Research Output 1977 2019

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2017
16 Citations (Scopus)

Investigation of donor-acceptor Stenhouse adducts as new visible wavelength-responsive switching elements for lipid-based liquid crystalline systems

Jia, S., Du, J. D., Hawley, A., Fong, W-K., Graham, B. & Boyd, B. J., 7 Mar 2017, In : Langmuir: the ACS journal of surfaces and colloids. 33, 9, p. 2215-2221 7 p.

Research output: Contribution to journalArticleResearchpeer-review

9 Citations (Scopus)

Ionic Liquid Forms of Weakly Acidic Drugs in Oral Lipid Formulations: Preparation, Characterization, in Vitro Digestion, and in Vivo Absorption Studies

Sahbaz, Y., Nguyen, T. H., Ford, L., McEvoy, C. L., Williams, H. D., Scammells, P. J. & Porter, C. J. H., 6 Nov 2017, In : Molecular Pharmaceutics. 14, 11, p. 3669-3683 15 p.

Research output: Contribution to journalArticleResearchpeer-review

10 Citations (Scopus)

Isoform-specific biased agonism of histamine H3 receptor agonists

Riddy, D. M., Cook, A. E., Diepenhorst, N. A., Bosnyak, S., Brady, R., La Cour, C. M., Mocaer, E., Summers, R. J., Charman, W. N., Sexton, P. M., Christopoulos, A. & Langmead, C. J., 1 Feb 2017, In : Molecular Pharmacology. 91, 2, p. 87-99 13 p.

Research output: Contribution to journalArticleResearchpeer-review

6 Citations (Scopus)

Linear and Angular Heteroacenes from Double-Electrophilic Cyclization (DEC) and DEC-Reductive Elimination of Diynes

Gupta, A. & Flynn, B. L., 21 Apr 2017, In : Organic Letters. 19, 8, p. 1939-1941 3 p.

Research output: Contribution to journalArticleResearchpeer-review

4 Citations (Scopus)

Lipid interactions modulate the structural and antigenic properties of the C-terminal domain of the malaria antigen merozoite surface protein 2

Das, S. C., Morales, R. A. V., Seow, J., Krishnarjuna, B., Dissanayake, R., Anders, R. F., Macraild, C. A. & Norton, R. S., 2017, In : FEBS Journal. 284, 16, p. 649–2662 14 p.

Research output: Contribution to journalArticleResearchpeer-review

45 Citations (Scopus)

Materials genome in action: identifying the performance limits of physical hydrogen storage

Thornton, A. W., M. Simon, C., Kim, J., Kwon, O., S. Deeg, K., Konstas, K., Pas, S. J., Hill, M. R., Winkler, D. A., Haranczyk, M. & Smit, B., Apr 2017, In : Chemistry of Materials. 29, 7, p. 2844-2854 11 p.

Research output: Contribution to journalArticleResearchpeer-review

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10 Citations (Scopus)

Mechanisms of Carbonyl Activation by BINOL N-Triflylphosphoramides: Enantioselective Nazarov Cyclizations

Lovie-Toon, J. P., Tram, C. M., Flynn, B. L. & Krenske, E. H., 5 May 2017, In : ACS Catalysis. 7, 5, p. 3466-3476 11 p.

Research output: Contribution to journalArticleResearchpeer-review

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Modulating the activity of membrane-active peptides through Zn(II) complexation

Paquet-Côté, P. A., Tuck, K. L., Paradis, J. P., Graham, B. & Voyer, N., 13 Dec 2017, In : Tetrahedron Letters. 58, 50, p. 4672-4676 5 p.

Research output: Contribution to journalArticleResearchpeer-review

4 Citations (Scopus)

Molecular insights into the interaction between the SPRY domain-containing SOCS box protein SPSB2 and peptides based on the binding motif from iNOS

Leung, E., Mulcair, M., Yap, S., Nicholson, S. E., Scanlon, M. & Norton, R., 2017, In : Australian Journal of Chemistry. 70, 2, p. 191-200 10 p.

Research output: Contribution to journalArticleResearchpeer-review

2 Citations (Scopus)

Molecular simulations of carbohydrates with a fucose-binding Burkholderia ambifaria lectin suggest modulation by surface residues outside the fucose-binding pocket

Dingjan, T., Imberty, A., Pérez, S., Yuriev, E. & Ramsland, P. A., 21 Jun 2017, In : Frontiers in Pharmacology. 8, JUN, 393.

Research output: Contribution to journalArticleResearchpeer-review

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14 Citations (Scopus)

Multistereocenter-Containing Cyclopentanoids from Ynamides via Oxazolidinone-Controlled Nazarov Cyclization

Manchala, N., Law, H. Y. L., Kerr, D. J., Volpe, R., Lepage, R. J., White, J. M., Krenske, E. H. & Flynn, B. L., 7 Jul 2017, In : Journal of Organic Chemistry. 82, 13, p. 6511-6527 17 p.

Research output: Contribution to journalArticleResearchpeer-review

44 Citations (Scopus)

Neurokinin 1 receptor signaling in endosomes mediates sustained nociception and is a viable therapeutic target for prolonged pain relief

Jensen, D. D., Lieu, T., Halls, M. L., Veldhuis, N. A., Imlach, W. L., Mai, Q. N., Poole, D. P., Quach, T., Aurelio, L., Conner, J., Klein Herenbrink, C., Barlow, N., Simpson, J. S., Scanlon, M. J., Graham, B., McCluskey, A., Robinson, P. J., Escriou, V., Nassini, R., Materazzi, S. & 6 others, Geppetti, P., Hicks, G. A., Christie, M. J., Porter, C. J. H., Canals, M. & Bunnett, N. W., 31 May 2017, In : Science Translational Medicine. 9, 392, 15 p., aal3447.

Research output: Contribution to journalArticleResearchpeer-review

7 Citations (Scopus)

New lanthanide tag for the generation of pseudocontact shifts in DNA by site-specific ligation to a phosphorothioate group

Wu, Z., Lee, M. D., Carruthers, T. J., Szabo, M., Dennis, M. L., Swarbrick, J. D., Graham, B. & Otting, G., 21 Jun 2017, In : Bioconjugate Chemistry. 28, 6, p. 1741−1748 8 p.

Research output: Contribution to journalArticleResearchpeer-review

15 Citations (Scopus)

Optimization of 2-anilino 4-amino substituted quinazolines into potent antimalarial agents with oral in vivo activity

Gilson, P. R., Tan, C., Jarman, K. E., Lowes, K. N., Curtis, J. M., Nguyen, W., Di Rago, A. E., Bullen, H. E., Prinz, B., Duffy, S., Baell, J. B., Hutton, C. A., Jousset Subroux, H., Crabb, B. S., Avery, V. M., Cowman, A. F. & Sleebs, B. E., 9 Feb 2017, In : Journal of Medicinal Chemistry. 60, 3, p. 1171-1188 18 p.

Research output: Contribution to journalArticleResearchpeer-review

13 Citations (Scopus)

Parallel and antiparallel cyclic d/l peptide nanotubes

Silk, M. R., Newman, J., Ratcliffe, J. C., White, J. F., Caradoc-Davies, T., Price, J. R., Perrier, S., Thompson, P. E. & Chalmers, D. K., 2017, In : Chemical Communications. 53, 49, p. 6613-6616 4 p.

Research output: Contribution to journalArticleResearchpeer-review

21 Citations (Scopus)

Performance of Deep and Shallow Neural Networks, the Universal Approximation Theorem, Activity Cliffs, and QSAR

Winkler, D. & Le, T. C., 1 Jan 2017, In : Molecular Informatics. 36, 1-2, 6 p., 1600118.

Research output: Contribution to journalArticleResearchpeer-review

9 Citations (Scopus)

Pharmacokinetics of the individual major components of polymyxin B and colistin in rats

Sivanesan, S., Roberts, K., Wang, J., Cheah, S-E., Thompson, P. E., Li, J., Nation, R. & Velkov, T., 27 Jan 2017, In : Journal of Natural Products. 80, 1, p. 225-229 5 p.

Research output: Contribution to journalArticleResearchpeer-review

4 Citations (Scopus)

Precise control of drug loading and release of an NSAID-polymer conjugate for long term osteoarthritis intra-articular drug delivery

Sulistio, A., Reyes-Ortega, F., D'Souza, A. M., Ng, S. M. Y., Valade, D., Quinn, J. F., Donohue, A. C., Mansfeld, F., Blencowe, A., Qiao, G., Prankerd, R., Quirk, S., Whittaker, M. R., Davis, T. P. & Tait, R. J., 1 Jan 2017, In : Journal of Materials Chemistry B. 5, 31, p. 6221-6226 6 p.

Research output: Contribution to journalArticleResearchpeer-review

14 Citations (Scopus)

Prolonged immunomodulation in inflammatory arthritis using the selective Kv1.3 channel blocker HsTX1[R14A] and its PEGylated analog

Tanner, M. R., Tajhya, R. B., Huq, R., Gehrmann, E. J., Rodarte, K. E., Atik, M. A., Norton, R. S., Pennington, M. W. & Beeton, C., 1 Jul 2017, In : Clinical Immunology. 180, p. 45-57 13 p.

Research output: Contribution to journalArticleResearchpeer-review

1 Citation (Scopus)

Purification and characterization of adenovirus core protein VII: A histone-like protein that is critical for adenovirus core formation

Sharma, G., Moria, N., Williams, M., Krishnarjuna, B. & Pouton, C. W., 1 Jul 2017, In : Journal of General Virology. 98, 7, p. 1785-1794 10 p., 000817.

Research output: Contribution to journalArticleResearchpeer-review

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3 Citations (Scopus)

Reinvestigation of the biological activity of D-allo-ShK protein

Dang, B., Chhabra, S., Pennington, M. W., Norton, R. S. & Kent, S. B. H., 2017, In : Journal of Biological Chemistry. 292, 30, p. 12599-12605 7 p.

Research output: Contribution to journalArticleResearchpeer-review

6 Citations (Scopus)

Scaffolding the development of problem-solving skills in chemistry: Guiding novice students out of dead ends and false starts

Yuriev, E., Naidu, S., Schembri, L. S. & Short, J. L., 1 Jan 2017, In : Chemistry Education Research and Practice. 18, 3, p. 486-504 19 p.

Research output: Contribution to journalArticleResearchpeer-review

11 Citations (Scopus)

Screening of the ‘Open Scaffolds’ collection from Compounds Australia identifies a new chemical entity with anthelmintic activities against different developmental stages of the barber's pole worm and other parasitic nematodes

Preston, S., Jiao, Y., Baell, J. B., Keiser, J., Crawford, S., Koehler, A. V., Wang, T., Simpson, M. M., Kaplan, R. M., Cowley, K. J., Simpson, K. J., Hofmann, A., Jabbar, A. & Gasser, R. B., 1 Dec 2017, In : International Journal for Parasitology: Drugs and Drug Resistance. 7, 3, p. 286-294 9 p.

Research output: Contribution to journalArticleResearchpeer-review

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15 Citations (Scopus)

Selective Distance Measurements Using Triple Spin Labeling with Gd3+, Mn2+, and a Nitroxide

Wu, Z., Feintuch, A., Collauto, A., Adams, L. A., Aurelio, L., Graham, B., Otting, G. & Goldfarb, D., 2 Nov 2017, In : Journal of Physical Chemistry Letters. 8, 21, p. 5277-5282 6 p.

Research output: Contribution to journalArticleResearchpeer-review

27 Citations (Scopus)

Solution conformations of a linked construct of the Zika virus NS2B-NS3 protease

Mahawaththa, M. C., Pearce, B. J. G., Szabo, M., Graham, B., Klein, C. D., Nitsche, C. & Otting, G., 1 Jun 2017, In : Antiviral Research. 142, p. 141-147 7 p.

Research output: Contribution to journalArticleResearchpeer-review

7 Citations (Scopus)

Structure and activity of contryphan-Vc2: importance of the D-amino acid residue

Drane, S. B., Robinson, S. D., MacRaild, C., Chhabra, S., Chittoor, B., A V Morales, R., Leung, E. W. W., Belgi, A., Espino, S. S., Olivera, B. M., Robinson, A. J., Chalmers, D. K. & Norton, R. S., 1 Apr 2017, In : Toxicon : official journal of the International Society on Toxinology. 129, p. 113-122 10 p.

Research output: Contribution to journalArticleResearchpeer-review

4 Citations (Scopus)

Structure and Characterisation of a Key Epitope in the Conserved C-Terminal Domain of the Malaria Vaccine Candidate MSP2

Seow, J., A V Morales, R., MacRaild, C. A., Bankala, K., McGowan, S., Dingjan, T., Jaipuria, G., Rouet, R., Wilde, K., Atreya, H. S., Richards, J. S., Anders, R. F., Christ, D., Drinkwater, N. & Norton, R. S., 24 Mar 2017, In : Journal of Molecular Biology. 429, 6, p. 836-846 11 p.

Research output: Contribution to journalArticleResearchpeer-review

87 Citations (Scopus)

Structure of the adenosine A1 receptor reveals the basis for subtype selectivity

Glukhova, A., Thal, D. M., Nguyen, A. T., Vecchio, L., Jorg, M., Scammells, P. J., May, L. T., Sexton, P. M. & Christopoulos, A., 23 Feb 2017, In : Cell. 168, 5, p. 867-877.e13

Research output: Contribution to journalArticleResearchpeer-review

3 Citations (Scopus)

Structure restraints from heteronuclear pseudocontact shifts generated by lanthanide tags at two different sites

Pearce, B. J. G., Jabar, S., Loh, C-T., Szabo, M., Graham, B. & Otting, G., 1 May 2017, In : Journal of Biomolecular NMR. 68, 1, p. 19-32 14 p.

Research output: Contribution to journalArticleResearchpeer-review

10 Citations (Scopus)

Student engagement with a flipped classroom teaching design affects pharmacology examination performance in a manner dependent on question type

White, P. J., Naidu, S., Yuriev, E., Short, J. L., McLaughlin, J. E. & Larson, I. C., 2017, In : American Journal of Pharmaceutical Education. 81, 9, p. 10-23 14 p., 5931.

Research output: Contribution to journalArticleResearchpeer-review

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15 Citations (Scopus)

Studies of carbon monoxide release from ruthenium(II) bipyridine carbonyl complexes upon UV-light exposure

Kubeil, M., Vernooij, R. R., Kubeil, C., Wood, B. R., Graham, B., Stephan, H. & Spiccia, L., 15 May 2017, In : Inorganic Chemistry. 56, 10, p. 5941-5952 12 p.

Research output: Contribution to journalArticleResearchpeer-review

1 Citation (Scopus)

Synthesis and biological evaluation of 8-aryl-2-morpholino-7-O-substituted benzo[e][1,3]oxazin-4-ones against DNA-PK, PI3K, PDE3A enzymes and platelet aggregation

Saifuzzaman, M., Morrison, R., Zheng, Z., Orive, S., Hamilton, J., Thompson, P. E. & Al-Rawi, J. M. A., 15 Oct 2017, In : Bioorganic and Medicinal Chemistry. 25, 20, p. 5531-5536 6 p.

Research output: Contribution to journalArticleResearchpeer-review

4 Citations (Scopus)

The acid/base profile of agrochemicals

Manallack, D. T., 12 Aug 2017, In : SAR and QSAR in Environmental Research. 28, 8, p. 621-628 8 p.

Research output: Contribution to journalArticleResearchpeer-review

9 Citations (Scopus)

The cationic small molecule GW4869 is cytotoxic to high phosphatidylserine-expressing myeloma cells

Vuckovic, S., Vandyke, K., Rickards, D. A., Mccauley Winter, P., Brown, S. H. J., Mitchell, T. W., Liu, J., Lu, J., Askenase, P. W., Yuriev, E., Capuano, B., Ramsland, P., Hill, G. R., Zannettino, A. C. W. & Hutchinson, A. T., May 2017, In : British Journal of Haematology. 177, 3, p. 423-440 18 p.

Research output: Contribution to journalArticleResearchpeer-review

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3 Citations (Scopus)

The first total synthesis and solution structure of a polypeptin, PE2, a cyclic lipopeptide with broad spectrum antibiotic activity

Mountford, S. J., Mohanty, B., Roberts, K. D., Yu, H. H., Scanlon, M. J., Nation, R. L., Velkov, T., Li, J. & Thompson, P. E., 2017, In : Organic and Biomolecular Chemistry. 15, 34, p. 7173-7180 8 p.

Research output: Contribution to journalArticleResearchpeer-review

2 Citations (Scopus)

The Single Disulfide-Directed β-Hairpin Fold. Dynamics, Stability, and Engineering

Chittoor, B., Krishnarjuna, B., Morales, R. A. V., Macraild, C. A., Sadek, M. M., Leung, E. W. W., Robinson, S. D., Pennington, M. W. & Norton, R. S., 16 May 2017, In : Biochemistry. 56, 19, p. 2455-2466 12 p.

Research output: Contribution to journalArticleResearchpeer-review

9 Citations (Scopus)

The use of imaging mass spectrometry to study peptide toxin distribution in Australian sea anemones

Mitchell, M. L., Hamilton, B. R., Madio, B., Morales, R. A. V., Tonkin-Hill, G. Q., Papenfuss, A. T., Purcell, A. W., King, G. F., Undheim, E. A. B. & Norton, R. S., 2017, In : Australian Journal of Chemistry. 70, 11, p. 1235-1237 3 p.

Research output: Contribution to journalArticleResearchpeer-review

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3 Citations (Scopus)

Utility of iron nanoparticles and a solution-phase iron species for the N-demethylation of alkaloids

Awalt, J. K., Lam, R., Kellam, B., Graham, B., Scammells, P. J. & Singer, R. D., 2017, In : Green Chemistry. 19, 11, p. 2587-2594 8 p.

Research output: Contribution to journalArticleResearchpeer-review

23 Citations (Scopus)

Venom-derived peptide inhibitors of voltage-gated potassium channels

Norton, R. S. & Chandy, K. G., 2017, In : Neuropharmacology. 127, p. 124-138 15 p.

Research output: Contribution to journalArticleResearchpeer-review

6 Citations (Scopus)

X-ray crystal structure of plasmin with tranexamic acid–derived active site inhibitors

Law, R. H. P., Wu, G., Leung, E. W. W., Hidaka, K., Quek, A. J., Caradoc-Davies, T. T., Jeevarajah, D., Conroy, P. J., Kirby, N. M., Norton, R. S., Tsuda, Y. & Whisstock, J. C., 9 May 2017, In : Blood Advances. 1, 12, p. 766-771 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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8 Citations (Scopus)

Zwitterionic modification of ultrasmall iron oxide nanoparticles for reduced protein corona formation

Pombo-García, K., Rühl, C. L., Lam, R., Barreto, J. A., Ang, C-S., Scammells, P. J., Comba, P., Spiccia, L., Graham, B., Joshi, T. & Stephan, H., 2017, In : ChemPlusChem. 82, 4, p. 638–646 9 p.

Research output: Contribution to journalArticleResearchpeer-review

10 Citations (Scopus)

Δ-Myrtoxin-Mp1a is a Helical Heterodimer from the Venom of the Jack Jumper Ant that has Antimicrobial, Membrane-Disrupting, and Nociceptive Activities

Dekan, Z., Headey, S. J., Scanlon, M., Baldo, B. A., Lee, T-H., Aguilar, M-I., Deuis, J. R., Vetter, I., Elliott, A. G., Amado, M., Cooper, M. A., Alewood, D. & Alewood, P. F., 2017, In : Angewandte Chemie - International Edition. 56, 29, p. 8495-8499 6 p.

Research output: Contribution to journalArticleResearchpeer-review

2016
1 Citation (Scopus)

1H, 13C and 15N resonance assignments of a C-terminal domain of human CHD1

Mohanty, B., Silva, A. P. G., Mackay, J. P. & Ryan, D. P., 1 Apr 2016, In : Biomolecular NMR Assignments. 10, 1, p. 31-34 4 p.

Research output: Contribution to journalArticleOtherpeer-review

20 Citations (Scopus)

4-phenylpyridin-2-one derivatives: a novel class of positive allosteric modulator of the M1 muscarinic acetylcholine receptor

Mistry, S. N., Jorg, M., Lim, H., Vinh, N. B., Sexton, P. M., Capuano, B., Christopoulos, A., Lane, J. R. & Scammells, P. J., 14 Jan 2016, In : Journal of Medicinal Chemistry. 59, 1, p. 388-409 22 p.

Research output: Contribution to journalArticleResearchpeer-review

16 Citations (Scopus)

Accurate and interpretable nanoSAR models from genetic programming-based decision tree construction approaches

Oksel, C., Winkler, D. A., Ma, C. Y., Wilkins, T. & Wang, X. Z., 2016, In : Nanotoxicology. 10, 7, p. 1001-1012 12 p.

Research output: Contribution to journalArticleResearchpeer-review

16 Citations (Scopus)

Adopting an active learning approach to teaching in a research-intensive higher education context transformed staff teaching attitudes and behaviours

White, P. J., Larson, I., Styles, K., Yuriev, E., Evans, D. R., Rangachari, P. K., Short, J. L., Exintaris, B., Malone, D. T., Davie, B., Eise, N., McNamara, K. & Naidu, S., 2016, In : Higher Education Research and Development. 35, 3, p. 619-633 15 p.

Research output: Contribution to journalArticleResearchpeer-review

27 Citations (Scopus)

A minimized human insulin-receptor-binding motif revealed in a Conus geographus venom insulin

Menting, J. G., Gajewiak, J., MacRaild, C., Chou, D. H. C., Disotuar, M. M., Smith, N. A., Miller, C., Erchegyi, J., Rivier, J. E., Olivera, B. M., Forbes, B. E., Smith, B. J., Norton, R., Safavi-Hemami, H. & Lawrence, M. C., 1 Oct 2016, In : Nature Structural and Molecular Biology. 23, 10, p. 916-920 5 p.

Research output: Contribution to journalArticleResearchpeer-review

1 Citation (Scopus)

An alternative approach to the synthesis of peptides containing a cystathionine bridge

Harjani, J. R., Yap, B. K., Norton, R. S. & Baell, J. B., 9 Jun 2016, In : Tetrahedron. 72, 23, p. 3256-3261 6 p.

Research output: Contribution to journalArticleResearchpeer-review

10 Citations (Scopus)

A naturally occurring peptide with an elementary single disulfide-directed β-hairpin fold

Robinson, S., Chhabra, S., Belgi, A., Chittoor, B., Safavi-Hemami, H., Robinson, A. J., Papenfuss, A. T., Purcell, A. & Norton, R., 2 Feb 2016, In : Structure. 24, 2, p. 293-299 7 p.

Research output: Contribution to journalArticleResearchpeer-review

19 Citations (Scopus)

An Experimental and Computational Approach to the Development of ZnO Nanoparticles that are Safe by Design

Le, T. C., Yin, H., Chen, R., Chen, Y., Zhao, L., Casey, P. S., Chen, C. & Winkler, D. A., 2016, In : Small. 12, 26, p. 3568-3577 10 p.

Research output: Contribution to journalArticleResearchpeer-review