Research Output 1977 2019

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2015

Examining the gastrointestinal transit of lipid-based liquid crystalline systems using whole-animal imaging

Pham, A. C., Nguyen, T-H., Nowell, C. J., Graham, B. & Boyd, B. J., 2015, In : Drug Delivery and Translational Research. 5, 6, p. 566-574 9 p.

Research output: Contribution to journalArticleResearchpeer-review

FAF-Drugs3: a web server for compound property calculation and chemical library design

Lagorce, D., Sperandio, O., Baell, J. B., Miteva, M. A. & Villoutreix, B. O., 1 Jul 2015, In : Nucleic Acids Research. 43, W1, p. W200-W207 8 p.

Research output: Contribution to journalArticleResearchpeer-review

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Fatty acid-binding protein 5 facilitates the blood-brain barrier transport of docosahexaenoic acid

Pan, Y., Scanlon, M., Owada, Y., Yamamoto, Y., Porter, C. J. & Nicolazzo, J., 2015, In : Molecular Pharmaceutics. 12, 12, p. 4375 - 4385 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Fatty acid-binding proteins 1 and 2 differentially modulate the activation of peroxisome proliferator-activated receptor alpha in a ligand-selective manner

Hughes, M. L. R., Liu, B., Halls, M. L., Wagstaff, K. M., Patil, R., Velkov, T., Jans, D. A., Bunnett, N. W., Scanlon, M. & Porter, C. J., 2015, In : Journal of Biological Chemistry. 290, 22, p. 13895 - 13906 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Fatty acid binding proteins expressed at the human blood-brain barrier bind drugs in an isoform-specific manner

Lee, G. S. Y., Kappler, K., Porter, C. J., Scanlon, M. & Nicolazzo, J., 2015, In : Pharmaceutical Research. 32, 10, p. 3432 - 3446 15 p.

Research output: Contribution to journalArticleResearchpeer-review

Generation of pseudocontact shifts in proteins with lanthanides using small "clickable" nitrilotriacetic acid and iminodiacetic acid tags

Loh, C-T., Graham, B., Abdelkader, E. H., Tuck, K. L. & Otting, G., 2015, In : Chemistry - A European Journal. 21, 13, p. 5084-5092 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Identification of a determinant for strict NADP(H)-specificity and high sensitivity to mixed-type steroid inhibitor of rabbit aldo-keto reductase 1C33 by site-directed mutagenesis

Endo, S., Matsunaga, T., Ikari, A., El-Kabbani, O., Hara, A. & Kitade, Y., 2015, In : Archives of Biochemistry and Biophysics. 569, p. 19-25 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Identification of mechanistically distinct inhibitors of HIV-1 reverse transcriptase through fragment screening

La, J., Latham, C. F. M., Tinetti, R. N., Johnson, A. P., Tyssen, D. P., Huber, K. D., Sluis-Cremer, N., Simpson, J. S., Headey, S. J., Chalmers, D. K. & Tachedjian, G., 2015, In : Proceedings of the National Academy of Sciences. 112, 22, p. 6979-6984 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Identification of potent phosphodiesterase inhibitors that demonstrate cyclic nucleotide-dependent functions in apicomplexan parasites

Howard, B. L., Harvey, K. L., Stewart, R. J., Azevedo, M. F., Crabb, B. S., Jennings, I., Sanders, P. R., Manallack, D. T., Thompson, P., Tonkin, C. J. & Gilson, P. R., 2015, In : ACS Chemical Biology. 10, 4, p. 1145 - 1154 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Illuminating flash point: comprehensive prediction models

Le, T. C., Ballard, M. J., Casey, P., Liu, M. S. & Winkler, D. A., 2015, In : Molecular Informatics. 34, 1, p. 18-27 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Imaging the distribution of polymyxins in the kidney

Yun, B., Azad, M. A. K., Wang, J., Nation, R. L., Thompson, P., Roberts, K. D., Velkov, T. & Li, J., 2015, In : Journal of Antimicrobial Chemotherapy. 70, 3, p. 827 - 829 3 p.

Research output: Contribution to journalArticleResearchpeer-review

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Immobilisation of a thrombopoietin peptidic mimic by self-assembled monolayers for culture of CD34+ cells

Lee, E-J., Be, C. L., Vinson, A. R., Riches, A. G., Fehr, F., Gardiner, J., Gengenbach, T. R., Winkler, D. A. & Haylock, D. N., 2015, In : Biomaterials. 37, p. 82-93 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Improved synthesis of biotinol-5'-AMP: implications for antibacterial discovery

Tieu, W., Polyak, S. W., Paparella, A. S., Yap, M. Y., Soares da Costa, T. P., Ng, B., Wang, G., Lumb, R., Bell, J. M., Turnidge, J. D., Wilce, M. C., Booker, G. W. & Abell, A. D., 2015, In : A C S Medicinal Chemistry Letters. 6, 2, p. 216 - 220 5 p.

Research output: Contribution to journalArticleResearchpeer-review

Improvement of optoelectronic and photovoltaic properties through the insertion of a naphthalenediimide unit in donor-acceptor oligothiophenes

Bobe, S. R., Gupta, A., Rananaware, A., Bilic, A., Bhosale, S. V. & Bhosale, S. V., 2015, In : RSC Advances. 5, 6, p. 4411-4415 5 p.

Research output: Contribution to journalArticleResearchpeer-review

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Improvements, trends, and new ideas in molecular docking: 2012-2013 in review

Yuriev, E., Holien, J. & Ramsland, P. A., 2015, In : Journal of Molecular Recognition. 28, 10, p. 581-604 24 p.

Research output: Contribution to journalArticleResearchpeer-review

Inhibition of AMP-activated protein kinase at the allosteric drug-binding site promotes islet insulin release

Scott, J. W., Galic, S., Graham, K. L., Foitzik, R., Ling, N. X. Y., Dite, T. A., Issa, S. M. A., Langendorf, C. G., Weng, Q. P., Thomas, H. E., Kay, T. W., Birnberg, N. C., Steinberg, G. R., Kemp, B. E. & Oakhill, J. S., 2015, In : Chemistry and Biology. 22, 6, p. 705-711 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Insights into the immunological properties of intrinsically disordered malaria proteins using proteome scale predictions

Guy, A. J., Irani, V. R., MacRaild, C. A., Anders, R. F., Norton, R. S., Beeson, J. G., Richards, J. S. & Ramsland, P. A., 2015, In : PLoS ONE. 10, 10, 22 p., e0141729.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Integral membrane protein structure determination using pseudocontact shifts

Crick, D. J., Wang, J. X., Graham, B., Swarbrick, J. D., Mott, H. R. & Nietlispach, D., 2015, In : Journal of Biomolecular NMR. 61, 3-4, p. 197-207 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Isoindigo-based small molecules with varied donor components for solution-processable organic field effect transistor devices

Patil, H., Chang, J., Gupta, A., Bilic, A., Wu, J., Sonar, P. & Bhosale, S. V., 2015, In : Molecules. 20, 9, p. 17362-17377 16 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Lanthanide complexes as luminogenic probes to measure sulfide levels in industrial samples

Thorson, M. K., Ung, P., Leaver, F. M., Corbin, T. S., Tuck, K. L., Graham, B. & Barrios, A. M., 2015, In : Analytica Chimica Acta. 896, p. 160-165 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Low cost whole-organism screening of compounds for anthelmintic activity

Preston, S., Jabbar, A., Nowell, C. J., Joachim, A., Ruttkowski, B., Baell, J. B., Cardno, T., Korhonen, P. K., Piedrafita, D. M., Ansell, B. R. E., Jex, A. R., Hofmann, A. & Gasser, R. B., 2015, In : International Journal for Parasitology. 45, 5, p. 333 - 343 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Macrocyclic metal complexes for metalloenzyme mimicry and sensor development

Joshi, T., Graham, B. & Spiccia, L., 2015, In : Accounts of Chemical Research. 48, 8, p. 2366-2379 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Mapping the interactions of I2, I; I-, and I+ with alkynes and their roles in iodocyclizations

Volpe, R., Aurelio, L., Gillin, M., Krenske, E. H. & Flynn, B. L., 2015, In : Chemistry - A European Journal. 21, 28, p. 10191 - 10199 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Mechanistic details of the membrane perforation and passive translocation of TAT peptides

Piantavigna, S., Abdelhamid, M., Zhao, C., Qu, X., McCubbin, G. A., Graham, B., Spiccia, L., O'Mullane, A. P. & Martin, L. L., 2015, In : ChemPlusChem. 80, 1, p. 83-90 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Molecular characterisation of the haemagglutinin glycan-binding specificity of egg-adapted vaccine strains of the pandemic 2009 H1N1 swine influenza A virus

Carbone, V., Schneider, E. K., Rockman, S., Baker, M., Huang, J. X., Ong, C., Cooper, M. A., Yuriev, E., Li, J. & Velkov, T., 2015, In : Molecules. 20, 6, p. 10415-10434 20 p.

Research output: Contribution to journalArticleResearchpeer-review

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New organic sensitizers using 4-(cyanomethyl)benzoic acid as an acceptor group for dye-sensitized solar cell applications

Gupta, A., Armel, V., Xiang, W., Bilic, A. & Evans, R. A., 2015, In : Dyes and Pigments. 113, p. 280-288 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Nitrogen-containing ionic liquids: biodegradation studies and utility in base-mediated reactions

Ford, L., Ylijoki, K. E. O., Garcia, M. T., Singer, R. D. & Scammells, P. J., 2015, In : Australian Journal of Chemistry. 68, 6, p. 849 - 857 9 p.

Research output: Contribution to journalArticleResearchpeer-review

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NMR structure determination of the protein NP_344798.1 as the first representative of Pfam PF06042

Mohanty, B., Serrano, P., Geralt, M. & Wuthrich, K., 2015, In : Journal of Biomolecular NMR. 61, 1, p. 83-87 5 p.

Research output: Contribution to journalArticleResearchpeer-review

N-terminally extended analogues of the K+ channel toxin from Stichodactyla helianthus as potent and selective blockers of the voltage-gated potassium channel Kv1.3

Chang, S. C., Huq, R., Chhabra, S., Beeton, C., Pennington, M. W., Smith, B. J. & Norton, R. S., 2015, In : FEBS Journal. 282, 12, p. 2247-2259 13 p.

Research output: Contribution to journalArticleResearchpeer-review

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O-tert-butyltyrosine, an NMR tag for high-molecular-weight systems and measurements of submicromolar ligand binding affinities

Chen, W-N., Kuppan, K. V., Lee, M. D., Jaudzems, K., Huber, T. & Otting, G., 2015, In : Journal of the American Chemical Society. 137, 13, p. 4581-4586 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Probing enzyme-nanoparticle interactions using combinatorial gold nanoparticle libraries

Liu, Y., Winkler, D. A., Epa, V. C., Zhang, B. & Yan, B., 2015, In : Nano Research. 8, 4, p. 1293-1308 16 p.

Research output: Contribution to journalArticleResearchpeer-review

Profiling the role of deacylation-reacylation in the lymphatic transport of a triglyceride-mimetic prodrug

Han, S., Hu, L., Quach, T., Simpson, J. S., Trevaskis, N. & Porter, C. J., 2015, In : Pharmaceutical Research. 32, 5, p. 1830-1844 15 p.

Research output: Contribution to journalArticleResearchpeer-review

Progress toward the development of noscapine and derivatives as anticancer agents

DeBono, A., Capuano, B. & Scammells, P. J., 2015, In : Journal of Medicinal Chemistry. 58, 15, p. 5699-5727 29 p.

Research output: Contribution to journalArticleResearchpeer-review

Promiscuous 2-aminothiazoles (PrATs): a frequent hitting scaffold

Devine, S., Mulcair, M., Debono, C., Leung, E. W. W., Nissink, J. W. M., Lim, S. S., Chandrashekaran, I. R., Vazirani, M., Mohanty, B., Simpson, J. S., Baell, J. B., Scammells, P. J., Norton, R. S. & Scanlon, M., 2015, In : Journal of Medicinal Chemistry. 58, 3, p. 1205 - 1214 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Proof of concept study for designed multiple ligands targeting the dopamine D2, serotonin 5-HT2A, and muscarinic M1 acetylcholine receptors

Szabo, M., Lim, H. D., Klein Herenbrink, C., Christopoulos, A., Lane, J. R. D. & Capuano, B., 2015, In : Journal of Medicinal Chemistry. 58, 3, p. 1550 - 1555 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Propargyloxyproline regio- and stereoisomers for click-conjugation of peptides: synthesis and application in linear and cyclic peptides

Northfield, S. E., Mountford, S. J., Wielens, J., Liu, M., Zhang, L., Herzog, H., Holliday, N. D., Scanlon, M., Parker, M. W., Chalmers, D. K. & Thompson, P., 2015, In : Australian Journal of Chemistry. 68, 9, p. 1365-1372 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Protective roles of aldo-keto reductase 1B10 and autophagy against toxicity induced by p-quinone metabolites of tert-butylhydroquinone in lung cancer A549 cells

Endo, S., Nishiyama, A., Suyama, M., Takemura, M., Soda, M., Chen, H., Tajima, K., El-Kabbani, O., Bunai, Y., Hara, A., Matsunaga, T. & Ikari, A., 2015, In : Chemico-Biological Interactions. 234, p. 282-289 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Protein conformation by EPR spectroscopy using gadolinium tags clicked to genetically encoded p-azido-L-phenylalanine

Abdelkader, E. H., Feintuch, A., Yao, X., Adams, L. A., Aurelio, L., Graham, B., Goldfarb, D. & Otting, G., 2015, In : Chemical Communications. 51, 88, p. 15898-15901 4 p.

Research output: Contribution to journalArticleResearchpeer-review

Real-time examination of aminoglycoside activity towards bacterial mimetic membranes using Quartz Crystal Microbalance with Dissipation monitoring (QCM-D)

Joshi, T., Voo, Z. X., Graham, B., Spiccia, L. & Martin, L. L., 2015, In : Biochimica et Biophysica Acta - Biomembranes. 1848, 2, p. 385 - 391 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Regio- and stereoselective iodoacyloxylations of alkynes

Priebbenow, D., Gable, R. W. & Baell, J. B., 2015, In : Journal of Organic Chemistry. 80, 9, p. 4412 - 4418 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Relevance vector machines: sparse classification methods for QSAR

Burden, F. R. & Winkler, D. A., 2015, In : Journal of Chemical Information and Modeling. 55, 8, p. 1529-1534 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Robust prediction of personalized cell recognition from a cancer population by a dual targeting nanoparticle library

Le, T. C., Yan, B. & Winkler, D. A., 2015, In : Advanced Functional Materials. 25, 44, p. 6927-6935 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Screening the medicines for malaria venture "malaria box" against the plasmodium falciparum aminopeptidases, M1, M17 and M18

Paiardini, A., Bamert, R. S., Kannan Sivaraman, K., Drinkwater, N., Mistry, S. N., Scammells, P. J. & McGowan, S., 2015, In : PLoS ONE. 10, 2, 14 p., e0115859.

Research output: Contribution to journalArticleResearchpeer-review

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Sent packing: protein engineering generates a new crystal form of Pseudomonas aeruginosa DsbA1 with increased catalytic surface accessibility

McMahon, R. M., Coincon, M., Tay, S., Heras, B., Morton, C. J., Scanlon, M. J. & Martin, J. L., 2015, In : Acta Crystallographica Section D: Biological Crystallography. 71, 12, p. 2386-2395 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Significant accumulation of polymyxin in single renal tubular cells: a medicinal chemistry and triple correlative microscopy approach

Azad, M. A. K., Roberts, K. D., Yu, H., Liu, B., Schofield, A. V., James, S. A., Howard, D. L., Nation, R. L., Rogers, K. L., de Jonge, M. D., Thompson, P., Fu, J., Velkov, T. & Li, J., 2015, In : Analytical Chemistry. 87, 3, p. 1590 - 1595 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Significant improvement of optoelectronic and photovoltaic properties by incorporating thiophene in a solution-processable D-A-D modular chromophore

Raynor, A. M., Gupta, A., Plummer, C. M., Jackson, S. L., Bilic, A., Patil, H., Sonar, P. & Bhosale, S. V., 2015, In : Molecules. 20, 12, p. 21787-21801 15 p.

Research output: Contribution to journalArticleResearchpeer-review

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Small molecule inhibitors of disulfide bond formation by the bacterial DsbA-DsbB dual enzyme system

Halili, M. A., Bachu, P., Lindahl, F., Bechara, C., Mohanty, B., Reid, R. C., Scanlon, M., Robinson, C. V., Fairlie, D. P. & Martin, J. L., 2015, In : ACS Chemical Biology. 10, 4, p. 957 - 964 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Small molecules containing rigidified thiophenes and a cyanopyridone acceptor unit for solution-processable bulk-heterojunction solar cells

Gupta, A., Ali, A., Gao, M., Singh, B., Bilic, A., Watkins, S. E., Bach, U. & Evans, R. A., 2015, In : Dyes and Pigments. 119, p. 122-132 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Solution structure and DNA binding of the catalytic domain of the large serine resolvase TnpX

Headey, S. J., Sivakumaran, A., Adams, V., Lyras, D., Rood, J. I., Scanlon, M. & Wilce, M. C. J., 2015, In : Journal of Molecular Recognition. 28, 5, p. 316-324 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Sparse feature selection identifies H2A.Z as a novel, pattern-specific biomarker for asymmetrically self-renewing distributed stem cells

Huh, Y. H., Noh, M., Burden, F. R., Chen, J. C., Winkler, D. A. & Sherley, J. L., 2015, In : Stem Cell Research. 14, 2, p. 144-154 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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