Monash Biomedicine Discovery Institute

Projects

Projects per year 2009 2019 2028

• 3 Not started
• 4 Curtailed
• 29 Active
• 182 Finished

Projects per year

Search results

• Active

  Exploiting a novel dendritic cell regulatory pathway for developing unique immunotherapies

  Lahoud, M. & Cryle, M.

  1/01/24 → 31/12/26

  Project: Research

• Bridging the gap between urinary tract infection pharmacokinetic/pharmacodynamic in vitro models and the optimization of antibiotic selection, dosing strategies, clinical breakpoints, and novel drug development

  Abbott, I., Peleg, A., Landersdorfer, C., Bradshaw, C., Meletiadis, J., Huttner, A. & Patel, R.

  United States Food and Drug Administration

  29/09/23 → 28/09/26

  Project: Research

• Resseptor Tx

  Ooi, J. & Purcell, A.

  5/04/23 → 30/11/24

  Project: Research

• Deconvoluting the complexity of lipid metabolism for prostate cancer therapy

  Taylor, R., Watt, M. & Pook, D.

  1/01/23 → 31/12/25

  Project: Research

• Investigations into phage biology directed at therapies for antimicrobial resistant (AMR) infections.

  Lithgow, T.

  1/01/23 → 31/12/27

  Project: Research

• Novel selective steroid prodrugs to improve survival of preterm babies and reduce abnormal postnatal brain development

  Cole, T., Wallace, M., De Franco, D. & Nichols-Monaghan, P.

  1/01/23 → 31/10/24

  Project: Research

• Development of a precision oncology program focused on a novel therapeutic target in triple negative breast cancer

  Daly, R., Chueh, A., Abud, H., Jarde, T., Loi, S., Tiganis, T., Swarbrick, A., Rosenbluh, S., Nguyen, L., Song, J. & Nekkalapudi, N.

  National Breast Cancer Foundation

  1/01/23 → 31/12/25

  Project: Research

• Targeting TGF-beta proteins to control animal reproduction

  Walton, K., Harrison, C., de Graaf, S. P. & Bernard, D. J.

  2/12/22 → 1/12/25

  Project: Research

• The Victorian Pre-clinical mRNA Innovation Incubator (VPMII)

  Porter, C., Pouton, C., Carroll, J., Beilharz, T., Purcell, D. F. J., Caruso, F., Trevaskis, N., Johnston, A., Davidovich, C. & Knott, G.

  23/06/22 → 22/06/25

  Project: Research

• PROPHECY: Profiling immune RespOnses in Paediatric and High risk populations to SARS-CoV-2

  McMahon, J., van Zelm, M., Khoury, G., Drummer, H., Mulley, W., Holland, A., Woolley, I., Ojaimi, S., Rogers, B., Hoi, A., Trauer, J., Sparrow, M., Licciardi, P. V., Giles, E., Curtis, D., Crawford, N., Leech, M., Westall, G., O'Hehir, R., Jones, A., Morand, E., Bosco, J. J. & Turner, S.

  Monash University, Alfred Health, Monash Health, Murdoch Children's Research Institute, Burnet Institute (Australia), Spleen Australia, National Association of People with HIV Australia (NAPWHA) Incorporated, Musculoskeletal Australia , Safer Care Victoria (SCV)

  1/06/22 → 30/05/26

  Project: Research

• Investigation of the molecular machinery enabling phage to enter bacteria.

  Lithgow, T.

  1/03/22 → 28/02/25

  Project: Research

• CALIPSO: Duration of Cardiac Antimicrobial Prophylaxis Outcomes Study (CALIPSO): multicentre, adaptive, double-blind, three-arm, placebo-controlled, non-inferiority trial examining antimicrobial prophylaxis duration in cardiac surgery

  Peel, T., Myles, P., McGiffin, D., Smith, J., Forbes, A., Marasco, S., Pilcher, D., Stewardson, A., Petrie, D., Peleg, A., Wisniewski, J., Russo, P. & Forster, S.

  Department of Health and Aged Care (Australia)

  1/02/22 → 31/05/27

  Project: Research

• Defining Chemotactic Signalling Networks to Identify New Anti-inflammatory Targets

  Stone, M., Foster, S. R., Kufareva, I., Schittenhelm, R., Handel, T. M., Harper, B., Simpson, K. J. & Payne, R.

  1/01/22 → 31/12/25

  Project: Research

• Mechanisms maintaining mitochondrial copper homeostasis

  Maher, M., Newstead, S. & Ryan, M.

  1/01/22 → 31/12/24

  Project: Research

• Advancing the visualisation and quantification of nephrons with MRI.

  Reutens, D. C., Chandra, S. S., Bertram, J., Kurniawan, N. D. & Healy, H. G.

  Australian Research Council (ARC)

  1/01/22 → 31/12/24

  Project: Research

• Developing novel CAR T cell therapy approaches to treat prostate cancer

  Taylor, R., Porter, L., Trapani, J., Darcy, P., Neeson, P. J., Risbridger, G., Risbridger, G., Solomon, B. J., Azad, A. & Furic, L.

  1/01/22 → 31/12/25

  Project: Research

• Defining the inflammatory T cell landscape in ankylosing spondylitis

  Kenna, T., Nel, H. J., Li, Z., Sternes, P., McGonagle, D., Ciccia, F., Haque, A. & Purcell, A.

  1/01/22 → 31/12/25

  Project: Research

• The KidGen National Kidney Genomics Program – improving genomic outcomes for Australian families with genetic kidney disease

  Mallett, A., Alexander, S., Little, M., Simons, C., Smyth, I., Mallawaarachchi, A., Quinlan, C., Deveson, I., Forbes, T., Jayasinghe, K., MacArthur, D., Stark, Z. L., Patel, C. V., Braithwaite, J., Bennetts, B., McCarthy, H. J., Sundaram, M., Faull, R. J., Jose, M. D. & Chakera, A.

  Department of Health and Aged Care (Australia)

  1/06/21 → 31/05/25

  Project: Research

• ARC Training Centre for Cell and Tissue Engineering Technologies

  Meagher, L., Bray, L., Voelcker, N., Risbridger, G., Hutmacher, D. W., Batra, J., Dargaville, T., Elnathan, R., Saifzadeh, S., Heng, T., Aguilar, M., Lim, R., Klein, T. J., Fisher, A., McGovern, J., Dislakis, V., McLellan, A., Dulleck, U., Steck, R., Scott, W., Corrie, S., Thissen, H., Cameron, N., Haupt, L. M., Werner, C., Levett, P., Whyte, S., Forsythe, J., Smith, N., Frith, J., Hicks, C., Rackham, O. J. L., Sohal, A., Polo, J., May, M., Reimers, N., Toh, Y., McKee, J., Adams, M., Obschonka, M., Subramaniam, N., Yambem, S. D., Russell-Bennett, R., Bertram, J., Schierjott, R., Hollands, J., Currie, P., Ball, G., Trapani, J. A., Cadarso Busto, V., Loessner, D., Ecker, R., Boyd, R. L. & Lim, J.

  Australian Research Council (ARC), PolVax Pty Ltd, Cartherics Pty Ltd, TissueGUARD GmbH, Peter MacCallum Cancer Centre, TissueGnostics GmbH

  13/01/21 → 30/11/27

  Project: Research

• NHOMD: Mitigating the risks of mitochondrial donation

  Carroll, J., Mann, J., Herbert, M. & Zander-Fox, D. L.

  1/01/21 → 31/12/24

  Project: Research

• A bispecific antibody to synergise checkpoint blockers in oncology

  Robert, R., Mackay, C., Caminschi, I. & Cowley, M.

  1/01/21 → 31/12/24

  Project: Research

• Virulence Associated small RNAs in Acinetobacter baumannii

  Peleg, A., Boyce, J., Vogel, J. & Short, F.

  National Health and Medical Research Council (NHMRC) (Australia)

  1/01/21 → 31/12/24

  Project: Research

• Targeting Antimicrobial Resistance and Host Immune Evasion in Staphylococcus aureus

  Peleg, A., Jiang, J. & Shen, H.

  National Health and Medical Research Council (NHMRC) (Australia)

  1/01/21 → 31/12/24

  Project: Research

• ARC Centre of Excellence for Innovations in Peptide and Protein Science

  Craik, D. J., Payne, R., Belov, K., Jolliffe, K. A., New, E., Fairlie, D., King, G. F., Henriques, S. T., Otting, G., Malins, L., Jackson, C., Cryle, M., Challis, G., Colgrave, M., Ploegh, H., Baker, D. A., Suga, H., Davis, B. G., Pentelute, B., van der Donk, W., Tavassoli, A. & Savage, G.

  23/12/20 → 21/01/28

  Project: Research

• Multidisciplinary catalyst to discover and progress novel antimalarial drugs

  Creek, D., Charman, S., de Koning-Ward, T. F., Gilson, P., McGowan, S. & Scammells, P.

  National Health and Medical Research Council (NHMRC) (Australia)

  1/01/20 → 31/12/25

  Project: Research

• Novel therapeutic approaches for SLE

  Mackay, F., Mackay, C. & Hibbs, M.

  Lupus Research Alliance

  1/12/19 → 31/05/25

  Project: Research

• JDRF Strategic Research Agreement - Novel Adjunctive Therapeutic For T1D; a-MSH/MC5R agonist axis

  Cowley, M., Sleeman, M., Thompson, P., Wentworth, J. & Kelly, L.

  1/07/19 → 28/02/25

  Project: Research

• Advancing innovative therapies against pandrug-resistant Gram-negative superbugs

  Li, J., Zhou, Q., Rao, G., Kaye, K. S. & Velkov, T.

  NIH - National Institutes of Health (United States of America)

  1/07/19 → 30/06/25

  Project: Other

• Mechanisms of itch - from endosomal signalling to neural circuits

  Imlach, W. & De Koninck, Y.

  23/06/19 → 1/12/24

  Project: Research

• Not started

  Dynamic assembly of mRNP complexes in response to differentiation and stress

  Anko, M., Preiss, T. & Straesser, K.

  Monash University – Internal University Contribution

  Project: Research

• New Generation Combination Therapies for Advanced Prostate Cancer

  Lawrence, M., Simpson, K. J., Risbridger, G. & Joshua, A.

  Project: Research

• Signalling pathways for sexual differentiation of apicomplexan parasites

  Maier, A. G., Doerig, C. & Tobin, A. B.

  Project: Research

• Finished

  Development of a novel computational pathology platform to identify bowel cancer patients at risk of relapse

  Engel, R., McMurrick, P., Abud, H., Song, J. & Nickless, D.

  1/08/23 → 31/08/24

  Project: Research

• A new therapy to mature preterm lungs without damaging the brain

  Gatford, K., Morrison, J. L., Stark, M. J., Tai, A., Wiese, M., Wallace, M., Cole, T., Clifton, V., Darby, J. R. T. & Meakin, A.

  1/01/23 → 31/12/23

  Project: Research

• FLPF 2023: Future Leaders Postdoctoral Fellowship

  Lister, N.

  1/01/23 → 31/12/23

  Project: Research

• Phase 1b/2a, Randomized, Double-Blind, Placebo-Controlled, Multiple Ascending Dose Escalation Study of the Safety, Tolerability, and Efficacy of Intravenous AP-SA02 as an Adjunct to Best Available Antibiotic Therapy Compared to Best Available Antibiotic Therapy Alone for the Treatment of Adults With Bacteremia Due to Staphylococcus aureus

  Peleg, A. & Roney, J.

  18/10/22 → 1/09/24

  Project: Research

• Empirical assay validation testing - Zymergen

  McGowan, S.

  Zymergen Inc

  15/04/22 → 14/04/23

  Project: Research

• Ovalbumin Specific iTreg for the treatment of Inflammatory Bowel Disease

  Goldberg, R., Ooi, J. & Zaph, C.

  17/03/22 → 15/12/22

  Project: Research

• ERAP inhibitors in cancer immunotherapy

  Purcell, A.

  17/02/22 → 30/04/24

  Project: Research

• ERAP inhibitor in vivo pharmacology study

  Purcell, A.

  10/01/22 → 30/08/22

  Project: Research

• Ferring Innovation Grant for Racial Equality in Reproductive Medicine and Maternal Health: Inflammasomes, novel regulators of placental inflammation and placental ageing in early-onset preeclampsia: potential biomarkers to identify ethnic disparity in preeclampsia

  Murthi, P., Kumar, B., Samuel, C., Chakraborty, A., Brennecke, S. P. & Karanam, V.

  1/12/21 → 1/11/22

  Project: Research

• The Monash Phage Foundry

  Lithgow, T., Li, J., Barr, J., Peleg, A. & Banaszak Holl, M.

  1/10/21 → 31/12/22

  Project: Research

• Identifying therapies that reduce transmission of mitochondrial heteroplasmy from mother to child.

  Robker, R. & Carroll, J.

  1/10/21 → 31/12/21

  Project: Research

• Lead optimisation of novel inhibitors of IRAP for the treatment of fibrosis in diabetes-induced renal and cardiovascular disease

  Gaspari, T., Chai, S., Widdop, R., Thompson, P., Nielsen, K., Perez, S., Dear, A., Yun, B., Pfleger, K. & Barlow, N.

  1/10/21 → 30/11/23

  Project: Research

• AI for estimating global bushfire smoke and its health burden

  Guo, Y., Ge, Z., Li, S. & Song, J.

  1/09/21 → 31/08/22

  Project: Research

• Inhibiting cystogenesis in Polycystic Kidney Disease with AURKA PROTACs

  Zhao, Y., Cottle, D., Smyth, I. & Baell, J.

  30/08/21 → 30/08/22

  Project: Research

• Using functional genomics to diagnose ADPKD

  Smyth, I., Quinlan, C. & Forbes, T.

  1/08/21 → 31/07/22

  Project: Research

• Personalising cancer medicine part II: Expanding the organoid program to include treatment-exposed metastatic colorectal cancer

  Engel, R., Mendis, S., McMurrick, P. & Abud, H.

  1/07/21 → 30/06/22

  Project: Research

• Phage Australia

  Iredell, J. R., Lin, R. C. Y., Khatami, A., Maddocks, S., Lithgow, T., Peleg, A., Paterson, D. L., Warner, M. S., Stick, S., Byrne, J., Williamson, D. A., Tong, S. Y. C., Sintchenko, V., Barr, J., Li, J. & Dunse, K.

  15/06/21 → 14/06/22

  Project: Research

• Defining NF1 clinical variation at the microscale to discover new therapeutic targets

  Ellisdon, A., Halls, M., Schittenhelm, R., Morand, E., Whisstock, J. & Sloan, E.

  1/06/21 → 31/05/24

  Project: Research