Research Output 1977 2019

Filter
Article
2015
21 Citations (Scopus)

Synthesis and biodistribution studies of 3H- and 64Cu-labeled dendritic polyglycerol and dendritic polyglycerol sulfate

Pant, K., Groger, D., Bergmann, R., Pietzsch, J., Steinbach, J., Graham, B., Spiccia, L., Berthon, F., Czarny, B., Devel, L., Dive, V., Stephan, H. & Haag, R., 2015, In : Bioconjugate Chemistry. 26, 5, p. 906-918 13 p.

Research output: Contribution to journalArticleResearchpeer-review

5 Citations (Scopus)

Synthesis and evaluation of phenoxymethylbenzamide analogues as anti-trypanosomal agents

Manos-Turvey, A., Watson, E. E., Sykes, M. L., Jones, A. J., Baell, J. B., Kaiser, M., Avery, V. M. & Payne, R. J., 2015, In : MedChemComm. 6, 3, p. 403 - 406 4 p.

Research output: Contribution to journalArticleOtherpeer-review

31 Citations (Scopus)

Synthesis and pharmacological evaluation of dual acting ligands targeting the adenosine A2A and dopamine D2 receptors for the potential treatment of Parkinson's disease

Jorg, M. T., May, L. T., Mak, F. S., Lee, K. C. K., Miller, N. D., Scammells, P. J. & Capuano, B., 2015, In : Journal of Medicinal Chemistry. 58, 2, p. 718 - 738 21 p.

Research output: Contribution to journalArticleResearchpeer-review

8 Citations (Scopus)

Synthesis and pharmacological evaluation of M4 muscarinic receptor positive allosteric modulators derived from VU10004

Huynh, T., Valant, C., Crosby, I. T., Sexton, P., Christopoulos, A. & Capuano, B., 2015, In : ACS Chemical Neuroscience. 6, 6, p. 838 - 844 7 p.

Research output: Contribution to journalArticleResearchpeer-review

63 Citations (Scopus)

Targeting virulence not viability in the search for future antibacterials

Heras, B., Scanlon, M. & Martin, J. L., 2015, In : British Journal of Clinical Pharmacology. 79, 2, p. 208 - 215 8 p.

Research output: Contribution to journalArticleResearchpeer-review

7 Citations (Scopus)

The carbohydrate-binding promiscuity of Euonymus europaeus lectin is predicted to involve a single binding site

Agostino, M. J., Velkov, T., Dingjan, T., Williams, S. J., Yuriev, E. & Ramsland, P. A., 2015, In : Glycobiology. 25, 1, p. 101 - 114 14 p.

Research output: Contribution to journalArticleResearchpeer-review

18 Citations (Scopus)

Thermostability and reversibility of silver nanoparticle-protein binding

Wang, B., Seabrook, S. A., Nedumpully-Govindan, P., Chen, P., Yin, H., Waddington, L. J., Epa, V. C., Winkler, D. A., Kirby, J. K., Ding, F. & Ke, P. C., 2015, In : Physical Chemistry Chemical Physics. 17, 3, p. 1728-1739 12 p.

Research output: Contribution to journalArticleResearchpeer-review

15 Citations (Scopus)

Towards computational design of zeolite catalysts for CO2 reduction

Thornton, A. W., Winkler, D. A., Liu, M. S., Haranczyk, M. & Kennedy, D., 2015, In : RSC Advances. 5, 55, p. 44361-44370 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
57 Citations (Scopus)

Transformation of poorly water-soluble drugs into lipophilic ionic liquids enhances oral drug exposure from lipid based formulations

Sahbaz, Y., Williams, H. D., Nguyen, T-H., Saunders, J. A., Ford, L., Charman, S. A., Scammells, P. J. & Porter, C. J., 2015, In : Molecular Pharmaceutics. 12, 6, p. 1980 - 1991 12 p.

Research output: Contribution to journalArticleResearchpeer-review

10 Citations (Scopus)

Up-regulation of carbonyl reductase 1 renders development of doxorubicin resistance in human gastrointestinal cancers

Matsunaga, T., Kezuka, C., Morikawa, Y., Suzuki, A., Endo, S., Iguchi, K., Miura, T., Nishinaka, T., Terada, T., El-Kabbani, O., Hara, A. & Ikari, A., 2015, In : Biological & Pharmaceutical Bulletin. 38, 9, p. 1309-1319 11 p.

Research output: Contribution to journalArticleResearchpeer-review

14 Citations (Scopus)

Using active learning strategies to shift student attitudes and behaviours about learning and teaching in a research intensive educational context

White, P. J., Larson, I., Styles, K., Yuriev, E., Evans, D. R., Short, J. L., Rangachari, P. K., Malone, D. T., Davie, B., Naidu, S. & Eise, N., 2015, In : Pharmacy Education. 15, 1, p. 116-126 11 p.

Research output: Contribution to journalArticleResearchpeer-review

2016
1 Citation (Scopus)

1H, 13C and 15N resonance assignments of a C-terminal domain of human CHD1

Mohanty, B., Silva, A. P. G., Mackay, J. P. & Ryan, D. P., 1 Apr 2016, In : Biomolecular NMR Assignments. 10, 1, p. 31-34 4 p.

Research output: Contribution to journalArticleOtherpeer-review

20 Citations (Scopus)

4-phenylpyridin-2-one derivatives: a novel class of positive allosteric modulator of the M1 muscarinic acetylcholine receptor

Mistry, S. N., Jorg, M., Lim, H., Vinh, N. B., Sexton, P. M., Capuano, B., Christopoulos, A., Lane, J. R. & Scammells, P. J., 14 Jan 2016, In : Journal of Medicinal Chemistry. 59, 1, p. 388-409 22 p.

Research output: Contribution to journalArticleResearchpeer-review

15 Citations (Scopus)

Accurate and interpretable nanoSAR models from genetic programming-based decision tree construction approaches

Oksel, C., Winkler, D. A., Ma, C. Y., Wilkins, T. & Wang, X. Z., 2016, In : Nanotoxicology. 10, 7, p. 1001-1012 12 p.

Research output: Contribution to journalArticleResearchpeer-review

16 Citations (Scopus)

Adopting an active learning approach to teaching in a research-intensive higher education context transformed staff teaching attitudes and behaviours

White, P. J., Larson, I., Styles, K., Yuriev, E., Evans, D. R., Rangachari, P. K., Short, J. L., Exintaris, B., Malone, D. T., Davie, B., Eise, N., McNamara, K. & Naidu, S., 2016, In : Higher Education Research and Development. 35, 3, p. 619-633 15 p.

Research output: Contribution to journalArticleResearchpeer-review

27 Citations (Scopus)

A minimized human insulin-receptor-binding motif revealed in a Conus geographus venom insulin

Menting, J. G., Gajewiak, J., MacRaild, C., Chou, D. H. C., Disotuar, M. M., Smith, N. A., Miller, C., Erchegyi, J., Rivier, J. E., Olivera, B. M., Forbes, B. E., Smith, B. J., Norton, R., Safavi-Hemami, H. & Lawrence, M. C., 1 Oct 2016, In : Nature Structural and Molecular Biology. 23, 10, p. 916-920 5 p.

Research output: Contribution to journalArticleResearchpeer-review

1 Citation (Scopus)

An alternative approach to the synthesis of peptides containing a cystathionine bridge

Harjani, J. R., Yap, B. K., Norton, R. S. & Baell, J. B., 9 Jun 2016, In : Tetrahedron. 72, 23, p. 3256-3261 6 p.

Research output: Contribution to journalArticleResearchpeer-review

9 Citations (Scopus)

A naturally occurring peptide with an elementary single disulfide-directed β-hairpin fold

Robinson, S., Chhabra, S., Belgi, A., Chittoor, B., Safavi-Hemami, H., Robinson, A. J., Papenfuss, A. T., Purcell, A. & Norton, R., 2 Feb 2016, In : Structure. 24, 2, p. 293-299 7 p.

Research output: Contribution to journalArticleResearchpeer-review

19 Citations (Scopus)

An Experimental and Computational Approach to the Development of ZnO Nanoparticles that are Safe by Design

Le, T. C., Yin, H., Chen, R., Chen, Y., Zhao, L., Casey, P. S., Chen, C. & Winkler, D. A., 2016, In : Small. 12, 26, p. 3568-3577 10 p.

Research output: Contribution to journalArticleResearchpeer-review

8 Citations (Scopus)

A novel chemical biology approach for mapping of polymyxin lipopeptide antibody binding epitopes

Velkov, T., Yun, B., Schneider, E. K., Azad, M. A. K., Dolezal, O., Morris, F. C., Nation, R. L., Wang, J., Chen, K., Yu, H., Wang, L., Thompson, P. E., Roberts, K. D. & Li, J., 2016, In : ACS Infectious Diseases. 2, 5, p. 341-351 11 p.

Research output: Contribution to journalArticleResearchpeer-review

5 Citations (Scopus)

A novel compound which sensitizes BRAF wild-type melanoma cells to vemurafenib in a TRIM16-dependent manner

Sutton, S. K., Carter, D. R., Kim, P., Tan, O., Arndt, G. M., Zhang, X. D., Baell, J., Noll, B. D., Wang, S., Kumar, N., McArthur, G. A., Cheung, B. B. & Marshall, G. M., 1 Aug 2016, In : Oncotarget. 7, 32, p. 52166-52178 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
6 Citations (Scopus)

A novel serpin regulatory mechanism: SERPINB9 is reversibly inhibited by vicinal disulfide bond formation in the reactive center loop

Mangan, M. S. J., Bird, C. H., Kaiserman, D., Matthews, A. Y., Hitchen, C., Steer, D. L., Thompson, P. E. & Bird, P. I., 12 Feb 2016, In : Journal of Biological Chemistry. 291, 7, p. 3626-3638 13 p.

Research output: Contribution to journalArticleResearchpeer-review

6 Citations (Scopus)

Antagonism of the proinflammatory and pronociceptive actions of canonical and biased agonists of protease-activated receptor-2

Lieu, T., Savage, E., Zhao, P., Edgington-Mitchell, L., Barlow, N., Bron, R., Poole, D. P., McLean, P., Lohman, R. J., Fairlie, D. P. & Bunnett, N. W., 1 Sep 2016, In : British Journal of Pharmacology. 173, 18, p. 2752-2765 14 p.

Research output: Contribution to journalArticleResearchpeer-review

16 Citations (Scopus)

Antibody recognition of disordered antigens

Macraild, C. A., Richards, J. S., Anders, R. F. & Norton, R. S., 5 Jan 2016, In : Structure. 24, 1, p. 148-157 10 p.

Research output: Contribution to journalArticleResearchpeer-review

57 Citations (Scopus)

A renaissance of neural networks in drug discovery

Baskin, I. I., Winkler, D. & Tetko, I. V., 2016, In : Expert Opinion on Drug Delivery. 11, 8, p. 785-795 11 p.

Research output: Contribution to journalArticleResearchpeer-review

8 Citations (Scopus)

A thrombopoietin receptor antagonist is capable of depleting myelofibrosis hematopoietic stem and progenitor cells

Wang, X., Haylock, D., Hu, C. S., Kowalczyk, W., Jiang, T., Qiu, J., Mosoyan, G., He, W., Marshall, N., Mascarenhas, J., Tarasova, A., Brody, J., Winkler, D. & Hoffman, R., 30 Jun 2016, In : Blood. 127, 26, p. 3398-3409 12 p.

Research output: Contribution to journalArticleResearchpeer-review

6 Citations (Scopus)

Beta amino acid-modified and fluorescently labelled kisspeptin analogues with potent KISS1R activity

Camerino, M., Liu, M., Moriya, S., Kitahashi, T., Mahgoub, A., Mountford, S., Chalmers, D. K., Soga, T., Parhar, I. & Thompson, P., 1 Jun 2016, In : Journal of Peptide Science. 22, 6, p. 406-414 9 p.

Research output: Contribution to journalArticleResearchpeer-review

5 Citations (Scopus)

Binding of CFA/I pili of enterotoxigenic Escherichia coli to asialo-GM1 is mediated by the minor pilin CfaE

Madhavan, T. P. V., Riches, J. D., Scanlon, M. J., Ulett, G. C. & Sakellaris, H., 1 May 2016, In : Infection and Immunity. 84, 5, p. 1642-1649 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
59 Citations (Scopus)

Cell permeability beyond the rule of 5

Matsson, P., Doak, B. C., Over, B. & Kihlberg, J., 1 Jun 2016, In : Advanced Drug Delivery Reviews. 101, p. 42-61 20 p.

Research output: Contribution to journalArticleResearchpeer-review

8 Citations (Scopus)

Cellular uptake and photo-cytotoxicity of a gadolinium(III)-DOTA-naphthalimide complex "clicked" to a lipidated tat peptide

O'Malley, W., Rubbiani, R., Aulsebrook, M., Grace, M., Spiccia, L., Tuck, K., Gasser, G. & Graham, B., 1 Feb 2016, In : Molecules. 21, 2, p. 1-16 16 p., 194.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
13 Citations (Scopus)

Clickable Photoaffinity Ligands for Metabotropic Glutamate Receptor 5 Based on Select Acetylenic Negative Allosteric Modulators

Gregory, K., Velagaleti, R., Thal, D. M., Brady, R. M., Christopoulos, A., Conn, P. J. & Lapinsky, D. J., 15 Jul 2016, In : ACS Chemical Biology. 11, 7, p. 1870-1879 10 p.

Research output: Contribution to journalArticleResearchpeer-review

31 Citations (Scopus)

Compound heterozygous FXN mutations and clinical outcome in Friedreich ataxia

Galea, C., Huq, A., Lockhart, P. J., Tai, G., Corben, L., Yiu, E. M., Gurrin, L. C., Lynch, D. R., Gelbard, S., Durr, A., Pousset, F., Parkinson, M., Labrum, R., Giunti, P., Perlman, S. L., Delatycki, M. & Evans-Galea, M. V., 2016, In : Annals of Neurology. 79, 3, p. 485-495 11 p.

Research output: Contribution to journalArticleResearchpeer-review

10 Citations (Scopus)

Comprehensive vibrational spectroscopic investigation of trans,trans,trans-[Pt(N3)2(OH)2(py)2], a Pt(IV) diazido anticancer prodrug candidate

Vernooij, R. R., Joshi, T., Shaili, E., Kubeil, M., Appadoo, D. R. T., Izgorodina, E. I., Graham, B., Sadler, P. J., Wood, B. & Spiccia, L., 20 Jun 2016, In : Inorganic Chemistry. 55, 12, p. 5983-5992 10 p.

Research output: Contribution to journalArticleResearchpeer-review

4 Citations (Scopus)
4 Citations (Scopus)

Crossword puzzles for chemistry education: Learning goals beyond vocabulary

Yuriev, E., Capuano, B. & Short, J. L., 2016, In : Chemistry Education Research and Practice. 17, 3, p. 532-554 23 p.

Research output: Contribution to journalArticleResearchpeer-review

10 Citations (Scopus)

Determination of ligand binding modes in weak protein–ligand complexes using sparse NMR data

Mohanty, B., Williams, M., Doak, B. C., Vazirani, M., Ilyichova, O., Wang, G., Bermel, W., Simpson, J. S., Chalmers, D. K., King, G. F., Mobli, M. & Scanlon, M. J., Nov 2016, In : Journal of Biomolecular NMR. 66, 3, p. 195-208 14 p.

Research output: Contribution to journalArticleResearchpeer-review

1 Citation (Scopus)
6 Citations (Scopus)

Development of single and mixed isoform selectivity PI3Kδ inhibitors by targeting Asn836 of PI3Kδ

Miller, M. S., Mountford, S. J., Pinson, J-A., Zheng, Z., Künzli, M., Patel, V., Hogg, S. J., Shortt, J., Jennings, I. G. & Thompson, P. E., 1 Oct 2016, In : Bioorganic and Medicinal Chemistry Letters. 26, 19, p. 4790-4794 5 p.

Research output: Contribution to journalArticleResearchpeer-review

11 Citations (Scopus)

Discovery and antiplatelet activity of a selective PI3Kβ inhibitor (MIPS-9922)

Zheng, Z., Pinson, J. A., Mountford, S. J., Orive, S., Schoenwaelder, S. M., Shackleford, D., Powell, A., Nelson, E. M., Hamilton, J. R., Jackson, S., Jennings, I. G. & Thompson, P. E., 21 Oct 2016, In : European Journal of Medicinal Chemistry. 122, p. 339-351 13 p.

Research output: Contribution to journalArticleResearchpeer-review

53 Citations (Scopus)

Discovery and optimization of materials using evolutionary approaches

Le, T. C. & Winkler, D. A., 2016, In : Chemical Reviews. 116, 10, p. 6107-6132 26 p.

Research output: Contribution to journalArticleResearchpeer-review

11 Citations (Scopus)

Electrophilic Activation of P-Alkynes in the Synthesis of P-Substituted and P-Centered Heterocycles

Gupta, A. & Flynn, B. L., 20 May 2016, In : Journal of Organic Chemistry. 81, 10, p. 4012-4019 8 p.

Research output: Contribution to journalArticleResearchpeer-review

9 Citations (Scopus)

Enabling noninvasive systemic delivery of the Kv1.3-blocking peptide HsTX1[R14A] via the buccal mucosa

Jin, L., Boyd, B. J., Larson, I. C., Pennington, M. W., Norton, R. S. & Nicolazzo, J. A., 1 Jul 2016, In : Journal of Pharmaceutical Sciences. 105, 7, p. 2173-2179 7 p.

Research output: Contribution to journalArticleResearchpeer-review

13 Citations (Scopus)

Enantiomeric two-armed lanthanide-binding tags for complementary effects in paramagnetic NMR spectroscopy

Lee, M. D., Dennis, M. L., Swarbrick, J. D. & Graham, B., 2016, In : Chemical Communications. 52, 51, p. 7954-7957 4 p.

Research output: Contribution to journalArticleResearchpeer-review

25 Citations (Scopus)

Extracellular loop 2 of the adenosine A1 receptor has a key role in orthosteric ligand affinity and agonist efficacy

Nguyen, A. T. N., Baltos, J-A., Thomas, T., Nguyen, T. D., Lopez Munoz, L., Gregory, K. J., White, P. J., Sexton, P. M., Christopoulos, A. & May, L. T., 1 Dec 2016, In : Molecular Pharmacology. 90, 6, p. 703-714 12 p.

Research output: Contribution to journalArticleResearchpeer-review

21 Citations (Scopus)
16 Citations (Scopus)

Flipped classroom implementation: A case report of two higher education institutions in the United States and Australia

McLaughlin, J. E., White, P. J., Khanova, J. & Yuriev, E., 2016, In : Computers in the Schools. 33, 1, p. 24-37 14 p.

Research output: Contribution to journalArticleResearchpeer-review

5 Citations (Scopus)

Fragment based strategies for discovery of novel HIV-1 reverse transcriptase and integrase inhibitors

Latham, C. F., La, J., Tinetti, R. N., Chalmers, D. K. & Tachedjian, G., 2016, In : Current Topics in Medicinal Chemistry. 16, 10, p. 1135-1153 19 p.

Research output: Contribution to journalArticleResearchpeer-review

17 Citations (Scopus)

From sphingosine kinase to dihydroceramide desaturase: a structure-activity relationship (SAR) study of the enzyme inhibitory and anticancer activity of 4-((4-(4-chlorophenyl)thiazol-2-yl)amino)phenol (SKI-II)

Aurelio, L., Scullino, C. V., Pitman, M. R., Sexton, A. E., Oliver, V., Davies, L., Rebello, R. J., Furic, L., Creek, D. J., Pitson, S. M. & Flynn, B. L., 11 Feb 2016, In : Journal of Medicinal Chemistry. 59, 3, p. 965-984 20 p.

Research output: Contribution to journalArticleResearchpeer-review

16 Citations (Scopus)

Glyceride-mimetic prodrugs incorporating self-immolative spacers promote lymphatic transport, avoid first-pass metabolism, and enhance oral bioavailability

Hu, L., Quach, T., Han, S., Lim, S. F., Yadav, P., Senyschyn, D., Trevaskis, N. L., Simpson, J. S. & Porter, C. J. H., 2016, In : Angewandte Chemie - International Edition. 55, 44, p. 13700 –13705 6 p.

Research output: Contribution to journalArticleResearchpeer-review