Research Output 1977 2019

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Article
2000

British Journal of Pharmacology

Baker, S. P., Scammells, P. J. & Belardinelli, L., 2000, In : British Journal of Pharmacology. 130, 5, p. 1156 - 1164 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Crystallization and preliminary x-ray analysis of porcine aldehyde reductase in complex with coenzyme and quercetin

El-Kabbani, O. & Chung, R. P-T., 2000, In : Protein and Peptide Letters. p. 201 - 206 6 p.

Research output: Contribution to journalArticleResearchpeer-review

25 Citations (Scopus)

Differential A1-adenosine receptor reserve for inhibition of cyclic AMB accumulation and G-protein activation in DDT1MF-2 cells

Baker, S. P., Scammells, P. J., Belardinelli, L. & Belardinelli, L., 1 Jan 2000, In : British Journal of Pharmacology. 130, 5, p. 1156-1164 9 p.

Research output: Contribution to journalArticleResearchpeer-review

20 Citations (Scopus)

Expression, characterization and structure determination of an active site mutant (Glu202-Gln) of mini-stromelysin-1

Steele, D. L., El-Kabbani, O., Dunten, P., Windsor, L. J. J., Kammlott, R. U. U., Crowther, R. L., Michoud, C., Engler, J. A. & Birktoft, J. J., 2000, In : Protein Engineering. p. 397 - 405 9 p.

Research output: Contribution to journalArticleResearchpeer-review

17 Citations (Scopus)

Identification of initiation sites for T4 lysozyme folding using CD and NMR spectroscopy of peptide fragments

Najbar, L. N., Craik, D. J., Wade, J. D. & McLeish, M. J., 2000, In : Biochemistry. p. 5911 - 5920 10 p.

Research output: Contribution to journalArticleResearchpeer-review

25 Citations (Scopus)

Modelling studies on the binding of substrate and inhibitor to the active site of human sorbitol dehydrogenase

Darmanin, C. & El-Kabbani, O., 2000, In : Bioorganic and Medicinal Chemistry Letters. p. 1101 - 1104 4 p.

Research output: Contribution to journalArticleResearchpeer-review

35 Citations (Scopus)

Mycalamides C and D, Cytotoxic Compounds from the Marine Sponge Stylinos n. species

Simpson, J. S., Garson, M. J., Blunt, J. W., Munro, M. H. G. & Hooper, J. N. A., 2000, In : Journal of Natural Products. 63, p. 704 - 706 3 p.

Research output: Contribution to journalArticleResearchpeer-review

7 Citations (Scopus)

N-Piperonyl analogue of the atypical antipsychotic clozapine

Capuano, B., Crosby, I. T., Gable, R. W. & Lloyd, E. J., 1 Jan 2000, In : Acta Crystallographica Section C: Crystal Structure Communications. 56, 3, p. 339-340 2 p.

Research output: Contribution to journalArticleResearchpeer-review

10 Citations (Scopus)

Preliminary 1H NMR investigation of sialic acid transfer by the trans-sialidase from Trypanosoma cruzi

Wilson, J. C., Kiefel, M. J., Abo, S. & Von Itzstein, M., 2000, In : Bioorganic and Medicinal Chemistry Letters. p. 2791 - 2794 4 p.

Research output: Contribution to journalArticleResearchpeer-review

29 Citations (Scopus)

Production of an enterotoxin by a gastro-enteritis-associated Aeromonas strain

Trower, C. J., Abo, S., Majeed, K. & Von Itzstein, M., 2000, In : Journal of Medical Microbiology. p. 121 - 126 6 p.

Research output: Contribution to journalArticleResearchpeer-review

16 Citations (Scopus)

Rapid access to uronic acid-based mimetics of Kdn2en from D-glucurono-6,3-lactone

Florio, P., Thomson, R. J. & Von Itzstein, M., 2000, In : Carbohydrate Research. p. 445 - 448 4 p.

Research output: Contribution to journalArticleResearchpeer-review

10 Citations (Scopus)

RNA-Protein Crosslinking to AMP Residues at Internal Positions in RNA with a New Photocrosslinking ATP Analog

Costas, C., Yuriev, E., Meyer, K. L., Guion, S. & Hanna, M. M., 2000, In : Nucleic Acids Research. 28, 9, p. 1849 - 1858 10 p.

Research output: Contribution to journalArticleResearchpeer-review

20 Citations (Scopus)

Synthesis and evaluation of C-9 modified N-acetylneuraminic acid derivatives as substrates for N-acetylneuraminic acid aldolase

Kiefel, M. J., Wilson, J. C., Bennett, S., Gredley, M. & Von Itzstein, M., 2000, In : Bioorganic & Medicinal Chemistry. p. 657 - 664 8 p.

Research output: Contribution to journalArticleResearchpeer-review

8 Citations (Scopus)

The conformational and biological analysis of a cyclic anti-obesity peptide from the C-terminal domain of human growth hormone

Ogru, E., Wilson, J. C., Heffernan, M., Jiang, W., Chalmers, D. K., Libinaki, R. & Ng, F. M., 2000, In : Journal of Peptide Research. p. 388 - 397 10 p.

Research output: Contribution to journalArticleResearchpeer-review

25 Citations (Scopus)

The design, synthesis and biological evaluation of neuraminic acid-based probes of Vibrio cholerae sialidase

Wilson, J. C., Thomson, R. J., Dyason, J. C., Florio, P., Quelch, K., Abo, S. & Von Itzstein, M., 2000, In : Tetrahedron-Asymmetry. p. 53 - 73 21 p.

Research output: Contribution to journalArticleResearchpeer-review

3 Citations (Scopus)

The identification of a potent imidazoline-based vascular K ATP channel antagonist

Bell, K. L., Favaloro, J. L., Khalil, V., Iskander, M. N. & McPherson, G. A., 2000, In : Naunyn-Schmiedeberg's Archives of Pharmacology. p. 145 - 151 7 p.

Research output: Contribution to journalArticleResearchpeer-review

7 Citations (Scopus)

The synthesis of biotinylated carbohydrates as probes for carbohydrate-recognizing proteins

Angus, D. I., Kiefel, M. J. & Von Itzstein, M., 2000, In : Bioorganic & Medicinal Chemistry. p. 2709 - 2718 10 p.

Research output: Contribution to journalArticleResearchpeer-review

47 Citations (Scopus)

The three-dimensional structure of the Nudix enzyme diadenosine tetraphosphate hydrolase from Lupinus angustifolius L

Swarbrick, J. D., Bashtannyk, T., Maksel, D., Zhang, X. R., Blackburn, G. M., Gayler, K. R. & Gooley, P., 2000, In : Journal of Molecular Biology. 302, 5, p. 1165 - 1177 13 p.

Research output: Contribution to journalArticleResearchpeer-review

1999
4 Citations (Scopus)

8-Chloro-11-[4-(8-chloro-5H-dibenzo[b,e][1,4]diazepin-11-yl)piperazino]-5H- dibenzo[b,e][1,4]diazepine

Capuano, B., 1999, In : Molecules. 4, 11, p. 329-332 4 p.

Research output: Contribution to journalArticleResearchpeer-review

10 Citations (Scopus)

Adenosine receptor ligands with oxygenated N6-substituents

Hutchinson, S. A., Baker, S. P. & Scammells, P. J., 5 Apr 1999, In : Bioorganic and Medicinal Chemistry Letters. 9, 7, p. 933-936 4 p.

Research output: Contribution to journalArticleResearchpeer-review

A facile synthesis of Neu5Ac2enderivative from the glycosides of N - acetylneureminic acid

Kok, G. B., Groves, D. R. & Von Itzstein, M., 1999, In : Journal of the Chemical Society, Perkin Transactions 1. p. 2109 - 2115 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Aldose and aldehyde reductases: Structure-function studies on the coenzyme and inhibitor-binding sites

El-Kabbani, O., Old, S. E., Ginell, S. L. & Carper, D. A., 1999, In : Molecular Vision. p. 20 - 25 6 p.

Research output: Contribution to journalArticleResearchpeer-review

How pure is your thiosaloside? A reinvestigation into the HPLC purification of thioglycosides of N-acetylneuraminic acid

Groves, D. R., Bradley, S. J., Rose, F. J., Kiefel, M. J. & Von Itzstein, M., 1999, In : Glycoconjugate Journal. p. 13 - 17 5 p.

Research output: Contribution to journalArticleResearchpeer-review

12 Citations (Scopus)

Investigation of 5 - HT4 agonist activities using molecular field analysis

Iskander, M. N., Coupar, I. M. & Winkler, D. A., 1999, In : Journal of the Chemical Society. Perkin Transactions 2. p. 153 - 158 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Investigation of 5-HT 4 agonist activities using molecular field analysis

Iskander, M., Coupar, I. & Winkler, D. A., 1999, In : Journal of the Chemical Society, Perkin Transactions 2. 2, p. 153-158 6 p.

Research output: Contribution to journalArticleResearchpeer-review

66 Citations (Scopus)

Investigation of the stability of thiosialosides towards hydrolysis by sialidases using NMR spectroscopy

Wilson, J. C., Kiefel, M. J., Angus, D. I. & Von Itzstein, M., 1999, In : Organic Letters. p. 443 - 446 4 p.

Research output: Contribution to journalArticleResearchpeer-review

45 Citations (Scopus)

New insights into the Berg-Holm oxomolybdoenzyme model

Doonan, C. J., Slizys, D. & Young, C. G., 1999, In : Journal of the American Chemical Society. p. 6430 - 6436 7 p.

Research output: Contribution to journalArticleResearchpeer-review

29 Citations (Scopus)

Structural analysis of the heparin-binding site of the NC1 domain of collagen XIV by CD and NMR

Montserret, R., Aubert-Foucher, E., McLeish, M. J., Hill, J. M., Ficheux, D., Jaquinod, M., Van Der Rest, M., Deleage, G. & Penin, F., 1999, In : Biochemistry. p. 6479 - 6488 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Synthesis and serotonergic activity of 2-oxadiazalyl-5-substituted -N,N-dimethyltriptamines novel antagonist for the vascular 5-HT1b -like receptor

Moloney, G. P., Martin, G. R., Mathews, N., Maclennan, S., Dodsworth, S., Sang, P. Y., Knight, C., Maxwell, M. & Glen, R., 1999, In : Journal of the Chemical Society, Perkin Transactions 1. p. 2725 - 2733 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Synthesis and serotonergic activity of a series of 2-(N-benzyl)-carboxamid - 5 - substituted-N,N- dimethyltriptamine derivative: novel antagonists for the vascular5-HT1b- like receptors

Moloney, G. P., Martin, G. R., Mathews, N., Hobbs, H., Dodsworth, S., Sang, P. Y., Knight, C., Maxwell, M. & Glen, R., 1999, In : Journal of the Chemical Society, Perkin Transactions 1. p. 2699 - 2711 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Synthesis and serotonergic activity of substituted 2,N- benzylcarboxamido - 5 -(2-ethyl-1-dioxoimidazolidinyl)-N,N-dimethyltryptamin derivative: Novel antagonists for the vascular5 -HT 1b - like receptor

Moloney, G. P., Martin, G. R., Mathews, N., Milne, A., Hobbs, H., Dodsworth, S., Sang, P. Y., Knight, C., Williams, M., Maxwell, M. & Glen, R., 1999, In : Journal of Medicinal Chemistry. p. 2504 - 2526 23 p.

Research output: Contribution to journalArticleResearchpeer-review

41 Citations (Scopus)

Synthesis of 2-substituted 3-acylbenzo[b]furans via the palladium catalysed carbonylative cyclisation of ortho-hydroxytolans

Lütjens, H. & Scammells, P. J., 1 Jan 1999, In : Synlett. 7, p. 1079-1081 3 p.

Research output: Contribution to journalArticleResearchpeer-review

25 Citations (Scopus)

Synthesis of carbohydrates with an anomeric thiol moiety for elaboration into metabolically stable thioglycosides

Kiefel, M. J., Thomson, R. J., Radovanovic, M. & Von Itzstein, M., 1999, In : Journal of Carbohydrate Chemistry. p. 937 - 959 23 p.

Research output: Contribution to journalArticleResearchpeer-review

Synthesis of D-b-D - glucopyranosiduronic acids as mimetrics of 2,3- unsaturated sialic acids for sialidase inhibition

Florio, P., Thomson, R. J., Abo, S. & Von Itzstein, M., 1999, In : Bioorganic and Medicinal Chemistry Letters. p. 2065 - 2068 4 p.

Research output: Contribution to journalArticleResearchpeer-review

Synthesized and pharmacological profile of a series of 2,5-substituted-N,N -dimethyl ptamine derivative as novel antagonists for the vascular 5-HT1b - like receptor

Moloney, G. P., Martin, G. R., Mathews, N., Hobbs, H., Dodsworth, S., Sang, P. Y., Knight, C., Maxwell, M. & Glen, R. C., 1999, In : Journal of the Chemical Society, Perkin Transactions 1. p. 2713 - 2723 11 p.

Research output: Contribution to journalArticleResearchpeer-review

12 Citations (Scopus)

The synthesis and evaluation of novel sialic acid analogues bound to matrices for the purification of sialic acid-recognising proteins

Abo, S., Ciccotosto, S., Alafaci, A. & Von Itzstein, M., 1999, In : Carbohydrate Research. p. 201 - 208 8 p.

Research output: Contribution to journalArticleResearchpeer-review

1998
135 Citations (Scopus)

Cleavage and activation of proteinase-activated receptor-2 on human neutrophils by gingipain-R from Porphyromonas gingivalis

Lourbakos, A., Chinni, C., Thompson, P., Potempa, J., Travis, J., MacKie, E. J. & Pike, R. N., 11 Sep 1998, In : FEBS Letters. 435, 1, p. 45-48 4 p.

Research output: Contribution to journalArticleResearchpeer-review

Crystal structure of 4-(3′-acetoxypropyl)-6-bromo-2-methoxyphenol, C12H15BrO4

Hutchinson, S. A., Scammells, P. J. & Tiekink, E. R. T., 1 Apr 1998, In : Zeitschfrift fur Kristallographie. 213, 1-4, p. 57-58 2 p.

Research output: Contribution to journalArticleResearchpeer-review

1 Citation (Scopus)

Crystal structure of 5-(3′-acetoxypropyl)-4-iodo-7-methoxy-2-phenyl-ben-zo[b]furan, C20H19IO4

Scammells, P. J. & Tiekink, E. R. T., 1 Apr 1998, In : Zeitschfrift fur Kristallographie. 213, 1-4, p. 59-60 2 p.

Research output: Contribution to journalArticleResearchpeer-review

13 Citations (Scopus)

Lanasol dyes and wool fibres. Part I: Model studies on the mechanism of dye fixation in a mixed solvent system

Church, J. S., Davie, A. S., Scammells, P. J. & Tucker, D. J., 1 Dec 1998, In : Dyes and Pigments. 39, 4, p. 291-312 22 p.

Research output: Contribution to journalArticleResearchpeer-review

5 Citations (Scopus)

Lanasol dyes and wool fibres. part II: Model studies on the mechanism of dye fixation in an aqueous system

Church, J. S., Davie, A. S., Scammells, P. J. & Tucker, D. J., 1 Dec 1998, In : Dyes and Pigments. 39, 4, p. 313-333 21 p.

Research output: Contribution to journalArticleResearchpeer-review

5 Citations (Scopus)

N6-(5,6-epoxynorbornyl)adenosine analogs as A1adenosine agonists

Wright, D. M. J., Baker, S. P., Stewart, S. G. & Scammells, P. J., 15 Dec 1998, In : Bioorganic and Medicinal Chemistry Letters. 8, 24, p. 3647-3648 2 p.

Research output: Contribution to journalArticleResearchpeer-review

50 Citations (Scopus)

Synthesis of natural products possessing a benzo[b]furan skeleton

Lütjens, H. & Scammells, P. J., 3 Sep 1998, In : Tetrahedron Letters. 39, 36, p. 6581-6584 4 p.

Research output: Contribution to journalArticleResearchpeer-review

30 Citations (Scopus)

XH-14 analogues as adenosine antagonists

Scammells, P. J., Baker, S. P. & Beauglehole, A. R., 1 Sep 1998, In : Bioorganic and Medicinal Chemistry. 6, 9, p. 1517-1524 8 p.

Research output: Contribution to journalArticleResearchpeer-review

1997
24 Citations (Scopus)

A new synthesis of the benzofuran adenosine antagonist XH-14

Hutchinson, S. A., Luetjens, H. & Scammells, P. J., 16 Dec 1997, In : Bioorganic and Medicinal Chemistry Letters. 7, 24, p. 3081-3084 4 p.

Research output: Contribution to journalArticleResearchpeer-review

49 Citations (Scopus)

Coordination modes of a series of xylylene-bridged bis(l,4,7-triazacyclonon-l-yl) ligands: Synthesis, structure, and properties of nickel(II) and copper(II) complexes

Graham, B., Fallon, G. D., Hearn, M. T. W., Hockless, D. C. R., Lazarev, G. & Spiccia, L., 1997, In : Inorganic Chemistry. 36, 27, p. 6366-6373 8 p.

Research output: Contribution to journalArticleResearchpeer-review

30 Citations (Scopus)

Purification and characterization of basic proteins with in vitro antifungal activity from seeds of cotton, Gossypium hirsutum

Chung, R. P. T., Neumann, G. M. & Polya, G. M., 27 Aug 1997, In : Plant Science. 127, 1, p. 1-16 16 p.

Research output: Contribution to journalArticleResearchpeer-review

Towards synthetic models for trinuclear copper active sites of ascorbate oxidase and laccase: self-assembly, crystal structure and magnetic properties of the copper(II) complexes of 1,3,5-tris(1,4,7-triazacyclonon-1-ylmethyl)benzene

Spiccia, L., Graham, B., Hearn, M. T. W., Lazarev, G., Moubaraki, B., Murray, K. S. & Tiekink, E. R. T., 1997, In : Dalton Transactions. p. 4089 - 4097 9 p.

Research output: Contribution to journalArticleResearchpeer-review

1996
24 Citations (Scopus)

A novel irreversible antagonist of the A1-adenosine receptor

Srinivas, M., Shryock, J. C., Scammells, P. J., Ruble, J., Baker, S. P., Belardinelli, L., Belardinelli, L. & Belardinelli, L., 1 Jul 1996, In : Molecular Pharmacology. 50, 1, p. 196-205 10 p.

Research output: Contribution to journalArticleResearchpeer-review

54 Citations (Scopus)

Modulation of the function of human MDR1 P-glycoprotein by the antimalarial drug mefloquine

Riffkin, C. D., Chung, R., Wall, D. M., Zalcberg, J. R., Cowman, A. F., Foley, M. & Tilley, L., 22 Nov 1996, In : Biochemical Pharmacology. 52, 10, p. 1545-1552 8 p.

Research output: Contribution to journalArticleResearchpeer-review