Research Output 1977 2019

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2015
12 Citations (Scopus)

N-terminally extended analogues of the K+ channel toxin from Stichodactyla helianthus as potent and selective blockers of the voltage-gated potassium channel Kv1.3

Chang, S. C., Huq, R., Chhabra, S., Beeton, C., Pennington, M. W., Smith, B. J. & Norton, R. S., 2015, In : FEBS Journal. 282, 12, p. 2247-2259 13 p.

Research output: Contribution to journalArticleResearchpeer-review

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17 Citations (Scopus)

O-tert-butyltyrosine, an NMR tag for high-molecular-weight systems and measurements of submicromolar ligand binding affinities

Chen, W-N., Kuppan, K. V., Lee, M. D., Jaudzems, K., Huber, T. & Otting, G., 2015, In : Journal of the American Chemical Society. 137, 13, p. 4581-4586 6 p.

Research output: Contribution to journalArticleResearchpeer-review

18 Citations (Scopus)

Probing enzyme-nanoparticle interactions using combinatorial gold nanoparticle libraries

Liu, Y., Winkler, D. A., Epa, V. C., Zhang, B. & Yan, B., 2015, In : Nano Research. 8, 4, p. 1293-1308 16 p.

Research output: Contribution to journalArticleResearchpeer-review

10 Citations (Scopus)

Profiling the role of deacylation-reacylation in the lymphatic transport of a triglyceride-mimetic prodrug

Han, S., Hu, L., Quach, T., Simpson, J. S., Trevaskis, N. & Porter, C. J., 2015, In : Pharmaceutical Research. 32, 5, p. 1830-1844 15 p.

Research output: Contribution to journalArticleResearchpeer-review

31 Citations (Scopus)

Progress toward the development of noscapine and derivatives as anticancer agents

DeBono, A., Capuano, B. & Scammells, P. J., 2015, In : Journal of Medicinal Chemistry. 58, 15, p. 5699-5727 29 p.

Research output: Contribution to journalArticleResearchpeer-review

50 Citations (Scopus)

Promiscuous 2-aminothiazoles (PrATs): a frequent hitting scaffold

Devine, S., Mulcair, M., Debono, C., Leung, E. W. W., Nissink, J. W. M., Lim, S. S., Chandrashekaran, I. R., Vazirani, M., Mohanty, B., Simpson, J. S., Baell, J. B., Scammells, P. J., Norton, R. S. & Scanlon, M., 2015, In : Journal of Medicinal Chemistry. 58, 3, p. 1205 - 1214 10 p.

Research output: Contribution to journalArticleResearchpeer-review

7 Citations (Scopus)

Proof of concept study for designed multiple ligands targeting the dopamine D2, serotonin 5-HT2A, and muscarinic M1 acetylcholine receptors

Szabo, M., Lim, H. D., Klein Herenbrink, C., Christopoulos, A., Lane, J. R. D. & Capuano, B., 2015, In : Journal of Medicinal Chemistry. 58, 3, p. 1550 - 1555 6 p.

Research output: Contribution to journalArticleResearchpeer-review

7 Citations (Scopus)

Propargyloxyproline regio- and stereoisomers for click-conjugation of peptides: synthesis and application in linear and cyclic peptides

Northfield, S. E., Mountford, S. J., Wielens, J., Liu, M., Zhang, L., Herzog, H., Holliday, N. D., Scanlon, M., Parker, M. W., Chalmers, D. K. & Thompson, P., 2015, In : Australian Journal of Chemistry. 68, 9, p. 1365-1372 8 p.

Research output: Contribution to journalArticleResearchpeer-review

5 Citations (Scopus)

Protective roles of aldo-keto reductase 1B10 and autophagy against toxicity induced by p-quinone metabolites of tert-butylhydroquinone in lung cancer A549 cells

Endo, S., Nishiyama, A., Suyama, M., Takemura, M., Soda, M., Chen, H., Tajima, K., El-Kabbani, O., Bunai, Y., Hara, A., Matsunaga, T. & Ikari, A., 2015, In : Chemico-Biological Interactions. 234, p. 282-289 8 p.

Research output: Contribution to journalArticleResearchpeer-review

38 Citations (Scopus)

Protein conformation by EPR spectroscopy using gadolinium tags clicked to genetically encoded p-azido-L-phenylalanine

Abdelkader, E. H., Feintuch, A., Yao, X., Adams, L. A., Aurelio, L., Graham, B., Goldfarb, D. & Otting, G., 2015, In : Chemical Communications. 51, 88, p. 15898-15901 4 p.

Research output: Contribution to journalArticleResearchpeer-review

14 Citations (Scopus)

Real-time examination of aminoglycoside activity towards bacterial mimetic membranes using Quartz Crystal Microbalance with Dissipation monitoring (QCM-D)

Joshi, T., Voo, Z. X., Graham, B., Spiccia, L. & Martin, L. L., 2015, In : Biochimica et Biophysica Acta - Biomembranes. 1848, 2, p. 385 - 391 7 p.

Research output: Contribution to journalArticleResearchpeer-review

13 Citations (Scopus)

Regio- and stereoselective iodoacyloxylations of alkynes

Priebbenow, D., Gable, R. W. & Baell, J. B., 2015, In : Journal of Organic Chemistry. 80, 9, p. 4412 - 4418 7 p.

Research output: Contribution to journalArticleResearchpeer-review

21 Citations (Scopus)

Relevance vector machines: sparse classification methods for QSAR

Burden, F. R. & Winkler, D. A., 2015, In : Journal of Chemical Information and Modeling. 55, 8, p. 1529-1534 6 p.

Research output: Contribution to journalArticleResearchpeer-review

8 Citations (Scopus)

Robust prediction of personalized cell recognition from a cancer population by a dual targeting nanoparticle library

Le, T. C., Yan, B. & Winkler, D. A., 2015, In : Advanced Functional Materials. 25, 44, p. 6927-6935 9 p.

Research output: Contribution to journalArticleResearchpeer-review

23 Citations (Scopus)

Screening the medicines for malaria venture "malaria box" against the plasmodium falciparum aminopeptidases, M1, M17 and M18

Paiardini, A., Bamert, R. S., Kannan Sivaraman, K., Drinkwater, N., Mistry, S. N., Scammells, P. J. & McGowan, S., 2015, In : PLoS ONE. 10, 2, 14 p., e0115859.

Research output: Contribution to journalArticleResearchpeer-review

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2 Citations (Scopus)

Sent packing: protein engineering generates a new crystal form of Pseudomonas aeruginosa DsbA1 with increased catalytic surface accessibility

McMahon, R. M., Coincon, M., Tay, S., Heras, B., Morton, C. J., Scanlon, M. J. & Martin, J. L., 2015, In : Acta Crystallographica Section D: Biological Crystallography. 71, 12, p. 2386-2395 10 p.

Research output: Contribution to journalArticleResearchpeer-review

22 Citations (Scopus)

Significant accumulation of polymyxin in single renal tubular cells: a medicinal chemistry and triple correlative microscopy approach

Azad, M. A. K., Roberts, K. D., Yu, H., Liu, B., Schofield, A. V., James, S. A., Howard, D. L., Nation, R. L., Rogers, K. L., de Jonge, M. D., Thompson, P., Fu, J., Velkov, T. & Li, J., 2015, In : Analytical Chemistry. 87, 3, p. 1590 - 1595 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
5 Citations (Scopus)

Significant improvement of optoelectronic and photovoltaic properties by incorporating thiophene in a solution-processable D-A-D modular chromophore

Raynor, A. M., Gupta, A., Plummer, C. M., Jackson, S. L., Bilic, A., Patil, H., Sonar, P. & Bhosale, S. V., 2015, In : Molecules. 20, 12, p. 21787-21801 15 p.

Research output: Contribution to journalArticleResearchpeer-review

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10 Citations (Scopus)

Small molecule inhibitors of disulfide bond formation by the bacterial DsbA-DsbB dual enzyme system

Halili, M. A., Bachu, P., Lindahl, F., Bechara, C., Mohanty, B., Reid, R. C., Scanlon, M., Robinson, C. V., Fairlie, D. P. & Martin, J. L., 2015, In : ACS Chemical Biology. 10, 4, p. 957 - 964 8 p.

Research output: Contribution to journalArticleResearchpeer-review

16 Citations (Scopus)

Small molecules containing rigidified thiophenes and a cyanopyridone acceptor unit for solution-processable bulk-heterojunction solar cells

Gupta, A., Ali, A., Gao, M., Singh, B., Bilic, A., Watkins, S. E., Bach, U. & Evans, R. A., 2015, In : Dyes and Pigments. 119, p. 122-132 11 p.

Research output: Contribution to journalArticleResearchpeer-review

1 Citation (Scopus)

Solution structure and DNA binding of the catalytic domain of the large serine resolvase TnpX

Headey, S. J., Sivakumaran, A., Adams, V., Lyras, D., Rood, J. I., Scanlon, M. & Wilce, M. C. J., 2015, In : Journal of Molecular Recognition. 28, 5, p. 316-324 9 p.

Research output: Contribution to journalArticleResearchpeer-review

9 Citations (Scopus)

Sparse feature selection identifies H2A.Z as a novel, pattern-specific biomarker for asymmetrically self-renewing distributed stem cells

Huh, Y. H., Noh, M., Burden, F. R., Chen, J. C., Winkler, D. A. & Sherley, J. L., 2015, In : Stem Cell Research. 14, 2, p. 144-154 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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40 Citations (Scopus)

Sparse feature selection methods identify unexpected global cellular response to strontium-containing materials

Autefage, H., Gentleman, E., Littmann, E., Hedegaard, M. A. B., von Erlach, T., O'Donnell, M. D., Burden, F. R., Winkler, D. A. & Stevens, M. M., 2015, In : Proceedings of the National Academy of Sciences. 112, 14, p. 4280-4285 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
62 Citations (Scopus)

Specialized insulin is used for chemical warfare by fish-hunting cone snails

Safavi-Hemami, H., Gajewiak, J., Karanth, S., Robinson, S., Ueberheide, B., Douglass, A. D., Schlegel, A., Imperial, J. S., Watkins, M., Bandyopadhyay, P. K., Yandell, M., Li, Q., Purcell, A. W., Norton, R. S., Ellgaard, L. & Olivera, B. M., 2015, In : Proceedings of the National Academy of Sciences. 112, 6, p. 1743 - 1748 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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8 Citations (Scopus)

Structural basis for Ca2+-mediated interaction of the perforin C2 domain with lipid membranes

Yagi, H., Conroy, P. J., Leung, E. W. W., Law, R. H. P., Trapani, J. A., Voskoboinik, I., Whisstock, J. & Norton, R. S., 2015, In : Journal of Biological Chemistry. 290, 42, p. 25213-25226 14 p.

Research output: Contribution to journalArticleResearchpeer-review

13 Citations (Scopus)

Structural basis for epitope masking and strain specificity of a conserved epitope in an intrinsically disordered malaria vaccine candidate

De Almeida Vilela Morales, R., MacRaild, C. A., Seow, J. T-J., Krishnarjuna, B., Drinkwater, N., Rouet, R., Anders, R. F., Christ, D., McGowan, S. & Norton, R. S., 2015, In : Scientific Reports. 5, 10 p., 10103 .

Research output: Contribution to journalArticleResearchpeer-review

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21 Citations (Scopus)

Structural biology of antibody recognition of carbohydrate epitopes and potential uses for targeted cancer immunotherapies

Dingjan, T., Spendlove, I., Durrant, L. G., Scott, A. M., Yuriev, E. & Ramsland, P. A., 2015, In : Molecular Immunology. 67, 2, p. 75-88 14 p.

Research output: Contribution to journalArticleResearchpeer-review

4 Citations (Scopus)

Structural dynamics of the potassium channel blocker ShK: SRLS analysis of 15N relaxation

Meirovitch, E., Tchaicheeyan, O., Sher, I., Norton, R. S. & Chill, J. H., 2015, In : Journal of Physical Chemistry B. 119, 49, p. 15130-15137 8 p.

Research output: Contribution to journalArticleResearchpeer-review

15 Citations (Scopus)

Structure-activity relationship of flavonoids as potent inhibitors of carbonyl reductase 1 (CBR1)

Arai, Y., Endo, S., Miyagi, N., Abe, N., Miura, T., Nishinaka, T., Terada, T., Oyama, M., Goda, H., El-Kabbani, O., Hara, A., Matsunaga, T. & Ikari, A., 2015, In : Fitoterapia. 101, p. 51-56 6 p.

Research output: Contribution to journalArticleResearchpeer-review

21 Citations (Scopus)
6 Citations (Scopus)

Structure and functional characterization of the conserved JAK interaction region in the intrinsically disordered N-terminus of SOCS5

Chandrashekaran, I. R., Mohanty, B., Linossi, E. M., Dagley, L. F., Leung, E. W. W., Murphy, J. M., Babon, J. J., Nicholson, S. E. & Norton, R. S., 2015, In : Biochemistry. 54, 30, p. 4672-4682 11 p.

Research output: Contribution to journalArticleResearchpeer-review

4 Citations (Scopus)

Structure of amylase-binding protein A of Streptococcus gordonii: a potential receptor for human salivary α-amylase enzyme

Sethi, A., Mohanty, B., Ramasubbu, N. & Gooley, P. R., 2015, In : Protein Science. 24, 6, p. 1013-1018 6 p.

Research output: Contribution to journalArticleResearchpeer-review

5 Citations (Scopus)

Studies towards a concise enantioselective synthesis of roseophilins

Kerr, D. J. & Flynn, B. L., 2015, In : Australian Journal of Chemistry. 68, 12, p. 1821-1828 8 p.

Research output: Contribution to journalArticleResearchpeer-review

12 Citations (Scopus)

Surface-water interface induces conformational changes critical for protein adsorption: Implications for monolayer formation of EAS hydrophobin

Ley, K., Christofferson, A., Penna, M., Winkler, D., MacLaughlin, S. & Yarovsky, I., 16 Nov 2015, In : Frontiers in Molecular Biosciences. 2, NOV, 12 p., 64.

Research output: Contribution to journalArticleResearchpeer-review

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7 Citations (Scopus)

Synthesis, biological evaluation, and utility of fluorescent ligands targeting the μ-opioid receptor

Schembri, L. S., Stoddart, L. A., Briddon, S. J., Kellam, B., Canals, M., Graham, B. & Scammells, P. J., 2015, In : Journal of Medicinal Chemistry. 58, 24, p. 9754-9767 14 p.

Research output: Contribution to journalArticleResearchpeer-review

22 Citations (Scopus)

Synthesis and biodistribution studies of 3H- and 64Cu-labeled dendritic polyglycerol and dendritic polyglycerol sulfate

Pant, K., Groger, D., Bergmann, R., Pietzsch, J., Steinbach, J., Graham, B., Spiccia, L., Berthon, F., Czarny, B., Devel, L., Dive, V., Stephan, H. & Haag, R., 2015, In : Bioconjugate Chemistry. 26, 5, p. 906-918 13 p.

Research output: Contribution to journalArticleResearchpeer-review

5 Citations (Scopus)

Synthesis and evaluation of phenoxymethylbenzamide analogues as anti-trypanosomal agents

Manos-Turvey, A., Watson, E. E., Sykes, M. L., Jones, A. J., Baell, J. B., Kaiser, M., Avery, V. M. & Payne, R. J., 2015, In : MedChemComm. 6, 3, p. 403 - 406 4 p.

Research output: Contribution to journalArticleOtherpeer-review

32 Citations (Scopus)

Synthesis and pharmacological evaluation of dual acting ligands targeting the adenosine A2A and dopamine D2 receptors for the potential treatment of Parkinson's disease

Jorg, M. T., May, L. T., Mak, F. S., Lee, K. C. K., Miller, N. D., Scammells, P. J. & Capuano, B., 2015, In : Journal of Medicinal Chemistry. 58, 2, p. 718 - 738 21 p.

Research output: Contribution to journalArticleResearchpeer-review

8 Citations (Scopus)

Synthesis and pharmacological evaluation of M4 muscarinic receptor positive allosteric modulators derived from VU10004

Huynh, T., Valant, C., Crosby, I. T., Sexton, P., Christopoulos, A. & Capuano, B., 2015, In : ACS Chemical Neuroscience. 6, 6, p. 838 - 844 7 p.

Research output: Contribution to journalArticleResearchpeer-review

64 Citations (Scopus)

Targeting virulence not viability in the search for future antibacterials

Heras, B., Scanlon, M. & Martin, J. L., 2015, In : British Journal of Clinical Pharmacology. 79, 2, p. 208 - 215 8 p.

Research output: Contribution to journalArticleResearchpeer-review

7 Citations (Scopus)

The carbohydrate-binding promiscuity of Euonymus europaeus lectin is predicted to involve a single binding site

Agostino, M. J., Velkov, T., Dingjan, T., Williams, S. J., Yuriev, E. & Ramsland, P. A., 2015, In : Glycobiology. 25, 1, p. 101 - 114 14 p.

Research output: Contribution to journalArticleResearchpeer-review

18 Citations (Scopus)

Thermostability and reversibility of silver nanoparticle-protein binding

Wang, B., Seabrook, S. A., Nedumpully-Govindan, P., Chen, P., Yin, H., Waddington, L. J., Epa, V. C., Winkler, D. A., Kirby, J. K., Ding, F. & Ke, P. C., 2015, In : Physical Chemistry Chemical Physics. 17, 3, p. 1728-1739 12 p.

Research output: Contribution to journalArticleResearchpeer-review

15 Citations (Scopus)

Towards computational design of zeolite catalysts for CO2 reduction

Thornton, A. W., Winkler, D. A., Liu, M. S., Haranczyk, M. & Kennedy, D., 2015, In : RSC Advances. 5, 55, p. 44361-44370 10 p.

Research output: Contribution to journalArticleResearchpeer-review

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58 Citations (Scopus)

Transformation of poorly water-soluble drugs into lipophilic ionic liquids enhances oral drug exposure from lipid based formulations

Sahbaz, Y., Williams, H. D., Nguyen, T-H., Saunders, J. A., Ford, L., Charman, S. A., Scammells, P. J. & Porter, C. J., 2015, In : Molecular Pharmaceutics. 12, 6, p. 1980 - 1991 12 p.

Research output: Contribution to journalArticleResearchpeer-review

10 Citations (Scopus)

Up-regulation of carbonyl reductase 1 renders development of doxorubicin resistance in human gastrointestinal cancers

Matsunaga, T., Kezuka, C., Morikawa, Y., Suzuki, A., Endo, S., Iguchi, K., Miura, T., Nishinaka, T., Terada, T., El-Kabbani, O., Hara, A. & Ikari, A., 2015, In : Biological & Pharmaceutical Bulletin. 38, 9, p. 1309-1319 11 p.

Research output: Contribution to journalArticleResearchpeer-review

14 Citations (Scopus)

Using active learning strategies to shift student attitudes and behaviours about learning and teaching in a research intensive educational context

White, P. J., Larson, I., Styles, K., Yuriev, E., Evans, D. R., Short, J. L., Rangachari, P. K., Malone, D. T., Davie, B., Naidu, S. & Eise, N., 2015, In : Pharmacy Education. 15, 1, p. 116-126 11 p.

Research output: Contribution to journalArticleResearchpeer-review

2014
23 Citations (Scopus)

19F NMR as a probe of ligand interactions with the iNOS binding site of SPRY domain-containing SOCS box protein 2

Leung, E. W. W., Yagi, H., Harjani, J. R., Mulcair, M., Scanlon, M., Baell, J. B. & Norton, R. S., 2014, In : Chemical Biology & Drug Design. 84, 5, p. 616 - 625 10 p.

Research output: Contribution to journalArticleResearchpeer-review

9 Citations (Scopus)

A critical evaluation of pyrrolo[2,3-d]pyrimidine-4-amines as Plasmodium falciparum apical membrane antigen 1 (AMA1) inhibitors

Devine, S., Lim, S. S., Chandrashekaran, I. R., MacRaild, C. A., Drew, D. R., Debono, C., Lam, R., Anders, R. F., Beeson, J. G., Scanlon, M., Scammells, P. J. & Norton, R. S., 2014, In : MedChemComm. 5, 10, p. 1500 - 1506 7 p.

Research output: Contribution to journalArticleResearchpeer-review

198 Citations (Scopus)

Activation of the pseudokinase MLKL unleashes the four-helix bundle domain to induce membrane localization and necroptotic cell death

Hildebrand, J. M., Tanzer, M. C., Lucet, I. S., Young, S. N., Spall, S. K., Sharma, P., Pierotti, C., Garnier, J-M., Dobson, R. C. J., Webb, A. I., Tripaydonis, A., Babon, J. J., Mulcair, M., Scanlon, M. J., Alexander, W. S., Wilks, A. F., Czabotar, P. E., Lessene, G., Murphy, J. M. & Silke, J., 2014, In : Proceedings of the National Academy of Sciences. 111, 42, p. 15072 - 15077 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
37 Citations (Scopus)

A diketopyrrolopyrrole and benzothiadiazole based small molecule electron acceptor: Design, synthesis, characterization and photovoltaic properties

Raynor, A., Gupta, A., Patil, H., Bilic, A. & Bhosale, S. V., 2014, In : RSC Advances. 4, 101, p. 57635 - 57638 4 p.

Research output: Contribution to journalArticleResearchpeer-review

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