Research Output

2020

A new pathway to airway relaxation: Targeting the "other" cyclase in asthma

Lam, M. & Bourke, J. E., 1 Jan 2020, In : American Journal of Respiratory Cell and Molecular Biology. 62, 1, p. 3-4 2 p.

Research output: Contribution to journalEditorialOtherpeer-review

Open Access
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A novel approach for non‐invasive lung imaging and targeting lung immune cells

Chakraborty, A., Royce, S. G., Selomulya, C. & Plebanski, M., 1 Mar 2020, In : International Journal of Molecular Sciences. 21, 5, 18 p., 1613.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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1 Citation (Scopus)

Assays for Measuring the Role of MIF in NLRP3 Inflammasome Activation

Pinar, A. A. & Harris, J., 2020, Macrophage Migration Inhibitory Factor: Methods and Protocols. Harris, J. & Morand, E. F. (eds.). New York, NY: Humana Press, Vol. 2080. p. 159-172 14 p. (Methods in Molecular Biology).

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Otherpeer-review

Decreased Placental FPR2 in Early Pregnancies That Later Developed Small-For-Gestation Age: A Potential Role of FPR2 in the Regulation of Epithelial-Mesenchymal Transition

Murthi, P., Rajaraman, G., Erwich, J. J. H. M. & Dimitriadis, E., 10 Apr 2020, In : Cells. 9, 4, 19 p., 921.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Detailed In Vitro Pharmacological Characterization of Clinically Tested Negative Allosteric Modulators of the Metabotropic Glutamate Receptor 5

Arsova, A., Møller, T. C., Vedel, L., Hansen, J. L., Foster, S. R., Gregory, K. J. & Bräuner-Osborne, H., 1 Jul 2020, In : Molecular Pharmacology. 98, 1, p. 49-60 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Empagliflozin modulates renal sympathetic and heart rate baroreflexes in a rabbit model of diabetes

Gueguen, C., Burke, S. L., Barzel, B., Eikelis, N., Watson, A. M. D., Jha, J. C., Jackson, K. L., Sata, Y., Lim, K., Lambert, G. W., Jandeleit-Dahm, K. A. M., Cooper, M. E., Thomas, M. C. & Head, G. A., Jul 2020, In : Diabetologia. 63, 7, p. 1424–1434 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Granzyme A in Chikungunya and Other Arboviral Infections

Schanoski, A. S., Le, T. T., Kaiserman, D., Rowe, C., Prow, N. A., Barboza, D. D., Santos, C. A., Zanotto, P. M. A., Magalhães, K. G., Aurelio, L., Muller, D., Young, P., Zhao, P., Bird, P. I. & Suhrbier, A., 14 Jan 2020, In : Frontiers in Immunology. 10, 14 p., 3083.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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1 Citation (Scopus)

Hydroxychloroquine mitigates the production of 8-isoprostane and improves vascular dysfunction: Implications for treating preeclampsia

Abd Rahman, R., Murthi, P., Singh, H., Gurungsinghe, S., Leaw, B., Mockler, J. C., Lim, R. & Wallace, E. M., Apr 2020, In : International Journal of Molecular Sciences. 21, 7, 14 p., 2504.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Identification of monellin as the first naturally derived proteinaceous allosteric agonist of metabotropic glutamate receptor 5

Chen, A. N. Y., Hellyer, S. D., Trinh, P. N. H., Leach, K. & Gregory, K. J., Jun 2020, In : Basic & Clinical Pharmacology & Toxicology. 126, S6, p. 104-115 12 p.

Research output: Contribution to journalArticleResearchpeer-review

1 Citation (Scopus)

Imbalance of the renin-angiotensin system may contribute to inflammation and fibrosis in IBD: a novel therapeutic target?

Garg, M., Royce, S. G., Tikellis, C., Shallue, C., Batu, D., Velkoska, E., Burrell, L. M., Patel, S. K., Beswick, L., Jackson, A., Britto, K., Lukies, M., Sluka, P., Wardan, H., Hirokawa, Y., Tan, C. W., Faux, M., Burgess, A. W., Hosking, P., Monagle, S. & 3 others, Thomas, M., Gibson, P. R. & Lubel, J., 1 May 2020, In : Gut. 69, 5, p. 841-851 11 p.

Research output: Contribution to journalArticleResearchpeer-review

12 Citations (Scopus)
Open Access
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1 Citation (Scopus)

Isolation and pharmacological characterization of α-Elapitoxin-Na1a, a novel short-chain postsynaptic neurotoxin from the venom of the Chinese Cobra (Naja atra)

Liang, Q., Huynh, T. M., Isbister, G. K. & Hodgson, W. C., 28 May 2020, (Accepted/In press) In : Biochemical Pharmacology. 8 p., 114059.

Research output: Contribution to journalArticleResearchpeer-review

Letter: intestinal inflammation, COVID-19 and gastrointestinal ACE2 - exploring RAS inhibitors

Garg, M., Royce, S. G. & Lubel, J. S., 6 May 2020, (Accepted/In press) In : Alimentary Pharmacology & Therapeutics. 2 p.

Research output: Contribution to journalLetterOtherpeer-review

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Nitric Oxide Resistance, Induced in the Myocardium by Diabetes, Is Circumvented by the Nitric Oxide Redox Sibling, Nitroxyl

Qin, C. X., Anthonisz, J., Leo, C. H., Kahlberg, N., Velagic, A., Li, M., Jap, E., Woodman, O. L., Parry, L. J., Horowitz, J. D., Kemp-Harper, B. K. & Ritchie, R. H., 1 Jan 2020, In : Antioxidants and Redox Signaling. 32, 1, p. 60-78 19 p.

Research output: Contribution to journalArticleResearchpeer-review

Nitroxyl: A Novel Strategy to Circumvent Diabetes Associated Impairments in Nitric Oxide Signaling

Velagic, A., Qin, C., Woodman, O. L., Horowitz, J. D., Ritchie, R. H. & Kemp-Harper, B. K., 19 May 2020, In : Frontiers in Pharmacology. 11, 18 p., 727.

Research output: Contribution to journalReview ArticleResearchpeer-review

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Renal functional effects of the highly selective AT2R agonist, β-Pro7 Ang III, in normotensive rats

Hilliard Krause, L. M., Kemp, B. A., Tan, A. S. J., Jones, E. S., Del Borgo, M. P., Aguilar, M. I., Denton, K. M., Carey, R. M. & Widdop, R. E., 17 Apr 2020, In : Clinical Science. 134, 7, p. 871-884 14 p.

Research output: Contribution to journalArticleResearchpeer-review

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Spatial Properties of Reactive Oxygen Species Govern Pathogen-Specific Immune System Responses

To, E. E., O'Leary, J. J., O'Neill, L. A. J., Vlahos, R., Bozinovski, S., Porter, C. J. H., Brooks, R. D., Brooks, D. A. & Selemidis, S., 24 Mar 2020, In : Antioxidants and Redox Signaling. 32, 13, p. 982-992 11 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

Targeting the NLRP3 inflammasome to treat cardiovascular fibrosis

Pinar, A. A., Scott, T. E., Huuskes, B. M., Tapia Cáceres, F. E., Kemp-Harper, B. K. & Samuel, C. S., May 2020, In : Pharmacology and Therapeutics. 209, 22 p., 107511.

Research output: Contribution to journalReview ArticleResearchpeer-review

1 Citation (Scopus)

The anti-fibrotic actions of relaxin are mediated through AT2R-associated protein phosphatases via RXFP1-AT2R functional crosstalk in human cardiac myofibroblasts

Wang, C., Pinar, A. A., Widdop, R. E., Hossain, M. A., Bathgate, R. A. D., Denton, K. M., Kemp-Harper, B. K. & Samuel, C. S., 16 Apr 2020, (Accepted/In press) In : The FASEB Journal. 17 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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The Effects of Early-Onset Pre-Eclampsia on Placental Creatine Metabolism in the Third Trimester

Ellery, S. J., Murthi, P., Gatta, P. A. D., May, A. K., Davies-Tuck, M. L., Kowalski, G. M., Callahan, D. L., Bruce, C. R., Wallace, E. M., Walker, D. W., Dickinson, H. & Snow, R. J., 26 Jan 2020, In : International Journal of Molecular Sciences. 21, 3, 14 p., 806.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Transition of Nano-Architectures Through Self-Assembly of Lipidated β3-Tripeptide Foldamers

Habila, N., Kulkarni, K., Lee, T-H., Al-Garawi, Z. S., Serpell, L. C., Aguilar, M-I. & Del Borgo, M. P., 31 Mar 2020, In : Frontiers in Chemistry. 8, 11 p., 217.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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2019

6-Phenylpyrimidin-4-ones as Positive Allosteric Modulators at the M1 mAChR: The Determinants of Allosteric Activity

Jorg, M. T., van der Westhuizen, E. T., Khajehali, E., Burger, W. A. C., White, J., Choy, K. H. C., Tobin, A. B., Sexton, P. M., Valant, C., Capuano, B., Christopoulos, A. & Scammells, P. J., 20 Mar 2019, In : ACS Chemical Neuroscience. 10, 3, p. 1099-1114 16 p.

Research output: Contribution to journalArticleResearchpeer-review

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Adrenoceptor regulation of the mechanistic target of rapamycin in muscle and adipose tissue

Chia, L. Y., Evans, B., Mukaida, S., Bengtsson, T., Hutchinson, D. & Sato, M., 1 Jul 2019, In : British Journal of Pharmacology. 176, 14, p. 2433-2448 16 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

Open Access
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2 Citations (Scopus)

A ligand-induced structural change in fatty acid-binding protein 1 is associated with potentiation of peroxisome proliferator-activated receptor α agonists

Patil, R., Mohanty, B., Liu, B., Chandrashekaran, I. R., Headey, S. J., Williams, M. L., Clements, C. S., Ilyichova, O., Doak, B. C., Genissel, P., Weaver, R., Vuillard, L., Halls, M. L., Porter, C. J. H. & Scanlon, M. J., 8 Mar 2019, In : The Journal of Biological Chemistry. 294, 10, p. 3720-3734 15 p.

Research output: Contribution to journalArticleResearchpeer-review

2 Citations (Scopus)

An in vivo examination of the differences between rapid cardiovascular collapse and prolonged hypotension induced by snake venom

Kakumanu, R., Kemp-Harper, B. K., Silva, A., Kuruppu, S., Isbister, G. K. & Hodgson, W. C., 27 Dec 2019, In : Scientific Reports. 9, 1, 9 p., 20231.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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1 Citation (Scopus)

A Novel Epigenetic Drug-Eluting Balloon Angioplasty Device: Evaluation in a Large Animal Model of Neointimal Hyperplasia

Liu, H., Byrne, M., Perlmutter, P., Walker, A., Sama, G. R., Subbiah, J., Ozcelik, B., Widdop, R. E., Gaspari, T. A., Byron, K., Chen, Y-C., Kaye, D. M. & Dear, A. E., 30 Dec 2019, In : Cardiovascular Drugs and Therapy. 33, 6, p. 687-692 6 p.

Research output: Contribution to journalArticleResearchpeer-review

1 Citation (Scopus)

A Series of Analogues to the AT 2 R Prototype Antagonist C38 Allow Fine Tuning of the Previously Reported Antagonist Binding Mode

Isaksson, R., Lindman, J., Wannberg, J., Sallander, J., Backlund, M., Baraldi, D., Widdop, R., Hallberg, M., Åqvist, J., Gutierrez de Teran, H., Gising, J. & Larhed, M., 1 Jan 2019, In : ChemistryOpen. 8, 1, p. 114-125 12 p.

Research output: Contribution to journalArticleResearchpeer-review

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3 Citations (Scopus)

AT1R-AT2R-RXFP1 functional crosstalk in myofibroblasts: Impact on the therapeutic targeting of renal and cardiac fibrosis

Chow, B. S. M., Kocan, M., Shen, M., Wang, Y., Han, L., Chew, J. Y., Wang, C., Bosnyak, S., Mirabito-Colafella, K. M., Barsha, G., Wigg, B., Johnstone, E. K. M., Hossain, M. A., Pfleger, K. D. G., Denton, K. M., Widdop, R. E., Summers, R. J., Bathgate, R. A. D., Hewitson, T. D. & Samuel, C. S., 1 Jan 2019, In : Journal of the American Society of Nephrology. 30, 11, p. 2191-2207 17 p.

Research output: Contribution to journalArticleResearchpeer-review

3 Citations (Scopus)

A Thieno[2,3-d]pyrimidine Scaffold is a Novel Negative Allosteric Modulator of the Dopamine D2 Receptor

Fyfe, T. J., Zarzycka, B., Lim, H. D., Kellam, B., Mistry, S. N., Katrich, V., Scammells, P. J., Lane, J. R. & Capuano, B., 1 Oct 2019, In : Journal of Medicinal Chemistry. 62, 1, p. 174-206 33 p.

Research output: Contribution to journalArticleResearchpeer-review

2 Citations (Scopus)

Atypical cannabinoid ligands O-1602 and O-1918 administered chronically in diet-induced obesity

Simcocks, A. C., Jenkin, K. A., O’Keefe, L., Samuel, C. S., Mathai, M. L., McAinch, A. J. & Hryciw, D. H., Mar 2019, In : Endocrine Connections. 8, 3, p. 203-216 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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2 Citations (Scopus)

BRL37344 stimulates GLUT4 translocation and glucose uptake in skeletal muscle via β 2 -adrenoceptors without causing classical receptor desensitization

Mukaida, S., Sato, M., Öberg, A. I., Dehvari, N., Olsen, J. M., Kocan, M., Halls, M. L., Merlin, J., Sandström, A. L., Csikasz, R. I., Evans, B. A., Summers, R. J., Hutchinson, D. S. & Bengtsson, T., 1 May 2019, In : American Journal of Physiology - Regulatory Integrative and Comparative Physiology. 316, 5, p. R666-R677 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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2 Citations (Scopus)

Cardioprotective actions of the annexin-A1 N-terminal peptide, AC2-26, against myocardial infarction

Qin, C. X., Rosli, S., Deo, M., Cao, N., Walsh, J., Tate, M., Alexander, A. E., Donner, D., Horlock, D., Li, R., Kiriazis, H., Lee, M. K. S., Bourke, J. E., Yang, Y., Murphy, A. J., Du, X-J., Gao, X. M. & Ritchie, R. H., 3 Apr 2019, In : Frontiers in Pharmacology. 10, 16 p., 269.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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7 Citations (Scopus)

Chronic sympathetic driven hypertension promotes atherosclerosis by enhancing hematopoiesis

Al-Sharea, A., Lee, M. K. S., Whillas, A., Michell, D. L., Shihata, W. A., Nicholls, A. J., Cooney, O. D., Kraakman, M. J., Veiga, C. B., Jefferis, A. M., Jackson, K., Nagareddy, P. R., Lambert, G., Wong, C. H. Y., Andrews, K. L., Head, G. A., Chin-Dusting, J. & Murphy, A. J., 28 Feb 2019, In : Haematologica: the hematology journal. 104, 3, p. 456-467 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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7 Citations (Scopus)

D. Russelii venom mediates vasodilatation of resistance like arteries via activation of k v and k ca channels

Kakumanu, R., Kuruppu, S., Rash, L. D., Isbister, G. K., Hodgson, W. C. & Kemp-Harper, B. K., 1 Apr 2019, In : Toxins. 11, 4, 10 p., 197.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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1 Citation (Scopus)

Distinct Redox Signalling following Macrophage Activation Influences Profibrotic Activity

Lewis, C. V., Vinh, A., Diep, H., Samuel, C. S., Drummond, G. R. & Kemp-Harper, B. K., 11 Nov 2019, In : Journal of Immunology Research. 2019, 15 p., 1278301.

Research output: Contribution to journalArticleResearchpeer-review

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Drug-receptor kinetics and sigma-1 receptor affinity differentiate clinically evaluated histamine H3 receptor antagonists

Riddy, D. M., Cook, A. E., Shackleford, D. M., Pierce, T. L., Mocaer, E., Mannoury la Cour, C., Sors, A., Charman, W. N., Summers, R. J., Sexton, P. M., Christopoulos, A. & Langmead, C. J., 1 Jan 2019, In : Neuropharmacology. 144, p. 244-255 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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6 Citations (Scopus)

Dysregulation of the placental renin–angiotensin system in human fetal growth restriction

Delforce, S. J., Lumbers, E. R., Ellery, S. J., Murthi, P. & Pringle, K. G., Sep 2019, In : Reproduction. 158, 3, p. 237-245 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Effects of high- and low-dose aspirin on adaptive immunity and hypertension in the stroke-prone spontaneously hypertensive rat

Khan, S. I., Shihata, W. A., Andrews, K. L., Lee, M. K. S., Moore, X-L., Jefferis, A-M., Vinh, A., Gaspari, T., Dragoljevic, D., Jennings, G. L., Murphy, A. J. & Chin-Dusting, J. P. F., 1 Jan 2019, In : The FASEB Journal. 33, 1, p. 1510-1521 12 p.

Research output: Contribution to journalArticleResearchpeer-review

4 Citations (Scopus)

Expression and activity of the calcitonin receptor family in a sample of primary human high-grade gliomas

Ostrovskaya, A., Hick, C., Hutchinson, D. S., Stringer, B. W., Wookey, P. J., Wootten, D., Sexton, P. M. & Furness, S. G. B., 18 Feb 2019, In : BMC Cancer. 19, 1, 12 p., 157.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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1 Citation (Scopus)

Glycine microparticles loaded with functionalized nanoparticles for pulmonary delivery

Chakraborty, A., Royce, S. G., Plebanski, M. & Selomulya, C., 30 Oct 2019, In : International Journal of Pharmaceutics. 570, 9 p., 118654.

Research output: Contribution to journalArticleResearchpeer-review

1 Citation (Scopus)

G-Protein–Coupled Receptors Are Dynamic Regulators of Digestion and Targets for Digestive Diseases

Canals, M., Poole, D. P., Veldhuis, N. A., Schmidt, B. L. & Bunnett, N. W., 1 May 2019, In : Gastroenterology. 156, 6, p. 1600-1616 17 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

3 Citations (Scopus)

GRK mediates µ-opioid receptor plasma membrane reorganization

Gondin, A. B., Halls, M. L., Canals, M. & Briddon, S. J., 1 May 2019, In : Frontiers in Molecular Neuroscience. 12, 14 p., 104.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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3 Citations (Scopus)

Human amnion epithelial cells and their soluble factors reduce liver fibrosis in murine non-alcoholic steatohepatitis

Kuk, N., Hodge, A., Sun, Y., Correia, J., Alhomrani, M., Samuel, C., Moore, G., Lim, R. & Sievert, W., Aug 2019, In : Journal of Gastroenterology and Hepatology. 34, 8, p. 1441-1449 9 p.

Research output: Contribution to journalArticleResearchpeer-review

3 Citations (Scopus)

IL-37 increases in patients after ischemic stroke and protects from inflammatory brain injury, motor impairment and lung infection in mice

Zhang, S. R., Nold, M. F., Tang, S. C., Bui, C. B., Nold, C. A., Arumugam, T. V., Drummond, G. R., Sobey, C. G. & Kim, H. A., 1 Dec 2019, In : Scientific Reports. 9, 1, 12 p., 6922.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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5 Citations (Scopus)

Inflammasomes: a novel therapeutic target in pulmonary hypertension?

Scott, T. E., Kemp-Harper, B. K. & Hobbs, A. J., 1 Jun 2019, In : British Journal of Pharmacology. 176, 12, p. 1880-1896 17 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

6 Citations (Scopus)

Interleukin-1 receptor antagonist protects newborn mice against pulmonary hypertension

Bui, C. B., Kolodziej, M., Lamanna, E., Elgass, K., Sehgal, A., Rudloff, I., Schwenke, D. O., Tsuchimochi, H., Kroon, M. A. G. M., Cho, S. X., Maksimenko, A., Cholewa, M., Berger, P. J., Young, M. J., Bourke, J. E., Pearson, J. T., Nold, M. F. & Nold-Petry, C. A., 11 Jul 2019, In : Frontiers in Immunology. 10, JULY, 15 p., 1480.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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2 Citations (Scopus)
1 Citation (Scopus)

Kinetic and system bias as drivers of metabotropic glutamate receptor 5 allosteric modulator pharmacology

Sengmany, K., Hellyer, S. D., Albold, S., Wang, T., Conn, P. J., May, L. T., Christopoulos, A., Leach, K. & Gregory, K. J., 1 May 2019, In : Neuropharmacology. 149, p. 83-96 14 p.

Research output: Contribution to journalArticleResearchpeer-review

5 Citations (Scopus)

Light-activated chimeric GPCRs: limitations and opportunities

Tichy, A-M., Gerrard, E. J., Sexton, P. M. & Janovjak, H., 1 Aug 2019, In : Current Opinion in Structural Biology. 57, p. 196-203 8 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

Localised GPCR signalling as revealed by FRET biosensors

Halls, M. L., 1 Apr 2019, In : Current Opinion in Cell Biology. 57, p. 48-56 9 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

5 Citations (Scopus)