Research Output 1977 2019

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25 Citations (Scopus)

Endo selective Diels-Alder reactions of furan in ionic liquids

Hemeon, I., De Amicis, C., Jenkins, H., Scammells, P. & Singer, R. D., 2002, In : Synlett. 11, November, p. 1815 - 1818 4 p.

Research output: Contribution to journalArticleResearchpeer-review

20 Citations (Scopus)

Endosomal NOX2 oxidase exacerbates virus pathogenicity and is a target for antiviral therapy

To, E. E., Vlahos, R., Luong, R., Halls, M. L., Reading, P. C., King, P. T., Chan, C., Drummond, G. R., Sobey, C. G., Broughton, B. R. S., Starkey, M. R., van der Sluis, R., Lewin, S. R., Bozinovski, S., O'Neill, L. A. J., Quach, T., Porter, C. J. H., Brooks, D. A., O'Leary, J. & Selemidis, S., 1 Dec 2017, In : Nature Communications. 8, 1, 17 p., 69.

Research output: Contribution to journalArticleResearchpeer-review

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38 Citations (Scopus)

Endosomal signaling of the receptor for calcitonin gene-related peptide mediates pain transmission

Yarwood, R. E., Imlach, W. L., Lieu, T., Veldhuis, N. A., Jensen, D. D., Herenbrink, C. K., Aurelio, L., Cai, Z., Christie, M. J., Poole, D. P., Porter, C. J. H., McLean, P., Hicks, G. A., Geppetti, P., Halls, M. L., Canals, M. & Bunnett, N. W., 14 Nov 2017, In : Proceedings of the National Academy of Sciences of the United States of America. 114, 46, p. 12309-12314 6 p.

Research output: Contribution to journalArticleResearchpeer-review

37 Citations (Scopus)

Engineering of a bis-chelator motif into a protein alpha-helix for rigid lanthanide binding and paramagnetic NMR spectroscopy

Swarbrick, J., Ung, P., Su, X-C., Maleckis, A., Chhabra, S., Huber, T., Otting, G. & Graham, B., 2011, In : Chemical Communications. 47, p. 7368 - 7370 3 p.

Research output: Contribution to journalArticleResearchpeer-review

39 Citations (Scopus)

Enhanced cytotoxicity through conjugation of a "clickable" luminescent Re(I) complex to a cell-penetrating lipopeptide

Leonidova, A., Pierroz, V., Adams, L. A., Barlow, N., Ferrari, S., Graham, B. & Gasser, G. A., 2014, In : ACS Medicinal Chemistry Letters. 5, 7, p. 809 - 814 6 p.

Research output: Contribution to journalArticleResearchpeer-review

29 Citations (Scopus)

Enhanced extravasation, stability and in vivo cardiac gene silencing via in situ siRNA-albumin conjugation

Lau, S., Graham, B., Cao, N., Boyd, B. J., Pouton, C. W. & White, P. J., 2012, In : Molecular Pharmaceutics. 9, 1, p. 71 - 80 10 p.

Research output: Contribution to journalArticleResearchpeer-review

43 Citations (Scopus)

Enhancing the buccal mucosal delivery of peptide and protein therapeutics

Caon, T., Jin, L., Simoes, M. O. C., Norton, R. S. & Nicolazzo, J., 2015, In : Pharmaceutical Research. 32, 1, p. 1 - 21 21 p.

Research output: Contribution to journalArticleResearchpeer-review

36 Citations (Scopus)

Enhancing the immunogenicity and modulating the fine epitope recognition of antisera to a helical group A streptococcal peptide vaccine candidate from the M protein using lipid-core peptide technology

Hayman, W. A., Toth, I., Flinn, N., Scanlon, M. & Good, M. F., 2002, In : Immunology and Cell Biology. 80, 2, p. 178 - 187 10 p.

Research output: Contribution to journalArticleResearchpeer-review

5 Citations (Scopus)

Enhancing the Oral Absorption of Kinase Inhibitors Using Lipophilic Salts and Lipid-Based Formulations

Williams, H. D., Ford, L., Han, S., Tangso, K. J., Lim, S., Shackleford, D. M., Vodak, D. T., Benameur, H., Pouton, C. W., Scammells, P. J. & Porter, C. J. H., 1 Jan 2018, In : Molecular Pharmaceutics. 15, 12, p. 5678−5696 19 p.

Research output: Contribution to journalArticleResearchpeer-review

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16 Citations (Scopus)

Enzymatic characteristics of an aldo-keto reductase family protein (AKR1C15) and its localization in rat tissues

Endo, S., Matsunaga, T., Horie, K., Tajima, K., Bunai, Y., Carbone, V., El-Kabbani, O. & Hara, A., 2007, In : Archives of Biochemistry and Biophysics. 465, 1, p. 136 - 147 12 p.

Research output: Contribution to journalArticleResearchpeer-review

13 Citations (Scopus)

Enzymatic properties of a member (AKR1C20) of the aldo-keto reductase family

Matsumoto, K., Endo, S., Ishikura, S., Matsunaga, T., Tajima, K., El-Kabbani, O. & Hara, A., 2006, In : Biological & Pharmaceutical Bulletin. 29, 3, p. 539 - 542 4 p.

Research output: Contribution to journalArticleResearchpeer-review

101 Citations (Scopus)

Estimation of pKa using semiempirical molecular orbital methods. Part 1: application to phenols and carboxylic acids

Tehan, B. G., Lloyd, E. J., Wong, M. G., Pitt, W. R., Montana, J. G., Manallack, D. T. & Gancia, E., 2002, In : Quantitative Structure-Activity Relationships. 21, 5, p. 457 - 472 16 p.

Research output: Contribution to journalArticleResearchpeer-review

61 Citations (Scopus)

Estimation of pKa using semiempirical molecular orbital methods. Part 2: application to amines, anilines and various nitrogen containing heterocyclic compounds

Tehan, B. G., Lloyd, E. J., Wong, M. G., Pitt, W. R., Gancia, E. & Manallack, D. T., 2002, In : Quantitative Structure-Activity Relationships. 21, 5, p. 473 - 485 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Estrogen Receptor α (ERα)-targeting Compounds and Derivatives: Recent Advances in Structural Modification and Bioactivity

Guo, W. Y., Zeng, S. M. Z., Deora, G. S., Li, Q. S. & Ruan, B. F., 1 Jan 2019, In : Current Topics in Medicinal Chemistry. 19, 15, p. 1318-1337 20 p.

Research output: Contribution to journalArticleResearchpeer-review

4 Citations (Scopus)

Ethanol extracts of saw palmetto contain the indirectly acting sympathomimetic: tyramine

Chua, T., Simpson, J. & Ventura, S., 2011, In : Prostate. 71, 1, p. 71 - 80 10 p.

Research output: Contribution to journalArticleResearchpeer-review

26 Citations (Scopus)

Evidence for structurally conserved recognition of the major carbohydrate xenoantigen by natural antibodies

Ramsland, P. A., Farrugia, W., Yuriev, E., Edmundson, A. B. & Sandrin, M. S., 2003, In : Cellular and Molecular Biology. 49, 2, p. 307 - 317 11 p.

Research output: Contribution to journalArticleResearchpeer-review

2 Citations (Scopus)

Evidence for the in vitro bioactivation of aminopyrazole derivatives: trapping reactive aminopyrazole intermediates using glutathione ethyl ester in human liver microsomes

Ryan, E., Morrow, B. J., Hemley, C. F., Pinson, J-A., Charman, S. A., Chiu, F. C. K. & Foitzik, R. C., 2015, In : Chemical Research in Toxicology. 28, 9, p. 1747-1752 6 p.

Research output: Contribution to journalArticleResearchpeer-review

3 Citations (Scopus)

Evolution of cnidarian trans-defensins: Sequence, structure and exploration of chemical space

Mitchell, M. L., Shafee, T., Papenfuss, A. T. & Norton, R. S., 1 Jul 2019, In : Proteins: Structure, Function and Bioinformatics. 87, 7, p. 551-560 10 p.

Research output: Contribution to journalArticleResearchpeer-review

29 Citations (Scopus)

Examination of the role of intestinal fatty acid-binding protein in drug absorption using a parallel artificial membrane permeability assay

Velkov, T., Horne, H. J., Laguerre, A. K., Jones, E. D., Scanlon, M. & Porter, C. J., 2007, In : Chemistry and Biology. 14, 4, p. 453 - 465 13 p.

Research output: Contribution to journalArticleResearchpeer-review

4 Citations (Scopus)

Examining the gastrointestinal transit of lipid-based liquid crystalline systems using whole-animal imaging

Pham, A. C., Nguyen, T-H., Nowell, C. J., Graham, B. & Boyd, B. J., 2015, In : Drug Delivery and Translational Research. 5, 6, p. 566-574 9 p.

Research output: Contribution to journalArticleResearchpeer-review

10 Citations (Scopus)

Exchange enhanced sensitivity gain for solvent-exchangeable protons in 2D (1)H-(15)N heteronuclear correlation spectra acquired with band-selective pulses

Yao, S., Hinds, M., Murphy, J. & Norton, R., 2011, In : Journal of Magnetic Resonance. 211, 2, p. 243 - 247 5 p.

Research output: Contribution to journalArticleResearchpeer-review

Expansion of a novel lead targeting M. tuberculosis DHFR as antitubercular agents

Sharma, K., Tanwar, O., Deora, G. S., Ali, S., Alam, M. M., Zaman, M. S., Krishna, V. S., Sriram, D. & Akhter, M., 1 Jan 2019, In : Bioorganic and Medicinal Chemistry. 27, 7, p. 1421-1429 9 p.

Research output: Contribution to journalArticleResearchpeer-review

13 Citations (Scopus)

Exploring the chemical space around 8-mercaptoguanine as a route to new inhibitors of the folate biosynthesis enzyme HPPK

Chhabra, S., Barlow, N., Dolezal, O., Hattarki, M., Newman, J., Peat, T., Graham, B. & Swarbrick, J. D., 2013, In : PLoS ONE. 8, 4, 15 p., e59535.

Research output: Contribution to journalArticleResearchpeer-review

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16 Citations (Scopus)

Exposure to 9,10-phenanthrenequinone accelerates malignant progression of lung cancer cells through up-regulation of aldo-keto reductase 1B10

Matsunaga, T., Morikawa, Y., Haga, M., Endo, S., Soda, M., Yamamura, K., El-Kabbani, O., Tajima, K., Ikari, A. & Hara, A., 2014, In : Toxicology and Applied Pharmacology. 278, 2, p. 180 - 189 10 p.

Research output: Contribution to journalArticleResearchpeer-review

20 Citations (Scopus)

Expression, characterization and structure determination of an active site mutant (Glu202-Gln) of mini-stromelysin-1

Steele, D. L., El-Kabbani, O., Dunten, P., Windsor, L. J. J., Kammlott, R. U. U., Crowther, R. L., Michoud, C., Engler, J. A. & Birktoft, J. J., 2000, In : Protein Engineering. p. 397 - 405 9 p.

Research output: Contribution to journalArticleResearchpeer-review

3 Citations (Scopus)

Expression, purification and preliminary crystallographic analysis of human sorbitol dehydrogenase

Darmanin, C., Iwata, T., Carper, D. A., Sparrow, L. G., Chung, R. P-T. & El-Kabbani, O., 2003, In : Acta Crystallographica Section D: Biological Crystallography. D59, p. 558 - 560 3 p.

Research output: Contribution to journalArticleResearchpeer-review

15 Citations (Scopus)

Expression and isotopic labelling of the potassium channel blocker ShK toxin as a thioredoxin fusion protein in bacteria

Chang, S. C., Galea, C., Leung, E. W. W., Tajhya, R. B., Beeton, C., Pennington, M. W. & Norton, R. S., 2012, In : Toxicon : official journal of the International Society on Toxinology. 60, 5, p. 840 - 850 11 p.

Research output: Contribution to journalArticleResearchpeer-review

8 Citations (Scopus)

Extending the Excitation Wavelength of Potential Photosensitizers via Appendage of a Kinetically Stable Terbium(III) Macrocyclic Complex for Applications in Photodynamic Therapy

Ung, P., Clerc, M., Huang, H., Qiu, K., Chao, H., Seitz, M., Boyd, B. J., Graham, B. & Gasser, G., 17 Jul 2017, In : Inorganic Chemistry. 56, 14, p. 7960-7974 15 p.

Research output: Contribution to journalArticleResearchpeer-review

26 Citations (Scopus)

Extracellular loop 2 of the adenosine A1 receptor has a key role in orthosteric ligand affinity and agonist efficacy

Nguyen, A. T. N., Baltos, J-A., Thomas, T., Nguyen, T. D., Lopez Munoz, L., Gregory, K. J., White, P. J., Sexton, P. M., Christopoulos, A. & May, L. T., 1 Dec 2016, In : Molecular Pharmacology. 90, 6, p. 703-714 12 p.

Research output: Contribution to journalArticleResearchpeer-review

15 Citations (Scopus)

Facile, divergent route to bis-Zn(II)dipicolylamine type chemosensors for pyrophosphate

Pathberiya, L. G., Barlow, N., Nguyen, T. B. T., Graham, B. & Tuck, K. L., 2012, In : Tetrahedron. 68, 46, p. 9435 - 9439 5 p.

Research output: Contribution to journalArticleResearchpeer-review

11 Citations (Scopus)

Facile determination of the absolute stereochemistry of hydroxy fatty acids by GC: application to the analysis of fatty acid oxidation by a P450BM3 mutant

Cryle, M. J. & De Voss, J. J., 12 Mar 2007, In : Tetrahedron Asymmetry. 18, 4, p. 547-551 5 p.

Research output: Contribution to journalArticleResearchpeer-review

10 Citations (Scopus)

Facile synthesis and preliminary structure-activity analysis of new sulfonamides against Trypanosoma brucei

Rashad, A. A., Jones, A. J., Avery, V. M., Baell, J. B. & Keller, P. A., 2014, In : ACS Medicinal Chemistry Letters. 5, 5, p. 496 - 500 5 p.

Research output: Contribution to journalArticleResearchpeer-review

47 Citations (Scopus)

Factorizing selectivity determinants of inhibitor binding toward aldose and aldehyde reductases: Structural and thermodynamic properties of the aldose reductase mutant Leu300Pro-fidarestat complex

Petrova, T., Steuber, H., Hazemann, I., Cousido-Siah, A., Mitschler, A., Chung, R. P-T., Oka, M., Klebe, G., El-Kabbani, O., Joachimiak, A. & Podjarny, A. D., 2005, In : Journal of Medicinal Chemistry. 48, 18, p. 5659 - 5665 7 p.

Research output: Contribution to journalArticleResearchpeer-review

1 Citation (Scopus)

Factorizing the role of a critical leucine residue in the binding of substrate to human 20alpha-hydroxysteroid dehydrogenase (AKR1C1): Molecular modeling and kinetic studies of the Leu308Val mutant enzyme

Dhagat, U., Endo, S., Soda, M., Hara, A. & El-Kabbani, O., 2010, In : Bioorganic and Medicinal Chemistry Letters. 20, 17, p. 5274 - 5276 3 p.

Research output: Contribution to journalArticleResearchpeer-review

154 Citations (Scopus)

FAF-Drugs3: a web server for compound property calculation and chemical library design

Lagorce, D., Sperandio, O., Baell, J. B., Miteva, M. A. & Villoutreix, B. O., 1 Jul 2015, In : Nucleic Acids Research. 43, W1, p. W200-W207 8 p.

Research output: Contribution to journalArticleResearchpeer-review

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22 Citations (Scopus)
37 Citations (Scopus)

Fatty acid-binding protein 5 facilitates the blood-brain barrier transport of docosahexaenoic acid

Pan, Y., Scanlon, M., Owada, Y., Yamamoto, Y., Porter, C. J. & Nicolazzo, J., 2015, In : Molecular Pharmaceutics. 12, 12, p. 4375 - 4385 11 p.

Research output: Contribution to journalArticleResearchpeer-review

3 Citations (Scopus)

Fatty Acid-Binding Protein 5 Mediates the Uptake of Fatty Acids, but not Drugs, Into Human Brain Endothelial Cells

Lee, G. S., Pan, Y., Scanlon, M. J., Porter, C. J. H. & Nicolazzo, J. A., Apr 2018, In : Journal of Pharmaceutical Sciences. 107, 4, p. 1185-1193 9 p.

Research output: Contribution to journalArticleResearchpeer-review

8 Citations (Scopus)

Fatty acid binding proteins: potential chaperones of cytosolic drug transport in the enterocyte?

Trevaskis, N., Nguyen, G., Scanlon, M. & Porter, C., 2011, In : Pharmaceutical Research. 28, 9, p. 2176 - 2190 15 p.

Research output: Contribution to journalArticleResearchpeer-review

20 Citations (Scopus)

Fatty acid-binding proteins 1 and 2 differentially modulate the activation of peroxisome proliferator-activated receptor alpha in a ligand-selective manner

Hughes, M. L. R., Liu, B., Halls, M. L., Wagstaff, K. M., Patil, R., Velkov, T., Jans, D. A., Bunnett, N. W., Scanlon, M. & Porter, C. J., 2015, In : Journal of Biological Chemistry. 290, 22, p. 13895 - 13906 12 p.

Research output: Contribution to journalArticleResearchpeer-review

5 Citations (Scopus)

Fatty acid binding proteins expressed at the human blood-brain barrier bind drugs in an isoform-specific manner

Lee, G. S. Y., Kappler, K., Porter, C. J., Scanlon, M. & Nicolazzo, J., 2015, In : Pharmaceutical Research. 32, 10, p. 3432 - 3446 15 p.

Research output: Contribution to journalArticleResearchpeer-review

16 Citations (Scopus)

Flipped classroom implementation: A case report of two higher education institutions in the United States and Australia

McLaughlin, J. E., White, P. J., Khanova, J. & Yuriev, E., 2016, In : Computers in the Schools. 33, 1, p. 24-37 14 p.

Research output: Contribution to journalArticleResearchpeer-review

12 Citations (Scopus)

Fluorescent diphenylphosphonate-based probes for detection of serine protease activity during inflammation

Edgington-Mitchell, L. E., Barlow, N., Aurelio, L., Samha, A., Szabo, M., Graham, B. & Bunnett, N., 15 Jan 2017, In : Bioorganic and Medicinal Chemistry Letters. 27, 2, p. 254-260 7 p.

Research output: Contribution to journalArticleResearchpeer-review

5 Citations (Scopus)

Fluorescently Labeled Morphine Derivatives for Bioimaging Studies

Lam, R., Gondin, A. B., Canals, M., Kellam, B., Briddon, S. J., Graham, B. & Scammells, P. J., 8 Feb 2018, In : Journal of Medicinal Chemistry. 61, 3, p. 1316-1329 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Folate Biosynthesis - Reappraisal of Old and Novel Targets in the Search for New Antimicrobials

Swarbrick, J. D., Iliades, P., Simpson, J. S. & Macreadie, I., 2008, In : The Open Enzyme Inhibition Journal. 1, 0, p. 12 - 33 22 p.

Research output: Contribution to journalArticleResearchpeer-review

Formation of Highly Substituted Indenes through Acid Promoted Cyclodehydration with Nucleophile Incorporation

Dillon, A. S., Kerr, D. J. & Flynn, B. L., 1 Mar 2019, In : Journal of Organic Chemistry. 84, 5, p. 2756-2767 12 p.

Research output: Contribution to journalArticleResearchpeer-review

904 Citations (Scopus)

Formation of Secondary Organic Aerosols Through Photooxidation of Isoprene

Graham, B., Claeys, M., Vas, G., Wang, W., Vermeylen, R., Pashynska, V., Cafmeyer, J., Guyon, P., Andreae, M. O., Artaxo, P. & Maenhaut, W., 2004, In : Science. 303, p. 1173 - 1176 4 p.

Research output: Contribution to journalArticleResearchpeer-review

26 Citations (Scopus)

Fragment-based design of ligands targeting a novel site on the integrase enzyme of human immunodeficiency virus 1

Wielens, J., Headey, S., Deadman, J., Rhodes, D., Le, G., Parker, M., Chalmers, D. & Scanlon, M., 2011, In : ChemMedChem. 6, 4, p. 258 - 261 4 p.

Research output: Contribution to journalArticleResearchpeer-review

5 Citations (Scopus)

Fragment-based discovery of inhibitors of the bacterial DnaG-SSB interaction

Chilingaryan, Z., Headey, S. J., Lo, A. T. Y., Xu, Z. Q., Otting, G., Dixon, N. E., Scanlon, M. J. & Oakley, A. J., 1 Mar 2018, In : Antibiotics. 7, 1, p. 1-12 12 p., 14.

Research output: Contribution to journalArticleResearchpeer-review

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5 Citations (Scopus)

Fragment based strategies for discovery of novel HIV-1 reverse transcriptase and integrase inhibitors

Latham, C. F., La, J., Tinetti, R. N., Chalmers, D. K. & Tachedjian, G., 2016, In : Current Topics in Medicinal Chemistry. 16, 10, p. 1135-1153 19 p.

Research output: Contribution to journalArticleResearchpeer-review