Research Output 2017 2019

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2019

Brown adipose tissue thermogenesis in polycystic ovary syndrome

Shorakae, S., Jona, E., de Courten, B., Lambert, G. W., Lambert, E. A., Phillips, S. E., Clarke, I. J., Teede, H. J. & Henry, B. A., 1 Mar 2019, In : Clinical Endocrinology. 90, 3, p. 425-432 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Determining the effects of combined liraglutide and phentermine on metabolic parameters, blood pressure, and heart rate in lean and obese Male mice

Simonds, S. E., Pryor, J. T., Koegler, F. H., Buch-Rasmussen, A. S., Kelly, L. E., Grove, K. L. & Cowley, M. A., 1 Apr 2019, In : Diabetes. 68, 4, p. 683-695 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Food hypersensitivity-induced chronic gastrointestinal inflammation in a non-human primate model of diet-induced obesity

Mustafa, T., Li, Q., Kelly, L. E., Gibbon, A., Ryan, I., Roffey, K., Simonds, S., Cowley, M. A. & Sleeman, M. W., 4 Apr 2019, In : PLoS ONE. 14, 4, 18 p., e0214621.

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Identification of Metabolically Distinct Adipocyte Progenitor Cells in Human Adipose Tissues

Raajendiran, A., Ooi, G., Bayliss, J., O'Brien, P. E., Schittenhelm, R. B., Clark, A. K., Taylor, R. A., Rodeheffer, M. S., Burton, P. R. & Watt, M. J., 30 Apr 2019, In : Cell Reports. 27, 5, p. 1528-1540 13 p.

Research output: Contribution to journalArticleResearchpeer-review

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Leptin Signaling in the Arcuate Nucleus Reduces Insulin's Capacity to Suppress Hepatic Glucose Production in Obese Mice

Balland, E., Chen, W., Dodd, G. T., Conductier, G., Coppari, R., Tiganis, T. & Cowley, M. A., 8 Jan 2019, In : Cell Reports. 26, 2, p. 346-355 10 p.

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Lipopolysaccharide reduces gonadotrophin-releasing hormone (GnRH) gene expression: Role of RFamide-related peptide-3 and kisspeptin

Lee, C. Y., Li, S. Y., Li, X. F., Stalker, D. A. E., Cooke, C., Shao, B., Kelestimur, H., Henry, B. A., Conductier, G., O'Byrne, K. T. & Clarke, I. J., 29 Mar 2019, In : Reproduction, Fertility and Development. 31, 6, p. 1134-1143 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Persistent Leptin Signaling in the Arcuate Nucleus Impairs Hypothalamic Insulin Signaling and Glucose Homeostasis in Obese Mice

Balland, E., Chen, W., Tiganis, T. & Cowley, M. A., 21 Jun 2019, (Accepted/In press) In : Neuroendocrinology. 17 p.

Research output: Contribution to journalArticleResearchpeer-review

Platelet GPIbα is a mediator and potential interventional target for NASH and subsequent liver cancer

Malehmir, M., Pfister, D., Gallage, S., Szydlowska, M., Inverso, D., Kotsiliti, E., Leone, V., Peiseler, M., Surewaard, B. G. J., Rath, D., Ali, A., Wolf, M. J., Drescher, H., Healy, M. E., Dauch, D., Kroy, D., Krenkel, O., Kohlhepp, M., Engleitner, T., Olkus, A. & 46 others, Sijmonsma, T., Volz, J., Deppermann, C., Stegner, D., Helbling, P., Nombela-Arrieta, C., Rafiei, A., Hinterleitner, M., Rall, M., Baku, F., Borst, O., Wilson, C. L., Leslie, J., O’Connor, T., Weston, C. J., Adams, D. H., Sheriff, L., Teijeiro, A., Prinz, M., Bogeska, R., Anstee, N., Bongers, M. N., Notohamiprodjo, M., Geisler, T., Withers, D. J., Ware, J., Mann, D. A., Augustin, H. G., Vegiopoulos, A., Milsom, M. D., Rose, A. J., Lalor, P. F., Llovet, J. M., Pinyol, R., Tacke, F., Rad, R., Matter, M., Djouder, N., Kubes, P., Knolle, P. A., Unger, K., Zender, L., Nieswandt, B., Gawaz, M., Weber, A. & Heikenwalder, M., 1 Apr 2019, In : Nature Medicine. 25, 4, p. 641-655 15 p.

Research output: Contribution to journalArticleResearchpeer-review

Role of peptide hormones in the adaptation to altered dietary protein intake

Rose, A. J., 1 Sep 2019, In : Nutrients. 11, 9, 13 p., 1990.

Research output: Contribution to journalArticleResearchpeer-review

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Suppressing fatty acid uptake has therapeutic effects in preclinical models of prostate cancer

Watt, M. J., Clark, A. K., Selth, L. A., Haynes, V. R., Lister, N., Rebello, R., Porter, L. H., Niranjan, B., Whitby, S. T., Lo, J., Huang, C., Schittenhelm, R. B., Anderson, K. E., Furic, L., Wijayaratne, P. R., Matzaris, M., Montgomery, M. K., Papargiris, M., Norden, S., Febbraio, M. & 4 others, Risbridger, G. P., Frydenberg, M., Nomura, D. K. & Taylor, R. A., 6 Feb 2019, In : Science Translational Medicine. 11, 478, 12 p., eaau5758.

Research output: Contribution to journalArticleResearchpeer-review

The next big LEAP2 understanding ghrelin function

Andrews, Z. B., 3 Sep 2019, In : The Journal of clinical investigation. 129, 9, p. 3542-3544 3 p.

Research output: Contribution to journalArticleOtherpeer-review

2018

Absence of renal hypoxia in the subacute phase of severe renal ischemia-reperfusion injury

Ow, C. P. C., Ngo, J. P., Ullah, M. M., Barsha, G., Meex, R. C., Watt, M. J., Hilliard, L. M., Koeners, M. P. & Evans, R. G., Nov 2018, In : American Journal of Physiology - Renal Physiology. 315, 5, p. F1358-F1369 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Celastrol Promotes Weight Loss in Diet-Induced Obesity by Inhibiting the Protein Tyrosine Phosphatases PTP1B and TCPTP in the Hypothalamus

Kyriakou, E., Schmidt, S., Dodd, G. T., Pfuhlmann, K., Simonds, S. E., Lenhart, D., Geerlof, A., Schriever, S. C., De Angelis, M., Schramm, K. W., Plettenburg, O., Cowley, M. A., Tiganis, T., Tschöp, M. H., Pfluger, P. T., Sattler, M. & Messias, A. C., 7 Dec 2018, In : Journal of Medicinal Chemistry. 61, 24, 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Continuous kisspeptin restores luteinizing hormone pulsatility following cessation by a neurokinin b antagonist in female sheep

Clarke, I. J., Li, Q., Henry, B. A. & Millar, R. P., 1 Feb 2018, In : Endocrinology. 159, 2, p. 639-646 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Dietary protein dilution limits dyslipidemia in obesity through FGF21-driven fatty acid clearance

Maida, A., Zota, A., Vegiopoulos, A., Appak-Baskoy, S., Augustin, H. G., Heikenwalder, M., Herzig, S. & Rose, A. J., 1 Jul 2018, In : Journal of Nutritional Biochemistry. 57, p. 189-196 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Insights into the neurochemical signature of the Innervation of Beige Fat

Stefanidis, A., Wiedmann, N. M., Tyagi, S., Allen, A. M., Watt, M. J. & Oldfield, B. J., 1 May 2018, In : Molecular Metabolism. 11, p. 47-58 12 p.

Research output: Contribution to journalArticleResearchpeer-review

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Insulin regulates POMC neuronal plasticity to control glucose metabolism

Dodd, G. T., Michael, N. J., Lee-Young, R. S., Mangiafico, S. P., Pryor, J. T., Munder, A. C., Simonds, S. E., Brüning, J. C., Zhang, Z-Y., Cowley, M. A., Andrikopoulos, S., Horvath, T. L., Spanswick, D. & Tiganis, T., 19 Sep 2018, In : eLife. 7, 30 p., e38704.

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No evidence of white adipocyte browning after endurance exercise training in obese men

Tsiloulis, T., Carey, AL., Bayliss, J., Canny, B., Meex, RCR. & Watt, MJ., 1 Apr 2018, In : International Journal of Obesity. 42, 4, p. 721-727 7 p.

Research output: Contribution to journalArticleResearchpeer-review

NOX2 oxidase expressed in endosomes promotes cell proliferation and prostate tumour development

Harrison, I. P., Vinh, A., Johnson, I. R. D., Luong, R., Drummond, G. R., Sobey, C. G., Tiganis, T., Williams, E. D., O'Leary, J., Brooks, D. A. & Selemidis, S., 23 Oct 2018, In : Oncotarget. 9, 83, p. 35378-35393 16 p.

Research output: Contribution to journalArticleResearchpeer-review

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Perilipin 5 deletion unmasks an endoplasmic reticulum Stress-Fibroblast growth factor 21 axis in skeletal muscle

Montgomery, M. K., Mokhtar, R., Bayliss, J., Parkington, H. C., Suturin, V. M., Bruce, C. R. & Watt, M. J., 1 Apr 2018, In : Diabetes. 67, 4, p. 594-606 13 p.

Research output: Contribution to journalArticleResearchpeer-review

TCPTP Regulates Insulin Signaling in AgRP Neurons to Coordinate Glucose Metabolism With Feeding

Dodd, G. T., Lee-Young, R. S., Brüning, J. C. & Tiganis, T., 1 Jul 2018, In : Diabetes. 67, 7, p. 1246-1257 12 p.

Research output: Contribution to journalArticleResearchpeer-review

The influence of aerobic exercise on hippocampal integrity and function: Preliminary findings of a multi-modal imaging analysis

Den Ouden, L., Kandola, A., Suo, C., Hendrikse, J., Costa, R., Watt, M. J., Lorenzetti, V., Chye, Y., Parkes, L., Sabaroedin, K. & Yücel, M., 26 Dec 2018, In : Brain Plasticity. 4, 2, p. 211-216 6 p.

Research output: Contribution to journalArticleResearchpeer-review

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Upregulation of tryptophanyl-tRNA synthethase adapts human cancer cells to nutritional stress caused by tryptophan degradation

Adam, I., Dewi, D. L., Mooiweer, J., Sadik, A., Mohapatra, S. R., Berdel, B., Keil, M., Sonner, J. K., Thedieck, K., Rose, A. J., Platten, M., Heiland, I., Trump, S. & Opitz, C. A., 2 Dec 2018, In : OncoImmunology. 7, 12, 14 p., e1486353.

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2017

A Hypothalamic Phosphatase Switch Coordinates Energy Expenditure with Feeding

Dodd, G. T., Andrews, Z. B., Simonds, S. E., Michael, N. J., DeVeer, M., Brüning, J. C., Spanswick, D., Cowley, M. A. & Tiganis, T., 1 Aug 2017, In : Cell Metabolism. 26, 2, p. 375-393 20 p.

Research output: Contribution to journalArticleResearchpeer-review

Altered cross-talk between the hypothalamus and non-homeostatic regions linked to obesity and difficulty to lose weight

Contreras-Rodríguez, O., Vilar-López, R., Andrews, Z. B., Navas, J. F., Soriano-Mas, C. & Verdejo-García, A., 1 Dec 2017, In : Scientific Reports. 7, 1, 9 p., 9951.

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Innate Obesity, Revealed by Selection Markers, Confers Significant Imprint of Hypothalamic Genes Controlling Energy Expenditure

Henry, B. A., 1 Apr 2017, In : Neuroendocrinology. 104, 4, p. 319-329 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Mitochondrial uncoupling in the melanocortin system differentially regulates NPY and POMC neurons to promote weight-loss

Michael, N. J., Simonds, S. E., Van Den Top, M., Cowley, M. A. & Spanswick, D., Oct 2017, In : Molecular Metabolism. 6, 10, p. 1103-1112 10 p.

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Prevention of the adverse effects of olanzapine on lipid metabolism with the antiepileptic zonisamide

Stefanidis, A., Watt, M. J., Cowley, M. A. & Oldfield, B. J., 1 Sep 2017, In : Neuropharmacology. 123, p. 55-66 12 p.

Research output: Contribution to journalArticleResearchpeer-review

The impact of ageing, fasting and high-fat diet on central and peripheral glucose tolerance and glucose-sensing neural networks in the arcuate nucleus

van den Top, M., Zhao, F-Y., Viriyapong, R., Michael, N. J., Munder, A. C., Pryor, J. T., Renaud, L. P. & Spanswick, D., 1 Oct 2017, In : Journal of Neuroendocrinology. 29, 10, 23 p., e12528.

Research output: Contribution to journalArticleResearchpeer-review