Research Output 1986 2019

2016

Decorated self-assembling β3-tripeptide foldamers form cell adhesive scaffolds

Luder, K., Kulkarni, K., Lee, H. W., Widdop, R. E., Del Borgo, M. P. & Aguilar, M-I., 29 Feb 2016, In : Chemical Communications. 52, 24, p. 4549-4552 4 p.

Research output: Contribution to journalArticleResearchpeer-review

Detection of snake venom in post-antivenom samples by dissociation treatment followed by Enzyme Immunoassay

Maduwage, K. P., O’Leary, M. A., Silva, A. & Isbister, G. K., 1 May 2016, In : Toxins. 8, 5, 9 p., 130.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Distribution and trafficking of the μ-opioid receptor in enteric neurons of the guinea pig

Lay, J., Carbone, S. E., Dicello, J. J., Bunnett, N., Canals, M. & Poole, D. P., 1 Aug 2016, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 311, 2, p. G252-G266 15 p.

Research output: Contribution to journalArticleResearchpeer-review

Effect of Endothelin-1 on Baroreflexes and the Cardiovascular Action of Clonidine in Conscious Rabbits

Lim, K., van den Buuse, M. & Head, G. A., 28 Jul 2016, In : Frontiers in Physiology. 7, JUL, 9 p., 00321.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Effects of animal venoms and toxins on hallmarks of cancer

Chaisakul, J., Hodgson, W. C., Kuruppu, S. & Prasongsook, N., 15 Jul 2016, In : Journal of Cancer. 7, 11, p. 1571-1578 8 p.

Research output: Contribution to journalReview ArticleOtherpeer-review

Efficacy of Indian polyvalent snake antivenoms against Sri Lankan snake venoms: lethality studies or clinically focussed in vitro studies

Maduwage, K., Silva, A., O'Leary, M. A., Hodgson, W. C. & Isbister, G. K., 27 May 2016, In : Scientific Reports. 6, 11 p., 26778.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Efficacy of intravenous hydrocortisone administered 2–4 h prior to antivenom as prophylaxis against adverse drug reactions to snake antivenom in Sri Lanka: An open labelled randomized controlled trial

Kularatne, S. A. M., Weerakoon, K., Silva, A., Maduwage, K., Walathara, C., Rathnayake, I., Medagedara, S., Paranagama, R., Mendis, S. & Kumarasiri, P. V. R., 15 Sep 2016, In : Toxicon : official journal of the International Society on Toxinology. 120, p. 159-165 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Engineering of a novel simplified human insulin-like peptide 5 agonist

Patil, N. A., Hughes, R. A., Rosengren, K. J., Kocan, M., Ang, S. Y., Tailhades, J., Separovic, F., Summers, R. J., Grosse, J., Wade, J., Bathgate, R. A. D. & Hossain, M. A., 10 Mar 2016, In : Journal of Medicinal Chemistry. 59, 5, p. 2118-2125 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Enhanced serelaxin signalling in co-cultures of human primary endothelial and smooth muscle cells

Sarwar, M., Samuel, C. S., Bathgate, R., Stewart, D. R. & Summers, R. J., 2016, In : British Journal of Pharmacology. 173, 3, p. 484 - 496 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Erratum: Multiphoton imaging reveals a new leukocyte recruitment paradigm in the glomerulus (Nature Medicine (2013) 19 (107-112))

Devi, S., Li, A., Westhorpe, C. L. V., Lo, C. Y., Abeynaike, L. D., Snelgrove, S. L., Hall, P., Ooi, J. D., Sobey, C. G., Kitching, A. R. & Hickey, M. J., 6 Apr 2016, In : Nature Medicine. 22, 4, p. 446 1 p.

Research output: Contribution to journalComment / DebateOtherpeer-review

Estrogens do not protect, but androgens exacerbate, collagen accumulation in the female mouse kidney after ureteric obstruction

Hewitson, T. D., Boon, W. C., Simpson, E. R., Smith, E. R. & Samuel, C. S., 1 Aug 2016, In : Life Sciences. 158, p. 130-136 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Evidence of CCR2-independent transmigration of Ly6Chi monocytes into the brain after permanent cerebral ischemia in mice

Chu, H. X., Kim, H. A., Lee, S., Broughton, B. R. S., Drummond, G. R. & Sobey, C. G., 15 Apr 2016, In : Brain Research. 1637, p. 118-127 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Extracellular loop 2 of the adenosine A1 receptor has a key role in orthosteric ligand affinity and agonist efficacy

Nguyen, A. T. N., Baltos, J-A., Thomas, T., Nguyen, T. D., Lopez Munoz, L., Gregory, K. J., White, P. J., Sexton, P. M., Christopoulos, A. & May, L. T., 1 Dec 2016, In : Molecular Pharmacology. 90, 6, p. 703-714 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Ghrelin-related peptides do not modulate vasodilator nitric oxide production or superoxide levels in mouse systemic arteries

Ku, J. M., Sleeman, M. W., Sobey, C. G., Andrews, Z. B. & Miller, A. A., Apr 2016, In : Clinical and Experimental Pharmacology and Physiology. 43, 4, p. 468-475 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Glucagon-like peptide-1 and its class B G protein-coupled receptors: a long march to therapeutic successes

de Graaf, C., Donnelly, D., Wootten, D., Lau, J., Sexton, P. M., Miller, L. J., Ahn, J-M., Liao, J., Fletcher, M. M., Yang, D., Brown, A. J. H., Zhou, C., Deng, J. & Wang, M-W., 1 Oct 2016, In : Pharmacological Reviews. 68, 4, p. 954-1013 60 p.

Research output: Contribution to journalArticleResearchpeer-review

Glucose-6-phosphate dehydrogenase contributes to the regulation of glucose uptake in skeletal muscle

Lee-Young, R. S., Hoffman, N. J., Murphy, K. T., Henstridge, D. C., Samocha-Bonet, D., Siebel, A. L., Iliades, P., Zivanovic, B., Hong, Y. H., Colgan, T. D., Kraakman, M. J., Bruce, C. R., Gregorevic, P., McConell, G. K., Lynch, G. S., Drummond, G. R., Kingwell, B. A., Greenfield, J. R. & Febbraio, M. A., 1 Nov 2016, In : Molecular Metabolism. 5, 11, p. 1083-1091 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

G protein coupled receptor 18: a potential role for endocannabinoid signaling in metabolic dysfunction

Rajaraman, G., Simcocks, A., Hryciw, D. H., Hutchinson, D. S. & McAinch, A. J., 1 Jan 2016, In : Molecular Nutrition and Food Research. 60, 1, p. 92-102 11 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

G protein-coupled receptor trafficking and signalling in the enteric nervous system: the past, present and future

Poole, D. P. & Bunnett, N. W., 2016, The Enteric Nervous System: 30 Years Later. Brierley, S. & Costa, M. (eds.). Springer, p. 145-152 8 p. (Advances in Experimental Medicine and Biology; vol. 891).

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Otherpeer-review

Inflammasome activity is essential for one kidney/deoxycorticosterone acetate/salt-induced hypertension in mice

Krishnan, S. M., Dowling, J. K., Ling, Y. H., Diep, H., Chan, C. T., Ferens, D., Kett, M. M., Pinar, A., Samuel, C. S., Vinh, A., Arumugam, T. V., Hewitson, T. D., Kemp-Harper, B. K., Robertson, A. A. B., Cooper, M. A., Latz, E., Mansell, A., Sobey, C. G. & Drummond, G. R., 1 Feb 2016, In : British Journal of Pharmacology. 173, 4, p. 752-765 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Influenza A virus infection and cigarette smoke impair bronchodilator responsiveness to β-adrenoceptor agonists in mouse lung

Donovan, C., Seow, H. J., Bourke, J. E. & Vlahos, R., May 2016, In : Clinical Science. 130, 10, p. 829-837 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Isolation and Pharmacological Characterization of α-Elapitoxin-Ot1a, a Short-Chain Postsynaptic neurotoxin from the Venom of the Western Desert Taipan, Oxyuranus temporalis

Barber, C. M., Rusmili, M. R. A. & Hodgson, W. C., 29 Feb 2016, In : Toxins. 8, 3, 12 p., 58.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Legumain is activated in macrophages during pancreatitis

Edgington-Mitchell, L. E., Wartmann, T., Fleming, A. K., Gocheva, V., van der Linden, W. A., Withana, N. P., Verdoes, M., Aurelio, L., Edgington-Mitchell, D., Lieu, T., Parker, B. S., Graham, B., Reinheckel, T., Furness, J. B., Joyce, J. A., Storz, P., Halangk, W., Bogyo, M. & Bunnett, N. W., Sep 2016, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 311, 3, p. G548-G560 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Ligand-dependent modulation of G protein conformation alters drug efficacy

Furness, S. G. B., Liang, Y-L., Nowell, C. J., Halls, M. L., Wookey, P. J., Dal Maso, E., Inoue, A., Christopoulos, A., Wootten, D. & Sexton, P. M., 20 Oct 2016, In : Cell. 167, 3, p. 739-749 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Ligand-independent adenosine A2B receptor constitutive activity as a promoter of prostate cancer cell proliferation

Vecchio, E. A., Tan, C. Y. R., Gregory, K., Christopoulos, A., White, P. J. & May, L. T., 1 Apr 2016, In : Journal of Pharmacology and Experimental Therapeutics. 357, 1, p. 36-44 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Low dose dietary nitrate improves endothelial dysfunction and plaque stability in the ApoE−/− mouse fed a high fat diet

Bakker, J. R., Bondonno, N. P., Gaspari, T. A., Kemp-Harper, B. K., McCashney, A. J., Hodgson, J. M., Croft, K. D. & Ward, N. C., 1 Oct 2016, In : Free Radical Biology and Medicine. 99, p. 189-198 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Macromolecular hydrogen sulfide donors trigger spatiotemporally confined changes in cell signaling

Ercole, F., Mansfeld, F. M., Kavallaris, M., Whittaker, M. R., Quinn, J. F., Halls, M. L. & Davis, T. P., 11 Jan 2016, In : Biomacromolecules. 17, 1, p. 371-383 13 p.

Research output: Contribution to journalArticleResearchpeer-review

File

Metabotropic glutamate receptor subtype 5: molecular pharmacology, allosteric modulation and stimulus bias

Sengmany, K. & Gregory, K. J., 1 Oct 2016, In : British Journal of Pharmacology. 173, 20, p. 3001-3017 17 p.

Research output: Contribution to journalArticleResearchpeer-review

Microglial activation and progressive brain changes in schizophrenia

Laskaris, L., Di Biase, M. A., Everall, I. P., Chana, G., Christopoulos, A., Skafidas, E. S., Cropley, V. L. & Pantelis, C., 2016, In : British Journal of Pharmacology. 173, 4, p. 666-680 15 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Microvascular dysfunction and cognitive impairment

De Silva, T. M. & Faraci, F. M., 17 Mar 2016, In : Cellular and Molecular Neurobiology. 36, 2, p. 241-258 18 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

Molecular and cellular mechanisms of glucagon-like peptide-1 receptor agonist-mediated attenuation of cardiac fibrosis

Gaspari, T., Brdar, M., Lee, H. W., Spizzo, I., Hu, Y., Widdop, R. E., Simpson, R. W. & Dear, A. E., 2016, In : Diabetes and Vascular Disease Research. 13, 1, p. 56-68 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Molecular mechanisms of action of M5 muscarinic acetylcholine receptor allosteric modulators

Berizzi, A. E., Gentry, P. R., Rueda, P., Hoedt, S. D., Sexton, P. M., Langmead, C. J. & Christopoulos, A., 1 Oct 2016, In : Molecular Pharmacology. 90, 4, p. 427-436 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Monotreme glucagon-like peptide-1 in venom and gut: one gene - two very different functions

Tsend-Ayush, E., He, C., Myers, M. A., Andrikopoulos, S., Wong, N., Sexton, P. M., Wootten, D., Forbes, B. E. & Grutzner, F., 29 Nov 2016, In : Scientific Reports. 6, 12 p., 37744.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Multivalent approaches and beyond: novel tools for the investigation of dopamine D2 receptor pharmacology

Kopinathan, A., Scammells, P. J., Lane, J. R. & Capuano, B., 1 Jul 2016, In : Future Medicinal Chemistry. 8, 11, p. 1349-1372 24 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

Murine GPRC6A mediates cellular responses to L-amino acids, but not osteocalcin variants

Rueda, P., Harley, E., Lu, Y., Stewart, G. D., Fabb, S., Diepenhorst, N., Cremers, B., Rouillon, M-H., Wehrle, I., Geant, A., Lamarche, G., Leach, K., Charman, W. N., Christopoulos, A., Summers, R. J., Sexton, P. M. & Langmead, C. J., 1 Jan 2016, In : PLoS ONE. 11, 1, p. 1-19 19 p., e0146846.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Neonatal pneumococcal colonisation caused by Influenza A infection alters lung function in adult mice

FitzPatrick, M., Royce, S. G., Langenbach, S., McQualter, J., Reading, P. C., Wijburg, O., Anderson, G. P., Stewart, A., Bourke, J. & Bozinovski, S., 2016, In : Scientific Reports. 6, p. 1 - 12 12 p., 22751.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Neuromuscular Effects of Common Krait (Bungarus caeruleus) Envenoming in Sri Lanka

Silva, A., Maduwage, K., Sedgwick, M., Pilapitiya, S., Weerawansa, P., Dahanayaka, N. J., Buckley, N. A., Johnston, C., Siribaddana, S. & Isbister, G. K., 1 Feb 2016, In : PLoS Neglected Tropical Diseases. 10, 2, 18 p., e0004368.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Neurotensin-induced miR-133α expression regulates neurotensin receptor 1 recycling through its downstream target aftiphilin

Law, I. K. M., Jensen, D., Bunnett, N. W. & Pothoulakis, C., 23 Feb 2016, In : Scientific Reports. 6, 14 p., 22195.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Neurotoxicity in Russells viper (Daboia russelii) envenoming in Sri Lanka: A clinical and neurophysiological study

Silva, A., Maduwage, K., Sedgwick, M., Pilapitiya, S., Weerawansa, P., Dahanayaka, N. J., Buckley, N. A., Siribaddana, S. & Isbister, G. K., 27 May 2016, In : Clinical Toxicology. 54, 5, p. 411-419 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Nitroxyl (HNO) reduces endothelial and monocyte activation and promotes M2 macrophage polarization

Andrews, K. L., Sampson, A. K., Irvine, J. C., Shihata, W. A., Michell, D. L., Lumsden, N. G., Lim, C., Huet, O., Drummond, G. R., Kemp-Harper, B. K. & Chin-Dusting, J. P. F., 2016, In : Clinical Science. 130, 18, p. 1629-1640 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Novel fused arylpyrimidinone based allosteric modulators of the M1 muscarinic acetylcholine receptor

Mistry, S. N., Lim, H., Jorg, M., Capuano, B., Christopoulos, A., Lane, J. R. & Scammells, P. J., 18 May 2016, In : ACS Chemical Neuroscience. 7, 5, p. 647-661 15 p.

Research output: Contribution to journalArticleResearchpeer-review

Novel irreversible agonists acting at the A1 adenosine receptor

Jorg, M., Glukhova, A., Abdul Ridha, A., Vecchio, E. A., Nguyen, A., Sexton, P., White, P., May, L., Christopoulos, A. & Scammells, P., 22 Dec 2016, In : Journal of Medicinal Chemistry. 59, 24, p. 11182-11194 13 p.

Research output: Contribution to journalArticleResearchpeer-review

N-terminal domain of Bothrops asper Myotoxin II Enhances the Activity of Endothelin Converting Enzyme-1 and Neprilysin

Smith, A. I., Rajapakse, N. W., Kleifeld, O., Lomonte, B., Sikanyika, N. L., Spicer, A. J., Hodgson, W. C., Conroy, P. J., Small, D. H., Kaye, D. M., Parkington, H. C., Whisstock, J. C. & Kuruppu, S. M. S., 2 Mar 2016, In : Scientific Reports. 6, 10 p., 22413.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Origin of Aberrant Blood Pressure and Sympathetic Regulation in Diet-Induced Obesity

Lim, K., Barzel, B., Burke, S. L., Armitage, J. A. & Head, G. A., 1 Aug 2016, In : Hypertension. 68, 2, p. 491-500 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Orthosteric, allosteric and biased signalling at the relaxin-3 receptor RXFP3

Kocan, M., Ang, S. Y. & Summers, R. J., 2016, In : Neurochemical Research. 41, 3, p. 610-619 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Plasma membrane localization of the μ-opioid receptor controls spatiotemporal signaling

Halls, M., Yeatman, H. R., Nowell, C. J., Thompson, G. L., Gondin, A. B., Civciristov, S., Bunnett, N. W., Lambert, N. A., Poole, D. P. & Canals, M., 9 Feb 2016, In : Science Signaling. 9, 414, p. 1-13 13 p., ra16.

Research output: Contribution to journalArticleResearchpeer-review

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Prediction of loops in G protein-coupled receptor homology models: effect of imprecise surroundings and constraints

Arora, B., Coudrat, T., Wootten, D., Christopoulos, A., Noronha, S. B. & Sexton, P. M., 25 Apr 2016, In : Journal of Chemical Information and Modeling. 56, 4, p. 671-686 16 p.

Research output: Contribution to journalArticleResearchpeer-review

Prognostic and mechanistic potential of progesterone sulfates in intrahepatic cholestasis of pregnancy and pruritus gravidarum

Abu-Hayyeh, S., Ovadia, C., Lieu, T., Jensen, D. D., Chambers, J., Dixon, P. H., Lovgren-Sandblom, A., Bolier, R., Tolenaars, D., Kremer, A. E., Syngelaki, A., Noori, M., Williams, D., Marin, J. J. G., Monte, M. J., Nicolaides, K. H., Beuers, U. H. W., Oude-Elferink, R., Seed, P. T., Chappell, L. & 3 othersMarschall, H-U., Bunnett, N. W. & Williamson, C., 2016, In : Hepatology. 63, 4, p. 1287-1298 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Promise and limitations of relaxin-based therapies in chronic fibrotic lung diseases

Royce, S. G., Bathgate, R. A. D. & Samuel, C. S., 1 Dec 2016, In : American Journal of Respiratory and Critical Care Medicine. 194, 11, p. 1434-1435 2 p.

Research output: Contribution to journalLetterOtherpeer-review