Research Output 1986 2019

2016

Accelerated structure-based design of chemically diverse allosteric modulators of a muscarinic G protein-coupled receptor

Miao, Y., Goldfeld, D. A., Moo, E. V., Sexton, P. M., Christopoulos, A., McCammon, J. A. & Valant, C., 20 Sep 2016, In : Proceedings of the National Academy of Sciences. 113, 38, p. E5675-E5684 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Adverse vascular remodelling is more sensitive than endothelial dysfunction to hyperglycaemia in diabetic rat mesenteric arteries

Kahlberg, N., Qin, C. X., Anthonisz, J., Jap, E., Ng, H. H., Jelinic, M., Parry, L. J., Kemp-Harper, B. K., Ritchie, R. H. & Leo, C. H., 1 Sep 2016, In : Pharmacological Research. 111, p. 325-335 11 p.

Research output: Contribution to journalArticleResearchpeer-review

A hydrogen-bonded polar network in the core of the glucagon-like peptide-1 receptor is a fulcrum for biased agonism: lessons from class B crystal structuress

Wootten, D., Reynolds, C. A., Koole, C., Smith, K. J., Mobarec, J. C., Simms, J., Quon, T., Coudrat, T., Furness, S. G. B., Miller, L. J., Christopoulos, A. & Sexton, P. M., 1 Mar 2016, In : Molecular Pharmacology. 89, 3, p. 335-347 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Airway remodeling and hyperreactivity in a model of bronchopulmonary dysplasia and their modulation by IL-1Ra

Royce, S. G., Nold, M. F., Bui, C. B-Q., Donovan, C., Lam, M., Lamanna, E., Rudloff, I., Bourke, J. E. & Nold-Petry, C. A., 1 Dec 2016, In : American Journal of Respiratory Cell and Molecular Biology. 55, 6, p. 858-868 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Aldosterone-induced oxidative stress and inflammation in the brain are mediated by the endothelial cell mineralocorticoid receptor

Dinh, Q. N., Young, M. J., Evans, M. A., Drummond, G. R., Sobey, C. G. & Chrissobolis, S., 2016, In : Brain Research. 1637, p. 146 - 153 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Allosteric Modulation as a Unifying Mechanism for Receptor Function and Regulation

Changeux, J. P. & Christopoulos, A., 25 Aug 2016, In : Cell. 166, 5, p. 1084-1102 19 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

An allosteric role for receptor activity-modifying proteins in defining GPCR pharmacology

Gingell, J. J., Simms, J., Barwell, J., Poyner, D., Watkins, H. A., Pioszak, A. A., Sexton, P. M. & Hay, D., 17 May 2016, In : Cell Discovery. 2, 14 p., 16012.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Angiotensin AT2-receptor stimulation improves survival and neurological outcome after experimental stroke in mice

Schwengel, K., Namsolleck, P., Lucht, K., Clausen, B. H., Lambertsen, K. L., Valero-Esquitino, V., Thone-Reineke, C., Müller, S., Widdop, R. E., Denton, K. M., Horiuchi, M., Iwai, M., Boato, F., Dahlof, B., Hallberg, A., Unger, T. & Steckelings, U. M., Aug 2016, In : Journal of Molecular Medicine. 94, 8, p. 957-966 10 p.

Research output: Contribution to journalArticleResearchpeer-review

A novel ligand of calcitonin receptor reveals a potential new sensor that modulates programmed cell death

Furness, S. G. B., Hare, D. L., Kourakis, A., Turnley, A. M. & Wookey, P. J., 2016, In : Cell Death Discovery. 2, 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Antagonism of the proinflammatory and pronociceptive actions of canonical and biased agonists of protease-activated receptor-2

Lieu, T., Savage, E., Zhao, P., Edgington-Mitchell, L., Barlow, N., Bron, R., Poole, D. P., McLean, P., Lohman, R. J., Fairlie, D. P. & Bunnett, N. W., 1 Sep 2016, In : British Journal of Pharmacology. 173, 18, p. 2752-2765 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Antifibrotic actions of Serelaxin: New roles for an old player

Samuel, C. S., Summers, R. J. & Hewitson, T. D., Jun 2016, In : Trends in Pharmacological Sciences. 37, 6, p. 485-497 13 p.

Research output: Contribution to journalReview ArticleOtherpeer-review

Apocynin and ebselen reduce influenza A virus-induced lung inflammation in cigarette smoke-exposed mice

Oostwoud, L. C., Gunasinghe, P., Seow, H. J., Ye, J. M., Selemidis, S., Bozinovski, S. & Vlahos, R., 15 Feb 2016, In : Scientific Reports. 6, 16 p., 20983.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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A single-chain derivative of the relaxin hormone is a functionally selective agonist of the G protein-coupled receptor, RXFP1

Hossain, M. A., Kocan, M., Yao, S. T., Royce, S. G., Nair, V. B., Siwek, C., Patil, N. A., Harrison, I. P., Rosengren, K. J., Selemidis, S., Summers, R. J., Wade, J. D., Bathgate, R. A. D. & Samuel, C. S., 2016, In : Chemical Science. 7, 6, p. 3805-3819 15 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Cardiac tissue injury and remodeling is dependent upon mr regulation of activation pathways in cardiac tissue macrophages

Shen, J. Z. L., Morgan, J., Tesch, G. H., Rickard, A., Chrissobolis, S., Drummond, G. R., Fuller, P. J. & Young, M., 1 Aug 2016, In : Endocrinology. 157, 8, p. 3213-3223 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Caveolae: A role in endothelial inflammation and mechanotransduction?

Shihata, W. A., Michell, D. L., Andrews, K. L. & Chin-Dusting, J. P. F., 20 Dec 2016, In : Frontiers in Physiology. 7, 9 p., 628.

Research output: Contribution to journalReview ArticleResearchpeer-review

Open Access
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Cell-specific mineralocorticoid receptors: Future therapeutic targets for stroke?

Dinh, Q. N., Drummond, G. R., Sobey, C. G. & Chrissobolis, S., 1 Aug 2016, In : Neural Regeneration Research. 11, 8, p. 1230-1231 2 p.

Research output: Contribution to journalComment / DebateOtherpeer-review

Central proopiomelanocortin but not neuropeptide Y mediates sympathoexcitation and hypertension in fat fed conscious rabbits

Barzel, B., Lim, K., Davern, P. J., Burke, S. L., Armitage, J. A. & Head, G. A., Mar 2016, In : Journal of Hypertension. 34, 3, p. 464-473 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Cerebral small vessel disease: Targeting oxidative stress as a novel therapeutic strategy?

De Silva, T. M. & Miller, A. A., 17 Mar 2016, In : Frontiers in Pharmacology. 7, 18 p., 61.

Research output: Contribution to journalReview ArticleOtherpeer-review

Open Access
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Changes in hypoxia-inducible factor-1 (HIF-1) and regulatory prolyl hydroxylase (PHD) enzymes following hypoxic-ischemic injury in the neonatal rat

Chu, H. X. & Jones, N. M., Mar 2016, In : Neurochemical Research. 41, 3, p. 515-522 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Characteristics of renal sympathetic nerve single units in rabbits with angiotensin-induced hypertension

Burke, S. L., Lukoshkova, E. V. & Head, G. A., 1 Jan 2016, In : Experimental Physiology. 101, 1, p. 50-66 17 p.

Research output: Contribution to journalArticleResearchpeer-review

CIS is a potent checkpoint in NK cell-mediated tumor immunity

Delconte, R. B., Kolesnik, T. B., Dagley, L. F., Rautela, J., Shi, W., Putz, E. M., Stannard, K., Zhang, J. G., Teh, C. E-Y., Firth, M., Ushiki, T., Andoniou, C. E., Degli-Esposti, M. A., Sharp, P. P., Sanvitale, C. E., Infusini, G., Liau, N. P. D., Linossi, E. M., Burns, C. J., Carotta, S. & 12 others, Gray, D. H. D., Seillet, C., Hutchinson, D. S., Belz, G. T., Webb, A. I., Alexander, W. S., Li, S. S., Bullock, A. N., Babon, J. J., Smyth, M. J., Nicholson, S. E. & Huntington, N. D., 21 Jun 2016, In : Nature Immunology. 17, 7, p. 816-824 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Clickable Photoaffinity Ligands for Metabotropic Glutamate Receptor 5 Based on Select Acetylenic Negative Allosteric Modulators

Gregory, K., Velagaleti, R., Thal, D. M., Brady, R. M., Christopoulos, A., Conn, P. J. & Lapinsky, D. J., 15 Jul 2016, In : ACS Chemical Biology. 11, 7, p. 1870-1879 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Clinical and pharmacological investigation of Myotoxicity in Sri Lankan Russell’s Viper (Daboia russelii) envenoming

Silva, A., Johnston, C., Kuruppu, S., Kneisz, D., Maduwage, K., Kleifeld, O., Smith, A. I., Siribaddana, S., Buckley, N. A., Hodgson, W. C. & Isbister, G. K., 2 Dec 2016, In : PLoS Neglected Tropical Diseases. 10, 12, 18 p., 0005172.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Combining an epithelial repair factor and anti-fibrotic with a corticosteroid offers optimal treatment for allergic airways disease

Patel, K. P., Giraud, A. S., Samuel, C. S. & Royce, S. G., 2016, In : British Journal of Pharmacology. 173, 12, p. 2016 - 2029 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Comparison of sympathetic nerve activity normalization procedures in conscious rabbits

Burke, S. L., Lim, K., Moretti, J-L. & Head, G. A., 1 May 2016, In : American Journal of Physiology - Heart and Circulatory Physiology. 310, 9, p. H1222-H1232 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Compound 21, a selective agonist of angiotensin AT2 receptors, prevents endothelial inflammation and leukocyte adhesion in vitro and in vivo

Sampson, A. K., Irvine, J. C., Shihata, W. A., Dragoljevic, D., Lumsden, N., Huet, O., Barnes, T., Unger, T., Steckelings, U. M., Jennings, G. L., Widdop, R. E. & Chin-Dusting, J. P. F., 1 Feb 2016, In : British Journal of Pharmacology. 173, 4, p. 729-740 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Contribution of Orexin to the neurogenic hypertension in BPH/2J mice

Jackson, K. L., Dampney, B. W., Moretti, J-L., Stevenson, E. R., Davern, P. J., Carrive, P. & Head, G. A., May 2016, In : Journal of Hypertension. 67, 5, p. 959-969 11 p.

Research output: Contribution to journalArticleResearchpeer-review

CORRIGENDUM: N-terminal domain of Bothrops asper Myotoxin II Enhances the Activity of Endothelin Converting Enzyme-1 and Neprilysin

Smith, A. I., Rajapakse, N. W., Kleifeld, O., Lomonte, B., Sikanyika, N. L., Spicer, A. J., Hodgson, W. C., Conroy, P., Small, D. H., Kaye, D. M., Parkington, H. C., Whisstock, J. & Kuruppu, D. M. S., 2016, In : Scientific Reports. 6, Article # 24333, p. 1 - 1 1 p.

Research output: Contribution to journalArticleOther

Could burning fat start with a brite spark? Pharmacological and nutritional ways to promote thermogenesis

Merlin, J., Evans, B. A., Dehvari, N., Sato, M., Bengtsson, T. & Hutchinson, D. S., 2016, In : Molecular Nutrition and Food Research. 60, 1, p. 18-42 25 p.

Research output: Contribution to journalArticleResearchpeer-review

Cross-neutralisation of in vitro neurotoxicity of asian and Australian snake neurotoxins and venoms by different antivenoms

Silva, A., Hodgson, W. C. & Isbister, G. K., 1 Oct 2016, In : Toxins. 8, 10, 18 p., 302.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Crystal structures of the M1 and M4 muscarinic acetylcholine receptors

Thal, D. M., Sun, B., Feng, D., Nawaratne, V., Leach, K., Felder, C. C., Bures, M. G., Evans, D. A., Weis, W. I., Bachhawat, P., Kobilka, T. S., Sexton, P. M., Kobilka, B. K. & Christopoulos, A., 17 Mar 2016, In : Nature. 531, 7594, p. 335-340 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Decorated self-assembling β3-tripeptide foldamers form cell adhesive scaffolds

Luder, K., Kulkarni, K., Lee, H. W., Widdop, R. E., Del Borgo, M. P. & Aguilar, M-I., 29 Feb 2016, In : Chemical Communications. 52, 24, p. 4549-4552 4 p.

Research output: Contribution to journalArticleResearchpeer-review

Detection of snake venom in post-antivenom samples by dissociation treatment followed by Enzyme Immunoassay

Maduwage, K. P., O’Leary, M. A., Silva, A. & Isbister, G. K., 1 May 2016, In : Toxins. 8, 5, 9 p., 130.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Distribution and trafficking of the μ-opioid receptor in enteric neurons of the guinea pig

Lay, J., Carbone, S. E., Dicello, J. J., Bunnett, N., Canals, M. & Poole, D. P., 1 Aug 2016, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 311, 2, p. G252-G266 15 p.

Research output: Contribution to journalArticleResearchpeer-review

Effect of Endothelin-1 on Baroreflexes and the Cardiovascular Action of Clonidine in Conscious Rabbits

Lim, K., van den Buuse, M. & Head, G. A., 28 Jul 2016, In : Frontiers in Physiology. 7, JUL, 9 p., 00321.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Effects of animal venoms and toxins on hallmarks of cancer

Chaisakul, J., Hodgson, W. C., Kuruppu, S. & Prasongsook, N., 15 Jul 2016, In : Journal of Cancer. 7, 11, p. 1571-1578 8 p.

Research output: Contribution to journalReview ArticleOtherpeer-review

Efficacy of Indian polyvalent snake antivenoms against Sri Lankan snake venoms: lethality studies or clinically focussed in vitro studies

Maduwage, K., Silva, A., O'Leary, M. A., Hodgson, W. C. & Isbister, G. K., 27 May 2016, In : Scientific Reports. 6, 11 p., 26778.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File

Efficacy of intravenous hydrocortisone administered 2–4 h prior to antivenom as prophylaxis against adverse drug reactions to snake antivenom in Sri Lanka: An open labelled randomized controlled trial

Kularatne, S. A. M., Weerakoon, K., Silva, A., Maduwage, K., Walathara, C., Rathnayake, I., Medagedara, S., Paranagama, R., Mendis, S. & Kumarasiri, P. V. R., 15 Sep 2016, In : Toxicon : official journal of the International Society on Toxinology. 120, p. 159-165 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Engineering of a novel simplified human insulin-like peptide 5 agonist

Patil, N. A., Hughes, R. A., Rosengren, K. J., Kocan, M., Ang, S. Y., Tailhades, J., Separovic, F., Summers, R. J., Grosse, J., Wade, J., Bathgate, R. A. D. & Hossain, M. A., 10 Mar 2016, In : Journal of Medicinal Chemistry. 59, 5, p. 2118-2125 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Enhanced serelaxin signalling in co-cultures of human primary endothelial and smooth muscle cells

Sarwar, M., Samuel, C. S., Bathgate, R., Stewart, D. R. & Summers, R. J., 2016, In : British Journal of Pharmacology. 173, 3, p. 484 - 496 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Erratum: Multiphoton imaging reveals a new leukocyte recruitment paradigm in the glomerulus (Nature Medicine (2013) 19 (107-112))

Devi, S., Li, A., Westhorpe, C. L. V., Lo, C. Y., Abeynaike, L. D., Snelgrove, S. L., Hall, P., Ooi, J. D., Sobey, C. G., Kitching, A. R. & Hickey, M. J., 6 Apr 2016, In : Nature Medicine. 22, 4, p. 446 1 p.

Research output: Contribution to journalComment / DebateOtherpeer-review

Estrogens do not protect, but androgens exacerbate, collagen accumulation in the female mouse kidney after ureteric obstruction

Hewitson, T. D., Boon, W. C., Simpson, E. R., Smith, E. R. & Samuel, C. S., 1 Aug 2016, In : Life Sciences. 158, p. 130-136 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Evidence of CCR2-independent transmigration of Ly6Chi monocytes into the brain after permanent cerebral ischemia in mice

Chu, H. X., Kim, H. A., Lee, S., Broughton, B. R. S., Drummond, G. R. & Sobey, C. G., 15 Apr 2016, In : Brain Research. 1637, p. 118-127 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Extracellular loop 2 of the adenosine A1 receptor has a key role in orthosteric ligand affinity and agonist efficacy

Nguyen, A. T. N., Baltos, J-A., Thomas, T., Nguyen, T. D., Lopez Munoz, L., Gregory, K. J., White, P. J., Sexton, P. M., Christopoulos, A. & May, L. T., 1 Dec 2016, In : Molecular Pharmacology. 90, 6, p. 703-714 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Ghrelin-related peptides do not modulate vasodilator nitric oxide production or superoxide levels in mouse systemic arteries

Ku, J. M., Sleeman, M. W., Sobey, C. G., Andrews, Z. B. & Miller, A. A., Apr 2016, In : Clinical and Experimental Pharmacology and Physiology. 43, 4, p. 468-475 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Glucagon-like peptide-1 and its class B G protein-coupled receptors: a long march to therapeutic successes

de Graaf, C., Donnelly, D., Wootten, D., Lau, J., Sexton, P. M., Miller, L. J., Ahn, J-M., Liao, J., Fletcher, M. M., Yang, D., Brown, A. J. H., Zhou, C., Deng, J. & Wang, M-W., 1 Oct 2016, In : Pharmacological Reviews. 68, 4, p. 954-1013 60 p.

Research output: Contribution to journalArticleResearchpeer-review

Glucose-6-phosphate dehydrogenase contributes to the regulation of glucose uptake in skeletal muscle

Lee-Young, R. S., Hoffman, N. J., Murphy, K. T., Henstridge, D. C., Samocha-Bonet, D., Siebel, A. L., Iliades, P., Zivanovic, B., Hong, Y. H., Colgan, T. D., Kraakman, M. J., Bruce, C. R., Gregorevic, P., McConell, G. K., Lynch, G. S., Drummond, G. R., Kingwell, B. A., Greenfield, J. R. & Febbraio, M. A., 1 Nov 2016, In : Molecular Metabolism. 5, 11, p. 1083-1091 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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G protein coupled receptor 18: a potential role for endocannabinoid signaling in metabolic dysfunction

Rajaraman, G., Simcocks, A., Hryciw, D. H., Hutchinson, D. S. & McAinch, A. J., 1 Jan 2016, In : Molecular Nutrition and Food Research. 60, 1, p. 92-102 11 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

G protein-coupled receptor trafficking and signalling in the enteric nervous system: the past, present and future

Poole, D. P. & Bunnett, N. W., 2016, The Enteric Nervous System: 30 Years Later. Brierley, S. & Costa, M. (eds.). Springer, p. 145-152 8 p. (Advances in Experimental Medicine and Biology; vol. 891).

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Otherpeer-review