Research Output 1977 2019

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2017

Studies of carbon monoxide release from ruthenium(II) bipyridine carbonyl complexes upon UV-light exposure

Kubeil, M., Vernooij, R. R., Kubeil, C., Wood, B. R., Graham, B., Stephan, H. & Spiccia, L., 15 May 2017, In : Inorganic Chemistry. 56, 10, p. 5941-5952 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Synthesis and biological evaluation of 8-aryl-2-morpholino-7-O-substituted benzo[e][1,3]oxazin-4-ones against DNA-PK, PI3K, PDE3A enzymes and platelet aggregation

Saifuzzaman, M., Morrison, R., Zheng, Z., Orive, S., Hamilton, J., Thompson, P. E. & Al-Rawi, J. M. A., 15 Oct 2017, In : Bioorganic and Medicinal Chemistry. 25, 20, p. 5531-5536 6 p.

Research output: Contribution to journalArticleResearchpeer-review

The acid/base profile of agrochemicals

Manallack, D. T., 12 Aug 2017, In : SAR and QSAR in Environmental Research. 28, 8, p. 621-628 8 p.

Research output: Contribution to journalArticleResearchpeer-review

The cationic small molecule GW4869 is cytotoxic to high phosphatidylserine-expressing myeloma cells

Vuckovic, S., Vandyke, K., Rickards, D. A., Mccauley Winter, P., Brown, S. H. J., Mitchell, T. W., Liu, J., Lu, J., Askenase, P. W., Yuriev, E., Capuano, B., Ramsland, P., Hill, G. R., Zannettino, A. C. W. & Hutchinson, A. T., May 2017, In : British Journal of Haematology. 177, 3, p. 423-440 18 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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The first total synthesis and solution structure of a polypeptin, PE2, a cyclic lipopeptide with broad spectrum antibiotic activity

Mountford, S. J., Mohanty, B., Roberts, K. D., Yu, H. H., Scanlon, M. J., Nation, R. L., Velkov, T., Li, J. & Thompson, P. E., 2017, In : Organic and Biomolecular Chemistry. 15, 34, p. 7173-7180 8 p.

Research output: Contribution to journalArticleResearchpeer-review

The Single Disulfide-Directed β-Hairpin Fold. Dynamics, Stability, and Engineering

Chittoor, B., Krishnarjuna, B., Morales, R. A. V., Macraild, C. A., Sadek, M. M., Leung, E. W. W., Robinson, S. D., Pennington, M. W. & Norton, R. S., 16 May 2017, In : Biochemistry. 56, 19, p. 2455-2466 12 p.

Research output: Contribution to journalArticleResearchpeer-review

The use of imaging mass spectrometry to study peptide toxin distribution in Australian sea anemones

Mitchell, M. L., Hamilton, B. R., Madio, B., Morales, R. A. V., Tonkin-Hill, G. Q., Papenfuss, A. T., Purcell, A. W., King, G. F., Undheim, E. A. B. & Norton, R. S., 2017, In : Australian Journal of Chemistry. 70, 11, p. 1235-1237 3 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Utility of iron nanoparticles and a solution-phase iron species for the N-demethylation of alkaloids

Awalt, J. K., Lam, R., Kellam, B., Graham, B., Scammells, P. J. & Singer, R. D., 2017, In : Green Chemistry. 19, 11, p. 2587-2594 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Venom-derived peptide inhibitors of voltage-gated potassium channels

Norton, R. S. & Chandy, K. G., 2017, In : Neuropharmacology. 127, p. 124-138 15 p.

Research output: Contribution to journalArticleResearchpeer-review

X-ray crystal structure of plasmin with tranexamic acid-derived active site inhibitors

Law, R. H. P., Wu, G., Leung, E. W. W., Hidaka, K., Quek, A. J., Caradoc-Davies, T. T., Jeevarajah, D., Conroy, P. J., Kirby, N. M., Norton, R. S., Tsuda, Y. & Whisstock, J. C., 2017, In : Blood Advances. 1, 12, p. 766-771 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Zwitterionic modification of ultrasmall iron oxide nanoparticles for reduced protein corona formation

Pombo-García, K., Rühl, C. L., Lam, R., Barreto, J. A., Ang, C-S., Scammells, P. J., Comba, P., Spiccia, L., Graham, B., Joshi, T. & Stephan, H., 2017, In : ChemPlusChem. 82, 4, p. 638–646 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Δ-Myrtoxin-Mp1a is a Helical Heterodimer from the Venom of the Jack Jumper Ant that has Antimicrobial, Membrane-Disrupting, and Nociceptive Activities

Dekan, Z., Headey, S. J., Scanlon, M., Baldo, B. A., Lee, T-H., Aguilar, M-I., Deuis, J. R., Vetter, I., Elliott, A. G., Amado, M., Cooper, M. A., Alewood, D. & Alewood, P. F., 2017, In : Angewandte Chemie - International Edition. 56, 29, p. 8495-8499 6 p.

Research output: Contribution to journalArticleResearchpeer-review

2016

1H, 13C and 15N resonance assignments of a C-terminal domain of human CHD1

Mohanty, B., Silva, A. P. G., Mackay, J. P. & Ryan, D. P., 1 Apr 2016, In : Biomolecular NMR Assignments. 10, 1, p. 31-34 4 p.

Research output: Contribution to journalArticleOtherpeer-review

4-phenylpyridin-2-one derivatives: a novel class of positive allosteric modulator of the M1 muscarinic acetylcholine receptor

Mistry, S. N., Jorg, M., Lim, H., Vinh, N. B., Sexton, P. M., Capuano, B., Christopoulos, A., Lane, J. R. & Scammells, P. J., 14 Jan 2016, In : Journal of Medicinal Chemistry. 59, 1, p. 388-409 22 p.

Research output: Contribution to journalArticleResearchpeer-review

Accurate and interpretable nanoSAR models from genetic programming-based decision tree construction approaches

Oksel, C., Winkler, D. A., Ma, C. Y., Wilkins, T. & Wang, X. Z., 2016, In : Nanotoxicology. 10, 7, p. 1001-1012 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Adopting an active learning approach to teaching in a research-intensive higher education context transformed staff teaching attitudes and behaviours

White, P. J., Larson, I., Styles, K., Yuriev, E., Evans, D. R., Rangachari, P. K., Short, J. L., Exintaris, B., Malone, D. T., Davie, B., Eise, N., McNamara, K. & Naidu, S., 2016, In : Higher Education Research and Development. 35, 3, p. 619-633 15 p.

Research output: Contribution to journalArticleResearchpeer-review

A minimized human insulin-receptor-binding motif revealed in a Conus geographus venom insulin

Menting, J. G., Gajewiak, J., MacRaild, C., Chou, D. H. C., Disotuar, M. M., Smith, N. A., Miller, C., Erchegyi, J., Rivier, J. E., Olivera, B. M., Forbes, B. E., Smith, B. J., Norton, R., Safavi-Hemami, H. & Lawrence, M. C., 1 Oct 2016, In : Nature Structural and Molecular Biology. 23, 10, p. 916-920 5 p.

Research output: Contribution to journalArticleResearchpeer-review

An alternative approach to the synthesis of peptides containing a cystathionine bridge

Harjani, J. R., Yap, B. K., Norton, R. S. & Baell, J. B., 9 Jun 2016, In : Tetrahedron. 72, 23, p. 3256-3261 6 p.

Research output: Contribution to journalArticleResearchpeer-review

A naturally occurring peptide with an elementary single disulfide-directed β-hairpin fold

Robinson, S., Chhabra, S., Belgi, A., Chittoor, B., Safavi-Hemami, H., Robinson, A. J., Papenfuss, A. T., Purcell, A. & Norton, R., 2 Feb 2016, In : Structure. 24, 2, p. 293-299 7 p.

Research output: Contribution to journalArticleResearchpeer-review

An Experimental and Computational Approach to the Development of ZnO Nanoparticles that are Safe by Design

Le, T. C., Yin, H., Chen, R., Chen, Y., Zhao, L., Casey, P. S., Chen, C. & Winkler, D. A., 2016, In : Small. 12, 26, p. 3568-3577 10 p.

Research output: Contribution to journalArticleResearchpeer-review

A novel chemical biology approach for mapping of polymyxin lipopeptide antibody binding epitopes

Velkov, T., Yun, B., Schneider, E. K., Azad, M. A. K., Dolezal, O., Morris, F. C., Nation, R. L., Wang, J., Chen, K., Yu, H., Wang, L., Thompson, P. E., Roberts, K. D. & Li, J., 2016, In : ACS Infectious Diseases. 2, 5, p. 341-351 11 p.

Research output: Contribution to journalArticleResearchpeer-review

A novel compound which sensitizes BRAF wild-type melanoma cells to vemurafenib in a TRIM16-dependent manner

Sutton, S. K., Carter, D. R., Kim, P., Tan, O., Arndt, G. M., Zhang, X. D., Baell, J., Noll, B. D., Wang, S., Kumar, N., McArthur, G. A., Cheung, B. B. & Marshall, G. M., 1 Aug 2016, In : Oncotarget. 7, 32, p. 52166-52178 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

A novel serpin regulatory mechanism: SERPINB9 is reversibly inhibited by vicinal disulfide bond formation in the reactive center loop

Mangan, M. S. J., Bird, C. H., Kaiserman, D., Matthews, A. Y., Hitchen, C., Steer, D. L., Thompson, P. E. & Bird, P. I., 12 Feb 2016, In : Journal of Biological Chemistry. 291, 7, p. 3626-3638 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Antagonism of the proinflammatory and pronociceptive actions of canonical and biased agonists of protease-activated receptor-2

Lieu, T., Savage, E., Zhao, P., Edgington-Mitchell, L., Barlow, N., Bron, R., Poole, D. P., McLean, P., Lohman, R. J., Fairlie, D. P. & Bunnett, N. W., 1 Sep 2016, In : British Journal of Pharmacology. 173, 18, p. 2752-2765 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Antibody recognition of disordered antigens

Macraild, C. A., Richards, J. S., Anders, R. F. & Norton, R. S., 5 Jan 2016, In : Structure. 24, 1, p. 148-157 10 p.

Research output: Contribution to journalArticleResearchpeer-review

A renaissance of neural networks in drug discovery

Baskin, I. I., Winkler, D. & Tetko, I. V., 2016, In : Expert Opinion on Drug Delivery. 11, 8, p. 785-795 11 p.

Research output: Contribution to journalArticleResearchpeer-review

A thrombopoietin receptor antagonist is capable of depleting myelofibrosis hematopoietic stem and progenitor cells

Wang, X., Haylock, D., Hu, C. S., Kowalczyk, W., Jiang, T., Qiu, J., Mosoyan, G., He, W., Marshall, N., Mascarenhas, J., Tarasova, A., Brody, J., Winkler, D. & Hoffman, R., 30 Jun 2016, In : Blood. 127, 26, p. 3398-3409 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Beta amino acid-modified and fluorescently labelled kisspeptin analogues with potent KISS1R activity

Camerino, M., Liu, M., Moriya, S., Kitahashi, T., Mahgoub, A., Mountford, S., Chalmers, D. K., Soga, T., Parhar, I. & Thompson, P., 1 Jun 2016, In : Journal of Peptide Science. 22, 6, p. 406-414 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Binding of CFA/I pili of enterotoxigenic Escherichia coli to asialo-GM1 is mediated by the minor pilin CfaE

Madhavan, T. P. V., Riches, J. D., Scanlon, M. J., Ulett, G. C. & Sakellaris, H., 1 May 2016, In : Infection and Immunity. 84, 5, p. 1642-1649 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Cell permeability beyond the rule of 5

Matsson, P., Doak, B. C., Over, B. & Kihlberg, J., 1 Jun 2016, In : Advanced Drug Delivery Reviews. 101, p. 42-61 20 p.

Research output: Contribution to journalArticleResearchpeer-review

Cellular uptake and photo-cytotoxicity of a gadolinium(III)-DOTA-naphthalimide complex "clicked" to a lipidated tat peptide

O'Malley, W., Rubbiani, R., Aulsebrook, M., Grace, M., Spiccia, L., Tuck, K., Gasser, G. & Graham, B., 1 Feb 2016, In : Molecules. 21, 2, p. 1-16 16 p., 194.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Clickable Photoaffinity Ligands for Metabotropic Glutamate Receptor 5 Based on Select Acetylenic Negative Allosteric Modulators

Gregory, K., Velagaleti, R., Thal, D. M., Brady, R. M., Christopoulos, A., Conn, P. J. & Lapinsky, D. J., 15 Jul 2016, In : ACS Chemical Biology. 11, 7, p. 1870-1879 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Compound heterozygous FXN mutations and clinical outcome in Friedreich ataxia

Galea, C., Huq, A., Lockhart, P. J., Tai, G., Corben, L., Yiu, E. M., Gurrin, L. C., Lynch, D. R., Gelbard, S., Durr, A., Pousset, F., Parkinson, M., Labrum, R., Giunti, P., Perlman, S. L., Delatycki, M. & Evans-Galea, M. V., 2016, In : Annals of Neurology. 79, 3, p. 485-495 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Comprehensive vibrational spectroscopic investigation of trans,trans,trans-[Pt(N3)2(OH)2(py)2], a Pt(IV) diazido anticancer prodrug candidate

Vernooij, R. R., Joshi, T., Shaili, E., Kubeil, M., Appadoo, D. R. T., Izgorodina, E. I., Graham, B., Sadler, P. J., Wood, B. & Spiccia, L., 20 Jun 2016, In : Inorganic Chemistry. 55, 12, p. 5983-5992 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Crossword puzzles for chemistry education: Learning goals beyond vocabulary

Yuriev, E., Capuano, B. & Short, J. L., 2016, In : Chemistry Education Research and Practice. 17, 3, p. 532-554 23 p.

Research output: Contribution to journalArticleResearchpeer-review

Determination of ligand binding modes in weak protein–ligand complexes using sparse NMR data

Mohanty, B., Williams, M., Doak, B. C., Vazirani, M., Ilyichova, O., Wang, G., Bermel, W., Simpson, J. S., Chalmers, D. K., King, G. F., Mobli, M. & Scanlon, M. J., Nov 2016, In : Journal of Biomolecular NMR. 66, 3, p. 195-208 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Development of single and mixed isoform selectivity PI3Kδ inhibitors by targeting Asn836 of PI3Kδ

Miller, M. S., Mountford, S. J., Pinson, J-A., Zheng, Z., Künzli, M., Patel, V., Hogg, S. J., Shortt, J., Jennings, I. G. & Thompson, P. E., 1 Oct 2016, In : Bioorganic and Medicinal Chemistry Letters. 26, 19, p. 4790-4794 5 p.

Research output: Contribution to journalArticleResearchpeer-review

Discovery and antiplatelet activity of a selective PI3Kβ inhibitor (MIPS-9922)

Zheng, Z., Pinson, J. A., Mountford, S. J., Orive, S., Schoenwaelder, S. M., Shackleford, D., Powell, A., Nelson, E. M., Hamilton, J. R., Jackson, S., Jennings, I. G. & Thompson, P. E., 21 Oct 2016, In : European Journal of Medicinal Chemistry. 122, p. 339-351 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Discovery and optimization of materials using evolutionary approaches

Le, T. C. & Winkler, D. A., 2016, In : Chemical Reviews. 116, 10, p. 6107-6132 26 p.

Research output: Contribution to journalArticleResearchpeer-review

Electrophilic Activation of P-Alkynes in the Synthesis of P-Substituted and P-Centered Heterocycles

Gupta, A. & Flynn, B. L., 20 May 2016, In : Journal of Organic Chemistry. 81, 10, p. 4012-4019 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Enabling noninvasive systemic delivery of the Kv1.3-blocking peptide HsTX1[R14A] via the buccal mucosa

Jin, L., Boyd, B. J., Larson, I. C., Pennington, M. W., Norton, R. S. & Nicolazzo, J. A., 1 Jul 2016, In : Journal of Pharmaceutical Sciences. 105, 7, p. 2173-2179 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Enantiomeric two-armed lanthanide-binding tags for complementary effects in paramagnetic NMR spectroscopy

Lee, M. D., Dennis, M. L., Swarbrick, J. D. & Graham, B., 2016, In : Chemical Communications. 52, 51, p. 7954-7957 4 p.

Research output: Contribution to journalArticleResearchpeer-review

Extracellular loop 2 of the adenosine A1 receptor has a key role in orthosteric ligand affinity and agonist efficacy

Nguyen, A. T. N., Baltos, J-A., Thomas, T., Nguyen, T. D., Lopez Munoz, L., Gregory, K. J., White, P. J., Sexton, P. M., Christopoulos, A. & May, L. T., 1 Dec 2016, In : Molecular Pharmacology. 90, 6, p. 703-714 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Fatty acid-binding protein 5 at the blood–brain barrier regulates endogenous brain docosahexaenoic acid levels and cognitive function

Pan, Y., Short, J. L., Choy, K. H. C., Zeng, A. X., Marriott, P. J., Owada, Y., Scanlon, M. J., Porter, C. J. H. & Nicolazzo, J. A., 16 Nov 2016, In : Journal of Neuroscience. 36, 46, p. 11755-11767 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Flipped classroom implementation: A case report of two higher education institutions in the United States and Australia

McLaughlin, J. E., White, P. J., Khanova, J. & Yuriev, E., 2016, In : Computers in the Schools. 33, 1, p. 24-37 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Fragment based strategies for discovery of novel HIV-1 reverse transcriptase and integrase inhibitors

Latham, C. F., La, J., Tinetti, R. N., Chalmers, D. K. & Tachedjian, G., 2016, In : Current Topics in Medicinal Chemistry. 16, 10, p. 1135-1153 19 p.

Research output: Contribution to journalArticleResearchpeer-review