal and spinal afferents?

Horling, L., Bunnett, N. W., Messlinger, K., Neuhuber, W. L. & Raab, M., 2014, In : Histochemistry and Cell Biology. 141, 3, p. 321 - 335 15 p.

Research output: Contribution to journalArticleResearchpeer-review

Low-dose maternal alcohol consumption: effects in the hearts of offspring in early life and adulthood

Nguyen, V. B., Probyn, M. E., Campbell, F., Yin, K. V., Samuel, C. S., Zimanyi, M. A., Bertram, J. F., Black, M. J. & Moritz, K. M., 2014, In : Physiological Reports. 2, 7, p. 1 - 12 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Major contribution of the medial amygdala to hypertension in BPH/2J genetically hypertensive mice

Jackson, K. L., Palma-Rigo, K., Nguyen-Huu, T-P., Davern, P. J. & Head, G. A., 2014, In : Hypertension. 63, 4, p. 811 - 818 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Mechanistic insights into allosteric structure-function relationships at the M1 muscarinic acetylcholine receptor

Abdul Ridha, A., Lane, J. R. D., Mistry, S. N., Lopez Munoz, L., Sexton, P., Scammells, P. J., Christopoulos, A. & Canals, M., 2014, In : Journal of Biological Chemistry. 289, 48, p. 33701 - 33711 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Mechanistic insights into the contribution of epithelial damage to airway remodeling. Novel therapeutic targets for asthma

Royce, S. G., Li, X., Tortorella, S., Goodings, L. M., Chow, B. SM., Giraud, A. S., Tang, M. L. K. & Samuel, C. S., 2014, In : American Journal of Respiratory Cell and Molecular Biology. 50, 1, p. 180 - 192 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Molecular determinants of allosteric modulation at the M1 muscarinic acetylcholine receptor

Abdul Ridha, A., Lopez, L., Keov, P., Thal, D., Mistry, S. N., Sexton, P., Lane, J. R. D., Canals, M. & Christopoulos, A., 2014, In : Journal of Biological Chemistry. 289, 9, p. 6067 - 6079 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Molecular mechanisms of bitopic ligand engagement with the M1 muscarinic acetylcholine receptor

Keov, P., Lopez, L., Devine, S., Valant, C., Lane, J. R. D., Scammells, P. J., Sexton, P. & Christopoulos, A., 2014, In : Journal of Biological Chemistry. 289, 34, p. 23817 - 23837 21 p.

Research output: Contribution to journalArticleResearchpeer-review

Muscarinic acetylcholine receptors: Novel opportunities for drug development

Kruse, A. C., Kobilka, B., Gautam, D., Sexton, P. M., Christopoulos, A. & Wess, J., 2014, In : Nature Reviews Drug Discovery. 13, 7, p. 549 - 560 12 p.

Research output: Contribution to journalArticleResearchpeer-review

NADPH oxidases as novel pharmacologic targets against influenza A virus infection

Vlahos, R. & Selemidis, S., 2014, In : Molecular Pharmacology. 86, 6, p. 747 - 759 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Neural peptidase endothelin-converting enzyme 1 regulates endothelin 1-induced pruritus

Kido-Nakahara, M., Buddenkotte, J., Kempkes, C., Ikoma, A., Cevikbas, F., Akiyama, T., Nunes, F., Seeliger, S., Hasdemir, B., Mess, C., Buhl, T., Sulk, M., Muller, F-U., Metze, D., Bunnett, N. W., Bhargava, A., Carstens, E., Furue, M. & Steinhoff, M. S., 2014, In : Journal of Clinical Investigation. 124, 6, p. 2683 - 2695 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Neuro-humoral signalling by bile acids and the TGR5 receptor in the gastrointestinal tract

Bunnett, N. W., 2014, In : The Journal of Physiology. 592, 14, p. 2943 - 2950 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Novel therapeutic strategies for lung disorders associated with airway remodelling and fibrosis

Royce, S. G., Moodley, Y. & Samuel, C. S., 2014, In : Pharmacology and Therapeutics. 141, 3, p. 250 - 260 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Pharmacokinetics and pharmacodynamics of the myotoxic venom of Pseudechis australis (mulga snake) in the anesthetised rat

Hart, A. J., Hodgson, W. C., O'Leary, M. A. & Isbister, G. K., 2014, In : Clinical Toxicology. 52, 6, p. 604 - 610 7 p.

Research output: Contribution to journalArticleResearchpeer-review

PI3Kdelta inhibition reduces TNF secretion and neuroinflammation in a mouse cerebral stroke model

Low, P. C., Manzanero, S., Mohannak, N., Narayana, V. K., Nguyen, T. H., Kvaskoff, D., Brennan, F. H., Ruitenberg, M. J., Gelderblom, M., Magnus, T., Kim, H. H. A., Broughton, B. R. S., Sobey, C. G., Vanhaesebroeck, B., Stow, J. L., Arumugam, T. & Meunier, F. A., 2014, In : Nature Communications. 5, 3450, p. 1 - 12 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Potential efficacy of amnion epithelial cells to treat post-stroke inflammation

Broughton, B. R. S., Lim, R. S. W., Evans, M. A., Drummond, G. R., Wallace, E. M. & Sobey, C. G., 2014, Perinatal Stem Cells. Atala, A. & Murphy, S. V. (eds.). 1st ed. USA: Springer, p. 219 - 229 11 p.

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Researchpeer-review