Research Output 1986 2020

2020

Assays for Measuring the Role of MIF in NLRP3 Inflammasome Activation

Pinar, A. A. & Harris, J., 2020, Macrophage Migration Inhibitory Factor: Methods and Protocols. Harris, J. & Morand, E. F. (eds.). New York, NY: Humana Press, Vol. 2080. p. 159-172 14 p. (Methods in Molecular Biology).

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Otherpeer-review

2019

6-Phenylpyrimidin-4-ones as Positive Allosteric Modulators at the M1 mAChR: The Determinants of Allosteric Activity

Jorg, M. T., van der Westhuizen, E. T., Khajehali, E., Burger, W. A. C., White, J., Choy, K. H. C., Tobin, A. B., Sexton, P. M., Valant, C., Capuano, B., Christopoulos, A. & Scammells, P. J., 20 Mar 2019, In : ACS Chemical Neuroscience. 10, 3, p. 1099-1114 16 p.

Research output: Contribution to journalArticleResearchpeer-review

1 Citation (Scopus)

Adrenoceptor regulation of the mechanistic target of rapamycin in muscle and adipose tissue

Chia, L. Y., Evans, B., Mukaida, S., Bengtsson, T., Hutchinson, D. & Sato, M., 1 Jul 2019, In : British Journal of Pharmacology. 176, 14, p. 2433-2448 16 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

Open Access
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2 Citations (Scopus)

A ligand-induced structural change in fatty acid-binding protein 1 is associated with potentiation of peroxisome proliferator-activated receptor α agonists

Patil, R., Mohanty, B., Liu, B., Chandrashekaran, I. R., Headey, S. J., Williams, M. L., Clements, C. S., Ilyichova, O., Doak, B. C., Genissel, P., Weaver, R., Vuillard, L., Halls, M. L., Porter, C. J. H. & Scanlon, M. J., 8 Mar 2019, In : Journal of Biological Chemistry. 294, 10, p. 3720-3734 15 p.

Research output: Contribution to journalArticleResearchpeer-review

A New Pathway to Airway Relaxation - Targeting the "Other" Cyclase in Asthma

Lam, M. & Bourke, J. E., 2019, (Accepted/In press) In : American Journal of Respiratory Cell and Molecular Biology.

Research output: Contribution to journalEditorialOtherpeer-review

Open Access
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A Series of Analogues to the AT 2 R Prototype Antagonist C38 Allow Fine Tuning of the Previously Reported Antagonist Binding Mode

Isaksson, R., Lindman, J., Wannberg, J., Sallander, J., Backlund, M., Baraldi, D., Widdop, R., Hallberg, M., Åqvist, J., Gutierrez de Teran, H., Gising, J. & Larhed, M., 1 Jan 2019, In : ChemistryOpen. 8, 1, p. 114-125 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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AT1R-AT2R-RXFP1 functional crosstalk in myofibroblasts: Impact on the therapeutic targeting of renal and cardiac fibrosis

Chow, B. S. M., Kocan, M., Shen, M., Wang, Y., Han, L., Chew, J. Y., Wang, C., Bosnyak, S., Mirabito-Colafella, K. M., Barsha, G., Wigg, B., Johnstone, E. K. M., Hossain, M. A., Pfleger, K. D. G., Denton, K. M., Widdop, R. E., Summers, R. J., Bathgate, R. A. D., Hewitson, T. D. & Samuel, C. S., 1 Jan 2019, In : Journal of the American Society of Nephrology. 30, 11, p. 2191-2207 17 p.

Research output: Contribution to journalArticleResearchpeer-review

2 Citations (Scopus)

A Thieno[2,3-d]pyrimidine Scaffold is a Novel Negative Allosteric Modulator of the Dopamine D2 Receptor

Fyfe, T. J., Zarzycka, B., Lim, H. D., Kellam, B., Mistry, S. N., Katrich, V., Scammells, P. J., Lane, J. R. & Capuano, B., 1 Oct 2019, In : Journal of Medicinal Chemistry. 62, 1, p. 174-206 33 p.

Research output: Contribution to journalArticleResearchpeer-review

Atypical cannabinoid ligands O-1602 and O-1918 administered chronically in diet-induced obesity

Simcocks, A. C., Jenkin, K. A., O’Keefe, L., Samuel, C. S., Mathai, M. L., McAinch, A. J. & Hryciw, D. H., Mar 2019, In : Endocrine Connections. 8, 3, p. 203-216 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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1 Citation (Scopus)

BRL37344 stimulates GLUT4 translocation and glucose uptake in skeletal muscle via β 2 -adrenoceptors without causing classical receptor desensitization

Mukaida, S., Sato, M., Öberg, A. I., Dehvari, N., Olsen, J. M., Kocan, M., Halls, M. L., Merlin, J., Sandström, A. L., Csikasz, R. I., Evans, B. A., Summers, R. J., Hutchinson, D. S. & Bengtsson, T., 1 May 2019, In : American journal of physiology. Regulatory, integrative and comparative physiology. 316, 5, p. R666-R677 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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3 Citations (Scopus)

Cardioprotective actions of the annexin-A1 N-terminal peptide, AC2-26, against myocardial infarction

Qin, C. X., Rosli, S., Deo, M., Cao, N., Walsh, J., Tate, M., Alexander, A. E., Donner, D., Horlock, D., Li, R., Kiriazis, H., Lee, M. K. S., Bourke, J. E., Yang, Y., Murphy, A. J., Du, X-J., Gao, X. M. & Ritchie, R. H., 3 Apr 2019, In : Frontiers in Pharmacology. 10, 16 p., 269.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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5 Citations (Scopus)

Chronic sympathetic driven hypertension promotes atherosclerosis by enhancing hematopoiesis

Al-Sharea, A., Lee, M. K. S., Whillas, A., Michell, D. L., Shihata, W. A., Nicholls, A. J., Cooney, O. D., Kraakman, M. J., Veiga, C. B., Jefferis, A. M., Jackson, K., Nagareddy, P. R., Lambert, G., Wong, C. H. Y., Andrews, K. L., Head, G. A., Chin-Dusting, J. & Murphy, A. J., 28 Feb 2019, In : Haematologica: the hematology journal. 104, 3, p. 456-467 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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D. Russelii venom mediates vasodilatation of resistance like arteries via activation of k v and k ca channels

Kakumanu, R., Kuruppu, S., Rash, L. D., Isbister, G. K., Hodgson, W. C. & Kemp-Harper, B. K., 1 Apr 2019, In : Toxins. 11, 4, 10 p., 197.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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4 Citations (Scopus)

Drug-receptor kinetics and sigma-1 receptor affinity differentiate clinically evaluated histamine H3 receptor antagonists

Riddy, D. M., Cook, A. E., Shackleford, D. M., Pierce, T. L., Mocaer, E., Mannoury la Cour, C., Sors, A., Charman, W. N., Summers, R. J., Sexton, P. M., Christopoulos, A. & Langmead, C. J., 1 Jan 2019, In : Neuropharmacology. 144, p. 244-255 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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3 Citations (Scopus)

Effects of high- and low-dose aspirin on adaptive immunity and hypertension in the stroke-prone spontaneously hypertensive rat

Khan, S. I., Shihata, W. A., Andrews, K. L., Lee, M. K. S., Moore, X-L., Jefferis, A-M., Vinh, A., Gaspari, T., Dragoljevic, D., Jennings, G. L., Murphy, A. J. & Chin-Dusting, J. P. F., 1 Jan 2019, In : FASEB Journal. 33, 1, p. 1510-1521 12 p.

Research output: Contribution to journalArticleResearchpeer-review

1 Citation (Scopus)

Expression and activity of the calcitonin receptor family in a sample of primary human high-grade gliomas

Ostrovskaya, A., Hick, C., Hutchinson, D. S., Stringer, B. W., Wookey, P. J., Wootten, D., Sexton, P. M. & Furness, S. G. B., 18 Feb 2019, In : BMC Cancer. 19, 1, 12 p., 157.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Glycine microparticles loaded with functionalized nanoparticles for pulmonary delivery

Chakraborty, A., Royce, S. G., Plebanski, M. & Selomulya, C., 30 Oct 2019, In : International Journal of Pharmaceutics. 570, 9 p., 118654.

Research output: Contribution to journalArticleResearchpeer-review

G-Protein–Coupled Receptors Are Dynamic Regulators of Digestion and Targets for Digestive Diseases

Canals, M., Poole, D. P., Veldhuis, N. A., Schmidt, B. L. & Bunnett, N. W., 1 May 2019, In : Gastroenterology. 156, 6, p. 1600-1616 17 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

1 Citation (Scopus)

GRK mediates µ-opioid receptor plasma membrane reorganization

Gondin, A. B., Halls, M. L., Canals, M. & Briddon, S. J., 1 May 2019, In : Frontiers in Molecular Neuroscience. 12, 14 p., 104.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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2 Citations (Scopus)

Human amnion epithelial cells and their soluble factors reduce liver fibrosis in murine non-alcoholic steatohepatitis

Kuk, N., Hodge, A., Sun, Y., Correia, J., Alhomrani, M., Samuel, C., Moore, G., Lim, R. & Sievert, W., Aug 2019, In : Journal of Gastroenterology and Hepatology. 34, 8, p. 1441-1449 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Identification of monellin as the first naturally derived proteinaceous allosteric agonist of metabotropic glutamate receptor 5

Chen, A. N. Y., Hellyer, S. D., Trinh, P. N. H., Leach, K. & Gregory, K. J., 14 Apr 2019, (Accepted/In press) In : Basic and Clinical Pharmacology and Toxicology. 22 p.

Research output: Contribution to journalArticleResearchpeer-review

3 Citations (Scopus)

IL-37 increases in patients after ischemic stroke and protects from inflammatory brain injury, motor impairment and lung infection in mice

Zhang, S. R., Nold, M. F., Tang, S. C., Bui, C. B., Nold, C. A., Arumugam, T. V., Drummond, G. R., Sobey, C. G. & Kim, H. A., 1 Dec 2019, In : Scientific Reports. 9, 1, 12 p., 6922.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Interleukin-1 receptor antagonist protects newborn mice against pulmonary hypertension

Bui, C. B., Kolodziej, M., Lamanna, E., Elgass, K., Sehgal, A., Rudloff, I., Schwenke, D. O., Tsuchimochi, H., Kroon, M. A. G. M., Cho, S. X., Maksimenko, A., Cholewa, M., Berger, P. J., Young, M. J., Bourke, J. E., Pearson, J. T., Nold, M. F. & Nold-Petry, C. A., 11 Jul 2019, In : Frontiers in Immunology. 10, JULY, 15 p., 1480.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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2 Citations (Scopus)

Kinetic and system bias as drivers of metabotropic glutamate receptor 5 allosteric modulator pharmacology

Sengmany, K., Hellyer, S. D., Albold, S., Wang, T., Conn, P. J., May, L. T., Christopoulos, A., Leach, K. & Gregory, K. J., 1 May 2019, In : Neuropharmacology. 149, p. 83-96 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Light-activated chimeric GPCRs: limitations and opportunities

Tichy, A-M., Gerrard, E. J., Sexton, P. M. & Janovjak, H., 1 Aug 2019, In : Current Opinion in Structural Biology. 57, p. 196-203 8 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

2 Citations (Scopus)

Localised GPCR signalling as revealed by FRET biosensors

Halls, M. L., 1 Apr 2019, In : Current Opinion in Cell Biology. 57, p. 48-56 9 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

Molecular Basis of Action of a Small-Molecule Positive Allosteric Modulator Agonist at the Type 1 Cholecystokinin Holoreceptor

Desai, A. J., Mechin, I., Nagarajan, K., Valant, C., Wootten, D., Lam, P. C. H., Orry, A., Abagyan, R., Nair, A., Sexton, P. M., Christopoulos, A. & Miller, L. J., 1 Mar 2019, In : Molecular Pharmacology. 95, 3, p. 245-259 15 p.

Research output: Contribution to journalArticleResearchpeer-review

2 Citations (Scopus)

NOx in exhaled breath condensate is related to allergic sensitization in young and middle-aged adults

Aldakheel, F. M., Bourke, J. E., Thomas, P. S., Matheson, M. C., Abramson, M. J., Hamilton, G. S., Lodge, C. J., Thompson, B. R., Haydn Walters, E., Allen, K. J., Erbas, B., Perret, J. L., Dharmage, S. C. & Lowe, A. J., Feb 2019, In : Clinical and Experimental Allergy. 49, 2, p. 171-179 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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10 Citations (Scopus)

Pharmacological inhibition of the NLRP3 inflammasome reduces blood pressure, renal damage, and dysfunction in salt-sensitive hypertension

Krishnan, S. M., Ling, Y. H., Huuskes, B. M., Ferens, D. M., Saini, N., Chan, C. T., Diep, H., Kett, M. M., Samuel, C. S., Kemp-Harper, B. K., Robertson, A. A. B., Cooper, M. A., Peter, K., Latz, E., Mansell, A. S., Sobey, C. G., Drummond, G. R. & Vinh, A., 15 Mar 2019, In : Cardiovascular Research. 115, 4, p. 776-787 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Profiling histone modifications in the normal mouse kidney and after unilateral ureteric obstruction

Hewitson, T. D., Holt, S. G., Samuel, C. S., Wigg, B. & Smith, E. R., 1 Sep 2019, In : American journal of physiology. Renal physiology. 317, 3, p. F606-F615 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Regulation of Airway Smooth Muscle Contraction in Health and Disease

Lam, M., Lamanna, E. & Bourke, J. E., 24 Jun 2019, Smooth Muscle Spontaneous Activity: Physiological and Pathological Modulation. Hashitani, H. & Lang, R. J. (eds.). Singapore: Springer, p. 381-422 42 p. (Advances in Experimental Medicine and Biology; vol. 1124).

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Otherpeer-review

1 Citation (Scopus)

Relaxin and extracellular matrix remodeling: Mechanisms and signaling pathways

Ng, H. H., Shen, M., Samuel, C. S., Schlossmann, J. & Bennett, R. G., 1 May 2019, In : Molecular and Cellular Endocrinology. 487, p. 59-65 7 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

Relaxin and fibrosis: Emerging targets, challenges, and future directions

Kanai, A. J., Konieczko, E. M., Bennett, R. G., Samuel, C. S. & Royce, S. G., 1 May 2019, In : Molecular and Cellular Endocrinology. 487, p. 66-74 9 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

Self-assembling injectable peptide hydrogels for emerging treatment of ischemic stroke

Hong, A., Aguilar, M-I., Del Borgo, M. P., Sobey, C. G., Broughton, B. R. S. & Forsythe, J. S., 2019, In : Journal of Materials Chemistry B. 7, 25, p. 3927-3943 17 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

Serelaxin enhances the therapeutic effects of human amnion epithelial cell-derived exosomes in experimental models of lung disease

Royce, S. G., Patel, K. P., Mao, W., Zhu, D., Lim, R. & Samuel, C. S., Jul 2019, In : British Journal of Pharmacology. 176, 13, p. 2195-2208 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Serelaxin inhibits the profibrotic TGF-β1/IL-1β axis by targeting TLR-4 and the NLRP3 inflammasome in cardiac myofibroblasts

Tapia Caceres, F., Gaspari, T. A., Samuel, C. S. & Pinar, A. A., Dec 2019, In : FASEB Journal. 33, 12, p. 14717-14733 17 p.

Research output: Contribution to journalArticleResearchpeer-review

1 Citation (Scopus)

Signalling in response to sub-picomolar concentrations of active compounds: Pushing the boundaries of GPCR sensitivity

Civciristov, S. & Halls, M. L., Jul 2019, In : British Journal of Pharmacology. 176, 14, p. 2382-2401 20 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

Subtle modifications to a thieno[2,3-d]pyrimidine scaffold yield negative allosteric modulators and agonists of the dopamine D 2 receptor

Fyfe, T. J., Kellam, B., Mistry, S. N., Scammells, P. J., Lane, J. R. & Capuano, B., 15 Apr 2019, In : European Journal of Medicinal Chemistry. 168, p. 474-490 17 p.

Research output: Contribution to journalArticleResearchpeer-review

2 Citations (Scopus)

The adenosine A 2B G protein-coupled receptor: Recent advances and therapeutic implications

Vecchio, E. A., White, P. J. & May, L. T., 1 Jan 2019, In : Pharmacology and Therapeutics. 198, p. 20-33 14 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

5 Citations (Scopus)

The gut microbiota and blood pressure in experimental models

Jama, H. A., Kaye, D. M. & Marques, F. Z., 1 Mar 2019, In : Current Opinion in Nephrology and Hypertension. 28, 2, p. 97-104 8 p.

Research output: Contribution to journalArticleResearchpeer-review

The Molecular Control of Calcitonin Receptor Signaling

dal Maso, E., Glukhova, A., Zhu, Y., Garcia-Nafria, J., Tate, C. G., Atanasio, S., Reynolds, C. A., Ramirez-Aportela, E., Carazo, J-M., Hick, C. A., Furness, S. G. B., Hay, D. L., Liang, Y-L., Miller, L. J., Christopoulos, A., Wang, M-W., Wootten, D. & Sexton, P. M., 11 Jan 2019, In : ACS Pharmacology and Translational Sciences. 2, 1, p. 31-51 21 p.

Research output: Contribution to journalArticleResearchpeer-review

The use of live cell imaging and automated image analysis to assist with determining optimal parameters for angiogenic assay in vitro

Huuskes, B. M., DeBuque, R. J., Kerr, P. G., Samuel, C. S. & Ricardo, S. D., 10 Apr 2019, In : Frontiers in Cell and Developmental Biology. 7, 14 p., 45.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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1 Citation (Scopus)

Understanding relaxin signalling at the cellular level

Valkovic, A. L., Bathgate, R. AD., Samuel, C. S. & Kocan, M., 1 May 2019, In : Molecular and Cellular Endocrinology. 487, p. 24-33 10 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

1 Citation (Scopus)

Vampire venom: Vasodilatory mechanisms of vampire bat (desmodus rotundus) blood feeding

Kakumanu, R., Hodgson, W. C., Ravi, R., Alagon, A., Harris, R. J., Brust, A., Alewood, P. F., Kemp-Harper, B. K. & Fry, B. G., 8 Jan 2019, In : Toxins. 11, 1, 10 p., 26.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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2018
10 Citations (Scopus)

Acute or Delayed Systemic Administration of Human Amnion Epithelial Cells Improves Outcomes in Experimental Stroke

Evans, M. A., Lim, R., Kim, H. A., Chu, H. X., Gardiner-Mann, C. V., Taylor, K. W. E., Chan, C. T., Brait, V. H., Lee, S., Dinh, Q. N., Vinh, A., Phan, T. G., Srikanth, V. K., Ma, H., Arumugam, T. V., Fann, D. Y., Poh, L., Hunt, C. P. J., Pouton, C. W., Haynes, J. M. & 12 others, Selemidis, S., Kwan, W., Teo, L., Bourne, J. A., Neumann, S., Young, S., Gowing, E. K., Drummond, G. R., Clarkson, A. N., Wallace, E. M., Sobey, C. G. & Broughton, B. R. S., 1 Mar 2018, In : Stroke. 49, 3, p. 700-709 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Age-related differential structural and transcriptomic responses in the hypertensive heart

Marques, F. Z., Chu, P. Y., Ziemann, M., Kaspi, A., Kiriazis, H., Du, X. J., El-Osta, A. & Kaye, D. M., 9 Jul 2018, In : Frontiers in Physiology. 9, JUL, 13 p., 817.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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3 Citations (Scopus)

Amnion epithelial cells - A novel therapy for ischemic stroke?

Evans, M. A., Broughton, B. R. S., Drummond, G. R., Ma, H., Phan, T. G., Wallace, E. M., Lim, R. & Sobey, C. G., 1 Aug 2018, In : Neural Regeneration Research. 13, 8, p. 1346-1349 4 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

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3 Citations (Scopus)

A polymorphism in the noradrenaline transporter gene is associated with increased blood pressure in patients with resistant hypertension

Eikelis, N., Marques, F. Z., Hering, D., Marusic, P., Head, G. A., Walton, A. S., Lambert, E. A., Esler, M. D., Sari, C. I., Schlaich, M. P. & Lambert, G. W., 1 Jul 2018, In : Journal of Hypertension. 36, 7, p. 1571-1577 7 p.

Research output: Contribution to journalArticleResearchpeer-review