Research Output

2015

Angiotensis-based peptides as AT2R agonists

Jones, E. S., Wang, Y., Del Borgo, M. P., Denton, K. M., Aguilar, M-I. I. & Widdop, R. E., 2015, The Protective Arm of the Renin-Angiotensin System: Functional Aspects and Therapeutic Implications. Unger, T., Steckelings, U. M. & dos Santos, R. A. S. (eds.). 1st ed. London UK: Elsevier, p. 141 - 147 7 p.

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Otherpeer-review

1 Citation (Scopus)

A novel segmental challenge model for bleomycin-induced pulmonary fibrosis in sheep

Organ, L., Bacci, B., Koumoundouros, E., Barcham, G., Kimpton, W., Nowell, C., Samuel, C. & Snibson, K., 2015, In : Experimental Lung Research. 41, 3, p. 115-134 20 p.

Research output: Contribution to journalArticleResearchpeer-review

10 Citations (Scopus)

A positive allosteric modulator of the adenosine A1 receptor selectively inhibits primary afferent synaptic transmission in a neuropathic pain model

Imlach, W. L., Bhola, R. F., May, L. T., Christopoulos, A. & Christie, M. J., 2015, In : Molecular Pharmacology. 88, 3, p. 460-468 9 p.

Research output: Contribution to journalArticleResearchpeer-review

19 Citations (Scopus)

A structure-activity relationship study of the positive allosteric modulator LY2033298 at the M4 muscarinic acetylcholine receptor

Szabo, M., Huynh, T., Valant, C., Lane, J. R., Sexton, P. M., Christopoulos, A. & Capuano, B., 2015, In : MedChemComm. 6, 11, p. 1998-2003 6 p.

Research output: Contribution to journalArticleResearchpeer-review

5 Citations (Scopus)

AT2R, vascular effects, and blood pressure

Dias Baraldi, D., Jones, E. S., Hilliard, L. M., Del Borgo, M. P., Gaspari, T. A., McCarthy, C. A., Vinh, A., Weungoda, I., Aguilar, M-I. I., Denton, K. M. & Widdop, R. E., 2015, The Protective Arm of the Renin-Angiotensin System: Functional Aspects and Therapeutic Implications. Unger, T., Steckelings, U. M. & dos Santos, R. A. S. (eds.). 1st ed. London UK: Elsevier, p. 49 - 55 7 p.

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Otherpeer-review

Biased agonism and biased allosteric modulation at the CB1 cannabinoid receptors

Khajehali, E., Malone, D. T., Glass, M., Sexton, P., Christopoulos, A. & Leach, K., 2015, In : Molecular Pharmacology. 88, 2, p. 368-379 12 p.

Research output: Contribution to journalArticleResearchpeer-review

75 Citations (Scopus)

Biased agonism of endogenous opioid peptides at the μ-opioid receptor

Thompson, G. L., Lane, J. R. D., Coudrat, T., Sexton, P., Christopoulos, A. & Canals, M., 2015, In : Molecular Pharmacology. 88, 2, p. 335-346 12 p.

Research output: Contribution to journalArticleResearchpeer-review

52 Citations (Scopus)

Biased allosteric modulation at the CaS receptor engendered by structurally diverse calcimimetics

Cook, A. E., Mistry, S. N., Gregory, K. J., Furness, S. G. B., Sexton, P., Scammells, P. J., Conigrave, A., Christopoulos, A. & Leach, K., 2015, In : British Journal of Pharmacology. 172, 1, p. 185 - 200 16 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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45 Citations (Scopus)

Chronic administration of the nitroxyl donor 1-nitrosocyclo hexyl acetate limits left ventricular diastolic dysfunction in a mouse model of diabetes mellitus in vivo

Cao, N., Wong, Y. G., Rosli, S., Kiriazis, H., Huynh, K., Qin, C. H., Du, X-J., Kemp-Harper, B. K. & Ritchie, R. H., 2015, In : Circulation: Heart Failure. 8, 3, p. 572 - 581 10 p.

Research output: Contribution to journalArticleResearchpeer-review

16 Citations (Scopus)

Combination therapy of mesenchymal stem cells and serelaxin effectively attenuates renal fibrosis in obstructive nephropathy

Huuskes, B., Wise, A. F., Cox, A. J., Lim, E. X. F., Payne, N. L., Kelly, D. J., Samuel, C. S. & Ricardo, S. D., 2015, In : The FASEB Journal. 29, 2, p. 540 - 553 14 p.

Research output: Contribution to journalArticleResearchpeer-review

34 Citations (Scopus)

Danger signals in stroke

Gelderblom, M., Sobey, C. G., Kleinschnitz, C. & Magnus, T., 2015, In : Ageing Research Reviews. 24, Pt. A, p. 77 - 82 6 p.

Research output: Contribution to journalArticleResearchpeer-review

18 Citations (Scopus)

Demonstration of elevated levels of active cathepsin S in dextran sulfate sodium colitis using a new activatable probe

Barlow, N., Nasser, Y., Zhao, P., Sharma, N., Guerrero-Alba, R., Edgington-Mitchell, L. E., Lieu, T., Veldhuis, N. A., Poole, D. P., Conner, J. W., Lindstrom, E., Craig, A. W., Graham, B., Vanner, S. J. & Bunnett, N. W., 2015, In : Neurogastroenterology and Motility. 27, 11, p. 1675-1680 6 p.

Research output: Contribution to journalArticleResearchpeer-review

2 Citations (Scopus)
Open Access
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6 Citations (Scopus)

Detection and quantification of intracellular signaling using FRET-based biosensors and high content imaging

Halls, M. L., Poole, D. P., Ellisdon, A. M., Nowell, C. & Canals, M., 2015, G Protein-Coupled Receptors in Drug Discovery: Methods and Protocols. Filizola, M. (ed.). 2 ed. New York NY USA: Springer, Vol. 1335. p. 131-161 31 p. (Methods in Molecular Biology; vol. 1335, no. 2).

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Otherpeer-review

Open Access
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14 Citations (Scopus)

Development of a highly selective allosteric antagonist radioligand for the type 1 cholecystokinin receptor and elucidation of its molecular basis of binding

Dong, M., Vattelana, A. M., Lam, P. C. H., Orry, A., Abagyan, R., Christopoulos, A., Sexton, P., Haines, D. R. & Miller, L. J., 2015, In : Molecular Pharmacology. 87, 1, p. 130-140 11 p.

Research output: Contribution to journalArticleResearchpeer-review

7 Citations (Scopus)

Dietary sulforaphane in cancer chemoprevention: the role of epigenetic regulation and HDAC inhibition

Tortorella, S., Royce, S. G., Licciardi, P. V. & Karagiannis, T. C., 2015, In : Antioxidants and Redox Signaling. 22, 16, p. 1382 - 1424 43 p.

Research output: Contribution to journalArticleResearchpeer-review

90 Citations (Scopus)

Differential activation of renal sympathetic burst amplitude and frequency during hypoxia, stress and baroreflexes with chronic angiotensin treatment

Lim, K. J., Burke, S. L., Moretti, J-L. & Head, G. A., 2015, In : Experimental Physiology. 100, 10, p. 1132 - 1144 13 p.

Research output: Contribution to journalArticleResearchpeer-review

8 Citations (Scopus)
Open Access
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12 Citations (Scopus)

Discovery, synthesis, and molecular pharmacology of selective positive allosteric modulators of the δ-opioid receptor

Burford, N. T., Livingston, K. E., Canals, M., Ryan, M. R., Budenholzer, L. M. L., Han, Y., Shang, Y., Herbst, J. J., O'Connell, J., Banks, M., Zhang, L., Filizola, M., Bassoni, D. L., Wehrman, T. S., Christopoulos, A., Traynor, J. R., Gerritz, S. W. & Alt, A., 2015, In : Journal of Medicinal Chemistry. 58, 10, p. 4220-4229 10 p.

Research output: Contribution to journalArticleResearchpeer-review

32 Citations (Scopus)

Discovery of a novel class of negative allosteric modulator of the dopamine D2 receptor through fragmentation of a bitopic ligand

Mistry, S. N., Shonberg, J., Draper-Joyce, C. J., Klein Herenbrink, C., Michino, M., Shi, L., Christopoulos, A., Capuano, B., Scammells, P. J. & Lane, J. R. D., 2015, In : Journal of Medicinal Chemistry. 58, 17, p. 6819-6843 25 p.

Research output: Contribution to journalArticleResearchpeer-review

35 Citations (Scopus)

DNAM-1 expression marks an alternative program of NK cell maturation

Martinet, L., de Andrade, L. F., Guillerey, C., Lee, J. S., Liu, J., Souza-Fonseca-Guimaraes, F., Hutchinson, D. S., Kolesnik, T. B., Nicholson, S. E., Huntington, N. D. & Smyth, M. J., 2015, In : Cell Reports. 11, 1, p. 85 - 97 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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59 Citations (Scopus)

Effect of a broad-specificity chemokine-binding protein on brain leukocyte infiltration and infarct development

Lee, S. S., Chu, H. X., Kim, H. A. H., Real, N. C., Sharif, S., Fleming, S. B., Mercer, A. A., Wise, L., Drummond, G. R. & Sobey, C. G., 2015, In : Stroke. 46, 2, p. 537 - 544 8 p.

Research output: Contribution to journalArticleResearchpeer-review

21 Citations (Scopus)

Effect of a selective mas receptor agonist in cerebral ischemia in vitro and in vivo

Lee, S. S., Evans, M. A., Chu, H. X., Kim, H. H. A., Widdop, R. E., Drummond, G. R. & Sobey, C. G., 2015, In : PLoS ONE. 10, 11, 11 p., e0142087.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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13 Citations (Scopus)

Electrophysiological, electroanatomical, and structural remodeling of the atria as consequences of sustained obesity

Mahajan, R., Lau, D. H., Brooks, A. G., Shipp, N. J., Manavis, J., Wood, J. P. M., Finnie, J. W., Samuel, C. S., Royce, S. G., Twomey, D. J., Thanigaimani, S., Kalman, J. M. & Sanders, P., 2015, In : Journal of the American College of Cardiology. 66, 1, p. 1 - 11 11 p.

Research output: Contribution to journalArticleResearchpeer-review

157 Citations (Scopus)

Emerging roles of the {gamma}-secretase-notch axis in inflammation

Cheng, Y-L., Choi, Y., Sobey, C. G., Arumugam, T. V. & Jo, D-G., 2015, In : Pharmacology and Therapeutics. 147, p. 80 - 90 11 p.

Research output: Contribution to journalArticleResearchpeer-review

15 Citations (Scopus)

Endogenous allosteric modulators of G protein-coupled receptors

Van Der Westhuizen, E. T., Valant, C., Sexton, P. & Christopoulos, A., 2015, In : Journal of Pharmacology and Experimental Therapeutics. 353, 2, p. 246 - 260 15 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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64 Citations (Scopus)

Endosomal gene expression: a new indicator for prostate cancer patient prognosis?

Johnson, I. R. D., Parkinson-Lawrence, E. J., Keegan, H., Spillane, C. D., Barry-O'Crowley, J., Watson, W. R., Selemidis, S., Butler, L. M., O'Leary, J. J. & Brooks, D. A., 2015, In : Oncotarget. 6, 35, p. 37919 - 37929 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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15 Citations (Scopus)

Eosinophilic esophagitis: A clinicopathological review

Philpott, H., Nandurkar, S., Thien, F., Gibson, P. R. & Royce, S. G., 2015, In : Pharmacology and Therapeutics. 146, p. 12 - 22 11 p.

Research output: Contribution to journalArticleResearchpeer-review

15 Citations (Scopus)

Erratum: The pharmacokinetics and pharmacodynamics of severe aldicarb toxicity after overdose (Clinical Toxicology (2015) (1-3))

Michael, A. P., Mostafa, A., Cooper, J. M., Grice, J. E., Roberts, M. S. & Isbister, G. K., 9 Aug 2015, In : Clinical Toxicology. 53, 7, p. 788 1 p.

Research output: Contribution to journalComment / DebateOtherpeer-review

Evidence that Ly6C(hi) monocytes are protective in acute ischemic stroke by promoting M2 macrophage polarization

Chu, H. X., Broughton, B. R. S., Kim, H. H. A., Lee, S. S., Drummond, G. R. & Sobey, C. G., 2015, In : Stroke. 46, 7, p. 1929 - 1937 9 p.

Research output: Contribution to journalArticleResearchpeer-review

61 Citations (Scopus)

Fatty acid-binding proteins 1 and 2 differentially modulate the activation of peroxisome proliferator-activated receptor alpha in a ligand-selective manner

Hughes, M. L. R., Liu, B., Halls, M. L., Wagstaff, K. M., Patil, R., Velkov, T., Jans, D. A., Bunnett, N. W., Scanlon, M. & Porter, C. J., 2015, In : The Journal of Biological Chemistry. 290, 22, p. 13895 - 13906 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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22 Citations (Scopus)

Ghrelin-related peptides exert protective effects in the cerebral circulation of male mice through a nonclassical ghrelin receptor(s)

Ku, J., Andrews, Z. B., Barsby, T., Reichenbach, A., Lemus, M. B., Drummond, G. R., Sleeman, M., Spencer, S. J., Sobey, C. G. & Miller, A. A., 2015, In : Endocrinology. 156, 1, p. 280 - 290 11 p.

Research output: Contribution to journalArticleResearchpeer-review

21 Citations (Scopus)

GPCR-mediated EGF receptor transactivation regulates TRPV4 action in the vasculature

Saifeddine, M., El-Daly, M., Mihara, K., Bunnett, N. W., McIntyre, P., Altier, C., Hollenberg, M. D. & Ramachandran, R., 2015, In : British Journal of Pharmacology. 172, 10, p. 2493-2506 14 p.

Research output: Contribution to journalArticleResearchpeer-review

24 Citations (Scopus)

GPCR structure, function, drug discovery and crystallography: report from Academia-Industry International Conference (UK Royal Society) Chicheley Hall, 1-2 September 2014

Heifetz, A., Schertler, G. F. X., Seifert, R., Tate, C. G., Sexton, P. M., Gurevich, V. V., Fourmy, D., Cherezov, V., Marshall, F., Storer, R. I., Moraes, I., Tikhonova, I., Tautermann, C., Hunt, P., Ceska, T., Hodgson, S., Bodkin, M., Singh, S., Law, R. & Biggin, P., 22 Aug 2015, In : Naunyn-Schmiedeberg's Archives of Pharmacology. 388, 8, p. 883-903 21 p., 1111.

Research output: Contribution to journalArticleOther

Open Access
25 Citations (Scopus)

G protein-coupled receptors: dynamic machines for signaling pain and itch

Geppetti, P., Veldhuis, N. A., Lieu, T. & Bunnett, N. W., 2015, In : Neuron. 88, 4, p. 635-649 15 p.

Research output: Contribution to journalArticleResearchpeer-review

58 Citations (Scopus)

Hydrogen sulfide treatment reduces blood pressure and oxidative stress in angiotensin II-induced hypertensive mice

Al-Magableh, M. R., Harper, B. K. & Hart, J. L., 2015, In : Hypertension Research. 38, 1, p. 13 - 20 8 p.

Research output: Contribution to journalArticleResearchpeer-review

54 Citations (Scopus)

IgG and EoE: Too soon for a paradigm shift away from IgE

Philpott, H., Royce, S. G., Nandurkar, S., Thien, F. C. K. & Gibson, P. R., 2015, In : Gastroenterology. 148, 2, p. 453 - 454 2 p.

Research output: Contribution to journalLetterOther

5 Citations (Scopus)

Inflammation-induced abnormalities in the subcellular localization and trafficking of the neurokinin 1 receptor in the enteric nervous system

Poole, D. P., Lieu, T. M., Pelayo, J-C., Eriksson, E. M. Y., Veldhuis, N. A. & Bunnett, N. W., 2015, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 309, 4, p. G248-G259 12 p.

Research output: Contribution to journalArticleResearchpeer-review

12 Citations (Scopus)
73 Citations (Scopus)

Label-free (XIC) quantification of venom procoagulant and neurotoxin expression in related australian elapid snakes gives insight into venom toxicity evolution

Skejic, J., Steer, D. L., Dunstan, N. & Hodgson, W. C., 2015, In : Journal of Proteome Research. 14, 11, p. 4896 - 4906 11 p.

Research output: Contribution to journalArticleResearchpeer-review

2 Citations (Scopus)
2 Citations (Scopus)

Lipopolysaccharide does not alter small airway reactivity in mouse lung slices

Donovan, C., Royce, S. G., Vlahos, R. & Bourke, J. E., 2015, In : PLoS ONE. 10, 3, 16 p., e0122069.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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4 Citations (Scopus)
58 Citations (Scopus)

Mesenchymal stem cells and serelaxin synergistically abrogate established airway fibrosis in an experimental model of chronic allergic airways disease

Royce, S. G., Shen, M., Patel, K. P., Huuskes, B., Ricardo, S. D. & Samuel, C. S., 2015, In : Stem Cell Research. 15, 3, p. 495 - 505 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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23 Citations (Scopus)

Molecular insights into metabotropic glutamate receptor allosteric modulations

Gregory, K. J. & Conn, P. J., 1 Jul 2015, In : Molecular Pharmacology. 88, 1, p. 188-202 15 p.

Research output: Contribution to journalShort SurveyResearchpeer-review

30 Citations (Scopus)

Molecular mechanism of action of triazolobenzodiazepinone agonists of the type 1 cholecystokinin receptor. Possible cooperativity across the receptor homodimeric complex

Desai, A. J., Lam, P. C. H., Orry, A., Abagyan, R., Christopoulos, A., Sexton, P. & Miller, L. J., 2015, In : Journal of Medicinal Chemistry. 58, 24, p. 9562-9577 16 p.

Research output: Contribution to journalArticleResearchpeer-review

10 Citations (Scopus)

Motor and behavioral phenotype in conditional mutants with targeted ablation of cortical D1 dopamine receptor-expressing cells

Jiang, L., O'Leary, C., Kim, H. H. A., Parish, C. L., Massalas, J. S., Waddington, J. L., Ehrlich, M. E., Schutz, G. M., Gantois, I., Lawrence, A. J. & Drago, J., 2015, In : Neurobiology of Disease. 76, p. 137 - 158 22 p.

Research output: Contribution to journalArticleResearchpeer-review

7 Citations (Scopus)

MouseMove: an open source program for semi-automated analysis of movement and cognitive testing in rodents

Samson, A. L., Ju, L., Kim, H. A., Zhang, S., Lee, J. A. A., Sturgeon, S. A., Sobey, C. G., Jackson, S. & Schoenwaelder, S. M., 2015, In : Scientific Reports. 5, (Art. No: 16171), p. 1 - 11 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
23 Citations (Scopus)

Neutrophil elastase activates protease-activated receptor-2 (PAR2) and transient receptor potential vanilloid 4 (TRPV4) to cause inflammation and pain

Zhao, P., Lieu, T. M., Barlow, N., Sostegni, S., Haerteis, S., Korbmacher, C., Liedtke, W., Jimenez-Vargas, N. N., Vanner, S. & Bunnett, N. W., 2015, In : The Journal of Biological Chemistry. 290, 22, p. 13875 - 13887 13 p.

Research output: Contribution to journalArticleResearchpeer-review

69 Citations (Scopus)