Research Output 1986 2019

2013

Intravenous immunoglobulin suppresses NLRP1 and NLRP3 inflammasome-mediated neuronal death in ischemic stroke

Fann, Y-W., Lee, S-Y., Manzanero, S., Tang, S-C., Gelderblom, M., Chunduri, P., Bernreuther, C., Glatzel, M., Cheng, Y-L., Thundyil, J., Widiapradja, A., Lok, K-Z., Foo, S. L., Wang, Y-C. W., Li, Y-I., Drummond, G. R., Basta, M., Magnus, T., Jo, D-G., Mattson, M. P. & 2 othersSobey, C. G. & Arumugam, T., 2013, In : Cell Death and Disease. 4, 9 (Art. No.: e790), p. 1 - 10 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Measurements of ligand bias and functional affinity

Kenakin, T. & Christopoulos, A., 2013, In : Nature Reviews Drug Discovery. 12, 6, p. 483 - 483 1 p.

Research output: Contribution to journalLetterOther

Minireview: Signal bias, allosterism, and polymorphic variation at the GLP-1R: implications for drug discovery

Koole, C. R., Savage, E. E., Christopoulos, A., Miller, L. J., Sexton, P. & Wootten, D. L., 2013, In : Molecular Endocrinology. 27, 8, p. 1234 - 1244 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Molecular basis for benzodiazepine agonist action at the type 1 cholecystokinin receptor

Harikumar, K. G., Cawston, E. E., Lam, P. C. H., Patil, A., Orry, A., Henke, B., Abagyan, R., Christopoulos, A., Sexton, P. & Miller, L. J., 2013, In : Journal of Biological Chemistry. 288, 29, p. 21082 - 21095 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Multiphoton imaging reveals a new leukocyte recruitment paradigm in the glomerulus

Devi, S., Li, A., Westhorpe, C. L., Lo, C. Y-W., Abeynaike, L., Snelgrove, S. L., Hall, P. H., Ooi, J., Sobey, C. G., Kitching, A. R. & Hickey, M. J., 2013, In : Nature Medicine. 19, 1, p. 107 - 112 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Nitroxyl (HNO) suppresses vascular Nox2 oxidase activity

Miller, A. A., Maxwell, K., Chrissobolis, S., Bullen, M. L., Ku, J., De Silva, T. M., Selemidis, S., Hooker, E. U., Drummond, G. R., Sobey, C. G. & Kemp, B. K., 2013, In : Free Radical Biology and Medicine. 60, p. 264 - 271 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Nitroxyl donors retain their depressor effects in hypertension

Irvine, J. C., Ravi, R. M., Harper, B. K. & Widdop, R. E., 2013, In : American Journal of Physiology - Heart and Circulatory Physiology. 305, 6, p. 939 - 945 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Nox1 oxidase suppresses influenza a virus-induced lung inflammation and oxidative stress

Selemidis, S., Seow, H. J., Broughton, B. R. S., Vinh, A., Bozinovski, S., Sobey, C. G., Drummond, G. R. & Vlahos, R., 2013, In : PLoS ONE. 8, 4, 12 p., e60792.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File

Obesity-related hypertension and the role of insulin and leptin in high-fat-fed rabbits

Lim, K. J., Burke, S. L. & Head, G. A., 2013, In : Hypertension. 61, 3, p. 628 - 634 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Obesity results in progressive atrial structural and electrical remodeling: implications for atrial fibrillation

Abed, H. S., Samuel, C. S., Lau, D. H., Kelly, D. J., Royce, S. G., Alasady, M., Mahajan, R., Kuklik, P., Zhang, Y. M., Brooks, A. G., Nelson, A. J., Worthley, S. G., Abhayaratna, W., Kalman, J., Wittert, G. G. & Sanders, P., 2013, In : Heart Rhythm. 10, 1, p. 90 - 100 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Orthosteric binding of rho-Da1a, a natural peptide of snake venom interacting selectively with the alpha(1A)-Adrenoceptor

Maiga, A., Merlin, J., Marcon, E., Rouget, C., Larregola, M., Gilquin, B., Fruchart-Gaillard, C., Lajeunesse, E., Marchetti, C., Lorphelin, A., Bellanger, L., Summers, R. J., Hutchinson, D. S., Evans, B. A., Servent, D. & Gilles, N., 2013, In : PLoS ONE. 8, 7, 11 p., e68841.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File

Pathogenesis of acute stroke and the role of inflammasomes

Fann, D. Y-W., Lee, S-Y., Manzanero, S., Chunduri, P., Sobey, C. G. & Arumugam, T., 2013, In : Ageing Research Reviews. 12, 4, p. 941 - 966 26 p.

Research output: Contribution to journalArticleResearchpeer-review

Phenotyping dividing cells in mouse models of neurodegenerative basal ganglia diseases

Smardencas, A., Rizkalla, K., Kim, H. A., Massalas, J. S., O'Leary, C., Ehrlich, M. E., Schutz, G., Lawrence, A. J. & Drago, J., 2013, In : BMC Neuroscience. 14, Art. No.: 111, p. 1 - 19 19 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Polar transmembrane interactions drive formation of ligand-specific and signal pathway-biased family B G protein-coupled receptor conformations

Wootten, D. L., Simms, J. W., Miller, L. J., Christopoulos, A. & Sexton, P., 2013, In : Proceedings of the National Academy of Sciences. 110, 13, p. 5211 - 5216 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Population divergence in venom bioactivities of elapid snake Pseudonaja textilis: role of procoagulant proteins in rapid rodent prey incapacitation

Skejic, J. & Hodgson, W. C., 2013, In : PLoS ONE. 8, 5 (Art. ID: e63988), p. 1 - 10 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
Open Access

Probing structural requirements of positive allosteric modulators of the M4 muscarinic receptor

Huynh, T., Valant, C., Crosby, I. T., Sexton, P., Christopoulos, A. & Capuano, B., 2013, In : Journal of Medicinal Chemistry. 56, 20, p. 8196 - 8200 5 p.

Research output: Contribution to journalArticleResearchpeer-review

Protective arms of the renin-angiotensin-system in neurological disease

Sumners, C., Horiuchi, M., Widdop, R. E., McCarthy, C. A., Unger, T. & Steckelings, U. M., 2013, In : Clinical and Experimental Pharmacology and Physiology. 40, 8, p. 580 - 588 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Recent advances in understanding GLP-1R (glucagon-like peptide-1 receptor) function

Koole, C. R., Pabreja, K., Savage, E. E., Wootten, D. L., Furness, S. G. B., Miller, L. J., Christopoulos, A. & Sexton, P., 2013, In : Biochemical Society Transactions. 41, 1, p. 172 - 179 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Reduced preprandial dipping accounts for rapid elevation of blood pressure and renal sympathetic nerve activity in rabbits fed a high-fat diet

Burke, S. L., Prior, L. J., Lukoshkova, E. V., Lim, K., Barzel, B., Davern, P. J., Armitage, J. & Head, G. A., 2013, In : Chronobiology International. 30, 5, p. 726 - 738 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Regulation of G protein-coupled receptors by allosteric ligands

Lane, J. R. D., Abdul Ridha, A. & Canals, M., 2013, In : ACS Chemical Neuroscience. 4, 4, p. 527 - 534 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Relaxin and its role in fibrotic diseases

Chan, L. J., Samuel, C. S., Separovic, F., Hossain, M. A. & Wade, J. D., 2013, Amino Acids, Peptides and Proteins. Farkas, E. & Ryadnov, M. (eds.). 1st ed. UK: RSC Publishing, p. 60 - 78 19 p.

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Researchpeer-review

Relaxin family peptides and their receptors

Bathgate, R., Halls, M. L., van der Westhuizen, E. T., Callander, G., Kocan, M. & Summers, R. J., 2013, In : Physiological Reviews. 93, 1, p. 405 - 480 76 p.

Research output: Contribution to journalArticleResearchpeer-review

Signalling bias in new drug discovery: detection, quantification and therapeutic impact

Kenakin, T. & Christopoulos, A., 2013, In : Nature Reviews Drug Discovery. 12, 3, p. 205 - 216 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Species differences in the neuromuscular activity of post-synaptic neurotoxins from two Australian black snakes (Pseudechis porphyriacus and Pseudechis colletti)

Hart, A. J., Isbister, G. K., O'Donnell, P., Williamson, N. A. & Hodgson, W. C., 2013, In : Toxicology Letters. 219, 3, p. 262 - 268 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Stroke increases g protein-coupled estrogen receptor expression in the brain of male but not female mice

Broughton, B. RS., Brait, V. H., Guida, E., Lee, S., Arumugam, T. V., Gardiner-Mann, C. V., Miller, A. A., Tang, S-C., Drummond, G. R. & Sobey, C. G., 2013, In : Neurosignals. 21, 3-4, p. 229 - 239 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Structural basis for modulation of a G-protein-coupled receptor by allosteric drugs

Dror, R., Green, H. F., Valant, C., Borhani, D. W., Valcourt, J. R., Pan, A. C., Arlow, D. H., Canals, M., Lane, J. R. D., Rahmani, R. S., Baell, J. B., Sexton, P., Christopoulos, A. & Shaw, D. E., 2013, In : Nature. 503, 7475, p. 295 - 299 5 p.

Research output: Contribution to journalArticleResearchpeer-review

Structural biology: meet the B family

Sexton, P. & Wootten, D. L., 2013, In : Nature. 499, 7459, p. 417 - 418 2 p.

Research output: Contribution to journalLetterOther

Supra-physiological efficacy at GPCRs: superstition or super agonists?

Langmead, C. J. & Christopoulos, A., 2013, In : British Journal of Pharmacology. 169, 2, p. 353 - 356 4 p.

Research output: Contribution to journalArticleOtherpeer-review

The anti-fibrotic hormone relaxin is not reno-protective, despite being active, in an experimental model of type 1 diabetes

Wong, S. E., Samuel, C. S., Kelly, D. J., Zhang, Y., Becker, G. & Hewitson, T. D., 2013, In : Protein and Peptide Letters. 20, 9, p. 1029 - 1038 10 p.

Research output: Contribution to journalArticleResearchpeer-review

The apelin receptor inhibits the angiotensin II type 1 receptor via allosteric trans-inhibition

Siddiquee, K., Hampton, J., McAnally, D., May, L. T. & Smith, L. H., 2013, In : British Journal of Pharmacology. 168, 5, p. 1104 - 1117 14 p.

Research output: Contribution to journalArticleResearchpeer-review

The nitric oxide redox sibling nitroxyl partially circumvents impairment of platelet nitric oxide responsiveness

Dautov, R., Ngo, D., Licari, G., Liu, S., Sverdlov, A. L., Ritchie, R. H., Harper, B. K., Horowitz, J. D. & Chirkov, Y. Y., 2013, In : Nitric Oxide-Biology and Chemistry. 35, p. 72 - 78 7 p.

Research output: Contribution to journalArticleResearchpeer-review

The role of ghrelin in neuroprotection after ischemic brain injury

Spencer, S. J., Miller, A. A. & Andrews, Z. B., 1 Jan 2013, In : Brain Sciences. 3, 1, p. 344-359 16 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

Tiger snake (Notechis spp) envenoming: Australian Snakebite Project (ASP-13).

Isbister, G. K., Buckley, N. A. & Brown, S. G., 4 Mar 2013, In : Medical Journal of Australia. 198, 4, p. 194-195 2 p.

Research output: Contribution to journalComment / DebateOtherpeer-review

Trefoil factor-2 reverses airway remodeling changes in allergic airways disease

Royce, S. G., Lim, C., Muljadi, R. C. M., Samuel, C. S., Ververis, K., Karagiannis, T. C., Giraud, A. S. & Tang, M. LK., 2013, In : American Journal of Respiratory Cell and Molecular Biology. 48, 1, p. 135 - 144 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Update on the angiotensin AT(2) receptor

McCarthy, C. A., Widdop, R. E., Denton, K. M. & Jones, E. S., 2013, In : Current Hypertension Reports. 15, 1, p. 25 - 30 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Venom proteomic characterization and relative antivenom neutralization of two medically important Pakistani elapid snakes (Bungarus sindanus and Naja naja)

Ali, S. A., Yang, D., Jackson, T. N. W., Undheim, E. A. B., Koludarov, I., Wood, K., Jones, A., Hodgson, W. C., McCarthy, S., Ruder, T. & Fry, B. G., 2013, In : Journal of Proteomics. 89, p. 15 - 23 9 p.

Research output: Contribution to journalArticleResearchpeer-review

2012

Adiponectin receptor signalling in the brain

Thundyil, J., Pavlovski, D., Sobey, C. & Arumugam, T., 2012, In : British Journal of Pharmacology. 165, 2, p. 313 - 327 15 p.

Research output: Contribution to journalArticleResearchpeer-review

Aldosterone and the mineralocorticoid receptor in the cerebral circulation and stroke

Dinh, Q. N., Arumugam, T. V., Young, M. J., Drummond, G. R., Sobey, C. G. & Chrissobolis, S., 2012, In : Experimental & Translational Stroke Medicine. 4, 1 (Art. No.: 21), p. 1 - 21 21 p.

Research output: Contribution to journalArticleResearchpeer-review

Allosteric modulation of endogenous metabolites as an avenue for drug discovery

Wootten, D. L., Savage, E. E., Valant, C., May, L. T., Sloop, K. W., Ficorilli, J., Showalter, A. D., Willard, F. S., Christopoulos, A. & Sexton, P. M., 2012, In : Molecular Pharmacology. 82, 2, p. 281 - 290 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Allosteric modulation of seven transmembrane spanning receptors: theory, practice, and opportunities for central nervous system drug discovery

Melancon, B. J., Hopkins, C. R., Wood, M. R., Emmitte, K. A., Niswender, C. M., Christopoulos, A., Conn, P. J. & Lindsley, C. W., 2012, In : Journal of Medicinal Chemistry. 55, 4, p. 1445 - 1464 20 p.

Research output: Contribution to journalArticleResearchpeer-review

A Monod-Wyman-Changeux mechanism can explain G protein-coupled receptor (GPCR) allosteric modulation

Canals, M., Lane, J., Wen, A., Scammells, P., Sexton, P. & Christopoulos, A., 2012, In : Journal of Biological Chemistry. 287, 1, p. 650 - 659 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Angiotensin II receptors and neuroprotection

Widdop, R. E., Steckelings, U. M., McCarthy, C. & Callaway, J. K., 1 Jan 2012, Neuropeptides in Neuroprotection and Neuroregeneration. Nyberg, F. J. (ed.). 1 ed. Boca Raton FL USA: CRC Press, p. 165-178 14 p.

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Researchpeer-review

Angiotensin II Type 2 receptor stimulation initiated after stroke causes neuroprotection in conscious rats

McCarthy, C. A., Vinh, A., Broughton, B. RS., Sobey, C. G., Callaway, J. K. & Widdop, R. E., 2012, In : Hypertension. 60, 6, p. 1531 - 1537 7 p.

Research output: Contribution to journalArticleResearchpeer-review

A simple method for quantifying functional selectivity and agonist bias

Kenakin, T., Watson, C., Muniz-Medina, V., Christopoulos, A. & Novick, S., 2012, In : ACS Chemical Neuroscience. 3, 3, p. 193 - 203 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Beta(2)-adrenoceptors increase translocation of GLUT4 via GPCR kinase sites in the receptor C-terminal tail

Dehvari, N., Hutchinson, D., Nevzorova, J., Dallner, O., Sato, M., Kocan, M., Merlin, J., Evans, B., Summers, R. & Bengtsson, T., 2012, In : British Journal of Pharmacology. 165, 5, p. 1442 - 1456 15 p.

Research output: Contribution to journalArticleResearchpeer-review