Research Output 1986 2019

2014

Unexpected anti-hypertrophic responses to low-level stimulation of protease-activated receptors in adult rat cardiomyocytes

Fender, A. C., Pavic, G., Drummond, G. R., Dusting, G. J. & Ritchie, R. H., 2014, In : Naunyn-Schmiedeberg's Archives of Pharmacology. 387, 10, p. 1001 - 1007 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Vasoactive role for angiotensin II type 2 receptors in human radial artery

Zulli, A., Hare, D. L., Buxton, B. F. & Widdop, R. E., 2014, In : International Journal of Immunopathology and Pharmacology. 27, 1, p. 79 - 85 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Vintage venoms: proteomic and pharmacological stability of snake venoms stored for up to eight decades

Jesupret, C., Baumann, K., Jackson, T. N. W., Ali, S. A., Yang, D., Greisman, L., Kern, L., Steuten, J. A., Jouiaei, M., Casewell, N. R., Undheim, E. A. B., Koludarov, I., Debono, J., Low, D. H. W., Rossi, S., Panagides, N., Winter, K. L., Ignjatovic, V., Summerhayes, R., Jones, A. & 6 othersNouwens, A. S., Dunstan, N., Hodgson, W. C., Winkel, K., Monagle, P. & Fry, B., 2014, In : Journal of Proteomics. 105, p. 285 - 294 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Accumulation of serum lipids by vascular smooth muscle cells involves a macropinocytosis-like uptake pathway and is associated with the downregulation of the ATP-binding cassette transporter A1

Rivera, J., Walduck, A., Thomas, S. R., Glaros, E. N., Hooker, E. U., Guida, E., Sobey, C. G. & Drummond, G. R., 2013, In : Naunyn-Schmiedeberg's Archives of Pharmacology. 386, 12, p. 1081 - 1093 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Activation and allosteric modulation of a muscarinic acetylcholine receptor

Kruse, A. C., Ring, A. M., Manglik, A., Hu, J., Hu, K., Eitel, K., Hubner, H., Pardon, E., Valant, C., Sexton, P., Christopoulos, A., Felder, C. C., Gmeiner, P., Steyaert, J., Weis, W., Garcia, K. C., Wess, J. & Kobilka, B., 2013, In : Nature. 504, 7478, p. 101 - 106 6 p.

Research output: Contribution to journalArticleResearchpeer-review

A flow cytometric method for the analysis of macrophages in the vascular wall

Moore, J., Sakkal, S., Bullen, M. L., Harper, B. K., Ricardo, S. D., Sobey, C. G. & Drummond, G. R., 2013, In : Journal of Immunological Methods. 396, 1-2, p. 33 - 43 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Allosteric approaches to GPCR drug discovery

Lane, J. R. & Ijzerman, A. P., 2013, In : Drug Discovery Today: Technologies. 10, 2

Research output: Contribution to journalEditorialOtherpeer-review

Allosteric modulation of a chemogenetically modified G protein-coupled receptor

Abdul Ridha, A., Lane, J. R. D., Sexton, P., Canals, M. & Christopoulos, A., 2013, In : Molecular Pharmacology. 83, 2, p. 521 - 530 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Alpha neurotoxins

Barber, C. M., Isbister, G. K. & Hodgson, W. C., 2013, In : Toxicon : official journal of the International Society on Toxinology. 66, p. 47 - 58 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Amine oxidase activity of beta-amyloid precursor protein modulates systemic and local catecholamine levels

Duce, J. A., Ayton, S., Miller, A. A., Tsatsanis, A., Lam, L. Q., Leone, L., Corbin, J. E., Butzkueven, H., Kilpatrick, T., Rogers, J. T., Barnham, K. J., Finkelstein, D. I. & Bush, A. I., 2013, In : Molecular Psychiatry. 18, 2, p. 245 - 254 10 p.

Research output: Contribution to journalArticleResearchpeer-review

An assessment of the in vivo effects of intravenous lipid emulsion on blood drug concentration and haemodynamics following oro-gastric amitriptyline overdose

Perichon, D., Turfus, S. C., Gerostamoulos, D. & Graudins, A., 2013, In : Clinical Toxicology. 51, 4, p. 208 - 215 8 p.

Research output: Contribution to journalArticleResearchpeer-review

An evaluation of pharmacology curricula in Australian science and health-related degree programs

Lloyd, H. GE., Hinton, T., Bullock, S. P., Babey, A-M., Davis, E. A., Fernandes, L., Hart, J., Musgrave, I. & Ziogas, J., 2013, In : BMC Medical Education. 13, Art. No.:153, p. 1 - 15 15 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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An examination of cardiovascular collapse induced by eastern brown snake (Pseudonaja textilis) venom

Chaisakul, J., Isbister, G. K., Kuruppu, D. M. S., Konstantakopoulos, N. & Hodgson, W. C., 2013, In : Toxicology Letters. 221, 3, p. 205 - 211 7 p.

Research output: Contribution to journalArticleResearchpeer-review

A Novel Interaction Between Sympathetic Overactivity and Aberrant Regulation of Renin by miR-181a in BPH/2J Genetically Hypertensive Mice

Jackson, K. L., Marques, F. Z., Watson, A., Palma-Rigo, K., Nguyen-Huu, T-P., Morris, B. J., Charchar, F., Davern, P. J. & Head, G. A., 2013, In : Hypertension. 62, 4, p. 775 - 781 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Anti-inflammatory effects of adult stem cells in sustained lung injury: a comparative study

Moodley, Y., Vaghjiani, V., Chan, M. K. J., Baltic, S., Ryan, M., Tchongue, J., Samuel, C. S., Murthi, P., Parolini, O. & Manuelpillai, U. C., 2013, In : PLoS ONE. 8, 8 (Art. No.: e69299), p. 1 - 9 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

A simple method to generate stable cell lines for the analysis of transient protein-protein interactions

Savage, E. E., Wootten, D. L., Christopoulos, A., Sexton, P. & Furness, S. G. B., 2013, In : BioTechniques. 54, 4, p. 217 - 221 5 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File

A structure-activity analysis of biased agonism at the dopamine D2 receptor

Shonberg, J., Klein Herenbrink, C., Lopez, L., Christopoulos, A., Scammells, P. J., Capuano, B. & Lane, J. R. D., 2013, In : Journal of Medicinal Chemistry. 56, 22, p. 9199 - 9221 23 p.

Research output: Contribution to journalArticleResearchpeer-review

Bridging the gap: bitopic ligands of G-protein-coupled receptors

Lane, J. R. D., Sexton, P. M. & Christopoulos, A., 2013, In : Trends in Pharmacological Sciences. 34, 1, p. 59 - 66 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Calcium-sensing receptor-dependent activation of CREB phosphorylation in HEK293 cells and human parathyroid cells

Avlani, V. A., Ma, W., Mun, H., Leach, K., Delbridge, L., Christopoulos, A. & Conigrave, A., 2013, In : American Journal of Physiology - Endocrinology and Metabolism. 304, 10, p. 1097 - 1104 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Calsenilin contributes to neuronal cell death in ischemic stroke

Park, J-S., Manzanero, S., Chang, J-W., Choi, Y., Baik, S-H., Cheng, Y-L., Li, Y., Gwon, A-R., Woo, H-N., Jang, J., Choi, I-Y., Lee, J-Y., Jung, Y-K., Tang, S-C., Sobey, C. G., Arumugam, T. & Jo, D-G., 2013, In : Brain Pathology. 23, 4, p. 402 - 412 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Cardiovascular role of angiotensin type1A receptors in the nucleus of the solitary tract of mice

Abegaz, B., Davern, P. J., Jackson, K. L., Nguyen-Huu, T-P., Bassi, J. K., Connelly, A., Choong, Y-T., Allen, A. M. & Head, G. A., 2013, In : Cardiovascular Research. 100, 2, p. 181 - 191 11 p.

Research output: Contribution to journalArticleResearchpeer-review

CEACAM1: an adhesion molecule that limits blood-brain barrier damage by neutrophils after stroke

Sobey, C. G. & Drummond, G. R., 2013, In : Circulation Research. 113, 8, p. 952 - 953 2 p.

Research output: Contribution to journalLetterOther

CGRP/adrenomedullin

Wootten, D. L., Tilakaratne, N., Christopoulos, A. & Sexton, P., 2013, Handbook of Biologically Active Peptides. Kastin, A. J. (ed.). Second Edition ed. San Diego CA USA: Elsevier, p. 744 - 751 8 p.

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Researchpeer-review

Chronic activation of the low affinity site of beta -adrenoceptors stimulates haemodynamics but exacerbated pressure-overload cardiac remodelling

Kiriazis, H., Tugiono, N., Xu, Q., Gao, X-M., Jennings, N., Ming, Z., Su, Y., Klenowski, P., Summers, R. J., Kaumann, A., Molenaar, P. & Du, X-J., 2013, In : British Journal of Pharmacology. 170, 2, p. 352 - 365 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Chronic NaHS treatment is vasoprotective in high-fat-fed ApoE-/- mice

Ford, A., Al-Magableh, M. R., Gaspari, T. A. & Hart, J. L., 2013, In : International Journal of Vascular Medicine. 2013, Art # 915983, p. 1 - 8 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Comment on "protective arms of the renin-angiotensin system in neurological disease": Reply

Sumners, C., Horiuchi, M., Widdop, R. E., Mccarthy, C., Unger, T. & Steckelings, U. M., Nov 2013, In : Clinical and Experimental Pharmacology and Physiology. 40, 11, p. 838-839 2 p.

Research output: Contribution to journalLetterOtherpeer-review

Cross-neutralisation of the neurotoxic effects of Egyptian cobra venom with commercial tiger snake antivenom

Kornhauser, R. S., Isbister, G. K., O'Leary, M. A., Mirtschin, P., Dunstan, N. & Hodgson, W. C., 2013, In : Basic and Clinical Pharmacology and Toxicology. 112, 2, p. 138 - 143 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Development of human cells with RXFP1 knockdown using retroviral delivery of microRNA against human RXFP1

Yong, K. J., Callander, G. E., Bergin, R., Samuel, C. S. & Bathgate, R. A. D., 2013, In : Italian Journal of Anatomy and Embryology. 118, 1 SUPPL., p. 10-12 3 p.

Research output: Contribution to journalArticleOtherpeer-review

Development of M1 mAChR allosteric and bitopic ligands: Prospective therapeutics for the treatment of cognitive deficits

Davie, B. J., Christopoulos, A. & Scammells, P. J., 2013, In : ACS Chemical Neuroscience. 4, 7, p. 1026 - 1048 23 p.

Research output: Contribution to journalArticleResearchpeer-review

Differential activation and modulation of the glucagon-like peptide-1 receptor by small molecule ligands

Wootten, D. L., Savage, E. E., Willard, F. S., Bueno, A. B., Sloop, K. W., Christopoulos, A. & Sexton, P., 2013, In : Molecular Pharmacology. 83, 4, p. 822 - 834 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Differential evolution and neofunctionalization of snake venom metalloprotease domains

Brust, A., Sunagar, K., Undheim, E. A. B., Vetter, I., Yang, D., Casewell, N. R., Jackson, T. N. W., Koludarov, I., Alewood, P. F., Hodgson, W. C., Lewis, R. J., King, G. F., Antunes, A., Hendrikx, I. & Fry, B. G., 2013, In : Molecular & Cellular Proteomics. 12, 3, p. 651 - 663 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Direct AT{2} receptor stimulation is athero-protective and stabilizes plaque in Apolipoprotein E-deficient mice

Tesanovic Kljajic, S., Widdop, R. E., Vinh, A., Welungoda, I. K., Bosnyak, S., Jones, E. S. & Gaspari, T. A., 2013, In : International Journal of Cardiology. 169, 4, p. 281 - 287 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Does a nephron deficit exacerbate the renal and cardiovascular effects of obesity?

Gurusinghe, S., Brown, R. D., Cai, X., Samuel, C. S., Ricardo, S. D., Thomas, M. C. & Kett, M. M., 2013, In : PLoS ONE. 8, 9, 8 p., e73095.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File

Emerging paradigms in GPCR allostery: implications for drug discovery

Wootten, D. L., Christopoulos, A. & Sexton, P., 2013, In : Nature Reviews Drug Discovery. 12, 8, p. 630 - 644 15 p.

Research output: Contribution to journalArticleResearchpeer-review

Endogenous ghrelin's role in hippocampal neuroprotection after global cerebral ischemia: does endogenous ghrelin protect against global stroke?

Kenny, R., Cai, G., Bayliss, J., Clarke, M., Choo, Y. L., Miller, A. A., Andrews, Z. B. & Spencer, S., 2013, In : American Journal of Physiology - Regulatory Integrative and Comparative Physiology. 304, 11, p. 980 - 990 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Endothelial dysfunction in patients with type 2 diabetes post acute coronary syndrome

Lumsden, N. G., Andrews, K. L., Bobadilla, M., Moore, X. L., Sampson, A. K., Shaw, J. A., Mizrahi, J., Kaye, D. M., Dart, A. M. & Chin-Dusting, J. P. F., Jul 2013, In : Diabetes and Vascular Disease Research. 10, 4, p. 368-374 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Enhanced depolarization-induced pulmonary vasoconstriction following chronic hypoxia requires EGFR-dependent activation of NAD(P)H oxidase 2

Norton, C. E., Broughton, B. RS., Jernigan, N. L., Walker, B. R. & Resta, T. C., 2013, In : Antioxidants and Redox Signaling. 18, 14, p. 1777 - 1788 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Erratum: Differential activation and modulation of the glucagon-like peptide-1 receptor by small molecular ligands (Molecular Pharmacology (2013) 83 (822-834))

Wootten, D., Savage, E. E., Willard, F. S., Bueno, A. B., Sloop, K. W., Christopoulos, A. & Sexton, P. M., Jul 2013, In : Molecular Pharmacology. 84, 1, p. 170 1 p.

Research output: Contribution to journalComment / DebateOtherpeer-review

Erratum - Differential evolution and neofunctionalization of snake venom metalloprotease domains (Molecular and Cellular Proteomics 2013, 12, (651-663))

Brust, A., Sunagar, K., Undheim, E. A. B., Vetter, I., Yang, D. C., Casewell, N. R., Jackson, T. N. W., Koludarov, I., Alewood, P. F., Hodgson, W. C., Lewis, R. J., King, G. F., Antunes, A., Hendrikx, I. & Fry, B. G., May 2013, In : Molecular & Cellular Proteomics. 12, 5, p. 1488 1 p.

Research output: Contribution to journalComment / DebateOtherpeer-review

Evidence for a detrimental role of TLR8 in ischemic stroke

Tang, S-C., Yeh, S-J., Li, Y., Wang, Y-C. W., Baik, S-H., Santro, T., Widiapradja, A., Manzanero, S., Sobey, C. G., Jo, D-G., Arumugam, T. & Jeng, J-S., 2013, In : Experimental Neurology. 250, p. 341 - 347 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Evidence that the EphA2 receptor exacerbates ischemic brain injury

Thundyil, J., Manzanero, S., Pavlovski, D., Cully, T. R., Lok, K-Z., Widiapradja, A., Chunduri, P., Jo, D-G., Asano, M., Launikonis, B. S., Sobey, C. G., Coulthard, M. G. & Arumugam, T., 2013, In : PLoS ONE. 8, 1, 8 p., e53528.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Glutathione peroxidase-1 reduces influenza A virus-induced lung inflammation

Yatmaz, S., Seow, H. J., Gualano, R. C., Wong, Z. X., Stambas, J., Selemidis, S., Crack, P. J., Bozinovski, S., Anderson, G. & Vlahos, R., 2013, In : American Journal of Respiratory Cell and Molecular Biology. 48, 1, p. 17 - 26 10 p.

Research output: Contribution to journalArticleResearchpeer-review

HNO/cGMP-dependent antihypertrophic actions of isopropylamine-NONOate in neonatal rat cardiomyocytes: potential therapeutic advantages of HNO over NO

Irvine, J. C., Cao, N., Gossain, S., Alexander, A. E., Love, J. E., Qin, C., Horowitz, J. D., Harper, B. K. & Ritchie, R. H., 2013, In : American Journal of Physiology - Heart and Circulatory Physiology. 305, 3, p. 365 - 377 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Impact of chronic congestive heart failure on pharmacokinetics and vasomotor effects of infused nitrite

Maher, A. R., Arif, S., Madhani, M., Abozguia, K., Ahmed, I., Fernandez, B. O., Feelisch, M., O'Sullivan, A. G., Christopoulos, A., Sverdlov, A. L., Ngo, D., Dautov, R., James, P. E., Horowitz, J. D. & Frenneaux, M. P., 2013, In : British Journal of Pharmacology. 169, 3, p. 659 - 670 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Impact of clinically relevant mutations on the pharmacoregulation and signaling bias of the calcium-sensing receptor by positive and negative allosteric modulators

Leach, K., Wen, C., Cook, A. E., Sexton, P., Conigrave, A. & Christopoulos, A., 2013, In : Endocrinology. 154, 3, p. 1105 - 1116 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Inhibition of tumor angiogenesis and growth by a small-molecule multi-FGF receptor blocker with allosteric properties

Bono, F., De Smet, F., Herbert, C., De Bock, K., Georgiadou, M., Fons, P., Tjwa, M., Alcouffe, C., Ny, A., Bianciotto, M., Jonckx, B., Murakami, M., Lanahan, A. A., Michielsen, C., Sibrac, D., Dol-Gleizes, F., Mazzone, M., Zacchigna, S., Herault, J-P., Fischer, C. & 33 othersRigon, P., Ruiz de Almodovar, C., Claes, F., Blanc, I., Poesen, K., Zhang, Z., Segura, I., Gueguen, G., Bordes, M-F., Lambrechts, D., Broussy, R., van de Wouwer, M., Michaux, C., Shimada, T., Jean, I., Blacher, S., Noel, A., Motte, P., Rom, E., Rakic, J-M., Katsuma, S., Schaeffer, P., Yayon, A., Van Schepdael, A., Schwalbe, H., Gervasio, F. L., Carmeliet, G., Rozensky, J., Dewerchin, M., Simons, M., Christopoulos, A., Herbert, J-M. & Carmeliet, P., 2013, In : Cancer Cell. 23, 4, p. 477 - 488 12 p.

Research output: Contribution to journalArticleResearchpeer-review