Research Output 1986 2019

2019

6-Phenylpyrimidin-4-ones as Positive Allosteric Modulators at the M1 mAChR: The Determinants of Allosteric Activity

Jorg, M. T., van der Westhuizen, E. T., Khajehali, E., Burger, W. A. C., White, J., Choy, K. H. C., Tobin, A. B., Sexton, P. M., Valant, C., Capuano, B., Christopoulos, A. & Scammells, P. J., 20 Mar 2019, In : ACS Chemical Neuroscience. 10, 3, p. 1099-1114 16 p.

Research output: Contribution to journalArticleResearchpeer-review

Adrenoceptor regulation of mTOR in muscle and adipose tissue

Chia, L. Y., Evans, B., Mukaida, S., Bengtsson, T., Hutchinson, D. & Sato, M., 2019, (Accepted/In press) In : British Journal of Pharmacology. 38 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

A ligand-induced structural change in fatty acid-binding protein 1 is associated with potentiation of peroxisome proliferator-activated receptor α agonists

Patil, R., Mohanty, B., Liu, B., Chandrashekaran, I. R., Headey, S. J., Williams, M. L., Clements, C. S., Ilyichova, O., Doak, B. C., Genissel, P., Weaver, R., Vuillard, L., Halls, M. L., Porter, C. J. H. & Scanlon, M. J., 8 Mar 2019, In : Journal of Biological Chemistry. 294, 10, p. 3720-3734 15 p.

Research output: Contribution to journalArticleResearchpeer-review

Effects of high- and low-dose aspirin on adaptive immunity and hypertension in the stroke-prone spontaneously hypertensive rat

Khan, S. I., Shihata, W. A., Andrews, K. L., Lee, M. K. S., Moore, X-L., Jefferis, A-M., Vinh, A., Gaspari, T., Dragoljevic, D., Jennings, G. L., Murphy, A. J. & Chin-Dusting, J. P. F., 1 Jan 2019, In : FASEB Journal. 33, 1, p. 1510-1521 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Human amnion epithelial cells and their soluble factors reduce liver fibrosis in murine non-alcoholic steatohepatitis

Kuk, N., Hodge, A., Sun, Y., Correia, J., Alhomrani, M., Samuel, C., Moore, G., Lim, R. & Sievert, W., 1 Mar 2019, (Accepted/In press) In : Journal of Gastroenterology and Hepatology (Australia). 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Identification of monellin as the first naturally derived proteinaceous allosteric agonist of metabotropic glutamate receptor 5

Chen, A. N. Y., Hellyer, S. D., Trinh, P. N. H., Leach, K. & Gregory, K. J., 14 Apr 2019, (Accepted/In press) In : Basic and Clinical Pharmacology and Toxicology. 22 p.

Research output: Contribution to journalArticleResearchpeer-review

Kinetic and system bias as drivers of metabotropic glutamate receptor 5 allosteric modulator pharmacology

Sengmany, K., Hellyer, S. D., Albold, S., Wang, T., Conn, P. J., May, L. T., Christopoulos, A., Leach, K. & Gregory, K. J., 1 May 2019, In : Neuropharmacology. 149, p. 83-96 14 p.

Research output: Contribution to journalArticleResearchpeer-review

The effect of diet on hypertensive pathology: is there a link via gut microbiota-driven immune-metabolism?

Jama, H. A., Beale, A., Shihata, W. & Marques, F. Z., 3 Apr 2019, (Accepted/In press) In : Cardiovascular Research.

Research output: Contribution to journalArticleResearchpeer-review

The gut microbiota and blood pressure in experimental models

Jama, H. A., Kaye, D. M. & Marques, F. Z., 1 Mar 2019, In : Current Opinion in Nephrology and Hypertension. 28, 2, p. 97-104 8 p.

Research output: Contribution to journalArticleResearchpeer-review

The use of live cell imaging and automated image analysis to assist with determining optimal parameters for angiogenic assay in vitro

Huuskes, B. M., DeBuque, R. J., Kerr, P. G., Samuel, C. S. & Ricardo, S. D., 10 Apr 2019, In : Frontiers in Cell and Developmental Biology. 7, 14 p., 45.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
2018

Acute or Delayed Systemic Administration of Human Amnion Epithelial Cells Improves Outcomes in Experimental Stroke

Evans, M. A., Lim, R., Kim, H. A., Chu, H. X., Gardiner-Mann, C. V., Taylor, K. W. E., Chan, C. T., Brait, V. H., Lee, S., Dinh, Q. N., Vinh, A., Phan, T. G., Srikanth, V. K., Ma, H., Arumugam, T. V., Fann, D. Y., Poh, L., Hunt, C. P. J., Pouton, C. W., Haynes, J. M. & 12 othersSelemidis, S., Kwan, W., Teo, L., Bourne, J. A., Neumann, S., Young, S., Gowing, E. K., Drummond, G. R., Clarkson, A. N., Wallace, E. M., Sobey, C. G. & Broughton, B. R. S., 1 Mar 2018, In : Stroke. 49, 3, p. 700-709 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Age-related differential structural and transcriptomic responses in the hypertensive heart

Marques, F. Z., Chu, P. Y., Ziemann, M., Kaspi, A., Kiriazis, H., Du, X. J., El-Osta, A. & Kaye, D. M., 9 Jul 2018, In : Frontiers in Physiology. 9, JUL, 13 p., 817.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File

Amnion epithelial cells - A novel therapy for ischemic stroke?

Evans, M. A., Broughton, B. R. S., Drummond, G. R., Ma, H., Phan, T. G., Wallace, E. M., Lim, R. & Sobey, C. G., 1 Aug 2018, In : Neural Regeneration Research. 13, 8, p. 1346-1349 4 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

Open Access
File

A polymorphism in the noradrenaline transporter gene is associated with increased blood pressure in patients with resistant hypertension

Eikelis, N., Marques, F. Z., Hering, D., Marusic, P., Head, G. A., Walton, A. S., Lambert, E. A., Esler, M. D., Sari, C. I., Schlaich, M. P. & Lambert, G. W., 1 Jul 2018, In : Journal of hypertension. 36, 7, p. 1571-1577 7 p.

Research output: Contribution to journalArticleResearchpeer-review

A Structure-Activity Relationship Study of Bitopic N 6-Substituted Adenosine Derivatives as Biased Adenosine A1 Receptor Agonists

Aurelio, L., Baltos, J. A., Ford, L., Nguyen, A. T. N., Jörg, M., Devine, S. M., Valant, C., White, P. J., Christopoulos, A., May, L. T. & Scammells, P. J., 8 Mar 2018, In : Journal of Medicinal Chemistry. 61, 5, p. 2087-2103 17 p.

Research output: Contribution to journalArticleResearchpeer-review

A Thieno[2,3-d]pyrimidine Scaffold is a Novel Negative Allosteric Modulator of the Dopamine D2 Receptor

Fyfe, T. J., Zarzycka, B., Lim, H. D., Kellam, B., Mistry, S. N., Katrich, V., Scammells, P. J., Lane, J. R. & Capuano, B., 2018, (Accepted/In press) In : Journal of Medicinal Chemistry. 82 p.

Research output: Contribution to journalArticleResearchpeer-review

Beyond gut feelings: How the gut microbiota regulates blood pressure

Marques, F. Z., Mackay, C. R. & Kaye, D. M., 1 Jan 2018, In : Nature Reviews Cardiology. 15, 1, p. 20-32 13 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

Characterization of signalling and regulation of common calcitonin receptor splice variants and polymorphisms

Dal Maso, E., Just, R., Hick, C., Christopoulos, A., Sexton, P. M., Wootten, D. & Furness, S. G. B., 1 Feb 2018, In : Biochemical Pharmacology. 148, p. 111-129 19 p.

Research output: Contribution to journalArticleResearchpeer-review

Circadian differences in the contribution of the brain renin-angiotensin system in genetically hypertensive mice

Jackson, K. L., Marques, F. Z., Lim, K., Davern, P. J. & Head, G. A., 19 Mar 2018, In : Frontiers in Physiology. 9, 15 p., 231.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File

Comparative genotypic and phenotypic analysis of human peripheral blood monocytes and surrogate monocyte-like cell lines commonly used in metabolic disease research

Riddy, D. M., Goy, E., Delerive, P., Summers, R. J. & Langmead, C. J., 1 May 2018, In : PLoS ONE. 13, 5, 19 p., e0197177.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File

Dapagliflozin attenuates human vascular endothelial cell activation and induces vasorelaxation: A potential mechanism for inhibition of atherogenesis

Gaspari, T., Spizzo, I., Liu, H., Hu, Y., Simpson, R. W., Widdop, R. E. & Dear, A. E., 1 Jan 2018, In : Diabetes and Vascular Disease Research. 15, 1, p. 64-73 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File

Defining the role of post-synaptic α-neurotoxins in paralysis due to snake envenoming in humans

Silva, A., Cristofori-Armstrong, B., Rash, L. D., Hodgson, W. C. & Isbister, G. K., 1 Dec 2018, In : Cellular and Molecular Life Sciences. 75, 23, p. 4465-4478 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Diet-induced vitamin D deficiency has no effect on acute post-stroke outcomes in young male mice

Evans, M. A., Kim, H. A., De Silva, T. M., Arumugam, T. V., Clarkson, A. N., Drummond, G. R., Zosky, G. R., Broughton, B. R. S. & Sobey, C. G., 1 Nov 2018, In : Journal of Cerebral Blood Flow and Metabolism. 38, 11, p. 1968-1978 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Endothelial Progenitor Cells and Vascular Health in Dialysis Patients

Huuskes, B. M., DeBuque, R. J., Polkinghorne, K. R., Samuel, C. S., Kerr, P. G. & Ricardo, S. D., Jan 2018, In : Kidney International Reports. 3, 1, p. 205-211 7 p.

Research output: Contribution to journalLetterResearchpeer-review

Open Access
File

Evidence that NF-κB and MAPK Signaling Promotes NLRP Inflammasome Activation in Neurons Following Ischemic Stroke

Fann, D. Y. W., Lim, Y. A., Cheng, Y. L., Lok, K. Z., Chunduri, P., Baik, S. H., Drummond, G. R., Dheen, S. T., Sobey, C. G., Jo, D. G., Chen, C. L. H. & Arumugam, T. V., Feb 2018, In : Molecular Neurobiology. 55, 2, p. 1082-1096 15 p.

Research output: Contribution to journalArticleResearchpeer-review

Extracellular loops 2 and 3 of the calcitonin receptor selectively modify agonist binding and efficacy

Dal Maso, E., Zhu, Y., Pham, V., Reynolds, C. A., Deganutti, G., Hick, C. A., Yang, D., Christopoulos, A., Hay, D. L., Wang, M. W., Sexton, P. M., Furness, S. G. B. & Wootten, D., 1 Apr 2018, In : Biochemical Pharmacology. 150, p. 214-244 31 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File

Fluorescently Labeled Morphine Derivatives for Bioimaging Studies

Lam, R., Gondin, A. B., Canals, M., Kellam, B., Briddon, S. J., Graham, B. & Scammells, P. J., 8 Feb 2018, In : Journal of Medicinal Chemistry. 61, 3, p. 1316-1329 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Glucagon-like peptide-1 receptor internalisation controls spatiotemporal signalling mediated by biased agonists

Fletcher, M. M., Halls, M. L., Zhao, P., Clydesdale, L., Christopoulos, A., Sexton, P. M. & Wootten, D., 1 Oct 2018, In : Biochemical Pharmacology. 156, p. 406-419 14 p.

Research output: Contribution to journalArticleResearchpeer-review

G protein–coupled receptors targeting insulin resistance, obesity, and type 2 diabetes mellitus

Riddy, D. M., Delerive, P., Summers, R. J., Sexton, P. & Langmead, C. J., 1 Jan 2018, In : Pharmacological Reviews. 70, 1, p. 39-67 29 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

Hexarelin treatment preserves myocardial function and reduces cardiac fibrosis in mouse model of acute myocardial infarction

McDonald, H., Peart, J., Kurniawan, N., Galloway, G., Royce, S., Samuel, C. S. & Chen, C., 13 May 2018, In : Physiological Reports. 6, 9, 14 p., e13699.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File

Identification of global and ligand-specific calcium sensing receptor activation mechanisms S

Keller, A., Kufareva, I., Josephs, T. M., Diao, J., Mai, V. T-V., Conigrave, A. D., Christopoulos, A., Gregory, K. J. & Leach, K., 1 Jun 2018, In : Molecular Pharmacology. 93, 6, p. 619-630 12 p.

Research output: Contribution to journalArticleResearchpeer-review

IL-33 modulates inflammatory brain injury but exacerbates systemic immunosuppression following ischemic stroke

Zhang, S. R., Piepke, M., Chu, H. X., Broughton, B. R. S., Shim, R., Wong, C. H. Y., Lee, S., Evans, M. A., Vinh, A., Sakkal, S., Arumugam, T. V., Magnus, T., Huber, S., Gelderblom, M., Drummond, G. R., Sobey, C. G. & Kim, H. A., 20 Sep 2018, In : JCI Insight. 3, 18, 16 p., e121560.

Research output: Contribution to journalArticleResearchpeer-review

Inflammation-associated changes in DOR expression and function in the mouse colon

Dicello, J. J., Saito, A., Rajasekhar, P., Eriksson, E. M., McQuade, R., Nowell, C., Sebastian, B., Fichna, J., Veldhuis, N. A., Canals, M., Bunnett, N., Carbone, S. E. & Poole, D. P., 1 Oct 2018, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 315, 4, p. G544-G559 39 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File

Insights into endotoxin-mediated lung inflammation and future treatment strategies

Chakraborty, A., Boer, J. C., Selomulya, C., Plebanski, M. & Royce, S. G., 2 Nov 2018, In : Expert Review of Respiratory Medicine. 12, 11, p. 941-955 15 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

INSL5 activates multiple signalling pathways and regulates GLP-1 secretion in NCI-H716 cells

Ang, S. Y., Evans, B. A., Poole, D. P., Bron, R., DiCello, J. J., Bathgate, R. A. D., Kocan, M., Hutchinson, D. S. & Summers, R. J., 1 Apr 2018, In : Journal of Molecular Endocrinology. 60, 3, p. 213-224 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File

Macrophage migration inhibitory factor is required for NLRP3 inflammasome activation

Lang, T., Lee, J. P. W., Elgass, K., Pinar, A. A., Tate, M. D., Aitken, E. H., Fan, H., Creed, S. J., Deen, N. S., Traore, D. A. K., Mueller, I., Stanisic, D., Baiwog, F. S., Skene, C., Wilce, M. C. J., Mansell, A., Morand, E. F. & Harris, J., 1 Dec 2018, In : Nature Communications. 9, 1, 15 p., 2223.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File

Mechanisms of signalling and biased agonism in G protein-coupled receptors

Wootten, D. L., Christopoulos, A., Marti-Solano, M., Babu, M. M. & Sexton, P. M., Oct 2018, In : Nature Reviews Molecular Cell Biology. 19, 10, p. 638-653 16 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

Open Access
File

Missing Heritability of Hypertension and Our Microbiome: Have we been searching in the wrong place?

Marques, F. Z., 2 Oct 2018, In : Circulation. 138, 14, p. 1381-1383 3 p.

Research output: Contribution to journalEditorialOtherpeer-review

Molecular pharmacology of GPCRs

Langmead, C. J. & Summers, R. J., 1 Nov 2018, In : British Journal of Pharmacology. 175, 21, p. 4005-4008 4 p.

Research output: Contribution to journalEditorialOther

Open Access
File

Morphology and function of the lamb ileum following preterm birth

Flores, T. J., Nguyen, V. B., Widdop, R. E., Sutherland, M. R., Polglase, G. R., Abud, H. E. & Black, M. J., 29 Jan 2018, In : Frontiers in Pediatrics. 6, 11 p., 8.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File

Muscarinic M5 receptors modulate ethanol seeking in rats

Berizzi, A. E., Perry, C. J., Shackleford, D. M., Lindsley, C. W., Jones, C. K., Chen, N. A., Sexton, P. M., Christopoulos, A., Langmead, C. J. & Lawrence, A. J., 1 Jun 2018, In : Neuropsychopharmacology. 43, 7, p. 1510-1517 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File

Non-neurotoxic activity of Malayan krait (Bungarus candidus) venom from Thailand

Charoenpitakchai, M., Wiwatwarayos, K., Jaisupa, N., Rusmili, M. R. A., Mangmool, S., Hodgson, W. C., Ruangpratheep, C., Chanhome, L. & Chaisakul, J., 9 Mar 2018, In : Journal of Venomous Animals and Toxins Including Tropical Diseases. 24, 1, 9 p., 9.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File

NOX2 oxidase expressed in endosomes promotes cell proliferation and prostate tumour development

Harrison, I. P., Vinh, A., Johnson, I. R. D., Luong, R., Drummond, G. R., Sobey, C. G., Tiganis, T., Williams, E. D., O'Leary, J., Brooks, D. A. & Selemidis, S., 23 Oct 2018, In : Oncotarget. 9, 83, p. 35378-35393 16 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File

NOx in exhaled breath condensate is related to allergic sensitization in young and middle-aged adults

Aldakheel, F. M., Bourke, J. E., Thomas, P. S., Matheson, M. C., Abramson, M. J., Hamilton, G. S., Lodge, C. J., Thompson, B. R., Haydn Walters, E., Allen, K. J., Erbas, B., Perret, J. L., Dharmage, S. C. & Lowe, A. J., 1 Jan 2018, (Accepted/In press) In : Clinical and Experimental Allergy. 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Peripheral modulation of the endocannabinoid system in metabolic disease

Shrestha, N., Cuffe, J. S. M., Hutchinson, D. S., Headrick, J. P., Perkins, A. V., McAinch, A. J. & Hryciw, D. H., 1 Mar 2018, In : Drug Discovery Today. 23, 3, p. 592-604 13 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

Phase-plate cryo-EM structure of a biased agonistbound human GLP-1 receptor-Gs complex

Liang, Y. L., Khoshouei, M., Glukhova, A., Furness, S. G. B., Zhao, P., Clydesdale, L., Koole, C., Truong, T. T., Thal, D. M., Lei, S., Radjainia, M., Danev, R., Baumeister, W., Wang, M. W., Miller, L. J., Christopoulos, A., Sexton, P. M. & Wootten, D., 1 Mar 2018, In : Nature. 555, 7694, p. 121-125 5 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File