Research Output 1986 2020

2013
14 Citations (Scopus)

Comment on "protective arms of the renin-angiotensin system in neurological disease": Reply

Sumners, C., Horiuchi, M., Widdop, R. E., Mccarthy, C., Unger, T. & Steckelings, U. M., Nov 2013, In : Clinical and Experimental Pharmacology and Physiology. 40, 11, p. 838-839 2 p.

Research output: Contribution to journalLetterOtherpeer-review

13 Citations (Scopus)

Cross-neutralisation of the neurotoxic effects of Egyptian cobra venom with commercial tiger snake antivenom

Kornhauser, R. S., Isbister, G. K., O'Leary, M. A., Mirtschin, P., Dunstan, N. & Hodgson, W. C., 2013, In : Basic and Clinical Pharmacology and Toxicology. 112, 2, p. 138 - 143 6 p.

Research output: Contribution to journalArticleResearchpeer-review

1 Citation (Scopus)

Development of human cells with RXFP1 knockdown using retroviral delivery of microRNA against human RXFP1

Yong, K. J., Callander, G. E., Bergin, R., Samuel, C. S. & Bathgate, R. A. D., 2013, In : Italian Journal of Anatomy and Embryology. 118, 1 SUPPL., p. 10-12 3 p.

Research output: Contribution to journalArticleOtherpeer-review

53 Citations (Scopus)

Development of M1 mAChR allosteric and bitopic ligands: Prospective therapeutics for the treatment of cognitive deficits

Davie, B. J., Christopoulos, A. & Scammells, P. J., 2013, In : ACS Chemical Neuroscience. 4, 7, p. 1026 - 1048 23 p.

Research output: Contribution to journalArticleResearchpeer-review

52 Citations (Scopus)

Differential activation and modulation of the glucagon-like peptide-1 receptor by small molecule ligands

Wootten, D. L., Savage, E. E., Willard, F. S., Bueno, A. B., Sloop, K. W., Christopoulos, A. & Sexton, P., 2013, In : Molecular Pharmacology. 83, 4, p. 822 - 834 13 p.

Research output: Contribution to journalArticleResearchpeer-review

47 Citations (Scopus)

Differential evolution and neofunctionalization of snake venom metalloprotease domains

Brust, A., Sunagar, K., Undheim, E. A. B., Vetter, I., Yang, D., Casewell, N. R., Jackson, T. N. W., Koludarov, I., Alewood, P. F., Hodgson, W. C., Lewis, R. J., King, G. F., Antunes, A., Hendrikx, I. & Fry, B. G., 2013, In : Molecular & Cellular Proteomics. 12, 3, p. 651 - 663 13 p.

Research output: Contribution to journalArticleResearchpeer-review

4 Citations (Scopus)
20 Citations (Scopus)

Direct AT{2} receptor stimulation is athero-protective and stabilizes plaque in Apolipoprotein E-deficient mice

Tesanovic Kljajic, S., Widdop, R. E., Vinh, A., Welungoda, I. K., Bosnyak, S., Jones, E. S. & Gaspari, T. A., 2013, In : International Journal of Cardiology. 169, 4, p. 281 - 287 7 p.

Research output: Contribution to journalArticleResearchpeer-review

7 Citations (Scopus)

Does a nephron deficit exacerbate the renal and cardiovascular effects of obesity?

Gurusinghe, S., Brown, R. D., Cai, X., Samuel, C. S., Ricardo, S. D., Thomas, M. C. & Kett, M. M., 2013, In : PLoS ONE. 8, 9, 8 p., e73095.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
226 Citations (Scopus)

Emerging paradigms in GPCR allostery: implications for drug discovery

Wootten, D. L., Christopoulos, A. & Sexton, P., 2013, In : Nature Reviews Drug Discovery. 12, 8, p. 630 - 644 15 p.

Research output: Contribution to journalArticleResearchpeer-review

17 Citations (Scopus)

Endogenous ghrelin's role in hippocampal neuroprotection after global cerebral ischemia: does endogenous ghrelin protect against global stroke?

Kenny, R., Cai, G., Bayliss, J., Clarke, M., Choo, Y. L., Miller, A. A., Andrews, Z. B. & Spencer, S., 2013, In : American Journal of Physiology - Regulatory Integrative and Comparative Physiology. 304, 11, p. 980 - 990 11 p.

Research output: Contribution to journalArticleResearchpeer-review

9 Citations (Scopus)

Endothelial dysfunction in patients with type 2 diabetes post acute coronary syndrome

Lumsden, N. G., Andrews, K. L., Bobadilla, M., Moore, X. L., Sampson, A. K., Shaw, J. A., Mizrahi, J., Kaye, D. M., Dart, A. M. & Chin-Dusting, J. P. F., Jul 2013, In : Diabetes and Vascular Disease Research. 10, 4, p. 368-374 7 p.

Research output: Contribution to journalArticleResearchpeer-review

25 Citations (Scopus)

Enhanced depolarization-induced pulmonary vasoconstriction following chronic hypoxia requires EGFR-dependent activation of NAD(P)H oxidase 2

Norton, C. E., Broughton, B. RS., Jernigan, N. L., Walker, B. R. & Resta, T. C., 2013, In : Antioxidants and Redox Signaling. 18, 14, p. 1777 - 1788 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Erratum: Differential activation and modulation of the glucagon-like peptide-1 receptor by small molecular ligands (Molecular Pharmacology (2013) 83 (822-834))

Wootten, D., Savage, E. E., Willard, F. S., Bueno, A. B., Sloop, K. W., Christopoulos, A. & Sexton, P. M., Jul 2013, In : Molecular Pharmacology. 84, 1, p. 170 1 p.

Research output: Contribution to journalComment / DebateOtherpeer-review

1 Citation (Scopus)

Erratum - Differential evolution and neofunctionalization of snake venom metalloprotease domains (Molecular and Cellular Proteomics 2013, 12, (651-663))

Brust, A., Sunagar, K., Undheim, E. A. B., Vetter, I., Yang, D. C., Casewell, N. R., Jackson, T. N. W., Koludarov, I., Alewood, P. F., Hodgson, W. C., Lewis, R. J., King, G. F., Antunes, A., Hendrikx, I. & Fry, B. G., May 2013, In : Molecular & Cellular Proteomics. 12, 5, p. 1488 1 p.

Research output: Contribution to journalComment / DebateOtherpeer-review

18 Citations (Scopus)

Evidence for a detrimental role of TLR8 in ischemic stroke

Tang, S-C., Yeh, S-J., Li, Y., Wang, Y-C. W., Baik, S-H., Santro, T., Widiapradja, A., Manzanero, S., Sobey, C. G., Jo, D-G., Arumugam, T. & Jeng, J-S., 2013, In : Experimental Neurology. 250, p. 341 - 347 7 p.

Research output: Contribution to journalArticleResearchpeer-review

26 Citations (Scopus)

Evidence that the EphA2 receptor exacerbates ischemic brain injury

Thundyil, J., Manzanero, S., Pavlovski, D., Cully, T. R., Lok, K-Z., Widiapradja, A., Chunduri, P., Jo, D-G., Asano, M., Launikonis, B. S., Sobey, C. G., Coulthard, M. G. & Arumugam, T., 2013, In : PLoS ONE. 8, 1, 8 p., e53528.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
33 Citations (Scopus)

Glutathione peroxidase-1 reduces influenza A virus-induced lung inflammation

Yatmaz, S., Seow, H. J., Gualano, R. C., Wong, Z. X., Stambas, J., Selemidis, S., Crack, P. J., Bozinovski, S., Anderson, G. & Vlahos, R., 2013, In : American Journal of Respiratory Cell and Molecular Biology. 48, 1, p. 17 - 26 10 p.

Research output: Contribution to journalArticleResearchpeer-review

17 Citations (Scopus)

HNO/cGMP-dependent antihypertrophic actions of isopropylamine-NONOate in neonatal rat cardiomyocytes: potential therapeutic advantages of HNO over NO

Irvine, J. C., Cao, N., Gossain, S., Alexander, A. E., Love, J. E., Qin, C., Horowitz, J. D., Harper, B. K. & Ritchie, R. H., 2013, In : American Journal of Physiology - Heart and Circulatory Physiology. 305, 3, p. 365 - 377 13 p.

Research output: Contribution to journalArticleResearchpeer-review

17 Citations (Scopus)

Impact of chronic congestive heart failure on pharmacokinetics and vasomotor effects of infused nitrite

Maher, A. R., Arif, S., Madhani, M., Abozguia, K., Ahmed, I., Fernandez, B. O., Feelisch, M., O'Sullivan, A. G., Christopoulos, A., Sverdlov, A. L., Ngo, D., Dautov, R., James, P. E., Horowitz, J. D. & Frenneaux, M. P., 2013, In : British Journal of Pharmacology. 169, 3, p. 659 - 670 12 p.

Research output: Contribution to journalArticleResearchpeer-review

49 Citations (Scopus)

Impact of clinically relevant mutations on the pharmacoregulation and signaling bias of the calcium-sensing receptor by positive and negative allosteric modulators

Leach, K., Wen, C., Cook, A. E., Sexton, P., Conigrave, A. & Christopoulos, A., 2013, In : Endocrinology. 154, 3, p. 1105 - 1116 12 p.

Research output: Contribution to journalArticleResearchpeer-review

87 Citations (Scopus)

Inhibition of tumor angiogenesis and growth by a small-molecule multi-FGF receptor blocker with allosteric properties

Bono, F., De Smet, F., Herbert, C., De Bock, K., Georgiadou, M., Fons, P., Tjwa, M., Alcouffe, C., Ny, A., Bianciotto, M., Jonckx, B., Murakami, M., Lanahan, A. A., Michielsen, C., Sibrac, D., Dol-Gleizes, F., Mazzone, M., Zacchigna, S., Herault, J-P., Fischer, C. & 33 others, Rigon, P., Ruiz de Almodovar, C., Claes, F., Blanc, I., Poesen, K., Zhang, Z., Segura, I., Gueguen, G., Bordes, M-F., Lambrechts, D., Broussy, R., van de Wouwer, M., Michaux, C., Shimada, T., Jean, I., Blacher, S., Noel, A., Motte, P., Rom, E., Rakic, J-M., Katsuma, S., Schaeffer, P., Yayon, A., Van Schepdael, A., Schwalbe, H., Gervasio, F. L., Carmeliet, G., Rozensky, J., Dewerchin, M., Simons, M., Christopoulos, A., Herbert, J-M. & Carmeliet, P., 2013, In : Cancer Cell. 23, 4, p. 477 - 488 12 p.

Research output: Contribution to journalArticleResearchpeer-review

177 Citations (Scopus)

Intravenous immunoglobulin suppresses NLRP1 and NLRP3 inflammasome-mediated neuronal death in ischemic stroke

Fann, Y-W., Lee, S-Y., Manzanero, S., Tang, S-C., Gelderblom, M., Chunduri, P., Bernreuther, C., Glatzel, M., Cheng, Y-L., Thundyil, J., Widiapradja, A., Lok, K-Z., Foo, S. L., Wang, Y-C. W., Li, Y-I., Drummond, G. R., Basta, M., Magnus, T., Jo, D-G., Mattson, M. P. & 2 others, Sobey, C. G. & Arumugam, T., 2013, In : Cell Death and Disease. 4, 9 (Art. No.: e790), p. 1 - 10 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
7 Citations (Scopus)
37 Citations (Scopus)

Measurements of ligand bias and functional affinity

Kenakin, T. & Christopoulos, A., 2013, In : Nature Reviews Drug Discovery. 12, 6, p. 483 - 483 1 p.

Research output: Contribution to journalLetterOther

23 Citations (Scopus)

Minireview: Signal bias, allosterism, and polymorphic variation at the GLP-1R: implications for drug discovery

Koole, C. R., Savage, E. E., Christopoulos, A., Miller, L. J., Sexton, P. & Wootten, D. L., 2013, In : Molecular Endocrinology. 27, 8, p. 1234 - 1244 11 p.

Research output: Contribution to journalArticleResearchpeer-review

11 Citations (Scopus)

Molecular basis for benzodiazepine agonist action at the type 1 cholecystokinin receptor

Harikumar, K. G., Cawston, E. E., Lam, P. C. H., Patil, A., Orry, A., Henke, B., Abagyan, R., Christopoulos, A., Sexton, P. & Miller, L. J., 2013, In : Journal of Biological Chemistry. 288, 29, p. 21082 - 21095 14 p.

Research output: Contribution to journalArticleResearchpeer-review

101 Citations (Scopus)

Multiphoton imaging reveals a new leukocyte recruitment paradigm in the glomerulus

Devi, S., Li, A., Westhorpe, C. L., Lo, C. Y-W., Abeynaike, L., Snelgrove, S. L., Hall, P. H., Ooi, J., Sobey, C. G., Kitching, A. R. & Hickey, M. J., 2013, In : Nature Medicine. 19, 1, p. 107 - 112 6 p.

Research output: Contribution to journalArticleResearchpeer-review

16 Citations (Scopus)

Nitroxyl (HNO) suppresses vascular Nox2 oxidase activity

Miller, A. A., Maxwell, K., Chrissobolis, S., Bullen, M. L., Ku, J., De Silva, T. M., Selemidis, S., Hooker, E. U., Drummond, G. R., Sobey, C. G. & Kemp, B. K., 2013, In : Free Radical Biology and Medicine. 60, p. 264 - 271 8 p.

Research output: Contribution to journalArticleResearchpeer-review

7 Citations (Scopus)

Nitroxyl donors retain their depressor effects in hypertension

Irvine, J. C., Ravi, R. M., Harper, B. K. & Widdop, R. E., 2013, In : American Journal of Physiology - Heart and Circulatory Physiology. 305, 6, p. 939 - 945 7 p.

Research output: Contribution to journalArticleResearchpeer-review

26 Citations (Scopus)

Nox1 oxidase suppresses influenza a virus-induced lung inflammation and oxidative stress

Selemidis, S., Seow, H. J., Broughton, B. R. S., Vinh, A., Bozinovski, S., Sobey, C. G., Drummond, G. R. & Vlahos, R., 2013, In : PLoS ONE. 8, 4, 12 p., e60792.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
57 Citations (Scopus)

Obesity-related hypertension and the role of insulin and leptin in high-fat-fed rabbits

Lim, K. J., Burke, S. L. & Head, G. A., 2013, In : Hypertension. 61, 3, p. 628 - 634 7 p.

Research output: Contribution to journalArticleResearchpeer-review

162 Citations (Scopus)

Obesity results in progressive atrial structural and electrical remodeling: implications for atrial fibrillation

Abed, H. S., Samuel, C. S., Lau, D. H., Kelly, D. J., Royce, S. G., Alasady, M., Mahajan, R., Kuklik, P., Zhang, Y. M., Brooks, A. G., Nelson, A. J., Worthley, S. G., Abhayaratna, W., Kalman, J., Wittert, G. G. & Sanders, P., 2013, In : Heart Rhythm. 10, 1, p. 90 - 100 11 p.

Research output: Contribution to journalArticleResearchpeer-review

5 Citations (Scopus)

Orthosteric binding of rho-Da1a, a natural peptide of snake venom interacting selectively with the alpha(1A)-Adrenoceptor

Maiga, A., Merlin, J., Marcon, E., Rouget, C., Larregola, M., Gilquin, B., Fruchart-Gaillard, C., Lajeunesse, E., Marchetti, C., Lorphelin, A., Bellanger, L., Summers, R. J., Hutchinson, D. S., Evans, B. A., Servent, D. & Gilles, N., 2013, In : PLoS ONE. 8, 7, 11 p., e68841.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
118 Citations (Scopus)

Pathogenesis of acute stroke and the role of inflammasomes

Fann, D. Y-W., Lee, S-Y., Manzanero, S., Chunduri, P., Sobey, C. G. & Arumugam, T., 2013, In : Ageing Research Reviews. 12, 4, p. 941 - 966 26 p.

Research output: Contribution to journalArticleResearchpeer-review

2 Citations (Scopus)

Phenotyping dividing cells in mouse models of neurodegenerative basal ganglia diseases

Smardencas, A., Rizkalla, K., Kim, H. A., Massalas, J. S., O'Leary, C., Ehrlich, M. E., Schutz, G., Lawrence, A. J. & Drago, J., 2013, In : BMC Neuroscience. 14, Art. No.: 111, p. 1 - 19 19 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
93 Citations (Scopus)

Polar transmembrane interactions drive formation of ligand-specific and signal pathway-biased family B G protein-coupled receptor conformations

Wootten, D. L., Simms, J. W., Miller, L. J., Christopoulos, A. & Sexton, P., 2013, In : Proceedings of the National Academy of Sciences. 110, 13, p. 5211 - 5216 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
19 Citations (Scopus)

Population divergence in venom bioactivities of elapid snake Pseudonaja textilis: role of procoagulant proteins in rapid rodent prey incapacitation

Skejic, J. & Hodgson, W. C., 2013, In : PLoS ONE. 8, 5 (Art. ID: e63988), p. 1 - 10 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
25 Citations (Scopus)
Open Access
13 Citations (Scopus)

Probing structural requirements of positive allosteric modulators of the M4 muscarinic receptor

Huynh, T., Valant, C., Crosby, I. T., Sexton, P., Christopoulos, A. & Capuano, B., 2013, In : Journal of Medicinal Chemistry. 56, 20, p. 8196 - 8200 5 p.

Research output: Contribution to journalArticleResearchpeer-review

46 Citations (Scopus)

Protective arms of the renin-angiotensin-system in neurological disease

Sumners, C., Horiuchi, M., Widdop, R. E., McCarthy, C. A., Unger, T. & Steckelings, U. M., 2013, In : Clinical and Experimental Pharmacology and Physiology. 40, 8, p. 580 - 588 9 p.

Research output: Contribution to journalArticleResearchpeer-review

44 Citations (Scopus)

Recent advances in understanding GLP-1R (glucagon-like peptide-1 receptor) function

Koole, C. R., Pabreja, K., Savage, E. E., Wootten, D. L., Furness, S. G. B., Miller, L. J., Christopoulos, A. & Sexton, P., 2013, In : Biochemical Society Transactions. 41, 1, p. 172 - 179 8 p.

Research output: Contribution to journalArticleResearchpeer-review

10 Citations (Scopus)

Reduced preprandial dipping accounts for rapid elevation of blood pressure and renal sympathetic nerve activity in rabbits fed a high-fat diet

Burke, S. L., Prior, L. J., Lukoshkova, E. V., Lim, K., Barzel, B., Davern, P. J., Armitage, J. & Head, G. A., 2013, In : Chronobiology International. 30, 5, p. 726 - 738 13 p.

Research output: Contribution to journalArticleResearchpeer-review

29 Citations (Scopus)

Regulation of G protein-coupled receptors by allosteric ligands

Lane, J. R. D., Abdul Ridha, A. & Canals, M., 2013, In : ACS Chemical Neuroscience. 4, 4, p. 527 - 534 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Relaxin and its role in fibrotic diseases

Chan, L. J., Samuel, C. S., Separovic, F., Hossain, M. A. & Wade, J. D., 2013, Amino Acids, Peptides and Proteins. Farkas, E. & Ryadnov, M. (eds.). 1st ed. UK: RSC Publishing, p. 60 - 78 19 p.

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Researchpeer-review

249 Citations (Scopus)

Relaxin family peptides and their receptors

Bathgate, R., Halls, M. L., van der Westhuizen, E. T., Callander, G., Kocan, M. & Summers, R. J., 2013, In : Physiological Reviews. 93, 1, p. 405 - 480 76 p.

Research output: Contribution to journalArticleResearchpeer-review

427 Citations (Scopus)

Signalling bias in new drug discovery: detection, quantification and therapeutic impact

Kenakin, T. & Christopoulos, A., 2013, In : Nature Reviews Drug Discovery. 12, 3, p. 205 - 216 12 p.

Research output: Contribution to journalArticleResearchpeer-review

12 Citations (Scopus)

Species differences in the neuromuscular activity of post-synaptic neurotoxins from two Australian black snakes (Pseudechis porphyriacus and Pseudechis colletti)

Hart, A. J., Isbister, G. K., O'Donnell, P., Williamson, N. A. & Hodgson, W. C., 2013, In : Toxicology Letters. 219, 3, p. 262 - 268 7 p.

Research output: Contribution to journalArticleResearchpeer-review