Research Output

2016

Neonatal pneumococcal colonisation caused by Influenza A infection alters lung function in adult mice

FitzPatrick, M., Royce, S. G., Langenbach, S., McQualter, J., Reading, P. C., Wijburg, O., Anderson, G. P., Stewart, A., Bourke, J. & Bozinovski, S., 2016, In : Scientific Reports. 6, p. 1 - 12 12 p., 22751.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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4 Citations (Scopus)

Neuromuscular Effects of Common Krait (Bungarus caeruleus) Envenoming in Sri Lanka

Silva, A., Maduwage, K., Sedgwick, M., Pilapitiya, S., Weerawansa, P., Dahanayaka, N. J., Buckley, N. A., Johnston, C., Siribaddana, S. & Isbister, G. K., 1 Feb 2016, In : PLoS Neglected Tropical Diseases. 10, 2, 18 p., e0004368.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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22 Citations (Scopus)

Neurotensin-induced miR-133α expression regulates neurotensin receptor 1 recycling through its downstream target aftiphilin

Law, I. K. M., Jensen, D., Bunnett, N. W. & Pothoulakis, C., 23 Feb 2016, In : Scientific Reports. 6, 14 p., 22195.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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2 Citations (Scopus)

Neurotoxicity in Russells viper (Daboia russelii) envenoming in Sri Lanka: A clinical and neurophysiological study

Silva, A., Maduwage, K., Sedgwick, M., Pilapitiya, S., Weerawansa, P., Dahanayaka, N. J., Buckley, N. A., Siribaddana, S. & Isbister, G. K., 27 May 2016, In : Clinical Toxicology. 54, 5, p. 411-419 9 p.

Research output: Contribution to journalArticleResearchpeer-review

21 Citations (Scopus)

Nitroxyl (HNO) reduces endothelial and monocyte activation and promotes M2 macrophage polarization

Andrews, K. L., Sampson, A. K., Irvine, J. C., Shihata, W. A., Michell, D. L., Lumsden, N. G., Lim, C., Huet, O., Drummond, G. R., Kemp-Harper, B. K. & Chin-Dusting, J. P. F., 2016, In : Clinical Science. 130, 18, p. 1629-1640 12 p.

Research output: Contribution to journalArticleResearchpeer-review

10 Citations (Scopus)

Novel fused arylpyrimidinone based allosteric modulators of the M1 muscarinic acetylcholine receptor

Mistry, S. N., Lim, H., Jorg, M., Capuano, B., Christopoulos, A., Lane, J. R. & Scammells, P. J., 18 May 2016, In : ACS Chemical Neuroscience. 7, 5, p. 647-661 15 p.

Research output: Contribution to journalArticleResearchpeer-review

9 Citations (Scopus)

Novel irreversible agonists acting at the A1 adenosine receptor

Jorg, M., Glukhova, A., Abdul Ridha, A., Vecchio, E. A., Nguyen, A., Sexton, P., White, P., May, L., Christopoulos, A. & Scammells, P., 22 Dec 2016, In : Journal of Medicinal Chemistry. 59, 24, p. 11182-11194 13 p.

Research output: Contribution to journalArticleResearchpeer-review

9 Citations (Scopus)

N-terminal domain of Bothrops asper Myotoxin II Enhances the Activity of Endothelin Converting Enzyme-1 and Neprilysin

Smith, A. I., Rajapakse, N. W., Kleifeld, O., Lomonte, B., Sikanyika, N. L., Spicer, A. J., Hodgson, W. C., Conroy, P. J., Small, D. H., Kaye, D. M., Parkington, H. C., Whisstock, J. C. & Kuruppu, S. M. S., 2 Mar 2016, In : Scientific Reports. 6, 10 p., 22413.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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8 Citations (Scopus)

Origin of Aberrant Blood Pressure and Sympathetic Regulation in Diet-Induced Obesity

Lim, K., Barzel, B., Burke, S. L., Armitage, J. A. & Head, G. A., 1 Aug 2016, In : Hypertension. 68, 2, p. 491-500 10 p.

Research output: Contribution to journalArticleResearchpeer-review

14 Citations (Scopus)

Orthosteric, allosteric and biased signalling at the relaxin-3 receptor RXFP3

Kocan, M., Ang, S. Y. & Summers, R. J., 2016, In : Neurochemical Research. 41, 3, p. 610-619 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Plasma membrane localization of the μ-opioid receptor controls spatiotemporal signaling

Halls, M., Yeatman, H. R., Nowell, C. J., Thompson, G. L., Gondin, A. B., Civciristov, S., Bunnett, N. W., Lambert, N. A., Poole, D. P. & Canals, M., 9 Feb 2016, In : Science Signaling. 9, 414, p. 1-13 13 p., ra16.

Research output: Contribution to journalArticleResearchpeer-review

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40 Citations (Scopus)
Open Access
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9 Citations (Scopus)

Prediction of loops in G protein-coupled receptor homology models: effect of imprecise surroundings and constraints

Arora, B., Coudrat, T., Wootten, D., Christopoulos, A., Noronha, S. B. & Sexton, P. M., 25 Apr 2016, In : Journal of Chemical Information and Modeling. 56, 4, p. 671-686 16 p.

Research output: Contribution to journalArticleResearchpeer-review

5 Citations (Scopus)

Prognostic and mechanistic potential of progesterone sulfates in intrahepatic cholestasis of pregnancy and pruritus gravidarum

Abu-Hayyeh, S., Ovadia, C., Lieu, T., Jensen, D. D., Chambers, J., Dixon, P. H., Lovgren-Sandblom, A., Bolier, R., Tolenaars, D., Kremer, A. E., Syngelaki, A., Noori, M., Williams, D., Marin, J. J. G., Monte, M. J., Nicolaides, K. H., Beuers, U. H. W., Oude-Elferink, R., Seed, P. T., Chappell, L. & 3 others, Marschall, H-U., Bunnett, N. W. & Williamson, C., 2016, In : Hepatology. 63, 4, p. 1287-1298 12 p.

Research output: Contribution to journalArticleResearchpeer-review

38 Citations (Scopus)

Promise and limitations of relaxin-based therapies in chronic fibrotic lung diseases

Royce, S. G., Bathgate, R. A. D. & Samuel, C. S., 1 Dec 2016, In : American Journal of Respiratory and Critical Care Medicine. 194, 11, p. 1434-1435 2 p.

Research output: Contribution to journalLetterOtherpeer-review

1 Citation (Scopus)

Proposed mode of binding and action of positive allosteric modulators at opioid receptors

Shang, Y., Yeatman, H. R., Provasi, D., Alt, A., Christopoulos, A., Canals, M. & Filizola, M., 20 May 2016, In : ACS Chemical Biology. 11, 5, p. 1220-1229 10 p.

Research output: Contribution to journalArticleResearchpeer-review

28 Citations (Scopus)

Protein kinase D and Gβγ subunits mediate agonist-evoked translocation of protease-activated receptor-2 from the golgi apparatus to the plasma membrane

Jensen, D. D., Zhao, P., Jimenez-Vargas, N. N., Lieu, T., Gerges, M., Yeatman, H. R., Canals, M., Vanner, S. J., Poole, D. P. & Bunnett, N. W., 20 May 2016, In : The Journal of Biological Chemistry. 291, 21, p. 11285-11299 15 p.

Research output: Contribution to journalArticleResearchpeer-review

9 Citations (Scopus)

Qualitative and Quantitative Analysis of Histone Deacetylases in Kidney Tissue Sections

Ververis, K., Marzully, S. P., Samuel, C. S., Hewitson, T. D. & Karagiannis, T. C., 2016, Kidney Research: Experimental Protocols. Hewitson, T. D., Smith, E. R. & Holt, S. G. (eds.). 2nd ed. New York NY USA: Humana Press, p. 279-289 11 p. (Methods in Molecular Biology: Springer Protocols; vol. 1397).

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Otherpeer-review

2 Citations (Scopus)

Quantification of adenosine A1 receptor biased agonism: Implications for drug discovery

Baltos, J-A., Gregory, K. J., White, P. J., Sexton, P. M., Christopoulos, A. & May, L. T., 1 Jan 2016, In : Biochemical Pharmacology. 99, p. 101-112 12 p.

Research output: Contribution to journalArticleResearchpeer-review

29 Citations (Scopus)

Reassessing the role of the NLRP3 inflammasome during pathogenic influenza A virus infection via temporal inhibition

Tate, M. D., Ong, J. DH., Dowling, J. K., McAuley, J. L., Robertson, A. B., Latz, E., Drummond, G. R., Cooper, M. A., Hertzog, P. J. & Mansell, A., 10 Jun 2016, In : Scientific Reports. 6, 8 p., 27912.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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59 Citations (Scopus)

Relationships between adult asthma and oxidative stress markers and pH in exhaled breath condensate: A systematic review

Aldakheel, F. M., Thomas, P. S., Bourke, J. E., Matheson, M. C., Dharmage, S. C. & Lowe, A. J., Jun 2016, In : Allergy. 71, 6, p. 741-757 17 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

28 Citations (Scopus)

Role of chemokine RANTES in the regulation of perivascular inflammation, T-cell accumulation, and vascular dysfunction in hypertension

Mikolajczyk, T. P., Nosalski, R., Szczepaniak, P., Budzyn, K., Osmenda, G., Skiba, D., Sagan, A., Wu, J., Vinh, A., Marvar, P. J., Guzik, B., Podolec, J., Drummond, G., Lob, H. E., Harrison, D. G. & Guzik, T. J., May 2016, In : The FASEB Journal. 30, 5, p. 1987-1999 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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70 Citations (Scopus)

Role of the second extracellular loop of the adenosine A1 receptor on allosteric modulator binding, signaling, and cooperativity

Nguyen, A. T. N., Vecchio, E. A., Thomas, T., Nguyen, T. D., Aurelio, L., Scammells, P. J., White, P. J., Sexton, P. M., Gregory, K. J., May, L. T. & Christopoulos, A., 1 Dec 2016, In : Molecular Pharmacology. 90, 6, p. 715-725 11 p.

Research output: Contribution to journalArticleResearchpeer-review

25 Citations (Scopus)

Serelaxin elicits bronchodilation and enhances β-Adrenoceptor-mediated airway relaxation

Lam, M., Royce, S. G., Donovan, C., Jelinic, M., Parry, L. J., Samuel, C. S. & Bourke, J. E., 27 Oct 2016, In : Frontiers in Pharmacology. 7, 406, 18 p., 406.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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7 Citations (Scopus)

Serelaxin improves the therapeutic efficacy of RXFP1-expressing human amnion epithelial cells in experimental allergic airway disease

Royce, S. G., Tominaga, A. M., Shen, M., Patel, K. P., Huuskes, B., Lim, R., Ricardo, S. D. & Samuel, C. S., 2016, In : Clinical Science. 130, 23, p. 2151-2165 15 p.

Research output: Contribution to journalArticleResearchpeer-review

7 Citations (Scopus)

Stimulating the Activity of Amyloid-Beta Degrading Enzymes: A Novel Approach for the Therapeutic Manipulation of Amyloid-Beta Levels

Kuruppu, S., Rajapakse, N. W., Spicer, A. J., Parkington, H. C. & Smith, A. I., 4 Oct 2016, In : Journal of Alzheimer's Disease. 54, 3, p. 891-895 5 p.

Research output: Contribution to journalArticleResearchpeer-review

6 Citations (Scopus)

Structure-activity analysis of biased agonism at the human adenosine A3 receptor

Baltos, J-A., Paoletta, S., Nguyen, A. T. N., Gregory, K. J., Tosh, D. K., Christopoulos, A., Jacobson, K. A. & May, L. T., 1 Jul 2016, In : Molecular Pharmacology. 90, 1, p. 12-22 11 p.

Research output: Contribution to journalArticleResearchpeer-review

24 Citations (Scopus)

Systematic analysis of factors influencing observations of biased agonism at the mu-opioid receptor

Thompson, G. L., Lane, J. R., Coudrat, T., Sexton, P. M., Christopoulos, A. & Canals, M., 1 Aug 2016, In : Biochemical Pharmacology. 113, p. 70-87 18 p.

Research output: Contribution to journalArticleResearchpeer-review

34 Citations (Scopus)

Targeting the IL-33/IL-13 axis for respiratory viral infections

Donovan, C., Bourke, J. E. & Vlahos, R., Apr 2016, In : Trends in Pharmacological Sciences. 37, 4, p. 252-261 10 p.

Research output: Contribution to journalArticleOtherpeer-review

17 Citations (Scopus)
Open Access
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18 Citations (Scopus)

The Coagulant Factor Xa Induces Protease-Activated Receptor-1 and Annexin A2–Dependent Airway Smooth Muscle Cytokine Production and Cell Proliferation

Schuliga, M., Royce, S. G., Langenbach, S., Berhan, A., Harris, T., Keenan, C. R. & Stewart, A. G., 2016, In : American Journal of Respiratory Cell and Molecular Biology. 54, 2, p. 200-209 10 p.

Research output: Contribution to journalArticleResearchpeer-review

9 Citations (Scopus)

The complexity of signalling mediated by the glucagon-like peptide-1 receptor

Fletcher, M. M., Halls, M. L., Christopoulos, A., Sexton, P. M. & Wootten, D., 15 Apr 2016, In : Biochemical Society Transactions. 44, 2, p. 582-588 7 p.

Research output: Contribution to journalArticleResearchpeer-review

7 Citations (Scopus)

The C-terminus of the B-chain of human insulin-like peptide 5 is critical for cognate RXFP4 receptor activity

Patil, N. A., Bathgate, R. A. D., Kocan, M., Ang, S. Y., Tailhades, J., Separovic, F., Summers, R., Grosse, J., Hughes, R. A., Wade, J. D. & Hossain, M. A., 1 Apr 2016, In : Amino Acids. 48, 4, p. 987-992 6 p.

Research output: Contribution to journalArticleResearchpeer-review

8 Citations (Scopus)

The effects of rilmenidine and perindopril on arousal blood pressure during 24 hour recordings in SHR

Lim, K., Jackson, K. L., Burke, S. L. & Head, G. A., 21 Dec 2016, In : PLoS ONE. 11, 12, 19 p., e0168425.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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1 Citation (Scopus)

The extracellular surface of the GLP-1 receptor is a molecular trigger for biased agonism

Wootten, D., Reynolds, C. A., Smith, K. J., Mobarec, J. C., Koole, C., Savage, E. E., Pabreja, K., Simms, J., Sridhar, R., Furness, S. G. B., Liu, M., Thompson, P. E., Miller, L. J., Christopoulos, A. & Sexton, P. M., 16 Jun 2016, In : Cell. 165, 7, p. 1632-1643 12 p.

Research output: Contribution to journalArticleResearchpeer-review

64 Citations (Scopus)

The Helix-Loop-Helix Protein ID2 Governs NK Cell Fate by Tuning Their Sensitivity to Interleukin-15

Delconte, R. B., Shi, W., Sathe, P., Ushiki, T., Seillet, C., Minnich, M., Kolesnik, T. B., Rankin, L. C., Mielke, L. A., Zhang, J-G., Busslinger, M., Smyth, M. J., Hutchinson, D. S., Nutt, S. L., Nicholson, S. E., Alexander, W. S., Corcoran, L. M., Vivier, E., Belz, G. T., Carotta, S. & 1 others, Huntington, N. D., 19 Jan 2016, In : Immunity. 44, 1, p. 103-115 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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56 Citations (Scopus)

The hybrid molecule, VCP746, is a potent adenosine A2B receptor agonist that stimulates anti-fibrotic signalling

Vecchio, L., Chuo, C. H., Baltos, J-A., Ford, L., Scammells, P. J., Wang, B. H., Christopoulos, A., White, P. J. & May, L. T., 1 Oct 2016, In : Biochemical Pharmacology. 117, p. 46-56 11 p.

Research output: Contribution to journalArticleResearchpeer-review

15 Citations (Scopus)

Therapeutic Potential of Nitroxyl (HNO) Donors in the Management of Acute Decompensated Heart Failure

Kemp-Harper, B. K., Horowitz, J. D. & Ritchie, R. H., 1 Sep 2016, In : Drugs. 76, 14, p. 1337-1348 12 p.

Research output: Contribution to journalArticleResearchpeer-review

17 Citations (Scopus)

The role of kinetic context in apparent biased agonism at GPCRs

Herenbrink, C. K., Sykes, D. A., Donthamsetti, P., Canals, M., Coudrat, T., Shonberg, J., Scammells, P. J., Capuano, B., Sexton, P. M., Charlton, S. J., Javitch, J. A., Christopoulos, A. & Lane, J. R., 24 Feb 2016, In : Nature Communications. 7, 14 p., 10842.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
144 Citations (Scopus)

The Snake with the Scorpion’s Sting: Novel Three-Finger Toxin Sodium Channel Activators from the Venom of the Long-Glanded Blue Coral Snake (Calliophis bivirgatus)

Yang, D. C., Deuis, J. R., Dashevsky, D., Dobson, J., Jackson, T. N. W., Brust, A., Xie, B., Koludarov, I., Debono, J., Hendrikx, I., Hodgson, W. C., Josh, P., Nouwens, A., Baillie, G. J., Bruxner, T. JC., Alewood, P. F., Lim, K. K. P., Frank, N., Vetter, I. & Fry, B. G., 18 Oct 2016, In : Toxins. 8, 10, 21 p., 303.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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The β2-adrenoceptor activates a positive cAMP-calcium feedforward loop to drive breast cancer cell invasion

Pon, C., Lane, J. R. D., Sloan, E. K. & Halls, M., 2016, In : The FASEB Journal. 30, 3, p. 1144-1154 11 p.

Research output: Contribution to journalArticleResearchpeer-review

24 Citations (Scopus)

Towards a structural understanding of allosteric drugs at the human calcium-sensing receptor

Leach, K., Gregory, K., Kufareva, I., Khajehali, E., Cook, A. E., Abagyan, R., Conigrave, A. D., Sexton, P. M. & Christopoulos, A., 1 May 2016, In : Cell Research. 26, 5, p. 574-592 19 p.

Research output: Contribution to journalArticleResearchpeer-review

41 Citations (Scopus)

Use of cysteine trapping to map spatial approximations between residues contributing to the helix N-capping motif of secretin and distinct residues within each of the extracellular loops of its receptor

Dong, M., Lam, P. C. H., Orry, A., Sexton, P. M., Christopoulos, A., Abagyan, R. & Miller, L. J., 4 Mar 2016, In : The Journal of Biological Chemistry. 291, 10, p. 5172-5184 13 p.

Research output: Contribution to journalArticleResearchpeer-review

6 Citations (Scopus)

Vascular biology and atherosclerosis of cerebral vessles

Chrissobolis, S. & Sobey, C. G., 2016, Stroke: Pathophysiology, Diagnosis and Management. Grotta, J. C., Albers, G. W., Broderick, J. P., Kasner, S. E., Lo, E. H., Mendelow, A. D., Sacco, R. L. & Wong, L. O. K. S. (eds.). 6th ed. Canada: Elsevier, p. 3-12 10 p.

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Otherpeer-review

12 Citations (Scopus)

β2-adrenoceptors on tumor cells play a critical role in stress-enhanced metastasis in a mouse model of breast cancer

Chang, A., Le, C. P., Walker, A. K., Creed, S. J., Pon, C. K., Albold, S., Carroll, D., Halls, M. L., Lane, J. R., Riedel, B., Ferrari, D. & Sloan, E. K., 1 Oct 2016, In : Brain, Behavior, and Immunity. 57, p. 106-115 10 p.

Research output: Contribution to journalArticleResearchpeer-review

25 Citations (Scopus)

β-arrestin-biased agonists of the GLP-1 receptor from β-amino acid residue incorporation into GLP-1 analogues

Hager, M. V., Johnson, L. M., Wootten, D., Sexton, P. M. & Gellman, S. H., 16 Nov 2016, In : Journal of the American Chemical Society. 138, 45, p. 14970-14979 10 p.

Research output: Contribution to journalArticleResearchpeer-review

32 Citations (Scopus)
2015

Activin and NADPH-oxidase in preeclampsia: insights from in vitro and murine studies

Lim, R., Acharya, R., Delpachitra, P., Hobson, S., Sobey, C. G., Drummond, G. R. & Wallace, E. M., 1 Jan 2015, In : American Journal of Obstetrics and Gynecology. 212, 1, p. 86.e1 - 86.e12 12 p.

Research output: Contribution to journalArticleResearchpeer-review

36 Citations (Scopus)

Allosteric modulation of chemokine receptors

Tschammer, N., Christopoulos, A. & Kenakin, T., 2015, Chemokines: Chemokines and Their Receptors in Drug Discovery. Tschammer, N. (ed.). Cham Switzerland: Springer, p. 87-117 31 p.

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Researchpeer-review

3 Citations (Scopus)

Alteration of airway reactivity and reduction of ryanodine receptor expression by cigarette smoke in mice

Donovan, C., Seow, H. J., Royce, S. G., Bourke, J. E. & Vlahos, R., 2015, In : American Journal of Respiratory Cell and Molecular Biology. 53, 4, p. 471 - 478 8 p.

Research output: Contribution to journalArticleResearchpeer-review

9 Citations (Scopus)