Research Output 1986 2019

2015

Development of a highly selective allosteric antagonist radioligand for the type 1 cholecystokinin receptor and elucidation of its molecular basis of binding

Dong, M., Vattelana, A. M., Lam, P. C. H., Orry, A., Abagyan, R., Christopoulos, A., Sexton, P., Haines, D. R. & Miller, L. J., 2015, In : Molecular Pharmacology. 87, 1, p. 130-140 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Dietary sulforaphane in cancer chemoprevention: the role of epigenetic regulation and HDAC inhibition

Tortorella, S., Royce, S. G., Licciardi, P. V. & Karagiannis, T. C., 2015, In : Antioxidants and Redox Signaling. 22, 16, p. 1382 - 1424 43 p.

Research output: Contribution to journalArticleResearchpeer-review

Differential activation of renal sympathetic burst amplitude and frequency during hypoxia, stress and baroreflexes with chronic angiotensin treatment

Lim, K. J., Burke, S. L., Moretti, J-L. & Head, G. A., 2015, In : Experimental Physiology. 100, 10, p. 1132 - 1144 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Discovery, synthesis, and molecular pharmacology of selective positive allosteric modulators of the δ-opioid receptor

Burford, N. T., Livingston, K. E., Canals, M., Ryan, M. R., Budenholzer, L. M. L., Han, Y., Shang, Y., Herbst, J. J., O'Connell, J., Banks, M., Zhang, L., Filizola, M., Bassoni, D. L., Wehrman, T. S., Christopoulos, A., Traynor, J. R., Gerritz, S. W. & Alt, A., 2015, In : Journal of Medicinal Chemistry. 58, 10, p. 4220-4229 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Discovery of a novel class of negative allosteric modulator of the dopamine D2 receptor through fragmentation of a bitopic ligand

Mistry, S. N., Shonberg, J., Draper-Joyce, C. J., Klein Herenbrink, C., Michino, M., Shi, L., Christopoulos, A., Capuano, B., Scammells, P. J. & Lane, J. R. D., 2015, In : Journal of Medicinal Chemistry. 58, 17, p. 6819-6843 25 p.

Research output: Contribution to journalArticleResearchpeer-review

DNAM-1 expression marks an alternative program of NK cell maturation

Martinet, L., de Andrade, L. F., Guillerey, C., Lee, J. S., Liu, J., Souza-Fonseca-Guimaraes, F., Hutchinson, D. S., Kolesnik, T. B., Nicholson, S. E., Huntington, N. D. & Smyth, M. J., 2015, In : Cell Reports. 11, 1, p. 85 - 97 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Effect of a broad-specificity chemokine-binding protein on brain leukocyte infiltration and infarct development

Lee, S. S., Chu, H. X., Kim, H. A. H., Real, N. C., Sharif, S., Fleming, S. B., Mercer, A. A., Wise, L., Drummond, G. R. & Sobey, C. G., 2015, In : Stroke. 46, 2, p. 537 - 544 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Effect of a selective mas receptor agonist in cerebral ischemia in vitro and in vivo

Lee, S. S., Evans, M. A., Chu, H. X., Kim, H. H. A., Widdop, R. E., Drummond, G. R. & Sobey, C. G., 2015, In : PLoS ONE. 10, 11, 11 p., e0142087.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Electrophysiological, electroanatomical, and structural remodeling of the atria as consequences of sustained obesity

Mahajan, R., Lau, D. H., Brooks, A. G., Shipp, N. J., Manavis, J., Wood, J. P. M., Finnie, J. W., Samuel, C. S., Royce, S. G., Twomey, D. J., Thanigaimani, S., Kalman, J. M. & Sanders, P., 2015, In : Journal of the American College of Cardiology. 66, 1, p. 1 - 11 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Emerging roles of the {gamma}-secretase-notch axis in inflammation

Cheng, Y-L., Choi, Y., Sobey, C. G., Arumugam, T. V. & Jo, D-G., 2015, In : Pharmacology and Therapeutics. 147, p. 80 - 90 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Endogenous allosteric modulators of G protein-coupled receptors

Van Der Westhuizen, E. T., Valant, C., Sexton, P. & Christopoulos, A., 2015, In : Journal of Pharmacology and Experimental Therapeutics. 353, 2, p. 246 - 260 15 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Endosomal gene expression: a new indicator for prostate cancer patient prognosis?

Johnson, I. R. D., Parkinson-Lawrence, E. J., Keegan, H., Spillane, C. D., Barry-O'Crowley, J., Watson, W. R., Selemidis, S., Butler, L. M., O'Leary, J. J. & Brooks, D. A., 2015, In : Oncotarget. 6, 35, p. 37919 - 37929 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Eosinophilic esophagitis: A clinicopathological review

Philpott, H., Nandurkar, S., Thien, F., Gibson, P. R. & Royce, S. G., 2015, In : Pharmacology and Therapeutics. 146, p. 12 - 22 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Erratum: The pharmacokinetics and pharmacodynamics of severe aldicarb toxicity after overdose (Clinical Toxicology (2015) (1-3))

Michael, A. P., Mostafa, A., Cooper, J. M., Grice, J. E., Roberts, M. S. & Isbister, G. K., 9 Aug 2015, In : Clinical Toxicology. 53, 7, p. 788 1 p.

Research output: Contribution to journalComment / DebateOtherpeer-review

Evidence that Ly6C(hi) monocytes are protective in acute ischemic stroke by promoting M2 macrophage polarization

Chu, H. X., Broughton, B. R. S., Kim, H. H. A., Lee, S. S., Drummond, G. R. & Sobey, C. G., 2015, In : Stroke. 46, 7, p. 1929 - 1937 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Fatty acid-binding proteins 1 and 2 differentially modulate the activation of peroxisome proliferator-activated receptor alpha in a ligand-selective manner

Hughes, M. L. R., Liu, B., Halls, M. L., Wagstaff, K. M., Patil, R., Velkov, T., Jans, D. A., Bunnett, N. W., Scanlon, M. & Porter, C. J., 2015, In : Journal of Biological Chemistry. 290, 22, p. 13895 - 13906 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Ghrelin-related peptides exert protective effects in the cerebral circulation of male mice through a nonclassical ghrelin receptor(s)

Ku, J., Andrews, Z. B., Barsby, T., Reichenbach, A., Lemus, M. B., Drummond, G. R., Sleeman, M., Spencer, S. J., Sobey, C. G. & Miller, A. A., 2015, In : Endocrinology. 156, 1, p. 280 - 290 11 p.

Research output: Contribution to journalArticleResearchpeer-review

GPCR-mediated EGF receptor transactivation regulates TRPV4 action in the vasculature

Saifeddine, M., El-Daly, M., Mihara, K., Bunnett, N. W., McIntyre, P., Altier, C., Hollenberg, M. D. & Ramachandran, R., 2015, In : British Journal of Pharmacology. 172, 10, p. 2493-2506 14 p.

Research output: Contribution to journalArticleResearchpeer-review

GPCR structure, function, drug discovery and crystallography: report from Academia-Industry International Conference (UK Royal Society) Chicheley Hall, 1-2 September 2014

Heifetz, A., Schertler, G. F. X., Seifert, R., Tate, C. G., Sexton, P. M., Gurevich, V. V., Fourmy, D., Cherezov, V., Marshall, F., Storer, R. I., Moraes, I., Tikhonova, I., Tautermann, C., Hunt, P., Ceska, T., Hodgson, S., Bodkin, M., Singh, S., Law, R. & Biggin, P., 22 Aug 2015, In : Naunyn-Schmiedeberg's Archives of Pharmacology. 388, 8, p. 883-903 21 p., 1111.

Research output: Contribution to journalArticleOther

Open Access

G protein-coupled receptors: dynamic machines for signaling pain and itch

Geppetti, P., Veldhuis, N. A., Lieu, T. & Bunnett, N. W., 2015, In : Neuron. 88, 4, p. 635-649 15 p.

Research output: Contribution to journalArticleResearchpeer-review

Hydrogen sulfide treatment reduces blood pressure and oxidative stress in angiotensin II-induced hypertensive mice

Al-Magableh, M. R., Harper, B. K. & Hart, J. L., 2015, In : Hypertension Research. 38, 1, p. 13 - 20 8 p.

Research output: Contribution to journalArticleResearchpeer-review

IgG and EoE: Too soon for a paradigm shift away from IgE

Philpott, H., Royce, S. G., Nandurkar, S., Thien, F. C. K. & Gibson, P. R., 2015, In : Gastroenterology. 148, 2, p. 453 - 454 2 p.

Research output: Contribution to journalLetterOther

Inflammation-induced abnormalities in the subcellular localization and trafficking of the neurokinin 1 receptor in the enteric nervous system

Poole, D. P., Lieu, T. M., Pelayo, J-C., Eriksson, E. M. Y., Veldhuis, N. A. & Bunnett, N. W., 2015, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 309, 4, p. G248-G259 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Label-free (XIC) quantification of venom procoagulant and neurotoxin expression in related australian elapid snakes gives insight into venom toxicity evolution

Skejic, J., Steer, D. L., Dunstan, N. & Hodgson, W. C., 2015, In : Journal of Proteome Research. 14, 11, p. 4896 - 4906 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Lipopolysaccharide does not alter small airway reactivity in mouse lung slices

Donovan, C., Royce, S. G., Vlahos, R. & Bourke, J. E., 2015, In : PLoS ONE. 10, 3, 16 p., e0122069.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Mesenchymal stem cells and serelaxin synergistically abrogate established airway fibrosis in an experimental model of chronic allergic airways disease

Royce, S. G., Shen, M., Patel, K. P., Huuskes, B., Ricardo, S. D. & Samuel, C. S., 2015, In : Stem Cell Research. 15, 3, p. 495 - 505 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Molecular insights into metabotropic glutamate receptor allosteric modulations

Gregory, K. J. & Conn, P. J., 1 Jul 2015, In : Molecular Pharmacology. 88, 1, p. 188-202 15 p.

Research output: Contribution to journalShort SurveyResearchpeer-review

Molecular mechanism of action of triazolobenzodiazepinone agonists of the type 1 cholecystokinin receptor. Possible cooperativity across the receptor homodimeric complex

Desai, A. J., Lam, P. C. H., Orry, A., Abagyan, R., Christopoulos, A., Sexton, P. & Miller, L. J., 2015, In : Journal of Medicinal Chemistry. 58, 24, p. 9562-9577 16 p.

Research output: Contribution to journalArticleResearchpeer-review

Motor and behavioral phenotype in conditional mutants with targeted ablation of cortical D1 dopamine receptor-expressing cells

Jiang, L., O'Leary, C., Kim, H. H. A., Parish, C. L., Massalas, J. S., Waddington, J. L., Ehrlich, M. E., Schutz, G. M., Gantois, I., Lawrence, A. J. & Drago, J., 2015, In : Neurobiology of Disease. 76, p. 137 - 158 22 p.

Research output: Contribution to journalArticleResearchpeer-review

MouseMove: an open source program for semi-automated analysis of movement and cognitive testing in rodents

Samson, A. L., Ju, L., Kim, H. A., Zhang, S., Lee, J. A. A., Sturgeon, S. A., Sobey, C. G., Jackson, S. & Schoenwaelder, S. M., 2015, In : Scientific Reports. 5, (Art. No: 16171), p. 1 - 11 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Neutrophil elastase activates protease-activated receptor-2 (PAR2) and transient receptor potential vanilloid 4 (TRPV4) to cause inflammation and pain

Zhao, P., Lieu, T. M., Barlow, N., Sostegni, S., Haerteis, S., Korbmacher, C., Liedtke, W., Jimenez-Vargas, N. N., Vanner, S. & Bunnett, N. W., 2015, In : Journal of Biological Chemistry. 290, 22, p. 13875 - 13887 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Nitroxyl: a vasodilator of human vessels that is not susceptible to tolerance

Andrews, K. L., Lumsden, N. G., Farry, J., Jefferis, A-M., Kemp-Harper, B. K. & Chin-Dusting, J. P. F., 2015, In : Clinical Science. 129, 2, p. 179 - 187 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Nontypeable Haemophilus influenzae induces sustained lung oxidative stress and protease expression

King, P. T., Sharma, R., O'Sullivan, K., Selemidis, S., Lim, S., Radhakrishna, N., Lo, C. Y-W., Prasad, J., Callaghan, J. M., McLaughlin, P., Farmer, M., Steinfort, D. P., Jennings, B. R., Ngui, J., Broughton, B. R. S., Thomas, B., Essilfie, A-T., Hickey, M. J., Holmes, P., Hansbro, P. M. & 2 othersBardin, P. G. & Holdsworth, S. R., 2015, In : PLoS ONE. 10, 3 (Art. No.: e0120371), p. 1 - 17 17 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Novel allosteric modulators of G protein-coupled receptors

Gentry, P. R., Sexton, P. M. & Christopoulos, A., 2015, In : Journal of Biological Chemistry. 290, 32, p. 19478-19488 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Novel GPCR paradigms at the μ-opioid receptor

Thompson, G. L., Kelly, E., Christopoulos, A. & Canals, M., 2015, In : British Journal of Pharmacology. 172, 2, p. 287-296 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Nox1 upregulates the function of vascular T-type calcium channels following chronic nitric oxide deficit

Howitt, L., Matthaei, K. I., Drummond, G. R. & Hill, C. E., 2015, In : Pflugers Archiv-European Journal of Physiology. 467, 4, p. 727 - 735 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Obligatory role for B cells in the development of angiotensin II-dependent hypertension

Chan, C. T-L., Sobey, C. G., Lieu, M., Ferens, D. M., Kett, M. M., Diep, H., Kim, H. H. A., Krishnan, S. M., Lewis, C. V., Salimova, E., Tipping, P. G., Vinh, A., Samuel, C. S., Peter, K., Guzik, T. J., Kyaw, T. S., Toh, B-H., Bobik, A. & Drummond, G. R., 2015, In : Hypertension. 66, 5, p. 1023 - 1033 11 p.

Research output: Contribution to journalArticleResearchpeer-review

P2Y1 receptor activation of the TRPV4 ion channel enhances purinergic signaling in satellite glial cells

Rajasekhar, P., Poole, D. P., Liedtke, W., Bunnett, N. W. & Veldhuis, N. A., 2015, In : Journal of Biological Chemistry. 290, 48, p. 29051-29062 12 p.

Research output: Contribution to journalArticleResearchpeer-review

PcTx1 affords neuroprotection in a conscious model of stroke in hypertensive rats via selective inhibition of ASIC1a

McCarthy, C. A., Rash, L. D., Chassagnon, I. R., King, G. F. & Widdop, R. E., 2015, In : Neuropharmacology. 99, (Art. No: 5986), p. 650 - 657 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Pin1 promotes neuronal death in stroke by stabilizing Notch intracellular domain

Baik, S-H., Fane, M., Park, J. H., Cheng, Y-L., Fann, D. Y-W., Yun, U. J., Choi, Y., Park, J-S., Chai, B. H., Park, J. S., Back, S. H., Jeong, J. I., Jang, Y. J., Bahn, G., Lee, J-Y., Li, Y., Sobey, C. G., Uchida, T., Park, J. H., Kim, H. T. & 3 othersTang, S-C., Arumugam, T. V. & Jo, D-G., 2015, In : Annals of Neurology. 77, 3, p. 504 - 516 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Proof of concept study for designed multiple ligands targeting the dopamine D2, serotonin 5-HT2A, and muscarinic M1 acetylcholine receptors

Szabo, M., Lim, H. D., Klein Herenbrink, C., Christopoulos, A., Lane, J. R. D. & Capuano, B., 2015, In : Journal of Medicinal Chemistry. 58, 3, p. 1550 - 1555 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Quantification and potential functions of endogenous agonists of transient receptor potential channels in patients with irritable bowel syndrome

Cenac, N., Bautzova, T., Le Faouder, P., Veldhuis, N. A., Poole, D. P., Rolland, C., Bertrand, J., Liedtke, W., Dubourdeau, M., Bertrand-Michel, J., Zecchi, L., Stanghellini, V., Bunnett, N. W., Barbara, G. & Vergnolle, N., 2015, In : Gastroenterology. 149, 2, p. 433-444 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Receptor expression modulates calcium-sensing receptor mediated intracellular Ca2+ mobilization

Brennan, S. C., Mun, H., Leach, K., Kuchel, P. W., Christopoulos, A. & Conigrave, A., 2015, In : Endocrinology. 156, 4, p. 1330 - 1342 13 p.

Research output: Contribution to journalArticleResearchpeer-review