Research Output 1986 2020

2018
22 Citations (Scopus)

Protease-activated receptor-2 in endosomes signals persistent pain of irritable bowel syndrome

Jimenez-Vargas, N. N., Pattison, L. A., Zhao, P., Lieu, T., Latorre, R., Jensen, D. D., Castro, J., Aurelio, L., Le, G. T., Flynn, B., Herenbrink, C. K., Yeatman, H. R., Edgington-Mitchell, L., Porter, C. J. H., Halls, M. L., Canals, M., Veldhuis, N. A., Poole, D. P., McLean, P., Hicks, G. A. & 7 others, Scheff, N., Chen, E., Bhattacharya, A., Schmidt, B. L., Brierley, S. M., Vanner, S. J. & Bunnett, N. W., 31 Jul 2018, In : Proceedings of the National Academy of Sciences of the United States of America. 115, 31, p. E7438-E7447 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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3 Citations (Scopus)

Proteomic Characterization of Two Medically Important Malaysian Snake Venoms, Calloselasma rhodostoma (Malayan Pit Viper) and Ophiophagus hannah (King Cobra)

Kunalan, S., Othman, I., Syed Hassan, S. & Hodgson, W. C., 26 Oct 2018, In : Toxins. 10, 11, 36 p., 434.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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2 Citations (Scopus)

Proteomic Identification of Interferon-Induced Proteins with Tetratricopeptide Repeats as Markers of M1 Macrophage Polarization

Huang, C., Lewis, C., Borg, N. A., Canals, M., Diep, H., Drummond, G. R., Goode, R. J., Schittenhelm, R. B., Vinh, A., Zhu, M., Kemp-Harper, B., Kleifeld, O. & Stone, M. J., 6 Apr 2018, In : Journal of Proteome Research. 17, 4, p. 1485-1499 15 p.

Research output: Contribution to journalArticleResearchpeer-review

11 Citations (Scopus)

Rattling the border wall: Pathophysiological implications of functional and proteomic venom variation between Mexican and US subspecies of the desert rattlesnake Crotalus scutulatus

Dobson, J., Yang, D. C., op den Brouw, B., Cochran, C., Huynh, T., Kurrupu, S., Sánchez, E. E., Massey, D. J., Baumann, K., Jackson, T. N. W., Nouwens, A., Josh, P., Neri-Castro, E., Alagón, A., Hodgson, W. C. & Fry, B. G., 1 Feb 2018, In : Comparative Biochemistry and Physiology Part - C: Toxicology and Pharmacology. 205, p. 62-69 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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15 Citations (Scopus)

Recent advances in the determination of G protein-coupled receptor structures

Thal, D. M., Vuckovic, Z., Draper-Joyce, C. J., Liang, Y-L., Glukhova, A., Christopoulos, A. & Sexton, P. M., 1 Aug 2018, In : Current Opinion in Structural Biology. 51, p. 28-34 7 p.

Research output: Contribution to journalArticleResearchpeer-review

5 Citations (Scopus)

Regulation of the human placental (pro)renin receptor-prorenin-angiotensin system by microRNAs

Wang, Y., Lumbers, E. R., Arthurs, A. L., Corbisier de Meaultsart, C., Mathe, A., Avery-Kiejda, K. A., Roberts, C. T., Broughton Pipkin, F., Marques, F. Z., Morris, B. J. & Pringle, K. G., 1 Sep 2018, In : Molecular Human Reproduction. 24, 9, p. 453-464 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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2 Citations (Scopus)

Renal nerves contribute to hypertension in Schlager BPH/2J mice

Gueguen, C., Jackson, K. L., Marques, F. Z., Eikelis, N., Phillips, S., Stevenson, E. R., Charchar, F. J., Lambert, G. W., Davern, P. J. & Head, G. A., 10 Dec 2018, In : Hypertension Research. 42, p. 306-318 13 p.

Research output: Contribution to journalArticleResearchpeer-review

1 Citation (Scopus)

Reply to ‘Antipsychotics with similar association kinetics at dopamine D2 receptors differ in extrapyramidal side-effects’

Sykes, D. A., Lane, J. R., Szabo, M., Capuano, B., Javitch, J. A. & Charlton, S. J., 1 Dec 2018, In : Nature Communications. 9, 1, 5 p., 3568.

Research output: Contribution to journalLetterResearchpeer-review

Open Access
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6 Citations (Scopus)

Rosiglitazone and a β3-adrenoceptor agonist are both required for functional browning of white adipocytes in culture

Merlin, J., Sato, M., Chia, L. Y., Fahey, R., Pakzad, M., Nowell, C. J., Summers, R. J., Bengtsson, T., Evans, B. A. & Hutchinson, D. S., 30 May 2018, In : Frontiers in Endocrinology. 9, MAY, 17 p., 249.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Rules of Engagement: GPCRs and G Proteins

Glukhova, A., Draper-Joyce, C. J., Sunahara, R. K., Christopoulos, A., Wootten, D. L. & Sexton, P. M., 7 Sep 2018, In : ACS Pharmacology and Translational Sciences. 1, 2, p. 73-83 11 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

4 Citations (Scopus)

Serelaxin as a novel therapeutic opposing fibrosis and contraction in lung diseases

Lam, M., Royce, S. G., Samuel, C. S. & Bourke, J. E., Jul 2018, In : Pharmacology and Therapeutics. 187, p. 61-70 10 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

58 Citations (Scopus)

Structural insights into G-protein-coupled receptor allostery

Thal, D. M., Glukhova, A., Sexton, P. M. & Christopoulos, A., 5 Jul 2018, In : Nature. 559, 7712, p. 45-53 9 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

2 Citations (Scopus)

Structure-Activity Relationships of Pan-Gαq/11 Coupled Muscarinic Acetylcholine Receptor Positive Allosteric Modulators

Berizzi, A. E., Bender, A. M., Lindsley, C. W., Conn, P. J., Sexton, P. M., Langmead, C. J. & Christopoulos, A., 18 Jul 2018, In : ACS Chemical Neuroscience. 9, 7, p. 1818-1828 11 p.

Research output: Contribution to journalArticleResearchpeer-review

15 Citations (Scopus)

Structure-based discovery of selective positive allosteric modulators of antagonists for the M2 muscarinic acetylcholine receptor

Korczynska, M., Clark, M. J., Valant, C., Xu, J., Moo, E. V., Albold, S., Weiss, D. R., Torosyan, H., Huang, W., Kruse, A. C., Lyda, B. R., May, L. T., Baltos, J. A., Sexton, P. M., Kobilka, B. K., Christopoulos, A., Shoichet, B. K. & Sunahara, R. K., 6 Mar 2018, In : Proceedings of the National Academy of Sciences. 115, 10, p. E2419-E2428 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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69 Citations (Scopus)

Structure of the adenosine-bound human adenosine A1 receptor-Gi complex

Draper-Joyce, C. J., Khoshouei, M., Thal, D. M., Liang, Y. L., Nguyen, A. T. N., Furness, S. G. B., Venugopal, H., Baltos, J. A., Plitzko, J. M., Danev, R., Baumeister, W., May, L. T., Wootten, D., Sexton, P. M., Glukhova, A. & Christopoulos, A., 20 Jun 2018, In : Nature. 558, 7711, p. 559-565 7 p.

Research output: Contribution to journalArticleResearchpeer-review

5 Citations (Scopus)

The action of a negative allosteric modulator at the dopamine D2 receptor is dependent upon sodium ions

Draper-Joyce, C. J., Verma, R. K., Michino, M., Shonberg, J., Kopinathan, A., Klein Herenbrink, C., Scammells, P. J., Capuano, B., Abramyan, A. M., Thal, D. M., Javitch, J. A., Christopoulos, A., Shi, L. & Lane, J. R., 1 Dec 2018, In : Scientific Reports. 8, 1, 12 p., 1208.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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7 Citations (Scopus)

The structural determinants of the bitopic binding mode of a negative allosteric modulator of the dopamine D2 receptor

Draper-Joyce, C. J., Michino, M., Verma, R. K., Klein Herenbrink, C., Shonberg, J., Kopinathan, A., Scammells, P. J., Capuano, B., Thal, D. M., Javitch, J. A., Christopoulos, A., Shi, L. & Lane, J. R., 1 Feb 2018, In : Biochemical Pharmacology. 148, p. 315-328 14 p.

Research output: Contribution to journalArticleResearchpeer-review

2 Citations (Scopus)
Open Access
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7 Citations (Scopus)

Toward an understanding of the structural basis of allostery in muscarinic acetylcholine receptors

Burger, W. A. C., Sexton, P. M., Christopoulos, A. & Thal, D. M., 1 Oct 2018, In : Journal of General Physiology. 150, 10, p. 1360-1372 13 p.

Research output: Contribution to journalArticleResearchpeer-review

5 Citations (Scopus)

Two distinct domains of the glucagon-like peptide-1 receptor control peptide-mediated biased agonism

Lei, S., Clydesdale, L., Dai, A., Cai, X., Yang, F., Yang, D., Liang, Y-L., Koole, C., Zhao, P., Coudrat, T., Christopoulos, A., Wang, M-W., Wootten, D. & Sexton, P. M., 1 Jan 2018, In : Journal of Biological Chemistry. 293, 24, p. 9370-9387 18 p.

Research output: Contribution to journalArticleResearchpeer-review

4 Citations (Scopus)

Vascular and molecular pharmacology of the metabolically stable CGRP analogue, SAX

Sheykhzade, M., Abdolalizadeh, B., Koole, C., Pickering, D. S., Dreisig, K., Johansson, S. E., Abboud, B. K., Dreier, R., Berg, J. O., Jeppesen, J. L., Sexton, P. M., Edvinsson, L., Wootten, D. & Sams, A., 15 Jun 2018, In : European Journal of Pharmacology. 829, p. 85-92 8 p.

Research output: Contribution to journalArticleResearchpeer-review

8 Citations (Scopus)

Vitamin D3 Supplementation Reduces Subsequent Brain Injury and Inflammation Associated with Ischemic Stroke

Evans, M. A., Kim, H. A., Ling, Y. H., Uong, S., Vinh, A., De Silva, T. M., Arumugam, T. V., Clarkson, A. N., Zosky, G. R., Drummond, G. R., Broughton, B. R. S. & Sobey, C. G., 1 Mar 2018, In : NeuroMolecular Medicine. 20, 1, p. 147-159 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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6 Citations (Scopus)

“Selective” class C G protein-coupled receptor modulators are neutral or biased mGlu5 allosteric ligands

Hellyer, S. D., Albold, S., Wang, T., Chen, A. N. Y., May, L. T., Leach, K. & Gregory, K. J., 1 May 2018, In : Molecular Pharmacology. 93, 5, p. 504-514 11 p.

Research output: Contribution to journalArticleResearchpeer-review

2017

Acute effect of central administration of urotensin II on baroreflex and blood pressure in conscious normotensive rabbits

Lim, K., Sata, Y., Jackson, K. L., Burke, S. L. & Head, G. A., 23 Feb 2017, In : Frontiers in Physiology. 8, FEB, 9 p., 110.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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19 Citations (Scopus)

Adenylyl cyclase signalling complexes - pharmacological challenges and opportunities

Halls, M. L. & Cooper, D. M. F., Apr 2017, In : Pharmacology and Therapeutics. 172, p. 171-180 10 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

File
8 Citations (Scopus)

Adrenoceptors promote glucose uptake into adipocytes and muscle by an insulin-independent signaling pathway involving mechanistic target of rapamycin complex 2

Mukaida, S., Evans, B. A., Bengtsson, T., Hutchinson, D. S. & Sato, M., 1 Feb 2017, In : Pharmacological Research. 116, p. 87-92 6 p.

Research output: Contribution to journalArticleResearchpeer-review

9 Citations (Scopus)

Advanced atherosclerosis is associated with inflammation, vascular dysfunction and oxidative stress, but not hypertension

Dinh, Q. N., Chrissobolis, S., Diep, H., Chan, C. T., Ferens, D., Drummond, G. R. & Sobey, C. G., Feb 2017, In : Pharmacological Research. p. 70-76 7 p.

Research output: Contribution to journalArticleResearchpeer-review

17 Citations (Scopus)

Airway remodelling and inflammation in asthma are dependent on the extracellular matrix protein fibulin-1c

Liu, G., Cooley, M. A., Nair, P. M., Donovan, C., Hsu, A. C., Jarnicki, A. G., Haw, T. J., Hansbro, N. G., Ge, Q., Brown, A. C., Tay, H., Foster, P. S., Wark, P. A., Horvat, J. C., Bourke, J. E., Grainge, C. L., Argraves, W. S., Oliver, B. G., Knight, D. A., Burgess, J. K. & 1 others, Hansbro, P. M., 1 Dec 2017, In : Journal of Pathology. 243, 4, p. 510-523 14 p.

Research output: Contribution to journalArticleResearchpeer-review

48 Citations (Scopus)

A kinetic view of GPCR allostery and biased agonism

Lane, J. R., May, L. T., Parton, R. G., Sexton, P. M. & Christopoulos, A., 18 Aug 2017, In : Nature Chemical Biology. 13, 9, p. 929-937 9 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

Open Access
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12 Citations (Scopus)

Allosteric modulation as a unifying mechanism for receptor function and regulation

Changeux, J-P. & Christopoulos, A., 1 Sep 2017, In : Diabetes, Obesity and Metabolism. 19, p. 4-21 18 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

Open Access
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34 Citations (Scopus)

Allostery and Biased Agonism at Class B G Protein-Coupled Receptors

Wootten, D., Miller, L. J., Koole, C., Christopoulos, A. & Sexton, P. M., 11 Jan 2017, In : Chemical Reviews. 117, 1, p. 111-138 28 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

6 Citations (Scopus)

Amyloidogenicity at a Distance: How Distal Protein Regions Modulate Aggregation in Disease

Lucato, C. M., Lupton, C. J., Halls, M. L. & Ellisdon, A. M., 5 May 2017, In : Journal of Molecular Biology. 429, 9, p. 1289-1304 16 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

File
7 Citations (Scopus)

Anakinra reduces blood pressure and renal fibrosis in one kidney/DOCA/salt-induced hypertension

Ling, Y. H., Krishnan, S. M., Chan, C. T., Diep, H., Ferens, D., Chin-Dusting, J., Kemp-Harper, B. K., Samuel, C. S., Hewitson, T. D., Latz, E., Mansell, A., Sobey, C. G. & Drummond, G. R., Feb 2017, In : Pharmacological Research. 116, p. 77-86 10 p.

Research output: Contribution to journalArticleResearchpeer-review

34 Citations (Scopus)

Anti-fibrotic actions of relaxin

Samuel, C. S., Royce, S. G., Hewitson, T. D., Denton, K. M., Cooney, T. E. & Bennett, R. G., 1 May 2017, In : British Journal of Pharmacology. 174, 10, p. 962-976 15 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

16 Citations (Scopus)

Anti-fibrotic potential of AT2 receptor agonists

Wang, Y., Del Borgo, M., Lee, H. W., Baraldi, D., Hirmiz, B., Gaspari, T. A., Denton, K. M., Aguilar, M-I., Samuel, C. S. & Widdop, R. E., 31 Aug 2017, In : Frontiers in Pharmacology. 8, 7 p., 564.

Research output: Contribution to journalReview ArticleResearchpeer-review

Open Access
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8 Citations (Scopus)

Antivenom for neuromuscular paralysis resulting from snake envenoming

Silva, A., Hodgson, W. C. & Isbister, G. K., 19 Apr 2017, In : Toxins. 9, 4, 17 p., 143.

Research output: Contribution to journalReview ArticleResearchpeer-review

Open Access
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Antivenom for snake venom-induced neuromuscular paralysis

Silva, A., Maduwage, K., Buckley, N. A., Lalloo, D. G., de Silva, H. J. & Isbister, G. K., 21 Mar 2017, In : Cochrane Database of Systematic Reviews. 2017, 3, 12 p., CD012604.

Research output: Contribution to journalArticleResearchpeer-review

5 Citations (Scopus)

A pharmacological examination of the cardiovascular effects of Malayan krait (Bungarus candidus) venoms

Chaisakul, J., Ahmad Rusmili, M. R., Hodgson, W. C., Hatthachote, P., Suwan, K., Inchan, A., Chanhome, L., Othman, I. & Chootip, K., 29 Mar 2017, In : Toxins. 9, 4, 11 p., 122.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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6 Citations (Scopus)

Apolipoprotein A-I Mimetic Peptides: Discordance between in Vitro and in Vivo Properties - Brief Report

Ditiatkovski, M., Palsson, J., Chin-Dusting, J., Remaley, A. T. & Sviridov, D., 1 Jul 2017, In : Arteriosclerosis, Thrombosis and Vascular Biology. 37, 7, p. 1301-1306 6 p.

Research output: Contribution to journalArticleResearchpeer-review

16 Citations (Scopus)

A polymorphism in the norepinephrine transporter gene is associated with affective and cardiovascular disease through a microRNA mechanism

Marques, FZ., Eikelis, N., Bayles, R. G., Lambert, EA., Straznicky, N. E., Hering, D., Esler, MD., Head, GA., Barton, DA., Schlaich, MP. & Lambert, GW., 1 Jan 2017, In : Molecular Psychiatry. 22, 1, p. 134-141 8 p.

Research output: Contribution to journalArticleResearchpeer-review

1 Citation (Scopus)

A portrait of the sialyl glycan receptor specificity of the H10 influenza virus hemagglutinin—a picture of an avian virus on the verge of becoming a pandemic?

Schneider, E. K., Li, J. & Velkov, T., 13 Dec 2017, In : Vaccines. 5, 4, 15 p., 51.

Research output: Contribution to journalReview ArticleResearchpeer-review

8 Citations (Scopus)

Assessing the anthelmintic activity of pyrazole-5-carboxamide derivatives against Haemonchus contortus

Jiao, Y., Preston, S., Song, H., Jabbar, A., Liu, Y., Baell, J., Hofmann, A., Hutchinson, D., Wang, T., Koehler, A. V., Fisher, G. M., Andrews, K. T., Laleu, B., Palmer, M. J., Burrows, J. N., Wells, T. N. C., Wang, Q. & Gasser, R. B., 31 May 2017, In : Parasites and Vectors. 10, 1, 272.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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18 Citations (Scopus)

Biased allosteric agonism and modulation of metabotropic glutamate receptor 5: implications for optimizing preclinical neuroscience drug discovery

Sengmany, K., Singh, J., Stewart, G. D., Conn, P. J., Christopoulos, A. & Gregory, K. J., 15 Mar 2017, In : Neuropharmacology. 115, p. 60-72 13 p.

Research output: Contribution to journalArticleResearchpeer-review

16 Citations (Scopus)

Capadenoson, a clinically trialed partial adenosine A1 receptor agonist, can stimulate adenosine A2B receptor biased agonism

Baltos, J-A., Vecchio, E. A., Harris, M. A., Qin, C. X., Ritchie, R. H., Christopoulos, A., White, P. J. & May, L. T., 1 Jul 2017, In : Biochemical Pharmacology. 135, p. 79–89 11 p.

Research output: Contribution to journalArticleResearchpeer-review

13 Citations (Scopus)

Characterization of signal bias at the GLP-1 receptor induced by backbone modification of GLP-1

Hager, M. V., Clydesdale, L., Gellman, S. H., Sexton, P. M. & Wootten, D., 15 Jul 2017, In : Biochemical Pharmacology. 136, p. 99-108 10 p.

Research output: Contribution to journalArticleResearchpeer-review

1 Citation (Scopus)

Coding GPCR-G protein specificity

Furness, S. G. B. & Sexton, P. M., 1 Oct 2017, In : Cell Research. 27, 10, p. 1193-1194 2 p.

Research output: Contribution to journalShort SurveyResearchpeer-review

Open Access
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3 Citations (Scopus)

Co-expressed class B G protein-coupled secretin and GLP-1 receptors self- and cross-associate: impact on pancreatic islets

Harikumar, K. G., Lau, S., Sexton, P. M., Wootten, D. & Miller, L. J., 1 Jun 2017, In : Endocrinology. 158, 6, p. 1685-1700 16 p.

Research output: Contribution to journalArticleResearchpeer-review

5 Citations (Scopus)

Dianthin-30 or gelonin versus monomethyl auristatin E, each configured with an anti-calcitonin receptor antibody, are differentially potent in vitro in high-grade glioma cell lines derived from glioblastoma

Gilabert-Oriol, R., Furness, S. G. B., Stringer, B. W., Weng, A., Fuchs, H., Day, B. W., Kourakis, A., Boyd, A. W., Hare, D. L., Thakur, M., Johns, T. G. & Wookey, P. J., 2017, In : Cancer Immunology Immunotherapy. 66, 9, p. 1217–1228 12 p.

Research output: Contribution to journalArticleResearchpeer-review