Research Output 1977 2019

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22 Citations (Scopus)

Strategies for the development of conotoxins as new therapeutic leads

Brady, R., Baell, J. B. & Norton, R. S., 2013, In : Marine Drugs. 11, 7, p. 2293 - 2313 21 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
29 Citations (Scopus)

Structural analysis of the heparin-binding site of the NC1 domain of collagen XIV by CD and NMR

Montserret, R., Aubert-Foucher, E., McLeish, M. J., Hill, J. M., Ficheux, D., Jaquinod, M., Van Der Rest, M., Deleage, G. & Penin, F., 1999, In : Biochemistry. p. 6479 - 6488 10 p.

Research output: Contribution to journalArticleResearchpeer-review

19 Citations (Scopus)

Structural and biochemical characterization of the oxidoreductase NmDsbA3 from Neisseria meningitidis

Vivian, J., Scoullar, J., Robertson, A. L., Bottomley, S. P., Horne, H. J., Chin, K-Y. Y., Wielens, J., Thompson, P., Velkov, T., Piek, S., Byres, E., Beddoe, T. C., Wilce, M. CJ., Kahler, C. M., Rossjohn, J. & Scanlon, M., 2008, In : Journal of Biological Chemistry. 283, 47, p. 32452 - 32461 10 p.

Research output: Contribution to journalArticleResearchpeer-review

2 Citations (Scopus)

Structural and biochemical insights into the disulfide reductase mechanism of DsbD, an essential enzyme for neisserial pathogens

Smith, R. P., Mohanty, B., Mowlaboccus, S., Paxman, J. J., Williams, M. L., Headey, S. J., Wang, G., Subedi, P., Doak, B. C., Kahler, C. M., Scanlon, M. J. & Heras, B., 1 Jan 2018, In : Journal of Biological Chemistry. 293, 43, p. 16559-16571 13 p.

Research output: Contribution to journalArticleResearchpeer-review

51 Citations (Scopus)

Structural and functional analysis of the Josephin domain of the polyglutamine protein ataxin-3

Chow, M. K. M., Mackay, J. P., Whisstock, J. C., Scanlon, M. J. & Bottomley, S. P., 2004, In : Biochemical and Biophysical Research Communications. 322, 3, p. 387 - 394 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Structural and functional characterisation of a novel peptide from the Australian sea anemone Actinia tenebrosa

Elnahriry, K. A., Wai, D. C. C., Krishnarjuna, B., Badawy, N. N., Chittoor, B., MacRaild, C. A., Williams-Noonan, B. J., Surm, J. M., Chalmers, D. K., Zhang, A. H., Peigneur, S., Mobli, M., Tytgat, J., Prentis, P. & Norton, R. S., 1 Oct 2019, In : Toxicon. 168, p. 104-112 9 p.

Research output: Contribution to journalArticleResearchpeer-review

20 Citations (Scopus)

Structural and functional features of dimeric dihydrodiol dehydrogenase

Carbone, V., Hara, A. & El-Kabbani, O., 2008, In : Cellular and Molecular Life Sciences. 65, 10, p. 1464 - 1474 11 p.

Research output: Contribution to journalArticleResearchpeer-review

18 Citations (Scopus)

Structural and stereochemical revision of isocyanide and isothiocyanate amphilectenes from the Caribbean marine sponge Cribochalina sp.

Ciavatta, M. L., Gavagnin, M., Manzo, E., Puliti, R., Mattia, C. A., Mazzarella, L., Cimino, G., Simpson, J. S. & Garson, M. J., 2005, In : Tetrahedron. 61, 33, p. 8049 - 8053 5 p.

Research output: Contribution to journalArticleResearchpeer-review

13 Citations (Scopus)

Structural basis for 5′-end-specific recognition of single-stranded DNA by the R3H domain from human Sμbp-2

Jaudzems, K., Jia, X., Yagi, H., Zhulenkovs, D., Graham, B., Otting, G. & Liepinsh, E., 23 Nov 2012, In : Journal of Molecular Biology. 424, 1-2, p. 42-53 12 p.

Research output: Contribution to journalArticleResearchpeer-review

5 Citations (Scopus)

Structural basis for antibody targeting of the broadly expressed microbial polysaccharide poly-N-acetylglucosamine

Soliman, C., Walduck, A. K., Yuriev, E., Richards, J. S., Cywes-Bentley, C., Pier, G. B. & Ramsland, P. A., 1 Jan 2018, In : Journal of Biological Chemistry. 293, 14, p. 5079-5089 11 p.

Research output: Contribution to journalArticleResearchpeer-review

8 Citations (Scopus)

Structural basis for Ca2+-mediated interaction of the perforin C2 domain with lipid membranes

Yagi, H., Conroy, P. J., Leung, E. W. W., Law, R. H. P., Trapani, J. A., Voskoboinik, I., Whisstock, J. & Norton, R. S., 2015, In : Journal of Biological Chemistry. 290, 42, p. 25213-25226 14 p.

Research output: Contribution to journalArticleResearchpeer-review

13 Citations (Scopus)

Structural basis for epitope masking and strain specificity of a conserved epitope in an intrinsically disordered malaria vaccine candidate

De Almeida Vilela Morales, R., MacRaild, C. A., Seow, J. T-J., Krishnarjuna, B., Drinkwater, N., Rouet, R., Anders, R. F., Christ, D., McGowan, S. & Norton, R. S., 2015, In : Scientific Reports. 5, 10 p., 10103 .

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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245 Citations (Scopus)

Structural basis for modulation of a G-protein-coupled receptor by allosteric drugs

Dror, R., Green, H. F., Valant, C., Borhani, D. W., Valcourt, J. R., Pan, A. C., Arlow, D. H., Canals, M., Lane, J. R. D., Rahmani, R. S., Baell, J. B., Sexton, P., Christopoulos, A. & Shaw, D. E., 2013, In : Nature. 503, 7475, p. 295 - 299 5 p.

Research output: Contribution to journalArticleResearchpeer-review

Structural basis for the inhibition of poxvirus assembly by the antibiotic rifampicin

Garriga, D., Headey, S., Accurso, C., Gunzburg, M., Scanlon, M. & Coulibaly, F., 14 Aug 2018, In : Proceedings of the National Academy of Sciences of the United States of America. 115, 33, p. 8424-8429 6 p.

Research output: Contribution to journalArticleResearchpeer-review

3 Citations (Scopus)

Structural basis for the inhibition of voltage-gated sodium channels by conotoxin μO§-GVIIJ

Green, B. R., Gajewiak, J., Chhabra, S., Skalicky, J. J., Zhang, M. M., Rivier, J. E., Bulaj, G., Olivera, B. M., Yoshikami, D. & Norton, R., 25 Mar 2016, In : Journal of Biological Chemistry. 291, 13, p. 7205-7220 16 p.

Research output: Contribution to journalArticleResearchpeer-review

4 Citations (Scopus)

Structural basis for the selective binding of inhibitors to 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase from Staphylococcus aureus and Escherichia coli

Dennis, M. L., Pitcher, N. P., Lee, M. D., Debono, A. J., Wang, Z-C., Harjani, J. R., Rahmani, R., Cleary, B., Peat, T. S., Baell, J. B. & Swarbrick, J. D., 9 Jun 2016, In : Journal of Medicinal Chemistry. 59, 11, p. 5248-5263 16 p.

Research output: Contribution to journalArticleResearchpeer-review

22 Citations (Scopus)

Structural basis of nSH2 regulation and lipid binding in PI3Ka

Miller, M. S., Schmidt-Kittler, O., Bolduc, D. M., Brower, E. T., Chaves-Moreira, D., Allaire, M., Kinzler, K. W., Jennings, I., Thompson, P., Cole, P. A., Amzel, L. M., Vogelstein, B. & Gabelli, S. B., 2014, In : Oncotarget. 5, 14, p. 5198 - 5208 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
20 Citations (Scopus)

Structural biology of antibody recognition of carbohydrate epitopes and potential uses for targeted cancer immunotherapies

Dingjan, T., Spendlove, I., Durrant, L. G., Scott, A. M., Yuriev, E. & Ramsland, P. A., 2015, In : Molecular Immunology. 67, 2, p. 75-88 14 p.

Research output: Contribution to journalArticleResearchpeer-review

18 Citations (Scopus)

Structural biology of carbohydrate xenoantigens

Yuriev, E., Agostino, M. J., Farrugia, W., Christiansen, D., Sandrin, M. S. & Ramsland, P. A., 2009, In : Expert Opinion on Biological Therapy. 9, 8, p. 1017 - 1029 13 p.

Research output: Contribution to journalArticleResearchpeer-review

4 Citations (Scopus)

Structural determinant for cold inactivation of rodent L-xylulose reductase

Ishikura, S., Usami, N., El-Kabbani, O. & Hara, A., 2003, In : Biochemical and Biophysical Research Communications. 308, 1, p. 68 - 72 5 p.

Research output: Contribution to journalArticleResearchpeer-review

5 Citations (Scopus)

Structural Determinants for Small-Molecule Activation of Skeletal Muscle AMPK α2β2γ1 by the Glucose Importagog SC4

Ngoei, K. R. W., Langendorf, C. G., Ling, N. X. Y., Hoque, A., Varghese, S., Camerino, M. A., Walker, S. R., Bozikis, Y. E., Dite, T. A., Ovens, A. J., Smiles, W. J., Jacobs, R., Huang, H., Parker, M. W., Scott, J. W., Rider, M. H., Foitzik, R. C., Kemp, B. E., Baell, J. B. & Oakhill, J. S., 21 Jun 2018, In : Cell Chemical Biology. 25, 6, p. 728-737.e9 20 p.

Research output: Contribution to journalArticleResearchpeer-review

3 Citations (Scopus)

Structural dynamics of the potassium channel blocker ShK: SRLS analysis of 15N relaxation

Meirovitch, E., Tchaicheeyan, O., Sher, I., Norton, R. S. & Chill, J. H., 2015, In : Journal of Physical Chemistry B. 119, 49, p. 15130-15137 8 p.

Research output: Contribution to journalArticleResearchpeer-review

15 Citations (Scopus)

Structural predictions of adenosine 2B antagonist affinity using molecular field analysis

Song, Y., Coupar, I. M. & Iskander, M. N., 2001, In : Quantitative Structure-Activity Relationships. 20, p. 23 - 30 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Structural transformation in vesicles upon hydrolysis of phosphatidylethanolamine and phosphatidylcholine with phospholipase C

Fong, W. K., Sánchez-Ferrer, A., Rappolt, M., Boyd, B. J. & Mezzenga, R., 1 Jan 2019, (Accepted/In press) In : Langmuir. 35, 46, p. 14949-14958 10 p.

Research output: Contribution to journalArticleResearchpeer-review

6 Citations (Scopus)

Structure, folding and stability of a minimal homologue from Anemonia sulcata of the sea anemone potassium channel blocker ShK

Krishnarjuna, B., MacRaild, C. A., Sunanda, P., Morales, R. A. V., Peigneur, S., Macrander, J., Yu, H. H., Daly, M., Raghothama, S., Dhawan, V., Chauhan, S., Tytgat, J., Pennington, M. W. & Norton, R. S., Jan 2018, In : Peptides. 99, p. 169–178 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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11 Citations (Scopus)

Structure, Function, and Biosynthetic Origin of Octapeptin Antibiotics Active against Extensively Drug-Resistant Gram-Negative Bacteria

Velkov, T., Gallardo-Godoy, A., Swarbrick, J. D., Blaskovich, M. A. T., Elliott, A. G., Han, M., Thompson, P. E., Roberts, K. D., Huang, J. X., Becker, B., Butler, M. S., Lash, L. H., Henriques, S. T., Nation, R. L., Sivanesan, S., Sani, M. A., Separovic, F., Mertens, H., Bulach, D., Seemann, T. & 3 others, Owen, J., Li, J. & Cooper, M. A., 19 Apr 2018, In : Cell Chemical Biology. 25, 4, p. 380-391 12 p.

Research output: Contribution to journalArticleResearchpeer-review

4 Citations (Scopus)

Structure/function analysis of a critical disulfide bond in the active site of l-xylulose reductase

Zhao, H-T., Endo, S., Ishikura, S., Chung, R. P-T., Hogg, P. J., Hara, A. & El-Kabbani, O., 2009, In : Cellular and Molecular Life Sciences. 66, 9, p. 1570 - 1579 10 p.

Research output: Contribution to journalArticleResearchpeer-review

6 Citations (Scopus)

Structure-activity relationship exploration of Kv1.3 blockers based on diphenoxylate

Nguyen, W., Howard, B. L., Jenkins, D., Wulff, H., Thompson, P. & Manallack, D. T., 2012, In : Bioorganic and Medicinal Chemistry Letters. 22, 23, p. 7106 - 7109 4 p.

Research output: Contribution to journalArticleResearchpeer-review

15 Citations (Scopus)

Structure-activity relationship of flavonoids as potent inhibitors of carbonyl reductase 1 (CBR1)

Arai, Y., Endo, S., Miyagi, N., Abe, N., Miura, T., Nishinaka, T., Terada, T., Oyama, M., Goda, H., El-Kabbani, O., Hara, A., Matsunaga, T. & Ikari, A., 2015, In : Fitoterapia. 101, p. 51-56 6 p.

Research output: Contribution to journalArticleResearchpeer-review

25 Citations (Scopus)

Structure-activity relationships for the binding of polymyxins with human alpha-1-acid glycoprotein

Azad, M. A. K., Huang, J. X., Cooper, M. A., Roberts, K. D., Thompson, P., Nation, R. L., Li, J. & Velkov, T., 2012, In : Biochemical Pharmacology. 84, 3, p. 278 - 291 14 p.

Research output: Contribution to journalArticleResearchpeer-review

32 Citations (Scopus)

Structure-activity relationships of adenosines with heterocyclic N6-substituents

Ashton, T. D., Aumann, K. M., Baker, S. P., Schiesser, C. H. & Scammells, P. J., 2007, In : Bioorganic and Medicinal Chemistry Letters. 17, 24, p. 6779 - 6784 6 p.

Research output: Contribution to journalArticleResearchpeer-review

269 Citations (Scopus)

Structure-Activity Relationships of Polymyxin Antibiotics

Velkov, T., Thompson, P., Nation, R. L. & Li, J., 2010, In : Journal of Medicinal Chemistry. 53, p. 1898 - 1916 19 p.

Research output: Contribution to journalArticleResearchpeer-review

45 Citations (Scopus)

Structure-activity relationships of privileged structures lead to the discovery of novel biased ligands at the dopamine D2 receptor

Szabo, M., Klein Herenbrink, C., Christopoulos, A., Lane, J. R. D. & Capuano, B., 2014, In : Journal of Medicinal Chemistry. 57, 11, p. 4924 - 4939 16 p.

Research output: Contribution to journalArticleResearchpeer-review

1 Citation (Scopus)

Structure-Activity Relationship Studies of Tolfenpyrad Reveal Subnanomolar Inhibitors of Haemonchus contortus Development

Le, T. G., Kundu, A., Ghoshal, A., Nguyen, N. H., Preston, S., Jiao, Y., Ruan, B., Xue, L., Huang, F., Keiser, J., Hofmann, A., Chang, B. C. H., Garcia-Bustos, J., Wells, T. N. C., Palmer, M. J., Jabbar, A., Gasser, R. B. & Baell, J. B., 2019, In : Journal of Medicinal Chemistry. 62, 2, p. 1036-1053 8 p.

Research output: Contribution to journalArticleResearchpeer-review

23 Citations (Scopus)

Structure-activity relations of convulsant and anticonvulsant barbiturates: a computer-graphic-based pattern-recognition analysis

Andrews, P. R., Mark, L. C., Winkler, D. & Jones, G., 1983, In : Journal of Medicinal Chemistry. 26, 9, p. 1223-1229 7 p.

Research output: Contribution to journalArticleResearchpeer-review

8 Citations (Scopus)

Structure–activity studies of β-hairpin peptide inhibitors of the Plasmodium falciparum AMA1–RON2 interaction

Wang, G., Drinkwater, N., Drew, D. R., MacRaild, C. A., Chalmers, D. K., Mohanty, B., Lim, S. S., Anders, R. F., Beeson, J. G., Thompson, P. E., McGowan, S., Simpson, J. S., Norton, R. S. & Scanlon, M. J., 9 Oct 2016, In : Journal of Molecular Biology. 428, 20, p. 3986-3998 13 p.

Research output: Contribution to journalArticleResearchpeer-review

7 Citations (Scopus)

Structure and activity of contryphan-Vc2: importance of the D-amino acid residue

Drane, S. B., Robinson, S. D., MacRaild, C., Chhabra, S., Chittoor, B., A V Morales, R., Leung, E. W. W., Belgi, A., Espino, S. S., Olivera, B. M., Robinson, A. J., Chalmers, D. K. & Norton, R. S., 1 Apr 2017, In : Toxicon : official journal of the International Society on Toxinology. 129, p. 113-122 10 p.

Research output: Contribution to journalArticleResearchpeer-review

4 Citations (Scopus)

Structure and Characterisation of a Key Epitope in the Conserved C-Terminal Domain of the Malaria Vaccine Candidate MSP2

Seow, J., A V Morales, R., MacRaild, C. A., Bankala, K., McGowan, S., Dingjan, T., Jaipuria, G., Rouet, R., Wilde, K., Atreya, H. S., Richards, J. S., Anders, R. F., Christ, D., Drinkwater, N. & Norton, R. S., 24 Mar 2017, In : Journal of Molecular Biology. 429, 6, p. 836-846 11 p.

Research output: Contribution to journalArticleResearchpeer-review

13 Citations (Scopus)

Structure and dynamics of apical membrane antigen 1 from Plasmodium falciparum FVO

Lim, S. S., Yang, W. W., Krishnarjuna, B., Kannan Sivaraman, K., Chandrashekaran, I. R., Kass, I., MacRaild, C. A., Devine, S., Debono, C., Anders, R. F., Scanlon, M., Scammells, P. J., Norton, R. S. & McGowan, S., 2014, In : Biochemistry. 53, 46, p. 7310 - 7320 11 p.

Research output: Contribution to journalArticleResearchpeer-review

18 Citations (Scopus)

Structure and dynamics of glyceride lipid formulations, with propylene glycol and water

Warren, D., Chalmers, D. K. & Pouton, C. W., 2009, In : Molecular Pharmaceutics. 6, 2, p. 604 - 614 11 p.

Research output: Contribution to journalArticleResearchpeer-review

6 Citations (Scopus)

Structure and functional characterization of the conserved JAK interaction region in the intrinsically disordered N-terminus of SOCS5

Chandrashekaran, I. R., Mohanty, B., Linossi, E. M., Dagley, L. F., Leung, E. W. W., Murphy, J. M., Babon, J. J., Nicholson, S. E. & Norton, R. S., 2015, In : Biochemistry. 54, 30, p. 4672-4682 11 p.

Research output: Contribution to journalArticleResearchpeer-review

19 Citations (Scopus)

Structure and function of mu-conotoxins, peptide-based sodium channel blockers with analgesic activity

Green, B. R., Bulaj, G. & Norton, R. S., 2014, In : Future Medicinal Chemistry. 6, 15, p. 1677 - 1698 22 p.

Research output: Contribution to journalArticleResearchpeer-review

25 Citations (Scopus)

Structure and function of the oxidoreductase DsbA1 from Neisseria meningitidis

Vivian, J., Scoullar, J., Rimmer, K., Bushell, S. R., Beddoe, T. C., Wilce, M. C. J., Byres, E., Boyle, T. P., Doak, B. C., Simpson, J. S., Graham, B., Heras, B., Kahler, C. M., Rossjohn, J. & Scanlon, M., 2009, In : Journal of Molecular Biology. 394, 5, p. 931 - 943 13 p.

Research output: Contribution to journalArticleResearchpeer-review

49 Citations (Scopus)

Structure and function of the SPRY/B30.2 domain proteins involved in innate immunity

D'Cruz, A., Babon, J., Norton, R. S., Nicola, N. A. & Nicholson, S. E., 2013, In : Protein Science. 22, 1, p. 1 - 10 10 p.

Research output: Contribution to journalArticleResearchpeer-review

25 Citations (Scopus)

Structure and substrate-binding mechanism, of human Ap4A hydrolase

Swarbrick, J. D., Buyya, S., Gunawardana, D., Gayler, K. R., McLennan, A. G. & Gooley, P., 2005, In : Journal of Biological Chemistry. 280, p. 8471 - 8481 11 p.

Research output: Contribution to journalArticleResearchpeer-review

5 Citations (Scopus)

Structure and substrate fingerprint of aminopeptidase P from Plasmodium falciparum

Drinkwater, N., Kannan Sivaraman, K., Bamert, R. S., Rut, W., Mohamed, K., Vinh, N. B., Scammells, P. J., Drag, M. & McGowan, S., 27 Sep 2016, In : Biochemical Journal. 473, 19, p. 3189-3204 16 p.

Research output: Contribution to journalArticleResearchpeer-review

6 Citations (Scopus)

Structure-based design and development of functionalized mercaptoguanine derivatives as inhibitors of the folate biosynthesis pathway enzyme 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase from Staphylococcus aureus

Dennis, M., Chhabra, S., Wang, Z-C., Debono, A. J., Dolezal, O., Newman, J., Pitcher, N. P., Rahmani, R. S., Cleary, B., Barlow, N., Hattarki, M., Graham, B., Peat, T. S., Baell, J. B. & Swarbrick, J. D., 2014, In : Journal of Medicinal Chemistry. 57, 22, p. 9612 - 9626 15 p.

Research output: Contribution to journalArticleResearchpeer-review

3 Citations (Scopus)

Structure-based design of inhibitors of human L-xylulose reductase modelled into the active site of the enzyme

Carbone, V., Darmanin, C., Ishikura, S., Hara, A. & El-Kabbani, O., 2003, In : Bioorganic and Medicinal Chemistry Letters. 13, 8, p. 1469 - 1474 6 p.

Research output: Contribution to journalArticleResearchpeer-review

18 Citations (Scopus)

Structure-based discovery of human L-xylulose reductase inhibitors from database screening and molecular docking

Carbone, V., Ishikura, S., Hara, A. & El-Kabbani, O., 2005, In : Bioorganic & Medicinal Chemistry. 13, 2, p. 301 - 312 12 p.

Research output: Contribution to journalArticleResearchpeer-review