Research Output 1977 2019

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2014
10 Citations (Scopus)

Molecular insights into the interaction between Plasmodium falciparum apical membrane antigen 1 and an invasion-inhibitory peptide

Wang, G., MacRaild, C. A., Mohanty, B., Mobli, M., Cowieson, N. P., Anders, R. F., Simpson, J. S., McGowan, S., Norton, R. S. & Scanlon, M., 2014, In : PLoS ONE. 9, 10, p. 1-12 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
31 Citations (Scopus)

Molecular mechanisms of bitopic ligand engagement with the M1 muscarinic acetylcholine receptor

Keov, P., Lopez, L., Devine, S., Valant, C., Lane, J. R. D., Scammells, P. J., Sexton, P. & Christopoulos, A., 2014, In : Journal of Biological Chemistry. 289, 34, p. 23817 - 23837 21 p.

Research output: Contribution to journalArticleResearchpeer-review

24 Citations (Scopus)

Nitric oxide confers cisplatin resistance in human lung cancer cells through upregulation of aldo-keto reductase 1B10 and proteasome

Matsunaga, T., Yamaji, Y., Tomokuni, T., Morita, H., Morikawa, Y., Suzuki, A., Yonezawa, A., Endo, S., Ikari, A., Iguchi, K., El-Kabbani, O., Tajima, K. & Hara, A., 2014, In : Free Radical Research. 48, 11, p. 1371 - 1385 15 p.

Research output: Contribution to journalArticleResearchpeer-review

2 Citations (Scopus)

NMR case study of ropinirole: Concentration-dependent effects of nonexchangeable proton resonances

Jorg, M. T., Headey, S. J., Scammells, P. J. & Capuano, B., 2014, In : Magnetic Resonance in Chemistry. 52, 11, p. 715-718 4 p.

Research output: Contribution to journalArticleResearchpeer-review

9 Citations (Scopus)

Pharmacological characterization and chemical fractionation of a liposterolic extract of saw palmetto (Serenoa repens): Effects on rat prostate contractility

Chua, T., Eise, N., Simpson, J. S. & Ventura, S., 2014, In : Journal of Ethnopharmacology. 152, 2, p. 283 - 291 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Probing AKR1C30 and AKR1C31 with site-directed mutagenesis: Identifying the roles of residues 54 and 56 in the binding of substrates and inhibitors

Endo, S., Arai, Y., Matsunaga, T., Ikari, A., El-Kabbani, O., Hara, A. & Kitade, Y., 2014, In : Biological & Pharmaceutical Bulletin. 37, 11, p. 1848 - 1852 5 p.

Research output: Contribution to journalArticleResearchpeer-review

49 Citations (Scopus)

Probing the penetration of antimicrobial polymyxin lipopeptides into gram-negative bacteria

Deris, Z. Z., Swarbrick, J. D., Roberts, K. D., Azad, M. A. K., Akter, J., Horne, A. S., Nation, R. L., Rogers, K. L., Thompson, P., Velkov, T. & Li, J., 2014, In : Bioconjugate Chemistry. 25, 4, p. 750 - 760 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
37 Citations (Scopus)

Pyridyl benzamides as a novel class of potent inhibitors for the kinetoplastid Trypanosoma brucei

Ferrins, L., Gazdik, M., Rahmani, R. S., Varghese, S., Sykes, M. L., Jones, A. J., Avery, V. M., White, K. L., Ryan, E., Charman, S. A., Kaiser, M., Bergstrom, C. A. S. & Baell, J. B., 2014, In : Journal of Medicinal Chemistry. 57, 15, p. 6393 - 6402 10 p.

Research output: Contribution to journalArticleResearchpeer-review

12 Citations (Scopus)

RASP: Rapid and robust backbone chemical shift assignments from protein structure

MacRaild, C. A. & Norton, R. S., 2014, In : Journal of Biomolecular NMR. 58, 3, p. 155 - 163 9 p.

Research output: Contribution to journalArticleResearchpeer-review

57 Citations (Scopus)
Open Access
22 Citations (Scopus)

Structural basis of nSH2 regulation and lipid binding in PI3Ka

Miller, M. S., Schmidt-Kittler, O., Bolduc, D. M., Brower, E. T., Chaves-Moreira, D., Allaire, M., Kinzler, K. W., Jennings, I., Thompson, P., Cole, P. A., Amzel, L. M., Vogelstein, B. & Gabelli, S. B., 2014, In : Oncotarget. 5, 14, p. 5198 - 5208 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
45 Citations (Scopus)

Structure-activity relationships of privileged structures lead to the discovery of novel biased ligands at the dopamine D2 receptor

Szabo, M., Klein Herenbrink, C., Christopoulos, A., Lane, J. R. D. & Capuano, B., 2014, In : Journal of Medicinal Chemistry. 57, 11, p. 4924 - 4939 16 p.

Research output: Contribution to journalArticleResearchpeer-review

14 Citations (Scopus)

Structure and dynamics of apical membrane antigen 1 from Plasmodium falciparum FVO

Lim, S. S., Yang, W. W., Krishnarjuna, B., Kannan Sivaraman, K., Chandrashekaran, I. R., Kass, I., MacRaild, C. A., Devine, S., Debono, C., Anders, R. F., Scanlon, M., Scammells, P. J., Norton, R. S. & McGowan, S., 2014, In : Biochemistry. 53, 46, p. 7310 - 7320 11 p.

Research output: Contribution to journalArticleResearchpeer-review

20 Citations (Scopus)

Structure and function of mu-conotoxins, peptide-based sodium channel blockers with analgesic activity

Green, B. R., Bulaj, G. & Norton, R. S., 2014, In : Future Medicinal Chemistry. 6, 15, p. 1677 - 1698 22 p.

Research output: Contribution to journalArticleResearchpeer-review

6 Citations (Scopus)

Structure-based design and development of functionalized mercaptoguanine derivatives as inhibitors of the folate biosynthesis pathway enzyme 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase from Staphylococcus aureus

Dennis, M., Chhabra, S., Wang, Z-C., Debono, A. J., Dolezal, O., Newman, J., Pitcher, N. P., Rahmani, R. S., Cleary, B., Barlow, N., Hattarki, M., Graham, B., Peat, T. S., Baell, J. B. & Swarbrick, J. D., 2014, In : Journal of Medicinal Chemistry. 57, 22, p. 9612 - 9626 15 p.

Research output: Contribution to journalArticleResearchpeer-review

7 Citations (Scopus)

Structure of the chicken CD3epsilon/delta/gamma heterodimer and its assembly with the alphabetaT cell receptor

Berry, R., Headey, S. J., Call, M. J., McCluskey, J., Tregaskes, C. A., Kaufman, J., Koh, R., Scanlon, M., Call, M. E. & Rossjohn, J., 2014, In : Journal of Biological Chemistry. 289, 12, p. 8240 - 8251 12 p.

Research output: Contribution to journalArticleResearchpeer-review

32 Citations (Scopus)

Synthesis, structure-activity relationships and brain uptake of a novel series of benzopyran inhibitors of insulin-regulated aminopeptidase

Mountford, S. J., Albiston, A. L., Charman, W. N., Ng, L., Holien, J. K., Parker, M. W., Nicolazzo, J., Thompson, P. & Chai, S. Y., 2014, In : Journal of Medicinal Chemistry. 57, 4, p. 1368 - 1377 10 p.

Research output: Contribution to journalArticleResearchpeer-review

21 Citations (Scopus)

Synthesis of thieno-fused heterocycles through reiterative iodocyclization

Aurelio, L., Volpe, R., Halim, R., Scammells, P. J. & Flynn, B. L., 2014, In : Advanced Synthesis and Catalysis. 356, 9, p. 1974 - 1978 5 p.

Research output: Contribution to journalArticleResearchpeer-review

4 Citations (Scopus)

Synthetic routes to the Neuropeptide Y Y1 receptor antagonist 1229U91 and related analogues for SAR studies and cell-based imaging

Mountford, S. J., Liu, M., Zhang, L., Groenen, M., Herzog, H., Holliday, N. D. & Thompson, P., 2014, In : Organic and Biomolecular Chemistry. 12, 20, p. 3271 - 3281 11 p.

Research output: Contribution to journalArticleResearchpeer-review

37 Citations (Scopus)

Targeted delivery of a model immunomodulator to the lymphatic system: Comparison of alkyl ester versus triglyceride mimetic lipid prodrug strategies

Han, S., Quach, T., Hu, L., Wahab, A., Charman, W. N., Stella, V. J., Trevaskis, N., Simpson, J. S. & Porter, C. J., 2014, In : Journal of Controlled Release. 177, 1, p. 1 - 10 10 p.

Research output: Contribution to journalArticleResearchpeer-review

61 Citations (Scopus)

Teaching 'old' polymyxins new tricks: New-generation lipopeptides targeting gram-negative 'superbugs'

Velkov, T., Roberts, K. D., Nation, R. L., Wang, J., Thompson, P. & Li, J., 2014, In : ACS Chemical Biology. 9, 5, p. 1172 - 1177 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
31 Citations (Scopus)

The dengue virus NS2B-NS3 protease retains the closed conformation in the complex with BPTI

Chen, W-N., Loscha, K. V., Nitsche, C., Graham, B. & Otting, G., 2014, In : FEBS Letters. 588, 14, p. 2206 - 2211 6 p.

Research output: Contribution to journalArticleResearchpeer-review

30 Citations (Scopus)

The dopamine D2 and adenosine A2A receptors: Past, present and future trends for the treatment of parkinson's disease

Jorg, M. T., Scammells, P. J. & Capuano, B., 2014, In : Current Medicinal Chemistry. 21, 27, p. 3188 - 3210 23 p.

Research output: Contribution to journalArticleResearchpeer-review

18 Citations (Scopus)

The drug vehicle and solvent N-Methylpyrrolidone is an immunomodulator and antimyeloma compound

Shortt, J., Hsu, A. K., Martin, B. P., Doggett, K., Matthews, G. M., Doyle, M. A., Ellul, J., Jockel, T. E., Andrews, D. M. K., Hogg, S. J., Reitsma, A. J., Faulkner, D., Bergsagel, P. L., Chesi, M., Heath, J. K., Denny, W. A., Thompson, P., Neeson, P., Ritchie, D., McArthur, G. A. & 1 others, Johnstone, R. W., 2014, In : Cell Reports. 7, 4, p. 1009 - 1019 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
80 Citations (Scopus)

The NBOMe hallucinogenic drug series: Patterns of use, characteristics of users and self-reported effects in a large international sample

Lawn, W., Barratt, M. J., Williams, M., Horne, A. & Winstock, A. R., 2014, In : Journal of Psychopharmacology. 28, 8, p. 780 - 788 9 p.

Research output: Contribution to journalArticleResearchpeer-review

12 Citations (Scopus)

The role of oxidoreductases in determining the function of the neisserial lipid A phosphoethanolamine transferase required for resistance to polymyxin

Piek, S., Wang, Z., Ganguly, J., Lakey, A. M., Bartley, S. N., Mowlaboccus, S., Anandan, A., Stubbs, K., Scanlon, M., Vrielink, A., Azadi, P., Carlson, R. W. & Kahler, C. M., 2014, In : PLoS ONE. 9, 9, 12 p., e106513.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
19 Citations (Scopus)

The synthesis and biological evaluation of multifunctionalised derivatives of noscapine as cytotoxic agents

Debono, A. J., Mistry, S. J., Xie, A., Muthiah, D., Phillips, J. R., Ventura, S., Callaghan, R., Pouton, C. W., Capuano, B. & Scammells, P. J., 2014, In : ChemMedChem. 9, 2, p. 399 - 410 12 p.

Research output: Contribution to journalArticleResearchpeer-review

14 Citations (Scopus)

The synthesis of luminescent lanthanide-based chemosensors for the detection of zinc ions

Aulsebrook, M., Graham, B., Grace, M. R. & Tuck, K. L., 2014, In : Tetrahedron. 70, 29, p. 4367 - 4372 6 p.

Research output: Contribution to journalArticleResearchpeer-review

10 Citations (Scopus)

Toward activated homology models of the human M1 muscarinic acetylcholine receptor

Chin, S. P., Buckle, M. J. C., Chalmers, D. K., Yuriev, E. & Doughty, S. W., 2014, In : Journal of Molecular Graphics and Modelling. 49, p. 91 - 98 8 p.

Research output: Contribution to journalArticleResearchpeer-review

55 Citations (Scopus)

Towards chromate-free corrosion inhibitors: structure-property models for organic alternatives

Winkler, D. A., Breedon, M., Hughes, A. E., Burden, F. R., Barnard, A. S., Harvey, T. G. & Cole, I. S., 2014, In : Green Chemistry. 16, 6, p. 3349-3357 9 p.

Research output: Contribution to journalArticleResearchpeer-review

26 Citations (Scopus)

Two-pronged attack: Dual inhibition of Plasmodium falciparum M1 and M17 metalloaminopeptidases by a novel series of hydroxamic acid-based inhibitors

Mistry, S. N., Drinkwater, N., Ruggeri, C., Kannan Sivaraman, K., Loganathan, S., Fletcher, S., Drag, M., Paiardini, A., Avery, V. M., Scammells, P. J. & McGowan, S., 2014, In : Journal of Medicinal Chemistry. 57, p. 9168 - 9183 16 p.

Research output: Contribution to journalArticleResearchpeer-review

65 Citations (Scopus)

Ultrafast fabrication of covalently cross-linked multifunctional graphene oxide monoliths

Wan, W., Li, L., Zhao, Z., Hu, H., Hao, X., Winkler, D. A., Xi, L., Hughes, T. C. & Qiu, J., 2014, In : Advanced Functional Materials. 24, 31, p. 4915-4921 7 p.

Research output: Contribution to journalArticleResearchpeer-review

File
215 Citations (Scopus)

Zwitterionic-coated "stealth" nanoparticles for biomedical applications: Recent advances in countering biomolecular corona formation and uptake by the mononuclear phagocyte system

Pombo-Garcia, K., Zarschler, K., Barbaro, L., Barreto Solano, J. A., O'Malley, W. I., Spiccia, L., Stephan, H. & Graham, B., 2014, In : Small. 10, 13, p. 2516 - 2529 14 p.

Research output: Contribution to journalArticleResearchpeer-review

2013
5 Citations (Scopus)

(+)-Fluorenylethylchloroformate (FLEC) - improved synthesis for application in chiral analysis and peptidomimetic synthesis

Camerino, M. A., Chalmers, D. K. & Thompson, P., 2013, In : Organic and Biomolecular Chemistry. 11, 16, p. 2571 - 2573 3 p.

Research output: Contribution to journalArticleResearchpeer-review

20 Citations (Scopus)

3-(Oxazolo[4,5-b]pyridin-2-yl)anilides as a novel class of potent inhibitors for the kinetoplastid Trypanosoma brucei, the causative agent for human African trypanosomiasis

Ferrins, L., Rahmani, R. S., Sykes, M. L., Jones, A. J., Avery, V. M., Teston, E., Almohaywi, B., Yin, J., Smith, J., Chris, H., White, K. L., Ryan, E., Campbell, M., Charman, S. A., Kaiser, M. & Baell, J. B., 2013, In : European Journal of Medicinal Chemistry. 66, p. 450 - 465 16 p.

Research output: Contribution to journalArticleResearchpeer-review

25 Citations (Scopus)

A chemogenomic analysis of ionization constants-implications for drug discovery

Manallack, D. T., Prankerd, R. J., Nassta, G., Ursu, O., Oprea, T. I. & Chalmers, D. K., 2013, In : ChemMedChem. 8, 2, p. 242 - 255 14 p.

Research output: Contribution to journalArticleResearchpeer-review

11 Citations (Scopus)

A multi-step continuous flow process for the N-demethylation of alkaloids

Nakano, Y., Savage, G. P., Saubern, S., Scammells, P. J. & Polyzos, A., 2013, In : Australian Journal of Chemistry. 66, 2, p. 178 - 182 5 p.

Research output: Contribution to journalArticleResearchpeer-review

6 Citations (Scopus)

An allosteric modulator of the adenosine A1 receptor improves cardiac function following ischaemia in murine isolated hearts

Butcher, A., Scammells, P. J., White, P. J., Devine, S. & Rose'Meyer, R. B., 2013, In : Pharmaceuticals. 6, 4, p. 546 - 556 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
70 Citations (Scopus)

A novel class of anticancer compounds targets the actin cytoskeleton in tumor cells

Stehn, J., Haass, N. K., Bonello, T., Desouza, M., Kottyan, G., Treutlein, H. R., Zeng, J., Nascimento, P. R. B. B., Sequeira, V. B., Butler, T. L., Allanson, M., Fath, T., Hill, T., McCluskey, A., Schevzov, G., Palmer, S. J., Hardeman, E. C., Winlaw, D. S., Reeve, V. E., Dixon, I. & 3 others, Weninger, W., Cripe, T. P. & Gunning, P. W., 2013, In : Cancer Research. 73, 16, p. 5169 - 5182 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
29 Citations (Scopus)

A novel inhibitor of alpha 9 alpha 10 nicotinic acetylcholine receptors from Conus vexillum delineates a new conotoxin superfamily

Luo, S., Christensen, S., Zhangsun, D., Wu, Y., Hu, Y., Zhu, X., Chhabra, S., Norton, R. S. & McIntosh, J. M., 2013, In : PLoS ONE. 8, 1, 10 p., e54648.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
37 Citations (Scopus)

A potent and selective peptide blocker of the Kv1.3 channel: Prediction from free-energy simulations and experimental confirmation

Rashid, M. H., Heinzelmann, G., Huq, R., Tajhya, R. B., Chang, S. J., Chhabra, S., Pennington, M. W., Beeton, C., Norton, R. S. & Kuyucak, S., 2013, In : PLoS ONE. 8, 11, 10 p., e78712.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
108 Citations (Scopus)

Applying quantitative structure-activity relationship approaches to nanotoxicology: current status and future potential

Winkler, D., Mombelli, E., Pietroiusti, A., Tran, L., Worth, A., Fadeel, B. & McCall, M. J., 8 Nov 2013, In : Toxicology. 313, 1, p. 15-23 9 p.

Research output: Contribution to journalArticleResearchpeer-review

33 Citations (Scopus)

Aqueous solubility prediction: do crystal lattice interactions help?

Salahinejad, M., Le, T. C. & Winkler, D. A., 2013, In : Molecular Pharmaceutics. 10, 7, p. 2757-2766 10 p.

Research output: Contribution to journalArticleResearchpeer-review

61 Citations (Scopus)

A structure-activity analysis of biased agonism at the dopamine D2 receptor

Shonberg, J., Klein Herenbrink, C., Lopez, L., Christopoulos, A., Scammells, P. J., Capuano, B. & Lane, J. R. D., 2013, In : Journal of Medicinal Chemistry. 56, 22, p. 9199 - 9221 23 p.

Research output: Contribution to journalArticleResearchpeer-review

31 Citations (Scopus)

Asymmetric synthesis of (+)- and (-)-pauciflorol F: Confirmation of absolute stereochemistry

Kerr, D. J., Miletic, M., Manchala, N., White, J. & Flynn, B. L., 2013, In : Organic Letters. 15, 16, p. 4118 - 4121 4 p.

Research output: Contribution to journalArticleResearchpeer-review

10 Citations (Scopus)

AutoMap: A tool for analyzing protein-ligand recognition using multiple ligand binding modes

Agostino, M. J., Mancera, R., Ramsland, P. A. & Yuriev, E., 2013, In : Journal of Molecular Graphics and Modelling. 40, p. 80 - 90 11 p.

Research output: Contribution to journalArticleResearchpeer-review

3 Citations (Scopus)

Blind man's bluff - Elaboration of fragment hits in the absence of structure for the development of antitrypsin deficiency inhibitors

Headey, S. J., Pearce, M. C., Scanlon, M. & Bottomley, S. P., 2013, In : Australian Journal of Chemistry. 66, 12, p. 1525 - 1529 5 p.

Research output: Contribution to journalArticleResearchpeer-review

40 Citations (Scopus)

Broad coverage of commercially available lead-like screening space with fewer than 350,000 compounds

Baell, J. B., 2013, In : Journal of Chemical Information and Modeling. 53, 1, p. 39 - 55 17 p.

Research output: Contribution to journalArticleResearchpeer-review

29 Citations (Scopus)

Capturing the crystal: prediction of enthalpy of sublimation, crystal lattice energy, and melting points of organic compounds

Salahinejad, M., Le, T. C. & Winkler, D. A., 2013, In : Journal of Chemical Information and Modeling. 53, 1, p. 223-229 7 p.

Research output: Contribution to journalArticleResearchpeer-review