Research Output 1995 2018

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2018

Effect of the 5-HT4 receptor agonist tegaserod on the expression of GRK2 and GRK6 in the rat gastrointestinal tract

Nedi, T., White, P. J., Coupar, I. M. & Irving, H. R., 8 Jun 2018, In : BMC Research Notes. 11, 1, 6 p., 362.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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2013
2 Citations (Scopus)

Applicability of green fluorescence protein in the study of endothelin converting enzyme-1c trafficking

Kuruppu, DM. S., Tochon-Danguy, N. & Smith, A. I., 2013, In : Protein Science. 22, 3, p. 306 - 313 8 p.

Research output: Contribution to journalArticleResearchpeer-review

17 Citations (Scopus)

Bioluminescent orthotopic model of pancreatic cancer progression

Chai, M. G., Kim-Fuchs, C., Angst, E. & Sloan, E. K., 1 Jun 2013, In : Journal of Visualized Experiments. 2013, 76, e50395.

Research output: Contribution to journalArticleResearchpeer-review

2012
3 Citations (Scopus)

Assessment of the pharmacological properties of 5-methoxyindole derivatives at 5-HT4 receptors

Coupar, I. M., Irving, H. R., Manallack, D. T., Tan, Y. Y., Ayad, F., Di Iulio, J. L., Tochon-Danguy, N. & Iskander, M. N., 2012, In : Journal of Pharmacy and Pharmacology. 64, 8, p. 1099 - 1106 8 p.

Research output: Contribution to journalArticleResearchpeer-review

22 Citations (Scopus)

A two-hit model: behavioural investigation of the effect of combined neonatal MK-801 administration and isolation rearing in the rat

Lim, A. L., Taylor, D. & Malone, D. T., 2012, In : Journal of Psychopharmacology. 26, 9, p. 1252 - 1264 13 p.

Research output: Contribution to journalArticleResearchpeer-review

32 Citations (Scopus)

Cannabidiol and clozapine reverse MK-801-induced deficits in social interaction and hyperactivity in Sprague-Dawley rats

Gururajan, A., Taylor, D. & Malone, D. T., 2012, In : Journal of Psychopharmacology. 26, 10, p. 1317 - 1332 16 p.

Research output: Contribution to journalArticleResearchpeer-review

62 Citations (Scopus)

Chronic stress enhances progression of acute lymphoblastic leukemia via beta-adrenergic signaling

Lamkin, D. M., Sloan, E. K., Patel, A. J., Chiang, B. S., Pimentel, M. A., Ma, J. C. Y., Arevalo, J. MG., Morizono, K. & Cole, S. W., 2012, In : Brain, Behavior, and Immunity. 26, 4, p. 635 - 641 7 p.

Research output: Contribution to journalArticleResearchpeer-review

2 Citations (Scopus)

Colloidal characteristics and formulation of pure protein particulate vaccines

White, P. J., Hickey, P. LC., Tu, L. S., Headey, S. J., Scanlon, M., Boyd, B. J. & Pouton, C. W., 2012, In : Journal of Pharmacy and Pharmacology. 64, 10, p. 1386 - 1393 8 p.

Research output: Contribution to journalArticleResearchpeer-review

41 Citations (Scopus)

Consequences of early life MK-801 administration: Long-term behavioural effects and relevance to schizophrenia research

Lim, A. L., Taylor, D. & Malone, D. T., 2012, In : Behavioural Brain Research. 227, 1, p. 276 - 286 11 p.

Research output: Contribution to journalArticleResearchpeer-review

29 Citations (Scopus)

Enhanced extravasation, stability and in vivo cardiac gene silencing via in situ siRNA-albumin conjugation

Lau, S., Graham, B., Cao, N., Boyd, B. J., Pouton, C. W. & White, P. J., 2012, In : Molecular Pharmaceutics. 9, 1, p. 71 - 80 10 p.

Research output: Contribution to journalArticleResearchpeer-review

9 Citations (Scopus)

Enhanced lithium-induced brain recovery following cranial irradiation is not impeded by inflammation

Malaterre, J., McPherson, C., Denoyer, D., Lai, E., Hagekyriakou, J., Lightowler, S., Shudo, K., Ernst, M. R., Ashley, D. M., Short, J. L., Wheeler, G. & Ramsay, R. G., 2012, In : Stem Cells Translational Medicine. 1, 6, p. 469 - 479 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
37 Citations (Scopus)

Identification and profiling of novel alpha 1(A)-adrenoceptor-CXC chemokine receptor 2 heteromer

Mustafa, S., See, H. B., Seeber, R., Armstrong, S. P., White, C., Ventura, S., Ayoub, M. A. & Pfleger, K., 2012, In : Journal of Biological Chemistry. 287, 16, p. 12952 - 12965 14 p.

Research output: Contribution to journalArticleResearchpeer-review

20 Citations (Scopus)

Investigation of the neuroanatomical substrates of reward seeking following protracted abstinence in mice

Madsen, H. B., Brown, R. M., Short, J. L. & Lawrence, A. J., 2012, In : The Journal of Physiology. 590, 10, p. 2427 - 2442 16 p.

Research output: Contribution to journalArticleResearchpeer-review

24 Citations (Scopus)

In vitro maturation of dopaminergic neurons derived from mouse embryonic stem cells: Implications for transplantation

Watmuff, B., Pouton, C. W. & Haynes, J. M., 2012, In : PLoS ONE. 7, 2, 11 p., e31999.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
6 Citations (Scopus)

K/BxN serum transfer arthritis is delayed and less severe in leukaemia inhibitory factor (LIF)-deficient mice

Upadhyay, A., Senyschyn, D., Santos, L. L., Gu, R., Carroll, G. J. & Jazayeri, J., 2012, In : Clinical and Experimental Immunology. 169, 2, p. 71 - 78 8 p.

Research output: Contribution to journalArticleResearchpeer-review

85 Citations (Scopus)

Lipid digestion as a trigger for supersaturation: evaluation of the impact of supersaturation stabilization on the in vitro and in vivo performance of self-emulsifying drug delivery systems

Anby, M. U., Williams, H. D., McIntosh, M. P., Benameur, H., Edwards, G. A., Pouton, C. W. & Porter, C. J., 2012, In : Molecular Pharmaceutics. 9, 9, p. 2063 - 2079 17 p.

Research output: Contribution to journalArticleResearchpeer-review

15 Citations (Scopus)

Lmx1a allows context-specific isolation of progenitors of GABAergic or dopaminergic neurons during neural differentiation of embryonic stem cells

Nefzger, C., Su, C. T. E., Fabb, S. A., Hartley, B. J., Zeng, W., Haynes, J. M. & Pouton, C. W., 2012, In : Stem Cells. 30, 7, p. 1349 - 1361 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Moonlighting kinases with guanylate cyclase activity can tune regulatory signal networks

Irving, H. R., Kwezi, L., Wheeler, J. & Gehring, C. A., Feb 2012, In : Plant Signaling and Behavior. 7, 2, p. 201-204 4 p.

Research output: Contribution to journalArticleResearchpeer-review

11 Citations (Scopus)

Nitric oxide signaling pathways involved in the inhibition of spontaneous activity in the guinea pig prostate

Dey, A., Lang, R. J. & Exintaris, B., 2012, In : Journal of Urology. 187, 6, p. 2254 - 2260 7 p.

Research output: Contribution to journalArticleResearchpeer-review

171 Citations (Scopus)

Primary tumor hypoxia recruits CD11b+/Ly6Cmed/Ly6G+ immune suppressor cells and compromises NK cell cytotoxicity in the premetastatic niche

Sceneay, J., Chow, M., Chen, A., Halse, H., Wong, C. S. F., Andrews, D. M., Sloan, E. K., Parker, B., Bowtell, D. DL., Smyth, M. & Moller, A., 2012, In : Cancer Research. 72, 16, p. 3906 - 3911 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
6 Citations (Scopus)

Protein Kinase C recognition sites in the cytoplasmic domain of Endothelin Converting Enzyme-1c

Kuruppu, DM. S., Tochon-Danguy, N. & Smith, A. I., 2012, In : Biochemical and Biophysical Research Communications. 427, 3, p. 606 - 610 5 p.

Research output: Contribution to journalArticleResearchpeer-review

4 Citations (Scopus)

Synthesis and biological evaluation of adenosines with heterobicyclic and polycyclic N6-substituents as adenosine A1 receptor agonists

Gosling, J. I., Baker, S. P., Haynes, J. M., Kassiou, M., Pouton, C. W., Warfe, L., White, P. J. & Scammells, P. J., 2012, In : ChemMedChem. 7, 7, p. 1191 - 1201 11 p.

Research output: Contribution to journalArticleResearchpeer-review

23 Citations (Scopus)

Synthesis and biological evaluation of N-substituted noscapine analogues

Debono, A. J., Xie, J. H., Ventura, S., Pouton, C. W., Capuano, B. & Scammells, P. J., 2012, In : ChemMedChem. 7, 12, p. 2122 - 2133 12 p.

Research output: Contribution to journalArticleResearchpeer-review

14 Citations (Scopus)

Synthesis and pharmacological evaluation of dual acting antioxidant A2A adenosine receptor agonists

Hausler, N., Devine, S., McRobb, F. M., Warfe, L., Pouton, C. W., Haynes, J. M., Bottle, S. E., White, P. J. & Scammells, P. J., 2012, In : Journal of Medicinal Chemistry. 55, 7, p. 3521 - 3534 14 p.

Research output: Contribution to journalArticleResearchpeer-review

8 Citations (Scopus)

The effect of folinic acid on methylenetetrahydrofolate reductase polymorphisms in methotrexate-treated allogeneic hematopoietic stem cell transplants

Murphy, N., Diviney, M., Szer, J., Bardy, P., Grigg, A. P., Hoyt, R., King-Kallimanis, B. L., Holdsworth, R., McCluskey, J. & Tait, B. D., 2012, In : Biology of Blood and Marrow Transplantation. 18, 5, p. 722 - 730 9 p.

Research output: Contribution to journalArticleResearchpeer-review

8 Citations (Scopus)
77 Citations (Scopus)

Toward the establishment of standardized in vitro tests for lipid-based formulations. 2. The effect of bile salt concentration and drug loading on the performance of type I, II, IIIA, IIIB, and IV formulations during in vitro digestion

Williams, H. D., Anby, M. U., Sassene, P. J., Kleberg, K., Bakala-N'Goma, J-C., Calderone, M., Jannin, V., Igonin, A., Partheil, A., Marchaud, D., Jule, E., Vertommen, J., Maio, M., Blundell, R., Benameur, H., Carriere, F., Mullertz, A., Pouton, C. W. & Porter, C. J., 2012, In : Molecular Pharmaceutics. 9, 11, p. 3286 - 3300 15 p.

Research output: Contribution to journalArticleResearchpeer-review

161 Citations (Scopus)

VEGF-D promotes tumor metastasis by regulating prostaglandins produced by the collecting lymphatic endothelium

Karnezis, T., Shayan, R., Caesar, C., Roufail, S., Harris, N. C., Ardipradja, K., Zhang, Y. F., Williams, S. P., Farnsworth, R. H., Chai, M. G., Rupasinghe, T. W. T., Tull, D., Baldwin, M. E., Sloan, E. K., Fox, S. B., Achen, M. G. & Stacker, S. A., 2012, In : Cancer Cell. 21, 2, p. 181 - 195 15 p.

Research output: Contribution to journalArticleResearchpeer-review

4 Citations (Scopus)

What makes the a 1A-adrenoceptor gene express the a 1L-adrenoceptor functional phenotype?

Ventura, S., 2012, In : British Journal of Pharmacology. 165, 5, p. 1223 - 1225 3 p.

Research output: Contribution to journalArticleOtherpeer-review

2011
73 Citations (Scopus)

A targeted NKX2.1 hesc reporter line enables identification of human basal forebrain derivatives

Goulburn, A., Alden, D., Davis, R. P., Micallef, S. J., Ng, E. S., Yu, Q. C., Lim, S. M., Soh, C-L., Elliott, D., Hatzistavrou, T., Bourke, J., Watmuff, B., Lang, R. J., Haynes, J. M., Pouton, C. W., Giudice, A., Trounson, A. O., Anderson, S. A., Stanley, E. & Elefanty, A., 2011, In : Stem Cells. 29, 3, p. 462 - 473 12 p.

Research output: Contribution to journalArticleResearchpeer-review

4 Citations (Scopus)

Commercially supplied amine-modified siRNAs may require ultrafiltration prior to conjugation with amine-reactive compounds

Lau, S., Graham, B., Boyd, B., Pouton, C. & White, P., 2011, In : Journal of Nucleic Acids. 2011, 154609, p. 1 - 5 5 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
12 Citations (Scopus)

Contractility and pacemaker cells in the prostate gland

Nguyen, D-T., Dey, A., Lang, R., Ventura, S. & Exintaris, B., 2011, In : Journal of Urology. 185, 1, p. 347 - 351 5 p.

Research output: Contribution to journalArticleResearchpeer-review

11 Citations (Scopus)

Contractions of the Mouse Prostate Elicited by Acetylcholine Are Mediated by M(3) Muscarinic Receptors

White, C., Short, J., Haynes, J., Matsui, M. & Ventura, S., 2011, In : Journal of Pharmacology and Experimental Therapeutics. 339, 3, p. 870 - 877 8 p.

Research output: Contribution to journalArticleResearchpeer-review

69 Citations (Scopus)

Developing a model of plant hormone interactions

Wang, Y. & Irving, H., 2011, In : Plant Signaling and Behavior. 6, 4, p. 494 - 500 7 p.

Research output: Contribution to journalArticleResearchpeer-review

17 Citations (Scopus)
21 Citations (Scopus)

Edaravone containing isoindoline nitroxides for the potential treatment of cardiovascular ischaemia

Walker, J., Fairfull-Smith, K., Anzai, K., Lau, S., White, P., Scammells, P. & Bottle, S. E., 2011, In : MedChemComm. 2, 5, p. 436 - 441 6 p.

Research output: Contribution to journalArticleResearchpeer-review

48 Citations (Scopus)

Effect of cannabidiol in a MK-801-rodent model of aspects of schizophrenia

Gururajan, A., Taylor, D. & Malone, D., 2011, In : Behavioural Brain Research. 222, 2, p. 299 - 308 10 p.

Research output: Contribution to journalArticleResearchpeer-review

4 Citations (Scopus)

Endothelin-1 and angiotensin II modulate rate and contraction amplitude in a subpopulation of mouse embryonic stem cell-derived cardiomyocyte-containing bodies

Lagerqvist, E. L., Finnin, B. A. L., Pouton, C. W. & Haynes, J. M., 2011, In : Stem Cell Research. 6, 1, p. 23 - 33 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
3 Citations (Scopus)

Ethanol extracts of saw palmetto contain the indirectly acting sympathomimetic: tyramine

Chua, T., Simpson, J. & Ventura, S., 2011, In : Prostate. 71, 1, p. 71 - 80 10 p.

Research output: Contribution to journalArticleResearchpeer-review

5 Citations (Scopus)
1 Citation (Scopus)
9 Citations (Scopus)

Heterogeneity amongst 5-HT3 receptor subunits: is this significant?

Yaakob, N., Malone, D., Exintaris, B. & Irving, H., 2011, In : Current Molecular Medicine. 11, 1, p. 57 - 88 32 p.

Research output: Contribution to journalArticleResearchpeer-review

8 Citations (Scopus)

Isolation rearing in rats: effect on expression of synaptic, myelin and GABA-related immunoreactivity and its utility for drug screening via Ne subchronic parenteral route

Lim, A., Taylor, D. & Malone, D., 2011, In : Brain Research. 1381, p. 52 - 65 14 p.

Research output: Contribution to journalArticleResearchpeer-review

34 Citations (Scopus)

Mechanism of microtubule-facilitated "fast track" nuclear import

Martino Roth, D., Moseley, G., Pouton, C. & Jans, D., 2011, In : Journal of Biological Chemistry. 286, 16, p. 14335 - 14351 17 p.

Research output: Contribution to journalArticleResearchpeer-review

8 Citations (Scopus)

Midbrain and forebrain patterning delivers immunocytochemically and functionally similar populations of neuropeptide Y containing GABAergic neurons

Khaira, S., Nefzger, C., Beh, S., Pouton, C. & Haynes, J., 2011, In : Neurochemistry International. 59, 3, p. 413 - 420 8 p.

Research output: Contribution to journalArticleResearchpeer-review

229 Citations (Scopus)

NKX2-5eGFP/w hESCs for isolation of human cardiac progenitors and cardiomyocytes

Elliott, D. A., Braam, S. R., Koutsis, K., S Ng, E., Jenny, R., Lagerqvist, E. L., Biben, C., Hatzistavrou, T., Hirst, C. E., Yu, Q. C., Skelton, R. JP., Ward-van Oostwaard, D., Lim, S. M., Khammy, O., Li, X., Hawes, S. M., Davis, R. P., Goulburn, A. L., Passier, R., Prall, O. WJ. & 6 others, Haynes, J. M., Pouton, C. W., Kaye, D. M., Mummery, C. L., Elefanty, A. G. & Stanley, E., 2011, In : Nature Methods. 8, 12, p. 1037 - 1040 4 p.

Research output: Contribution to journalArticleResearchpeer-review

45 Citations (Scopus)

Novel drug targets for the pharmacotherapy of benign prostatic hyperplasia (BPH)

Ventura, S., Oliver, V., White, C., Xie, A., Haynes, J. & Exintaris, B., 2011, In : British Journal of Pharmacology. 163, 5, p. 891 - 907 17 p.

Research output: Contribution to journalArticleResearchpeer-review

22 Citations (Scopus)

Plant natriuretic peptides are apoplastic and paracrine stress response molecules

Wang, Y., Gehring, C. A. & Irving, H., 2011, In : Plant and Cell Physiology. 52, 5 (SI), p. 837 - 850 14 p.

Research output: Contribution to journalArticleResearchpeer-review

61 Citations (Scopus)

Real time evolution of liquid crystalline nanostructure during the digestion of formulation lipids using synchrotron small-angle X-ray scattering

Warren, D., Anby, M., Hawley, A. & Boyd, B., 2011, In : Langmuir: the ACS journal of surfaces and colloids. 27, p. 9528 - 9534 7 p.

Research output: Contribution to journalArticleResearchpeer-review

19 Citations (Scopus)

Schizophrenia: a systematic review of the disease state, current therapeutics and their molecular mechanisms of action

Shin, J., Malone, D., Crosby, I. & Capuano, B., 2011, In : Current Medicinal Chemistry. 18, 9, p. 1380 - 1404 25 p.

Research output: Contribution to journalArticleResearchpeer-review