Research Output 1986 2019

2018

INSL5 activates multiple signalling pathways and regulates GLP-1 secretion in NCI-H716 cells

Ang, S. Y., Evans, B. A., Poole, D. P., Bron, R., DiCello, J. J., Bathgate, R. A. D., Kocan, M., Hutchinson, D. S. & Summers, R. J., 1 Apr 2018, In : Journal of Molecular Endocrinology. 60, 3, p. 213-224 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Macrophage migration inhibitory factor is required for NLRP3 inflammasome activation

Lang, T., Lee, J. P. W., Elgass, K., Pinar, A. A., Tate, M. D., Aitken, E. H., Fan, H., Creed, S. J., Deen, N. S., Traore, D. A. K., Mueller, I., Stanisic, D., Baiwog, F. S., Skene, C., Wilce, M. C. J., Mansell, A., Morand, E. F. & Harris, J., 1 Dec 2018, In : Nature Communications. 9, 1, 15 p., 2223.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Mechanisms of signalling and biased agonism in G protein-coupled receptors

Wootten, D. L., Christopoulos, A., Marti-Solano, M., Babu, M. M. & Sexton, P. M., Oct 2018, In : Nature Reviews Molecular Cell Biology. 19, 10, p. 638-653 16 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

Open Access
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Missing Heritability of Hypertension and Our Microbiome: Have we been searching in the wrong place?

Marques, F. Z., 2 Oct 2018, In : Circulation. 138, 14, p. 1381-1383 3 p.

Research output: Contribution to journalEditorialOtherpeer-review

Molecular pharmacology of GPCRs

Langmead, C. J. & Summers, R. J., 1 Nov 2018, In : British Journal of Pharmacology. 175, 21, p. 4005-4008 4 p.

Research output: Contribution to journalEditorialOther

Open Access
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Morphology and function of the lamb ileum following preterm birth

Flores, T. J., Nguyen, V. B., Widdop, R. E., Sutherland, M. R., Polglase, G. R., Abud, H. E. & Black, M. J., 29 Jan 2018, In : Frontiers in Pediatrics. 6, 11 p., 8.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Muscarinic M5 receptors modulate ethanol seeking in rats

Berizzi, A. E., Perry, C. J., Shackleford, D. M., Lindsley, C. W., Jones, C. K., Chen, N. A., Sexton, P. M., Christopoulos, A., Langmead, C. J. & Lawrence, A. J., 1 Jun 2018, In : Neuropsychopharmacology. 43, 7, p. 1510-1517 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Non-neurotoxic activity of Malayan krait (Bungarus candidus) venom from Thailand

Charoenpitakchai, M., Wiwatwarayos, K., Jaisupa, N., Rusmili, M. R. A., Mangmool, S., Hodgson, W. C., Ruangpratheep, C., Chanhome, L. & Chaisakul, J., 9 Mar 2018, In : Journal of Venomous Animals and Toxins Including Tropical Diseases. 24, 1, 9 p., 9.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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NOX2 oxidase expressed in endosomes promotes cell proliferation and prostate tumour development

Harrison, I. P., Vinh, A., Johnson, I. R. D., Luong, R., Drummond, G. R., Sobey, C. G., Tiganis, T., Williams, E. D., O'Leary, J., Brooks, D. A. & Selemidis, S., 23 Oct 2018, In : Oncotarget. 9, 83, p. 35378-35393 16 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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NOx in exhaled breath condensate is related to allergic sensitization in young and middle-aged adults

Aldakheel, F. M., Bourke, J. E., Thomas, P. S., Matheson, M. C., Abramson, M. J., Hamilton, G. S., Lodge, C. J., Thompson, B. R., Haydn Walters, E., Allen, K. J., Erbas, B., Perret, J. L., Dharmage, S. C. & Lowe, A. J., 1 Jan 2018, (Accepted/In press) In : Clinical and Experimental Allergy. 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Peripheral modulation of the endocannabinoid system in metabolic disease

Shrestha, N., Cuffe, J. S. M., Hutchinson, D. S., Headrick, J. P., Perkins, A. V., McAinch, A. J. & Hryciw, D. H., 1 Mar 2018, In : Drug Discovery Today. 23, 3, p. 592-604 13 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

Phase-plate cryo-EM structure of a biased agonistbound human GLP-1 receptor-Gs complex

Liang, Y. L., Khoshouei, M., Glukhova, A., Furness, S. G. B., Zhao, P., Clydesdale, L., Koole, C., Truong, T. T., Thal, D. M., Lei, S., Radjainia, M., Danev, R., Baumeister, W., Wang, M. W., Miller, L. J., Christopoulos, A., Sexton, P. M. & Wootten, D., 1 Mar 2018, In : Nature. 555, 7694, p. 121-125 5 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Population-Based Gut Microbiome Associations With Hypertension

Jama, H., Kaye, D. M. & Marques, F. Z., 9 Nov 2018, In : Circulation Research. 123, 11, p. 1185-1187 3 p.

Research output: Contribution to journalComment / DebateOtherpeer-review

Preassembled GPCR signaling complexes mediate distinct cellular responses to ultralow ligand concentrations

Civciristov, S., Ellisdon, A. M., Suderman, R., Pon, C. K., Evans, B. A., Kleifeld, O., Charlton, S. J., Hlavacek, W. S., Canals, M. & Halls, M. L., 9 Oct 2018, In : Science Signaling. 11, 551, 22 p., eaan1188.

Research output: Contribution to journalArticleResearchpeer-review

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Protease-activated receptor-2 in endosomes signals persistent pain of irritable bowel syndrome

Jimenez-Vargas, N. N., Pattison, L. A., Zhao, P., Lieu, T., Latorre, R., Jensen, D. D., Castro, J., Aurelio, L., Le, G. T., Flynn, B., Herenbrink, C. K., Yeatman, H. R., Edgington-Mitchell, L., Porter, C. J. H., Halls, M. L., Canals, M., Veldhuis, N. A., Poole, D. P., McLean, P., Hicks, G. A. & 7 othersScheff, N., Chen, E., Bhattacharya, A., Schmidt, B. L., Brierley, S. M., Vanner, S. J. & Bunnett, N. W., 31 Jul 2018, In : Proceedings of the National Academy of Sciences of the United States of America. 115, 31, p. E7438-E7447 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Proteomic Characterization of Two Medically Important Malaysian Snake Venoms, Calloselasma rhodostoma (Malayan Pit Viper) and Ophiophagus hannah (King Cobra)

Kunalan, S., Othman, I., Syed Hassan, S. & Hodgson, W. C., 26 Oct 2018, In : Toxins. 10, 11, 36 p., 434.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Proteomic Identification of Interferon-Induced Proteins with Tetratricopeptide Repeats as Markers of M1 Macrophage Polarization

Huang, C., Lewis, C., Borg, N. A., Canals, M., Diep, H., Drummond, G. R., Goode, R. J., Schittenhelm, R. B., Vinh, A., Zhu, M., Kemp-Harper, B., Kleifeld, O. & Stone, M. J., 6 Apr 2018, In : Journal of Proteome Research. 17, 4, p. 1485-1499 15 p.

Research output: Contribution to journalArticleResearchpeer-review

Rattling the border wall: Pathophysiological implications of functional and proteomic venom variation between Mexican and US subspecies of the desert rattlesnake Crotalus scutulatus

Dobson, J., Yang, D. C., op den Brouw, B., Cochran, C., Huynh, T., Kurrupu, S., Sánchez, E. E., Massey, D. J., Baumann, K., Jackson, T. N. W., Nouwens, A., Josh, P., Neri-Castro, E., Alagón, A., Hodgson, W. C. & Fry, B. G., 1 Feb 2018, In : Comparative Biochemistry and Physiology Part - C: Toxicology and Pharmacology. 205, p. 62-69 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Regulation of the human placental (pro)renin receptor-prorenin-angiotensin system by microRNAs

Wang, Y., Lumbers, E. R., Arthurs, A. L., Corbisier de Meaultsart, C., Mathe, A., Avery-Kiejda, K. A., Roberts, C. T., Broughton Pipkin, F., Marques, F. Z., Morris, B. J. & Pringle, K. G., 1 Sep 2018, In : Molecular Human Reproduction. 24, 9, p. 453-464 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Renal nerves contribute to hypertension in Schlager BPH/2J mice

Gueguen, C., Jackson, K. L., Marques, F. Z., Eikelis, N., Phillips, S., Stevenson, E. R., Charchar, F. J., Lambert, G. W., Davern, P. J. & Head, G. A., 10 Dec 2018, In : Hypertension Research. 42, p. 306-318 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Reply to ‘Antipsychotics with similar association kinetics at dopamine D2 receptors differ in extrapyramidal side-effects’

Sykes, D. A., Lane, J. R., Szabo, M., Capuano, B., Javitch, J. A. & Charlton, S. J., 1 Dec 2018, In : Nature Communications. 9, 1, 5 p., 3568.

Research output: Contribution to journalLetterOtherpeer-review

Open Access
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Rosiglitazone and a β3-adrenoceptor agonist are both required for functional browning of white adipocytes in culture

Merlin, J., Sato, M., Chia, L. Y., Fahey, R., Pakzad, M., Nowell, C. J., Summers, R. J., Bengtsson, T., Evans, B. A. & Hutchinson, D. S., 30 May 2018, In : Frontiers in Endocrinology. 9, MAY, 17 p., 249.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Rules of Engagement: GPCRs and G Proteins

Glukhova, A., Draper-Joyce, C. J., Sunahara, R. K., Christopoulos, A., Wootten, D. L. & Sexton, P. M., 7 Sep 2018, In : ACS Pharmacology and Translational Sciences. 1, 2, p. 73-83 11 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

Serelaxin as a novel therapeutic opposing fibrosis and contraction in lung diseases

Lam, M., Royce, S. G., Samuel, C. S. & Bourke, J. E., Jul 2018, In : Pharmacology and Therapeutics. 187, p. 61-70 10 p.

Research output: Contribution to journalArticleOtherpeer-review

Structure-based discovery of selective positive allosteric modulators of antagonists for the M2 muscarinic acetylcholine receptor

Korczynska, M., Clark, M. J., Valant, C., Xu, J., Moo, E. V., Albold, S., Weiss, D. R., Torosyan, H., Huang, W., Kruse, A. C., Lyda, B. R., May, L. T., Baltos, J. A., Sexton, P. M., Kobilka, B. K., Christopoulos, A., Shoichet, B. K. & Sunahara, R. K., 6 Mar 2018, In : Proceedings of the National Academy of Sciences. 115, 10, p. E2419-E2428 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Structure of the adenosine-bound human adenosine A1 receptor-Gi complex

Draper-Joyce, C. J., Khoshouei, M., Thal, D. M., Liang, Y. L., Nguyen, A. T. N., Furness, S. G. B., Venugopal, H., Baltos, J. A., Plitzko, J. M., Danev, R., Baumeister, W., May, L. T., Wootten, D., Sexton, P. M., Glukhova, A. & Christopoulos, A., 20 Jun 2018, In : Nature. 558, 7711, p. 559-565 7 p.

Research output: Contribution to journalArticleResearchpeer-review

The action of a negative allosteric modulator at the dopamine D2 receptor is dependent upon sodium ions

Draper-Joyce, C. J., Verma, R. K., Michino, M., Shonberg, J., Kopinathan, A., Klein Herenbrink, C., Scammells, P. J., Capuano, B., Abramyan, A. M., Thal, D. M., Javitch, J. A., Christopoulos, A., Shi, L. & Lane, J. R., 1 Dec 2018, In : Scientific Reports. 8, 1, 12 p., 1208.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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The structural determinants of the bitopic binding mode of a negative allosteric modulator of the dopamine D2 receptor

Draper-Joyce, C. J., Michino, M., Verma, R. K., Klein Herenbrink, C., Shonberg, J., Kopinathan, A., Scammells, P. J., Capuano, B., Thal, D. M., Javitch, J. A., Christopoulos, A., Shi, L. & Lane, J. R., 1 Feb 2018, In : Biochemical Pharmacology. 148, p. 315-328 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Two distinct domains of the glucagon-like peptide-1 receptor control peptide-mediated biased agonism

Lei, S., Clydesdale, L., Dai, A., Cai, X., Yang, F., Yang, D., Liang, Y-L., Koole, C., Zhao, P., Coudrat, T., Christopoulos, A., Wang, M-W., Wootten, D. & Sexton, P. M., 1 Jan 2018, In : Journal of Biological Chemistry. 293, 24, p. 9370-9387 18 p.

Research output: Contribution to journalArticleResearchpeer-review

Vascular and molecular pharmacology of the metabolically stable CGRP analogue, SAX

Sheykhzade, M., Abdolalizadeh, B., Koole, C., Pickering, D. S., Dreisig, K., Johansson, S. E., Abboud, B. K., Dreier, R., Berg, J. O., Jeppesen, J. L., Sexton, P. M., Edvinsson, L., Wootten, D. & Sams, A., 15 Jun 2018, In : European Journal of Pharmacology. 829, p. 85-92 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Vitamin D3 Supplementation Reduces Subsequent Brain Injury and Inflammation Associated with Ischemic Stroke

Evans, M. A., Kim, H. A., Ling, Y. H., Uong, S., Vinh, A., De Silva, T. M., Arumugam, T. V., Clarkson, A. N., Zosky, G. R., Drummond, G. R., Broughton, B. R. S. & Sobey, C. G., 1 Mar 2018, In : NeuroMolecular Medicine. 20, 1, p. 147-159 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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“Selective” class C G protein-coupled receptor modulators are neutral or biased mGlu5 allosteric ligands

Hellyer, S. D., Albold, S., Wang, T., Chen, A. N. Y., May, L. T., Leach, K. & Gregory, K. J., 1 May 2018, In : Molecular Pharmacology. 93, 5, p. 504-514 11 p.

Research output: Contribution to journalArticleResearchpeer-review

2017

Acute effect of central administration of urotensin II on baroreflex and blood pressure in conscious normotensive rabbits

Lim, K., Sata, Y., Jackson, K. L., Burke, S. L. & Head, G. A., 23 Feb 2017, In : Frontiers in Physiology. 8, FEB, 9 p., 110.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Adenylyl cyclase signalling complexes - pharmacological challenges and opportunities

Halls, M. L. & Cooper, D. M. F., Apr 2017, In : Pharmacology and Therapeutics. 172, p. 171-180 10 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

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Adrenoceptors promote glucose uptake into adipocytes and muscle by an insulin-independent signaling pathway involving mechanistic target of rapamycin complex 2

Mukaida, S., Evans, B. A., Bengtsson, T., Hutchinson, D. S. & Sato, M., 1 Feb 2017, In : Pharmacological Research. 116, p. 87-92 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Advanced atherosclerosis is associated with inflammation, vascular dysfunction and oxidative stress, but not hypertension

Dinh, Q. N., Chrissobolis, S., Diep, H., Chan, C. T., Ferens, D., Drummond, G. R. & Sobey, C. G., Feb 2017, In : Pharmacological Research. p. 70-76 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Airway remodelling and inflammation in asthma are dependent on the extracellular matrix protein fibulin-1c

Liu, G., Cooley, M. A., Nair, P. M., Donovan, C., Hsu, A. C., Jarnicki, A. G., Haw, T. J., Hansbro, N. G., Ge, Q., Brown, A. C., Tay, H., Foster, P. S., Wark, P. A., Horvat, J. C., Bourke, J. E., Grainge, C. L., Argraves, W. S., Oliver, B. G., Knight, D. A., Burgess, J. K. & 1 othersHansbro, P. M., 1 Dec 2017, In : Journal of Pathology. 243, 4, p. 510-523 14 p.

Research output: Contribution to journalArticleResearchpeer-review

A kinetic view of GPCR allostery and biased agonism

Lane, J. R., May, L. T., Parton, R. G., Sexton, P. M. & Christopoulos, A., 18 Aug 2017, In : Nature Chemical Biology. 13, 9, p. 929-937 9 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

Open Access
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Allosteric modulation as a unifying mechanism for receptor function and regulation

Changeux, J-P. & Christopoulos, A., 1 Sep 2017, In : Diabetes, Obesity and Metabolism. 19, p. 4-21 18 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

Open Access
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Allostery and Biased Agonism at Class B G Protein-Coupled Receptors

Wootten, D., Miller, L. J., Koole, C., Christopoulos, A. & Sexton, P. M., 11 Jan 2017, In : Chemical Reviews. 117, 1, p. 111-138 28 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

Amyloidogenicity at a Distance: How Distal Protein Regions Modulate Aggregation in Disease

Lucato, C. M., Lupton, C. J., Halls, M. L. & Ellisdon, A. M., 5 May 2017, In : Journal of Molecular Biology. 429, 9, p. 1289-1304 16 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

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Anakinra reduces blood pressure and renal fibrosis in one kidney/DOCA/salt-induced hypertension

Ling, Y. H., Krishnan, S. M., Chan, C. T., Diep, H., Ferens, D., Chin-Dusting, J., Kemp-Harper, B. K., Samuel, C. S., Hewitson, T. D., Latz, E., Mansell, A., Sobey, C. G. & Drummond, G. R., Feb 2017, In : Pharmacological Research. 116, p. 77-86 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Anti-fibrotic actions of relaxin

Samuel, C. S., Royce, S. G., Hewitson, T. D., Denton, K. M., Cooney, T. E. & Bennett, R. G., 1 May 2017, In : British Journal of Pharmacology. 174, 10, p. 962-976 15 p.

Research output: Contribution to journalArticleOtherpeer-review

Anti-fibrotic potential of AT2 receptor agonists

Wang, Y., Del Borgo, M., Lee, H. W., Baraldi, D., Hirmiz, B., Gaspari, T. A., Denton, K. M., Aguilar, M-I., Samuel, C. S. & Widdop, R. E., 31 Aug 2017, In : Frontiers in Pharmacology. 8, 7 p., 564.

Research output: Contribution to journalArticleOtherpeer-review

Open Access
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Antivenom for neuromuscular paralysis resulting from snake envenoming

Silva, A., Hodgson, W. C. & Isbister, G. K., 19 Apr 2017, In : Toxins. 9, 4, 17 p., 143.

Research output: Contribution to journalReview ArticleResearchpeer-review

Open Access
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Antivenom for snake venom-induced neuromuscular paralysis

Silva, A., Maduwage, K., Buckley, N. A., Lalloo, D. G., de Silva, H. J. & Isbister, G. K., 21 Mar 2017, In : Cochrane Database of Systematic Reviews. 2017, 3, 12 p., CD012604.

Research output: Contribution to journalArticleResearchpeer-review