Research Output 1977 2019

Filter
Article
2016
8 Citations (Scopus)

A novel chemical biology approach for mapping of polymyxin lipopeptide antibody binding epitopes

Velkov, T., Yun, B., Schneider, E. K., Azad, M. A. K., Dolezal, O., Morris, F. C., Nation, R. L., Wang, J., Chen, K., Yu, H., Wang, L., Thompson, P. E., Roberts, K. D. & Li, J., 2016, In : ACS Infectious Diseases. 2, 5, p. 341-351 11 p.

Research output: Contribution to journalArticleResearchpeer-review

5 Citations (Scopus)

A novel compound which sensitizes BRAF wild-type melanoma cells to vemurafenib in a TRIM16-dependent manner

Sutton, S. K., Carter, D. R., Kim, P., Tan, O., Arndt, G. M., Zhang, X. D., Baell, J., Noll, B. D., Wang, S., Kumar, N., McArthur, G. A., Cheung, B. B. & Marshall, G. M., 1 Aug 2016, In : Oncotarget. 7, 32, p. 52166-52178 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
6 Citations (Scopus)

A novel serpin regulatory mechanism: SERPINB9 is reversibly inhibited by vicinal disulfide bond formation in the reactive center loop

Mangan, M. S. J., Bird, C. H., Kaiserman, D., Matthews, A. Y., Hitchen, C., Steer, D. L., Thompson, P. E. & Bird, P. I., 12 Feb 2016, In : Journal of Biological Chemistry. 291, 7, p. 3626-3638 13 p.

Research output: Contribution to journalArticleResearchpeer-review

6 Citations (Scopus)

Antagonism of the proinflammatory and pronociceptive actions of canonical and biased agonists of protease-activated receptor-2

Lieu, T., Savage, E., Zhao, P., Edgington-Mitchell, L., Barlow, N., Bron, R., Poole, D. P., McLean, P., Lohman, R. J., Fairlie, D. P. & Bunnett, N. W., 1 Sep 2016, In : British Journal of Pharmacology. 173, 18, p. 2752-2765 14 p.

Research output: Contribution to journalArticleResearchpeer-review

17 Citations (Scopus)

Antibody recognition of disordered antigens

Macraild, C. A., Richards, J. S., Anders, R. F. & Norton, R. S., 5 Jan 2016, In : Structure. 24, 1, p. 148-157 10 p.

Research output: Contribution to journalArticleResearchpeer-review

60 Citations (Scopus)

A renaissance of neural networks in drug discovery

Baskin, I. I., Winkler, D. & Tetko, I. V., 2016, In : Expert Opinion on Drug Delivery. 11, 8, p. 785-795 11 p.

Research output: Contribution to journalArticleResearchpeer-review

8 Citations (Scopus)

A thrombopoietin receptor antagonist is capable of depleting myelofibrosis hematopoietic stem and progenitor cells

Wang, X., Haylock, D., Hu, C. S., Kowalczyk, W., Jiang, T., Qiu, J., Mosoyan, G., He, W., Marshall, N., Mascarenhas, J., Tarasova, A., Brody, J., Winkler, D. & Hoffman, R., 30 Jun 2016, In : Blood. 127, 26, p. 3398-3409 12 p.

Research output: Contribution to journalArticleResearchpeer-review

6 Citations (Scopus)

Beta amino acid-modified and fluorescently labelled kisspeptin analogues with potent KISS1R activity

Camerino, M., Liu, M., Moriya, S., Kitahashi, T., Mahgoub, A., Mountford, S., Chalmers, D. K., Soga, T., Parhar, I. & Thompson, P., 1 Jun 2016, In : Journal of Peptide Science. 22, 6, p. 406-414 9 p.

Research output: Contribution to journalArticleResearchpeer-review

5 Citations (Scopus)

Binding of CFA/I pili of enterotoxigenic Escherichia coli to asialo-GM1 is mediated by the minor pilin CfaE

Madhavan, T. P. V., Riches, J. D., Scanlon, M. J., Ulett, G. C. & Sakellaris, H., 1 May 2016, In : Infection and Immunity. 84, 5, p. 1642-1649 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
61 Citations (Scopus)

Cell permeability beyond the rule of 5

Matsson, P., Doak, B. C., Over, B. & Kihlberg, J., 1 Jun 2016, In : Advanced Drug Delivery Reviews. 101, p. 42-61 20 p.

Research output: Contribution to journalArticleResearchpeer-review

8 Citations (Scopus)

Cellular uptake and photo-cytotoxicity of a gadolinium(III)-DOTA-naphthalimide complex "clicked" to a lipidated tat peptide

O'Malley, W., Rubbiani, R., Aulsebrook, M., Grace, M., Spiccia, L., Tuck, K., Gasser, G. & Graham, B., 1 Feb 2016, In : Molecules. 21, 2, p. 1-16 16 p., 194.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
13 Citations (Scopus)

Clickable Photoaffinity Ligands for Metabotropic Glutamate Receptor 5 Based on Select Acetylenic Negative Allosteric Modulators

Gregory, K., Velagaleti, R., Thal, D. M., Brady, R. M., Christopoulos, A., Conn, P. J. & Lapinsky, D. J., 15 Jul 2016, In : ACS Chemical Biology. 11, 7, p. 1870-1879 10 p.

Research output: Contribution to journalArticleResearchpeer-review

32 Citations (Scopus)

Compound heterozygous FXN mutations and clinical outcome in Friedreich ataxia

Galea, C., Huq, A., Lockhart, P. J., Tai, G., Corben, L., Yiu, E. M., Gurrin, L. C., Lynch, D. R., Gelbard, S., Durr, A., Pousset, F., Parkinson, M., Labrum, R., Giunti, P., Perlman, S. L., Delatycki, M. & Evans-Galea, M. V., 2016, In : Annals of Neurology. 79, 3, p. 485-495 11 p.

Research output: Contribution to journalArticleResearchpeer-review

10 Citations (Scopus)

Comprehensive vibrational spectroscopic investigation of trans,trans,trans-[Pt(N3)2(OH)2(py)2], a Pt(IV) diazido anticancer prodrug candidate

Vernooij, R. R., Joshi, T., Shaili, E., Kubeil, M., Appadoo, D. R. T., Izgorodina, E. I., Graham, B., Sadler, P. J., Wood, B. & Spiccia, L., 20 Jun 2016, In : Inorganic Chemistry. 55, 12, p. 5983-5992 10 p.

Research output: Contribution to journalArticleResearchpeer-review

4 Citations (Scopus)
5 Citations (Scopus)

Crossword puzzles for chemistry education: Learning goals beyond vocabulary

Yuriev, E., Capuano, B. & Short, J. L., 2016, In : Chemistry Education Research and Practice. 17, 3, p. 532-554 23 p.

Research output: Contribution to journalArticleResearchpeer-review

10 Citations (Scopus)

Determination of ligand binding modes in weak protein–ligand complexes using sparse NMR data

Mohanty, B., Williams, M., Doak, B. C., Vazirani, M., Ilyichova, O., Wang, G., Bermel, W., Simpson, J. S., Chalmers, D. K., King, G. F., Mobli, M. & Scanlon, M. J., Nov 2016, In : Journal of Biomolecular NMR. 66, 3, p. 195-208 14 p.

Research output: Contribution to journalArticleResearchpeer-review

1 Citation (Scopus)
6 Citations (Scopus)

Development of single and mixed isoform selectivity PI3Kδ inhibitors by targeting Asn836 of PI3Kδ

Miller, M. S., Mountford, S. J., Pinson, J-A., Zheng, Z., Künzli, M., Patel, V., Hogg, S. J., Shortt, J., Jennings, I. G. & Thompson, P. E., 1 Oct 2016, In : Bioorganic and Medicinal Chemistry Letters. 26, 19, p. 4790-4794 5 p.

Research output: Contribution to journalArticleResearchpeer-review

11 Citations (Scopus)

Discovery and antiplatelet activity of a selective PI3Kβ inhibitor (MIPS-9922)

Zheng, Z., Pinson, J. A., Mountford, S. J., Orive, S., Schoenwaelder, S. M., Shackleford, D., Powell, A., Nelson, E. M., Hamilton, J. R., Jackson, S., Jennings, I. G. & Thompson, P. E., 21 Oct 2016, In : European Journal of Medicinal Chemistry. 122, p. 339-351 13 p.

Research output: Contribution to journalArticleResearchpeer-review

55 Citations (Scopus)

Discovery and optimization of materials using evolutionary approaches

Le, T. C. & Winkler, D. A., 2016, In : Chemical Reviews. 116, 10, p. 6107-6132 26 p.

Research output: Contribution to journalArticleResearchpeer-review

11 Citations (Scopus)

Electrophilic Activation of P-Alkynes in the Synthesis of P-Substituted and P-Centered Heterocycles

Gupta, A. & Flynn, B. L., 20 May 2016, In : Journal of Organic Chemistry. 81, 10, p. 4012-4019 8 p.

Research output: Contribution to journalArticleResearchpeer-review

9 Citations (Scopus)

Enabling noninvasive systemic delivery of the Kv1.3-blocking peptide HsTX1[R14A] via the buccal mucosa

Jin, L., Boyd, B. J., Larson, I. C., Pennington, M. W., Norton, R. S. & Nicolazzo, J. A., 1 Jul 2016, In : Journal of Pharmaceutical Sciences. 105, 7, p. 2173-2179 7 p.

Research output: Contribution to journalArticleResearchpeer-review

13 Citations (Scopus)

Enantiomeric two-armed lanthanide-binding tags for complementary effects in paramagnetic NMR spectroscopy

Lee, M. D., Dennis, M. L., Swarbrick, J. D. & Graham, B., 2016, In : Chemical Communications. 52, 51, p. 7954-7957 4 p.

Research output: Contribution to journalArticleResearchpeer-review

26 Citations (Scopus)

Extracellular loop 2 of the adenosine A1 receptor has a key role in orthosteric ligand affinity and agonist efficacy

Nguyen, A. T. N., Baltos, J-A., Thomas, T., Nguyen, T. D., Lopez Munoz, L., Gregory, K. J., White, P. J., Sexton, P. M., Christopoulos, A. & May, L. T., 1 Dec 2016, In : Molecular Pharmacology. 90, 6, p. 703-714 12 p.

Research output: Contribution to journalArticleResearchpeer-review

22 Citations (Scopus)
16 Citations (Scopus)

Flipped classroom implementation: A case report of two higher education institutions in the United States and Australia

McLaughlin, J. E., White, P. J., Khanova, J. & Yuriev, E., 2016, In : Computers in the Schools. 33, 1, p. 24-37 14 p.

Research output: Contribution to journalArticleResearchpeer-review

5 Citations (Scopus)

Fragment based strategies for discovery of novel HIV-1 reverse transcriptase and integrase inhibitors

Latham, C. F., La, J., Tinetti, R. N., Chalmers, D. K. & Tachedjian, G., 2016, In : Current Topics in Medicinal Chemistry. 16, 10, p. 1135-1153 19 p.

Research output: Contribution to journalArticleResearchpeer-review

18 Citations (Scopus)

From sphingosine kinase to dihydroceramide desaturase: a structure-activity relationship (SAR) study of the enzyme inhibitory and anticancer activity of 4-((4-(4-chlorophenyl)thiazol-2-yl)amino)phenol (SKI-II)

Aurelio, L., Scullino, C. V., Pitman, M. R., Sexton, A. E., Oliver, V., Davies, L., Rebello, R. J., Furic, L., Creek, D. J., Pitson, S. M. & Flynn, B. L., 11 Feb 2016, In : Journal of Medicinal Chemistry. 59, 3, p. 965-984 20 p.

Research output: Contribution to journalArticleResearchpeer-review

16 Citations (Scopus)

Glyceride-mimetic prodrugs incorporating self-immolative spacers promote lymphatic transport, avoid first-pass metabolism, and enhance oral bioavailability

Hu, L., Quach, T., Han, S., Lim, S. F., Yadav, P., Senyschyn, D., Trevaskis, N. L., Simpson, J. S. & Porter, C. J. H., 2016, In : Angewandte Chemie - International Edition. 55, 44, p. 13700 –13705 6 p.

Research output: Contribution to journalArticleResearchpeer-review

15 Citations (Scopus)

Hit-to-lead optimization of a novel class of potent, broad-spectrum trypanosomacides

Russell, S., Rahmani, R., Jones, A. J., Newson, H. L., Neilde, K., Cotillo, I., Rahmani Khajouei, M., Ferrins, L., Qureishi, S., Nguyen, N., Martinez-Martinez, M. S., Weaver, D. F., Kaiser, M., Riley, J., Thomas, J., De Rycker, M., Read, K. D., Flematti, G. R., Ryan, E., Tanghe, S. & 6 others, Rodriguez, A., Charman, S. A., Kessler, A., Avery, V. M., Baell, J. B. & Piggott, M. J., 10 Nov 2016, In : Journal of Medicinal Chemistry. 59, 21, p. 9686-9720 35 p.

Research output: Contribution to journalArticleResearchpeer-review

2 Citations (Scopus)

Identification of a cyanine-dye labeled peptidic ligand for Y1R and Y4R, based upon the neuropeptide y C-terminal analogue, BVD-15

Liu, M., Richardson, R. R., Mountford, S. J., Zhang, L., Tempone, M. H., Herzog, H., Holliday, N. D. & Thompson, P. E., 21 Sep 2016, In : Bioconjugate Chemistry. 27, 9, p. 2166-2175 10 p.

Research output: Contribution to journalArticleResearchpeer-review

2 Citations (Scopus)

Implications of the complete basis set limit in valence bond theory: a case study of molecular hydrogen

Duke, B. J. & Havenith, R. W. A., 1 Mar 2016, In : Theoretical Chemistry Accounts. 135, 3, 9 p., 82.

Research output: Contribution to journalArticleResearchpeer-review

7 Citations (Scopus)

Installation of a rigid EDTA-like motif into a protein α-helix for paramagnetic NMR spectroscopy with cobalt(II) ions

Swarbrick, J. D., Ung, P., Dennis, M. L., Lee, M. D., Chhabra, S. & Graham, B., 22 Jan 2016, In : Chemistry - A European Journal. 22, 4, p. 1228-1232 5 p.

Research output: Contribution to journalArticleResearchpeer-review

8 Citations (Scopus)

Legumain is activated in macrophages during pancreatitis

Edgington-Mitchell, L. E., Wartmann, T., Fleming, A. K., Gocheva, V., van der Linden, W. A., Withana, N. P., Verdoes, M., Aurelio, L., Edgington-Mitchell, D., Lieu, T., Parker, B. S., Graham, B., Reinheckel, T., Furness, J. B., Joyce, J. A., Storz, P., Halangk, W., Bogyo, M. & Bunnett, N. W., Sep 2016, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 311, 3, p. G548-G560 13 p.

Research output: Contribution to journalArticleResearchpeer-review

18 Citations (Scopus)

Ligand binding pathways of clozapine and haloperidol in the dopamine D2 and D3 receptors

Thomas, T., Yuriev, E. & Chalmers, D. K., 22 Feb 2016, In : Journal of Chemical Information and Modeling. 56, 2, p. 308-321 14 p.

Research output: Contribution to journalArticleResearchpeer-review

14 Citations (Scopus)

Luminescent alkyne-bearing terbium(III) complexes and their application to bioorthogonal protein labeling

O'Malley, W., Abdelkader, E. H., Aulsebrook, M., Rubbiani, R., Loh, C. T., Grace, M., Spiccia, L., Gasser, G., Otting, G., Tuck, K. & Graham, B., 15 Feb 2016, In : Inorganic Chemistry. 55, 4, p. 1674-1682 9 p.

Research output: Contribution to journalArticleResearchpeer-review

10 Citations (Scopus)

Lymphatic transport and lymphocyte targeting of a triglyceride mimetic prodrug is enhanced in a large animal model: studies in greyhound dogs

Han, S., Hu, L., Gracia, G., Quach, T., Simpson, J. S., Edwards, G. A., Trevaskis, N. L. & Porter, C. J. H., 3 Oct 2016, In : Molecular Pharmaceutics. 13, 10, p. 3351-3361 11 p.

Research output: Contribution to journalArticleResearchpeer-review

9 Citations (Scopus)

Metabolomics and lipidomics reveal perturbation of sphingolipid metabolism by a novel anti-trypanosomal 3-(oxazolo[4,5-b]pyridine-2-yl)anilide

Stoessel, D., Nowell, C. J., Jones, A. J., Ferrins, L., Ellis, K. M., Riley, J., Rahmani, R., Read, K. D., McConville, M. J., Avery, V. M., Baell, J. B. & Creek, D. J., 1 Jul 2016, In : Metabolomics. 12, 7, 14 p., 126.

Research output: Contribution to journalArticleResearchpeer-review

4 Citations (Scopus)

Modeling the influence of fatty acid incorporation on mesophase formation in amphiphilic therapeutic delivery systems

Le, T. C., Tran, N., Mulet, X. & Winkler, D. A., 2016, In : Molecular Pharmaceutics. 13, 3, p. 996-1003 8 p.

Research output: Contribution to journalArticleResearchpeer-review

4 Citations (Scopus)

Neomycin B-cyclen conjugates and their Zn(II) complexes as RNA-binding agents

Kong, B., Joshi, T., Belousoff, M. J., Tor, Y., Graham, B. & Spiccia, L., 2016, In : Journal of Inorganic Biochemistry. 162, p. 334-342 9 p.

Research output: Contribution to journalArticleResearchpeer-review

22 Citations (Scopus)

Neutron reflection study of the interaction of the eukaryotic pore-forming actinoporin equinatoxin II with lipid membranes reveals intermediate states in pore formation

Wacklin, H. P., Bremec, B. B., Moulin, M., Rojko, N., Haertlein, M., Forsyth, T., Anderluh, G. & Norton, R., 1 Apr 2016, In : Biochimica et Biophysica Acta - Biomembranes. 1858, 4, p. 640-652 13 p.

Research output: Contribution to journalArticleResearchpeer-review

5 Citations (Scopus)

New synthetic approaches towards analogues of bedaquiline

Priebbenow, D. L., Barbaro, L. & Baell, J. B., 28 Oct 2016, In : Organic and Biomolecular Chemistry. 14, 40, p. 9622-9628 7 p.

Research output: Contribution to journalArticleResearchpeer-review

8 Citations (Scopus)

Novel fused arylpyrimidinone based allosteric modulators of the M1 muscarinic acetylcholine receptor

Mistry, S. N., Lim, H., Jorg, M., Capuano, B., Christopoulos, A., Lane, J. R. & Scammells, P. J., 18 May 2016, In : ACS Chemical Neuroscience. 7, 5, p. 647-661 15 p.

Research output: Contribution to journalArticleResearchpeer-review

7 Citations (Scopus)

Novel irreversible agonists acting at the A1 adenosine receptor

Jorg, M., Glukhova, A., Abdul Ridha, A., Vecchio, E. A., Nguyen, A., Sexton, P., White, P., May, L., Christopoulos, A. & Scammells, P., 22 Dec 2016, In : Journal of Medicinal Chemistry. 59, 24, p. 11182-11194 13 p.

Research output: Contribution to journalArticleResearchpeer-review

27 Citations (Scopus)

Open source drug discovery: Highly potent antimalarial compounds derived from the tres cantos arylpyrroles

Williamson, A. E., Ylioja, P. M., Robertson, M. N., Antonova-Koch, Y., Avery, V., Baell, J., Batchu, H., Batra, S., Burrows, J. N., Bhattacharyya, S., Calderon, F., Charman, S., Clark, J., Crespo, B., Dean, M., Debbert, S. L., Delves, M. J., Dennis, A. S. M., Deroose, F., Duffy, S. & 3 others, Ryan, E., Wells, T. & White, K., 26 Oct 2016, In : ACS Central Science. 2, 10, p. 687-701 15 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
7 Citations (Scopus)

Optically pure, structural, and fluorescent analogues of a dimeric Y4 receptor agonist derived by an olefin metathesis approach

Liu, M., Mountford, S. J., Richardson, R. R., Groenen, M., Holliday, N. D. & Thompson, P. E., 14 Jul 2016, In : Journal of Medicinal Chemistry. 59, 13, p. 6059-6069 11 p.

Research output: Contribution to journalArticleResearchpeer-review

14 Citations (Scopus)

Overcoming artificial broadening in Gd3+-Gd3+ distance distributions arising from dipolar pseudo-secular terms in DEER experiments

Cohen, M. F. R., Frydman, V., Milko, P., Iron, M. A., Abdelkader, E. H., Lee, M. D., Swarbrick, J. D., Raitsimring, A., Otting, G., Graham, B., Feintuch, A. & Goldfarb, D., 2016, In : Physical Chemistry Chemical Physics. 18, 18, p. 12847-12859 13 p.

Research output: Contribution to journalArticleResearchpeer-review

7 Citations (Scopus)

Phosphorylation of the dimeric cytoplasmic domain of the phytosulfokine receptor, PSKR1

Muleya, V., Marondedze, C., Wheeler, J. I., Thomas, L., Mok, Y. F., Griffin, M. D. W., Manallack, D. T., Kwezi, L., Lilley, K. S., Gehring, C. & Irving, H. R., 2016, In : Biochemical Journal. 473, 19, p. 3081-3098 18 p.

Research output: Contribution to journalArticleResearchpeer-review