Research Output 1977 2019

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2014

The synthesis of luminescent lanthanide-based chemosensors for the detection of zinc ions

Aulsebrook, M., Graham, B., Grace, M. R. & Tuck, K. L., 2014, In : Tetrahedron. 70, 29, p. 4367 - 4372 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Toward activated homology models of the human M1 muscarinic acetylcholine receptor

Chin, S. P., Buckle, M. J. C., Chalmers, D. K., Yuriev, E. & Doughty, S. W., 2014, In : Journal of Molecular Graphics and Modelling. 49, p. 91 - 98 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Towards chromate-free corrosion inhibitors: structure-property models for organic alternatives

Winkler, D. A., Breedon, M., Hughes, A. E., Burden, F. R., Barnard, A. S., Harvey, T. G. & Cole, I. S., 2014, In : Green Chemistry. 16, 6, p. 3349-3357 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Two-pronged attack: Dual inhibition of Plasmodium falciparum M1 and M17 metalloaminopeptidases by a novel series of hydroxamic acid-based inhibitors

Mistry, S. N., Drinkwater, N., Ruggeri, C., Kannan Sivaraman, K., Loganathan, S., Fletcher, S., Drag, M., Paiardini, A., Avery, V. M., Scammells, P. J. & McGowan, S., 2014, In : Journal of Medicinal Chemistry. 57, p. 9168 - 9183 16 p.

Research output: Contribution to journalArticleResearchpeer-review

Ultrafast fabrication of covalently cross-linked multifunctional graphene oxide monoliths

Wan, W., Li, L., Zhao, Z., Hu, H., Hao, X., Winkler, D. A., Xi, L., Hughes, T. C. & Qiu, J., 2014, In : Advanced Functional Materials. 24, 31, p. 4915-4921 7 p.

Research output: Contribution to journalArticleResearchpeer-review

File

Zwitterionic-coated "stealth" nanoparticles for biomedical applications: Recent advances in countering biomolecular corona formation and uptake by the mononuclear phagocyte system

Pombo-Garcia, K., Zarschler, K., Barbaro, L., Barreto Solano, J. A., O'Malley, W. I., Spiccia, L., Stephan, H. & Graham, B., 2014, In : Small. 10, 13, p. 2516 - 2529 14 p.

Research output: Contribution to journalArticleResearchpeer-review

2013

(+)-Fluorenylethylchloroformate (FLEC) - improved synthesis for application in chiral analysis and peptidomimetic synthesis

Camerino, M. A., Chalmers, D. K. & Thompson, P., 2013, In : Organic and Biomolecular Chemistry. 11, 16, p. 2571 - 2573 3 p.

Research output: Contribution to journalArticleResearchpeer-review

3-(Oxazolo[4,5-b]pyridin-2-yl)anilides as a novel class of potent inhibitors for the kinetoplastid Trypanosoma brucei, the causative agent for human African trypanosomiasis

Ferrins, L., Rahmani, R. S., Sykes, M. L., Jones, A. J., Avery, V. M., Teston, E., Almohaywi, B., Yin, J., Smith, J., Chris, H., White, K. L., Ryan, E., Campbell, M., Charman, S. A., Kaiser, M. & Baell, J. B., 2013, In : European Journal of Medicinal Chemistry. 66, p. 450 - 465 16 p.

Research output: Contribution to journalArticleResearchpeer-review

A chemogenomic analysis of ionization constants-implications for drug discovery

Manallack, D. T., Prankerd, R. J., Nassta, G., Ursu, O., Oprea, T. I. & Chalmers, D. K., 2013, In : ChemMedChem. 8, 2, p. 242 - 255 14 p.

Research output: Contribution to journalArticleResearchpeer-review

A multi-step continuous flow process for the N-demethylation of alkaloids

Nakano, Y., Savage, G. P., Saubern, S., Scammells, P. J. & Polyzos, A., 2013, In : Australian Journal of Chemistry. 66, 2, p. 178 - 182 5 p.

Research output: Contribution to journalArticleResearchpeer-review

An allosteric modulator of the adenosine A1 receptor improves cardiac function following ischaemia in murine isolated hearts

Butcher, A., Scammells, P. J., White, P. J., Devine, S. & Rose'Meyer, R. B., 2013, In : Pharmaceuticals. 6, 4, p. 546 - 556 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

A novel class of anticancer compounds targets the actin cytoskeleton in tumor cells

Stehn, J., Haass, N. K., Bonello, T., Desouza, M., Kottyan, G., Treutlein, H. R., Zeng, J., Nascimento, P. R. B. B., Sequeira, V. B., Butler, T. L., Allanson, M., Fath, T., Hill, T., McCluskey, A., Schevzov, G., Palmer, S. J., Hardeman, E. C., Winlaw, D. S., Reeve, V. E., Dixon, I. & 3 othersWeninger, W., Cripe, T. P. & Gunning, P. W., 2013, In : Cancer Research. 73, 16, p. 5169 - 5182 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

A novel inhibitor of alpha 9 alpha 10 nicotinic acetylcholine receptors from Conus vexillum delineates a new conotoxin superfamily

Luo, S., Christensen, S., Zhangsun, D., Wu, Y., Hu, Y., Zhu, X., Chhabra, S., Norton, R. S. & McIntosh, J. M., 2013, In : PLoS ONE. 8, 1, 10 p., e54648.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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A potent and selective peptide blocker of the Kv1.3 channel: Prediction from free-energy simulations and experimental confirmation

Rashid, M. H., Heinzelmann, G., Huq, R., Tajhya, R. B., Chang, S. J., Chhabra, S., Pennington, M. W., Beeton, C., Norton, R. S. & Kuyucak, S., 2013, In : PLoS ONE. 8, 11, 10 p., e78712.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Applying quantitative structure-activity relationship approaches to nanotoxicology: current status and future potential

Winkler, D., Mombelli, E., Pietroiusti, A., Tran, L., Worth, A., Fadeel, B. & McCall, M. J., 8 Nov 2013, In : Toxicology. 313, 1, p. 15-23 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Aqueous solubility prediction: do crystal lattice interactions help?

Salahinejad, M., Le, T. C. & Winkler, D. A., 2013, In : Molecular Pharmaceutics. 10, 7, p. 2757-2766 10 p.

Research output: Contribution to journalArticleResearchpeer-review

A structure-activity analysis of biased agonism at the dopamine D2 receptor

Shonberg, J., Klein Herenbrink, C., Lopez, L., Christopoulos, A., Scammells, P. J., Capuano, B. & Lane, J. R. D., 2013, In : Journal of Medicinal Chemistry. 56, 22, p. 9199 - 9221 23 p.

Research output: Contribution to journalArticleResearchpeer-review

Asymmetric synthesis of (+)- and (-)-pauciflorol F: Confirmation of absolute stereochemistry

Kerr, D. J., Miletic, M., Manchala, N., White, J. & Flynn, B. L., 2013, In : Organic Letters. 15, 16, p. 4118 - 4121 4 p.

Research output: Contribution to journalArticleResearchpeer-review

AutoMap: A tool for analyzing protein-ligand recognition using multiple ligand binding modes

Agostino, M. J., Mancera, R., Ramsland, P. A. & Yuriev, E., 2013, In : Journal of Molecular Graphics and Modelling. 40, p. 80 - 90 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Blind man's bluff - Elaboration of fragment hits in the absence of structure for the development of antitrypsin deficiency inhibitors

Headey, S. J., Pearce, M. C., Scanlon, M. & Bottomley, S. P., 2013, In : Australian Journal of Chemistry. 66, 12, p. 1525 - 1529 5 p.

Research output: Contribution to journalArticleResearchpeer-review

Broad coverage of commercially available lead-like screening space with fewer than 350,000 compounds

Baell, J. B., 2013, In : Journal of Chemical Information and Modeling. 53, 1, p. 39 - 55 17 p.

Research output: Contribution to journalArticleResearchpeer-review

Capturing the crystal: prediction of enthalpy of sublimation, crystal lattice energy, and melting points of organic compounds

Salahinejad, M., Le, T. C. & Winkler, D. A., 2013, In : Journal of Chemical Information and Modeling. 53, 1, p. 223-229 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Characterization of rabbit morphine 6-dehydrogenase and two NAD+-dependent 3a(17b)-hydroxysteroid dehydrogenases

Endo, S., Matsunaga, T., Fujimoto, A., Kumada, S., Arai, Y., Miura, Y., Mikamo, H., El-Kabbani, O., Yamano, S., Iinuma, M. & Hara, A., 2013, In : Archives of Biochemistry and Biophysics. 529, 2, p. 131 - 139 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Characterization of the novel broad-spectrum kinase inhibitor CTx-0294885 as an affinity reagent for mass spectrometry-based kinome profiling

Zhang, L., Holmes, I. P., Hochgrafe, F., Walker, S. R., Ali, N. A., Humphrey, E. S., Wu, J., de Silva, M., Kersten, W. J. A., Connor, T., Falk, H., Allan, L., Street, I. P., Bentley, J. D., Pilling, P. A., Monahan, B., Peat, T. & Daly, R. J., 2013, In : Journal of Proteome Research. 12, 7, p. 3104 - 3116 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Comparative sequence, structure and redox analyses of Klebsiella pneumoniae DsbA show that anti-virulence target DsbA enzymes fall into distinct classes

Kurth, F., Rimmer, K., Premkumar, L., Mohanty, B., Duprez, W., Halili, M. A., Shouldice, S. R., Heras, B., Fairlie, D. P., Scanlon, M. & Martin, J. L., 2013, In : PLoS ONE. 8, 11, p. 1 - 15 15 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Computational identification of epitopes in the glycoproteins of novel bunyavirus (SFTS virus) recognized by a human monoclonal antibody (MAb 4-5)

Zhang, W., Zeng, X., Zhang, L., Peng, H., Jiao, Y., Zeng, J. & Treutlein, H. R., 2013, In : Journal of Computer-Aided Molecular Design. 27, 6, p. 539 - 550 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Computational modeling and prediction of the complex time-dependent phase behavior of lyotropic liquid crystals under in meso crystallization conditions

Le, T. C., Conn, C. E., Burden, F. R. & Winkler, D. A., 2013, In : Crystal Growth and Design. 13, 3, p. 1267-1276 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Defining the interaction of perforin with calcium and the phospholipid membrane

Traore, D. A. K., Brennan, A. J., Law, R. H. P., Dogovski, C., Perugini, M. A., Lukoyanova, N., Leung, E. W. W., Norton, R. S., Lopez, J., Browne, K. A., Yagita, H., Lloyd, G., Ciccone, A., Verschoor, S., Trapani, J. A., Whisstock, J. & Voskoboinik, I., 2013, In : Biochemical Journal. 456, 3, p. 323 - 335 13 p.

Research output: Contribution to journalArticleResearchpeer-review

De novo design and synthesis of a mu-conotoxin KIIIA peptidomimetic

Brady, R., Zhang, M., Gable, R. W., Norton, R. S. & Baell, J. B., 2013, In : Bioorganic and Medicinal Chemistry Letters. 23, 17, p. 4892 - 4895 4 p.

Research output: Contribution to journalArticleOtherpeer-review

Design, synthesis, characterisation and in vitro studies of hydrophilic, colloidally stable, 64Cu(II)-labelled, ultra-small iron oxide nanoparticles in a range of human cell lines

Pombo-Garcia, K., Zarschler, K., Barreto Solano, J. A., Hesse, J., Spiccia, L., Graham, B. & Stephan, H., 2013, In : RSC Advances. 3, 44, p. 22443 - 22454 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Design and evaluation of the performance of an NMR screening fragment library

Doak, B. C., Morton, C. J., Simpson, J. S. & Scanlon, M., 2013, In : Australian Journal of Chemistry. 66, 12, p. 1465-1472 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Detection and prevention of aggregation-based false positives in STD-NMR-based fragment screening

Vom, A., Headey, S. J., Wang, G., Capuano, B., Yuriev, E., Scanlon, M. & Simpson, J. S., 2013, In : Australian Journal of Chemistry. 66, 12, p. 1518 - 1524 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Development of inhibitors of Plasmodium falciparum apical membrane antigen 1 based on fragment screening

Lim, S. S., Debono, C., MacRaild, C. A., Chandrashekaran, I. R., Dolezal, O., Anders, R. F., Simpson, J. S., Scanlon, M., Devine, S., Scammells, P. J. & Norton, R. S., 2013, In : Australian Journal of Chemistry. 66, 12, p. 1530 - 1536 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Development of M1 mAChR allosteric and bitopic ligands: Prospective therapeutics for the treatment of cognitive deficits

Davie, B. J., Christopoulos, A. & Scammells, P. J., 2013, In : ACS Chemical Neuroscience. 4, 7, p. 1026 - 1048 23 p.

Research output: Contribution to journalArticleResearchpeer-review

Dicarba alpha-conotoxin Vc1.1 analogues with differential selectivity for nicotinic acetylcholine and GABA(B) receptors

Van Lierop, B. J., Robinson, S., Kompella, S. N., Belgi, A., McArthur, J. R., Hung, A., MacRaild, C. A., Adams, D. J., Norton, R. S. & Robinson, A. J., 2013, In : ACS Chemical Biology. 8, 8, p. 1815 - 1821 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Discovery of potent and selective benzothiazole hydrazone inhibitors of Bcl-XL

Sleebs, B., Kersten, W. J. A., Kulasegaram, S., Nikolakopoulos, G., Hatzis, E., Moss, R. M., Parisot, J. P., Yang, H., Czabotar, P. E., Fairlie, W. D., Lee, E. F., Adams, J. M., Chen, L., van Delft, M. F., Lowes, K. N., Wei, A., Huang, D. CS., Colman, P. M., Street, I. P., Baell, J. B. & 2 othersWatson, K. G. & Lessene, G., 2013, In : Journal of Medicinal Chemistry. 56, 13, p. 5514 - 5540 27 p.

Research output: Contribution to journalArticleResearchpeer-review

Distinct binding properties of TIAR RRMs and linker region

Kim, H., Headey, S. J., Yoga, Y. M. K., Scanlon, M., Gorospe, M., Wilce, M. C. J. & Wilce, J. A., 2013, In : RNA Biology. 10, 4, p. 579 - 589 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Drug discovery and human African trypanosomiasis: A disease less neglected?

Ferrins, L., Rahmani, R. S. & Baell, J. B., 2013, In : Future Medicinal Chemistry. 5, 15, p. 1801 - 1841 41 p.

Research output: Contribution to journalArticleResearchpeer-review

Effect of linker length and composition on heterobivalent ligand-mediated receptor cross-talk between the A1 adenosine and beta2 adrenergic receptors

Barlow, N., Baker, S. P. & Scammells, P. J., 2013, In : ChemMedChem. 8, 12, p. 2036 - 2046 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Electrochemical surface-enhanced Raman spectroscopy (E-SERS) of novel biodegradable ionic liquids

Harroun, S. G., Abraham, T. J., Prudhoe, C., Zhang, Y., Scammells, P. J., Brosseau, C. L., Pye, C. C. & Singer, R. D., 2013, In : Physical Chemistry Chemical Physics. 15, 44, p. 19205 - 19212 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Exploring the chemical space around 8-mercaptoguanine as a route to new inhibitors of the folate biosynthesis enzyme HPPK

Chhabra, S., Barlow, N., Dolezal, O., Hattarki, M., Newman, J., Peat, T., Graham, B. & Swarbrick, J. D., 2013, In : PLoS ONE. 8, 4, 15 p., e59535.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Fragment screening on Staphylococcus aureus HPPK - A folate pathway target

Chhabra, S., Dolezal, O., Hattarki, M., Peat, T., Simpson, J. S. & Swarbrick, J. D., 2013, In : Australian Journal of Chemistry. 66, 12, p. 1537 - 1543 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Gadolinium(III) spin labels for high-sensitivity distance measurements in transmembrane helices

Matalon, E., Huber, T., Hagelueken, G., Graham, B., Frydman, V., Feintuch, A., Otting, G. & Goldfarb, D., 2013, In : Angewandte Chemie - International Edition. 52, 45, p. 11831 - 11834 4 p.

Research output: Contribution to journalArticleResearchpeer-review

Glyceride lipid formulations: Molecular dynamics modeling of phase behavior during dispersion and molecular interactions between drugs and excipients

Warren, D., King, D. T., Benameur, H., Pouton, C. W. & Chalmers, D. K., 2013, In : Pharmaceutical Research. 30, 12, p. 3238 - 3253 16 p.

Research output: Contribution to journalArticleResearchpeer-review

Interrogating fragments using a protein thermal shift assay

McMahon, R. M., Scanlon, M. & Martin, J. L., 2013, In : Australian Journal of Chemistry. 66, 12, p. 1502 - 1506 5 p.

Research output: Contribution to journalArticleResearchpeer-review

Intracellular trafficking of the KV1.3 potassium channel is regulated by the prodomain of a matrix metalloprotease

Nguyen, H. M., Galea, C., Schmunk, G., Smith, B. J., Edwards, R. A., Norton, R. S. & Chandy, K. G., 2013, In : Journal of Biological Chemistry. 288, 9, p. 6451 - 6464 14 p.

Research output: Contribution to journalArticleResearchpeer-review

L-aminoacyl-triazine derivatives are isoform-selective PI3KB inhibitors that target nonconserved Asp862 of PI3KB

Pinson, J-A., Zheng, Z., Miller, M. S., Chalmers, D. K., Jennings, I. & Thompson, P., 2013, In : A C S Medicinal Chemistry Letters. 4, 2, p. 206 - 210 5 p.

Research output: Contribution to journalArticleResearchpeer-review

Lanthanide tags for site-specific ligation to an unnatural amino acid and generation of pseudocontact shifts in proteins

Loh, C. T., Ozawa, K., Tuck, K. L., Barlow, N., Huber, T., Otting, G. & Graham, B., 2013, In : Bioconjugate Chemistry. 24, 2, p. 260 - 268 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Latest developments in molecular docking: 2010-2011 in review

Yuriev, E. & Ramsland, P. A., 2013, In : Journal of Molecular Recognition. 26, 5, p. 215 - 239 25 p.

Research output: Contribution to journalArticleResearchpeer-review

Mammalian neuronal sodium channel blocker u-conotoxin BuIIIB has a structured N-terminus that influences potency

Kuang, Z., Zhang, M-M., Gupta, K., Gajewiak, J., Gulyas, J., Balaram, P., Rivier, J. E., Olivera, B. M., Yoshikami, D., Bulaj, G. & Norton, R. S., 2013, In : ACS Chemical Biology. 8, 6, p. 1344 - 1351 8 p.

Research output: Contribution to journalArticleResearchpeer-review