Research Output 1986 2019

2016

The C-terminus of the B-chain of human insulin-like peptide 5 is critical for cognate RXFP4 receptor activity

Patil, N. A., Bathgate, R. A. D., Kocan, M., Ang, S. Y., Tailhades, J., Separovic, F., Summers, R., Grosse, J., Hughes, R. A., Wade, J. D. & Hossain, M. A., 1 Apr 2016, In : Amino Acids. 48, 4, p. 987-992 6 p.

Research output: Contribution to journalArticleResearchpeer-review

The effects of rilmenidine and perindopril on arousal blood pressure during 24 hour recordings in SHR

Lim, K., Jackson, K. L., Burke, S. L. & Head, G. A., 21 Dec 2016, In : PLoS ONE. 11, 12, 19 p., e0168425.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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The extracellular surface of the GLP-1 receptor is a molecular trigger for biased agonism

Wootten, D., Reynolds, C. A., Smith, K. J., Mobarec, J. C., Koole, C., Savage, E. E., Pabreja, K., Simms, J., Sridhar, R., Furness, S. G. B., Liu, M., Thompson, P. E., Miller, L. J., Christopoulos, A. & Sexton, P. M., 16 Jun 2016, In : Cell. 165, 7, p. 1632-1643 12 p.

Research output: Contribution to journalArticleResearchpeer-review

The Helix-Loop-Helix Protein ID2 Governs NK Cell Fate by Tuning Their Sensitivity to Interleukin-15

Delconte, R. B., Shi, W., Sathe, P., Ushiki, T., Seillet, C., Minnich, M., Kolesnik, T. B., Rankin, L. C., Mielke, L. A., Zhang, J-G., Busslinger, M., Smyth, M. J., Hutchinson, D. S., Nutt, S. L., Nicholson, S. E., Alexander, W. S., Corcoran, L. M., Vivier, E., Belz, G. T., Carotta, S. & 1 othersHuntington, N. D., 19 Jan 2016, In : Immunity. 44, 1, p. 103-115 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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The hybrid molecule, VCP746, is a potent adenosine A2B receptor agonist that stimulates anti-fibrotic signalling

Vecchio, L., Chuo, C. H., Baltos, J-A., Ford, L., Scammells, P. J., Wang, B. H., Christopoulos, A., White, P. J. & May, L. T., 1 Oct 2016, In : Biochemical Pharmacology. 117, p. 46-56 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Therapeutic Potential of Nitroxyl (HNO) Donors in the Management of Acute Decompensated Heart Failure

Kemp-Harper, B. K., Horowitz, J. D. & Ritchie, R. H., 1 Sep 2016, In : Drugs. 76, 14, p. 1337-1348 12 p.

Research output: Contribution to journalArticleResearchpeer-review

The role of kinetic context in apparent biased agonism at GPCRs

Herenbrink, C. K., Sykes, D. A., Donthamsetti, P., Canals, M., Coudrat, T., Shonberg, J., Scammells, P. J., Capuano, B., Sexton, P. M., Charlton, S. J., Javitch, J. A., Christopoulos, A. & Lane, J. R., 24 Feb 2016, In : Nature Communications. 7, 14 p., 10842.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

The Snake with the Scorpion’s Sting: Novel Three-Finger Toxin Sodium Channel Activators from the Venom of the Long-Glanded Blue Coral Snake (Calliophis bivirgatus)

Yang, D. C., Deuis, J. R., Dashevsky, D., Dobson, J., Jackson, T. N. W., Brust, A., Xie, B., Koludarov, I., Debono, J., Hendrikx, I., Hodgson, W. C., Josh, P., Nouwens, A., Baillie, G. J., Bruxner, T. JC., Alewood, P. F., Lim, K. K. P., Frank, N., Vetter, I. & Fry, B. G., 18 Oct 2016, In : Toxins. 8, 10, 21 p., 303.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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The β2-adrenoceptor activates a positive cAMP-calcium feedforward loop to drive breast cancer cell invasion

Pon, C., Lane, J. R. D., Sloan, E. K. & Halls, M., 2016, In : FASEB Journal. 30, 3, p. 1144-1154 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Towards a structural understanding of allosteric drugs at the human calcium-sensing receptor

Leach, K., Gregory, K., Kufareva, I., Khajehali, E., Cook, A. E., Abagyan, R., Conigrave, A. D., Sexton, P. M. & Christopoulos, A., 1 May 2016, In : Cell Research. 26, 5, p. 574-592 19 p.

Research output: Contribution to journalArticleResearchpeer-review

Use of cysteine trapping to map spatial approximations between residues contributing to the helix N-capping motif of secretin and distinct residues within each of the extracellular loops of its receptor

Dong, M., Lam, P. C. H., Orry, A., Sexton, P. M., Christopoulos, A., Abagyan, R. & Miller, L. J., 4 Mar 2016, In : Journal of Biological Chemistry. 291, 10, p. 5172-5184 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Vascular biology and atherosclerosis of cerebral vessles

Chrissobolis, S. & Sobey, C. G., 2016, Stroke: Pathophysiology, Diagnosis and Management. Grotta, J. C., Albers, G. W., Broderick, J. P., Kasner, S. E., Lo, E. H., Mendelow, A. D., Sacco, R. L. & Wong, L. O. K. S. (eds.). 6th ed. Canada: Elsevier, p. 3-12 10 p.

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Otherpeer-review

β2-adrenoceptors on tumor cells play a critical role in stress-enhanced metastasis in a mouse model of breast cancer

Chang, A., Le, C. P., Walker, A. K., Creed, S. J., Pon, C. K., Albold, S., Carroll, D., Halls, M. L., Lane, J. R., Riedel, B., Ferrari, D. & Sloan, E. K., 1 Oct 2016, In : Brain, Behavior, and Immunity. 57, p. 106-115 10 p.

Research output: Contribution to journalArticleResearchpeer-review

β-arrestin-biased agonists of the GLP-1 receptor from β-amino acid residue incorporation into GLP-1 analogues

Hager, M. V., Johnson, L. M., Wootten, D., Sexton, P. M. & Gellman, S. H., 16 Nov 2016, In : Journal of the American Chemical Society. 138, 45, p. 14970-14979 10 p.

Research output: Contribution to journalArticleResearchpeer-review

2015

Activin and NADPH-oxidase in preeclampsia: insights from in vitro and murine studies

Lim, R., Acharya, R., Delpachitra, P., Hobson, S., Sobey, C. G., Drummond, G. R. & Wallace, E. M., 1 Jan 2015, In : American Journal of Obstetrics and Gynecology. 212, 1, p. 86.e1 - 86.e12 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Allosteric modulation of chemokine receptors

Tschammer, N., Christopoulos, A. & Kenakin, T., 2015, Chemokines: Chemokines and Their Receptors in Drug Discovery. Tschammer, N. (ed.). Cham Switzerland: Springer, p. 87-117 31 p.

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Researchpeer-review

Alteration of airway reactivity and reduction of ryanodine receptor expression by cigarette smoke in mice

Donovan, C., Seow, H. J., Royce, S. G., Bourke, J. E. & Vlahos, R., 2015, In : American Journal of Respiratory Cell and Molecular Biology. 53, 4, p. 471 - 478 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Angiotensis-based peptides as AT2R agonists

Jones, E. S., Wang, Y., Del Borgo, M. P., Denton, K. M., Aguilar, M-I. I. & Widdop, R. E., 2015, The Protective Arm of the Renin-Angiotensin System: Functional Aspects and Therapeutic Implications. Unger, T., Steckelings, U. M. & dos Santos, R. A. S. (eds.). 1st ed. London UK: Elsevier, p. 141 - 147 7 p.

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Otherpeer-review

A novel segmental challenge model for bleomycin-induced pulmonary fibrosis in sheep

Organ, L., Bacci, B., Koumoundouros, E., Barcham, G., Kimpton, W., Nowell, C., Samuel, C. & Snibson, K., 2015, In : Experimental Lung Research. 41, 3, p. 115-134 20 p.

Research output: Contribution to journalArticleResearchpeer-review

A positive allosteric modulator of the adenosine A1 receptor selectively inhibits primary afferent synaptic transmission in a neuropathic pain model

Imlach, W. L., Bhola, R. F., May, L. T., Christopoulos, A. & Christie, M. J., 2015, In : Molecular Pharmacology. 88, 3, p. 460-468 9 p.

Research output: Contribution to journalArticleResearchpeer-review

A structure-activity relationship study of the positive allosteric modulator LY2033298 at the M4 muscarinic acetylcholine receptor

Szabo, M., Huynh, T., Valant, C., Lane, J. R., Sexton, P. M., Christopoulos, A. & Capuano, B., 2015, In : MedChemComm. 6, 11, p. 1998-2003 6 p.

Research output: Contribution to journalArticleResearchpeer-review

AT2R, vascular effects, and blood pressure

Dias Baraldi, D., Jones, E. S., Hilliard, L. M., Del Borgo, M. P., Gaspari, T. A., McCarthy, C. A., Vinh, A., Weungoda, I., Aguilar, M-I. I., Denton, K. M. & Widdop, R. E., 2015, The Protective Arm of the Renin-Angiotensin System: Functional Aspects and Therapeutic Implications. Unger, T., Steckelings, U. M. & dos Santos, R. A. S. (eds.). 1st ed. London UK: Elsevier, p. 49 - 55 7 p.

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Otherpeer-review

beta-Pro7Ang III is a novel highly selective angiotensin II type 2 receptor (AT2R) agonist, which acts as a vasodepressor agent via the AT2R in conscious spontaneously hypertensive rats

Del Borgo, M. P., Wang, Y., Bosnyak, S., Walters, P. E., Spizzo, I., Perlmutter, P., Hilliard, L. M., Denton, K. M., Aguilar, M-I. M., Widdop, R. E. & Jones, E. S., 2015, In : Clinical Science. 129, 6, p. 505 - 513 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Biased agonism and biased allosteric modulation at the CB1 cannabinoid receptors

Khajehali, E., Malone, D. T., Glass, M., Sexton, P., Christopoulos, A. & Leach, K., 2015, In : Molecular Pharmacology. 88, 2, p. 368-379 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Biased agonism of endogenous opioid peptides at the μ-opioid receptor

Thompson, G. L., Lane, J. R. D., Coudrat, T., Sexton, P., Christopoulos, A. & Canals, M., 2015, In : Molecular Pharmacology. 88, 2, p. 335-346 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Biased allosteric modulation at the CaS receptor engendered by structurally diverse calcimimetics

Cook, A. E., Mistry, S. N., Gregory, K. J., Furness, S. G. B., Sexton, P., Scammells, P. J., Conigrave, A., Christopoulos, A. & Leach, K., 2015, In : British Journal of Pharmacology. 172, 1, p. 185 - 200 16 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Chronic administration of the nitroxyl donor 1-nitrosocyclo hexyl acetate limits left ventricular diastolic dysfunction in a mouse model of diabetes mellitus in vivo

Cao, N., Wong, Y. G., Rosli, S., Kiriazis, H., Huynh, K., Qin, C. H., Du, X-J., Kemp-Harper, B. K. & Ritchie, R. H., 2015, In : Circulation: Heart Failure. 8, 3, p. 572 - 581 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Combination therapy of mesenchymal stem cells and serelaxin effectively attenuates renal fibrosis in obstructive nephropathy

Huuskes, B., Wise, A. F., Cox, A. J., Lim, E. X. F., Payne, N. L., Kelly, D. J., Samuel, C. S. & Ricardo, S. D., 2015, In : FASEB Journal. 29, 2, p. 540 - 553 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Danger signals in stroke

Gelderblom, M., Sobey, C. G., Kleinschnitz, C. & Magnus, T., 2015, In : Ageing Research Reviews. 24, Pt. A, p. 77 - 82 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Demonstration of elevated levels of active cathepsin S in dextran sulfate sodium colitis using a new activatable probe

Barlow, N., Nasser, Y., Zhao, P., Sharma, N., Guerrero-Alba, R., Edgington-Mitchell, L. E., Lieu, T., Veldhuis, N. A., Poole, D. P., Conner, J. W., Lindstrom, E., Craig, A. W., Graham, B., Vanner, S. J. & Bunnett, N. W., 2015, In : Neurogastroenterology and Motility. 27, 11, p. 1675-1680 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Detection and quantification of intracellular signaling using FRET-based biosensors and high content imaging

Halls, M. L., Poole, D. P., Ellisdon, A. M., Nowell, C. & Canals, M., 2015, G Protein-Coupled Receptors in Drug Discovery: Methods and Protocols. Filizola, M. (ed.). 2 ed. New York NY USA: Springer, Vol. 1335. p. 131-161 31 p. (Methods in Molecular Biology; vol. 1335, no. 2).

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Otherpeer-review

Open Access
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Development of a highly selective allosteric antagonist radioligand for the type 1 cholecystokinin receptor and elucidation of its molecular basis of binding

Dong, M., Vattelana, A. M., Lam, P. C. H., Orry, A., Abagyan, R., Christopoulos, A., Sexton, P., Haines, D. R. & Miller, L. J., 2015, In : Molecular Pharmacology. 87, 1, p. 130-140 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Dietary sulforaphane in cancer chemoprevention: the role of epigenetic regulation and HDAC inhibition

Tortorella, S., Royce, S. G., Licciardi, P. V. & Karagiannis, T. C., 2015, In : Antioxidants and Redox Signaling. 22, 16, p. 1382 - 1424 43 p.

Research output: Contribution to journalArticleResearchpeer-review

Differential activation of renal sympathetic burst amplitude and frequency during hypoxia, stress and baroreflexes with chronic angiotensin treatment

Lim, K. J., Burke, S. L., Moretti, J-L. & Head, G. A., 2015, In : Experimental Physiology. 100, 10, p. 1132 - 1144 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Discovery, synthesis, and molecular pharmacology of selective positive allosteric modulators of the δ-opioid receptor

Burford, N. T., Livingston, K. E., Canals, M., Ryan, M. R., Budenholzer, L. M. L., Han, Y., Shang, Y., Herbst, J. J., O'Connell, J., Banks, M., Zhang, L., Filizola, M., Bassoni, D. L., Wehrman, T. S., Christopoulos, A., Traynor, J. R., Gerritz, S. W. & Alt, A., 2015, In : Journal of Medicinal Chemistry. 58, 10, p. 4220-4229 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Discovery of a novel class of negative allosteric modulator of the dopamine D2 receptor through fragmentation of a bitopic ligand

Mistry, S. N., Shonberg, J., Draper-Joyce, C. J., Klein Herenbrink, C., Michino, M., Shi, L., Christopoulos, A., Capuano, B., Scammells, P. J. & Lane, J. R. D., 2015, In : Journal of Medicinal Chemistry. 58, 17, p. 6819-6843 25 p.

Research output: Contribution to journalArticleResearchpeer-review

DNAM-1 expression marks an alternative program of NK cell maturation

Martinet, L., de Andrade, L. F., Guillerey, C., Lee, J. S., Liu, J., Souza-Fonseca-Guimaraes, F., Hutchinson, D. S., Kolesnik, T. B., Nicholson, S. E., Huntington, N. D. & Smyth, M. J., 2015, In : Cell Reports. 11, 1, p. 85 - 97 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Effect of a broad-specificity chemokine-binding protein on brain leukocyte infiltration and infarct development

Lee, S. S., Chu, H. X., Kim, H. A. H., Real, N. C., Sharif, S., Fleming, S. B., Mercer, A. A., Wise, L., Drummond, G. R. & Sobey, C. G., 2015, In : Stroke. 46, 2, p. 537 - 544 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Effect of a selective mas receptor agonist in cerebral ischemia in vitro and in vivo

Lee, S. S., Evans, M. A., Chu, H. X., Kim, H. H. A., Widdop, R. E., Drummond, G. R. & Sobey, C. G., 2015, In : PLoS ONE. 10, 11, 11 p., e0142087.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Electrophysiological, electroanatomical, and structural remodeling of the atria as consequences of sustained obesity

Mahajan, R., Lau, D. H., Brooks, A. G., Shipp, N. J., Manavis, J., Wood, J. P. M., Finnie, J. W., Samuel, C. S., Royce, S. G., Twomey, D. J., Thanigaimani, S., Kalman, J. M. & Sanders, P., 2015, In : Journal of the American College of Cardiology. 66, 1, p. 1 - 11 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Emerging roles of the {gamma}-secretase-notch axis in inflammation

Cheng, Y-L., Choi, Y., Sobey, C. G., Arumugam, T. V. & Jo, D-G., 2015, In : Pharmacology and Therapeutics. 147, p. 80 - 90 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Endogenous allosteric modulators of G protein-coupled receptors

Van Der Westhuizen, E. T., Valant, C., Sexton, P. & Christopoulos, A., 2015, In : Journal of Pharmacology and Experimental Therapeutics. 353, 2, p. 246 - 260 15 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Endosomal gene expression: a new indicator for prostate cancer patient prognosis?

Johnson, I. R. D., Parkinson-Lawrence, E. J., Keegan, H., Spillane, C. D., Barry-O'Crowley, J., Watson, W. R., Selemidis, S., Butler, L. M., O'Leary, J. J. & Brooks, D. A., 2015, In : Oncotarget. 6, 35, p. 37919 - 37929 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Eosinophilic esophagitis: A clinicopathological review

Philpott, H., Nandurkar, S., Thien, F., Gibson, P. R. & Royce, S. G., 2015, In : Pharmacology and Therapeutics. 146, p. 12 - 22 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Erratum: The pharmacokinetics and pharmacodynamics of severe aldicarb toxicity after overdose (Clinical Toxicology (2015) (1-3))

Michael, A. P., Mostafa, A., Cooper, J. M., Grice, J. E., Roberts, M. S. & Isbister, G. K., 9 Aug 2015, In : Clinical Toxicology. 53, 7, p. 788 1 p.

Research output: Contribution to journalComment / DebateOtherpeer-review

Evidence that Ly6C(hi) monocytes are protective in acute ischemic stroke by promoting M2 macrophage polarization

Chu, H. X., Broughton, B. R. S., Kim, H. H. A., Lee, S. S., Drummond, G. R. & Sobey, C. G., 2015, In : Stroke. 46, 7, p. 1929 - 1937 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Fatty acid-binding proteins 1 and 2 differentially modulate the activation of peroxisome proliferator-activated receptor alpha in a ligand-selective manner

Hughes, M. L. R., Liu, B., Halls, M. L., Wagstaff, K. M., Patil, R., Velkov, T., Jans, D. A., Bunnett, N. W., Scanlon, M. & Porter, C. J., 2015, In : Journal of Biological Chemistry. 290, 22, p. 13895 - 13906 12 p.

Research output: Contribution to journalArticleResearchpeer-review