Research Output 1986 2019

2015

Ghrelin-related peptides exert protective effects in the cerebral circulation of male mice through a nonclassical ghrelin receptor(s)

Ku, J., Andrews, Z. B., Barsby, T., Reichenbach, A., Lemus, M. B., Drummond, G. R., Sleeman, M., Spencer, S. J., Sobey, C. G. & Miller, A. A., 2015, In : Endocrinology. 156, 1, p. 280 - 290 11 p.

Research output: Contribution to journalArticleResearchpeer-review

GPCR-mediated EGF receptor transactivation regulates TRPV4 action in the vasculature

Saifeddine, M., El-Daly, M., Mihara, K., Bunnett, N. W., McIntyre, P., Altier, C., Hollenberg, M. D. & Ramachandran, R., 2015, In : British Journal of Pharmacology. 172, 10, p. 2493-2506 14 p.

Research output: Contribution to journalArticleResearchpeer-review

GPCR structure, function, drug discovery and crystallography: report from Academia-Industry International Conference (UK Royal Society) Chicheley Hall, 1-2 September 2014

Heifetz, A., Schertler, G. F. X., Seifert, R., Tate, C. G., Sexton, P. M., Gurevich, V. V., Fourmy, D., Cherezov, V., Marshall, F., Storer, R. I., Moraes, I., Tikhonova, I., Tautermann, C., Hunt, P., Ceska, T., Hodgson, S., Bodkin, M., Singh, S., Law, R. & Biggin, P., 22 Aug 2015, In : Naunyn-Schmiedeberg's Archives of Pharmacology. 388, 8, p. 883-903 21 p., 1111.

Research output: Contribution to journalArticleOther

Open Access

G protein-coupled receptors: dynamic machines for signaling pain and itch

Geppetti, P., Veldhuis, N. A., Lieu, T. & Bunnett, N. W., 2015, In : Neuron. 88, 4, p. 635-649 15 p.

Research output: Contribution to journalArticleResearchpeer-review

Hydrogen sulfide treatment reduces blood pressure and oxidative stress in angiotensin II-induced hypertensive mice

Al-Magableh, M. R., Harper, B. K. & Hart, J. L., 2015, In : Hypertension Research. 38, 1, p. 13 - 20 8 p.

Research output: Contribution to journalArticleResearchpeer-review

IgG and EoE: Too soon for a paradigm shift away from IgE

Philpott, H., Royce, S. G., Nandurkar, S., Thien, F. C. K. & Gibson, P. R., 2015, In : Gastroenterology. 148, 2, p. 453 - 454 2 p.

Research output: Contribution to journalLetterOther

Inflammation-induced abnormalities in the subcellular localization and trafficking of the neurokinin 1 receptor in the enteric nervous system

Poole, D. P., Lieu, T. M., Pelayo, J-C., Eriksson, E. M. Y., Veldhuis, N. A. & Bunnett, N. W., 2015, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 309, 4, p. G248-G259 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Label-free (XIC) quantification of venom procoagulant and neurotoxin expression in related australian elapid snakes gives insight into venom toxicity evolution

Skejic, J., Steer, D. L., Dunstan, N. & Hodgson, W. C., 2015, In : Journal of Proteome Research. 14, 11, p. 4896 - 4906 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Lipopolysaccharide does not alter small airway reactivity in mouse lung slices

Donovan, C., Royce, S. G., Vlahos, R. & Bourke, J. E., 2015, In : PLoS ONE. 10, 3, 16 p., e0122069.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Mesenchymal stem cells and serelaxin synergistically abrogate established airway fibrosis in an experimental model of chronic allergic airways disease

Royce, S. G., Shen, M., Patel, K. P., Huuskes, B., Ricardo, S. D. & Samuel, C. S., 2015, In : Stem Cell Research. 15, 3, p. 495 - 505 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Molecular insights into metabotropic glutamate receptor allosteric modulations

Gregory, K. J. & Conn, P. J., 1 Jul 2015, In : Molecular Pharmacology. 88, 1, p. 188-202 15 p.

Research output: Contribution to journalShort SurveyResearchpeer-review

Molecular mechanism of action of triazolobenzodiazepinone agonists of the type 1 cholecystokinin receptor. Possible cooperativity across the receptor homodimeric complex

Desai, A. J., Lam, P. C. H., Orry, A., Abagyan, R., Christopoulos, A., Sexton, P. & Miller, L. J., 2015, In : Journal of Medicinal Chemistry. 58, 24, p. 9562-9577 16 p.

Research output: Contribution to journalArticleResearchpeer-review

Motor and behavioral phenotype in conditional mutants with targeted ablation of cortical D1 dopamine receptor-expressing cells

Jiang, L., O'Leary, C., Kim, H. H. A., Parish, C. L., Massalas, J. S., Waddington, J. L., Ehrlich, M. E., Schutz, G. M., Gantois, I., Lawrence, A. J. & Drago, J., 2015, In : Neurobiology of Disease. 76, p. 137 - 158 22 p.

Research output: Contribution to journalArticleResearchpeer-review

MouseMove: an open source program for semi-automated analysis of movement and cognitive testing in rodents

Samson, A. L., Ju, L., Kim, H. A., Zhang, S., Lee, J. A. A., Sturgeon, S. A., Sobey, C. G., Jackson, S. & Schoenwaelder, S. M., 2015, In : Scientific Reports. 5, (Art. No: 16171), p. 1 - 11 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Neutrophil elastase activates protease-activated receptor-2 (PAR2) and transient receptor potential vanilloid 4 (TRPV4) to cause inflammation and pain

Zhao, P., Lieu, T. M., Barlow, N., Sostegni, S., Haerteis, S., Korbmacher, C., Liedtke, W., Jimenez-Vargas, N. N., Vanner, S. & Bunnett, N. W., 2015, In : Journal of Biological Chemistry. 290, 22, p. 13875 - 13887 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Nitroxyl: a vasodilator of human vessels that is not susceptible to tolerance

Andrews, K. L., Lumsden, N. G., Farry, J., Jefferis, A-M., Kemp-Harper, B. K. & Chin-Dusting, J. P. F., 2015, In : Clinical Science. 129, 2, p. 179 - 187 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Nontypeable Haemophilus influenzae induces sustained lung oxidative stress and protease expression

King, P. T., Sharma, R., O'Sullivan, K., Selemidis, S., Lim, S., Radhakrishna, N., Lo, C. Y-W., Prasad, J., Callaghan, J. M., McLaughlin, P., Farmer, M., Steinfort, D. P., Jennings, B. R., Ngui, J., Broughton, B. R. S., Thomas, B., Essilfie, A-T., Hickey, M. J., Holmes, P., Hansbro, P. M. & 2 othersBardin, P. G. & Holdsworth, S. R., 2015, In : PLoS ONE. 10, 3 (Art. No.: e0120371), p. 1 - 17 17 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Novel allosteric modulators of G protein-coupled receptors

Gentry, P. R., Sexton, P. M. & Christopoulos, A., 2015, In : Journal of Biological Chemistry. 290, 32, p. 19478-19488 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Novel GPCR paradigms at the μ-opioid receptor

Thompson, G. L., Kelly, E., Christopoulos, A. & Canals, M., 2015, In : British Journal of Pharmacology. 172, 2, p. 287-296 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Nox1 upregulates the function of vascular T-type calcium channels following chronic nitric oxide deficit

Howitt, L., Matthaei, K. I., Drummond, G. R. & Hill, C. E., 2015, In : Pflugers Archiv-European Journal of Physiology. 467, 4, p. 727 - 735 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Obligatory role for B cells in the development of angiotensin II-dependent hypertension

Chan, C. T-L., Sobey, C. G., Lieu, M., Ferens, D. M., Kett, M. M., Diep, H., Kim, H. H. A., Krishnan, S. M., Lewis, C. V., Salimova, E., Tipping, P. G., Vinh, A., Samuel, C. S., Peter, K., Guzik, T. J., Kyaw, T. S., Toh, B-H., Bobik, A. & Drummond, G. R., 2015, In : Hypertension. 66, 5, p. 1023 - 1033 11 p.

Research output: Contribution to journalArticleResearchpeer-review

P2Y1 receptor activation of the TRPV4 ion channel enhances purinergic signaling in satellite glial cells

Rajasekhar, P., Poole, D. P., Liedtke, W., Bunnett, N. W. & Veldhuis, N. A., 2015, In : Journal of Biological Chemistry. 290, 48, p. 29051-29062 12 p.

Research output: Contribution to journalArticleResearchpeer-review

PcTx1 affords neuroprotection in a conscious model of stroke in hypertensive rats via selective inhibition of ASIC1a

McCarthy, C. A., Rash, L. D., Chassagnon, I. R., King, G. F. & Widdop, R. E., 2015, In : Neuropharmacology. 99, (Art. No: 5986), p. 650 - 657 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Pin1 promotes neuronal death in stroke by stabilizing Notch intracellular domain

Baik, S-H., Fane, M., Park, J. H., Cheng, Y-L., Fann, D. Y-W., Yun, U. J., Choi, Y., Park, J-S., Chai, B. H., Park, J. S., Back, S. H., Jeong, J. I., Jang, Y. J., Bahn, G., Lee, J-Y., Li, Y., Sobey, C. G., Uchida, T., Park, J. H., Kim, H. T. & 3 othersTang, S-C., Arumugam, T. V. & Jo, D-G., 2015, In : Annals of Neurology. 77, 3, p. 504 - 516 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Proof of concept study for designed multiple ligands targeting the dopamine D2, serotonin 5-HT2A, and muscarinic M1 acetylcholine receptors

Szabo, M., Lim, H. D., Klein Herenbrink, C., Christopoulos, A., Lane, J. R. D. & Capuano, B., 2015, In : Journal of Medicinal Chemistry. 58, 3, p. 1550 - 1555 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Quantification and potential functions of endogenous agonists of transient receptor potential channels in patients with irritable bowel syndrome

Cenac, N., Bautzova, T., Le Faouder, P., Veldhuis, N. A., Poole, D. P., Rolland, C., Bertrand, J., Liedtke, W., Dubourdeau, M., Bertrand-Michel, J., Zecchi, L., Stanghellini, V., Bunnett, N. W., Barbara, G. & Vergnolle, N., 2015, In : Gastroenterology. 149, 2, p. 433-444 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Receptor expression modulates calcium-sensing receptor mediated intracellular Ca2+ mobilization

Brennan, S. C., Mun, H., Leach, K., Kuchel, P. W., Christopoulos, A. & Conigrave, A., 2015, In : Endocrinology. 156, 4, p. 1330 - 1342 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Risk of major cardiovascular events in people with down syndrome

Sobey, C. G., Judkins, C. P., Sundararajan, V., Phan, T. G., Drummond, G. R. & Srikanth, V. K., 2015, In : PLoS ONE. 10, 9, 11 p., e0137093.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Rosiglitazone elicits in vitro relaxation in airways and precision cut lung slices from a mouse model of chronic allergic airways disease

Donovan, C., Bailey, S. R., Tran, J., Haitsma, G., Ibrahim, Z. A., Foster, S. R., Tang, M. L. K., Royce, S. G. & Bourke, J. E., 2015, In : American Journal of Physiology - Lung Cellular and Molecular Physiology. 309, 10, p. 1219 - 1228 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Seasonal recurrence of food bolus obstruction in eosinophilic esophagitis

Philpott, H., Nandurkar, S., Thien, F. C. K., Bloom, S. D., Lin, E., Goldberg, R., Boyapati, R., Finch, A., Royce, S. G. & Gibson, P. R., 2015, In : Internal Medicine Journal. 45, 9, p. 939 - 943 5 p.

Research output: Contribution to journalArticleResearchpeer-review

Sensitisation of TRPV4 by PAR2 is independent of intracellular calcium signalling and can be mediated by the biased agonist neutrophil elastase

Sostegni, S., Diakov, A., McIntyre, P., Bunnett, N., Korbmacher, C. & Haerteis, S., 2015, In : Pflugers Archiv-European Journal of Physiology. 467, 4, p. 687-701 15 p.

Research output: Contribution to journalArticleResearchpeer-review

Serelaxin-mediated signal transduction in human vascular cells: bell-shaped concentration-response curves reflect differential coupling to G proteins

Sarwar, M., Samuel, C. S., Bathgate, R. A., Stewart, D. R. & Summers, R. J., 2015, In : British Journal of Pharmacology. 172, 4, p. 1005-1019 15 p.

Research output: Contribution to journalArticleResearchpeer-review

Sex differences in AT2R expression and action

Hilliard, L. M., Mirabito, K. M., Widdop, R. E. & Denton, K. M., 2015, The Protective Arm of the Renin-Angiotensin System: Functional Aspects and Therapeutic Implications. Unger, T., Steckelings, U. M. & dos Santos, R. A. S. (eds.). 1st ed. London UK: Elsevier, p. 125 - 130 6 p.

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Researchpeer-review

Specific role of dietary fat in modifying cardiovascular and locomotor activity 24-h rhythms

Barzel, B., Lim, K. J., Burke, S. L., Armitage, J. A. & Head, G. A., 2015, In : Chronobiology International. 32, 5, p. 668 - 676 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Stonefish toxin defines an ancient branch of the perforin-like superfamily

Ellisdon, A. M., Reboul, C. F., Panjikar, S., Huynh, K., Oellig, C. A., Winter, K. L., Dunstone, M. A., Hodgson, W. C., Seymour, J. E., Dearden, P. K., Tweten, R. K., Whisstock, J. C. & McGowan, S., 2015, In : Proceedings of the National Academy of Sciences. 112, 50, p. 15360 - 15365 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Structural and functional correlations in a large animal model of bleomycin-induced pulmonary fibrosis

Organ, L., Bacci, B., Koumoundouros, E., Barcham, G. J., Milne, M., Kimpton, W. G., Samuel, C. S. & Snibson, K. J., 2015, In : BMC Pulmonary Medicine. 15, 1 , 15 p., 81.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Structural determinants for binding to angiotensin converting enzyme 2 (ACE2) and angiotensin receptors 1 and 2

Clayton, D. J., Hanchapola, I., Thomas, W. G., Widdop, R. E., Smith, A. I., Perlmutter, P. & Aguilar, M. M. I. . I., 2015, In : Frontiers in Pharmacology. 6, (Art. No: 5), p. 1 - 9 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Synthesis and pharmacological evaluation of M4 muscarinic receptor positive allosteric modulators derived from VU10004

Huynh, T., Valant, C., Crosby, I. T., Sexton, P., Christopoulos, A. & Capuano, B., 2015, In : ACS Chemical Neuroscience. 6, 6, p. 838 - 844 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Synthesis of six mexiletine derivatives with isoindolines attached as potential antioxidants and their evaluation as cardioprotective agents

Chau, B. A., Drummond, G. R., Jackson, W. R., Jarrott, B., Miller, A. A., Subasinghe, K. R., Tan, C. Y. R., White, P. J., Wright, C. E. & Ziogas, J., 2015, In : MedChemComm. 6, 4, p. 634-639 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Synthetic covalently linked dimeric form of H2 relaxin retains native RXFP1 activity and has improved in vitro serum stability

Nair, V. B., Bathgate, R. A. D., Separovic, F., Samuel, C. S., Hossain, M. A. & Wade, J. D., 2015, In : BioMed Research International. 2015, 10 p., 731852.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Targeting of transient receptor potential channels in digestive disease

Poole, D. P., Lieu, T., Veldhuis, N. A., Rajasekhar, P. & Bunnett, N. W., 2015, TRP Channels as Therapeutic Targets: From Basic Science to Clinical Use. Szallasi, A. (ed.). London UK: Elsevier, p. 385-403 19 p.

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Researchpeer-review

The G protein-coupled receptor-transient receptor potential channel axis: molecular insights for targeting disorders of sensation and inflammation

Veldhuis, N. A., Poole, D. P., Grace, M., McIntyre, P. & Bunnett, N. W., 2015, In : Pharmacological Reviews. 67, 1, p. 36 - 73 38 p.

Research output: Contribution to journalArticleResearchpeer-review

Towards tissue-specific pharmacology: insights from the calcium-sensing receptor as a paradigm for GPCR (patho)physiological bias

Leach, K., Conigrave, A. D., Sexton, P. M. & Christopoulos, A., 2015, In : Trends in Pharmacological Sciences. 36, 4, p. 215-225 11 p.

Research output: Contribution to journalArticleResearchpeer-review