Research Output 1977 2019

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2014

Discovery of phosphodiesterase-4 inhibitors: Serendipity and rational drug design

Feil, S. C., Holien, J. K., Morton, C. J., Hancock, N. C., Thompson, P. & Parker, M. W., 2014, In : Australian Journal of Chemistry. 67, 12, p. 1780 - 1785 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Diversity of conotoxin gene superfamilies in the venomous snail, Conus victoriae

Robinson, S., Safavi-Hemami, H., McIntosh, L. D., Purcell, A. W., Norton, R. S. & Papenfuss, A. T., 2014, In : PLoS ONE. 9, e87648, p. 1 - 13 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Domain structure and function of matrix metalloprotease 23 (MMP23): Role in potassium channel trafficking

Galea, C., Nguyen, H. M., Chandy, G. K., Smith, B. J. & Norton, R. S., 2014, In : Cellular and Molecular Life Sciences. 71, 7, p. 1191 - 1210 20 p.

Research output: Contribution to journalArticleResearchpeer-review

EGF receptor-targeting peptide conjugate incorporating a near-IR fluorescent dye and a novel 1,4,7-triazacyclononane-based 64Cu(II) chelator assembled via click chemistry

Viehweger, K., Barbaro, L., Pombo-Garcia, K., Joshi, T., Geipel, G., Steinbach, J., Stephan, H., Spiccia, L. & Graham, B., 2014, In : Bioconjugate Chemistry. 25, 5, p. 1011 - 1022 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Enhanced cytotoxicity through conjugation of a "clickable" luminescent Re(I) complex to a cell-penetrating lipopeptide

Leonidova, A., Pierroz, V., Adams, L. A., Barlow, N., Ferrari, S., Graham, B. & Gasser, G. A., 2014, In : A C S Medicinal Chemistry Letters. 5, 7, p. 809 - 814 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Exposure to 9,10-phenanthrenequinone accelerates malignant progression of lung cancer cells through up-regulation of aldo-keto reductase 1B10

Matsunaga, T., Morikawa, Y., Haga, M., Endo, S., Soda, M., Yamamura, K., El-Kabbani, O., Tajima, K., Ikari, A. & Hara, A., 2014, In : Toxicology and Applied Pharmacology. 278, 2, p. 180 - 189 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Facile synthesis and preliminary structure-activity analysis of new sulfonamides against Trypanosoma brucei

Rashad, A. A., Jones, A. J., Avery, V. M., Baell, J. B. & Keller, P. A., 2014, In : A C S Medicinal Chemistry Letters. 5, 5, p. 496 - 500 5 p.

Research output: Contribution to journalArticleResearchpeer-review

Getting to the source: Selective drug targeting of cancer stem cells

Ismail, F. & Winkler, D. A., 2014, In : ChemMedChem. 9, 5, p. 885-898 14 p.

Research output: Contribution to journalArticleResearchpeer-review

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Highly functionalized and potent antiviral cyclopentane derivatives formed by a tandem process consisting of organometallic, transition-metal-catalyzed, and radical reaction steps

Jagtap, P. R., Ford, L., Deister, E., Pohl, R., Císařová, I., Hodek, J., Weber, J., Mackman, R., Bahador, G. & Jahn, U., 11 Aug 2014, In : Chemistry - A European Journal. 20, 33, p. 10298-10304 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Homology modeling of human muscarinic acetylcholine receptors

Thomas, T., McLean, K. C., McRobb, F. M., Manallack, D. T., Chalmers, D. K. & Yuriev, E., 2014, In : Journal of Chemical Information and Modeling. 54, 1, p. 243 - 253 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Hypotensive effects of ghrelin receptor agonists mediated through a novel receptor

Callaghan, B., Kosari, S., Pustovit, R. V., Sartor, D. M., Ferens, D. M., Ban, K., Baell, J. B., Nguyen, T. V., Rivera, L. R., Brock, J. A. & Furness, J. B., 2014, In : British Journal of Pharmacology. 171, 5, p. 1275 - 1286 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Induction of aldo-keto reductases (AKR1C1 and AKR1C3) abolishes the efficacy of daunorubicin chemotherapy for leukemic U937 cells

Matsunaga, T., Yamaguchi, A., Morikawa, Y., Kezuka, C., Takazawa, H., Endo, S., El-Kabbani, O., Tajima, K., Ikari, A. & Hara, A., 2014, In : Anti-Cancer Drugs. 25, 8, p. 868 - 877 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Intramolecular binding mode of the C-terminus of Escherichia coli single-stranded DNA binding protein determined by nuclear magnetic resonance spectroscopy

Shishmarev, D., Wang, Y., Mason, C. E., Su, X-C., Oakley, A. J., Graham, B., Huber, T., Dixon, N. E. & Otting, G., Feb 2014, In : Nucleic Acids Research. 42, 4, p. 2750-2757 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Investigation of novel ropinirole analogues: Synthesis, pharmacological evaluation and computational analysis of dopamine D2 receptor functionalized congeners and homobivalent ligands

Jorg, M. T., Kaczor, A. A., Mak, F. S., Lee, K. C. K., Poso, A., Miller, N. D., Scammells, P. J. & Capuano, B., 2014, In : MedChemComm. 5, 7, p. 891 - 898 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Ionic liquids provide unique opportunities for oral drug delivery: Structure optimization and in vivo evidence of utility

Williams, H. D., Sahbaz, Y., Ford, L., Nguyen, T-H., Scammells, P. J. & Porter, C. J., 2014, In : Chemical Communications. 50, 14, p. 1688 - 1690 3 p.

Research output: Contribution to journalArticleResearchpeer-review

Kv1.3 channel-blocking immunomodulatory peptides from parasitic worms: Implications for autoimmune diseases

Chhabra, S., Chang, S. J., Nguyen, H. M., Huq, R., Tanner, M. R., Londono, L. M., Estrada, R., Dhawan, V., Chauhan, S., Upadhyay, S. K., Gindin, M., Hotez, P. J., Valenzuela, J. G., Mohanty, B., Swarbrick, J. D., Wulff, H., Iadonato, S. P., Gutman, G. A., Beeton, C., Pennington, M. W. & 2 othersNorton, R. S. & Chandy, G. K., 2014, In : FASEB Journal. 28, p. 3952 - 3964 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Ligand-induced conformational change of Plasmodium falciparum AMA1 detected using 19F NMR

Ge, X., MacRaild, C. A., Devine, S., Debono, C., Wang, G., Scammells, P. J., Scanlon, M., Anders, R. F., Foley, M. & Norton, R. S., 2014, In : Journal of Medicinal Chemistry. 57, 15, p. 6419 - 6427 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Materials for stem cell factories of the future

Celiz, A., Smith, J. G. W., Langer, R. S. M., Anderson, D. G., Winkler, D. A., Barrett, D. A., Davies, M. C., Young, L., Denning, C. & Alexander, M. R., 2014, In : Nature Materials. 13, 6, p. 570 - 579 10 p.

Research output: Contribution to journalArticleResearchpeer-review

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Mechanistic insights into allosteric structure-function relationships at the M1 muscarinic acetylcholine receptor

Abdul Ridha, A., Lane, J. R. D., Mistry, S. N., Lopez Munoz, L., Sexton, P., Scammells, P. J., Christopoulos, A. & Canals, M., 2014, In : Journal of Biological Chemistry. 289, 48, p. 33701 - 33711 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Modelling and predicting the biological effects of nanomaterials

Winkler, D. A., Burden, F. R., Yan, B., Weissleder, R., Tassa, C., Shaw, S. & Epa, V. C., 2014, In : SAR and QSAR in Environmental Research. 25, 2, p. 161 - 172 12 p.

Research output: Contribution to journalArticleResearchpeer-review

File

Modelling and prediction of bacterial attachment to polymers

Epa, V. C., Hook, A. L., Chang, C., Yang, J., Langer, R. S. M., Anderson, D. G., Williams, P. M., Davies, M. C., Alexander, M. R. & Winkler, D. A., 2014, In : Advanced Functional Materials. 24, 14, p. 2085 - 2093 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Molecular determinants of allosteric modulation at the M1 muscarinic acetylcholine receptor

Abdul Ridha, A., Lopez, L., Keov, P., Thal, D., Mistry, S. N., Sexton, P., Lane, J. R. D., Canals, M. & Christopoulos, A., 2014, In : Journal of Biological Chemistry. 289, 9, p. 6067 - 6079 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Molecular insights into the interaction between Plasmodium falciparum apical membrane antigen 1 and an invasion-inhibitory peptide

Wang, G., MacRaild, C. A., Mohanty, B., Mobli, M., Cowieson, N. P., Anders, R. F., Simpson, J. S., McGowan, S., Norton, R. S. & Scanlon, M., 2014, In : PLoS ONE. 9, 10, p. 1-12 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Molecular mechanisms of bitopic ligand engagement with the M1 muscarinic acetylcholine receptor

Keov, P., Lopez, L., Devine, S., Valant, C., Lane, J. R. D., Scammells, P. J., Sexton, P. & Christopoulos, A., 2014, In : Journal of Biological Chemistry. 289, 34, p. 23817 - 23837 21 p.

Research output: Contribution to journalArticleResearchpeer-review

Nitric oxide confers cisplatin resistance in human lung cancer cells through upregulation of aldo-keto reductase 1B10 and proteasome

Matsunaga, T., Yamaji, Y., Tomokuni, T., Morita, H., Morikawa, Y., Suzuki, A., Yonezawa, A., Endo, S., Ikari, A., Iguchi, K., El-Kabbani, O., Tajima, K. & Hara, A., 2014, In : Free Radical Research. 48, 11, p. 1371 - 1385 15 p.

Research output: Contribution to journalArticleResearchpeer-review

NMR case study of ropinirole: Concentration-dependent effects of nonexchangeable proton resonances

Jorg, M. T., Headey, S. J., Scammells, P. J. & Capuano, B., 2014, In : Magnetic Resonance in Chemistry. 52, 11, p. 715 - 718 4 p.

Research output: Contribution to journalArticleOtherpeer-review

Pharmacological characterization and chemical fractionation of a liposterolic extract of saw palmetto (Serenoa repens): Effects on rat prostate contractility

Chua, T., Eise, N., Simpson, J. S. & Ventura, S., 2014, In : Journal of Ethnopharmacology. 152, 2, p. 283 - 291 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Probing AKR1C30 and AKR1C31 with site-directed mutagenesis: Identifying the roles of residues 54 and 56 in the binding of substrates and inhibitors

Endo, S., Arai, Y., Matsunaga, T., Ikari, A., El-Kabbani, O., Hara, A. & Kitade, Y., 2014, In : Biological & Pharmaceutical Bulletin. 37, 11, p. 1848 - 1852 5 p.

Research output: Contribution to journalArticleResearchpeer-review

Probing the penetration of antimicrobial polymyxin lipopeptides into gram-negative bacteria

Deris, Z. Z., Swarbrick, J. D., Roberts, K. D., Azad, M. A. K., Akter, J., Horne, A. S., Nation, R. L., Rogers, K. L., Thompson, P., Velkov, T. & Li, J., 2014, In : Bioconjugate Chemistry. 25, 4, p. 750 - 760 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Pyridyl benzamides as a novel class of potent inhibitors for the kinetoplastid Trypanosoma brucei

Ferrins, L., Gazdik, M., Rahmani, R. S., Varghese, S., Sykes, M. L., Jones, A. J., Avery, V. M., White, K. L., Ryan, E., Charman, S. A., Kaiser, M., Bergstrom, C. A. S. & Baell, J. B., 2014, In : Journal of Medicinal Chemistry. 57, 15, p. 6393 - 6402 10 p.

Research output: Contribution to journalArticleResearchpeer-review

RASP: Rapid and robust backbone chemical shift assignments from protein structure

MacRaild, C. A. & Norton, R. S., 2014, In : Journal of Biomolecular NMR. 58, 3, p. 155 - 163 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Structural basis of nSH2 regulation and lipid binding in PI3Ka

Miller, M. S., Schmidt-Kittler, O., Bolduc, D. M., Brower, E. T., Chaves-Moreira, D., Allaire, M., Kinzler, K. W., Jennings, I., Thompson, P., Cole, P. A., Amzel, L. M., Vogelstein, B. & Gabelli, S. B., 2014, In : Oncotarget. 5, 14, p. 5198 - 5208 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Structure-activity relationships of privileged structures lead to the discovery of novel biased ligands at the dopamine D2 receptor

Szabo, M., Klein Herenbrink, C., Christopoulos, A., Lane, J. R. D. & Capuano, B., 2014, In : Journal of Medicinal Chemistry. 57, 11, p. 4924 - 4939 16 p.

Research output: Contribution to journalArticleResearchpeer-review

Structure and dynamics of apical membrane antigen 1 from Plasmodium falciparum FVO

Lim, S. S., Yang, W. W., Krishnarjuna, B., Kannan Sivaraman, K., Chandrashekaran, I. R., Kass, I., MacRaild, C. A., Devine, S., Debono, C., Anders, R. F., Scanlon, M., Scammells, P. J., Norton, R. S. & McGowan, S., 2014, In : Biochemistry. 53, 46, p. 7310 - 7320 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Structure and function of mu-conotoxins, peptide-based sodium channel blockers with analgesic activity

Green, B. R., Bulaj, G. & Norton, R. S., 2014, In : Future Medicinal Chemistry. 6, 15, p. 1677 - 1698 22 p.

Research output: Contribution to journalArticleResearchpeer-review

Structure-based design and development of functionalized mercaptoguanine derivatives as inhibitors of the folate biosynthesis pathway enzyme 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase from Staphylococcus aureus

Dennis, M., Chhabra, S., Wang, Z-C., Debono, A. J., Dolezal, O., Newman, J., Pitcher, N. P., Rahmani, R. S., Cleary, B., Barlow, N., Hattarki, M., Graham, B., Peat, T. S., Baell, J. B. & Swarbrick, J. D., 2014, In : Journal of Medicinal Chemistry. 57, 22, p. 9612 - 9626 15 p.

Research output: Contribution to journalArticleResearchpeer-review

Structure of the chicken CD3epsilon/delta/gamma heterodimer and its assembly with the alphabetaT cell receptor

Berry, R., Headey, S. J., Call, M. J., McCluskey, J., Tregaskes, C. A., Kaufman, J., Koh, R., Scanlon, M., Call, M. E. & Rossjohn, J., 2014, In : Journal of Biological Chemistry. 289, 12, p. 8240 - 8251 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Synthesis, structure-activity relationships and brain uptake of a novel series of benzopyran inhibitors of insulin-regulated aminopeptidase

Mountford, S. J., Albiston, A. L., Charman, W. N., Ng, L., Holien, J. K., Parker, M. W., Nicolazzo, J., Thompson, P. & Chai, S. Y., 2014, In : Journal of Medicinal Chemistry. 57, 4, p. 1368 - 1377 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Synthesis of thieno-fused heterocycles through reiterative iodocyclization

Aurelio, L., Volpe, R., Halim, R., Scammells, P. J. & Flynn, B. L., 2014, In : Advanced Synthesis and Catalysis. 356, 9, p. 1974 - 1978 5 p.

Research output: Contribution to journalArticleResearchpeer-review

Synthetic routes to the Neuropeptide Y Y1 receptor antagonist 1229U91 and related analogues for SAR studies and cell-based imaging

Mountford, S. J., Liu, M., Zhang, L., Groenen, M., Herzog, H., Holliday, N. D. & Thompson, P., 2014, In : Organic and Biomolecular Chemistry. 12, 20, p. 3271 - 3281 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Targeted delivery of a model immunomodulator to the lymphatic system: Comparison of alkyl ester versus triglyceride mimetic lipid prodrug strategies

Han, S., Quach, T., Hu, L., Wahab, A., Charman, W. N., Stella, V. J., Trevaskis, N., Simpson, J. S. & Porter, C. J., 2014, In : Journal of Controlled Release. 177, 1, p. 1 - 10 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Teaching 'old' polymyxins new tricks: New-generation lipopeptides targeting gram-negative 'superbugs'

Velkov, T., Roberts, K. D., Nation, R. L., Wang, J., Thompson, P. & Li, J., 2014, In : ACS Chemical Biology. 9, 5, p. 1172 - 1177 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

The dengue virus NS2B-NS3 protease retains the closed conformation in the complex with BPTI

Chen, W-N., Loscha, K. V., Nitsche, C., Graham, B. & Otting, G., 2014, In : FEBS Letters. 588, 14, p. 2206 - 2211 6 p.

Research output: Contribution to journalArticleResearchpeer-review

The dopamine D2 and adenosine A2A receptors: Past, present and future trends for the treatment of parkinson's disease

Jorg, M. T., Scammells, P. J. & Capuano, B., 2014, In : Current Medicinal Chemistry. 21, 27, p. 3188 - 3210 23 p.

Research output: Contribution to journalArticleResearchpeer-review

The drug vehicle and solvent N-Methylpyrrolidone is an immunomodulator and antimyeloma compound

Shortt, J., Hsu, A. K., Martin, B. P., Doggett, K., Matthews, G. M., Doyle, M. A., Ellul, J., Jockel, T. E., Andrews, D. M. K., Hogg, S. J., Reitsma, A. J., Faulkner, D., Bergsagel, P. L., Chesi, M., Heath, J. K., Denny, W. A., Thompson, P., Neeson, P., Ritchie, D., McArthur, G. A. & 1 othersJohnstone, R. W., 2014, In : Cell Reports. 7, 4, p. 1009 - 1019 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

The NBOMe hallucinogenic drug series: Patterns of use, characteristics of users and self-reported effects in a large international sample

Lawn, W., Barratt, M. J., Williams, M., Horne, A. & Winstock, A. R., 2014, In : Journal of Psychopharmacology. 28, 8, p. 780 - 788 9 p.

Research output: Contribution to journalArticleResearchpeer-review

The role of oxidoreductases in determining the function of the neisserial lipid A phosphoethanolamine transferase required for resistance to polymyxin

Piek, S., Wang, Z., Ganguly, J., Lakey, A. M., Bartley, S. N., Mowlaboccus, S., Anandan, A., Stubbs, K., Scanlon, M., Vrielink, A., Azadi, P., Carlson, R. W. & Kahler, C. M., 2014, In : PLoS ONE. 9, 9, 12 p., e106513.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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The synthesis and biological evaluation of multifunctionalised derivatives of noscapine as cytotoxic agents

Debono, A. J., Mistry, S. J., Xie, A., Muthiah, D., Phillips, J. R., Ventura, S., Callaghan, R., Pouton, C. W., Capuano, B. & Scammells, P. J., 2014, In : ChemMedChem. 9, 2, p. 399 - 410 12 p.

Research output: Contribution to journalArticleResearchpeer-review