Research Output 1986 2020

2013
5 Citations (Scopus)

Structural biology: meet the B family

Sexton, P. & Wootten, D. L., 2013, In : Nature. 499, 7459, p. 417 - 418 2 p.

Research output: Contribution to journalLetterOther

20 Citations (Scopus)

Supra-physiological efficacy at GPCRs: superstition or super agonists?

Langmead, C. J. & Christopoulos, A., 2013, In : British Journal of Pharmacology. 169, 2, p. 353 - 356 4 p.

Research output: Contribution to journalArticleOtherpeer-review

13 Citations (Scopus)

The anti-fibrotic hormone relaxin is not reno-protective, despite being active, in an experimental model of type 1 diabetes

Wong, S. E., Samuel, C. S., Kelly, D. J., Zhang, Y., Becker, G. & Hewitson, T. D., 2013, In : Protein and Peptide Letters. 20, 9, p. 1029 - 1038 10 p.

Research output: Contribution to journalArticleResearchpeer-review

66 Citations (Scopus)

The apelin receptor inhibits the angiotensin II type 1 receptor via allosteric trans-inhibition

Siddiquee, K., Hampton, J., McAnally, D., May, L. T. & Smith, L. H., 2013, In : British Journal of Pharmacology. 168, 5, p. 1104 - 1117 14 p.

Research output: Contribution to journalArticleResearchpeer-review

15 Citations (Scopus)

The nitric oxide redox sibling nitroxyl partially circumvents impairment of platelet nitric oxide responsiveness

Dautov, R., Ngo, D., Licari, G., Liu, S., Sverdlov, A. L., Ritchie, R. H., Harper, B. K., Horowitz, J. D. & Chirkov, Y. Y., 2013, In : Nitric Oxide-Biology and Chemistry. 35, p. 72 - 78 7 p.

Research output: Contribution to journalArticleResearchpeer-review

18 Citations (Scopus)

The role of ghrelin in neuroprotection after ischemic brain injury

Spencer, S. J., Miller, A. A. & Andrews, Z. B., 1 Jan 2013, In : Brain Sciences. 3, 1, p. 344-359 16 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

Tiger snake (Notechis spp) envenoming: Australian Snakebite Project (ASP-13).

Isbister, G. K., Buckley, N. A. & Brown, S. G., 4 Mar 2013, In : Medical Journal of Australia. 198, 4, p. 194-195 2 p.

Research output: Contribution to journalComment / DebateOtherpeer-review

16 Citations (Scopus)

Trefoil factor-2 reverses airway remodeling changes in allergic airways disease

Royce, S. G., Lim, C., Muljadi, R. C. M., Samuel, C. S., Ververis, K., Karagiannis, T. C., Giraud, A. S. & Tang, M. LK., 2013, In : American Journal of Respiratory Cell and Molecular Biology. 48, 1, p. 135 - 144 10 p.

Research output: Contribution to journalArticleResearchpeer-review

45 Citations (Scopus)

Update on the angiotensin AT(2) receptor

McCarthy, C. A., Widdop, R. E., Denton, K. M. & Jones, E. S., 2013, In : Current Hypertension Reports. 15, 1, p. 25 - 30 6 p.

Research output: Contribution to journalArticleResearchpeer-review

34 Citations (Scopus)

Venom proteomic characterization and relative antivenom neutralization of two medically important Pakistani elapid snakes (Bungarus sindanus and Naja naja)

Ali, S. A., Yang, D., Jackson, T. N. W., Undheim, E. A. B., Koludarov, I., Wood, K., Jones, A., Hodgson, W. C., McCarthy, S., Ruder, T. & Fry, B. G., 2013, In : Journal of Proteomics. 89, p. 15 - 23 9 p.

Research output: Contribution to journalArticleResearchpeer-review

2012
123 Citations (Scopus)

Adiponectin receptor signalling in the brain

Thundyil, J., Pavlovski, D., Sobey, C. & Arumugam, T., 2012, In : British Journal of Pharmacology. 165, 2, p. 313 - 327 15 p.

Research output: Contribution to journalArticleResearchpeer-review

11 Citations (Scopus)

Aldosterone and the mineralocorticoid receptor in the cerebral circulation and stroke

Dinh, Q. N., Arumugam, T. V., Young, M. J., Drummond, G. R., Sobey, C. G. & Chrissobolis, S., 2012, In : Experimental & Translational Stroke Medicine. 4, 1 (Art. No.: 21), p. 1 - 21 21 p.

Research output: Contribution to journalArticleResearchpeer-review

48 Citations (Scopus)

Allosteric modulation of endogenous metabolites as an avenue for drug discovery

Wootten, D. L., Savage, E. E., Valant, C., May, L. T., Sloop, K. W., Ficorilli, J., Showalter, A. D., Willard, F. S., Christopoulos, A. & Sexton, P. M., 2012, In : Molecular Pharmacology. 82, 2, p. 281 - 290 10 p.

Research output: Contribution to journalArticleResearchpeer-review

162 Citations (Scopus)

Allosteric modulation of seven transmembrane spanning receptors: theory, practice, and opportunities for central nervous system drug discovery

Melancon, B. J., Hopkins, C. R., Wood, M. R., Emmitte, K. A., Niswender, C. M., Christopoulos, A., Conn, P. J. & Lindsley, C. W., 2012, In : Journal of Medicinal Chemistry. 55, 4, p. 1445 - 1464 20 p.

Research output: Contribution to journalArticleResearchpeer-review

84 Citations (Scopus)

A Monod-Wyman-Changeux mechanism can explain G protein-coupled receptor (GPCR) allosteric modulation

Canals, M., Lane, J., Wen, A., Scammells, P., Sexton, P. & Christopoulos, A., 2012, In : Journal of Biological Chemistry. 287, 1, p. 650 - 659 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Angiotensin II receptors and neuroprotection

Widdop, R. E., Steckelings, U. M., McCarthy, C. & Callaway, J. K., 1 Jan 2012, Neuropeptides in Neuroprotection and Neuroregeneration. Nyberg, F. J. (ed.). 1 ed. Boca Raton FL USA: CRC Press, p. 165-178 14 p.

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Researchpeer-review

40 Citations (Scopus)

Angiotensin II Type 2 receptor stimulation initiated after stroke causes neuroprotection in conscious rats

McCarthy, C. A., Vinh, A., Broughton, B. RS., Sobey, C. G., Callaway, J. K. & Widdop, R. E., 2012, In : Hypertension. 60, 6, p. 1531 - 1537 7 p.

Research output: Contribution to journalArticleResearchpeer-review

237 Citations (Scopus)

A simple method for quantifying functional selectivity and agonist bias

Kenakin, T., Watson, C., Muniz-Medina, V., Christopoulos, A. & Novick, S., 2012, In : ACS Chemical Neuroscience. 3, 3, p. 193 - 203 11 p.

Research output: Contribution to journalArticleResearchpeer-review

17 Citations (Scopus)

Beta(2)-adrenoceptors increase translocation of GLUT4 via GPCR kinase sites in the receptor C-terminal tail

Dehvari, N., Hutchinson, D., Nevzorova, J., Dallner, O., Sato, M., Kocan, M., Merlin, J., Evans, B., Summers, R. & Bengtsson, T., 2012, In : British Journal of Pharmacology. 165, 5, p. 1442 - 1456 15 p.

Research output: Contribution to journalArticleResearchpeer-review

13 Citations (Scopus)

Brain infarct volume after permanent focal ischemia is not dependent on Nox2 expression

Kim, H. A., Brait, V. H., Lee, S. S., De Silva, T. M., Diep, H., Mast, A., Drummond, G. R. & Sobey, C. G., 2012, In : Brain Research. 1483, p. 105 - 111 7 p.

Research output: Contribution to journalArticleResearchpeer-review

5 Citations (Scopus)

Chlamydia pneumoniae induces a pro-inflammatory phenotype in murine vascular smooth muscle cells independently of elevating reactive oxygen species

Rivera, J., Walduck, A. K., Strugnell, R. A., Sobey, C. G. & Drummond, G. R., 2012, In : Clinical and Experimental Pharmacology and Physiology. 39, 3, p. 218 - 226 9 p.

Research output: Contribution to journalArticleResearchpeer-review

13 Citations (Scopus)

Chronic treatment with tempol does not significantly ameliorate renal tissue hypoxia or disease progression in a rodent model of polycystic kidney disease

Ding, A., Kalaignanasundaram, P., Ricardo, S. D., Abdelkader, A., Witting, P. K., Broughton, B. RS., Kim, H. B., Wyse, B. F., Phillips, J. K. & Evans, R. G., 2012, In : Clinical and Experimental Pharmacology and Physiology. 39, 11, p. 917 - 929 13 p.

Research output: Contribution to journalArticleResearchpeer-review

7 Citations (Scopus)

Comparison of blood pressure and sympathetic activity of rabbits in their home cage and the laboratory environment

Lim, K. J., Burke, S. L., Armitage, J. A. & Head, G. A., 2012, In : Experimental Physiology. 97, 12, p. 1263 - 1271 9 p.

Research output: Contribution to journalArticleResearchpeer-review

27 Citations (Scopus)

Consequences of splice variation on secretin family G protein-coupled receptor function

Furness, S. G. B., Wootten, D. L., Christopoulos, A. & Sexton, P. M., 2012, In : British Journal of Pharmacology. 166, 1, p. 98 - 109 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
50 Citations (Scopus)

Cutting edge issues in autoimmune gastritis

Toh, B-H., Chan, C. & Alderuccio, F., 2012, In : Clinical Reviews in Allergy and Immunology. 42, p. 269 - 278 10 p.

Research output: Contribution to journalArticleResearchpeer-review

32 Citations (Scopus)

Design and receptor interactions of obligate dimeric mutant of chemokine monocyte chemoattractant protein-1 (MCP-1)

Tan Hoong Yu, J., Canals, M., Ludeman, J. P., Wedderburn, J., Boston, C., Butler, S. J., Carrick, A. M., Parody, T. R., Taleski, D., Christopoulos, A., Payne, R. J. & Stone, M. J., 2012, In : Journal of Biological Chemistry. 287, 18, p. 14692 - 14702 11 p.

Research output: Contribution to journalArticleResearchpeer-review

26 Citations (Scopus)

Differential mechanisms of ang (1-7)-mediated vasodepressor effect in adult and aged candesartan-treated rats

Bosnyak, S., Widdop, R. E., Denton, K. M. & Jones, E. S., 2012, In : International Journal of Hypertension. 2012, Art. No.192567, p. 1 - 9 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
23 Citations (Scopus)

Diffusive oxygen shunting between vessels in the preglomerular renal vasculature: anatomic observations and computational modeling

Gardiner, B. S., Thompson, S. L., Ngo, J. P., Smith, D. W., Abdelkader, A., Broughton, B. RS., Bertram, J. F. & Evans, R. G., 2012, In : American Journal of Physiology - Renal Physiology. 303, 5, p. F605 - F618 14 p.

Research output: Contribution to journalArticleResearchpeer-review

16 Citations (Scopus)

Engagement of students with lectures in biochemistry and pharmacology

Davis, E. A., Hodgson, Y. M. & Macaulay, J. O., 2012, In : Biochemistry and Molecular Biology Education. 40, 5, p. 300 - 309 10 p.

Research output: Contribution to journalArticleResearchpeer-review

4 Citations (Scopus)

Ganging up on Angiotensin II Type 1 Receptors in Vascular Remodeling

Gaspari, T. A., Vinh, A., Jones, E. S. & Widdop, R. E., 2012, In : Hypertension. 60, 1, p. 17 - 19 3 p.

Research output: Contribution to journalLetterOther

38 Citations (Scopus)

Glucagon-like peptide-1 receptor dimerization differentially regulates agonist signaling but does not affect small molecule allostery

Harikumar, K. G., Wootten, D. L., Pinon, D. I., Koole, C. R., Ball, A. M., Furness, S. GB., Graham, B., Dong, M., Christopoulos, A., Miller, L. J. & Sexton, P. M., 2012, In : Proceedings of the National Academy of Sciences. 109, 45, p. 18607 - 18612 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
15 Citations (Scopus)

Human relaxin-2: historical perspectives and role in cancer biology

Nair, V. B., Samuel, C. S., Separovic, F., Hossain, M. A. & Wade, J. D., 2012, In : Amino Acids. 43, 3, p. 1131 - 1140 10 p.

Research output: Contribution to journalArticleResearchpeer-review

16 Citations (Scopus)

Identification of key residues essential for the structural fold and receptor selectivity within the A-chain of human gene-2 (H2) relaxin

Chan, L. J., Rosengren, K. J., Layfield, S. L., Bathgate, R. A. D., Separovic, F., Samuel, C. S., Hossain, M. A. & Wade, J. D., 30 Nov 2012, In : Journal of Biological Chemistry. 287, 49, p. 41152-41164 13 p.

Research output: Contribution to journalArticleResearchpeer-review

46 Citations (Scopus)

Identification of molecular phenotypes and biased signaling induced by naturally occurring mutations of the human calcium-sensing receptor

Leach, K., Wen, C., Davey, A. E., Sexton, P. M., Conigrave, A. D. & Christopoulos, A., 2012, In : Endocrinology. 153, 9, p. 4304 - 4316 13 p.

Research output: Contribution to journalArticleResearchpeer-review

103 Citations (Scopus)

Importance of T lymphocytes in brain injury, immunodeficiency, and recovery after cerebral ischemia

Brait, V. H., Arumugam, T. V., Drummond, G. R. & Sobey, C. G., 2012, In : Journal of Cerebral Blood Flow and Metabolism. 32, 4, p. 598 - 611 14 p.

Research output: Contribution to journalArticleResearchpeer-review

16 Citations (Scopus)

Insulin-regulated aminopeptidase deficiency provides protection against ischemic stroke in mice

Pham, V., Albiston, A., Downes, C., Wong, C. H. Y., Diwakarla, L. P., Ng, L., Lee, S., Crack, P. & Chai, S., 2012, In : Journal of Neurotrauma. 29, 6, p. 1243 - 1248 6 p.

Research output: Contribution to journalArticleResearchpeer-review

18 Citations (Scopus)

Interaction with caveolin-1 modulates G protein coupling of the mouse beta3-adrenoceptor

Sato, M., Hutchinson, D. S., Halls, M. L., Furness, S. G. B., Bengtsson, T., Evans, B. A. & Summers, R. J., 2012, In : Journal of Biological Chemistry. 287, 24, p. 20674 - 20688 15 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
30 Citations (Scopus)

Intravenous immunoglobulin protects neurons against amyloid beta-peptide toxicity and ischemic stroke by attenuating multiple cell death pathways

Widiapradja, A., Vegh, V., Lok, K. Z., Manzanero, S., Thundyil, J., Gelderblom, M., Cheng, Y-L., Pavlovski, D., Tang, S-C., Jo, D-G., Magnus, T., Chan, S. L., Sobey, C. G., Reutens, D. C., Basta, M., Mattson, M. P. & Arumugam, T. V., 2012, In : Journal of Neurochemistry. 122, 2, p. 321 - 332 12 p.

Research output: Contribution to journalArticleResearchpeer-review

11 Citations (Scopus)

In vivo and in vitro cardiovascular effects of Papuan taipan (Oxyuranus scutellatus) venom: Exploring "sudden collapse"

Chaisakul, J., Isbister, G. K., Konstantakopoulos, N., Tare, M., Parkington, H. C. & Hodgson, W. C., 2012, In : Toxicology Letters. 213, 2, p. 243 - 248 6 p.

Research output: Contribution to journalArticleResearchpeer-review

130 Citations (Scopus)

Lifting the lid on GPCRs: the role of extracellular loops

Wheatley, M., Wootten, D. L., Conner, M., Simms, J. W., Kendrick, R., Logan, R. T., Poyner, D. R. & Barwell, J., 2012, In : British Journal of Pharmacology. 165, 6, p. 1688 - 1703 16 p.

Research output: Contribution to journalArticleResearchpeer-review

23 Citations (Scopus)

Mapping spatial approximations between the amino terminus of secretin and each of the extracellular loops of its receptor using cysteine trapping

Dong, M., Xu, X., Ball, A. M., Makhoul, J. A., Lam, P. CH., Pinon, D. I., Orry, A., Sexton, P. M., Abagyan, R. & Miller, L. J., 2012, In : FASEB Journal. 26, 12, p. 5092 - 5105 14 p.

Research output: Contribution to journalArticleResearchpeer-review

59 Citations (Scopus)

Minimization of human relaxin-3 leading to high-affinity analogues with increased selectivity for relaxin-family peptide 3 receptor (RXFP3) over RXFP1

Shabanpoor, F., Hossain, M. A., Ryan, P. J., Belgi, A., Layfield, S., Kocan, M., Zhang, S., Samuel, C. S., Gundlach, A. L., Bathgate, R. AD., Separovic, F. & Wade, J. D., 2012, In : Journal of Medicinal Chemistry. 55, 4, p. 1671 - 1681 11 p.

Research output: Contribution to journalArticleResearchpeer-review

14 Citations (Scopus)

Molecular basis for binding and subtype selectivity of 1,4-benzodiazepine antagonist ligands of the cholecystokinin receptor

Cawston, E. E., Lam, P. C. H., Harikumar, K. G., Dong, M., Ball, A. M., Augustine, M. L., Akgun, E., Portoghese, P. S., Orry, A., Abagyan, R., Sexton, P. M. & Miller, L., 2012, In : Journal of Biological Chemistry. 287, 22, p. 18618 - 18635 18 p.

Research output: Contribution to journalArticleResearchpeer-review

65 Citations (Scopus)

NADPH oxidases as regulators of tumor angiogenesis: current and emerging concepts

Coso, S., Harrison, I., Harrison, C., Vinh, A., Sobey, C., Drummond, G., Williams, E. & Selemidis, S., 2012, In : Antioxidants and Redox Signaling. 16, 11, p. 1229 - 1247 19 p.

Research output: Contribution to journalArticleResearchpeer-review

32 Citations (Scopus)

Neurocardiac dysregulation and neurogenic arrhythmias in a transgenic mouse model of Huntington's disease

Kiriazis, H., Jennings, N., Davern, P., Lambert, G., Su, Y., Pang, T., Du, X., La Greca, L., Head, G. A., Hannan, A. J. & Du, X. J., Nov 2012, In : The Journal of Physiology. 590, 22, p. 5845-5860 16 p.

Research output: Contribution to journalArticleResearchpeer-review

17 Citations (Scopus)

Neuromuscular activity of the venoms of the Colombian coral snakes Micrurus dissoleucus and Micrurus mipartitus: an evolutionary perspective

Renjifo, C., Smith, E. N., Hodgson, W. C., Renjifo, J. M., Sanchez, A., Acosta, R., Maldonado, J. H. & Riveros, A., 2012, In : Toxicon : official journal of the International Society on Toxinology. 59, 1, p. 132 - 142 11 p.

Research output: Contribution to journalArticleResearchpeer-review