Research Output 1977 2019

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Review Article
2019
2 Citations (Scopus)

N-Heterocyclic Carbene Catalyzed (5+1) Annulations Exploiting a Vinyl Dianion Synthon Strategy

Nguyen, X. B., Nakano, Y., Duggan, N. M., Scott, L., Breugst, M. & Lupton, D. W., 1 Jan 2019, In : Angewandte Chemie - International Edition. 58, 33, p. 11483-11490 8 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

4 Citations (Scopus)

Structural Determinants of Isoform Selectivity in PI3K Inhibitors

Miller, M. S., Thompson, P. E. & Gabelli, S. B., 26 Feb 2019, In : Biomolecules. 9, 3, 35 p., 82.

Research output: Contribution to journalReview ArticleResearchpeer-review

Open Access
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4 Citations (Scopus)

The role of dihydrosphingolipids in disease

Magaye, R. R., Savira, F., Hua, Y., Kelly, D. J., Reid, C., Flynn, B., Liew, D. & Wang, B. H., Mar 2019, In : Cellular and Molecular Life Sciences. 76, 6, p. 1107-1134 28 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

2018

Cyclophilin Succumbs to a Macrocyclic Chameleon

Doak, B. C. & Kihlberg, J., 8 Nov 2018, In : Journal of Medicinal Chemistry. 61, 21, p. 9469-9472 4 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

2 Citations (Scopus)

Disordered epitopes as peptide vaccines

MacRaild, C. A., Seow, J., Das, S. C. & Norton, R. S., May 2018, In : Peptide Science. 110, 3, 11 p., e24067.

Research output: Contribution to journalReview ArticleResearchpeer-review

28 Citations (Scopus)

Free Energy Methods in Drug Design: Prospects of "Alchemical Perturbation" in Medicinal Chemistry

Williams-Noonan, B. J., Yuriev, E. & Chalmers, D. K., 8 Feb 2018, In : Journal of Medicinal Chemistry. 61, 3, p. 638-649 12 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

Opening the black box of neural networks: methods for interpreting neural network models in clinical applications

Zhang, Z., Beck, M. W., Winkler, D. A., Huang, B., Sibanda, W., Goyal, H. & AME Big-Data Clinical Trial Collaborative Group, 2018, In : Annals of Translational Medicine. 6, 11, p. 1-11 11 p., 216.

Research output: Contribution to journalReview ArticleResearchpeer-review

Open Access
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10 Citations (Scopus)

Opportunities and guidelines for discovery of orally absorbed drugs in beyond rule of 5 space

Poongavanam, V., Doak, B. C. & Kihlberg, J., 1 Jun 2018, In : Current Opinion in Chemical Biology. 44, p. 23-29 7 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

26 Citations (Scopus)

Photoswitchable Molecules in Long-Wavelength Light-Responsive Drug Delivery: From Molecular Design to Applications

Jia, S., Fong, W. K., Graham, B. & Boyd, B. J., 8 May 2018, In : Chemistry of Materials. 30, 9, p. 2873-2887 15 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

6 Citations (Scopus)

Reviewing Hit Discovery Literature for Difficult Targets: Glutathione Transferase Omega-1 as an Example

Xie, Y., Dahlin, J. L., Oakley, A. J., Casarotto, M. G., Board, P. G. & Baell, J. B., 13 Sep 2018, In : Journal of Medicinal Chemistry. 61, 17, p. 7448-7470 23 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

30 Citations (Scopus)

Sea anemones: Quiet achievers in the field of peptide toxins

Prentis, P. J., Pavasovic, A. & Norton, R. S., 8 Jan 2018, In : Toxins. 10, 1, 15 p., 36.

Research output: Contribution to journalReview ArticleResearchpeer-review

Open Access
File
78 Citations (Scopus)

Seven Year Itch: Pan-Assay Interference Compounds (PAINS) in 2017 - Utility and Limitations

Baell, J. B. & Nissink, J. W. M., 19 Jan 2018, In : ACS Chemical Biology. 13, 1, p. 36-44 9 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

1 Citation (Scopus)

The influence and manipulation of acid/base properties in drug discovery

Manallack, D. T., Yuriev, E. & Chalmers, D. K., 1 Jul 2018, In : Drug Discovery Today: Technologies. 27, p. 41-47 7 p.

Research output: Contribution to journalReview ArticleOtherpeer-review

Open Access
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2017
16 Citations (Scopus)

Antibody recognition of aberrant glycosylation on the surface of cancer cells

Soliman, C., Yuriev, E. & Ramsland, P., 1 Jun 2017, In : Current Opinion in Structural Biology. 44, p. 1-8 8 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

2 Citations (Scopus)

Antimalarial drug discovery targeting apical membrane antigen 1

Devine, S. M., MacRaild, C. A., Norton, R. S. & Scammells, P. J., 2017, In : MedChemComm. 8, 1, p. 13-20 8 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

3 Citations (Scopus)

Biomimetic molecular design tools that learn, evolve, and adapt

Winkler, D., 29 Jun 2017, In : Beilstein Journal of Organic Chemistry. 13, p. 1288-1302 15 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

36 Citations (Scopus)

Computational Modeling and Simulation of CO2 Capture by Aqueous Amines

Yang, X., Rees, R. J., Conway, W., Puxty, G., Yang, Q. & Winkler, D. A., 18 May 2017, In : Chemical Reviews. 117, 14, p. 9524-9593 70 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

2 Citations (Scopus)

Computational modelling of magnetic nanoparticle properties and in vivo responses

Winkler, D. A., 1 Mar 2017, In : Current Medicinal Chemistry. 24, 5, p. 483-496 14 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

17 Citations (Scopus)

Enhancing the therapeutic potential of peptide toxins

Norton, R. S., 3 Jun 2017, In : Expert Opinion on Drug Discovery. 12, 6, p. 611-623 13 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

15 Citations (Scopus)

M1 aminopeptidases as drug targets: Broad applications or therapeutic niche?

Drinkwater, N., Lee, J., Yang, W., Malcolm, T. R. & McGowan, S., May 2017, In : FEBS Journal. 284, 10, p. 1473-1488 16 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

Open Access
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25 Citations (Scopus)

Peptide blockers of Kv1.3 channels in T cells as therapeutics for autoimmune disease

Chandy, G. K. & Norton, R. S., 1 Jun 2017, In : Current Opinion in Chemical Biology. 38, p. 97-107 11 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

10 Citations (Scopus)

Predicting the performance of organic corrosion inhibitors

Winkler, D. A., 1 Dec 2017, In : Metals. 7, 12, 8 p., 533.

Research output: Contribution to journalReview ArticleResearchpeer-review

Open Access
File
14 Citations (Scopus)

Toward a systematic exploration of nano-bio interactions

Bai, X., Liu, F., Liu, Y., Li, C., Wang, S., Zhou, H., Wang, W., Zhu, H., Winkler, D. A. & Yan, B., 15 May 2017, In : Toxicology and Applied Pharmacology. 323, p. 66-73 8 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

2016
28 Citations (Scopus)

Applications of 19F-NMR in fragment-based drug discovery

Norton, R. S., Leung, E. W. W., Chandrashekaran, I. R. & MacRaild, C. A., 1 Jul 2016, In : Molecules. 21, 7, 13 p., 860.

Research output: Contribution to journalReview ArticleResearchpeer-review

Open Access
File
139 Citations (Scopus)

Feeling nature's PAINS: natural products, natural product drugs, and Pan Assay Interference Compounds (PAINS)

Baell, J. B., 25 Mar 2016, In : Journal of Natural Products. 79, 3, p. 616-628 13 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

7 Citations (Scopus)

Guidelines for the Synthesis of Small-Molecule Irreversible Probes Targeting G Protein-Coupled Receptors

Jorg, M. & Scammells, P. J., 19 Jul 2016, In : ChemMedChem. 11, 14, p. 1488-1498 11 p.

Research output: Contribution to journalReview ArticleOtherpeer-review

3 Citations (Scopus)

Multivalent approaches and beyond: novel tools for the investigation of dopamine D2 receptor pharmacology

Kopinathan, A., Scammells, P. J., Lane, J. R. & Capuano, B., 1 Jul 2016, In : Future Medicinal Chemistry. 8, 11, p. 1349-1372 24 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

3 Citations (Scopus)

NMR in structural genomics to increase structural coverage of the protein universe: Delivered by Prof. Kurt Wüthrich on 7 July 2013 at the 38th FEBS Congress in St. Petersburg, Russia

Serrano, P., Dutta, S. K., Proudfoot, A., Mohanty, B., Susac, L., Martin, B., Geralt, M., Jaroszewski, L., Godzik, A., Elsliger, M., Wilson, I. A. & Wüthrich, K., 1 Nov 2016, In : FEBS Journal. 283, 21, p. 3870-3881 12 p.

Research output: Contribution to journalReview ArticleOtherpeer-review

33 Citations (Scopus)

Polymyxins: a new hope in combating Gram-negative superbugs?

Velkov, T., Roberts, K. D., Thompson, P. E. & Li, J., 1 Jun 2016, In : Future Medicinal Chemistry. 8, 10, p. 1017-1025 9 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

16 Citations (Scopus)

Targeting bacterial Dsb proteins for the development of anti-virulence agents

Smith, R. P., Paxman, J. J., Scanlon, M. J. & Heras, B., 1 Jul 2016, In : Molecules. 21, 7, 15 p., 811.

Research output: Contribution to journalReview ArticleResearchpeer-review

Open Access
File
16 Citations (Scopus)

The diverse biological properties of the chemically inert noble gases

Winkler, D. A., Thornton, A., Farjot, G. & Katz, I., 1 Apr 2016, In : Pharmacology and Therapeutics. 160, p. 44-64 21 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

2015
3 Citations (Scopus)

Inhibitors of BCATm: a tough nut to crack

Scanlon, M., 24 Sep 2015, In : Journal of Medicinal Chemistry. 58, 18, p. 7138-7139 2 p.

Research output: Contribution to journalReview ArticleOtherpeer-review

2011
21 Citations (Scopus)

C-FMS inhibitors: A patent review

Burns, C. J. & Wilks, A. F., Feb 2011, In : Expert Opinion on Therapeutic Patents. 21, 2, p. 147-165 19 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

2008
7 Citations (Scopus)

MHC and MHC-like molecules: Structural perspectives on the design of the molecular vaccines

Apostolopoulos, V., Yuriev, E., Lazoura, E., Yu, M. & Ramsland, P. A., 1 Jan 2008, In : Human Vaccines. 4, 6, p. 400-409 10 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

2004
33 Citations (Scopus)

A1 adenosine receptor agonists: Medicinal chemistry and therapeutic potential

Hutchinson, S. A. & Scammells, P. J., 12 Jul 2004, In : Current Pharmaceutical Design. 10, 17, p. 2021-2039 19 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

49 Citations (Scopus)

Bayesian neural nets for modeling in drug discovery

Winkler, D. A. & Burden, F. R., May 2004, In : Drug Discovery Today: BIOSILICO. 2, 3, p. 104-111 8 p.

Research output: Contribution to journalReview ArticleOther

1999
14 Citations (Scopus)

Chemical interactions of α-bromoacrylamide reactive dyes with wool

Church, J. S., Davie, A. S., Scammells, P. J. & Tucker, D. J., 25 Nov 1999, In : Review of Progress in Coloration and Related Topics. 29, p. 85-93 9 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

1986
27 Citations (Scopus)

Antigenic repeat structures in proteins of Plasmodium falciparum

Anders, R. F., Shi, P. T., Scanlon, D. B., Leach, S. J., Coppel, R. L., Brown, G. V., Stahl, H. D. & Kemp, D. J., 1 Jan 1986, In : Ciba Foundation Symposium. 119, p. 164-183 20 p.

Research output: Contribution to journalReview ArticleResearchpeer-review