Research Output 1986 2019

2012

Brain infarct volume after permanent focal ischemia is not dependent on Nox2 expression

Kim, H. A., Brait, V. H., Lee, S. S., De Silva, T. M., Diep, H., Mast, A., Drummond, G. R. & Sobey, C. G., 2012, In : Brain Research. 1483, p. 105 - 111 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Chlamydia pneumoniae induces a pro-inflammatory phenotype in murine vascular smooth muscle cells independently of elevating reactive oxygen species

Rivera, J., Walduck, A. K., Strugnell, R. A., Sobey, C. G. & Drummond, G. R., 2012, In : Clinical and Experimental Pharmacology and Physiology. 39, 3, p. 218 - 226 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Chronic treatment with tempol does not significantly ameliorate renal tissue hypoxia or disease progression in a rodent model of polycystic kidney disease

Ding, A., Kalaignanasundaram, P., Ricardo, S. D., Abdelkader, A., Witting, P. K., Broughton, B. RS., Kim, H. B., Wyse, B. F., Phillips, J. K. & Evans, R. G., 2012, In : Clinical and Experimental Pharmacology and Physiology. 39, 11, p. 917 - 929 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Comparison of blood pressure and sympathetic activity of rabbits in their home cage and the laboratory environment

Lim, K. J., Burke, S. L., Armitage, J. A. & Head, G. A., 2012, In : Experimental Physiology. 97, 12, p. 1263 - 1271 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Consequences of splice variation on secretin family G protein-coupled receptor function

Furness, S. G. B., Wootten, D. L., Christopoulos, A. & Sexton, P. M., 2012, In : British Journal of Pharmacology. 166, 1, p. 98 - 109 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Cutting edge issues in autoimmune gastritis

Toh, B-H., Chan, C. & Alderuccio, F., 2012, In : Clinical Reviews in Allergy and Immunology. 42, p. 269 - 278 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Design and receptor interactions of obligate dimeric mutant of chemokine monocyte chemoattractant protein-1 (MCP-1)

Tan Hoong Yu, J., Canals, M., Ludeman, J. P., Wedderburn, J., Boston, C., Butler, S. J., Carrick, A. M., Parody, T. R., Taleski, D., Christopoulos, A., Payne, R. J. & Stone, M. J., 2012, In : Journal of Biological Chemistry. 287, 18, p. 14692 - 14702 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Differential mechanisms of ang (1-7)-mediated vasodepressor effect in adult and aged candesartan-treated rats

Bosnyak, S., Widdop, R. E., Denton, K. M. & Jones, E. S., 2012, In : International Journal of Hypertension. 2012, Art. No.192567, p. 1 - 9 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Diffusive oxygen shunting between vessels in the preglomerular renal vasculature: anatomic observations and computational modeling

Gardiner, B. S., Thompson, S. L., Ngo, J. P., Smith, D. W., Abdelkader, A., Broughton, B. RS., Bertram, J. F. & Evans, R. G., 2012, In : American Journal of Physiology - Renal Physiology. 303, 5, p. F605 - F618 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Engagement of students with lectures in biochemistry and pharmacology

Davis, E. A., Hodgson, Y. M. & Macaulay, J. O., 2012, In : Biochemistry and Molecular Biology Education. 40, 5, p. 300 - 309 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Ganging up on Angiotensin II Type 1 Receptors in Vascular Remodeling

Gaspari, T. A., Vinh, A., Jones, E. S. & Widdop, R. E., 2012, In : Hypertension. 60, 1, p. 17 - 19 3 p.

Research output: Contribution to journalLetterOther

Glucagon-like peptide-1 receptor dimerization differentially regulates agonist signaling but does not affect small molecule allostery

Harikumar, K. G., Wootten, D. L., Pinon, D. I., Koole, C. R., Ball, A. M., Furness, S. GB., Graham, B., Dong, M., Christopoulos, A., Miller, L. J. & Sexton, P. M., 2012, In : Proceedings of the National Academy of Sciences. 109, 45, p. 18607 - 18612 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Human relaxin-2: historical perspectives and role in cancer biology

Nair, V. B., Samuel, C. S., Separovic, F., Hossain, M. A. & Wade, J. D., 2012, In : Amino Acids. 43, 3, p. 1131 - 1140 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Identification of key residues essential for the structural fold and receptor selectivity within the A-chain of human gene-2 (H2) relaxin

Chan, L. J., Rosengren, K. J., Layfield, S. L., Bathgate, R. A. D., Separovic, F., Samuel, C. S., Hossain, M. A. & Wade, J. D., 30 Nov 2012, In : Journal of Biological Chemistry. 287, 49, p. 41152-41164 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Identification of molecular phenotypes and biased signaling induced by naturally occurring mutations of the human calcium-sensing receptor

Leach, K., Wen, C., Davey, A. E., Sexton, P. M., Conigrave, A. D. & Christopoulos, A., 2012, In : Endocrinology. 153, 9, p. 4304 - 4316 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Importance of T lymphocytes in brain injury, immunodeficiency, and recovery after cerebral ischemia

Brait, V. H., Arumugam, T. V., Drummond, G. R. & Sobey, C. G., 2012, In : Journal of Cerebral Blood Flow and Metabolism. 32, 4, p. 598 - 611 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Insulin-regulated aminopeptidase deficiency provides protection against ischemic stroke in mice

Pham, V., Albiston, A., Downes, C., Wong, C. H. Y., Diwakarla, L. P., Ng, L., Lee, S., Crack, P. & Chai, S., 2012, In : Journal of Neurotrauma. 29, 6, p. 1243 - 1248 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Interaction with caveolin-1 modulates G protein coupling of the mouse beta3-adrenoceptor

Sato, M., Hutchinson, D. S., Halls, M. L., Furness, S. G. B., Bengtsson, T., Evans, B. A. & Summers, R. J., 2012, In : Journal of Biological Chemistry. 287, 24, p. 20674 - 20688 15 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File

Intravenous immunoglobulin protects neurons against amyloid beta-peptide toxicity and ischemic stroke by attenuating multiple cell death pathways

Widiapradja, A., Vegh, V., Lok, K. Z., Manzanero, S., Thundyil, J., Gelderblom, M., Cheng, Y-L., Pavlovski, D., Tang, S-C., Jo, D-G., Magnus, T., Chan, S. L., Sobey, C. G., Reutens, D. C., Basta, M., Mattson, M. P. & Arumugam, T. V., 2012, In : Journal of Neurochemistry. 122, 2, p. 321 - 332 12 p.

Research output: Contribution to journalArticleResearchpeer-review

In vivo and in vitro cardiovascular effects of Papuan taipan (Oxyuranus scutellatus) venom: Exploring "sudden collapse"

Chaisakul, J., Isbister, G. K., Konstantakopoulos, N., Tare, M., Parkington, H. C. & Hodgson, W. C., 2012, In : Toxicology Letters. 213, 2, p. 243 - 248 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Lifting the lid on GPCRs: the role of extracellular loops

Wheatley, M., Wootten, D. L., Conner, M., Simms, J. W., Kendrick, R., Logan, R. T., Poyner, D. R. & Barwell, J., 2012, In : British Journal of Pharmacology. 165, 6, p. 1688 - 1703 16 p.

Research output: Contribution to journalArticleResearchpeer-review

Mapping spatial approximations between the amino terminus of secretin and each of the extracellular loops of its receptor using cysteine trapping

Dong, M., Xu, X., Ball, A. M., Makhoul, J. A., Lam, P. CH., Pinon, D. I., Orry, A., Sexton, P. M., Abagyan, R. & Miller, L. J., 2012, In : FASEB Journal. 26, 12, p. 5092 - 5105 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Minimization of human relaxin-3 leading to high-affinity analogues with increased selectivity for relaxin-family peptide 3 receptor (RXFP3) over RXFP1

Shabanpoor, F., Hossain, M. A., Ryan, P. J., Belgi, A., Layfield, S., Kocan, M., Zhang, S., Samuel, C. S., Gundlach, A. L., Bathgate, R. AD., Separovic, F. & Wade, J. D., 2012, In : Journal of Medicinal Chemistry. 55, 4, p. 1671 - 1681 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Molecular basis for binding and subtype selectivity of 1,4-benzodiazepine antagonist ligands of the cholecystokinin receptor

Cawston, E. E., Lam, P. C. H., Harikumar, K. G., Dong, M., Ball, A. M., Augustine, M. L., Akgun, E., Portoghese, P. S., Orry, A., Abagyan, R., Sexton, P. M. & Miller, L., 2012, In : Journal of Biological Chemistry. 287, 22, p. 18618 - 18635 18 p.

Research output: Contribution to journalArticleResearchpeer-review

NADPH oxidases as regulators of tumor angiogenesis: current and emerging concepts

Coso, S., Harrison, I., Harrison, C., Vinh, A., Sobey, C., Drummond, G., Williams, E. & Selemidis, S., 2012, In : Antioxidants and Redox Signaling. 16, 11, p. 1229 - 1247 19 p.

Research output: Contribution to journalArticleResearchpeer-review

Neurocardiac dysregulation and neurogenic arrhythmias in a transgenic mouse model of Huntington's disease

Kiriazis, H., Jennings, N., Davern, P., Lambert, G., Su, Y., Pang, T., Du, X., La Greca, L., Head, G. A., Hannan, A. J. & Du, X. J., Nov 2012, In : The Journal of Physiology. 590, 22, p. 5845-5860 16 p.

Research output: Contribution to journalArticleResearchpeer-review

Neuromuscular activity of the venoms of the Colombian coral snakes Micrurus dissoleucus and Micrurus mipartitus: an evolutionary perspective

Renjifo, C., Smith, E. N., Hodgson, W. C., Renjifo, J. M., Sanchez, A., Acosta, R., Maldonado, J. H. & Riveros, A., 2012, In : Toxicon : official journal of the International Society on Toxinology. 59, 1, p. 132 - 142 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Neuroprotective effect of an angiotensin receptor type 2 agonist following cerebral ischemia in vitro and in vivo

Lee, S., Brait, V. H., Arumugam, T., Evans, M. A., Kim, H. H. A., Widdop, R. E., Drummond, G. R., Sobey, C. G. & Jones, E. S., 2012, In : Experimental & Translational Stroke Medicine. 4, 1 (Art. No.: 16), p. 1 - 9 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Nitroxyl (HNO) stimulates soluble guanylyl cyclase to suppress cardiomyocyte hypertrophy and superoxide generation

Lin, E., Irvine, J. C., Cao, A. H., Alexander, A. E., Love, J. E., Patel, R., McMullen, J. R., Kaye, D. M., Kemp-Harper, B. K. & Ritchie, R. H., 2012, In : PLoS ONE. 7, 4, 11 p., e34892.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

NOX2 beta: A novel splice variant of NOX2 that regulates NADPH oxidase activity in macrophages

Harrison, C. B., Selemidis, S., Guida, E., King, P. T., Sobey, C. G. & Drummond, G. R., 2012, In : PLoS ONE. 7, 10, 14 p., e48326.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Over-expression of DSCR1 protects against post-ischemic neuronal injury

Brait, V. H., Martin, K. R., Corlett, A. R. I., Broughton, B. RS., Kim, H., Thundyil, J., Drummond, G. R., Arumugam, T. V., Pritchard, M. A. & Sobey, C. G., 2012, In : PLoS ONE. 7, 10, 8 p., e47841.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File

Positive and negative allosteric modulators promote biased signaling at the calcium-sensing receptor

Davey, A. E., Leach, K., Valant, C., Conigrave, A. D., Sexton, P. M. & Christopoulos, A., 2012, In : Endocrinology. 153, 3, p. 1232 - 1241 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Ramp

Hay, D. L., Sexton, P. M. & Poyner, D. R., 2012, Encyclopedia of Signaling Molecules. Choi, S. (ed.). New York NY USA: Springer, p. 1570-1574 5 p.

Research output: Chapter in Book/Report/Conference proceedingEncyclopaedia / Dictionary EntryOtherpeer-review

RAMPs and CGRP receptors

Barwell, J., Wootten, D., Simms, J., Hay, D. L. & Poyner, D. R., 2012, RAMPs. Spielman, W. S. & Parameswaran, N. (eds.). New York NY USA: Springer, Vol. 744. p. 13-24 12 p. (Advances in Experimental Medicine and Biology; vol. 744).

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Otherpeer-review

RAMPs as drug targets

Sexton, P. M., Poyner, D. R., Simms, J., Christopoulos, A. & Hay, D. L., 2012, RAMPs. Spielman, W. S. & Parameswaran, N. (eds.). 1st ed. USA: Springer, p. 61 - 74 14 p.

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Researchpeer-review

Rapid onset of renal sympathetic nerve activation in rabbits fed a high-fat diet

Armitage, J. A., Burke, S. L., Prior, L. J., Barzel, B., Eikelis, N., Lim, K. J. & Head, G. A., 2012, In : Hypertension. 60, 1, p. 163 - 171 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Rapid turnover of glycogen in memory formation

Gibbs, M. E. & Hutchinson, D. S., 2012, In : Neurochemical Research. 37, 11, p. 2456 - 2463 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Relaxin: An emerging therapy for fibroproliferative disorders

Samuel, C. S., 2012, Dupuytren's Disease and Related Hyperproliferative Disorders. Eaton, C., Seegenschmiedt, M. H., Bayat, A., Gabbiani, G., Werker, P. M. N. & Wach, W. (eds.). 1st ed. Germany: Springer, p. 393 - 400 8 p.

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Researchpeer-review

Relaxin signals through a RXFP1-pERK-nNOS-NO-cGMP-dependent pathway to up-regulate matrix metalloproteinases: the additional involvement of iNOS

Chow, B. SM., Chew, E. GY., Zhao, C., Bathgate, R. AD., Hewitson, T. D. & Samuel, C. S., 2012, In : PLoS ONE. 7, 8, 13 p., e42714.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File

Renal sympathetic activation from long-term low-dose angiotensin II infusion in rabbits

Moretti, J-L., Burke, S. L., Davern, P. J., Evans, R. G., Lambert, G. W. & Head, G. A., 2012, In : Journal of hypertension. 30, 3, p. 551 - 560 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Reversal of vascular macrophage accumulation and hypertension by a CCR2 antagonist in deoxycorticosterone/salt-treated mice

Chan, C., Moore, J., Budzyn, K., Guida, E., Diep, H., Vinh, A., Jones, E. S., Widdop, R. E., Armitage, J. A., Sakkal, S., Ricardo, S. D., Sobey, C. G. & Drummond, G. R., 2012, In : Hypertension. 60, 5, p. 1207 - 1212 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Role of Nox isoforms in angiotensin II-induced oxidative stress and endothelial dysfunction in brain

Chrissobolis, S., Banfi, B., Sobey, C. G. & Faraci, F. M., 2012, In : Journal of Applied Physiology. 113, 2, p. 184 - 191 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Second extracellular loop of human glucagon-like peptide-1 receptor (GLP-1R) differentially regulates orthosteric but not allosteric agonist binding and function

Koole, C. R., Wootten, D. L., Simms, J., Savage, E. E., Miller, L. J., Christopoulos, A. & Sexton, P. M., 2012, In : Journal of Biological Chemistry. 287, 6, p. 3659 - 3673 15 p.

Research output: Contribution to journalArticleResearchpeer-review

Second extracellular loop of human glucagon-like peptide-1 receptor (GLP-1R) has a critical role in GLP-1 peptide binding and receptor activation

Koole, C. R., Wootten, D. L., Simms, J. W., Miller, L. J., Christopoulos, A. & Sexton, P., 2012, In : Journal of Biological Chemistry. 287, 6, p. 3642 - 3658 17 p.

Research output: Contribution to journalArticleResearchpeer-review

Sex differences in the pressor and tubuloglomerular feedback response to angiotensin II

Brown, R. D., Hilliard, L. M., Head, G. A., Jones, E. S., Widdop, R. E. & Denton, K. M., 2012, In : Hypertension. 59, 1, p. 129 - 135 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Sex-specific influence of angiotensin type 2 receptor stimulation on renal function: a novel therapeutic target for hypertension

Hilliard, L. M., Jones, E. S., Steckelings, U. M., Unger, T., Widdop, R. E. & Denton, K. M., 2012, In : Hypertension. 59, 2, p. 409 - 414 6 p.

Research output: Contribution to journalArticleResearchpeer-review