Research Output 1977 2019

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2015
39 Citations (Scopus)

Biased allosteric modulation at the CaS receptor engendered by structurally diverse calcimimetics

Cook, A. E., Mistry, S. N., Gregory, K. J., Furness, S. G. B., Sexton, P., Scammells, P. J., Conigrave, A., Christopoulos, A. & Leach, K., 2015, In : British Journal of Pharmacology. 172, 1, p. 185 - 200 16 p.

Research output: Contribution to journalArticleResearchpeer-review

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2 Citations (Scopus)

Bonding in singlet and triplet butalene: insights from spin-coupled theory

Cooper, D. L., Karadakov, P. B. & Duke, B. J., 2015, In : The Journal of Physical Chemistry A. 119, 10, p. 2169-2175 7 p.

Research output: Contribution to journalArticleResearchpeer-review

19 Citations (Scopus)
15 Citations (Scopus)

Cellular uptake and localization of polymyxins in renal tubular cells using rationally designed fluorescent probes

Yun, B., Azad, M. A. K., Nowell, C. J., Nation, R. L., Thompson, P. E., Roberts, K. D., Velkov, T. & Li, J., 2015, In : Antimicrobial Agents and Chemotherapy. 59, 12, p. 7489-7496 8 p.

Research output: Contribution to journalArticleResearchpeer-review

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Chemistry Space-Time

Winkler, D. A., 2015, In : Perspectives in Science. 6, p. 2-14 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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19 Citations (Scopus)

Compact, hydrophilic, lanthanide-binding tags for paramagnetic NMR spectroscopy

Lee, M. D., Loh, C. T., Shin, J., Chhabra, S., Dennis, M. L., Otting, G., Swarbrick, J. D. & Graham, B., 2015, In : Chemical Science. 6, 4, p. 2614-2624 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
16 Citations (Scopus)

Conformational dynamics and antigenicity in the disordered malaria antigen merozoite surface protein 2

MacRaild, C. A., Zachrdla, M., Andrew, D. W., Krishnarjuna, B., Novacek, J., Zidek, L., Sklenar, V., Richards, J. S., Beeson, J. G., Anders, R. F. & Norton, R. S., 2015, In : PLoS ONE. 10, 3, 18 p., e0119899.

Research output: Contribution to journalArticleResearchpeer-review

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19 Citations (Scopus)

Conserved features in TamA enable interaction with TamB to drive the activity of the translocation and assembly module

Selkrig, J. P., Belousoff, M. J., Headey, S. J., Heinz, E., Shiota, T., Shen, H-H., Beckham, S. A., Bamert, R. S., Phan, M-D., Schembri, M. A., Wilce, M. C., Scanlon, M. J., Strugnell, R. A. & Lithgow, T. J., 2015, In : Scientific Reports. 5, 12 p., 12905.

Research output: Contribution to journalArticleResearchpeer-review

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9 Citations (Scopus)

Contrasting reactivity of CS2 with cyclic vs. acyclic amidines

Ang, M. T. C., Phan, L., Alshamrani, A. K., Harjani, J. R., Wang, R., Schatte, G., Mosey, N. J. & Jessop, P. G., 2015, In : European Journal of Organic Chemistry. 2015, 33, p. 7334-7343 10 p.

Research output: Contribution to journalArticleResearchpeer-review

4 Citations (Scopus)

Coordination chemistry of a mono-dibenzofuran derivative of 1,4,7,10-tetraazacyclododecane

Barreto Solano, J. A., Joshi, T., Venkatachalam, T., Reutens, D. C., Graham, B. & Spiccia, L., 2015, In : Journal of Coordination Chemistry. 68, 2, p. 335-349 15 p.

Research output: Contribution to journalArticleResearchpeer-review

9 Citations (Scopus)

Coumarin-based fluorescent sensors for zinc(II) and hypochlorite

Aulsebrook, M., Graham, B., Grace, M. R. & Tuck, K. L., 2015, In : Supramolecular Chemistry. 27, 11-12, p. 798-806 9 p.

Research output: Contribution to journalArticleResearchpeer-review

31 Citations (Scopus)

Defining the mechanisms by which the reactive oxygen species by-product, 4-hydroxynonenal, affects human sperm cell function

Baker, M. A., Weinberg, A. S., Hetherington, L., Villaverde, A-I., Velkov, T., Baell, J. B. & Gordon, C. P., 2015, In : Biology of Reproduction. 92, 4, p. 1 - 10 10 p.

Research output: Contribution to journalArticleResearchpeer-review

2 Citations (Scopus)

Demonstration of elevated levels of active cathepsin S in dextran sulfate sodium colitis using a new activatable probe

Barlow, N., Nasser, Y., Zhao, P., Sharma, N., Guerrero-Alba, R., Edgington-Mitchell, L. E., Lieu, T., Veldhuis, N. A., Poole, D. P., Conner, J. W., Lindstrom, E., Craig, A. W., Graham, B., Vanner, S. J. & Bunnett, N. W., 2015, In : Neurogastroenterology and Motility. 27, 11, p. 1675-1680 6 p.

Research output: Contribution to journalArticleResearchpeer-review

6 Citations (Scopus)

Design, synthesis, and biological evaluation of tetra-substituted thiophenes as inhibitors of p38alpha MAPK

Vinh, N., Devine, S., Munoz, L., Ryan, R. M., Wang, B. H., Krum, H., Chalmers, D. K., Simpson, J. S. & Scammells, P. J., 2015, In : ChemistryOpen. 4, 1, p. 56 - 64 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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1 Citation (Scopus)

Determinants of proteolysis and cell-binding for the shigella flexneri cytotoxin, SigA

Chua, E. G., Al-Hasani, K., Scanlon, M. J., Adler, B. & Sakellaris, H. H., 2015, In : Current Microbiology. 71, 5, p. 613 - 617 5 p.

Research output: Contribution to journalArticleResearchpeer-review

26 Citations (Scopus)

Development of highly selective Kv1.3-blocking peptides based on the sea anemone peptide ShK

Pennington, M. W., Chang, S. J., Chauhan, S., Huq, R., Tajhya, R. B., Chhabra, S., Norton, R. S. & Beeton, C., 2015, In : Marine Drugs. 13, 1, p. 529 - 542 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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26 Citations (Scopus)

Discovery by proteogenomics and characterization of an RF-amide neuropeptide from cone snail venom

Robinson, S., Safavi-Hemami, H., Raghuraman, S. C., Imperial, J. S., Papenfuss, A. T., Teichert, R. W., Purcell, A. W., Olivera, B. M. & Norton, R. S., 2015, In : Journal of Proteomics. 114, p. 38 - 47 10 p.

Research output: Contribution to journalArticleResearchpeer-review

31 Citations (Scopus)

Discovery of a novel class of negative allosteric modulator of the dopamine D2 receptor through fragmentation of a bitopic ligand

Mistry, S. N., Shonberg, J., Draper-Joyce, C. J., Klein Herenbrink, C., Michino, M., Shi, L., Christopoulos, A., Capuano, B., Scammells, P. J. & Lane, J. R. D., 2015, In : Journal of Medicinal Chemistry. 58, 17, p. 6819-6843 25 p.

Research output: Contribution to journalArticleResearchpeer-review

41 Citations (Scopus)

Discovery of a novel polymer for human pluripotent stem cell expansion and multilineage differentiation

Celiz, A., Smith, J. G. W., Patel, A. K., Hook, A. L., Rajamohan, D., George, V. T., Flatt, L., Patel, M. J., Epa, V. C., Singh, T., Langer, R. S. M., Anderson, D. G., Allen, N. D., Hay, D. C., Winkler, D. A., Barrett, D. A., Davies, M. C., Young, L., Denning, C. & Alexander, M. R., 2015, In : Advanced Materials. 27, 27, p. 4006-4012 7 p.

Research output: Contribution to journalArticleResearchpeer-review

69 Citations (Scopus)

Dynamic binding mode of a Synaptotagmin-1-SNARE complex in solution

Brewer, K. D., Bacaj, T., Cavalli, A., Camilloni, C., Swarbrick, J. D., Liu, J., Zhou, A., Zhou, P., Barlow, N., Xu, J., Seven, A. B., Prinslow, E. A., Voleti, R., Haussinger, D., Bonvin, A. M. J. J., Tomchick, D. R., Vendruscolo, M., Graham, B., Sudhof, T. C. & Rizo, J., 2015, In : Nature Structural and Molecular Biology. 22, 7, p. 555 - 564 10 p.

Research output: Contribution to journalArticleResearchpeer-review

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43 Citations (Scopus)

Enhancing the buccal mucosal delivery of peptide and protein therapeutics

Caon, T., Jin, L., Simoes, M. O. C., Norton, R. S. & Nicolazzo, J., 2015, In : Pharmaceutical Research. 32, 1, p. 1 - 21 21 p.

Research output: Contribution to journalArticleResearchpeer-review

2 Citations (Scopus)

Evidence for the in vitro bioactivation of aminopyrazole derivatives: trapping reactive aminopyrazole intermediates using glutathione ethyl ester in human liver microsomes

Ryan, E., Morrow, B. J., Hemley, C. F., Pinson, J-A., Charman, S. A., Chiu, F. C. K. & Foitzik, R. C., 2015, In : Chemical Research in Toxicology. 28, 9, p. 1747-1752 6 p.

Research output: Contribution to journalArticleResearchpeer-review

4 Citations (Scopus)

Examining the gastrointestinal transit of lipid-based liquid crystalline systems using whole-animal imaging

Pham, A. C., Nguyen, T-H., Nowell, C. J., Graham, B. & Boyd, B. J., 2015, In : Drug Delivery and Translational Research. 5, 6, p. 566-574 9 p.

Research output: Contribution to journalArticleResearchpeer-review

154 Citations (Scopus)

FAF-Drugs3: a web server for compound property calculation and chemical library design

Lagorce, D., Sperandio, O., Baell, J. B., Miteva, M. A. & Villoutreix, B. O., 1 Jul 2015, In : Nucleic Acids Research. 43, W1, p. W200-W207 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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37 Citations (Scopus)

Fatty acid-binding protein 5 facilitates the blood-brain barrier transport of docosahexaenoic acid

Pan, Y., Scanlon, M., Owada, Y., Yamamoto, Y., Porter, C. J. & Nicolazzo, J., 2015, In : Molecular Pharmaceutics. 12, 12, p. 4375 - 4385 11 p.

Research output: Contribution to journalArticleResearchpeer-review

20 Citations (Scopus)

Fatty acid-binding proteins 1 and 2 differentially modulate the activation of peroxisome proliferator-activated receptor alpha in a ligand-selective manner

Hughes, M. L. R., Liu, B., Halls, M. L., Wagstaff, K. M., Patil, R., Velkov, T., Jans, D. A., Bunnett, N. W., Scanlon, M. & Porter, C. J., 2015, In : Journal of Biological Chemistry. 290, 22, p. 13895 - 13906 12 p.

Research output: Contribution to journalArticleResearchpeer-review

5 Citations (Scopus)

Fatty acid binding proteins expressed at the human blood-brain barrier bind drugs in an isoform-specific manner

Lee, G. S. Y., Kappler, K., Porter, C. J., Scanlon, M. & Nicolazzo, J., 2015, In : Pharmaceutical Research. 32, 10, p. 3432 - 3446 15 p.

Research output: Contribution to journalArticleResearchpeer-review

18 Citations (Scopus)

Generation of pseudocontact shifts in proteins with lanthanides using small "clickable" nitrilotriacetic acid and iminodiacetic acid tags

Loh, C-T., Graham, B., Abdelkader, E. H., Tuck, K. L. & Otting, G., 2015, In : Chemistry - A European Journal. 21, 13, p. 5084-5092 9 p.

Research output: Contribution to journalArticleResearchpeer-review

1 Citation (Scopus)

Identification of a determinant for strict NADP(H)-specificity and high sensitivity to mixed-type steroid inhibitor of rabbit aldo-keto reductase 1C33 by site-directed mutagenesis

Endo, S., Matsunaga, T., Ikari, A., El-Kabbani, O., Hara, A. & Kitade, Y., 2015, In : Archives of Biochemistry and Biophysics. 569, p. 19-25 7 p.

Research output: Contribution to journalArticleResearchpeer-review

14 Citations (Scopus)

Identification of mechanistically distinct inhibitors of HIV-1 reverse transcriptase through fragment screening

La, J., Latham, C. F. M., Tinetti, R. N., Johnson, A. P., Tyssen, D. P., Huber, K. D., Sluis-Cremer, N., Simpson, J. S., Headey, S. J., Chalmers, D. K. & Tachedjian, G., 2015, In : Proceedings of the National Academy of Sciences. 112, 22, p. 6979-6984 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
33 Citations (Scopus)

Identification of potent phosphodiesterase inhibitors that demonstrate cyclic nucleotide-dependent functions in apicomplexan parasites

Howard, B. L., Harvey, K. L., Stewart, R. J., Azevedo, M. F., Crabb, B. S., Jennings, I., Sanders, P. R., Manallack, D. T., Thompson, P., Tonkin, C. J. & Gilson, P. R., 2015, In : ACS Chemical Biology. 10, 4, p. 1145 - 1154 10 p.

Research output: Contribution to journalArticleResearchpeer-review

3 Citations (Scopus)

Illuminating flash point: comprehensive prediction models

Le, T. C., Ballard, M. J., Casey, P., Liu, M. S. & Winkler, D. A., 2015, In : Molecular Informatics. 34, 1, p. 18-27 10 p.

Research output: Contribution to journalArticleResearchpeer-review

26 Citations (Scopus)

Imaging the distribution of polymyxins in the kidney

Yun, B., Azad, M. A. K., Wang, J., Nation, R. L., Thompson, P., Roberts, K. D., Velkov, T. & Li, J., 2015, In : Journal of Antimicrobial Chemotherapy. 70, 3, p. 827 - 829 3 p.

Research output: Contribution to journalArticleResearchpeer-review

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5 Citations (Scopus)

Immobilisation of a thrombopoietin peptidic mimic by self-assembled monolayers for culture of CD34+ cells

Lee, E-J., Be, C. L., Vinson, A. R., Riches, A. G., Fehr, F., Gardiner, J., Gengenbach, T. R., Winkler, D. A. & Haylock, D. N., 2015, In : Biomaterials. 37, p. 82-93 12 p.

Research output: Contribution to journalArticleResearchpeer-review

10 Citations (Scopus)

Improved synthesis of biotinol-5'-AMP: implications for antibacterial discovery

Tieu, W., Polyak, S. W., Paparella, A. S., Yap, M. Y., Soares da Costa, T. P., Ng, B., Wang, G., Lumb, R., Bell, J. M., Turnidge, J. D., Wilce, M. C., Booker, G. W. & Abell, A. D., 2015, In : ACS Medicinal Chemistry Letters. 6, 2, p. 216 - 220 5 p.

Research output: Contribution to journalArticleResearchpeer-review

11 Citations (Scopus)

Improvement of optoelectronic and photovoltaic properties through the insertion of a naphthalenediimide unit in donor-acceptor oligothiophenes

Bobe, S. R., Gupta, A., Rananaware, A., Bilic, A., Bhosale, S. V. & Bhosale, S. V., 2015, In : RSC Advances. 5, 6, p. 4411-4415 5 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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100 Citations (Scopus)

Improvements, trends, and new ideas in molecular docking: 2012-2013 in review

Yuriev, E., Holien, J. & Ramsland, P. A., 2015, In : Journal of Molecular Recognition. 28, 10, p. 581-604 24 p.

Research output: Contribution to journalArticleResearchpeer-review

28 Citations (Scopus)

Inhibition of AMP-activated protein kinase at the allosteric drug-binding site promotes islet insulin release

Scott, J. W., Galic, S., Graham, K. L., Foitzik, R., Ling, N. X. Y., Dite, T. A., Issa, S. M. A., Langendorf, C. G., Weng, Q. P., Thomas, H. E., Kay, T. W., Birnberg, N. C., Steinberg, G. R., Kemp, B. E. & Oakhill, J. S., 2015, In : Chemistry and Biology. 22, 6, p. 705-711 7 p.

Research output: Contribution to journalArticleResearchpeer-review

16 Citations (Scopus)

Insights into the immunological properties of intrinsically disordered malaria proteins using proteome scale predictions

Guy, A. J., Irani, V. R., MacRaild, C. A., Anders, R. F., Norton, R. S., Beeson, J. G., Richards, J. S. & Ramsland, P. A., 2015, In : PLoS ONE. 10, 10, 22 p., e0141729.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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18 Citations (Scopus)

Integral membrane protein structure determination using pseudocontact shifts

Crick, D. J., Wang, J. X., Graham, B., Swarbrick, J. D., Mott, H. R. & Nietlispach, D., 2015, In : Journal of Biomolecular NMR. 61, 3-4, p. 197-207 11 p.

Research output: Contribution to journalArticleResearchpeer-review

4 Citations (Scopus)

Isoindigo-based small molecules with varied donor components for solution-processable organic field effect transistor devices

Patil, H., Chang, J., Gupta, A., Bilic, A., Wu, J., Sonar, P. & Bhosale, S. V., 2015, In : Molecules. 20, 9, p. 17362-17377 16 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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7 Citations (Scopus)

Lanthanide complexes as luminogenic probes to measure sulfide levels in industrial samples

Thorson, M. K., Ung, P., Leaver, F. M., Corbin, T. S., Tuck, K. L., Graham, B. & Barrios, A. M., 2015, In : Analytica Chimica Acta. 896, p. 160-165 6 p.

Research output: Contribution to journalArticleResearchpeer-review

40 Citations (Scopus)

Low cost whole-organism screening of compounds for anthelmintic activity

Preston, S., Jabbar, A., Nowell, C. J., Joachim, A., Ruttkowski, B., Baell, J. B., Cardno, T., Korhonen, P. K., Piedrafita, D. M., Ansell, B. R. E., Jex, A. R., Hofmann, A. & Gasser, R. B., 2015, In : International Journal for Parasitology. 45, 5, p. 333 - 343 11 p.

Research output: Contribution to journalArticleResearchpeer-review

46 Citations (Scopus)

Macrocyclic metal complexes for metalloenzyme mimicry and sensor development

Joshi, T., Graham, B. & Spiccia, L., 2015, In : Accounts of Chemical Research. 48, 8, p. 2366-2379 14 p.

Research output: Contribution to journalArticleResearchpeer-review

11 Citations (Scopus)

Mapping the interactions of I2, I; I-, and I+ with alkynes and their roles in iodocyclizations

Volpe, R., Aurelio, L., Gillin, M., Krenske, E. H. & Flynn, B. L., 2015, In : Chemistry - A European Journal. 21, 28, p. 10191 - 10199 9 p.

Research output: Contribution to journalArticleResearchpeer-review

8 Citations (Scopus)

Mechanistic details of the membrane perforation and passive translocation of TAT peptides

Piantavigna, S., Abdelhamid, M., Zhao, C., Qu, X., McCubbin, G. A., Graham, B., Spiccia, L., O'Mullane, A. P. & Martin, L. L., 2015, In : ChemPlusChem. 80, 1, p. 83-90 8 p.

Research output: Contribution to journalArticleResearchpeer-review

4 Citations (Scopus)

Molecular characterisation of the haemagglutinin glycan-binding specificity of egg-adapted vaccine strains of the pandemic 2009 H1N1 swine influenza A virus

Carbone, V., Schneider, E. K., Rockman, S., Baker, M., Huang, J. X., Ong, C., Cooper, M. A., Yuriev, E., Li, J. & Velkov, T., 2015, In : Molecules. 20, 6, p. 10415-10434 20 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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13 Citations (Scopus)

New organic sensitizers using 4-(cyanomethyl)benzoic acid as an acceptor group for dye-sensitized solar cell applications

Gupta, A., Armel, V., Xiang, W., Bilic, A. & Evans, R. A., 2015, In : Dyes and Pigments. 113, p. 280-288 9 p.

Research output: Contribution to journalArticleResearchpeer-review

2 Citations (Scopus)

Nitrogen-containing ionic liquids: biodegradation studies and utility in base-mediated reactions

Ford, L., Ylijoki, K. E. O., Garcia, M. T., Singer, R. D. & Scammells, P. J., 2015, In : Australian Journal of Chemistry. 68, 6, p. 849 - 857 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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4 Citations (Scopus)

NMR structure determination of the protein NP_344798.1 as the first representative of Pfam PF06042

Mohanty, B., Serrano, P., Geralt, M. & Wuthrich, K., 2015, In : Journal of Biomolecular NMR. 61, 1, p. 83-87 5 p.

Research output: Contribution to journalArticleResearchpeer-review