Research Output 1977 2019

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5 Citations (Scopus)

Transition-state analogues as inhibitors for GABA-aminotransferase

Iskander, M., Andrews, PR., Winkler, D., Brinkworth, RI., Di Paola, C., Cavell, S. & Issa, J., 1991, In : European Journal of Medicinal Chemistry. 26, 2, p. 129-135 7 p.

Research output: Contribution to journalArticleOther

2 Citations (Scopus)

Trimethylsilyl tag for probing protein–ligand interactions by NMR

Becker, W., Adams, L. A., Graham, B., Wagner, G. E., Zangger, K., Otting, G. & Nitsche, C., 1 Apr 2018, In : Journal of Biomolecular NMR. 70, 4, p. 211-218 8 p.

Research output: Contribution to journalArticleResearchpeer-review

44 Citations (Scopus)

Tripeptide motifs in biology: targets for peptidomimetic design

Ung, P. & Winkler, D., 2011, In : Journal of Medicinal Chemistry. 54, 5, p. 1111-1125 15 p.

Research output: Contribution to journalArticleResearchpeer-review

2 Citations (Scopus)

Truncated latrunculins as actin inhibitors targeting Plasmodium falciparum motility and host cell invasion

Johnson, S., Rahmani, R., Drew, D. R., Williams, M. J., Wilkinson, M. I., Tan, Y. H., Huang, J. X., Tonkin, C. J., Beeson, J., Baum, J., Smith, B. J. & Baell, J., 22 Dec 2016, In : Journal of Medicinal Chemistry. 59, 24, p. 10994-11005 12 p.

Research output: Contribution to journalArticleResearchpeer-review

7 Citations (Scopus)

Tumour targeting of Auger emitters using DNA ligands conjugated to octreotate

Lobachevsky, P. N., Smith, J., Denoyer, D., Skene, C. E., White, J. M., Flynn, B. L., Kerr, D. J., Hicks, R. & Martin, R. F., 2012, In : International Journal of Radiation Biology. 88, 12, p. 1009 - 1018 10 p.

Research output: Contribution to journalArticleResearchpeer-review

11 Citations (Scopus)

Two monoclonal antibodies to precisely the same epitope of type II collagen select non-crossreactive phage clones by phage display: implications for autoimmunity and molecular mimicry

Xu, Y., Ramsland, P. A., Davies, J. M., Scealy, M., Nandakumar, K. S., Holmdahl, R. & Rowley, M. J., 2004, In : Molecular Immunology. 41, 4, p. 411 - 419 9 p.

Research output: Contribution to journalArticleResearchpeer-review

26 Citations (Scopus)

Two-pronged attack: Dual inhibition of Plasmodium falciparum M1 and M17 metalloaminopeptidases by a novel series of hydroxamic acid-based inhibitors

Mistry, S. N., Drinkwater, N., Ruggeri, C., Kannan Sivaraman, K., Loganathan, S., Fletcher, S., Drag, M., Paiardini, A., Avery, V. M., Scammells, P. J. & McGowan, S., 2014, In : Journal of Medicinal Chemistry. 57, p. 9168 - 9183 16 p.

Research output: Contribution to journalArticleResearchpeer-review

29 Citations (Scopus)

Two-step iron(0)-mediated N-demethylation of N -methyl alkaloids

Kok, G. B. B., Pye, C. C., Singer, R. D. & Scammells, P. J., 2010, In : Journal of Organic Chemistry. 75, 14, p. 4806 - 4811 6 p.

Research output: Contribution to journalArticleResearchpeer-review

64 Citations (Scopus)

Ultrafast fabrication of covalently cross-linked multifunctional graphene oxide monoliths

Wan, W., Li, L., Zhao, Z., Hu, H., Hao, X., Winkler, D. A., Xi, L., Hughes, T. C. & Qiu, J., 2014, In : Advanced Functional Materials. 24, 31, p. 4915-4921 7 p.

Research output: Contribution to journalArticleResearchpeer-review

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68 Citations (Scopus)

Ultrahigh resolution drug design. II. Atomic resolution structures of human aldose reductase holoenzyme complexed with fidarestat and minalrestat; implications for the binding of cyclic imide inhibitors

El-Kabbani, O., Darmanin, C., Schneider, T. R., Hazemann, I., Ruiz, F., Oka, M., Joachimiak, A., Schulze-Briese, C., Tomizaki, T., Mitschler, A. & Podjarny, A. D., 2004, In : Proteins: Structure, Function, and Bioinformatics. 55, 4, p. 805 - 813 9 p.

Research output: Contribution to journalArticleResearchpeer-review

48 Citations (Scopus)

Understanding the roles of the "two QSARs"

Fujita, T. & Winkler, D. A., 2016, In : Journal of Chemical Information and Modeling. 56, 2, p. 269-274 6 p.

Research output: Contribution to journalArticleResearchpeer-review

1 Citation (Scopus)

Unlocking the full potential of lipid-based formulations using lipophilic salt/ionic liquid forms

Williams, H. D., Ford, L., Igonin, A., Shan, Z., Botti, P., Morgen, M. M., Hu, G., Pouton, C. W., Scammells, P. J., Porter, C. J. H. & Benameur, H., 2019, In : Advanced Drug Delivery Reviews. 142, 16 p.

Research output: Contribution to journalArticleResearchpeer-review

27 Citations (Scopus)

Unsaturated N-acetyl-D-glucosaminuronic acid glycosides as inhibitors of influenza virus sialidase

Mann, M. C., Islam, T., Dyason, J. C., Florio, P., Trower, C. J., Thomson, R. J. & Von Itzstein, M., 2006, In : Glycoconjugate Journal. 23, 1-2, p. 127 - 133 7 p.

Research output: Contribution to journalArticleResearchpeer-review

3 Citations (Scopus)

Unusual binding mode of the 2S4R stereoisomer of the potent aldose reductase cyclic imide inhibitor fidarestat (2S4S) in the 15 K crystal structure of the ternary complex refined at 0.78 A resolution: Implications for the inhibition mechanism

Zhao, H-T., Hazemann, I., Mitschler, A., Carbone, V., Joachimiak, A., Ginell, S. L., Podjarny, A. D. & El-Kabbani, O., 2008, In : Journal of Medicinal Chemistry. 51, 5, p. 1478 - 1481 4 p.

Research output: Contribution to journalArticleResearchpeer-review

59 Citations (Scopus)

Unzipping the role of chirality in nanoscale self-assembly of tripeptide hydrogels

Marchesan, S., Waddington, L., Easton, C. D., Winkler, D. A., Goodall, L., Forsythe, J. S. & Hartley, P. G., 2012, In : Nanoscale. 4, 21, p. 6752-6760 9 p.

Research output: Contribution to journalArticleResearchpeer-review

10 Citations (Scopus)

Up-regulation of carbonyl reductase 1 renders development of doxorubicin resistance in human gastrointestinal cancers

Matsunaga, T., Kezuka, C., Morikawa, Y., Suzuki, A., Endo, S., Iguchi, K., Miura, T., Nishinaka, T., Terada, T., El-Kabbani, O., Hara, A. & Ikari, A., 2015, In : Biological & Pharmaceutical Bulletin. 38, 9, p. 1309-1319 11 p.

Research output: Contribution to journalArticleResearchpeer-review

14 Citations (Scopus)

Use of Kv1.3 blockers for inflammatory skin conditions

Nguyen, W., Neale, D., Howard, B., Thompson, P., White, P., Wulff, H. & Manallack, D., 2010, In : Current Medicinal Chemistry. 17, 26, p. 2882 - 2896 15 p.

Research output: Contribution to journalArticleResearchpeer-review

13 Citations (Scopus)

Using active learning strategies to shift student attitudes and behaviours about learning and teaching in a research intensive educational context

White, P. J., Larson, I., Styles, K., Yuriev, E., Evans, D. R., Short, J. L., Rangachari, P. K., Malone, D. T., Davie, B., Naidu, S. & Eise, N., 2015, In : Pharmacy Education. 15, 1, p. 116-126 11 p.

Research output: Contribution to journalArticleResearchpeer-review

24 Citations (Scopus)

Using high throughput experimental data and in silico models to discover alternatives to toxic chromate corrosion inhibitors

Winkler, D. A., Breedon, M., White, P., Hughes, A. E., Sapper, E. D. & Cole, I., 2016, In : Corrosion Science. 106, p. 229-235 7 p.

Research output: Contribution to journalArticleResearchpeer-review

23 Citations (Scopus)

Using molecular dynamics to study liquid phase behavior: Simulations of the ternary sodium laurate/sodium oleate/water system

King, D., Warren, D., Pouton, C. & Chalmers, D., 2011, In : Langmuir: the ACS journal of surfaces and colloids. 27, 18, p. 11381 - 11393 13 p.

Research output: Contribution to journalArticleResearchpeer-review

6 Citations (Scopus)

Using the beta2-adrenoceptor for structure-based drug design

Manallack, D. T., Chalmers, D. K. & Yuriev, E., 2010, In : Journal of Chemical Education. 87, 6, p. 625 - 627 3 p.

Research output: Contribution to journalArticleResearchpeer-review

3 Citations (Scopus)

Utility of iron nanoparticles and a solution-phase iron species for the N-demethylation of alkaloids

Awalt, J. K., Lam, R., Kellam, B., Graham, B., Scammells, P. J. & Singer, R. D., 2017, In : Green Chemistry. 19, 11, p. 2587-2594 8 p.

Research output: Contribution to journalArticleResearchpeer-review

41 Citations (Scopus)

Validating Eaton's Hypothesis: Cubane as a Benzene Bioisostere

Chalmers, B. A., Xing, H., Houston, S., Clark, C., Ghassabian, S., Kuo, A., Cao, B., Reitsma, A., Murray, C-E. P., Stok, J. E., Boyle, G. M., Pierce, C. J., Littler, S. W., Winkler, D. A., Bernhardt, P. V., Pasay, C., De Voss, J. J., McCarthy, J., Parsons, P. G., Walter, G. H. & 6 others, Smith, M. T., Cooper, H. M., Nilsson, S. K., Tsanaktsidis, J., Savage, G. P. & Williams, C. M., 2016, In : Angewandte Chemie - International Edition. 55, 11, p. 3580-3585 6 p.

Research output: Contribution to journalArticleResearchpeer-review

9 Citations (Scopus)
21 Citations (Scopus)

Venom-derived peptide inhibitors of voltage-gated potassium channels

Norton, R. S. & Chandy, K. G., 2017, In : Neuropharmacology. 127, p. 124-138 15 p.

Research output: Contribution to journalArticleResearchpeer-review

Virtual Screening Against Carbohydrate-Binding Proteins: Evaluation and Application to Bacterial Burkholderia ambifaria Lectin

Dingjan, T., Gillon, É., Imberty, A., Pérez, S., Titz, A., Ramsland, P. A. & Yuriev, E., 24 Sep 2018, In : Journal of Chemical Information and Modeling. 58, 9, p. 1976-1989 14 p.

Research output: Contribution to journalArticleResearchpeer-review

14 Citations (Scopus)

Virtual screening using a conformationally flexible target protein: models for ligand binding to p38 alpha MAPK

Vinh, N., Simpson, J. S., Scammells, P. J. & Chalmers, D. K., 2012, In : Journal of Computer-Aided Molecular Design. 26, 4, p. 409 - 423 15 p.

Research output: Contribution to journalArticleResearchpeer-review

Visible light-triggered cargo release from donor acceptor Stenhouse adduct (DASA)-doped lyotropic liquid crystalline nanoparticles

Jia, S., Tan, A., Hawley, A., Graham, B. & Boyd, B. J., 15 Jul 2019, In : Journal of Colloid and Interface Science. 548, p. 151-159 9 p.

Research output: Contribution to journalArticleResearchpeer-review

37 Citations (Scopus)

VPS29 is not an active metallo-phosphatase but is a rigid scaffold required for retromer interaction with accessory proteins

Swarbrick, J., Shaw, D., Chhabra, S., Ghai, R., Valkov, E., Norwood, S., Seaman, M. & Collins, B., 2011, In : PLoS ONE. 6, 5, 15 p., e20420.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Water-soluble organic compounds in biomass burning aerosols over Amazonia 1. Characterization by NMR abd GC-MS

Graham, B., Mayol-Bracero, O. L., Guyon, P., Roberts, G. C., Decesari, S., Facchini, M. C., Artaxo, P., Maenhaut, W., Koll, P. & Andreae, M. O., 2002, In : Journal of Geophysical Research. 107, D20, p. LB14.1 - LB14.16 16 p.

Research output: Contribution to journalArticleResearchpeer-review

Water-soluble organic compounds in biomass burning aerosols over Amazonia 2. Apportionment of the chemical composition and importance of the polyacidic fraction

Mayol-Bracero, O. L., Guyon, P., Graham, B. & Andreae, M. O., 2002, In : Journal of Geophysical Research. 107, D20, p. LBA59.1 - LBA59.15 15 p.

Research output: Contribution to journalArticleResearchpeer-review

30 Citations (Scopus)

XH-14 analogues as adenosine antagonists

Scammells, P. J., Baker, S. P. & Beauglehole, A. R., 1 Sep 1998, In : Bioorganic and Medicinal Chemistry. 6, 9, p. 1517-1524 8 p.

Research output: Contribution to journalArticleResearchpeer-review

5 Citations (Scopus)

X-ray crystal structure of plasmin with tranexamic acid–derived active site inhibitors

Law, R. H. P., Wu, G., Leung, E. W. W., Hidaka, K., Quek, A. J., Caradoc-Davies, T. T., Jeevarajah, D., Conroy, P. J., Kirby, N. M., Norton, R. S., Tsuda, Y. & Whisstock, J. C., 9 May 2017, In : Blood Advances. 1, 12, p. 766-771 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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4 Citations (Scopus)

Zinc is not required for activity of TPO agonists acting at the c-Mpl receptor transmembrane domain

Andrade, J., Cablewski, T., Condie, G., Haylock, D. N., Meagher, L., Riches, A. G., Tarasova, A., Werkmeister, J. A., White, J. & Winkler, D. A., 2010, In : ACS Chemical Biology. 5, 8, p. 741-745 5 p.

Research output: Contribution to journalArticleResearchpeer-review

209 Citations (Scopus)

Zwitterionic-coated "stealth" nanoparticles for biomedical applications: Recent advances in countering biomolecular corona formation and uptake by the mononuclear phagocyte system

Pombo-Garcia, K., Zarschler, K., Barbaro, L., Barreto Solano, J. A., O'Malley, W. I., Spiccia, L., Stephan, H. & Graham, B., 2014, In : Small. 10, 13, p. 2516 - 2529 14 p.

Research output: Contribution to journalArticleResearchpeer-review

8 Citations (Scopus)

Zwitterionic modification of ultrasmall iron oxide nanoparticles for reduced protein corona formation

Pombo-García, K., Rühl, C. L., Lam, R., Barreto, J. A., Ang, C-S., Scammells, P. J., Comba, P., Spiccia, L., Graham, B., Joshi, T. & Stephan, H., 2017, In : ChemPlusChem. 82, 4, p. 638–646 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Zwitterionic polymer-coated ultrasmall superparamagnetic iron oxide nanoparticles with low protein interaction and high biocompatibility

Pombo-García, K., Weiss, S., Zarschler, K., Ang, C-S., Hübner, R., Pufe, J., Meister, S., Seidel, J., Pietzsch, J., Spiccia, L., Stephan, H. & Graham, B., 2016, In : ChemNanoMat. 2, 10, p. 959-971 13 p.

Research output: Contribution to journalArticleResearchpeer-review

9 Citations (Scopus)

Δ-Myrtoxin-Mp1a is a Helical Heterodimer from the Venom of the Jack Jumper Ant that has Antimicrobial, Membrane-Disrupting, and Nociceptive Activities

Dekan, Z., Headey, S. J., Scanlon, M., Baldo, B. A., Lee, T-H., Aguilar, M-I., Deuis, J. R., Vetter, I., Elliott, A. G., Amado, M., Cooper, M. A., Alewood, D. & Alewood, P. F., 2017, In : Angewandte Chemie - International Edition. 56, 29, p. 8495-8499 6 p.

Research output: Contribution to journalArticleResearchpeer-review