Research Output 1977 2019

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2017

Characterisation of a novel coumarin-based fluorescent probe for monitoring nitric oxide production in macrophages

Sadek, M., Barzegar Amiri Olia, M., Nowell, C. J., Barlow, N., Schiesser, C. H., Nicholson, S. E. & Norton, R. S., 15 Oct 2017, In : Bioorganic & Medicinal Chemistry. 25, 20, p. 5743–5748 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Characterization of the Polymyxin D Synthetase Biosynthetic Cluster and Product Profile of Paenibacillus polymyxa ATCC 10401

Galea, C. A., Han, M., Zhu, Y., Roberts, K., Wang, J., Thompson, P. E., Li, J. & Velkov, T., 26 May 2017, In : Journal of Natural Products. 80, 5, p. 1264-1274 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Chemical Tagging with tert-Butyl and Trimethylsilyl Groups for Measuring Intermolecular Nuclear Overhauser Effects in a Large Protein–Ligand Complex

Jabar, S., Adams, L. A., Wang, Y., Aurelio, L., Graham, B. & Otting, G., 21 Sep 2017, In : Chemistry - A European Journal. 23, 53, p. 13033-13036 4 p.

Research output: Contribution to journalArticleResearchpeer-review

Class II phosphoinositide 3-kinases as novel drug targets

Falasca, M., Hamilton, J. R., Selvadurai, M. V., Sundaram, K., Adamska, A. & Thompson, P., 12 Jan 2017, In : Journal of Medicinal Chemistry. 60, 1, p. 47-65 19 p.

Research output: Contribution to journalArticleResearchpeer-review

Competitive Inhibition Mechanism of Acetylcholinesterase without Catalytic Active Site Interaction: Study on Functionalized C60 Nanoparticles via in Vitro and in Silico Assays

Liu, Y., Yan, B., Winkler, D. A., Fu, J. & Zhang, A., 7 Jun 2017, In : ACS Applied Materials and Interfaces. 9, 22, p. 18626-18638 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Computational Models of the Gastrointestinal Environment. 1. The Effect of Digestion on the Phase Behavior of Intestinal Fluids

Birru, W. A., Warren, D., Headey, S. J., Benameur, H., Porter, C., Pouton, C. W. & Chalmers, D. K., 6 Mar 2017, In : Molecular Pharmaceutics. 14, 3, p. 566-579 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Computational Models of the Intestinal Environment. 3. The Impact of Cholesterol Content and pH on Mixed Micelle Colloids

Suys, E. J. A., Warren, D. B., Porter, C. J. H., Benameur, H., Pouton, C. W. & Chalmers, D. K., 6 Nov 2017, In : Molecular Pharmaceutics. 14, 11, p. 3684-3697 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Design and evaluation of novel polymyxin fluorescent probes

Yun, B., Roberts, K. D., Thompson, P. E., Nation, R. L., Velkov, T. & Li, J., 11 Nov 2017, In : Sensors. 17, 11, 8 p., 2598.

Research output: Contribution to journalArticleResearchpeer-review

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Distribution and kinetics of the Kv1.3-blocking peptide HsTX1[R14A] in experimental rats

Bergmann, R., Kubeil, M., Zarschler, K., Chhabra, S., Tajhya, R. B., Beeton, C., Pennington, M. W., Bachmann, M. H., Norton, R. S. & Stephan, H., 1 Dec 2017, In : Scientific Reports. 7, 1, 11 p., 3756.

Research output: Contribution to journalArticleResearchpeer-review

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Double-Arm Lanthanide Tags Deliver Narrow Gd3+–Gd3+ Distance Distributions in Double Electron–Electron Resonance (DEER) Measurements

Welegedara, A. P., Yang, Y., Lee, M. D., Swarbrick, J. D., Huber, T., Graham, B., Goldfarb, D. & Otting, G., 25 Aug 2017, In : Chemistry - A European Journal. 23, 48, p. 11694-11702 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Drug discovery beyond the rule of 5 - opportunities and challenges

Doak, B. C. & Kihlberg, J., 2017, In : Expert Opinion on Drug Discovery. 12, 2, p. 115-119 5 p.

Research output: Contribution to journalArticleResearchpeer-review

Effects of guanidino modified aminoglycosides on mammalian membranes studied using a quartz crystal microbalance

John, T., Voo, Z. X., Kubeil, C., Abel, B., Graham, B., Spiccia, L. & Martin, L. L., 2017, In : MedChemComm. 8, 5, p. 1112-1120 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Endosomal NOX2 oxidase exacerbates virus pathogenicity and is a target for antiviral therapy

To, E. E., Vlahos, R., Luong, R., Halls, M. L., Reading, P. C., King, P. T., Chan, C., Drummond, G. R., Sobey, C. G., Broughton, B. R. S., Starkey, M. R., van der Sluis, R., Lewin, S. R., Bozinovski, S., O'Neill, L. A. J., Quach, T., Porter, C. J. H., Brooks, D. A., O'Leary, J. & Selemidis, S., 1 Dec 2017, In : Nature Communications. 8, 1, 17 p., 69.

Research output: Contribution to journalArticleResearchpeer-review

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Endosomal signaling of the receptor for calcitonin gene-related peptide mediates pain transmission

Yarwood, R. E., Imlach, W. L., Lieu, T., Veldhuis, N. A., Jensen, D. D., Herenbrink, C. K., Aurelio, L., Cai, Z., Christie, M. J., Poole, D. P., Porter, C. J. H., McLean, P., Hicks, G. A., Geppetti, P., Halls, M. L., Canals, M. & Bunnett, N. W., 14 Nov 2017, In : Proceedings of the National Academy of Sciences of the United States of America. 114, 46, p. 12309-12314 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Extending the Excitation Wavelength of Potential Photosensitizers via Appendage of a Kinetically Stable Terbium(III) Macrocyclic Complex for Applications in Photodynamic Therapy

Ung, P., Clerc, M., Huang, H., Qiu, K., Chao, H., Seitz, M., Boyd, B. J., Graham, B. & Gasser, G., 17 Jul 2017, In : Inorganic Chemistry. 56, 14, p. 7960-7974 15 p.

Research output: Contribution to journalArticleResearchpeer-review

Fluorescent diphenylphosphonate-based probes for detection of serine protease activity during inflammation

Edgington-Mitchell, L. E., Barlow, N., Aurelio, L., Samha, A., Szabo, M., Graham, B. & Bunnett, N., 15 Jan 2017, In : Bioorganic and Medicinal Chemistry Letters. 27, 2, p. 254-260 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Fragment library screening identifies hits that bind to the non-catalytic surface of Pseudomonas aeruginosa DsbA1

Mohanty, B., Rimmer, K., McMahon, R. M., Headey, S. J., Vazirani, M., Shouldice, S. R., Coinçon, M., Tay, S., Morton, C. J., Simpson, J. S., Martin, J. L. & Scanlon, M. J., 1 Mar 2017, In : PLoS ONE. 12, 3, 20 p., e0173436.

Research output: Contribution to journalArticleResearchpeer-review

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Functional characterization of the unique terminal thioesterase domain from polymyxin synthetase

Galea, C., Roberts, K. D., Zhu, Y., Thompson, P. E., Li, J. & Velkov, T., 31 Jan 2017, In : Biochemistry. 56, 4, p. 657-668 12 p.

Research output: Contribution to journalArticleResearchpeer-review

HN, N, Cα and Cβ assignments of the two periplasmic domains of Neisseria meningitidis DsbD

Smith, R. P., Mohanty, B., Williams, M. L., Scanlon, M. J. & Heras, B., 1 Oct 2017, In : Biomolecular NMR Assignments. 11, 2, p. 181–186 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Hormone-like peptides in the venoms of marine cone snails

Robinson, S. D., Li, Q., Bandyopadhyay, P. K., Gajewiak, J., Yandell, M., Papenfuss, A. T., Purcell, A., Norton, R. S. & Safavi-Hemami, H., 1 Apr 2017, In : General and Comparative Endocrinology. 244, p. 11-18 8 p.

Research output: Contribution to journalArticleResearchpeer-review

How kanamycin A interacts with bacterial and mammalian mimetic membranes

John, T., Thomas, T., Abel, B., Wood, B. R., Chalmers, D. K. & Martin, L. L., 1 Nov 2017, In : Biochimica et Biophysica Acta - Biomembranes. 1859, 11, p. 2242-2252 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Inhibition of DYRK1A disrupts neural lineage specificationin human pluripotent stem cells

Bellmaine, S. F., Ovchinnikov, D. A., Manallack, D. T., Cuddy, C. E., Elefanty, A. G., Stanley, E. G., Wolvetang, E. J., Williams, S. J. & Pera, M., 8 Sep 2017, In : eLife. 6, 20 p., e24502.

Research output: Contribution to journalArticleResearchpeer-review

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Investigation of donor-acceptor Stenhouse adducts as new visible wavelength-responsive switching elements for lipid-based liquid crystalline systems

Jia, S., Du, J. D., Hawley, A., Fong, W-K., Graham, B. & Boyd, B. J., 7 Mar 2017, In : Langmuir: the ACS journal of surfaces and colloids. 33, 9, p. 2215-2221 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Ionic Liquid Forms of Weakly Acidic Drugs in Oral Lipid Formulations: Preparation, Characterization, in Vitro Digestion, and in Vivo Absorption Studies

Sahbaz, Y., Nguyen, T. H., Ford, L., McEvoy, C. L., Williams, H. D., Scammells, P. J. & Porter, C. J. H., 6 Nov 2017, In : Molecular Pharmaceutics. 14, 11, p. 3669-3683 15 p.

Research output: Contribution to journalArticleResearchpeer-review

Isoform-specific biased agonism of histamine H3 receptor agonists

Riddy, D. M., Cook, A. E., Diepenhorst, N. A., Bosnyak, S., Brady, R., La Cour, C. M., Mocaer, E., Summers, R. J., Charman, W. N., Sexton, P. M., Christopoulos, A. & Langmead, C. J., 1 Feb 2017, In : Molecular Pharmacology. 91, 2, p. 87-99 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Linear and Angular Heteroacenes from Double-Electrophilic Cyclization (DEC) and DEC-Reductive Elimination of Diynes

Gupta, A. & Flynn, B. L., 21 Apr 2017, In : Organic Letters. 19, 8, p. 1939-1941 3 p.

Research output: Contribution to journalArticleResearchpeer-review

Lipid interactions modulate the structural and antigenic properties of the C-terminal domain of the malaria antigen merozoite surface protein 2

Das, S. C., Morales, R. A. V., Seow, J., Krishnarjuna, B., Dissanayake, R., Anders, R. F., Macraild, C. A. & Norton, R. S., 2017, In : FEBS Journal. 284, 16, p. 649–2662 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Materials genome in action: identifying the performance limits of physical hydrogen storage

Thornton, A. W., M. Simon, C., Kim, J., Kwon, O., S. Deeg, K., Konstas, K., Pas, S. J., Hill, M. R., Winkler, D. A., Haranczyk, M. & Smit, B., Apr 2017, In : Chemistry of Materials. 29, 7, p. 2844-2854 11 p.

Research output: Contribution to journalArticleResearchpeer-review

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Mechanisms of Carbonyl Activation by BINOL N-Triflylphosphoramides: Enantioselective Nazarov Cyclizations

Lovie-Toon, J. P., Tram, C. M., Flynn, B. L. & Krenske, E. H., 5 May 2017, In : ACS Catalysis. 7, 5, p. 3466-3476 11 p.

Research output: Contribution to journalArticleResearchpeer-review

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Modulating the activity of membrane-active peptides through Zn(II) complexation

Paquet-Côté, P. A., Tuck, K. L., Paradis, J. P., Graham, B. & Voyer, N., 13 Dec 2017, In : Tetrahedron Letters. 58, 50, p. 4672-4676 5 p.

Research output: Contribution to journalArticleResearchpeer-review

Molecular insights into the interaction between the SPRY domain-containing SOCS box protein SPSB2 and peptides based on the binding motif from iNOS

Leung, E., Mulcair, M., Yap, S., Nicholson, S. E., Scanlon, M. & Norton, R., 2017, In : Australian Journal of Chemistry. 70, 2, p. 191-200 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Molecular simulations of carbohydrates with a fucose-binding Burkholderia ambifaria lectin suggest modulation by surface residues outside the fucose-binding pocket

Dingjan, T., Imberty, A., Pérez, S., Yuriev, E. & Ramsland, P. A., 21 Jun 2017, In : Frontiers in Pharmacology. 8, JUN, 393.

Research output: Contribution to journalArticleResearchpeer-review

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Multistereocenter-Containing Cyclopentanoids from Ynamides via Oxazolidinone-Controlled Nazarov Cyclization

Manchala, N., Law, H. Y. L., Kerr, D. J., Volpe, R., Lepage, R. J., White, J. M., Krenske, E. H. & Flynn, B. L., 7 Jul 2017, In : Journal of Organic Chemistry. 82, 13, p. 6511-6527 17 p.

Research output: Contribution to journalArticleResearchpeer-review

Neurokinin 1 receptor signaling in endosomes mediates sustained nociception and is a viable therapeutic target for prolonged pain relief

Jensen, D. D., Lieu, T., Halls, M. L., Veldhuis, N. A., Imlach, W. L., Mai, Q. N., Poole, D. P., Quach, T., Aurelio, L., Conner, J., Klein Herenbrink, C., Barlow, N., Simpson, J. S., Scanlon, M. J., Graham, B., McCluskey, A., Robinson, P. J., Escriou, V., Nassini, R., Materazzi, S. & 6 othersGeppetti, P., Hicks, G. A., Christie, M. J., Porter, C. J. H., Canals, M. & Bunnett, N. W., 31 May 2017, In : Science Translational Medicine. 9, 392, 15 p., aal3447.

Research output: Contribution to journalArticleResearchpeer-review

New lanthanide tag for the generation of pseudocontact shifts in DNA by site-specific ligation to a phosphorothioate group

Wu, Z., Lee, M. D., Carruthers, T. J., Szabo, M., Dennis, M. L., Swarbrick, J. D., Graham, B. & Otting, G., 21 Jun 2017, In : Bioconjugate Chemistry. 28, 6, p. 1741−1748 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Optimization of 2-anilino 4-amino substituted quinazolines into potent antimalarial agents with oral in vivo activity

Gilson, P. R., Tan, C., Jarman, K. E., Lowes, K. N., Curtis, J. M., Nguyen, W., Di Rago, A. E., Bullen, H. E., Prinz, B., Duffy, S., Baell, J. B., Hutton, C. A., Jousset Subroux, H., Crabb, B. S., Avery, V. M., Cowman, A. F. & Sleebs, B. E., 9 Feb 2017, In : Journal of Medicinal Chemistry. 60, 3, p. 1171-1188 18 p.

Research output: Contribution to journalArticleResearchpeer-review

Parallel and antiparallel cyclic d/l peptide nanotubes

Silk, M. R., Newman, J., Ratcliffe, J. C., White, J. F., Caradoc-Davies, T., Price, J. R., Perrier, S., Thompson, P. E. & Chalmers, D. K., 2017, In : Chemical Communications. 53, 49, p. 6613-6616 4 p.

Research output: Contribution to journalArticleResearchpeer-review

Performance of Deep and Shallow Neural Networks, the Universal Approximation Theorem, Activity Cliffs, and QSAR

Winkler, D. & Le, T. C., 1 Jan 2017, In : Molecular Informatics. 36, 1-2, 6 p., 1600118.

Research output: Contribution to journalArticleResearchpeer-review

Pharmacokinetics of the individual major components of polymyxin B and colistin in rats

Sivanesan, S., Roberts, K., Wang, J., Cheah, S-E., Thompson, P. E., Li, J., Nation, R. & Velkov, T., 27 Jan 2017, In : Journal of Natural Products. 80, 1, p. 225-229 5 p.

Research output: Contribution to journalArticleResearchpeer-review

Precise control of drug loading and release of an NSAID-polymer conjugate for long term osteoarthritis intra-articular drug delivery

Sulistio, A., Reyes-Ortega, F., D'Souza, A. M., Ng, S. M. Y., Valade, D., Quinn, J. F., Donohue, A. C., Mansfeld, F., Blencowe, A., Qiao, G., Prankerd, R., Quirk, S., Whittaker, M. R., Davis, T. P. & Tait, R. J., 1 Jan 2017, In : Journal of Materials Chemistry B. 5, 31, p. 6221-6226 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Prolonged immunomodulation in inflammatory arthritis using the selective Kv1.3 channel blocker HsTX1[R14A] and its PEGylated analog

Tanner, M. R., Tajhya, R. B., Huq, R., Gehrmann, E. J., Rodarte, K. E., Atik, M. A., Norton, R. S., Pennington, M. W. & Beeton, C., 1 Jul 2017, In : Clinical Immunology. 180, p. 45-57 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Purification and characterization of adenovirus core protein VII: A histone-like protein that is critical for adenovirus core formation

Sharma, G., Moria, N., Williams, M., Krishnarjuna, B. & Pouton, C. W., 1 Jul 2017, In : Journal of General Virology. 98, 7, p. 1785-1794 10 p., 000817.

Research output: Contribution to journalArticleResearchpeer-review

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Reinvestigation of the biological activity of D-allo-ShK protein

Dang, B., Chhabra, S., Pennington, M. W., Norton, R. S. & Kent, S. B. H., 2017, In : Journal of Biological Chemistry. 292, 30, p. 12599-12605 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Scaffolding the development of problem-solving skills in chemistry: Guiding novice students out of dead ends and false starts

Yuriev, E., Naidu, S., Schembri, L. S. & Short, J. L., 1 Jan 2017, In : Chemistry Education Research and Practice. 18, 3, p. 486-504 19 p.

Research output: Contribution to journalArticleResearchpeer-review

Screening of the ‘Open Scaffolds’ collection from Compounds Australia identifies a new chemical entity with anthelmintic activities against different developmental stages of the barber's pole worm and other parasitic nematodes

Preston, S., Jiao, Y., Baell, J. B., Keiser, J., Crawford, S., Koehler, A. V., Wang, T., Simpson, M. M., Kaplan, R. M., Cowley, K. J., Simpson, K. J., Hofmann, A., Jabbar, A. & Gasser, R. B., 1 Dec 2017, In : International Journal for Parasitology: Drugs and Drug Resistance. 7, 3, p. 286-294 9 p.

Research output: Contribution to journalArticleResearchpeer-review

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Selective Distance Measurements Using Triple Spin Labeling with Gd3+, Mn2+, and a Nitroxide

Wu, Z., Feintuch, A., Collauto, A., Adams, L. A., Aurelio, L., Graham, B., Otting, G. & Goldfarb, D., 2 Nov 2017, In : Journal of Physical Chemistry Letters. 8, 21, p. 5277-5282 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Solution conformations of a linked construct of the Zika virus NS2B-NS3 protease

Mahawaththa, M. C., Pearce, B. J. G., Szabo, M., Graham, B., Klein, C. D., Nitsche, C. & Otting, G., 1 Jun 2017, In : Antiviral Research. 142, p. 141-147 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Structure and activity of contryphan-Vc2: importance of the D-amino acid residue

Drane, S. B., Robinson, S. D., MacRaild, C., Chhabra, S., Chittoor, B., A V Morales, R., Leung, E. W. W., Belgi, A., Espino, S. S., Olivera, B. M., Robinson, A. J., Chalmers, D. K. & Norton, R. S., 1 Apr 2017, In : Toxicon : official journal of the International Society on Toxinology. 129, p. 113-122 10 p.

Research output: Contribution to journalArticleResearchpeer-review