Research Output

2018

Vitamin D3 Supplementation Reduces Subsequent Brain Injury and Inflammation Associated with Ischemic Stroke

Evans, M. A., Kim, H. A., Ling, Y. H., Uong, S., Vinh, A., De Silva, T. M., Arumugam, T. V., Clarkson, A. N., Zosky, G. R., Drummond, G. R., Broughton, B. R. S. & Sobey, C. G., 1 Mar 2018, In : NeuroMolecular Medicine. 20, 1, p. 147-159 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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10 Citations (Scopus)

“Selective” class C G protein-coupled receptor modulators are neutral or biased mGlu5 allosteric ligands

Hellyer, S. D., Albold, S., Wang, T., Chen, A. N. Y., May, L. T., Leach, K. & Gregory, K. J., 1 May 2018, In : Molecular Pharmacology. 93, 5, p. 504-514 11 p.

Research output: Contribution to journalArticleResearchpeer-review

7 Citations (Scopus)
2017

Acute effect of central administration of urotensin II on baroreflex and blood pressure in conscious normotensive rabbits

Lim, K., Sata, Y., Jackson, K. L., Burke, S. L. & Head, G. A., 23 Feb 2017, In : Frontiers in Physiology. 8, FEB, 9 p., 110.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Adenylyl cyclase signalling complexes - pharmacological challenges and opportunities

Halls, M. L. & Cooper, D. M. F., Apr 2017, In : Pharmacology and Therapeutics. 172, p. 171-180 10 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

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22 Citations (Scopus)

Adrenoceptors promote glucose uptake into adipocytes and muscle by an insulin-independent signaling pathway involving mechanistic target of rapamycin complex 2

Mukaida, S., Evans, B. A., Bengtsson, T., Hutchinson, D. S. & Sato, M., 1 Feb 2017, In : Pharmacological Research. 116, p. 87-92 6 p.

Research output: Contribution to journalArticleResearchpeer-review

11 Citations (Scopus)

Advanced atherosclerosis is associated with inflammation, vascular dysfunction and oxidative stress, but not hypertension

Dinh, Q. N., Chrissobolis, S., Diep, H., Chan, C. T., Ferens, D., Drummond, G. R. & Sobey, C. G., Feb 2017, In : Pharmacological Research. p. 70-76 7 p.

Research output: Contribution to journalArticleResearchpeer-review

12 Citations (Scopus)

Airway remodelling and inflammation in asthma are dependent on the extracellular matrix protein fibulin-1c

Liu, G., Cooley, M. A., Nair, P. M., Donovan, C., Hsu, A. C., Jarnicki, A. G., Haw, T. J., Hansbro, N. G., Ge, Q., Brown, A. C., Tay, H., Foster, P. S., Wark, P. A., Horvat, J. C., Bourke, J. E., Grainge, C. L., Argraves, W. S., Oliver, B. G., Knight, D. A., Burgess, J. K. & 1 others, Hansbro, P. M., 1 Dec 2017, In : Journal of Pathology. 243, 4, p. 510-523 14 p.

Research output: Contribution to journalArticleResearchpeer-review

24 Citations (Scopus)

A kinetic view of GPCR allostery and biased agonism

Lane, J. R., May, L. T., Parton, R. G., Sexton, P. M. & Christopoulos, A., 18 Aug 2017, In : Nature Chemical Biology. 13, 9, p. 929-937 9 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

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53 Citations (Scopus)

Allosteric modulation as a unifying mechanism for receptor function and regulation

Changeux, J-P. & Christopoulos, A., 1 Sep 2017, In : Diabetes, Obesity and Metabolism. 19, p. 4-21 18 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

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17 Citations (Scopus)

Allostery and Biased Agonism at Class B G Protein-Coupled Receptors

Wootten, D., Miller, L. J., Koole, C., Christopoulos, A. & Sexton, P. M., 11 Jan 2017, In : Chemical Reviews. 117, 1, p. 111-138 28 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

41 Citations (Scopus)

Amyloidogenicity at a Distance: How Distal Protein Regions Modulate Aggregation in Disease

Lucato, C. M., Lupton, C. J., Halls, M. L. & Ellisdon, A. M., 5 May 2017, In : Journal of Molecular Biology. 429, 9, p. 1289-1304 16 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

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7 Citations (Scopus)

Anakinra reduces blood pressure and renal fibrosis in one kidney/DOCA/salt-induced hypertension

Ling, Y. H., Krishnan, S. M., Chan, C. T., Diep, H., Ferens, D., Chin-Dusting, J., Kemp-Harper, B. K., Samuel, C. S., Hewitson, T. D., Latz, E., Mansell, A., Sobey, C. G. & Drummond, G. R., Feb 2017, In : Pharmacological Research. 116, p. 77-86 10 p.

Research output: Contribution to journalArticleResearchpeer-review

11 Citations (Scopus)

Anti-fibrotic actions of relaxin

Samuel, C. S., Royce, S. G., Hewitson, T. D., Denton, K. M., Cooney, T. E. & Bennett, R. G., 1 May 2017, In : British Journal of Pharmacology. 174, 10, p. 962-976 15 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

44 Citations (Scopus)

Anti-fibrotic potential of AT2 receptor agonists

Wang, Y., Del Borgo, M., Lee, H. W., Baraldi, D., Hirmiz, B., Gaspari, T. A., Denton, K. M., Aguilar, M-I., Samuel, C. S. & Widdop, R. E., 31 Aug 2017, In : Frontiers in Pharmacology. 8, 7 p., 564.

Research output: Contribution to journalReview ArticleResearchpeer-review

Open Access
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21 Citations (Scopus)

Antivenom for neuromuscular paralysis resulting from snake envenoming

Silva, A., Hodgson, W. C. & Isbister, G. K., 19 Apr 2017, In : Toxins. 9, 4, 17 p., 143.

Research output: Contribution to journalReview ArticleResearchpeer-review

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12 Citations (Scopus)

Antivenom for snake venom-induced neuromuscular paralysis

Silva, A., Maduwage, K., Buckley, N. A., Lalloo, D. G., de Silva, H. J. & Isbister, G. K., 21 Mar 2017, In : Cochrane Database of Systematic Reviews. 2017, 3, 12 p., CD012604.

Research output: Contribution to journalArticleResearchpeer-review

A pharmacological examination of the cardiovascular effects of Malayan krait (Bungarus candidus) venoms

Chaisakul, J., Ahmad Rusmili, M. R., Hodgson, W. C., Hatthachote, P., Suwan, K., Inchan, A., Chanhome, L., Othman, I. & Chootip, K., 29 Mar 2017, In : Toxins. 9, 4, 11 p., 122.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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7 Citations (Scopus)

Apolipoprotein A-I Mimetic Peptides: Discordance between in Vitro and in Vivo Properties - Brief Report

Ditiatkovski, M., Palsson, J., Chin-Dusting, J., Remaley, A. T. & Sviridov, D., 1 Jul 2017, In : Arteriosclerosis, Thrombosis and Vascular Biology. 37, 7, p. 1301-1306 6 p.

Research output: Contribution to journalArticleResearchpeer-review

9 Citations (Scopus)

A polymorphism in the norepinephrine transporter gene is associated with affective and cardiovascular disease through a microRNA mechanism

Marques, FZ., Eikelis, N., Bayles, R. G., Lambert, EA., Straznicky, N. E., Hering, D., Esler, MD., Head, GA., Barton, DA., Schlaich, MP. & Lambert, GW., 1 Jan 2017, In : Molecular Psychiatry. 22, 1, p. 134-141 8 p.

Research output: Contribution to journalArticleResearchpeer-review

19 Citations (Scopus)

A portrait of the sialyl glycan receptor specificity of the H10 influenza virus hemagglutinin—a picture of an avian virus on the verge of becoming a pandemic?

Schneider, E. K., Li, J. & Velkov, T., 13 Dec 2017, In : Vaccines. 5, 4, 15 p., 51.

Research output: Contribution to journalReview ArticleResearchpeer-review

Open Access
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1 Citation (Scopus)

Assessing the anthelmintic activity of pyrazole-5-carboxamide derivatives against Haemonchus contortus

Jiao, Y., Preston, S., Song, H., Jabbar, A., Liu, Y., Baell, J., Hofmann, A., Hutchinson, D., Wang, T., Koehler, A. V., Fisher, G. M., Andrews, K. T., Laleu, B., Palmer, M. J., Burrows, J. N., Wells, T. N. C., Wang, Q. & Gasser, R. B., 31 May 2017, In : Parasites & Vectors. 10, 1, 272.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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12 Citations (Scopus)

Biased allosteric agonism and modulation of metabotropic glutamate receptor 5: implications for optimizing preclinical neuroscience drug discovery

Sengmany, K., Singh, J., Stewart, G. D., Conn, P. J., Christopoulos, A. & Gregory, K. J., 15 Mar 2017, In : Neuropharmacology. 115, p. 60-72 13 p.

Research output: Contribution to journalArticleResearchpeer-review

23 Citations (Scopus)

Capadenoson, a clinically trialed partial adenosine A1 receptor agonist, can stimulate adenosine A2B receptor biased agonism

Baltos, J-A., Vecchio, E. A., Harris, M. A., Qin, C. X., Ritchie, R. H., Christopoulos, A., White, P. J. & May, L. T., 1 Jul 2017, In : Biochemical Pharmacology. 135, p. 79–89 11 p.

Research output: Contribution to journalArticleResearchpeer-review

17 Citations (Scopus)

Characterization of signal bias at the GLP-1 receptor induced by backbone modification of GLP-1

Hager, M. V., Clydesdale, L., Gellman, S. H., Sexton, P. M. & Wootten, D., 15 Jul 2017, In : Biochemical Pharmacology. 136, p. 99-108 10 p.

Research output: Contribution to journalArticleResearchpeer-review

18 Citations (Scopus)

Coding GPCR-G protein specificity

Furness, S. G. B. & Sexton, P. M., 1 Oct 2017, In : Cell Research. 27, 10, p. 1193-1194 2 p.

Research output: Contribution to journalShort SurveyResearchpeer-review

Open Access
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1 Citation (Scopus)

Coexpressed class B G protein-coupled secretin and GLP-1 receptors self- and cross-associate: impact on pancreatic islets

Harikumar, K. G., Lau, S., Sexton, P. M., Wootten, D. & Miller, L. J., 1 Jun 2017, In : Endocrinology. 158, 6, p. 1685-1700 16 p.

Research output: Contribution to journalArticleResearchpeer-review

6 Citations (Scopus)

Dianthin-30 or gelonin versus monomethyl auristatin E, each configured with an anti-calcitonin receptor antibody, are differentially potent in vitro in high-grade glioma cell lines derived from glioblastoma

Gilabert-Oriol, R., Furness, S. G. B., Stringer, B. W., Weng, A., Fuchs, H., Day, B. W., Kourakis, A., Boyd, A. W., Hare, D. L., Thakur, M., Johns, T. G. & Wookey, P. J., 2017, In : Cancer Immunology Immunotherapy. 66, 9, p. 1217–1228 12 p.

Research output: Contribution to journalArticleResearchpeer-review

6 Citations (Scopus)

Editorial: Novel therapeutic targets and emerging treatments for fibrosis

Samuel, C. S. & Hewitson, T. D., 14 Nov 2017, In : Frontiers in Pharmacology. 8, 3 p., 824.

Research output: Contribution to journalEditorialOtherpeer-review

Open Access
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2 Citations (Scopus)

Endosomal NOX2 oxidase exacerbates virus pathogenicity and is a target for antiviral therapy

To, E. E., Vlahos, R., Luong, R., Halls, M. L., Reading, P. C., King, P. T., Chan, C., Drummond, G. R., Sobey, C. G., Broughton, B. R. S., Starkey, M. R., van der Sluis, R., Lewin, S. R., Bozinovski, S., O'Neill, L. A. J., Quach, T., Porter, C. J. H., Brooks, D. A., O'Leary, J. & Selemidis, S., 1 Dec 2017, In : Nature Communications. 8, 1, 17 p., 69.

Research output: Contribution to journalArticleResearchpeer-review

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37 Citations (Scopus)

Epigenetic modifications to H3K9 in renal tubulointerstitial cells after unilateral ureteric obstruction and TGF-β1 stimulation

Hewitson, T. D., Holt, S. G., Tan, S-J., Wigg, B., Samuel, C. S. & Smith, E. R., 29 May 2017, In : Frontiers in Pharmacology. 8, 15 p., 307.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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18 Citations (Scopus)

Erratum: The Evolution of Fangs, Venom, and Mimicry Systems in Blenny Fishes (Current Biology (2017) 27(8) (1184–191) (S0960982217302695) (10.1016/j.cub.2017.02.067))

Casewell, N. R., Visser, J. C., Baumann, K., Dobson, J., Han, H., Kuruppu, S., Morgan, M., Romilio, A., Weisbecker, V., Mardon, K., Ali, S. A., Debono, J., Koludarov, I., Que, I., Bird, G. C., Cooke, G. M., Nouwens, A. S., Hodgson, W. C., Wagstaff, S. C., Cheney, K. L. & 4 others, Vetter, I., van der Weerd, L., Richardson, M. K. & Fry, B. G., 22 May 2017, In : Current Biology. 27, 10, p. 1549-1550 2 p.

Research output: Contribution to journalComment / DebateOtherpeer-review

1 Citation (Scopus)

Factors influencing biased agonism in recombinant cells expressing the human α1A-adrenoceptor

da Silva Junior, E. D., Sato, M., Merlin, J., Broxton, N., Hutchinson, D. S., Ventura, S., Evans, B. A. & Summers, R. J., 1 Jul 2017, In : British Journal of Pharmacology. 174, 14, p. 2318-2333 16 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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8 Citations (Scopus)

Factors Responsible for Obesity-Related Hypertension

Lim, K., Jackson, K. L., Sata, Y. & Head, G. A., 1 Jul 2017, In : Current Hypertension Reports. 19, 7, 10 p., 53.

Research output: Contribution to journalReview ArticleResearchpeer-review

17 Citations (Scopus)

Fluorescent diphenylphosphonate-based probes for detection of serine protease activity during inflammation

Edgington-Mitchell, L. E., Barlow, N., Aurelio, L., Samha, A., Szabo, M., Graham, B. & Bunnett, N., 15 Jan 2017, In : Bioorganic and Medicinal Chemistry Letters. 27, 2, p. 254-260 7 p.

Research output: Contribution to journalArticleResearchpeer-review

14 Citations (Scopus)

Garlic-inspired trisulfide linkers for thiol-stimulated H2S release

Ercole, F., Whittaker, M. R., Halls, M. L., Boyd, B. J., Davis, T. P. & Quinn, J. F., 2017, In : Chemical Communications. 53, 57, p. 8030-8033 4 p.

Research output: Contribution to journalArticleResearchpeer-review

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14 Citations (Scopus)

G-CSF receptor blockade ameliorates arthritic pain and disease

Lee, M. C., McCubbin, J. A., Christensen, A. D., Poole, D. P., Rajasekhar, P., Lieu, T., Bunnett, N. W., Garcia-Caraballo, S., Erickson, A., Brierley, S. M., Saleh, R., Achuthan, A., Fleetwood, A. J., Anderson, R. L., Hamilton, J. A. & Cook, A. D., 1 May 2017, In : Journal of Immunology. 198, 9, p. 3565-3575 11 p.

Research output: Contribution to journalArticleResearchpeer-review

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12 Citations (Scopus)

Genetically encoded photocross-linkers determine the biological binding site of exendin-4 peptide in the N-terminal domain of the intact human glucagon-like peptide-1 receptor (GLP-1R)

Koole, C., Reynolds, C. A., Mobarec, J. C., Hick, C., Sexton, P. M. & Sakmar, T. P., 28 Apr 2017, In : The Journal of Biological Chemistry. 292, 17, p. 7131-7144 14 p.

Research output: Contribution to journalArticleResearchpeer-review

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25 Citations (Scopus)

High throughput, quantitative analysis of human osteoclast differentiation and activity

Diepenhorst, N., Nowell, C., Rueda, P., Henriksen, K., Pierce, T., Cook, A., Pastoureau, P., Sabatini, M., Charman, W., Christopoulos, A., Summers, R., Sexton, P. & Langmead, C., 15 Feb 2017, In : Analytical Biochemistry. 519, p. 51-56 6 p.

Research output: Contribution to journalArticleResearchpeer-review

2 Citations (Scopus)

How the cobra got its flesh-eating venom: Cytotoxicity as a defensive innovation and its co-evolution with hooding, aposematic marking, and spitting

Panagides, N., Jackson, T. N. W., Ikonomopoulou, M. P., Arbuckle, K., Pretzler, R., Yang, D. C., Ali, S. A., Koludarov, I., Dobson, J., Sanker, B., Asselin, A., Santana, R. C., Hendrikx, I., van der Ploeg, H., Tai-A-Pin, J., van den Bergh, R., Kerkkamp, H. M. I., Vonk, F. J., Naude, A., Strydom, M. A. & 6 others, Jacobsz, L., Dunstan, N., Jaeger, M., Hodgson, W. C., Miles, J. & Fry, B. G., 13 Mar 2017, In : Toxins. 9, 3, 22 p., 103.

Research output: Contribution to journalArticleResearchpeer-review

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33 Citations (Scopus)

Improving virtual screening of G protein-coupled receptors via ligand-directed modeling

Coudrat, T., Simms, J., Christopoulos, A., Wootten, D. & Sexton, P. M., 1 Nov 2017, In : PLoS Computational Biology. 13, 11, 40 p., e1005819.

Research output: Contribution to journalArticleResearchpeer-review

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5 Citations (Scopus)

Inhibition of the KCa3.1 channel alleviates established pulmonary fibrosisin a large animal model

Organ, L., Bacci, B., Koumoundouros, E., Kimpton, W. G., Samuel, C. S., Nowell, C. J., Bradding, P., Roach, K. M., Westall, G., Jaffar, J. & Snibson, K. J., 1 Apr 2017, In : American Journal of Respiratory Cell and Molecular Biology. 56, 4, p. 539-550 13 p.

Research output: Contribution to journalArticleResearchpeer-review

11 Citations (Scopus)
13 Citations (Scopus)

Isoform-specific biased agonism of histamine H3 receptor agonists

Riddy, D. M., Cook, A. E., Diepenhorst, N. A., Bosnyak, S., Brady, R., La Cour, C. M., Mocaer, E., Summers, R. J., Charman, W. N., Sexton, P. M., Christopoulos, A. & Langmead, C. J., 1 Feb 2017, In : Molecular Pharmacology. 91, 2, p. 87-99 13 p.

Research output: Contribution to journalArticleResearchpeer-review

11 Citations (Scopus)

Key determinants of selective binding and activation by the monocyte chemoattractant proteins at the chemokine receptor CCR2

Huma, Z. E., Sanchez, J., Lim, H. D., Bridgford, J. L., Huang, C., Parker, B. J., Pazhamalil, J. G., Porebski, B. T., Pfleger, K. D. G., Lane, J. R., Canals, M. & Stone, M. J., 23 May 2017, In : Science Signaling. 10, 480, 13 p., eaai8529.

Research output: Contribution to journalArticleResearchpeer-review

17 Citations (Scopus)

Latrophilin receptors: Novel bronchodilator targets in asthma

Faiz, M. A., Donovan, C., Nieuwenhuis, M. A. E., Van Den Berge, M., Postma, D. S., Yao, S., Park, C. Y., Hirsch, R., Fredberg, J. J., Tjin, G., Halayko, A. J., Rempel, K. L., Ward, J. P. T., Lee, T., Bossé, Y., Nickle, D. C., Obeidat, M., Vonk, J. M., Black, J. L., Oliver, B. G. & 4 others, Krishnan, R., McParland, B., Bourke, J. E. & Burgess, J. K., 1 Jan 2017, In : Thorax. 72, 1, p. 74-82 9 p.

Research output: Contribution to journalArticleResearchpeer-review

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6 Citations (Scopus)

Lung health in a changing world

Peters, M. J. & Bourke, J. E., 20 Nov 2017, In : The Medical Journal of Australia. 207, 10, p. 426-428 3 p.

Research output: Contribution to journalEditorialOtherpeer-review

M1 muscarinic allosteric modulators slow prion neurodegeneration and restore memory loss

Bradley, S. J., Bourgognon, J. M., Sanger, H. E., Verity, N., Mogg, A. J., White, D. J., Butcher, A. J., Moreno, J. A., Molloy, C., Macedo-Hatch, T., Edwards, J. M., Wess, J., Pawlak, R., Read, D. J., Sexton, P. M., Broad, L. M., Steinert, J. R., Mallucci, G. R., Christopoulos, A., Felder, C. C. & 1 others, Tobin, A. B., 1 Feb 2017, In : Journal of Clinical Investigation. 127, 2, p. 487-499 13 p.

Research output: Contribution to journalArticleResearchpeer-review

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27 Citations (Scopus)

ML290 is a biased allosteric agonist at the relaxin receptor RXFP1

Kocan, M., Sarwar, M., Ang, S. Y., Xiao, J., Marugan, J., Hossain, M. A., Wang, C., Hutchinson, D. S., Samuel, C. S., Agoulnik, A. I., Bathgate, R. A. D. & Summers, R. J., 1 Dec 2017, In : Scientific Reports. 7, 1, 14 p., 2968.

Research output: Contribution to journalArticleResearchpeer-review

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17 Citations (Scopus)

Molecular insights into allosteric modulation of Class C G protein-coupled receptors

Leach, K. & Gregory, K. J., 1 Feb 2017, In : Pharmacological Research. 116, p. 105-118 14 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

28 Citations (Scopus)