Research Output 1986 2019

2015

Receptor expression modulates calcium-sensing receptor mediated intracellular Ca2+ mobilization

Brennan, S. C., Mun, H., Leach, K., Kuchel, P. W., Christopoulos, A. & Conigrave, A., 2015, In : Endocrinology. 156, 4, p. 1330 - 1342 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Risk of major cardiovascular events in people with down syndrome

Sobey, C. G., Judkins, C. P., Sundararajan, V., Phan, T. G., Drummond, G. R. & Srikanth, V. K., 2015, In : PLoS ONE. 10, 9, 11 p., e0137093.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Rosiglitazone elicits in vitro relaxation in airways and precision cut lung slices from a mouse model of chronic allergic airways disease

Donovan, C., Bailey, S. R., Tran, J., Haitsma, G., Ibrahim, Z. A., Foster, S. R., Tang, M. L. K., Royce, S. G. & Bourke, J. E., 2015, In : American Journal of Physiology - Lung Cellular and Molecular Physiology. 309, 10, p. 1219 - 1228 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Seasonal recurrence of food bolus obstruction in eosinophilic esophagitis

Philpott, H., Nandurkar, S., Thien, F. C. K., Bloom, S. D., Lin, E., Goldberg, R., Boyapati, R., Finch, A., Royce, S. G. & Gibson, P. R., 2015, In : Internal Medicine Journal. 45, 9, p. 939 - 943 5 p.

Research output: Contribution to journalArticleResearchpeer-review

Sensitisation of TRPV4 by PAR2 is independent of intracellular calcium signalling and can be mediated by the biased agonist neutrophil elastase

Sostegni, S., Diakov, A., McIntyre, P., Bunnett, N., Korbmacher, C. & Haerteis, S., 2015, In : Pflugers Archiv-European Journal of Physiology. 467, 4, p. 687-701 15 p.

Research output: Contribution to journalArticleResearchpeer-review

Serelaxin-mediated signal transduction in human vascular cells: bell-shaped concentration-response curves reflect differential coupling to G proteins

Sarwar, M., Samuel, C. S., Bathgate, R. A., Stewart, D. R. & Summers, R. J., 2015, In : British Journal of Pharmacology. 172, 4, p. 1005-1019 15 p.

Research output: Contribution to journalArticleResearchpeer-review

Sex differences in AT2R expression and action

Hilliard, L. M., Mirabito, K. M., Widdop, R. E. & Denton, K. M., 2015, The Protective Arm of the Renin-Angiotensin System: Functional Aspects and Therapeutic Implications. Unger, T., Steckelings, U. M. & dos Santos, R. A. S. (eds.). 1st ed. London UK: Elsevier, p. 125 - 130 6 p.

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Researchpeer-review

Specific role of dietary fat in modifying cardiovascular and locomotor activity 24-h rhythms

Barzel, B., Lim, K. J., Burke, S. L., Armitage, J. A. & Head, G. A., 2015, In : Chronobiology International. 32, 5, p. 668 - 676 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Stonefish toxin defines an ancient branch of the perforin-like superfamily

Ellisdon, A. M., Reboul, C. F., Panjikar, S., Huynh, K., Oellig, C. A., Winter, K. L., Dunstone, M. A., Hodgson, W. C., Seymour, J. E., Dearden, P. K., Tweten, R. K., Whisstock, J. C. & McGowan, S., 2015, In : Proceedings of the National Academy of Sciences. 112, 50, p. 15360 - 15365 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Structural and functional correlations in a large animal model of bleomycin-induced pulmonary fibrosis

Organ, L., Bacci, B., Koumoundouros, E., Barcham, G. J., Milne, M., Kimpton, W. G., Samuel, C. S. & Snibson, K. J., 2015, In : BMC Pulmonary Medicine. 15, 1 , 15 p., 81.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Structural determinants for binding to angiotensin converting enzyme 2 (ACE2) and angiotensin receptors 1 and 2

Clayton, D. J., Hanchapola, I., Thomas, W. G., Widdop, R. E., Smith, A. I., Perlmutter, P. & Aguilar, M. M. I. . I., 2015, In : Frontiers in Pharmacology. 6, (Art. No: 5), p. 1 - 9 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Synthesis and pharmacological evaluation of M4 muscarinic receptor positive allosteric modulators derived from VU10004

Huynh, T., Valant, C., Crosby, I. T., Sexton, P., Christopoulos, A. & Capuano, B., 2015, In : ACS Chemical Neuroscience. 6, 6, p. 838 - 844 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Synthesis of six mexiletine derivatives with isoindolines attached as potential antioxidants and their evaluation as cardioprotective agents

Chau, B. A., Drummond, G. R., Jackson, W. R., Jarrott, B., Miller, A. A., Subasinghe, K. R., Tan, C. Y. R., White, P. J., Wright, C. E. & Ziogas, J., 2015, In : MedChemComm. 6, 4, p. 634-639 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Synthetic covalently linked dimeric form of H2 relaxin retains native RXFP1 activity and has improved in vitro serum stability

Nair, V. B., Bathgate, R. A. D., Separovic, F., Samuel, C. S., Hossain, M. A. & Wade, J. D., 2015, In : BioMed Research International. 2015, 10 p., 731852.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Targeting of transient receptor potential channels in digestive disease

Poole, D. P., Lieu, T., Veldhuis, N. A., Rajasekhar, P. & Bunnett, N. W., 2015, TRP Channels as Therapeutic Targets: From Basic Science to Clinical Use. Szallasi, A. (ed.). London UK: Elsevier, p. 385-403 19 p.

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Researchpeer-review

The G protein-coupled receptor-transient receptor potential channel axis: molecular insights for targeting disorders of sensation and inflammation

Veldhuis, N. A., Poole, D. P., Grace, M., McIntyre, P. & Bunnett, N. W., 2015, In : Pharmacological Reviews. 67, 1, p. 36 - 73 38 p.

Research output: Contribution to journalArticleResearchpeer-review

Towards tissue-specific pharmacology: insights from the calcium-sensing receptor as a paradigm for GPCR (patho)physiological bias

Leach, K., Conigrave, A. D., Sexton, P. M. & Christopoulos, A., 2015, In : Trends in Pharmacological Sciences. 36, 4, p. 215-225 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Transient receptor potential vanilloid 4 inhibits mouse colonic motility by activating NO-dependent enteric neurotransmission

Fichna, J., Poole, D. P., Veldhuis, N., MacEachern, S. J., Saur, D., Zakrzewski, P. K., Cygankiewicz, A. I., Mokrowiecka, A., Malecka-Panas, E., Krajewska, W. M., Liedtke, W., Steinhoff, M. S., Timmermans, J-P., Bunnett, N. W., Sharkey, K. A. & Storr, M. A., 2015, In : Journal of Molecular Medicine. 93, 12, p. 1297-1309 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Venoms-Based Drug Discovery: Bioassays, Electrophysiology, High-Throughput Screens and Target Identification

Vetter, I., Hodgson, W. C., Adams, D. J. & McIntyre, P., 2015, Venoms to Drugs : Venom as a Source for the Development of Human Therapeutics. King, G. F. (ed.). 1st ed. UK: The Royal Society of Chemistry, p. 97 - 128 32 p.

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Otherpeer-review

What gastroenterologists should know about testing patients with eosinophilic esophagitis for food allergies

Philpott, H., Royce, S. G., Thien, F. C. K., Nandurkar, S. & Gibson, P. R., 2015, In : Clinical Gastroenterology and Hepatology. 13, 5, p. 1029 - 1030 2 p.

Research output: Contribution to journalLetterOtherpeer-review

β2-adrenoceptor signaling regulates invadopodia formation to enhance tumor cell invasion

Creed, S. J., Le, C. P., Hassan, M., Pon, C. K., Albold, S., Chan, K. T., Berginski, M. E., Huang, Z., Bear, J. E., Lane, J. R., Halls, M. L., Ferrari, D., Nowell, C. J. & Sloan, E. K., 2015, In : Breast Cancer Research. 17, 1, 12 p., 145.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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2014

Actions of rilmenidine on neurogenic hypertension in BPH/2J genetically hypertensive mice

Jackson, K. L., Palma-Rigo, K., Nguyen-Huu, T-P. & Head, G. A., 2014, In : Journal of hypertension. 32, 3, p. 575 - 586 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Activation of mu opioid receptors sensitizes Transient Receptor Potential Vanilloid Type 1 (TRPV1) via beta-arrestin-2-mediated cross-talk

Rowan, M. P., Bierbower, S. M., Eskander, M. A., Szteyn, K., Por, E. D., Gomez, R., Veldhuis, N. A., Bunnett, N. W. & Jeske, N. A., 2014, In : PLoS ONE. 9, 4, 12 p., e93688.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Advances in G protein-coupled receptor allostery: From function to structure

Christopoulos, A., 2014, In : Molecular Pharmacology. 86, 5, p. 463 - 478 16 p.

Research output: Contribution to journalArticleResearchpeer-review

Allosteric interactions at adenosine A1 and A3 receptors: New insights into the role of small molecules and receptor dimerization

Hill, S. J., May, L. T., Kellam, B. & Woolard, J., 2014, In : British Journal of Pharmacology. 171, 5, p. 1102 - 1113 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Allosteric modulation of M1 muscarinic acetylcholine receptor internalization and subcellular trafficking

Yeatman, H. R., Lane, J. R. D., Choy, K. H. C., Lambert, N., Sexton, P., Christopoulos, A. & Canals, M., 2014, In : Journal of Biological Chemistry. 289, 22, p. 15856 - 15866 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Allosteric targeting of receptor tyrosine kinases

De Smet, F., Christopoulos, A. & Carmeliet, P., 2014, In : Nature Biotechnology. 32, 11, p. 1113 - 1120 8 p.

Research output: Contribution to journalArticleResearchpeer-review

A new mechanism of allostery in a G protein-coupled receptor dimer

Lane, J. R. D., Donthamsetti, P., Shonberg, J., Draper-Joyce, C. J., Dentry, S., Michino, M., Shi, L., Lopez Munoz, L., Scammells, P. J., Capuano, B., Sexton, P., Javitch, J. A. & Christopoulos, A., 2014, In : Nature Chemical Biology. 10, 9, p. 745 - 752 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Angiotensin (1-7) as a Therapy to Prevent Rupture of Intracranial Aneurysms?

Kuruppu, D. M. S., Smith, A. I., Drummond, G. R. & Sobey, C. G., 2014, In : Hypertension. 64, 2, p. 222 - 223 2 p.

Research output: Contribution to journalLetterOther

Angiotensin-converting enzyme 2 mediates hyperfiltration associated with diabetes

Tikellis, C., Brown, R., Head, G. A., Cooper, M. E. & Thomas, M. C., 1 Apr 2014, In : American Journal of Physiology - Renal Physiology. 306, 7, p. F773 - F780 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Angiotensin type 2 receptor stimulation increases renal function in female, but not male, spontaneously hypertensive rats

Hilliard, L. M., Chow, C. L. E., Mirabito, K. M., Steckelings, U. M., Unger, T., Widdop, R. E. & Denton, K. M., 2014, In : Hypertension. 64, 2, p. 378 - 383 6 p.

Research output: Contribution to journalArticleResearchpeer-review

A novel agent with histone deacetylase inhibitory activity attenuates neointimal hyperplasia

Rahmatzadeh, M., Liu, H. B., Krishna, S. M., Gaspari, T. A., Spizzo, I., Widdop, R. E. & Dear, A. E., 2014, In : Cardiovascular Drugs and Therapy. 28, 5, p. 395 - 406 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Antenatal antioxidant treatment with melatonin to decrease newborn neurodevelopmental deficits and brain injury caused by fetal growth restriction

Miller, S. L., Yawno, T., Alers, N. O., Zakhem, M. E., Supramaniam, V. G., van Zyl, N., Sabaretnam, T., Loose, J. M., Drummond, G. R., Walker, D. W., Jenkin, G. & Wallace, E. M., 2014, In : Journal of Pineal Research. 56, 3, p. 283 - 294 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Antibodies in the pathogenesis of hypertension

Chan, C., Lieu, M., Toh, B-H., Kyaw, T. S., Bobik, A., Sobey, C. G. & Drummond, G. R., 2014, In : BioMed Research International. 2014, (Art. No: 504045), p. 1 - 9 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

A nuclear transport inhibitor that modulates the unfolded protein response and provides in vivo protection against lethal dengue virus infection

Fraser, J. E., Watanabe, S., Wang, C., Chan, W. K. K., Maher, B., Lopez-Denman, A., Hick, C. A., Wagstaff, K. M., Mackenzie, J. M., Sexton, P. M., Vasudevan, S. G. & Jans, D. A., 2014, In : Journal of Infectious Diseases. 210, 11, p. 1780 - 1791 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Biased agonism at G protein-coupled receptors: The promise and the challenges - A medicinal chemistry perspective

Shonberg, J., Lopez Munoz, L., Scammells, P. J., Christopoulos, A., Capuano, B. & Lane, J. R. D., 2014, In : Medicinal Research Reviews. 34, 6, p. 1286 - 1330 45 p.

Research output: Contribution to journalArticleResearchpeer-review

Brain immune cell composition and functional outcome after cerebral ischemia: comparison of two mouse strains

Kim, H. A., Whittle, S., Lee, S. S., Chu, H., Zhang, S., Wei, Z., Arumugam, T., Vinh, A., Drummond, G. R. & Sobey, C. G., 2014, In : Frontiers in Cellular Neuroscience. 8, 365, 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Cathepsin S causes inflammatory pain via biased agonism of PAR2 and TRPV4

Zhao, P., Lieu, T. M., Barlow, N., Metcalf, M., Veldhuis, N. A., Jensen, D. D., Kocan, M., Sostegni, S., Haerteis, S., Baraznenok, V. A., Henderson, I., Lindstrom, E., Guerrero-Alba, R., Valdez-Morales, E., Liedtke, W., McIntyre, P., Vanner, S., Korbmacher, C. & Bunnett, N. W., 2014, In : Journal of Biological Chemistry. 289, 39, p. 27215 - 27234 20 p.

Research output: Contribution to journalArticleResearchpeer-review

Characterization of a novel model incorporating airway epithelial damage and related fibrosis to the pathogenesis of asthma

Royce, S. G., Patel, K. P. & Samuel, C. S., 2014, In : Laboratory Investigation. 94, 12, p. 1326 - 1339 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Characterization of the novel positive allosteric modulator, LY2119620, at the muscarinic M(2) and M(4) receptors

Croy, C. H., Schober, D. A., Xiao, H., Quets, A., Christopoulos, A. & Felder, C. C., 2014, In : Molecular Pharmacology. 86, 1, p. 106 - 115 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Chironex fleckeri (box jellyfish) venom proteins: expansion of a cnidarian toxin family that elicits variable cytolytic and cardiovascular effects

Brinkman, D. L., Konstantakopoulos, N., McInerney, B., Mulvenna, J., Seymour, J. E., Isbister, G. K. & Hodgson, W. C., 2014, In : Journal of Biological Chemistry. 289, 8, p. 4798 - 4812 15 p.

Research output: Contribution to journalArticleResearchpeer-review

Chronic aldosterone administration causes Nox2-mediated increases in reactive oxygen species production and endothelial dysfunction in the cerebral circulation

Chrissobolis, S., Drummond, G. R., Faraci, F. M. & Sobey, C. G., 2014, In : Journal of hypertension. 32, 9, p. 1815 - 1821 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Comparative studies of the venom of a new Taipan species, Oxyuranus temporalis, with other members of its genus

Barber, C. M., Madaras, F., Turnbull, R. K., Morley, T., Dunstan, N., Allen, L., Kuchel, T., Mirtschin, P. & Hodgson, W. C., 2014, In : Toxins. 6, 7, p. 1979 - 1995 17 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Correction to Septic shock: Desperately seeking treatment [Clinical Science, 126 (2014), 31-39]

Huet, O. & Chin-Dusting, J. P. F., Mar 2014, In : Clinical Science. 126, 6, p. 459 1 p.

Research output: Contribution to journalComment / DebateOtherpeer-review

DC isoketal-modified proteins activate T cells and promote hypertension

Kirabo, A., Fontana, V., de Faria, A. P. C., Loperena, R., Galindo, C. L., Wu, J., Bikineyeva, A. T., Dikalov, S., Xiao, L., Chen, W., Saleh, M. A., Trott, D. W., Itani, H. A., Vinh, A., Amarnath, V., Amarnath, K., Guzik, T. J., Bernstein, K. E., Shen, X. G. Z., Shyr, Y. & 9 othersChen, S-C., Mernaugh, R. L., Laffer, C. L., Elijovich, F., Davies, S. S., Moreno, H., Madhur, M. S., Roberts II, L. J. & Harrison, D. G., 2014, In : Journal of Clinical Investigation. 124, 10, p. 4642 - 4656 15 p.

Research output: Contribution to journalArticleResearchpeer-review

Development of a photoactivatable allosteric ligand for the M1 muscarinic acetylcholine receptor

Davie, B. J., Sexton, P., Capuano, B., Christopoulos, A. & Scammells, P. J., 2014, In : ACS Chemical Neuroscience. 5, 10, p. 902 - 907 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Development of a radioligand, [(3)H]LY2119620, to probe the human M(2) and M(4) muscarinic receptor allosteric binding sites

Schober, D. A., Croy, C. H., Xiao, H., Christopoulos, A. & Felder, C. C., 2014, In : Molecular Pharmacology. 86, 1, p. 116 - 123 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Differential phenotypes of tissue-infiltrating T cells during angiotensin II-induced hypertension in mice

Wei, Z., Spizzo, I., Diep, H., Drummond, G. R., Widdop, R. E. & Vinh, A., 2014, In : PLoS ONE. 9, 12, 21 p., e114895.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Direct angiotensin AT2 receptor stimulation using a novel AT2 receptor agonist, compound 21, evokes neuroprotection in conscious hypertensive rats

McCarthy, C. A., Vinh, A., Miller, A. A., Hallberg, A., Alterman, M., Callaway, J. K. & Widdop, R. E., 2014, In : PLoS ONE. 9, 4 (Art. No: e95762), p. 1 - 10 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access