Research Output 1977 2019

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2014
2 Citations (Scopus)

A new methodology for the synthesis of 3-amino-1H-indole-2-carboxylates

Harjani, J. R., Tang, A. X., Norton, R. S. & Baell, J. B., 2014, In : Tetrahedron. 70, 43, p. 8047 - 8055 9 p.

Research output: Contribution to journalArticleResearchpeer-review

50 Citations (Scopus)

A non-fullerene electron acceptor based on fluorene and diketopyrrolopyrrole building blocks for solution-processable organic solar cells with an impressive open-circuit voltage

Patil, H., Wang, X., Gupta, A., Chellappan, V., Bilic, A., Sonar, P., Rananaware, A., Bhosale, S. V. & Bhosale, S. V., 2014, In : Physical Chemistry Chemical Physics. 16, 43, p. 23837 - 23842 6 p.

Research output: Contribution to journalArticleResearchpeer-review

3 Citations (Scopus)

Antibody recognition of Shiga toxins (Stxs): Computational identification of the epitopes of Stx2 subunit A to the antibodies 11E10 and S2C4

Jiao, Y., Legge, F. S., Zeng, X., Treutlein, H. R. & Zeng, J., 2014, In : PLoS ONE. 9, 2, 12 p., e88191.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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39 Citations (Scopus)

A potent and Kv1.3-selective analogue of the scorpion toxin HsTX1 as a potential therapeutic for autoimmune diseases

Rashid, H., Huq, R., Tanner, M. R., Chhabra, S., Khoo, K. K., Estrada, R., Dhawan, V., Chauhan, S., Pennington, M. W., Beeton, C., Kuyucak, S. & Norton, R. S., 2014, In : Scientific Reports. 4, 4509, p. 1 - 9 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
14 Citations (Scopus)

A potent cyclic peptide targeting SPSB2 protein as a potential anti-infective agent

Yap, B. K., Leung, E. W. W., Yagi, H., Galea, C., Chhabra, S., Chalmers, D. K., Nicholson, S. E., Thompson, P. & Norton, R. S., 2014, In : Journal of Medicinal Chemistry. 57, 16, p. 7006 - 7015 10 p.

Research output: Contribution to journalArticleResearchpeer-review

50 Citations (Scopus)

A secondary mode of action of polymyxins against Gram-negative bacteria involves the inhibition of NADH-quinone oxidoreductase activity

Deris, Z. Z., Akter, J., Sivanesan, S., Roberts, K. D., Thompson, P., Nation, R. L., Li, J. & Velkov, T., 2014, In : Journal of Antibiotics. 67, 2, p. 147 - 151 5 p.

Research output: Contribution to journalArticleResearchpeer-review

3 Citations (Scopus)

Assignments of human integrin a1I domain in the apo and Mg2+ bound states

Chin, Y. K-Y., Headey, S. J., Mohanty, B., Emsley, J., Simpson, J. S. & Scanlon, M., 2014, In : Biomolecular NMR Assignments. 8, 1, p. 117 - 121 5 p.

Research output: Contribution to journalArticleResearchpeer-review

A thrombopoietin antagonist is capable of affecting stem and progenitor cells of patients with myelofibrosis

Wang, X., Haylock, D., Hu, C. S., Mosoyan, G., Winkler, D. A. & Hoffman, R., 2014, In : Blood. 124, 21, p. 819 1 p.

Research output: Contribution to journalArticleOther

5 Citations (Scopus)

ATP sensitive bi-quinoline activator of the AMP-activated protein kinase

Scott, J. W., Oakhill, J. S., Ling, N. X. Y., Langendorf, C. G., Foitzik, R., Kemp, B. E. & Issinger, O-G., 2014, In : Biochemical and Biophysical Research Communications. 443, 2, p. 435 - 440 6 p.

Research output: Contribution to journalArticleResearchpeer-review

7 Citations (Scopus)

Bacterial fatty acid synthesis: Effect of Tween 80 on antibiotic potency against Streptococcus agalactiae and methicillin-resistant Staphylococcus aureus

Krsta, D., Ku, K. U. C., Crosby, I. T., Capuano, B. & Manallack, D. T., 2014, In : Anti-Infective Agents. 12, 1, p. 80 - 84 5 p.

Research output: Contribution to journalArticleResearchpeer-review

18 Citations (Scopus)

Beyond loss of frataxin: The complex molecular pathology of friedreich ataxia

Evans-Galea, M. V., Lockhart, P. J., Galea, C., Hannan, A. J. & Delatycki, M., 2014, In : Discovery Medicine. 17, 91, p. 25 - 35 11 p.

Research output: Contribution to journalArticleResearchpeer-review

72 Citations (Scopus)

Biased agonism at G protein-coupled receptors: The promise and the challenges - A medicinal chemistry perspective

Shonberg, J., Lopez Munoz, L., Scammells, P. J., Christopoulos, A., Capuano, B. & Lane, J. R. D., 2014, In : Medicinal Research Reviews. 34, 6, p. 1286 - 1330 45 p.

Research output: Contribution to journalArticleResearchpeer-review

26 Citations (Scopus)

Binding mode of the activity-modulating C-terminal segment of NS2B to NS3 in the dengue virus NS2B-NS3 protease

de la Cruz, L., Chen, W-N., Graham, B. & Otting, G., 2014, In : FEBS Journal. 281, 6, p. 1517 - 1533 17 p.

Research output: Contribution to journalArticleResearchpeer-review

13 Citations (Scopus)

Biomolecule detection in porous silicon based microcavities via europium luminescence enhancement

Aisyiyah, J. S. N., Du, Z., Mcinnes, S. J. P., Ung, P., Graham, B., Plush, S. E. & Voelcker, N., 2014, In : Journal of Materials Chemistry B. 2, 44, p. 7694 - 7703 10 p.

Research output: Contribution to journalArticleResearchpeer-review

21 Citations (Scopus)

Calcium is the switch in the moonlighting dual function of the ligand-activated receptor kinase phytosulfokine receptor 1

Muleya, V., Wheeler, J., Ruzvidzo, O., Freihat, L., Manallack, D. T., Gehring, C. A. & Irving, H. R., 2014, In : Cell Communication and Signaling. 12, p. 1 - 5 5 p., 60.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
9 Citations (Scopus)

Characterization of two distinct modes of drug binding to human intestinal fatty acid binding protein

Patil, R., Laguerre, A. K., Wielens, J., Headey, S. J., Williams, M., Hughes, M. L. R., Mohanty, B., Porter, C. J. & Scanlon, M., 2014, In : ACS Chemical Biology. 9, 11, p. 2526 - 2534 9 p.

Research output: Contribution to journalArticleResearchpeer-review

10 Citations (Scopus)

Cloning and characterization of four rabbit aldo-keto reductases featuring broad substrate specificity for xenobiotic and endogenous carbonyl compounds: Relationship with multiple forms of drug ketone reductases

Endo, S., Matsunaga, T., Arai, Y., Ikari, A., Tajima, K., El-Kabbani, O., Yamano, S., Hara, A. & Kitade, Y., 2014, In : Drug Metabolism and Disposition. 42, 4, p. 803 - 812 10 p.

Research output: Contribution to journalArticleResearchpeer-review

12 Citations (Scopus)

Comparison of moonlighting guanylate cyclases: Roles in signal direction?

Freihat, L., Muleya, V., Manallack, D. T., Wheeler, J. & Irving, H. R., 2014, In : Biochemical Society Transactions. 42, p. 1773 - 1779 7 p.

Research output: Contribution to journalArticleResearchpeer-review

18 Citations (Scopus)

Computational approaches for designing potent and selective analogs of peptide toxins as novel therapeutics

Kuyucak, S. & Norton, R. S., 2014, In : Future Medicinal Chemistry. 6, 15, p. 1645 - 1658 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
6 Citations (Scopus)

Conformational flexibility in the binding surface of the potassium channel blocker ShK

Sher, I., Chang, S. J., Li, Y., Chhabra, S., Palmer III, A. G., Norton, R. S. & Chill, J., 2014, In : ChemBioChem. 15, 16, p. 2402 - 2410 9 p.

Research output: Contribution to journalArticleResearchpeer-review

66 Citations (Scopus)

Conotoxin gene superfamilies

Robinson, S. & Norton, R. S., 2014, In : Marine Drugs. 12, 12, p. 6058 - 6101 44 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
21 Citations (Scopus)

Contrasting effects of nanoparticle binding on protein denaturation

Chen, P., Seabrook, S. A., Epa, V. C., Kurabayashi, K., Barnard, A. S., Winkler, D. A., Kirby, J. K. & Ke, P. C., 2014, In : Journal of Physical Chemistry C. 118, 38, p. 22069 - 22078 10 p.

Research output: Contribution to journalArticleResearchpeer-review

7 Citations (Scopus)

Convergent access to polycyclic cyclopentanoids from a,b-unsaturated acid chlorides and alkynes through a reductive coupling, Nazarov cyclization sequence

Chaplin, J. H., Jackson, K. E., White, J. & Flynn, B. L., 2014, In : Journal of Organic Chemistry. 79, 8, p. 3659 - 3664 6 p.

Research output: Contribution to journalArticleResearchpeer-review

5 Citations (Scopus)

Design, synthesis and evaluation of N6-substituted 2-aminoadenosine-5'-N-methylcarboxamides as A3 adenosine receptor agonists

Devine, S., May, L. T. & Scammells, P. J., 2014, In : MedChemComm. 5, 2, p. 192 - 196 5 p.

Research output: Contribution to journalArticleResearchpeer-review

8 Citations (Scopus)

Development of a photoactivatable allosteric ligand for the M1 muscarinic acetylcholine receptor

Davie, B. J., Sexton, P., Capuano, B., Christopoulos, A. & Scammells, P. J., 2014, In : ACS Chemical Neuroscience. 5, 10, p. 902 - 907 6 p.

Research output: Contribution to journalArticleResearchpeer-review

32 Citations (Scopus)

Dicarba analogues of a-conotoxin RgIA. Structure, stability, and activity at potential pain targets

Chhabra, S., Belgi, A., Bartels, P., Van Lierop, B. J., Robinson, S., Kompella, S. N., Hung, A., Callaghan, B., Adams, D. J., Robinson, A. J. & Norton, R. S., 2014, In : Journal of Medicinal Chemistry. 57, 23, p. 9933 - 9944 12 p.

Research output: Contribution to journalArticleResearchpeer-review

22 Citations (Scopus)

Digestion of phospholipids after secretion of bile into the duodenum changes the phase behavior of bile components

Birru, W. A., Warren, D., Ibrahim, A. M. H., Williams, H. D., Benameur, H., Porter, C. J., Chalmers, D. K. & Pouton, C. W., 2014, In : Molecular Pharmaceutics. 11, 8, p. 2825 - 2834 10 p.

Research output: Contribution to journalArticleResearchpeer-review

2 Citations (Scopus)

Discovery of phosphodiesterase-4 inhibitors: Serendipity and rational drug design

Feil, S. C., Holien, J. K., Morton, C. J., Hancock, N. C., Thompson, P. & Parker, M. W., 2014, In : Australian Journal of Chemistry. 67, 12, p. 1780 - 1785 6 p.

Research output: Contribution to journalArticleResearchpeer-review

62 Citations (Scopus)

Diversity of conotoxin gene superfamilies in the venomous snail, Conus victoriae

Robinson, S., Safavi-Hemami, H., McIntosh, L. D., Purcell, A. W., Norton, R. S. & Papenfuss, A. T., 2014, In : PLoS ONE. 9, e87648, p. 1 - 13 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
14 Citations (Scopus)

Domain structure and function of matrix metalloprotease 23 (MMP23): Role in potassium channel trafficking

Galea, C., Nguyen, H. M., Chandy, G. K., Smith, B. J. & Norton, R. S., 2014, In : Cellular and Molecular Life Sciences. 71, 7, p. 1191 - 1210 20 p.

Research output: Contribution to journalArticleResearchpeer-review

17 Citations (Scopus)

EGF receptor-targeting peptide conjugate incorporating a near-IR fluorescent dye and a novel 1,4,7-triazacyclononane-based 64Cu(II) chelator assembled via click chemistry

Viehweger, K., Barbaro, L., Pombo-Garcia, K., Joshi, T., Geipel, G., Steinbach, J., Stephan, H., Spiccia, L. & Graham, B., 2014, In : Bioconjugate Chemistry. 25, 5, p. 1011 - 1022 12 p.

Research output: Contribution to journalArticleResearchpeer-review

37 Citations (Scopus)

Enhanced cytotoxicity through conjugation of a "clickable" luminescent Re(I) complex to a cell-penetrating lipopeptide

Leonidova, A., Pierroz, V., Adams, L. A., Barlow, N., Ferrari, S., Graham, B. & Gasser, G. A., 2014, In : ACS Medicinal Chemistry Letters. 5, 7, p. 809 - 814 6 p.

Research output: Contribution to journalArticleResearchpeer-review

16 Citations (Scopus)

Exposure to 9,10-phenanthrenequinone accelerates malignant progression of lung cancer cells through up-regulation of aldo-keto reductase 1B10

Matsunaga, T., Morikawa, Y., Haga, M., Endo, S., Soda, M., Yamamura, K., El-Kabbani, O., Tajima, K., Ikari, A. & Hara, A., 2014, In : Toxicology and Applied Pharmacology. 278, 2, p. 180 - 189 10 p.

Research output: Contribution to journalArticleResearchpeer-review

10 Citations (Scopus)

Facile synthesis and preliminary structure-activity analysis of new sulfonamides against Trypanosoma brucei

Rashad, A. A., Jones, A. J., Avery, V. M., Baell, J. B. & Keller, P. A., 2014, In : ACS Medicinal Chemistry Letters. 5, 5, p. 496 - 500 5 p.

Research output: Contribution to journalArticleResearchpeer-review

9 Citations (Scopus)

Getting to the source: Selective drug targeting of cancer stem cells

Ismail, F. & Winkler, D. A., 2014, In : ChemMedChem. 9, 5, p. 885-898 14 p.

Research output: Contribution to journalArticleResearchpeer-review

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10 Citations (Scopus)

Highly functionalized and potent antiviral cyclopentane derivatives formed by a tandem process consisting of organometallic, transition-metal-catalyzed, and radical reaction steps

Jagtap, P. R., Ford, L., Deister, E., Pohl, R., Císařová, I., Hodek, J., Weber, J., Mackman, R., Bahador, G. & Jahn, U., 11 Aug 2014, In : Chemistry - A European Journal. 20, 33, p. 10298-10304 7 p.

Research output: Contribution to journalArticleResearchpeer-review

13 Citations (Scopus)

Homology modeling of human muscarinic acetylcholine receptors

Thomas, T., McLean, K. C., McRobb, F. M., Manallack, D. T., Chalmers, D. K. & Yuriev, E., 2014, In : Journal of Chemical Information and Modeling. 54, 1, p. 243 - 253 11 p.

Research output: Contribution to journalArticleResearchpeer-review

12 Citations (Scopus)

Hypotensive effects of ghrelin receptor agonists mediated through a novel receptor

Callaghan, B., Kosari, S., Pustovit, R. V., Sartor, D. M., Ferens, D. M., Ban, K., Baell, J. B., Nguyen, T. V., Rivera, L. R., Brock, J. A. & Furness, J. B., 2014, In : British Journal of Pharmacology. 171, 5, p. 1275 - 1286 12 p.

Research output: Contribution to journalArticleResearchpeer-review

12 Citations (Scopus)

Induction of aldo-keto reductases (AKR1C1 and AKR1C3) abolishes the efficacy of daunorubicin chemotherapy for leukemic U937 cells

Matsunaga, T., Yamaguchi, A., Morikawa, Y., Kezuka, C., Takazawa, H., Endo, S., El-Kabbani, O., Tajima, K., Ikari, A. & Hara, A., 2014, In : Anti-Cancer Drugs. 25, 8, p. 868 - 877 10 p.

Research output: Contribution to journalArticleResearchpeer-review

22 Citations (Scopus)

Intramolecular binding mode of the C-terminus of Escherichia coli single-stranded DNA binding protein determined by nuclear magnetic resonance spectroscopy

Shishmarev, D., Wang, Y., Mason, C. E., Su, X-C., Oakley, A. J., Graham, B., Huber, T., Dixon, N. E. & Otting, G., Feb 2014, In : Nucleic Acids Research. 42, 4, p. 2750-2757 8 p.

Research output: Contribution to journalArticleResearchpeer-review

14 Citations (Scopus)

Investigation of novel ropinirole analogues: Synthesis, pharmacological evaluation and computational analysis of dopamine D2 receptor functionalized congeners and homobivalent ligands

Jorg, M. T., Kaczor, A. A., Mak, F. S., Lee, K. C. K., Poso, A., Miller, N. D., Scammells, P. J. & Capuano, B., 2014, In : MedChemComm. 5, 7, p. 891 - 898 8 p.

Research output: Contribution to journalArticleResearchpeer-review

52 Citations (Scopus)

Ionic liquids provide unique opportunities for oral drug delivery: Structure optimization and in vivo evidence of utility

Williams, H. D., Sahbaz, Y., Ford, L., Nguyen, T-H., Scammells, P. J. & Porter, C. J., 2014, In : Chemical Communications. 50, 14, p. 1688 - 1690 3 p.

Research output: Contribution to journalArticleResearchpeer-review

36 Citations (Scopus)

Kv1.3 channel-blocking immunomodulatory peptides from parasitic worms: Implications for autoimmune diseases

Chhabra, S., Chang, S. J., Nguyen, H. M., Huq, R., Tanner, M. R., Londono, L. M., Estrada, R., Dhawan, V., Chauhan, S., Upadhyay, S. K., Gindin, M., Hotez, P. J., Valenzuela, J. G., Mohanty, B., Swarbrick, J. D., Wulff, H., Iadonato, S. P., Gutman, G. A., Beeton, C., Pennington, M. W. & 2 others, Norton, R. S. & Chandy, G. K., 2014, In : FASEB Journal. 28, p. 3952 - 3964 13 p.

Research output: Contribution to journalArticleResearchpeer-review

26 Citations (Scopus)

Ligand-induced conformational change of Plasmodium falciparum AMA1 detected using 19F NMR

Ge, X., MacRaild, C. A., Devine, S., Debono, C., Wang, G., Scammells, P. J., Scanlon, M., Anders, R. F., Foley, M. & Norton, R. S., 2014, In : Journal of Medicinal Chemistry. 57, 15, p. 6419 - 6427 9 p.

Research output: Contribution to journalArticleResearchpeer-review

90 Citations (Scopus)

Materials for stem cell factories of the future

Celiz, A., Smith, J. G. W., Langer, R. S. M., Anderson, D. G., Winkler, D. A., Barrett, D. A., Davies, M. C., Young, L., Denning, C. & Alexander, M. R., 2014, In : Nature Materials. 13, 6, p. 570 - 579 10 p.

Research output: Contribution to journalArticleResearchpeer-review

File
27 Citations (Scopus)

Mechanistic insights into allosteric structure-function relationships at the M1 muscarinic acetylcholine receptor

Abdul Ridha, A., Lane, J. R. D., Mistry, S. N., Lopez Munoz, L., Sexton, P., Scammells, P. J., Christopoulos, A. & Canals, M., 2014, In : Journal of Biological Chemistry. 289, 48, p. 33701 - 33711 11 p.

Research output: Contribution to journalArticleResearchpeer-review

41 Citations (Scopus)

Modelling and predicting the biological effects of nanomaterials

Winkler, D. A., Burden, F. R., Yan, B., Weissleder, R., Tassa, C., Shaw, S. & Epa, V. C., 2014, In : SAR and QSAR in Environmental Research. 25, 2, p. 161 - 172 12 p.

Research output: Contribution to journalArticleResearchpeer-review

File
26 Citations (Scopus)

Modelling and prediction of bacterial attachment to polymers

Epa, V. C., Hook, A. L., Chang, C., Yang, J., Langer, R. S. M., Anderson, D. G., Williams, P. M., Davies, M. C., Alexander, M. R. & Winkler, D. A., 2014, In : Advanced Functional Materials. 24, 14, p. 2085 - 2093 9 p.

Research output: Contribution to journalArticleResearchpeer-review

37 Citations (Scopus)

Molecular determinants of allosteric modulation at the M1 muscarinic acetylcholine receptor

Abdul Ridha, A., Lopez, L., Keov, P., Thal, D., Mistry, S. N., Sexton, P., Lane, J. R. D., Canals, M. & Christopoulos, A., 2014, In : Journal of Biological Chemistry. 289, 9, p. 6067 - 6079 13 p.

Research output: Contribution to journalArticleResearchpeer-review

10 Citations (Scopus)

Molecular insights into the interaction between Plasmodium falciparum apical membrane antigen 1 and an invasion-inhibitory peptide

Wang, G., MacRaild, C. A., Mohanty, B., Mobli, M., Cowieson, N. P., Anders, R. F., Simpson, J. S., McGowan, S., Norton, R. S. & Scanlon, M., 2014, In : PLoS ONE. 9, 10, p. 1-12 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access