Research Output

2016

Cerebral small vessel disease: Targeting oxidative stress as a novel therapeutic strategy?

De Silva, T. M. & Miller, A. A., 17 Mar 2016, In : Frontiers in Pharmacology. 7, 18 p., 61.

Research output: Contribution to journalReview ArticleOtherpeer-review

Open Access
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32 Citations (Scopus)

Changes in hypoxia-inducible factor-1 (HIF-1) and regulatory prolyl hydroxylase (PHD) enzymes following hypoxic-ischemic injury in the neonatal rat

Chu, H. X. & Jones, N. M., Mar 2016, In : Neurochemical Research. 41, 3, p. 515-522 8 p.

Research output: Contribution to journalArticleResearchpeer-review

7 Citations (Scopus)

Characteristics of renal sympathetic nerve single units in rabbits with angiotensin-induced hypertension

Burke, S. L., Lukoshkova, E. V. & Head, G. A., 1 Jan 2016, In : Experimental Physiology. 101, 1, p. 50-66 17 p.

Research output: Contribution to journalArticleResearchpeer-review

2 Citations (Scopus)
10 Citations (Scopus)

CIS is a potent checkpoint in NK cell-mediated tumor immunity

Delconte, R. B., Kolesnik, T. B., Dagley, L. F., Rautela, J., Shi, W., Putz, E. M., Stannard, K., Zhang, J. G., Teh, C. E-Y., Firth, M., Ushiki, T., Andoniou, C. E., Degli-Esposti, M. A., Sharp, P. P., Sanvitale, C. E., Infusini, G., Liau, N. P. D., Linossi, E. M., Burns, C. J., Carotta, S. & 12 others, Gray, D. H. D., Seillet, C., Hutchinson, D. S., Belz, G. T., Webb, A. I., Alexander, W. S., Li, S. S., Bullock, A. N., Babon, J. J., Smyth, M. J., Nicholson, S. E. & Huntington, N. D., 21 Jun 2016, In : Nature Immunology. 17, 7, p. 816-824 9 p.

Research output: Contribution to journalArticleResearchpeer-review

93 Citations (Scopus)

Clickable Photoaffinity Ligands for Metabotropic Glutamate Receptor 5 Based on Select Acetylenic Negative Allosteric Modulators

Gregory, K., Velagaleti, R., Thal, D. M., Brady, R. M., Christopoulos, A., Conn, P. J. & Lapinsky, D. J., 15 Jul 2016, In : ACS Chemical Biology. 11, 7, p. 1870-1879 10 p.

Research output: Contribution to journalArticleResearchpeer-review

15 Citations (Scopus)

Clinical and pharmacological investigation of Myotoxicity in Sri Lankan Russell’s Viper (Daboia russelii) envenoming

Silva, A., Johnston, C., Kuruppu, S., Kneisz, D., Maduwage, K., Kleifeld, O., Smith, A. I., Siribaddana, S., Buckley, N. A., Hodgson, W. C. & Isbister, G. K., 2 Dec 2016, In : PLoS Neglected Tropical Diseases. 10, 12, 18 p., 0005172.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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8 Citations (Scopus)

Combining an epithelial repair factor and anti-fibrotic with a corticosteroid offers optimal treatment for allergic airways disease

Patel, K. P., Giraud, A. S., Samuel, C. S. & Royce, S. G., 2016, In : British Journal of Pharmacology. 173, 12, p. 2016 - 2029 14 p.

Research output: Contribution to journalArticleResearchpeer-review

5 Citations (Scopus)

Comparison of sympathetic nerve activity normalization procedures in conscious rabbits

Burke, S. L., Lim, K., Moretti, J-L. & Head, G. A., 1 May 2016, In : American Journal of Physiology - Heart and Circulatory Physiology. 310, 9, p. H1222-H1232 11 p.

Research output: Contribution to journalArticleResearchpeer-review

5 Citations (Scopus)

Compound 21, a selective agonist of angiotensin AT2 receptors, prevents endothelial inflammation and leukocyte adhesion in vitro and in vivo

Sampson, A. K., Irvine, J. C., Shihata, W. A., Dragoljevic, D., Lumsden, N., Huet, O., Barnes, T., Unger, T., Steckelings, U. M., Jennings, G. L., Widdop, R. E. & Chin-Dusting, J. P. F., 1 Feb 2016, In : British Journal of Pharmacology. 173, 4, p. 729-740 12 p.

Research output: Contribution to journalArticleResearchpeer-review

30 Citations (Scopus)

Contribution of Orexin to the neurogenic hypertension in BPH/2J mice

Jackson, K. L., Dampney, B. W., Moretti, J-L., Stevenson, E. R., Davern, P. J., Carrive, P. & Head, G. A., May 2016, In : Journal of Hypertension. 67, 5, p. 959-969 11 p.

Research output: Contribution to journalArticleResearchpeer-review

19 Citations (Scopus)

CORRIGENDUM: N-terminal domain of Bothrops asper Myotoxin II Enhances the Activity of Endothelin Converting Enzyme-1 and Neprilysin

Smith, A. I., Rajapakse, N. W., Kleifeld, O., Lomonte, B., Sikanyika, N. L., Spicer, A. J., Hodgson, W. C., Conroy, P., Small, D. H., Kaye, D. M., Parkington, H. C., Whisstock, J. & Kuruppu, D. M. S., 2016, In : Scientific Reports. 6, Article # 24333, p. 1 - 1 1 p.

Research output: Contribution to journalArticleOther

Could burning fat start with a brite spark? Pharmacological and nutritional ways to promote thermogenesis

Merlin, J., Evans, B. A., Dehvari, N., Sato, M., Bengtsson, T. & Hutchinson, D. S., 2016, In : Molecular Nutrition and Food Research. 60, 1, p. 18-42 25 p.

Research output: Contribution to journalArticleResearchpeer-review

26 Citations (Scopus)

Cross-neutralisation of in vitro neurotoxicity of asian and Australian snake neurotoxins and venoms by different antivenoms

Silva, A., Hodgson, W. C. & Isbister, G. K., 1 Oct 2016, In : Toxins. 8, 10, 18 p., 302.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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12 Citations (Scopus)

Crystal structures of the M1 and M4 muscarinic acetylcholine receptors

Thal, D. M., Sun, B., Feng, D., Nawaratne, V., Leach, K., Felder, C. C., Bures, M. G., Evans, D. A., Weis, W. I., Bachhawat, P., Kobilka, T. S., Sexton, P. M., Kobilka, B. K. & Christopoulos, A., 17 Mar 2016, In : Nature. 531, 7594, p. 335-340 6 p.

Research output: Contribution to journalArticleResearchpeer-review

140 Citations (Scopus)

Decorated self-assembling β3-tripeptide foldamers form cell adhesive scaffolds

Luder, K., Kulkarni, K., Lee, H. W., Widdop, R. E., Del Borgo, M. P. & Aguilar, M-I., 29 Feb 2016, In : Chemical Communications. 52, 24, p. 4549-4552 4 p.

Research output: Contribution to journalArticleResearchpeer-review

15 Citations (Scopus)

Detection of snake venom in post-antivenom samples by dissociation treatment followed by Enzyme Immunoassay

Maduwage, K. P., O’Leary, M. A., Silva, A. & Isbister, G. K., 1 May 2016, In : Toxins. 8, 5, 9 p., 130.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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4 Citations (Scopus)

Distribution and trafficking of the μ-opioid receptor in enteric neurons of the guinea pig

Lay, J., Carbone, S. E., Dicello, J. J., Bunnett, N., Canals, M. & Poole, D. P., 1 Aug 2016, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 311, 2, p. G252-G266 15 p.

Research output: Contribution to journalArticleResearchpeer-review

12 Citations (Scopus)

Effect of Endothelin-1 on Baroreflexes and the Cardiovascular Action of Clonidine in Conscious Rabbits

Lim, K., van den Buuse, M. & Head, G. A., 28 Jul 2016, In : Frontiers in Physiology. 7, JUL, 9 p., 00321.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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2 Citations (Scopus)

Effects of animal venoms and toxins on hallmarks of cancer

Chaisakul, J., Hodgson, W. C., Kuruppu, S. & Prasongsook, N., 15 Jul 2016, In : Journal of Cancer. 7, 11, p. 1571-1578 8 p.

Research output: Contribution to journalReview ArticleOtherpeer-review

31 Citations (Scopus)

Efficacy of Indian polyvalent snake antivenoms against Sri Lankan snake venoms: lethality studies or clinically focussed in vitro studies

Maduwage, K., Silva, A., O'Leary, M. A., Hodgson, W. C. & Isbister, G. K., 27 May 2016, In : Scientific Reports. 6, 11 p., 26778.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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26 Citations (Scopus)

Efficacy of intravenous hydrocortisone administered 2–4 h prior to antivenom as prophylaxis against adverse drug reactions to snake antivenom in Sri Lanka: An open labelled randomized controlled trial

Kularatne, S. A. M., Weerakoon, K., Silva, A., Maduwage, K., Walathara, C., Rathnayake, I., Medagedara, S., Paranagama, R., Mendis, S. & Kumarasiri, P. V. R., 15 Sep 2016, In : Toxicon : official journal of the International Society on Toxinology. 120, p. 159-165 7 p.

Research output: Contribution to journalArticleResearchpeer-review

3 Citations (Scopus)

Engineering of a novel simplified human insulin-like peptide 5 agonist

Patil, N. A., Hughes, R. A., Rosengren, K. J., Kocan, M., Ang, S. Y., Tailhades, J., Separovic, F., Summers, R. J., Grosse, J., Wade, J., Bathgate, R. A. D. & Hossain, M. A., 10 Mar 2016, In : Journal of Medicinal Chemistry. 59, 5, p. 2118-2125 8 p.

Research output: Contribution to journalArticleResearchpeer-review

14 Citations (Scopus)

Enhanced serelaxin signalling in co-cultures of human primary endothelial and smooth muscle cells

Sarwar, M., Samuel, C. S., Bathgate, R., Stewart, D. R. & Summers, R. J., 2016, In : British Journal of Pharmacology. 173, 3, p. 484 - 496 13 p.

Research output: Contribution to journalArticleResearchpeer-review

17 Citations (Scopus)

Erratum: Multiphoton imaging reveals a new leukocyte recruitment paradigm in the glomerulus (Nature Medicine (2013) 19 (107-112))

Devi, S., Li, A., Westhorpe, C. L. V., Lo, C. Y., Abeynaike, L. D., Snelgrove, S. L., Hall, P., Ooi, J. D., Sobey, C. G., Kitching, A. R. & Hickey, M. J., 6 Apr 2016, In : Nature Medicine. 22, 4, p. 446 1 p.

Research output: Contribution to journalComment / DebateOtherpeer-review

1 Citation (Scopus)

Estrogens do not protect, but androgens exacerbate, collagen accumulation in the female mouse kidney after ureteric obstruction

Hewitson, T. D., Boon, W. C., Simpson, E. R., Smith, E. R. & Samuel, C. S., 1 Aug 2016, In : Life Sciences. 158, p. 130-136 7 p.

Research output: Contribution to journalArticleResearchpeer-review

11 Citations (Scopus)

Evidence of CCR2-independent transmigration of Ly6Chi monocytes into the brain after permanent cerebral ischemia in mice

Chu, H. X., Kim, H. A., Lee, S., Broughton, B. R. S., Drummond, G. R. & Sobey, C. G., 15 Apr 2016, In : Brain Research. 1637, p. 118-127 10 p.

Research output: Contribution to journalArticleResearchpeer-review

10 Citations (Scopus)

Extracellular loop 2 of the adenosine A1 receptor has a key role in orthosteric ligand affinity and agonist efficacy

Nguyen, A. T. N., Baltos, J-A., Thomas, T., Nguyen, T. D., Lopez Munoz, L., Gregory, K. J., White, P. J., Sexton, P. M., Christopoulos, A. & May, L. T., 1 Dec 2016, In : Molecular Pharmacology. 90, 6, p. 703-714 12 p.

Research output: Contribution to journalArticleResearchpeer-review

31 Citations (Scopus)

Ghrelin-related peptides do not modulate vasodilator nitric oxide production or superoxide levels in mouse systemic arteries

Ku, J. M., Sleeman, M. W., Sobey, C. G., Andrews, Z. B. & Miller, A. A., Apr 2016, In : Clinical and Experimental Pharmacology and Physiology. 43, 4, p. 468-475 8 p.

Research output: Contribution to journalArticleResearchpeer-review

2 Citations (Scopus)

Glucagon-like peptide-1 and its class B G protein-coupled receptors: a long march to therapeutic successes

de Graaf, C., Donnelly, D., Wootten, D., Lau, J., Sexton, P. M., Miller, L. J., Ahn, J-M., Liao, J., Fletcher, M. M., Yang, D., Brown, A. J. H., Zhou, C., Deng, J. & Wang, M-W., 1 Oct 2016, In : Pharmacological Reviews. 68, 4, p. 954-1013 60 p.

Research output: Contribution to journalArticleResearchpeer-review

79 Citations (Scopus)

Glucose-6-phosphate dehydrogenase contributes to the regulation of glucose uptake in skeletal muscle

Lee-Young, R. S., Hoffman, N. J., Murphy, K. T., Henstridge, D. C., Samocha-Bonet, D., Siebel, A. L., Iliades, P., Zivanovic, B., Hong, Y. H., Colgan, T. D., Kraakman, M. J., Bruce, C. R., Gregorevic, P., McConell, G. K., Lynch, G. S., Drummond, G. R., Kingwell, B. A., Greenfield, J. R. & Febbraio, M. A., 1 Nov 2016, In : Molecular Metabolism. 5, 11, p. 1083-1091 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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8 Citations (Scopus)

G protein coupled receptor 18: a potential role for endocannabinoid signaling in metabolic dysfunction

Rajaraman, G., Simcocks, A., Hryciw, D. H., Hutchinson, D. S. & McAinch, A. J., 1 Jan 2016, In : Molecular Nutrition and Food Research. 60, 1, p. 92-102 11 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

12 Citations (Scopus)

G protein-coupled receptor trafficking and signalling in the enteric nervous system: the past, present and future

Poole, D. P. & Bunnett, N. W., 2016, The Enteric Nervous System: 30 Years Later. Brierley, S. & Costa, M. (eds.). Springer, p. 145-152 8 p. (Advances in Experimental Medicine and Biology; vol. 891).

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Otherpeer-review

7 Citations (Scopus)

Inflammasome activity is essential for one kidney/deoxycorticosterone acetate/salt-induced hypertension in mice

Krishnan, S. M., Dowling, J. K., Ling, Y. H., Diep, H., Chan, C. T., Ferens, D., Kett, M. M., Pinar, A., Samuel, C. S., Vinh, A., Arumugam, T. V., Hewitson, T. D., Kemp-Harper, B. K., Robertson, A. A. B., Cooper, M. A., Latz, E., Mansell, A., Sobey, C. G. & Drummond, G. R., 1 Feb 2016, In : British Journal of Pharmacology. 173, 4, p. 752-765 14 p.

Research output: Contribution to journalArticleResearchpeer-review

66 Citations (Scopus)

Influenza A virus infection and cigarette smoke impair bronchodilator responsiveness to β-adrenoceptor agonists in mouse lung

Donovan, C., Seow, H. J., Bourke, J. E. & Vlahos, R., May 2016, In : Clinical Science. 130, 10, p. 829-837 9 p.

Research output: Contribution to journalArticleResearchpeer-review

8 Citations (Scopus)

Isolation and Pharmacological Characterization of α-Elapitoxin-Ot1a, a Short-Chain Postsynaptic neurotoxin from the Venom of the Western Desert Taipan, Oxyuranus temporalis

Barber, C. M., Rusmili, M. R. A. & Hodgson, W. C., 29 Feb 2016, In : Toxins. 8, 3, 12 p., 58.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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2 Citations (Scopus)
21 Citations (Scopus)

Legumain is activated in macrophages during pancreatitis

Edgington-Mitchell, L. E., Wartmann, T., Fleming, A. K., Gocheva, V., van der Linden, W. A., Withana, N. P., Verdoes, M., Aurelio, L., Edgington-Mitchell, D., Lieu, T., Parker, B. S., Graham, B., Reinheckel, T., Furness, J. B., Joyce, J. A., Storz, P., Halangk, W., Bogyo, M. & Bunnett, N. W., Sep 2016, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 311, 3, p. G548-G560 13 p.

Research output: Contribution to journalArticleResearchpeer-review

12 Citations (Scopus)

Ligand-dependent modulation of G protein conformation alters drug efficacy

Furness, S. G. B., Liang, Y-L., Nowell, C. J., Halls, M. L., Wookey, P. J., Dal Maso, E., Inoue, A., Christopoulos, A., Wootten, D. & Sexton, P. M., 20 Oct 2016, In : Cell. 167, 3, p. 739-749 11 p.

Research output: Contribution to journalArticleResearchpeer-review

53 Citations (Scopus)

Ligand-independent adenosine A2B receptor constitutive activity as a promoter of prostate cancer cell proliferation

Vecchio, E. A., Tan, C. Y. R., Gregory, K., Christopoulos, A., White, P. J. & May, L. T., 1 Apr 2016, In : Journal of Pharmacology and Experimental Therapeutics. 357, 1, p. 36-44 9 p.

Research output: Contribution to journalArticleResearchpeer-review

33 Citations (Scopus)

Low dose dietary nitrate improves endothelial dysfunction and plaque stability in the ApoE−/− mouse fed a high fat diet

Bakker, J. R., Bondonno, N. P., Gaspari, T. A., Kemp-Harper, B. K., McCashney, A. J., Hodgson, J. M., Croft, K. D. & Ward, N. C., 1 Oct 2016, In : Free Radical Biology and Medicine. 99, p. 189-198 10 p.

Research output: Contribution to journalArticleResearchpeer-review

6 Citations (Scopus)

Macromolecular hydrogen sulfide donors trigger spatiotemporally confined changes in cell signaling

Ercole, F., Mansfeld, F. M., Kavallaris, M., Whittaker, M. R., Quinn, J. F., Halls, M. L. & Davis, T. P., 11 Jan 2016, In : Biomacromolecules. 17, 1, p. 371-383 13 p.

Research output: Contribution to journalArticleResearchpeer-review

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21 Citations (Scopus)

Metabotropic glutamate receptor subtype 5: molecular pharmacology, allosteric modulation and stimulus bias

Sengmany, K. & Gregory, K. J., 1 Oct 2016, In : British Journal of Pharmacology. 173, 20, p. 3001-3017 17 p.

Research output: Contribution to journalArticleResearchpeer-review

23 Citations (Scopus)

Microglial activation and progressive brain changes in schizophrenia

Laskaris, L., Di Biase, M. A., Everall, I. P., Chana, G., Christopoulos, A., Skafidas, E. S., Cropley, V. L. & Pantelis, C., 2016, In : British Journal of Pharmacology. 173, 4, p. 666-680 15 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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77 Citations (Scopus)

Microvascular dysfunction and cognitive impairment

De Silva, T. M. & Faraci, F. M., 17 Mar 2016, In : Cellular and Molecular Neurobiology. 36, 2, p. 241-258 18 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

59 Citations (Scopus)

Molecular and cellular mechanisms of glucagon-like peptide-1 receptor agonist-mediated attenuation of cardiac fibrosis

Gaspari, T., Brdar, M., Lee, H. W., Spizzo, I., Hu, Y., Widdop, R. E., Simpson, R. W. & Dear, A. E., 2016, In : Diabetes and Vascular Disease Research. 13, 1, p. 56-68 13 p.

Research output: Contribution to journalArticleResearchpeer-review

15 Citations (Scopus)

Molecular mechanisms of action of M5 muscarinic acetylcholine receptor allosteric modulators

Berizzi, A. E., Gentry, P. R., Rueda, P., Hoedt, S. D., Sexton, P. M., Langmead, C. J. & Christopoulos, A., 1 Oct 2016, In : Molecular Pharmacology. 90, 4, p. 427-436 10 p.

Research output: Contribution to journalArticleResearchpeer-review

11 Citations (Scopus)

Monotreme glucagon-like peptide-1 in venom and gut: one gene - two very different functions

Tsend-Ayush, E., He, C., Myers, M. A., Andrikopoulos, S., Wong, N., Sexton, P. M., Wootten, D., Forbes, B. E. & Grutzner, F., 29 Nov 2016, In : Scientific Reports. 6, 12 p., 37744.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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5 Citations (Scopus)

Multivalent approaches and beyond: novel tools for the investigation of dopamine D2 receptor pharmacology

Kopinathan, A., Scammells, P. J., Lane, J. R. & Capuano, B., 1 Jul 2016, In : Future Medicinal Chemistry. 8, 11, p. 1349-1372 24 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

3 Citations (Scopus)

Murine GPRC6A mediates cellular responses to L-amino acids, but not osteocalcin variants

Rueda, P., Harley, E., Lu, Y., Stewart, G. D., Fabb, S., Diepenhorst, N., Cremers, B., Rouillon, M-H., Wehrle, I., Geant, A., Lamarche, G., Leach, K., Charman, W. N., Christopoulos, A., Summers, R. J., Sexton, P. M. & Langmead, C. J., 1 Jan 2016, In : PLoS ONE. 11, 1, p. 1-19 19 p., e0146846.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
27 Citations (Scopus)