Research Output 1986 2019

2017

Structural features embedded in G protein-coupled receptor co-crystal structures are key to their success in virtual screening

Coudrat, T., Christopoulos, A., Sexton, P. M. & Wootten, D., 1 Apr 2017, In : PLoS ONE. 12, 4, 29 p., e0174719.

Research output: Contribution to journalArticleResearchpeer-review

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Structure of the adenosine A1 receptor reveals the basis for subtype selectivity

Glukhova, A., Thal, D. M., Nguyen, A. T., Vecchio, L., Jorg, M., Scammells, P. J., May, L. T., Sexton, P. M. & Christopoulos, A., 23 Feb 2017, In : Cell. 168, 5, p. 867-877.e13

Research output: Contribution to journalArticleResearchpeer-review

Targeting adenosine receptors for the treatment of cardiac fibrosis

Vecchio, E. A., White, P. J. & May, L. T., 5 May 2017, In : Frontiers in Pharmacology. 8, MAY, 7 p., 243.

Research output: Contribution to journalReview ArticleOtherpeer-review

Open Access
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The actions of relaxin family peptides on signal transduction pathways activated by the relaxin family peptide receptor RXFP4

Ang, S. Y., Hutchinson, D. S., Evans, B. A., Hossain, M. A., Patil, N., Bathgate, R. A. D., Kocan, M. & Summers, R. J., Jan 2017, In : Naunyn-Schmiedeberg's Archives of Pharmacology. 390, 1, p. 105-111 7 p.

Research output: Contribution to journalArticleResearchpeer-review

The actions of relaxin on the human cardiovascular system

Sarwar, M., Du, X. J., Dschietzig, T. B. & Summers, R. J., 1 May 2017, In : British Journal of Pharmacology. 174, 10, p. 933-949 17 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

The Bold and the Beautiful: a Neurotoxicity Comparison of New World Coral Snakes in the Micruroides and Micrurus Genera and Relative Neutralization by Antivenom

Yang, D. C., Dobson, J., Cochran, C., Dashevsky, D., Arbuckle, K., Benard, M., Boyer, L., Alagón, A., Hendrikx, I., Hodgson, W. C. & Fry, B. G., Oct 2017, In : Neurotoxicity Research. 32, 3, p. 487-495 9 p.

Research output: Contribution to journalArticleResearchpeer-review

The cardiovascular and neurotoxic effects of the venoms of six bony and cartilaginous fish species

Han, H., Baumann, K., Casewell, N. R., Ali, S. A., Dobson, J., Koludarov, I., Debono, J., Cutmore, S. C., Rajapakse, N. W., Jackson, T. N. W., Jones, R., Hodgson, W. C., Fry, B. G. & Kuruppu, S., 16 Feb 2017, In : Toxins. 9, 2, 10 p., 67.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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THE CONCISE GUIDE TO PHARMACOLOGY 2017/18: Overview

Alexander, S. P. H., Kelly, E., Marrion, N. V., Peters, J. A., Faccenda, E., Harding, S. D., Pawson, A. J., Sharman, J. L., Southan, C., Buneman, O. P., Cidlowski, J. A., Christopoulos, A., Davenport, A. P., Fabbro, D., Spedding, M., Striessnig, J., Davies, J. A. & CGTP Collaborators, 1 Dec 2017, In : British Journal of Pharmacology. 174, S1, p. S1-S16 16 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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The effect of tocopheryl phosphates (TPM) on the development of atherosclerosis in apolipoprotein-E deficient mice

Libinaki, R., Vinh, A., Tesanovic-Klajic, S., Widdop, R. & Gaspari, T., 1 Dec 2017, In : Clinical and Experimental Pharmacology and Physiology. 44, S1, p. 107-116 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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The Evolution of Fangs, Venom, and Mimicry Systems in Blenny Fishes

Casewell, N. R., Visser, J. C., Baumann, K., Dobson, J., Han, H., Kuruppu, S., Morgan, M., Romilio, A., Weisbecker, V., Ali, S. A., Debono, J., Koludarov, I., Que, I., Bird, G. C., Cooke, G. M., Nouwens, A. S., Hodgson, W. C., Wagstaff, S. C., Cheney, K. L., Vetter, I. & 3 othersvan der Weerd, L., Richardson, M. K. & Fry, B. G., 24 Apr 2017, In : Current Biology. 27, 8, p. 1184-1191 8 p.

Research output: Contribution to journalArticleResearchpeer-review

The importance and prognostic value of nocturnal blood pressure assessments using inexpensive domestic devices

Head, G. A., 2017, In : Journal of hypertension. 35, 3, p. 463-465 3 p.

Research output: Contribution to journalComment / DebateOtherpeer-review

The opposing roles of NO and oxidative stress in cardiovascular disease

Ritchie, R. H., Drummond, G. R., Sobey, C. G., De Silva, T. M. & Kemp-Harper, B. K., Feb 2017, In : Pharmacological Research. p. 57-69 13 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

Ticks from diverse genera encode chemokine-inhibitory evasin proteins

Hayward, J., Sanchez, J., Perry, A., Huang, C., Rodriguez Valle, M., Canals, M., Payne, R. J. & Stone, M. J., 22 Sep 2017, In : Journal of Biological Chemistry. 292, 38, p. 15670-15680 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Treatment with an interleukin-1 receptor antagonist mitigates neuroinflammation and brain damage after polytrauma

Sun, M., Brady, R. D., Wright, D. K., Kim, H. A., Zhang, S. R., Sobey, C. G., Johnstone, M. R., O'Brien, T. J., Semple, B. D., McDonald, S. J. & Shultz, S. R., Nov 2017, In : Brain, Behavior, and Immunity. 66, p. 359-371 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Vasoactive actions of nitroxyl (HNO) are preserved in resistance arteries in diabetes

Tare, M., Kalidindi, R. S. R., Bubb, K. J., Parkington, H. C., Boon, W-M., Li, X., Sobey, C. G., Drummond, G. R., Ritchie, R. H. & Kemp-Harper, B. K., Apr 2017, In : Naunyn-Schmiedeberg's Archives of Pharmacology. 390, 4, p. 397-408 12 p.

Research output: Contribution to journalArticleResearchpeer-review

What determines the magnitude of cellular response for activation of G protein-coupled receptors?

Furness, S. G. B., Wootten, D. & Sexton, P. M., 6 Feb 2017, In : Cell Cycle. 16, 5, p. 392-394 3 p.

Research output: Contribution to journalEditorialOtherpeer-review

2016

4-phenylpyridin-2-one derivatives: a novel class of positive allosteric modulator of the M1 muscarinic acetylcholine receptor

Mistry, S. N., Jorg, M., Lim, H., Vinh, N. B., Sexton, P. M., Capuano, B., Christopoulos, A., Lane, J. R. & Scammells, P. J., 14 Jan 2016, In : Journal of Medicinal Chemistry. 59, 1, p. 388-409 22 p.

Research output: Contribution to journalArticleResearchpeer-review

Accelerated structure-based design of chemically diverse allosteric modulators of a muscarinic G protein-coupled receptor

Miao, Y., Goldfeld, D. A., Moo, E. V., Sexton, P. M., Christopoulos, A., McCammon, J. A. & Valant, C., 20 Sep 2016, In : Proceedings of the National Academy of Sciences. 113, 38, p. E5675-E5684 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Adverse vascular remodelling is more sensitive than endothelial dysfunction to hyperglycaemia in diabetic rat mesenteric arteries

Kahlberg, N., Qin, C. X., Anthonisz, J., Jap, E., Ng, H. H., Jelinic, M., Parry, L. J., Kemp-Harper, B. K., Ritchie, R. H. & Leo, C. H., 1 Sep 2016, In : Pharmacological Research. 111, p. 325-335 11 p.

Research output: Contribution to journalArticleResearchpeer-review

A hydrogen-bonded polar network in the core of the glucagon-like peptide-1 receptor is a fulcrum for biased agonism: lessons from class B crystal structuress

Wootten, D., Reynolds, C. A., Koole, C., Smith, K. J., Mobarec, J. C., Simms, J., Quon, T., Coudrat, T., Furness, S. G. B., Miller, L. J., Christopoulos, A. & Sexton, P. M., 1 Mar 2016, In : Molecular Pharmacology. 89, 3, p. 335-347 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Airway remodeling and hyperreactivity in a model of bronchopulmonary dysplasia and their modulation by IL-1Ra

Royce, S. G., Nold, M. F., Bui, C. B-Q., Donovan, C., Lam, M., Lamanna, E., Rudloff, I., Bourke, J. E. & Nold-Petry, C. A., 1 Dec 2016, In : American Journal of Respiratory Cell and Molecular Biology. 55, 6, p. 858-868 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Aldosterone-induced oxidative stress and inflammation in the brain are mediated by the endothelial cell mineralocorticoid receptor

Dinh, Q. N., Young, M. J., Evans, M. A., Drummond, G. R., Sobey, C. G. & Chrissobolis, S., 2016, In : Brain Research. 1637, p. 146 - 153 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Allosteric Modulation as a Unifying Mechanism for Receptor Function and Regulation

Changeux, J. P. & Christopoulos, A., 25 Aug 2016, In : Cell. 166, 5, p. 1084-1102 19 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

An allosteric role for receptor activity-modifying proteins in defining GPCR pharmacology

Gingell, J. J., Simms, J., Barwell, J., Poyner, D., Watkins, H. A., Pioszak, A. A., Sexton, P. M. & Hay, D., 17 May 2016, In : Cell Discovery. 2, 14 p., 16012.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Angiotensin AT2-receptor stimulation improves survival and neurological outcome after experimental stroke in mice

Schwengel, K., Namsolleck, P., Lucht, K., Clausen, B. H., Lambertsen, K. L., Valero-Esquitino, V., Thone-Reineke, C., Müller, S., Widdop, R. E., Denton, K. M., Horiuchi, M., Iwai, M., Boato, F., Dahlof, B., Hallberg, A., Unger, T. & Steckelings, U. M., Aug 2016, In : Journal of Molecular Medicine. 94, 8, p. 957-966 10 p.

Research output: Contribution to journalArticleResearchpeer-review

A novel ligand of calcitonin receptor reveals a potential new sensor that modulates programmed cell death

Furness, S. G. B., Hare, D. L., Kourakis, A., Turnley, A. M. & Wookey, P. J., 2016, In : Cell Death Discovery. 2, 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Antagonism of the proinflammatory and pronociceptive actions of canonical and biased agonists of protease-activated receptor-2

Lieu, T., Savage, E., Zhao, P., Edgington-Mitchell, L., Barlow, N., Bron, R., Poole, D. P., McLean, P., Lohman, R. J., Fairlie, D. P. & Bunnett, N. W., 1 Sep 2016, In : British Journal of Pharmacology. 173, 18, p. 2752-2765 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Antifibrotic actions of Serelaxin: New roles for an old player

Samuel, C. S., Summers, R. J. & Hewitson, T. D., Jun 2016, In : Trends in Pharmacological Sciences. 37, 6, p. 485-497 13 p.

Research output: Contribution to journalReview ArticleOtherpeer-review

Apocynin and ebselen reduce influenza A virus-induced lung inflammation in cigarette smoke-exposed mice

Oostwoud, L. C., Gunasinghe, P., Seow, H. J., Ye, J. M., Selemidis, S., Bozinovski, S. & Vlahos, R., 15 Feb 2016, In : Scientific Reports. 6, 16 p., 20983.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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A single-chain derivative of the relaxin hormone is a functionally selective agonist of the G protein-coupled receptor, RXFP1

Hossain, M. A., Kocan, M., Yao, S. T., Royce, S. G., Nair, V. B., Siwek, C., Patil, N. A., Harrison, I. P., Rosengren, K. J., Selemidis, S., Summers, R. J., Wade, J. D., Bathgate, R. A. D. & Samuel, C. S., 2016, In : Chemical Science. 7, 6, p. 3805-3819 15 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Cardiac tissue injury and remodeling is dependent upon mr regulation of activation pathways in cardiac tissue macrophages

Shen, J. Z. L., Morgan, J., Tesch, G. H., Rickard, A., Chrissobolis, S., Drummond, G. R., Fuller, P. J. & Young, M., 1 Aug 2016, In : Endocrinology. 157, 8, p. 3213-3223 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Caveolae: A role in endothelial inflammation and mechanotransduction?

Shihata, W. A., Michell, D. L., Andrews, K. L. & Chin-Dusting, J. P. F., 20 Dec 2016, In : Frontiers in Physiology. 7, 9 p., 628.

Research output: Contribution to journalReview ArticleResearchpeer-review

Open Access
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Cell-specific mineralocorticoid receptors: Future therapeutic targets for stroke?

Dinh, Q. N., Drummond, G. R., Sobey, C. G. & Chrissobolis, S., 1 Aug 2016, In : Neural Regeneration Research. 11, 8, p. 1230-1231 2 p.

Research output: Contribution to journalComment / DebateOtherpeer-review

Central proopiomelanocortin but not neuropeptide Y mediates sympathoexcitation and hypertension in fat fed conscious rabbits

Barzel, B., Lim, K., Davern, P. J., Burke, S. L., Armitage, J. A. & Head, G. A., Mar 2016, In : Journal of hypertension. 34, 3, p. 464-473 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Cerebral small vessel disease: Targeting oxidative stress as a novel therapeutic strategy?

De Silva, T. M. & Miller, A. A., 17 Mar 2016, In : Frontiers in Pharmacology. 7, 18 p., 61.

Research output: Contribution to journalReview ArticleOtherpeer-review

Open Access
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Changes in hypoxia-inducible factor-1 (HIF-1) and regulatory prolyl hydroxylase (PHD) enzymes following hypoxic-ischemic injury in the neonatal rat

Chu, H. X. & Jones, N. M., Mar 2016, In : Neurochemical Research. 41, 3, p. 515-522 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Characteristics of renal sympathetic nerve single units in rabbits with angiotensin-induced hypertension

Burke, S. L., Lukoshkova, E. V. & Head, G. A., 1 Jan 2016, In : Experimental Physiology. 101, 1, p. 50-66 17 p.

Research output: Contribution to journalArticleResearchpeer-review

CIS is a potent checkpoint in NK cell-mediated tumor immunity

Delconte, R. B., Kolesnik, T. B., Dagley, L. F., Rautela, J., Shi, W., Putz, E. M., Stannard, K., Zhang, J. G., Teh, C. E-Y., Firth, M., Ushiki, T., Andoniou, C. E., Degli-Esposti, M. A., Sharp, P. P., Sanvitale, C. E., Infusini, G., Liau, N. P. D., Linossi, E. M., Burns, C. J., Carotta, S. & 12 othersGray, D. H. D., Seillet, C., Hutchinson, D. S., Belz, G. T., Webb, A. I., Alexander, W. S., Li, S. S., Bullock, A. N., Babon, J. J., Smyth, M. J., Nicholson, S. E. & Huntington, N. D., 21 Jun 2016, In : Nature Immunology. 17, 7, p. 816-824 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Clickable Photoaffinity Ligands for Metabotropic Glutamate Receptor 5 Based on Select Acetylenic Negative Allosteric Modulators

Gregory, K., Velagaleti, R., Thal, D. M., Brady, R. M., Christopoulos, A., Conn, P. J. & Lapinsky, D. J., 15 Jul 2016, In : ACS Chemical Biology. 11, 7, p. 1870-1879 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Clinical and pharmacological investigation of Myotoxicity in Sri Lankan Russell’s Viper (Daboia russelii) envenoming

Silva, A., Johnston, C., Kuruppu, S., Kneisz, D., Maduwage, K., Kleifeld, O., Smith, A. I., Siribaddana, S., Buckley, N. A., Hodgson, W. C. & Isbister, G. K., 2 Dec 2016, In : PLoS Neglected Tropical Diseases. 10, 12, 18 p., 0005172.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Combining an epithelial repair factor and anti-fibrotic with a corticosteroid offers optimal treatment for allergic airways disease

Patel, K. P., Giraud, A. S., Samuel, C. S. & Royce, S. G., 2016, In : British Journal of Pharmacology. 173, 12, p. 2016 - 2029 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Comparison of sympathetic nerve activity normalization procedures in conscious rabbits

Burke, S. L., Lim, K., Moretti, J-L. & Head, G. A., 1 May 2016, In : American Journal of Physiology - Heart and Circulatory Physiology. 310, 9, p. H1222-H1232 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Compound 21, a selective agonist of angiotensin AT2 receptors, prevents endothelial inflammation and leukocyte adhesion in vitro and in vivo

Sampson, A. K., Irvine, J. C., Shihata, W. A., Dragoljevic, D., Lumsden, N., Huet, O., Barnes, T., Unger, T., Steckelings, U. M., Jennings, G. L., Widdop, R. E. & Chin-Dusting, J. P. F., 1 Feb 2016, In : British Journal of Pharmacology. 173, 4, p. 729-740 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Contribution of Orexin to the neurogenic hypertension in BPH/2J mice

Jackson, K. L., Dampney, B. W., Moretti, J-L., Stevenson, E. R., Davern, P. J., Carrive, P. & Head, G. A., May 2016, In : Journal of hypertension. 67, 5, p. 959-969 11 p.

Research output: Contribution to journalArticleResearchpeer-review

CORRIGENDUM: N-terminal domain of Bothrops asper Myotoxin II Enhances the Activity of Endothelin Converting Enzyme-1 and Neprilysin

Smith, A. I., Rajapakse, N. W., Kleifeld, O., Lomonte, B., Sikanyika, N. L., Spicer, A. J., Hodgson, W. C., Conroy, P., Small, D. H., Kaye, D. M., Parkington, H. C., Whisstock, J. & Kuruppu, D. M. S., 2016, In : Scientific Reports. 6, Article # 24333, p. 1 - 1 1 p.

Research output: Contribution to journalArticleOther

Could burning fat start with a brite spark? Pharmacological and nutritional ways to promote thermogenesis

Merlin, J., Evans, B. A., Dehvari, N., Sato, M., Bengtsson, T. & Hutchinson, D. S., 2016, In : Molecular Nutrition and Food Research. 60, 1, p. 18-42 25 p.

Research output: Contribution to journalArticleResearchpeer-review

Cross-neutralisation of in vitro neurotoxicity of asian and Australian snake neurotoxins and venoms by different antivenoms

Silva, A., Hodgson, W. C. & Isbister, G. K., 1 Oct 2016, In : Toxins. 8, 10, 18 p., 302.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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