Research Output 1977 2019

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2015

Structural dynamics of the potassium channel blocker ShK: SRLS analysis of 15N relaxation

Meirovitch, E., Tchaicheeyan, O., Sher, I., Norton, R. S. & Chill, J. H., 2015, In : Journal of Physical Chemistry B. 119, 49, p. 15130-15137 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Structure-activity relationship of flavonoids as potent inhibitors of carbonyl reductase 1 (CBR1)

Arai, Y., Endo, S., Miyagi, N., Abe, N., Miura, T., Nishinaka, T., Terada, T., Oyama, M., Goda, H., El-Kabbani, O., Hara, A., Matsunaga, T. & Ikari, A., 2015, In : Fitoterapia. 101, p. 51-56 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Structure and functional characterization of the conserved JAK interaction region in the intrinsically disordered N-terminus of SOCS5

Chandrashekaran, I. R., Mohanty, B., Linossi, E. M., Dagley, L. F., Leung, E. W. W., Murphy, J. M., Babon, J. J., Nicholson, S. E. & Norton, R. S., 2015, In : Biochemistry. 54, 30, p. 4672-4682 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Structure of amylase-binding protein A of Streptococcus gordonii: a potential receptor for human salivary α-amylase enzyme

Sethi, A., Mohanty, B., Ramasubbu, N. & Gooley, P. R., 2015, In : Protein Science. 24, 6, p. 1013-1018 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Studies towards a concise enantioselective synthesis of roseophilins

Kerr, D. J. & Flynn, B. L., 2015, In : Australian Journal of Chemistry. 68, 12, p. 1821-1828 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Surface-water interface induces conformational changes critical for protein adsorption: Implications for monolayer formation of EAS hydrophobin

Ley, K., Christofferson, A., Penna, M., Winkler, D., MacLaughlin, S. & Yarovsky, I., 16 Nov 2015, In : Frontiers in Molecular Biosciences. 2, NOV, 12 p., 64.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Synthesis, biological evaluation, and utility of fluorescent ligands targeting the μ-opioid receptor

Schembri, L. S., Stoddart, L. A., Briddon, S. J., Kellam, B., Canals, M., Graham, B. & Scammells, P. J., 2015, In : Journal of Medicinal Chemistry. 58, 24, p. 9754-9767 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Synthesis and biodistribution studies of 3H- and 64Cu-labeled dendritic polyglycerol and dendritic polyglycerol sulfate

Pant, K., Groger, D., Bergmann, R., Pietzsch, J., Steinbach, J., Graham, B., Spiccia, L., Berthon, F., Czarny, B., Devel, L., Dive, V., Stephan, H. & Haag, R., 2015, In : Bioconjugate Chemistry. 26, 5, p. 906-918 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Synthesis and evaluation of phenoxymethylbenzamide analogues as anti-trypanosomal agents

Manos-Turvey, A., Watson, E. E., Sykes, M. L., Jones, A. J., Baell, J. B., Kaiser, M., Avery, V. M. & Payne, R. J., 2015, In : MedChemComm. 6, 3, p. 403 - 406 4 p.

Research output: Contribution to journalArticleOtherpeer-review

Synthesis and pharmacological evaluation of dual acting ligands targeting the adenosine A2A and dopamine D2 receptors for the potential treatment of Parkinson's disease

Jorg, M. T., May, L. T., Mak, F. S., Lee, K. C. K., Miller, N. D., Scammells, P. J. & Capuano, B., 2015, In : Journal of Medicinal Chemistry. 58, 2, p. 718 - 738 21 p.

Research output: Contribution to journalArticleResearchpeer-review

Synthesis and pharmacological evaluation of M4 muscarinic receptor positive allosteric modulators derived from VU10004

Huynh, T., Valant, C., Crosby, I. T., Sexton, P., Christopoulos, A. & Capuano, B., 2015, In : ACS Chemical Neuroscience. 6, 6, p. 838 - 844 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Targeting virulence not viability in the search for future antibacterials

Heras, B., Scanlon, M. & Martin, J. L., 2015, In : British Journal of Clinical Pharmacology. 79, 2, p. 208 - 215 8 p.

Research output: Contribution to journalArticleResearchpeer-review

The carbohydrate-binding promiscuity of Euonymus europaeus lectin is predicted to involve a single binding site

Agostino, M. J., Velkov, T., Dingjan, T., Williams, S. J., Yuriev, E. & Ramsland, P. A., 2015, In : Glycobiology. 25, 1, p. 101 - 114 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Thermostability and reversibility of silver nanoparticle-protein binding

Wang, B., Seabrook, S. A., Nedumpully-Govindan, P., Chen, P., Yin, H., Waddington, L. J., Epa, V. C., Winkler, D. A., Kirby, J. K., Ding, F. & Ke, P. C., 2015, In : Physical Chemistry Chemical Physics. 17, 3, p. 1728-1739 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Towards computational design of zeolite catalysts for CO2 reduction

Thornton, A. W., Winkler, D. A., Liu, M. S., Haranczyk, M. & Kennedy, D., 2015, In : RSC Advances. 5, 55, p. 44361-44370 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Transformation of poorly water-soluble drugs into lipophilic ionic liquids enhances oral drug exposure from lipid based formulations

Sahbaz, Y., Williams, H. D., Nguyen, T-H., Saunders, J. A., Ford, L., Charman, S. A., Scammells, P. J. & Porter, C. J., 2015, In : Molecular Pharmaceutics. 12, 6, p. 1980 - 1991 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Up-regulation of carbonyl reductase 1 renders development of doxorubicin resistance in human gastrointestinal cancers

Matsunaga, T., Kezuka, C., Morikawa, Y., Suzuki, A., Endo, S., Iguchi, K., Miura, T., Nishinaka, T., Terada, T., El-Kabbani, O., Hara, A. & Ikari, A., 2015, In : Biological & Pharmaceutical Bulletin. 38, 9, p. 1309-1319 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Using active learning strategies to shift student attitudes and behaviours about learning and teaching in a research intensive educational context

White, P. J., Larson, I., Styles, K., Yuriev, E., Evans, D. R., Short, J. L., Rangachari, P. K., Malone, D. T., Davie, B., Naidu, S. & Eise, N., 2015, In : Pharmacy Education. 15, 1, p. 116-126 11 p.

Research output: Contribution to journalArticleResearchpeer-review

2014

19F NMR as a probe of ligand interactions with the iNOS binding site of SPRY domain-containing SOCS box protein 2

Leung, E. W. W., Yagi, H., Harjani, J. R., Mulcair, M., Scanlon, M., Baell, J. B. & Norton, R. S., 2014, In : Chemical Biology & Drug Design. 84, 5, p. 616 - 625 10 p.

Research output: Contribution to journalArticleResearchpeer-review

A critical evaluation of pyrrolo[2,3-d]pyrimidine-4-amines as Plasmodium falciparum apical membrane antigen 1 (AMA1) inhibitors

Devine, S., Lim, S. S., Chandrashekaran, I. R., MacRaild, C. A., Drew, D. R., Debono, C., Lam, R., Anders, R. F., Beeson, J. G., Scanlon, M., Scammells, P. J. & Norton, R. S., 2014, In : MedChemComm. 5, 10, p. 1500 - 1506 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Activation of the pseudokinase MLKL unleashes the four-helix bundle domain to induce membrane localization and necroptotic cell death

Hildebrand, J. M., Tanzer, M. C., Lucet, I. S., Young, S. N., Spall, S. K., Sharma, P., Pierotti, C., Garnier, J-M., Dobson, R. C. J., Webb, A. I., Tripaydonis, A., Babon, J. J., Mulcair, M., Scanlon, M. J., Alexander, W. S., Wilks, A. F., Czabotar, P. E., Lessene, G., Murphy, J. M. & Silke, J., 2014, In : Proceedings of the National Academy of Sciences. 111, 42, p. 15072 - 15077 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

A diketopyrrolopyrrole and benzothiadiazole based small molecule electron acceptor: Design, synthesis, characterization and photovoltaic properties

Raynor, A., Gupta, A., Patil, H., Bilic, A. & Bhosale, S. V., 2014, In : RSC Advances. 4, 101, p. 57635 - 57638 4 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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A new mechanism of allostery in a G protein-coupled receptor dimer

Lane, J. R. D., Donthamsetti, P., Shonberg, J., Draper-Joyce, C. J., Dentry, S., Michino, M., Shi, L., Lopez Munoz, L., Scammells, P. J., Capuano, B., Sexton, P., Javitch, J. A. & Christopoulos, A., 2014, In : Nature Chemical Biology. 10, 9, p. 745 - 752 8 p.

Research output: Contribution to journalArticleResearchpeer-review

A new methodology for the synthesis of 3-amino-1H-indole-2-carboxylates

Harjani, J. R., Tang, A. X., Norton, R. S. & Baell, J. B., 2014, In : Tetrahedron. 70, 43, p. 8047 - 8055 9 p.

Research output: Contribution to journalArticleResearchpeer-review

A non-fullerene electron acceptor based on fluorene and diketopyrrolopyrrole building blocks for solution-processable organic solar cells with an impressive open-circuit voltage

Patil, H., Wang, X., Gupta, A., Chellappan, V., Bilic, A., Sonar, P., Rananaware, A., Bhosale, S. V. & Bhosale, S. V., 2014, In : Physical Chemistry Chemical Physics. 16, 43, p. 23837 - 23842 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Antibody recognition of Shiga toxins (Stxs): Computational identification of the epitopes of Stx2 subunit A to the antibodies 11E10 and S2C4

Jiao, Y., Legge, F. S., Zeng, X., Treutlein, H. R. & Zeng, J., 2014, In : PLoS ONE. 9, 2, 12 p., e88191.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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A potent and Kv1.3-selective analogue of the scorpion toxin HsTX1 as a potential therapeutic for autoimmune diseases

Rashid, H., Huq, R., Tanner, M. R., Chhabra, S., Khoo, K. K., Estrada, R., Dhawan, V., Chauhan, S., Pennington, M. W., Beeton, C., Kuyucak, S. & Norton, R. S., 2014, In : Scientific Reports. 4, 4509, p. 1 - 9 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

A potent cyclic peptide targeting SPSB2 protein as a potential anti-infective agent

Yap, B. K., Leung, E. W. W., Yagi, H., Galea, C., Chhabra, S., Chalmers, D. K., Nicholson, S. E., Thompson, P. & Norton, R. S., 2014, In : Journal of Medicinal Chemistry. 57, 16, p. 7006 - 7015 10 p.

Research output: Contribution to journalArticleResearchpeer-review

A secondary mode of action of polymyxins against Gram-negative bacteria involves the inhibition of NADH-quinone oxidoreductase activity

Deris, Z. Z., Akter, J., Sivanesan, S., Roberts, K. D., Thompson, P., Nation, R. L., Li, J. & Velkov, T., 2014, In : Journal of Antibiotics. 67, 2, p. 147 - 151 5 p.

Research output: Contribution to journalArticleResearchpeer-review

Assignments of human integrin a1I domain in the apo and Mg2+ bound states

Chin, Y. K-Y., Headey, S. J., Mohanty, B., Emsley, J., Simpson, J. S. & Scanlon, M., 2014, In : Biomolecular NMR Assignments. 8, 1, p. 117 - 121 5 p.

Research output: Contribution to journalArticleResearchpeer-review

A thrombopoietin antagonist is capable of affecting stem and progenitor cells of patients with myelofibrosis

Wang, X., Haylock, D., Hu, C. S., Mosoyan, G., Winkler, D. A. & Hoffman, R., 2014, In : Blood. 124, 21, p. 819 1 p.

Research output: Contribution to journalArticleOther

ATP sensitive bi-quinoline activator of the AMP-activated protein kinase

Scott, J. W., Oakhill, J. S., Ling, N. X. Y., Langendorf, C. G., Foitzik, R., Kemp, B. E. & Issinger, O-G., 2014, In : Biochemical and Biophysical Research Communications. 443, 2, p. 435 - 440 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Bacterial fatty acid synthesis: Effect of Tween 80 on antibiotic potency against Streptococcus agalactiae and methicillin-resistant Staphylococcus aureus

Krsta, D., Ku, K. U. C., Crosby, I. T., Capuano, B. & Manallack, D. T., 2014, In : Anti-Infective Agents. 12, 1, p. 80 - 84 5 p.

Research output: Contribution to journalArticleResearchpeer-review

Beyond loss of frataxin: The complex molecular pathology of friedreich ataxia

Evans-Galea, M. V., Lockhart, P. J., Galea, C., Hannan, A. J. & Delatycki, M., 2014, In : Discovery Medicine. 17, 91, p. 25 - 35 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Biased agonism at G protein-coupled receptors: The promise and the challenges - A medicinal chemistry perspective

Shonberg, J., Lopez Munoz, L., Scammells, P. J., Christopoulos, A., Capuano, B. & Lane, J. R. D., 2014, In : Medicinal Research Reviews. 34, 6, p. 1286 - 1330 45 p.

Research output: Contribution to journalArticleResearchpeer-review

Binding mode of the activity-modulating C-terminal segment of NS2B to NS3 in the dengue virus NS2B-NS3 protease

de la Cruz, L., Chen, W-N., Graham, B. & Otting, G., 2014, In : FEBS Journal. 281, 6, p. 1517 - 1533 17 p.

Research output: Contribution to journalArticleResearchpeer-review

Biomolecule detection in porous silicon based microcavities via europium luminescence enhancement

Aisyiyah, J. S. N., Du, Z., Mcinnes, S. J. P., Ung, P., Graham, B., Plush, S. E. & Voelcker, N., 2014, In : Journal of Materials Chemistry B. 2, 44, p. 7694 - 7703 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Calcium is the switch in the moonlighting dual function of the ligand-activated receptor kinase phytosulfokine receptor 1

Muleya, V., Wheeler, J., Ruzvidzo, O., Freihat, L., Manallack, D. T., Gehring, C. A. & Irving, H. R., 2014, In : Cell Communication and Signaling. 12, p. 1 - 5 5 p., 60.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Characterization of two distinct modes of drug binding to human intestinal fatty acid binding protein

Patil, R., Laguerre, A. K., Wielens, J., Headey, S. J., Williams, M., Hughes, M. L. R., Mohanty, B., Porter, C. J. & Scanlon, M., 2014, In : ACS Chemical Biology. 9, 11, p. 2526 - 2534 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Cloning and characterization of four rabbit aldo-keto reductases featuring broad substrate specificity for xenobiotic and endogenous carbonyl compounds: Relationship with multiple forms of drug ketone reductases

Endo, S., Matsunaga, T., Arai, Y., Ikari, A., Tajima, K., El-Kabbani, O., Yamano, S., Hara, A. & Kitade, Y., 2014, In : Drug Metabolism and Disposition. 42, 4, p. 803 - 812 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Comparison of moonlighting guanylate cyclases: Roles in signal direction?

Freihat, L., Muleya, V., Manallack, D. T., Wheeler, J. & Irving, H. R., 2014, In : Biochemical Society Transactions. 42, p. 1773 - 1779 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Computational approaches for designing potent and selective analogs of peptide toxins as novel therapeutics

Kuyucak, S. & Norton, R. S., 2014, In : Future Medicinal Chemistry. 6, 15, p. 1645 - 1658 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Conformational flexibility in the binding surface of the potassium channel blocker ShK

Sher, I., Chang, S. J., Li, Y., Chhabra, S., Palmer III, A. G., Norton, R. S. & Chill, J., 2014, In : ChemBioChem. 15, 16, p. 2402 - 2410 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Conotoxin gene superfamilies

Robinson, S. & Norton, R. S., 2014, In : Marine Drugs. 12, 12, p. 6058 - 6101 44 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Contrasting effects of nanoparticle binding on protein denaturation

Chen, P., Seabrook, S. A., Epa, V. C., Kurabayashi, K., Barnard, A. S., Winkler, D. A., Kirby, J. K. & Ke, P. C., 2014, In : Journal of Physical Chemistry C. 118, 38, p. 22069 - 22078 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Convergent access to polycyclic cyclopentanoids from a,b-unsaturated acid chlorides and alkynes through a reductive coupling, Nazarov cyclization sequence

Chaplin, J. H., Jackson, K. E., White, J. & Flynn, B. L., 2014, In : Journal of Organic Chemistry. 79, 8, p. 3659 - 3664 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Design, synthesis and evaluation of N6-substituted 2-aminoadenosine-5'-N-methylcarboxamides as A3 adenosine receptor agonists

Devine, S., May, L. T. & Scammells, P. J., 2014, In : MedChemComm. 5, 2, p. 192 - 196 5 p.

Research output: Contribution to journalArticleResearchpeer-review

Development of a photoactivatable allosteric ligand for the M1 muscarinic acetylcholine receptor

Davie, B. J., Sexton, P., Capuano, B., Christopoulos, A. & Scammells, P. J., 2014, In : ACS Chemical Neuroscience. 5, 10, p. 902 - 907 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Dicarba analogues of a-conotoxin RgIA. Structure, stability, and activity at potential pain targets

Chhabra, S., Belgi, A., Bartels, P., Van Lierop, B. J., Robinson, S., Kompella, S. N., Hung, A., Callaghan, B., Adams, D. J., Robinson, A. J. & Norton, R. S., 2014, In : Journal of Medicinal Chemistry. 57, 23, p. 9933 - 9944 12 p.

Research output: Contribution to journalArticleResearchpeer-review