Research Output

2017
7 Citations (Scopus)

Neurokinin 1 receptor signaling in endosomes mediates sustained nociception and is a viable therapeutic target for prolonged pain relief

Jensen, D. D., Lieu, T., Halls, M. L., Veldhuis, N. A., Imlach, W. L., Mai, Q. N., Poole, D. P., Quach, T., Aurelio, L., Conner, J., Klein Herenbrink, C., Barlow, N., Simpson, J. S., Scanlon, M. J., Graham, B., McCluskey, A., Robinson, P. J., Escriou, V., Nassini, R., Materazzi, S. & 6 others, Geppetti, P., Hicks, G. A., Christie, M. J., Porter, C. J. H., Canals, M. & Bunnett, N. W., 31 May 2017, In : Science Translational Medicine. 9, 392, 15 p., aal3447.

Research output: Contribution to journalArticleResearchpeer-review

52 Citations (Scopus)

Neurotoxicity in Sri Lankan Russell’s Viper (Daboia russelii) Envenoming is Primarily due to U1-viperitoxin-Dr1a, a Pre-Synaptic Neurotoxin

Silva, A., Kuruppu, S., Othman, I., Goode, R. J. A., Hodgson, W. C. & Isbister, G. K., Jan 2017, In : Neurotoxicity Research. 31, 1, p. 11-19 9 p.

Research output: Contribution to journalArticleResearchpeer-review

19 Citations (Scopus)

Neutrophil-derived S100 calcium-binding proteins A8/A9 promote reticulated thrombocytosis and atherogenesis in diabetes

Kraakman, M. J., Lee, M. K. S., Al-Sharea, A., Dragoljevic, D., Barrett, T. J., Montenont, E., Basu, D., Heywood, S. E., Kammoun, H. L., Flynn, M., Whillas, A., Hanssen, N. M. J., Febbraio, M. A., Westein, E., Fisher, E. A., Chin-Dusting, J., Cooper, M. E., Berger, J. S., Goldberg, I. J., Nagareddy, P. R. & 1 others, Murphy, A. J., 1 Jun 2017, In : Journal of Clinical Investigation. 127, 6, p. 2133-2147 15 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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57 Citations (Scopus)

Nicotinic acetylcholine receptor alpha 7 stimulation dampens splenic myelopoiesis and inhibits atherogenesis in Apoe−/− mice

Al-Sharea, A., Lee, M. K. S., Whillas, A., Flynn, M. C., Chin-Dusting, J. & Murphy, A. J., 1 Oct 2017, In : Atherosclerosis. 265, p. 47-53 7 p.

Research output: Contribution to journalArticleResearchpeer-review

7 Citations (Scopus)

Novel approaches for treating hypertension

Freeman, A. J., Vinh, A. & Widdop, R. E., 27 Jan 2017, In : F1000Research. 6, 7 p., 80.

Research output: Contribution to journalReview ArticleResearchpeer-review

Open Access
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3 Citations (Scopus)

PB1-F2 peptide derived from avian influenza A virus H7N9 induces inflammation via activation of the NLRP3 inflammasome

Pinar, A., Dowling, J. K., Bitto, N. J., Robertson, A. A. B., Latz, E., Stewart, C. R., Drummond, G. R., Cooper, M. A., McAuley, J. L., Tate, M. D. & Mansell, A., 20 Jan 2017, In : The Journal of Biological Chemistry. 292, 3, p. 826-836 11 p.

Research output: Contribution to journalArticleResearchpeer-review

37 Citations (Scopus)

Phase-plate cryo-EM structure of a class B GPCR-G-protein complex

Liang, Y-L., Khoshouei, M., Radjainia, M., Zhang, Y., Glukhova, A., Tarrasch, J., Thal, D., Furness, S. G. B., Christopoulos, G., Coudrat, T., Danev, R., Baumeister, W., Miller, L. J., Christopoulos, A., Kobilka, B., Wootten, D., Skiniotis, G. & Sexton, P., 1 Jun 2017, In : Nature. 546, 7656, p. 118-123 6 p.

Research output: Contribution to journalArticleResearchpeer-review

237 Citations (Scopus)

Positive allosteric modulation of GABAA receptors attenuates high blood pressure in Schlager hypertensive mice

Stevenson, E. R., Johns, E. M. C., Marques, F. Z., Jackson, K. L., Davern, P. J., Evans, R. G. & Head, G. A., Mar 2017, In : Journal of Hypertension. 35, 3, p. 546-557 12 p.

Research output: Contribution to journalArticleResearchpeer-review

3 Citations (Scopus)

Potent neuroprotection after stroke afforded by a double-knot spider-venom peptide that inhibits acid-sensing ion channel 1a

Chassagnon, I. R., McCarthy, C. A., Chin, Y. K. Y., Pineda, S. S., Keramidas, A., Mobli, M., Pham, V., De Silva, T. M., Lynch, J. W., Widdop, R. E., Rash, L. D. & King, G. F., 4 Apr 2017, In : Proceedings of the National Academy of Sciences of the United States of America. 114, 14, p. 3750-3755 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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62 Citations (Scopus)

Precise control of drug loading and release of an NSAID-polymer conjugate for long term osteoarthritis intra-articular drug delivery

Sulistio, A., Reyes-Ortega, F., D'Souza, A. M., Ng, S. M. Y., Valade, D., Quinn, J. F., Donohue, A. C., Mansfeld, F., Blencowe, A., Qiao, G., Prankerd, R., Quirk, S., Whittaker, M. R., Davis, T. P. & Tait, R. J., 1 Jan 2017, In : Journal of Materials Chemistry B. 5, 31, p. 6221-6226 6 p.

Research output: Contribution to journalArticleResearchpeer-review

5 Citations (Scopus)

Pressor response to angiotensin II is enhanced in aged mice and associated with inflammation, vasoconstriction and oxidative stress

Dinh, Q. N., Drummond, G. R., Kemp-Harper, B. K., Diep, H., De Silva, T. M., Kim, H. A., Vinh, A., Robertson, A. A. B., Cooper, M. A., Mansell, A., Chrissobolis, S. & Sobey, C. G., 28 Jun 2017, In : Aging. 9, 6, p. 1595-1605 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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18 Citations (Scopus)

Recent progress in the understanding of relaxin family peptides and their receptors

Summers, R. J., 2017, In : British Journal of Pharmacology. 174, 10, p. 915-920 6 p.

Research output: Contribution to journalEditorialOtherpeer-review

Redefining Academic Identity in an Evolving Higher Education Landscape

Flecknoe, S. J., Choate, J. K., Davis, E. A., Hodgson, Y. M., Johanesen, P. A., Macaulay, J. O., Murphy, K., Sturrock, W. J. & Rayner, G. M., 2017, In : Journal of University Teaching and Learning Practice. 14, 2, 19 p., 2.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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2 Citations (Scopus)

Relaxin contributes to the regulation of arterial pressure in adult female mice

Colafella, K. M. M., Samuel, C. S. & Denton, K. M., 28 Nov 2017, In : Clinical Science. 131, 23, p. 2795-2805 11 p.

Research output: Contribution to journalArticleResearchpeer-review

6 Citations (Scopus)

Signal transduction pathways activated by insulin-like peptide 5 at the relaxin family peptide RXFP4 receptor

Ang, S. Y., Hutchinson, D. S., Patil, N., Evans, B. A., Bathgate, R. A. D., Halls, M. L., Hossain, M. A., Summers, R. J. & Kocan, M., 1 May 2017, In : British Journal of Pharmacology. 174, 10, p. 1077-1089 13 p.

Research output: Contribution to journalArticleResearchpeer-review

15 Citations (Scopus)

Small-molecule-biased formyl peptide receptor agonist compound 17b protects against myocardial ischaemia-reperfusion injury in mice

Qin, C. X., May, L. T., Li, R., Cao, N., Rosli, S., Deo, M., Alexander, A. E., Horlock, D., Bourke, J. E., Yang, Y. H., Stewart, A. G., Kaye, D. M., Du, X. J., Sexton, P. M., Christopoulos, A., Gao, X. M. & Ritchie, R. H., 7 Feb 2017, In : Nature Communications. 8, 13 p., 14232.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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30 Citations (Scopus)

Structural features embedded in G protein-coupled receptor co-crystal structures are key to their success in virtual screening

Coudrat, T., Christopoulos, A., Sexton, P. M. & Wootten, D., 1 Apr 2017, In : PLoS ONE. 12, 4, 29 p., e0174719.

Research output: Contribution to journalArticleResearchpeer-review

File
3 Citations (Scopus)

Structure of the adenosine A1 receptor reveals the basis for subtype selectivity

Glukhova, A., Thal, D. M., Nguyen, A. T., Vecchio, L., Jorg, M., Scammells, P. J., May, L. T., Sexton, P. M. & Christopoulos, A., 23 Feb 2017, In : Cell. 168, 5, p. 867-877.e13

Research output: Contribution to journalArticleResearchpeer-review

105 Citations (Scopus)

Targeting adenosine receptors for the treatment of cardiac fibrosis

Vecchio, E. A., White, P. J. & May, L. T., 5 May 2017, In : Frontiers in Pharmacology. 8, MAY, 7 p., 243.

Research output: Contribution to journalReview ArticleOtherpeer-review

Open Access
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17 Citations (Scopus)

The actions of relaxin family peptides on signal transduction pathways activated by the relaxin family peptide receptor RXFP4

Ang, S. Y., Hutchinson, D. S., Evans, B. A., Hossain, M. A., Patil, N., Bathgate, R. A. D., Kocan, M. & Summers, R. J., Jan 2017, In : Naunyn-Schmiedeberg's Archives of Pharmacology. 390, 1, p. 105-111 7 p.

Research output: Contribution to journalArticleResearchpeer-review

4 Citations (Scopus)

The actions of relaxin on the human cardiovascular system

Sarwar, M., Du, X. J., Dschietzig, T. B. & Summers, R. J., 1 May 2017, In : British Journal of Pharmacology. 174, 10, p. 933-949 17 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

28 Citations (Scopus)

The Bold and the Beautiful: a Neurotoxicity Comparison of New World Coral Snakes in the Micruroides and Micrurus Genera and Relative Neutralization by Antivenom

Yang, D. C., Dobson, J., Cochran, C., Dashevsky, D., Arbuckle, K., Benard, M., Boyer, L., Alagón, A., Hendrikx, I., Hodgson, W. C. & Fry, B. G., Oct 2017, In : Neurotoxicity Research. 32, 3, p. 487-495 9 p.

Research output: Contribution to journalArticleResearchpeer-review

10 Citations (Scopus)

The cardiovascular and neurotoxic effects of the venoms of six bony and cartilaginous fish species

Han, H., Baumann, K., Casewell, N. R., Ali, S. A., Dobson, J., Koludarov, I., Debono, J., Cutmore, S. C., Rajapakse, N. W., Jackson, T. N. W., Jones, R., Hodgson, W. C., Fry, B. G. & Kuruppu, S., 16 Feb 2017, In : Toxins. 9, 2, 10 p., 67.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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3 Citations (Scopus)

THE CONCISE GUIDE TO PHARMACOLOGY 2017/18: Overview

Alexander, S. P. H., Kelly, E., Marrion, N. V., Peters, J. A., Faccenda, E., Harding, S. D., Pawson, A. J., Sharman, J. L., Southan, C., Buneman, O. P., Cidlowski, J. A., Christopoulos, A., Davenport, A. P., Fabbro, D., Spedding, M., Striessnig, J., Davies, J. A. & CGTP Collaborators, 1 Dec 2017, In : British Journal of Pharmacology. 174, S1, p. S1-S16 16 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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156 Citations (Scopus)

The effect of tocopheryl phosphates (TPM) on the development of atherosclerosis in apolipoprotein-E deficient mice

Libinaki, R., Vinh, A., Tesanovic-Klajic, S., Widdop, R. & Gaspari, T., 1 Dec 2017, In : Clinical and Experimental Pharmacology and Physiology. 44, S1, p. 107-116 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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9 Citations (Scopus)

The Evolution of Fangs, Venom, and Mimicry Systems in Blenny Fishes

Casewell, N. R., Visser, J. C., Baumann, K., Dobson, J., Han, H., Kuruppu, S., Morgan, M., Romilio, A., Weisbecker, V., Ali, S. A., Debono, J., Koludarov, I., Que, I., Bird, G. C., Cooke, G. M., Nouwens, A. S., Hodgson, W. C., Wagstaff, S. C., Cheney, K. L., Vetter, I. & 3 others, van der Weerd, L., Richardson, M. K. & Fry, B. G., 24 Apr 2017, In : Current Biology. 27, 8, p. 1184-1191 8 p.

Research output: Contribution to journalArticleResearchpeer-review

21 Citations (Scopus)

The importance and prognostic value of nocturnal blood pressure assessments using inexpensive domestic devices

Head, G. A., 2017, In : Journal of Hypertension. 35, 3, p. 463-465 3 p.

Research output: Contribution to journalComment / DebateOtherpeer-review

5 Citations (Scopus)

The opposing roles of NO and oxidative stress in cardiovascular disease

Ritchie, R. H., Drummond, G. R., Sobey, C. G., De Silva, T. M. & Kemp-Harper, B. K., Feb 2017, In : Pharmacological Research. p. 57-69 13 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

36 Citations (Scopus)

Ticks from diverse genera encode chemokine-inhibitory evasin proteins

Hayward, J., Sanchez, J., Perry, A., Huang, C., Rodriguez Valle, M., Canals, M., Payne, R. J. & Stone, M. J., 22 Sep 2017, In : The Journal of Biological Chemistry. 292, 38, p. 15670-15680 11 p.

Research output: Contribution to journalArticleResearchpeer-review

18 Citations (Scopus)

Treatment with an interleukin-1 receptor antagonist mitigates neuroinflammation and brain damage after polytrauma

Sun, M., Brady, R. D., Wright, D. K., Kim, H. A., Zhang, S. R., Sobey, C. G., Johnstone, M. R., O'Brien, T. J., Semple, B. D., McDonald, S. J. & Shultz, S. R., Nov 2017, In : Brain, Behavior, and Immunity. 66, p. 359-371 13 p.

Research output: Contribution to journalArticleResearchpeer-review

30 Citations (Scopus)

Vasoactive actions of nitroxyl (HNO) are preserved in resistance arteries in diabetes

Tare, M., Kalidindi, R. S. R., Bubb, K. J., Parkington, H. C., Boon, W-M., Li, X., Sobey, C. G., Drummond, G. R., Ritchie, R. H. & Kemp-Harper, B. K., Apr 2017, In : Naunyn-Schmiedeberg's Archives of Pharmacology. 390, 4, p. 397-408 12 p.

Research output: Contribution to journalArticleResearchpeer-review

4 Citations (Scopus)

What determines the magnitude of cellular response for activation of G protein-coupled receptors?

Furness, S. G. B., Wootten, D. & Sexton, P. M., 6 Feb 2017, In : Cell Cycle. 16, 5, p. 392-394 3 p.

Research output: Contribution to journalEditorialOtherpeer-review

2016

4-phenylpyridin-2-one derivatives: a novel class of positive allosteric modulator of the M1 muscarinic acetylcholine receptor

Mistry, S. N., Jorg, M., Lim, H., Vinh, N. B., Sexton, P. M., Capuano, B., Christopoulos, A., Lane, J. R. & Scammells, P. J., 14 Jan 2016, In : Journal of Medicinal Chemistry. 59, 1, p. 388-409 22 p.

Research output: Contribution to journalArticleResearchpeer-review

25 Citations (Scopus)

Accelerated structure-based design of chemically diverse allosteric modulators of a muscarinic G protein-coupled receptor

Miao, Y., Goldfeld, D. A., Moo, E. V., Sexton, P. M., Christopoulos, A., McCammon, J. A. & Valant, C., 20 Sep 2016, In : Proceedings of the National Academy of Sciences of the United States of America. 113, 38, p. E5675-E5684 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
47 Citations (Scopus)

Adverse vascular remodelling is more sensitive than endothelial dysfunction to hyperglycaemia in diabetic rat mesenteric arteries

Kahlberg, N., Qin, C. X., Anthonisz, J., Jap, E., Ng, H. H., Jelinic, M., Parry, L. J., Kemp-Harper, B. K., Ritchie, R. H. & Leo, C. H., 1 Sep 2016, In : Pharmacological Research. 111, p. 325-335 11 p.

Research output: Contribution to journalArticleResearchpeer-review

13 Citations (Scopus)

A hydrogen-bonded polar network in the core of the glucagon-like peptide-1 receptor is a fulcrum for biased agonism: lessons from class B crystal structuress

Wootten, D., Reynolds, C. A., Koole, C., Smith, K. J., Mobarec, J. C., Simms, J., Quon, T., Coudrat, T., Furness, S. G. B., Miller, L. J., Christopoulos, A. & Sexton, P. M., 1 Mar 2016, In : Molecular Pharmacology. 89, 3, p. 335-347 13 p.

Research output: Contribution to journalArticleResearchpeer-review

30 Citations (Scopus)

Airway remodeling and hyperreactivity in a model of bronchopulmonary dysplasia and their modulation by IL-1Ra

Royce, S. G., Nold, M. F., Bui, C. B-Q., Donovan, C., Lam, M., Lamanna, E., Rudloff, I., Bourke, J. E. & Nold-Petry, C. A., 1 Dec 2016, In : American Journal of Respiratory Cell and Molecular Biology. 55, 6, p. 858-868 11 p.

Research output: Contribution to journalArticleResearchpeer-review

16 Citations (Scopus)

Aldosterone-induced oxidative stress and inflammation in the brain are mediated by the endothelial cell mineralocorticoid receptor

Dinh, Q. N., Young, M. J., Evans, M. A., Drummond, G. R., Sobey, C. G. & Chrissobolis, S., 2016, In : Brain Research. 1637, p. 146 - 153 8 p.

Research output: Contribution to journalArticleResearchpeer-review

32 Citations (Scopus)

Allosteric Modulation as a Unifying Mechanism for Receptor Function and Regulation

Changeux, J. P. & Christopoulos, A., 25 Aug 2016, In : Cell. 166, 5, p. 1084-1102 19 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

99 Citations (Scopus)

An allosteric role for receptor activity-modifying proteins in defining GPCR pharmacology

Gingell, J. J., Simms, J., Barwell, J., Poyner, D., Watkins, H. A., Pioszak, A. A., Sexton, P. M. & Hay, D., 17 May 2016, In : Cell Discovery. 2, 14 p., 16012.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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28 Citations (Scopus)

Angiotensin AT2-receptor stimulation improves survival and neurological outcome after experimental stroke in mice

Schwengel, K., Namsolleck, P., Lucht, K., Clausen, B. H., Lambertsen, K. L., Valero-Esquitino, V., Thone-Reineke, C., Müller, S., Widdop, R. E., Denton, K. M., Horiuchi, M., Iwai, M., Boato, F., Dahlof, B., Hallberg, A., Unger, T. & Steckelings, U. M., Aug 2016, In : Journal of Molecular Medicine. 94, 8, p. 957-966 10 p.

Research output: Contribution to journalArticleResearchpeer-review

20 Citations (Scopus)

Antagonism of the proinflammatory and pronociceptive actions of canonical and biased agonists of protease-activated receptor-2

Lieu, T., Savage, E., Zhao, P., Edgington-Mitchell, L., Barlow, N., Bron, R., Poole, D. P., McLean, P., Lohman, R. J., Fairlie, D. P. & Bunnett, N. W., 1 Sep 2016, In : British Journal of Pharmacology. 173, 18, p. 2752-2765 14 p.

Research output: Contribution to journalArticleResearchpeer-review

8 Citations (Scopus)

Antifibrotic actions of Serelaxin: New roles for an old player

Samuel, C. S., Summers, R. J. & Hewitson, T. D., Jun 2016, In : Trends in Pharmacological Sciences. 37, 6, p. 485-497 13 p.

Research output: Contribution to journalReview ArticleOtherpeer-review

22 Citations (Scopus)

Apocynin and ebselen reduce influenza A virus-induced lung inflammation in cigarette smoke-exposed mice

Oostwoud, L. C., Gunasinghe, P., Seow, H. J., Ye, J. M., Selemidis, S., Bozinovski, S. & Vlahos, R., 15 Feb 2016, In : Scientific Reports. 6, 16 p., 20983.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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27 Citations (Scopus)

A single-chain derivative of the relaxin hormone is a functionally selective agonist of the G protein-coupled receptor, RXFP1

Hossain, M. A., Kocan, M., Yao, S. T., Royce, S. G., Nair, V. B., Siwek, C., Patil, N. A., Harrison, I. P., Rosengren, K. J., Selemidis, S., Summers, R. J., Wade, J. D., Bathgate, R. A. D. & Samuel, C. S., 2016, In : Chemical Science. 7, 6, p. 3805-3819 15 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
34 Citations (Scopus)

Cardiac tissue injury and remodeling is dependent upon mr regulation of activation pathways in cardiac tissue macrophages

Shen, J. Z. L., Morgan, J., Tesch, G. H., Rickard, A. J., Chrissobolis, S., Drummond, G. R., Fuller, P. J. & Young, M., 1 Aug 2016, In : Endocrinology. 157, 8, p. 3213-3223 11 p.

Research output: Contribution to journalArticleResearchpeer-review

26 Citations (Scopus)

Caveolae: A role in endothelial inflammation and mechanotransduction?

Shihata, W. A., Michell, D. L., Andrews, K. L. & Chin-Dusting, J. P. F., 20 Dec 2016, In : Frontiers in Physiology. 7, 9 p., 628.

Research output: Contribution to journalReview ArticleResearchpeer-review

Open Access
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21 Citations (Scopus)

Cell-specific mineralocorticoid receptors: Future therapeutic targets for stroke?

Dinh, Q. N., Drummond, G. R., Sobey, C. G. & Chrissobolis, S., 1 Aug 2016, In : Neural Regeneration Research. 11, 8, p. 1230-1231 2 p.

Research output: Contribution to journalComment / DebateOtherpeer-review

Central proopiomelanocortin but not neuropeptide Y mediates sympathoexcitation and hypertension in fat fed conscious rabbits

Barzel, B., Lim, K., Davern, P. J., Burke, S. L., Armitage, J. A. & Head, G. A., Mar 2016, In : Journal of Hypertension. 34, 3, p. 464-473 10 p.

Research output: Contribution to journalArticleResearchpeer-review

6 Citations (Scopus)