Research Output 1986 2019

2017

Fluorescent diphenylphosphonate-based probes for detection of serine protease activity during inflammation

Edgington-Mitchell, L. E., Barlow, N., Aurelio, L., Samha, A., Szabo, M., Graham, B. & Bunnett, N., 15 Jan 2017, In : Bioorganic and Medicinal Chemistry Letters. 27, 2, p. 254-260 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Garlic-inspired trisulfide linkers for thiol-stimulated H2S release

Ercole, F., Whittaker, M. R., Halls, M. L., Boyd, B. J., Davis, T. P. & Quinn, J. F., 2017, In : Chemical Communications. 53, 57, p. 8030-8033 4 p.

Research output: Contribution to journalArticleResearchpeer-review

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G-CSF receptor blockade ameliorates arthritic pain and disease

Lee, M. C., McCubbin, J. A., Christensen, A. D., Poole, D. P., Rajasekhar, P., Lieu, T., Bunnett, N. W., Garcia-Caraballo, S., Erickson, A., Brierley, S. M., Saleh, R., Achuthan, A., Fleetwood, A. J., Anderson, R. L., Hamilton, J. A. & Cook, A. D., 1 May 2017, In : Journal of Immunology. 198, 9, p. 3565-3575 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Genetically encoded photocross-linkers determine the biological binding site of exendin-4 peptide in the N-terminal domain of the intact human glucagon-like peptide-1 receptor (GLP-1R)

Koole, C., Reynolds, C. A., Mobarec, J. C., Hick, C., Sexton, P. M. & Sakmar, T. P., 28 Apr 2017, In : Journal of Biological Chemistry. 292, 17, p. 7131-7144 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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High throughput, quantitative analysis of human osteoclast differentiation and activity

Diepenhorst, N., Nowell, C., Rueda, P., Henriksen, K., Pierce, T., Cook, A., Pastoureau, P., Sabatini, M., Charman, W., Christopoulos, A., Summers, R., Sexton, P. & Langmead, C., 15 Feb 2017, In : Analytical Biochemistry. 519, p. 51-56 6 p.

Research output: Contribution to journalArticleResearchpeer-review

How the cobra got its flesh-eating venom: Cytotoxicity as a defensive innovation and its co-evolution with hooding, aposematic marking, and spitting

Panagides, N., Jackson, T. N. W., Ikonomopoulou, M. P., Arbuckle, K., Pretzler, R., Yang, D. C., Ali, S. A., Koludarov, I., Dobson, J., Sanker, B., Asselin, A., Santana, R. C., Hendrikx, I., van der Ploeg, H., Tai-A-Pin, J., van den Bergh, R., Kerkkamp, H. M. I., Vonk, F. J., Naude, A., Strydom, M. A. & 6 othersJacobsz, L., Dunstan, N., Jaeger, M., Hodgson, W. C., Miles, J. & Fry, B. G., 13 Mar 2017, In : Toxins. 9, 3, 22 p., 103.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Improving virtual screening of G protein-coupled receptors via ligand-directed modeling

Coudrat, T., Simms, J., Christopoulos, A., Wootten, D. & Sexton, P. M., 1 Nov 2017, In : PLoS Computational Biology. 13, 11, 40 p., e1005819.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Inhibition of the KCa3.1 channel alleviates established pulmonary fibrosisin a large animal model

Organ, L., Bacci, B., Koumoundouros, E., Kimpton, W. G., Samuel, C. S., Nowell, C. J., Bradding, P., Roach, K. M., Westall, G., Jaffar, J. & Snibson, K. J., 1 Apr 2017, In : American Journal of Respiratory Cell and Molecular Biology. 56, 4, p. 539-550 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Isoform-specific biased agonism of histamine H3 receptor agonists

Riddy, D. M., Cook, A. E., Diepenhorst, N. A., Bosnyak, S., Brady, R., La Cour, C. M., Mocaer, E., Summers, R. J., Charman, W. N., Sexton, P. M., Christopoulos, A. & Langmead, C. J., 1 Feb 2017, In : Molecular Pharmacology. 91, 2, p. 87-99 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Key determinants of selective binding and activation by the monocyte chemoattractant proteins at the chemokine receptor CCR2

Huma, Z. E., Sanchez, J., Lim, H. D., Bridgford, J. L., Huang, C., Parker, B. J., Pazhamalil, J. G., Porebski, B. T., Pfleger, K. D. G., Lane, J. R., Canals, M. & Stone, M. J., 23 May 2017, In : Science Signaling. 10, 480, 13 p., eaai8529.

Research output: Contribution to journalArticleResearchpeer-review

Latrophilin receptors: Novel bronchodilator targets in asthma

Faiz, M. A., Donovan, C., Nieuwenhuis, M. A. E., Van Den Berge, M., Postma, D. S., Yao, S., Park, C. Y., Hirsch, R., Fredberg, J. J., Tjin, G., Halayko, A. J., Rempel, K. L., Ward, J. P. T., Lee, T., Bossé, Y., Nickle, D. C., Obeidat, M., Vonk, J. M., Black, J. L., Oliver, B. G. & 4 othersKrishnan, R., McParland, B., Bourke, J. E. & Burgess, J. K., 1 Jan 2017, In : Thorax. 72, 1, p. 74-82 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Lung health in a changing world

Peters, M. J. & Bourke, J. E., 20 Nov 2017, In : Medical Journal of Australia. 207, 10, p. 426-428 3 p.

Research output: Contribution to journalEditorialOtherpeer-review

M1 muscarinic allosteric modulators slow prion neurodegeneration and restore memory loss

Bradley, S. J., Bourgognon, J. M., Sanger, H. E., Verity, N., Mogg, A. J., White, D. J., Butcher, A. J., Moreno, J. A., Molloy, C., Macedo-Hatch, T., Edwards, J. M., Wess, J., Pawlak, R., Read, D. J., Sexton, P. M., Broad, L. M., Steinert, J. R., Mallucci, G. R., Christopoulos, A., Felder, C. C. & 1 othersTobin, A. B., 1 Feb 2017, In : Journal of Clinical Investigation. 127, 2, p. 487-499 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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ML290 is a biased allosteric agonist at the relaxin receptor RXFP1

Kocan, M., Sarwar, M., Ang, S. Y., Xiao, J., Marugan, J., Hossain, M. A., Wang, C., Hutchinson, D. S., Samuel, C. S., Agoulnik, A. I., Bathgate, R. A. D. & Summers, R. J., 1 Dec 2017, In : Scientific Reports. 7, 1, 14 p., 2968.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Molecular insights into allosteric modulation of Class C G protein-coupled receptors

Leach, K. & Gregory, K. J., 1 Feb 2017, In : Pharmacological Research. 116, p. 105-118 14 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

Neurokinin 1 receptor signaling in endosomes mediates sustained nociception and is a viable therapeutic target for prolonged pain relief

Jensen, D. D., Lieu, T., Halls, M. L., Veldhuis, N. A., Imlach, W. L., Mai, Q. N., Poole, D. P., Quach, T., Aurelio, L., Conner, J., Klein Herenbrink, C., Barlow, N., Simpson, J. S., Scanlon, M. J., Graham, B., McCluskey, A., Robinson, P. J., Escriou, V., Nassini, R., Materazzi, S. & 6 othersGeppetti, P., Hicks, G. A., Christie, M. J., Porter, C. J. H., Canals, M. & Bunnett, N. W., 31 May 2017, In : Science Translational Medicine. 9, 392, 15 p., aal3447.

Research output: Contribution to journalArticleResearchpeer-review

Neurotoxicity in Sri Lankan Russell’s Viper (Daboia russelii) Envenoming is Primarily due to U1-viperitoxin-Dr1a, a Pre-Synaptic Neurotoxin

Silva, A., Kuruppu, S., Othman, I., Goode, R. J. A., Hodgson, W. C. & Isbister, G. K., Jan 2017, In : Neurotoxicity Research. 31, 1, p. 11-19 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Neutrophil-derived S100 calcium-binding proteins A8/A9 promote reticulated thrombocytosis and atherogenesis in diabetes

Kraakman, M. J., Lee, M. K. S., Al-Sharea, A., Dragoljevic, D., Barrett, T. J., Montenont, E., Basu, D., Heywood, S. E., Kammoun, H. L., Flynn, M., Whillas, A., Hanssen, N. M. J., Febbraio, M. A., Westein, E., Fisher, E. A., Chin-Dusting, J., Cooper, M. E., Berger, J. S., Goldberg, I. J., Nagareddy, P. R. & 1 othersMurphy, A. J., 1 Jun 2017, In : Journal of Clinical Investigation. 127, 6, p. 2133-2147 15 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Nicotinic acetylcholine receptor alpha 7 stimulation dampens splenic myelopoiesis and inhibits atherogenesis in Apoe−/− mice

Al-Sharea, A., Lee, M. K. S., Whillas, A., Flynn, M. C., Chin-Dusting, J. & Murphy, A. J., 1 Oct 2017, In : Atherosclerosis. 265, p. 47-53 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Novel approaches for treating hypertension

Freeman, A. J., Vinh, A. & Widdop, R. E., 27 Jan 2017, In : F1000Research. 6, 7 p., 80.

Research output: Contribution to journalReview ArticleResearchpeer-review

Open Access
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PB1-F2 peptide derived from avian influenza A virus H7N9 induces inflammation via activation of the NLRP3 inflammasome

Pinar, A., Dowling, J. K., Bitto, N. J., Robertson, A. A. B., Latz, E., Stewart, C. R., Drummond, G. R., Cooper, M. A., McAuley, J. L., Tate, M. D. & Mansell, A., 20 Jan 2017, In : Journal of Biological Chemistry. 292, 3, p. 826-836 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Phase-plate cryo-EM structure of a class B GPCR-G-protein complex

Liang, Y-L., Khoshouei, M., Radjainia, M., Zhang, Y., Glukhova, A., Tarrasch, J., Thal, D., Furness, S. G. B., Christopoulos, G., Coudrat, T., Danev, R., Baumeister, W., Miller, L. J., Christopoulos, A., Kobilka, B., Wootten, D., Skiniotis, G. & Sexton, P., 1 Jun 2017, In : Nature. 546, 7656, p. 118-123 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Positive allosteric modulation of GABAA receptors attenuates high blood pressure in Schlager hypertensive mice

Stevenson, E. R., Johns, E. M. C., Marques, F. Z., Jackson, K. L., Davern, P. J., Evans, R. G. & Head, G. A., Mar 2017, In : Journal of Hypertension. 35, 3, p. 546-557 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Potent neuroprotection after stroke afforded by a double-knot spider-venom peptide that inhibits acid-sensing ion channel 1a

Chassagnon, I. R., McCarthy, C. A., Chin, Y. K. Y., Pineda, S. S., Keramidas, A., Mobli, M., Pham, V., De Silva, T. M., Lynch, J. W., Widdop, R. E., Rash, L. D. & King, G. F., 4 Apr 2017, In : Proceedings of the National Academy of Sciences. 114, 14, p. 3750-3755 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Precise control of drug loading and release of an NSAID-polymer conjugate for long term osteoarthritis intra-articular drug delivery

Sulistio, A., Reyes-Ortega, F., D'Souza, A. M., Ng, S. M. Y., Valade, D., Quinn, J. F., Donohue, A. C., Mansfeld, F., Blencowe, A., Qiao, G., Prankerd, R., Quirk, S., Whittaker, M. R., Davis, T. P. & Tait, R. J., 1 Jan 2017, In : Journal of Materials Chemistry B. 5, 31, p. 6221-6226 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Pressor response to angiotensin II is enhanced in aged mice and associated with inflammation, vasoconstriction and oxidative stress

Dinh, Q. N., Drummond, G. R., Kemp-Harper, B. K., Diep, H., De Silva, T. M., Kim, H. A., Vinh, A., Robertson, A. A. B., Cooper, M. A., Mansell, A., Chrissobolis, S. & Sobey, C. G., 28 Jun 2017, In : Aging. 9, 6, p. 1595-1605 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Recent progress in the understanding of relaxin family peptides and their receptors

Summers, R. J., 2017, In : British Journal of Pharmacology. 174, 10, p. 915-920 6 p.

Research output: Contribution to journalEditorialOtherpeer-review

Open Access
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Relaxin contributes to the regulation of arterial pressure in adult female mice

Colafella, K. M. M., Samuel, C. S. & Denton, K. M., 28 Nov 2017, In : Clinical Science. 131, 23, p. 2795-2805 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Signal transduction pathways activated by insulin-like peptide 5 at the relaxin family peptide RXFP4 receptor

Ang, S. Y., Hutchinson, D. S., Patil, N., Evans, B. A., Bathgate, R. A. D., Halls, M. L., Hossain, M. A., Summers, R. J. & Kocan, M., 1 May 2017, In : British Journal of Pharmacology. 174, 10, p. 1077-1089 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Small-molecule-biased formyl peptide receptor agonist compound 17b protects against myocardial ischaemia-reperfusion injury in mice

Qin, C. X., May, L. T., Li, R., Cao, N., Rosli, S., Deo, M., Alexander, A. E., Horlock, D., Bourke, J. E., Yang, Y. H., Stewart, A. G., Kaye, D. M., Du, X. J., Sexton, P. M., Christopoulos, A., Gao, X. M. & Ritchie, R. H., 7 Feb 2017, In : Nature Communications. 8, 13 p., 14232.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Structural features embedded in G protein-coupled receptor co-crystal structures are key to their success in virtual screening

Coudrat, T., Christopoulos, A., Sexton, P. M. & Wootten, D., 1 Apr 2017, In : PLoS ONE. 12, 4, 29 p., e0174719.

Research output: Contribution to journalArticleResearchpeer-review

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Structure of the adenosine A1 receptor reveals the basis for subtype selectivity

Glukhova, A., Thal, D. M., Nguyen, A. T., Vecchio, L., Jorg, M., Scammells, P. J., May, L. T., Sexton, P. M. & Christopoulos, A., 23 Feb 2017, In : Cell. 168, 5, p. 867-877.e13

Research output: Contribution to journalArticleResearchpeer-review

Targeting adenosine receptors for the treatment of cardiac fibrosis

Vecchio, E. A., White, P. J. & May, L. T., 5 May 2017, In : Frontiers in Pharmacology. 8, MAY, 7 p., 243.

Research output: Contribution to journalReview ArticleOtherpeer-review

Open Access
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The actions of relaxin family peptides on signal transduction pathways activated by the relaxin family peptide receptor RXFP4

Ang, S. Y., Hutchinson, D. S., Evans, B. A., Hossain, M. A., Patil, N., Bathgate, R. A. D., Kocan, M. & Summers, R. J., Jan 2017, In : Naunyn-Schmiedeberg's Archives of Pharmacology. 390, 1, p. 105-111 7 p.

Research output: Contribution to journalArticleResearchpeer-review

The actions of relaxin on the human cardiovascular system

Sarwar, M., Du, X. J., Dschietzig, T. B. & Summers, R. J., 1 May 2017, In : British Journal of Pharmacology. 174, 10, p. 933-949 17 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

The Bold and the Beautiful: a Neurotoxicity Comparison of New World Coral Snakes in the Micruroides and Micrurus Genera and Relative Neutralization by Antivenom

Yang, D. C., Dobson, J., Cochran, C., Dashevsky, D., Arbuckle, K., Benard, M., Boyer, L., Alagón, A., Hendrikx, I., Hodgson, W. C. & Fry, B. G., Oct 2017, In : Neurotoxicity Research. 32, 3, p. 487-495 9 p.

Research output: Contribution to journalArticleResearchpeer-review

The cardiovascular and neurotoxic effects of the venoms of six bony and cartilaginous fish species

Han, H., Baumann, K., Casewell, N. R., Ali, S. A., Dobson, J., Koludarov, I., Debono, J., Cutmore, S. C., Rajapakse, N. W., Jackson, T. N. W., Jones, R., Hodgson, W. C., Fry, B. G. & Kuruppu, S., 16 Feb 2017, In : Toxins. 9, 2, 10 p., 67.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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THE CONCISE GUIDE TO PHARMACOLOGY 2017/18: Overview

Alexander, S. P. H., Kelly, E., Marrion, N. V., Peters, J. A., Faccenda, E., Harding, S. D., Pawson, A. J., Sharman, J. L., Southan, C., Buneman, O. P., Cidlowski, J. A., Christopoulos, A., Davenport, A. P., Fabbro, D., Spedding, M., Striessnig, J., Davies, J. A. & CGTP Collaborators, 1 Dec 2017, In : British Journal of Pharmacology. 174, S1, p. S1-S16 16 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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The effect of tocopheryl phosphates (TPM) on the development of atherosclerosis in apolipoprotein-E deficient mice

Libinaki, R., Vinh, A., Tesanovic-Klajic, S., Widdop, R. & Gaspari, T., 1 Dec 2017, In : Clinical and Experimental Pharmacology and Physiology. 44, S1, p. 107-116 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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The Evolution of Fangs, Venom, and Mimicry Systems in Blenny Fishes

Casewell, N. R., Visser, J. C., Baumann, K., Dobson, J., Han, H., Kuruppu, S., Morgan, M., Romilio, A., Weisbecker, V., Ali, S. A., Debono, J., Koludarov, I., Que, I., Bird, G. C., Cooke, G. M., Nouwens, A. S., Hodgson, W. C., Wagstaff, S. C., Cheney, K. L., Vetter, I. & 3 othersvan der Weerd, L., Richardson, M. K. & Fry, B. G., 24 Apr 2017, In : Current Biology. 27, 8, p. 1184-1191 8 p.

Research output: Contribution to journalArticleResearchpeer-review

The importance and prognostic value of nocturnal blood pressure assessments using inexpensive domestic devices

Head, G. A., 2017, In : Journal of Hypertension. 35, 3, p. 463-465 3 p.

Research output: Contribution to journalComment / DebateOtherpeer-review

The opposing roles of NO and oxidative stress in cardiovascular disease

Ritchie, R. H., Drummond, G. R., Sobey, C. G., De Silva, T. M. & Kemp-Harper, B. K., Feb 2017, In : Pharmacological Research. p. 57-69 13 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

Ticks from diverse genera encode chemokine-inhibitory evasin proteins

Hayward, J., Sanchez, J., Perry, A., Huang, C., Rodriguez Valle, M., Canals, M., Payne, R. J. & Stone, M. J., 22 Sep 2017, In : Journal of Biological Chemistry. 292, 38, p. 15670-15680 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Treatment with an interleukin-1 receptor antagonist mitigates neuroinflammation and brain damage after polytrauma

Sun, M., Brady, R. D., Wright, D. K., Kim, H. A., Zhang, S. R., Sobey, C. G., Johnstone, M. R., O'Brien, T. J., Semple, B. D., McDonald, S. J. & Shultz, S. R., Nov 2017, In : Brain, Behavior, and Immunity. 66, p. 359-371 13 p.

Research output: Contribution to journalArticleResearchpeer-review