Research Output 1986 2019

2014

Short term fat feeding rapidly increases plasma insulin but does not result in dyslipidaemi

Barzel, B., Weir, J. M., Meikle, P. J., Burke, S. L., Armitage, J. & Head, G. A., 2014, In : Frontiers in Physiology. 5, (Art. No: 469), p. 1 - 8 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Signalling profiles of H3 relaxin, H2 relaxin and R3(B?23-27)R/I5 acting at the relaxin family peptide receptor 3 (RXFP3)

Kocan, M., Sarwar, M., Hossain, M. A., Wade, J. D. & Summers, R. J., 2014, In : British Journal of Pharmacology. 171, 11, p. 2827 - 2841 15 p.

Research output: Contribution to journalArticleResearchpeer-review

Structural and functional insights into the juxtamembranous amino-terminal tail and extracellular loop regions of class B GPCRs

Dong, M., Koole, C. R., Wootten, D. L., Sexton, P. & Miller, L. J., 2014, In : British Journal of Pharmacology. 171, 5, p. 1085 - 1101 17 p.

Research output: Contribution to journalArticleResearchpeer-review

Structure-activity relationships of privileged structures lead to the discovery of novel biased ligands at the dopamine D2 receptor

Szabo, M., Klein Herenbrink, C., Christopoulos, A., Lane, J. R. D. & Capuano, B., 2014, In : Journal of Medicinal Chemistry. 57, 11, p. 4924 - 4939 16 p.

Research output: Contribution to journalArticleResearchpeer-review

Tachykinins and their receptors: Contributions to physiological control and the mechanisms of disease

Steinhoff, M. S., von Mentzer, B., Geppetti, P., Pothoulakis, C. & Bunnett, N. W., 2014, In : Physiological Reviews. 94, 1, p. 265 - 301 37 p.

Research output: Contribution to journalArticleResearchpeer-review

The bile acid receptor TGR5 activates the TRPA1 channel to induce itch in mice

Lieu, T. M., Jayaweera, G., Zhao, P., Poole, D. P., Jensen, D. D., Grace, M., McIntyre, P., Bron, R., Wilson, Y., Krappitz, M., Haerteis, S., Korbmacher, C., Steinhoff, M. S., Nassini, R., Materazzi, S., Geppetti, P., Corvera, C. U. & Bunnett, N. W., 2014, In : Gastroenterology. 147, 6, p. 1417 - 1428 12 p.

Research output: Contribution to journalArticleResearchpeer-review

The class B G-protein-coupled GLP-1 receptor: an important target for the treatment of type-2 diabetes mellitus

Miller, L. J., Sexton, P. M., Dong, M. & Harikumar, K. G., 2014, In : International Journal of Obesity. 4, p. S9-S13 5 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

The effect of gas exchange on multiple-breath nitrogen washout measures of ventilation inhomogeneity in the mouse

Dharmakumara, M., Prisk, G. K., Royce, S. G., Tawhai, M. & Thompson, B. R., 2014, In : Journal of Applied Physiology. 117, 9, p. 1049 - 1054 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Themed issue of the British Journal of Pharmacology

Summers, R. J., 2014, In : British Journal of Pharmacology. 171, 5, p. 1069 - 1072 4 p.

Research output: Contribution to journalLetterOther

The protective arms of the renin-angiontensin system in stroke

McCarthy, C. A., Facey, L. J. & Widdop, R. E., 2014, In : Current Hypertension Reports. 16, 7 (Art. No: 440), p. 1 - 8 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Therapeutic effects of serelaxin in acute heart failure

Du, X-J., Hewitson, T. D., Nguyen, M-N. & Samuel, C. S., 2014, In : Circulation Journal. 78, 3, p. 542 - 552 11 p.

Research output: Contribution to journalArticleResearchpeer-review

The tyrosine kinase inhibitor bafetinib inhibits PAR2-induced activation of TRPV4 channels in vitro and pain in vivo

Grace, M., Lieu, T. M., Darby, B., Abogadie, F. C., Veldhuis, N. A., Bunnett, N. W. & McIntyre, P., 2014, In : British Journal of Pharmacology. 171, 16, p. 3881 - 3894 14 p.

Research output: Contribution to journalArticleResearchpeer-review

TLR2 activation causes tachyphylaxis to β2-Agonists in vitro and ex vivo: Modelling bacterial exacerbation

Alkhouri, H., Rumzhum, N. N., Rahman, M. M., Fitzpatrick, M., De Pedro, M., Oliver, B. G., Bourke, J. E. & Ammit, A. J., Sep 2014, In : Allergy. 69, 9, p. 1215-1222 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Understanding the biology of reactive oxygen species and their link to cancer: NADPH oxidases as novel pharmacological targets

Harrison, I. & Selemidis, S., 2014, In : Clinical and Experimental Pharmacology and Physiology. 41, 8, p. 533 - 542 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Unexpected anti-hypertrophic responses to low-level stimulation of protease-activated receptors in adult rat cardiomyocytes

Fender, A. C., Pavic, G., Drummond, G. R., Dusting, G. J. & Ritchie, R. H., 2014, In : Naunyn-Schmiedeberg's Archives of Pharmacology. 387, 10, p. 1001 - 1007 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Vasoactive role for angiotensin II type 2 receptors in human radial artery

Zulli, A., Hare, D. L., Buxton, B. F. & Widdop, R. E., 2014, In : International Journal of Immunopathology and Pharmacology. 27, 1, p. 79 - 85 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Vintage venoms: proteomic and pharmacological stability of snake venoms stored for up to eight decades

Jesupret, C., Baumann, K., Jackson, T. N. W., Ali, S. A., Yang, D., Greisman, L., Kern, L., Steuten, J. A., Jouiaei, M., Casewell, N. R., Undheim, E. A. B., Koludarov, I., Debono, J., Low, D. H. W., Rossi, S., Panagides, N., Winter, K. L., Ignjatovic, V., Summerhayes, R., Jones, A. & 6 others, Nouwens, A. S., Dunstan, N., Hodgson, W. C., Winkel, K., Monagle, P. & Fry, B., 2014, In : Journal of Proteomics. 105, p. 285 - 294 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Accumulation of serum lipids by vascular smooth muscle cells involves a macropinocytosis-like uptake pathway and is associated with the downregulation of the ATP-binding cassette transporter A1

Rivera, J., Walduck, A., Thomas, S. R., Glaros, E. N., Hooker, E. U., Guida, E., Sobey, C. G. & Drummond, G. R., 2013, In : Naunyn-Schmiedeberg's Archives of Pharmacology. 386, 12, p. 1081 - 1093 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Activation and allosteric modulation of a muscarinic acetylcholine receptor

Kruse, A. C., Ring, A. M., Manglik, A., Hu, J., Hu, K., Eitel, K., Hubner, H., Pardon, E., Valant, C., Sexton, P., Christopoulos, A., Felder, C. C., Gmeiner, P., Steyaert, J., Weis, W., Garcia, K. C., Wess, J. & Kobilka, B., 2013, In : Nature. 504, 7478, p. 101 - 106 6 p.

Research output: Contribution to journalArticleResearchpeer-review

A flow cytometric method for the analysis of macrophages in the vascular wall

Moore, J., Sakkal, S., Bullen, M. L., Harper, B. K., Ricardo, S. D., Sobey, C. G. & Drummond, G. R., 2013, In : Journal of Immunological Methods. 396, 1-2, p. 33 - 43 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Allosteric approaches to GPCR drug discovery

Lane, J. R. & Ijzerman, A. P., 2013, In : Drug Discovery Today: Technologies. 10, 2

Research output: Contribution to journalEditorialOtherpeer-review

Allosteric modulation of a chemogenetically modified G protein-coupled receptor

Abdul Ridha, A., Lane, J. R. D., Sexton, P., Canals, M. & Christopoulos, A., 2013, In : Molecular Pharmacology. 83, 2, p. 521 - 530 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Alpha neurotoxins

Barber, C. M., Isbister, G. K. & Hodgson, W. C., 2013, In : Toxicon : official journal of the International Society on Toxinology. 66, p. 47 - 58 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Amine oxidase activity of beta-amyloid precursor protein modulates systemic and local catecholamine levels

Duce, J. A., Ayton, S., Miller, A. A., Tsatsanis, A., Lam, L. Q., Leone, L., Corbin, J. E., Butzkueven, H., Kilpatrick, T., Rogers, J. T., Barnham, K. J., Finkelstein, D. I. & Bush, A. I., 2013, In : Molecular Psychiatry. 18, 2, p. 245 - 254 10 p.

Research output: Contribution to journalArticleResearchpeer-review

An assessment of the in vivo effects of intravenous lipid emulsion on blood drug concentration and haemodynamics following oro-gastric amitriptyline overdose

Perichon, D., Turfus, S. C., Gerostamoulos, D. & Graudins, A., 2013, In : Clinical Toxicology. 51, 4, p. 208 - 215 8 p.

Research output: Contribution to journalArticleResearchpeer-review

An evaluation of pharmacology curricula in Australian science and health-related degree programs

Lloyd, H. GE., Hinton, T., Bullock, S. P., Babey, A-M., Davis, E. A., Fernandes, L., Hart, J., Musgrave, I. & Ziogas, J., 2013, In : BMC Medical Education. 13, Art. No.:153, p. 1 - 15 15 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File

An examination of cardiovascular collapse induced by eastern brown snake (Pseudonaja textilis) venom

Chaisakul, J., Isbister, G. K., Kuruppu, D. M. S., Konstantakopoulos, N. & Hodgson, W. C., 2013, In : Toxicology Letters. 221, 3, p. 205 - 211 7 p.

Research output: Contribution to journalArticleResearchpeer-review

A Novel Interaction Between Sympathetic Overactivity and Aberrant Regulation of Renin by miR-181a in BPH/2J Genetically Hypertensive Mice

Jackson, K. L., Marques, F. Z., Watson, A., Palma-Rigo, K., Nguyen-Huu, T-P., Morris, B. J., Charchar, F., Davern, P. J. & Head, G. A., 2013, In : Hypertension. 62, 4, p. 775 - 781 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Anti-inflammatory effects of adult stem cells in sustained lung injury: a comparative study

Moodley, Y., Vaghjiani, V., Chan, M. K. J., Baltic, S., Ryan, M., Tchongue, J., Samuel, C. S., Murthi, P., Parolini, O. & Manuelpillai, U. C., 2013, In : PLoS ONE. 8, 8 (Art. No.: e69299), p. 1 - 9 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

A simple method to generate stable cell lines for the analysis of transient protein-protein interactions

Savage, E. E., Wootten, D. L., Christopoulos, A., Sexton, P. & Furness, S. G. B., 2013, In : BioTechniques. 54, 4, p. 217 - 221 5 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File

A structure-activity analysis of biased agonism at the dopamine D2 receptor

Shonberg, J., Klein Herenbrink, C., Lopez, L., Christopoulos, A., Scammells, P. J., Capuano, B. & Lane, J. R. D., 2013, In : Journal of Medicinal Chemistry. 56, 22, p. 9199 - 9221 23 p.

Research output: Contribution to journalArticleResearchpeer-review

Bridging the gap: bitopic ligands of G-protein-coupled receptors

Lane, J. R. D., Sexton, P. M. & Christopoulos, A., 2013, In : Trends in Pharmacological Sciences. 34, 1, p. 59 - 66 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Calcium-sensing receptor-dependent activation of CREB phosphorylation in HEK293 cells and human parathyroid cells

Avlani, V. A., Ma, W., Mun, H., Leach, K., Delbridge, L., Christopoulos, A. & Conigrave, A., 2013, In : American Journal of Physiology - Endocrinology and Metabolism. 304, 10, p. 1097 - 1104 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Calsenilin contributes to neuronal cell death in ischemic stroke

Park, J-S., Manzanero, S., Chang, J-W., Choi, Y., Baik, S-H., Cheng, Y-L., Li, Y., Gwon, A-R., Woo, H-N., Jang, J., Choi, I-Y., Lee, J-Y., Jung, Y-K., Tang, S-C., Sobey, C. G., Arumugam, T. & Jo, D-G., 2013, In : Brain Pathology. 23, 4, p. 402 - 412 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Cardiovascular role of angiotensin type1A receptors in the nucleus of the solitary tract of mice

Abegaz, B., Davern, P. J., Jackson, K. L., Nguyen-Huu, T-P., Bassi, J. K., Connelly, A., Choong, Y-T., Allen, A. M. & Head, G. A., 2013, In : Cardiovascular Research. 100, 2, p. 181 - 191 11 p.

Research output: Contribution to journalArticleResearchpeer-review

CEACAM1: an adhesion molecule that limits blood-brain barrier damage by neutrophils after stroke

Sobey, C. G. & Drummond, G. R., 2013, In : Circulation Research. 113, 8, p. 952 - 953 2 p.

Research output: Contribution to journalLetterOther

CGRP/adrenomedullin

Wootten, D. L., Tilakaratne, N., Christopoulos, A. & Sexton, P., 2013, Handbook of Biologically Active Peptides. Kastin, A. J. (ed.). Second Edition ed. San Diego CA USA: Elsevier, p. 744 - 751 8 p.

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Researchpeer-review

Chronic activation of the low affinity site of beta -adrenoceptors stimulates haemodynamics but exacerbated pressure-overload cardiac remodelling

Kiriazis, H., Tugiono, N., Xu, Q., Gao, X-M., Jennings, N., Ming, Z., Su, Y., Klenowski, P., Summers, R. J., Kaumann, A., Molenaar, P. & Du, X-J., 2013, In : British Journal of Pharmacology. 170, 2, p. 352 - 365 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Chronic NaHS treatment is vasoprotective in high-fat-fed ApoE-/- mice

Ford, A., Al-Magableh, M. R., Gaspari, T. A. & Hart, J. L., 2013, In : International Journal of Vascular Medicine. 2013, Art # 915983, p. 1 - 8 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Comment on "protective arms of the renin-angiotensin system in neurological disease": Reply

Sumners, C., Horiuchi, M., Widdop, R. E., Mccarthy, C., Unger, T. & Steckelings, U. M., Nov 2013, In : Clinical and Experimental Pharmacology and Physiology. 40, 11, p. 838-839 2 p.

Research output: Contribution to journalLetterOtherpeer-review

Cross-neutralisation of the neurotoxic effects of Egyptian cobra venom with commercial tiger snake antivenom

Kornhauser, R. S., Isbister, G. K., O'Leary, M. A., Mirtschin, P., Dunstan, N. & Hodgson, W. C., 2013, In : Basic and Clinical Pharmacology and Toxicology. 112, 2, p. 138 - 143 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Development of human cells with RXFP1 knockdown using retroviral delivery of microRNA against human RXFP1

Yong, K. J., Callander, G. E., Bergin, R., Samuel, C. S. & Bathgate, R. A. D., 2013, In : Italian Journal of Anatomy and Embryology. 118, 1 SUPPL., p. 10-12 3 p.

Research output: Contribution to journalArticleOtherpeer-review

Development of M1 mAChR allosteric and bitopic ligands: Prospective therapeutics for the treatment of cognitive deficits

Davie, B. J., Christopoulos, A. & Scammells, P. J., 2013, In : ACS Chemical Neuroscience. 4, 7, p. 1026 - 1048 23 p.

Research output: Contribution to journalArticleResearchpeer-review

Differential activation and modulation of the glucagon-like peptide-1 receptor by small molecule ligands

Wootten, D. L., Savage, E. E., Willard, F. S., Bueno, A. B., Sloop, K. W., Christopoulos, A. & Sexton, P., 2013, In : Molecular Pharmacology. 83, 4, p. 822 - 834 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Differential evolution and neofunctionalization of snake venom metalloprotease domains

Brust, A., Sunagar, K., Undheim, E. A. B., Vetter, I., Yang, D., Casewell, N. R., Jackson, T. N. W., Koludarov, I., Alewood, P. F., Hodgson, W. C., Lewis, R. J., King, G. F., Antunes, A., Hendrikx, I. & Fry, B. G., 2013, In : Molecular & Cellular Proteomics. 12, 3, p. 651 - 663 13 p.

Research output: Contribution to journalArticleResearchpeer-review