Research Output 1977 2019

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2008
33 Citations (Scopus)

Prediction of drug solubility from molecular structure using a drug-like training set

Huuskonen, J., Livingstone, D. J. & Manallack, D. T., 2008, In : SAR and QSAR in Environmental Research. 19, 3-4, p. 191 - 212 22 p.

Research output: Contribution to journalArticleResearchpeer-review

9 Citations (Scopus)
16 Citations (Scopus)

Selectivity determinants of inhibitor binding to human 20alpha- hydroxysteroid dehydrogenase: Crystal structure of the enzyme in ternary complex with coenzyme and the potent inhibitor 3,5-dichlorosalicylic acid

Dhagat, U., Endo, S., Sumii, R., Hara, A. & El-Kabbani, O., 2008, In : Journal of Medicinal Chemistry. 51, 15, p. 4844 - 4848 5 p.

Research output: Contribution to journalArticleResearchpeer-review

2 Citations (Scopus)

Solid phase synthesis and circular dichroism analysis of (i -> i + 4) cyclic lactam analogues of kisspeptin

Camerino, M. A., Kong, D. C. M., Chalmers, D. K. & Thompson, P., 2008, In : International Journal of Peptide Research and Therapeutics. 14, 4, p. 323 - 331 9 p.

Research output: Contribution to journalArticleResearchpeer-review

19 Citations (Scopus)

Structural and biochemical characterization of the oxidoreductase NmDsbA3 from Neisseria meningitidis

Vivian, J., Scoullar, J., Robertson, A. L., Bottomley, S. P., Horne, H. J., Chin, K-Y. Y., Wielens, J., Thompson, P., Velkov, T., Piek, S., Byres, E., Beddoe, T. C., Wilce, M. CJ., Kahler, C. M., Rossjohn, J. & Scanlon, M., 2008, In : Journal of Biological Chemistry. 283, 47, p. 32452 - 32461 10 p.

Research output: Contribution to journalArticleResearchpeer-review

20 Citations (Scopus)

Structural and functional features of dimeric dihydrodiol dehydrogenase

Carbone, V., Hara, A. & El-Kabbani, O., 2008, In : Cellular and Molecular Life Sciences. 65, 10, p. 1464 - 1474 11 p.

Research output: Contribution to journalArticleResearchpeer-review

11 Citations (Scopus)
4 Citations (Scopus)

Structure of monkey dimeric dihydrodiol dehydrogenase in complex with isoascorbic acid

Carbone, V., Sumii, R., Ishikura, S., Asada, Y., Hara, A. & El-Kabbani, O., 2008, In : Acta Crystallographica Section D: Biological Crystallography. 64, Part 5, p. 532 - 542 11 p.

Research output: Contribution to journalArticleResearchpeer-review

9 Citations (Scopus)

Structures of dimeric dihydrodiol dehydrogenase apoenzyme and inhibitor complex: Probing the subunit interface with site-directed mutagenesis

Carbone, V., Endo, S., Sumii, R., Chung, R. P-T., Matsunaga, T., Hara, A. & El-Kabbani, O., 2008, In : Proteins: Structure, Function, and Bioinformatics. 70, 1, p. 176 - 187 12 p.

Research output: Contribution to journalArticleResearchpeer-review

52 Citations (Scopus)

Synthesis, copper(II) complexation, 64Cu-labeling, and bioconjugation of a new bis(2-pyridylmethyl) derivative of 1,4,7- triazacyclononane

Gasser, G. A., Tjioe, L., Graham, B., Belousoff, M. J., Juran, S., Walther, M., Kunstler, J-U., Bergmann, R., Stephan, H. & Spiccia, L., 2008, In : Bioconjugate Chemistry. 19, p. 719 - 730 12 p.

Research output: Contribution to journalArticleResearchpeer-review

31 Citations (Scopus)

Synthesis, X-Ray Crystal Structures, and Phosphate Ester Cleavage Properties of bis(2-Pyridylmethyl)amine Copper(II) Complexes with Guanidinium Pendant Groups

Belousoff, M. J., Tjioe, L., Graham, B. & Spiccia, L., 2008, In : Inorganic Chemistry. 47, 19, p. 8641 - 8651 11 p.

Research output: Contribution to journalArticleResearchpeer-review

20 Citations (Scopus)

Synthesis and Biological Evaluation of Chalcones as Inhibitors of the Voltage-Gated Potassium Channel Kv1.3

Cianci, J., Baell, J. B., Flynn, B. L., Gable, R. W., Mould, J., Paul, D. & Harvey, A. J., 2008, In : Bioorganic and Medicinal Chemistry Letters. 18, 6, p. 2055 - 2061 7 p.

Research output: Contribution to journalArticleResearchpeer-review

14 Citations (Scopus)

Synthesis and cannabinoid activity of 1-substituted-indole-3-oxadiazole derivatives: novel agonists for the CB1 receptor

Moloney, G. P., Angus, J. A., Robertson, A. D., Stoermer, M. J., Robinson, M. S., Wright, C. E., McRae, K. & Christopoulos, A., 2008, In : European Journal of Medicinal Chemistry. 43, 1, p. 513 - 539 26 p.

Research output: Contribution to journalArticleResearchpeer-review

5 Citations (Scopus)

Synthesis and cannabinoid activity of a variety of 2,3-substituted 1-benzo[b]thiophen derivatives and 2,3-substituted benzofuran: Novel agonists for the CB1 receptor

Moloney, G. P., Angus, J. A., Robertson, A. D., Stoermer, M. J., Robinson, M., Lay, L., Wright, C. E., McRae, K. & Christopoulos, A., 28 Jul 2008, In : Australian Journal of Chemistry. 61, 7, p. 484-499 16 p.

Research output: Contribution to journalArticleResearchpeer-review

10 Citations (Scopus)

Synthesis and preliminary pharmacological evaluation of 4'-arylalkyl analogues of clozapine. IV. the effects of aromaticity and isosteric replacement

Capuano, B., Crosby, I. T., Lloyd, E. J., Podloucka, A. & Taylor, D., 2008, In : Australian Journal of Chemistry. 61, 12, p. 930 - 940 11 p.

Research output: Contribution to journalArticleResearchpeer-review

3 Citations (Scopus)

Synthesis of 1,1,3,3-tetraalkylisoindolines using a microwave-assisted Grignard reaction

Foitzik, R., Bottle, S. E., White, J. M. & Scammells, P. J., 2008, In : Australian Journal of Chemistry. 61, 3, p. 168 - 171 4 p.

Research output: Contribution to journalArticleResearchpeer-review

27 Citations (Scopus)

Synthesis of bivalent beta2-adrenergic and adenosine A 1 receptor ligands

Karellas, P., McNaughton, M., Baker, S. P. & Scammells, P. J., 2008, In : Journal of Medicinal Chemistry. 51, 19, p. 6128 - 6137 10 p.

Research output: Contribution to journalArticleResearchpeer-review

5 Citations (Scopus)

Synthesis of succinimidoalkylbenzaldehyde analogues: Potential bifunctional linkers for bioconjugation

Crosby, I. T., Pietersz, G. A. & Ripper, J. A., 2008, In : Australian Journal of Chemistry. 61, 2, p. 138 - 143 6 p.

Research output: Contribution to journalArticleResearchpeer-review

63 Citations (Scopus)

The design and synthesis of biodegradable pyridinium ionic liquids

Harjani, J. R., Singer, R. D., Garcia, M. T. & Scammells, P. J., 2008, In : Green Chemistry. 10, 4, p. 436 - 438 3 p.

Research output: Contribution to journalArticleResearchpeer-review

5 Citations (Scopus)

The Dotted Cap Notation: A concise notation for describing variegated dendrimers

Roberts, B. P., Scanlon, M., Krippner, G. Y. & Chalmers, D. K., 2008, In : New Journal of Chemistry. 32, 9, p. 1543 - 1554 12 p.

Research output: Contribution to journalArticleResearchpeer-review

15 Citations (Scopus)

The role of the conserved threonine in P450BM3 oxygen activation: Substrate-determined hydroxylation activity of the Thr268Ala mutant

Cryle, M. J. & De Voss, J. J., 25 Jan 2008, In : ChemBioChem. 9, 2, p. 261-266 6 p.

Research output: Contribution to journalArticleResearchpeer-review

27 Citations (Scopus)

The structural impact of a polyglutamine tract is location-dependent

Robertson, A. L., Horne, H. J., Ellisdon, A. M., Thomas, B., Scanlon, M. & Bottomley, S. P., 2008, In : Biophysical Journal. 95, 12, p. 5922 - 5930 9 p.

Research output: Contribution to journalArticleResearchpeer-review

3 Citations (Scopus)

The use of local surface properties for molecular superimposition

Manallack, D. T., 2008, In : Journal of Molecular Modeling. 14, 9, p. 797 - 805 9 p.

Research output: Contribution to journalArticleResearchpeer-review

3 Citations (Scopus)

Unusual binding mode of the 2S4R stereoisomer of the potent aldose reductase cyclic imide inhibitor fidarestat (2S4S) in the 15 K crystal structure of the ternary complex refined at 0.78 A resolution: Implications for the inhibition mechanism

Zhao, H-T., Hazemann, I., Mitschler, A., Carbone, V., Joachimiak, A., Ginell, S. L., Podjarny, A. D. & El-Kabbani, O., 2008, In : Journal of Medicinal Chemistry. 51, 5, p. 1478 - 1481 4 p.

Research output: Contribution to journalArticleResearchpeer-review

2007
7 Citations (Scopus)

A high-resolution solution structure of a trypanosomatid FYVE domain

Mertens, H. D. T., Callaghan, J. M., Swarbrick, J. D., McConville, M. J. & Gooley, P., 2007, In : Protein Science. 16, 11, p. 2552 - 2559 8 p.

Research output: Contribution to journalArticleResearchpeer-review

7 Citations (Scopus)

Aminimides as potential CNS acting agents. I. Design, synthesis, and receptor binding of 4'-aryl aminimide analogues of clozapine as prospective novel antipsychotics

Capuano, B., Crosby, I. T., Lloyd, T., Neve, J. E. & Taylor, D., 2007, In : Australian Journal of Chemistry. 60, 9, p. 673 - 684 12 p.

Research output: Contribution to journalArticleResearchpeer-review

24 Citations (Scopus)

A salicylic acid-based analogue discovered from virtual screening as a potent inhibitor of human 20alpha-hydroxysteroid dehydrogenase

Dhagat, U., Carbone, V., Chung, R. P-T., Matsunaga, T., Endo, S., Hara, A. & El-Kabbani, O., 2007, In : Medicinal Chemistry. 3, 6, p. 546 - 550 5 p.

Research output: Contribution to journalArticleResearchpeer-review

1 Citation (Scopus)

Backbone and side chain 1H, 15N and 13C assignments for the reduced form of the oxidoreductase protein DsbA from Vibrio cholerae

Horne, H. J. & Scanlon, M., 2007, In : Biomolecular NMR Assignments. 1, p. 75 - 76 2 p.

Research output: Contribution to journalArticleResearchpeer-review

29 Citations (Scopus)

Biodegradable ionic liquids: Selected synthetic applications

Bouquillon, S., Courant, T., Dean, D., Gathergood, N., Morrissey, S., Pegot, B., Scammells, P. J. & Singer, R. D., 2007, In : Australian Journal of Chemistry. 60, 11, p. 843 - 847 5 p.

Research output: Contribution to journalArticleResearchpeer-review

38 Citations (Scopus)

Carbohydrate residues downstream of the terminal Galalpha(1,3)Gal epitope modulate the specificity of xenoreactive antibodies

Milland, J., Yuriev, E., Xing, P-X., McKenzie, I., Ramsland, P. A. & Sandrin, M. S., 2007, In : Immunology and Cell Biology. 85, 8, p. 623 - 632 10 p.

Research output: Contribution to journalArticleResearchpeer-review

7 Citations (Scopus)

Characterization of rat and mouse NAD+-dependent 3alpha/17beta/20alpha-hydroxysteroid dehydrogenases and identification of substrate specificity determinants by site-directed mutagenesis

Endo, S., Sanai, M., Horie, K., Matsunaga, T., Ishikura, S., Tajima, K., El-Kabbani, O. & Hara, A., 2007, In : Archives of Biochemistry and Biophysics. 467, 1, p. 76 - 86 11 p.

Research output: Contribution to journalArticleResearchpeer-review

16 Citations (Scopus)

Dual acting antioxidant A1 adenosine receptor agonists

Gregg, A. D., Bottle, S. E., Devine, S., Figler, H., Linden, J., White, P. J., Pouton, C. W., Urmaliya, V. & Scammells, P. J., 2007, In : Bioorganic and Medicinal Chemistry Letters. 17, 19, p. 5437 - 5441 5 p.

Research output: Contribution to journalArticleResearchpeer-review

4 Citations (Scopus)

Effect of a novel partial adenosine A1 receptor agonist VCP102 in reducing ischemic damage in the mouse heart

Butcher, A., Gregg, A. D., Scammells, P. J. & Rose'Meyer, R. B., 2007, In : Drug Development Research. 68, 8, p. 529 - 537 9 p.

Research output: Contribution to journalArticleResearchpeer-review

16 Citations (Scopus)

Enzymatic characteristics of an aldo-keto reductase family protein (AKR1C15) and its localization in rat tissues

Endo, S., Matsunaga, T., Horie, K., Tajima, K., Bunai, Y., Carbone, V., El-Kabbani, O. & Hara, A., 2007, In : Archives of Biochemistry and Biophysics. 465, 1, p. 136 - 147 12 p.

Research output: Contribution to journalArticleResearchpeer-review

29 Citations (Scopus)

Examination of the role of intestinal fatty acid-binding protein in drug absorption using a parallel artificial membrane permeability assay

Velkov, T., Horne, H. J., Laguerre, A. K., Jones, E. D., Scanlon, M. & Porter, C. J., 2007, In : Chemistry and Biology. 14, 4, p. 453 - 465 13 p.

Research output: Contribution to journalArticleResearchpeer-review

11 Citations (Scopus)

Facile determination of the absolute stereochemistry of hydroxy fatty acids by GC: application to the analysis of fatty acid oxidation by a P450BM3 mutant

Cryle, M. J. & De Voss, J. J., 12 Mar 2007, In : Tetrahedron Asymmetry. 18, 4, p. 547-551 5 p.

Research output: Contribution to journalArticleResearchpeer-review

132 Citations (Scopus)

GABA production by glutamic acid decarboxylase is regulated by a dynamic catalytic loop

Fenalti, G., Law, R. H. P., Buckle, A. M., Langendorf, C., Tuck, K. L., Rosado, C. J., Faux, N. G., Mahmood, K., Hampe, C. S., Banga, J. P., Wilce, M. C. J., Schmidberger, J., Rossjohn, J., El-Kabbani, O., Pike, R. N., Smith, A. I., Mackay, I. R., Rowley, M. J. & Whisstock, J., 2007, In : Nature Structural and Molecular Biology. 14, 4, p. 280 - 286 7 p.

Research output: Contribution to journalArticleResearchpeer-review

6 Citations (Scopus)

Generation of mutant leukaemia inhibitory factor (LIF)-IgG heavy chain fusion proteins as bivalent antagonists of LIF

Jazayeri, J., De Weerd, N. A., Raye, W. S., Velkov, T., Santos, L. L., Taylor, D. & Carroll, G. J., 2007, In : Journal of Immunological Methods. 323, 1, p. 1 - 10 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Geometric forms of 8-chloro-11-[4-(8-chloro-5H-dibenzo[b,e][1,4]diazepin- 11-yl)piperazin-1-yl]-5H-dibenzo[b,e][1,4]diazepine-acetone-pentane (2/1/1)

Capuano, B., Crosby, I. T., Fallon, G. D., Forsyth, C. M., Lloyd, E. J., Podloucka, A. & Yuriev, E., 2007, In : Acta Crystallographica Section E: Structure Reports Online. 63, 10, p. O4034 - U2899 10 p.

Research output: Contribution to journalArticleResearchpeer-review

55 Citations (Scopus)

Global Changes in Local Protein Dynamics Reduce the Entropic Cost of Carbohydrate Binding in the Arabinose-binding Protein

MacRaild, C. A., Daranas, A. H., Bronowska, A. & Homans, S. W., 4 May 2007, In : Journal of Molecular Biology. 368, 3, p. 822-832 11 p.

Research output: Contribution to journalArticleResearchpeer-review

1 Citation (Scopus)

Lipophilicity of beta-adrenocepter antagonists: A new classification scheme for clinical use

Northfield, S. & Manallack, D. T., 2007, In : Journal of Pharmacy Practice and Research. 37, 2, p. 98 - 101 4 p.

Research output: Contribution to journalArticleResearchpeer-review

66 Citations (Scopus)

Macrophage migration inhibitory factor: A therapeutic target across inflammatory diseases

Hoi, A., Iskander, M. N. & Morand, E. F., 2007, In : Inflammation & Allergy - Drug Targets. 6, 3, p. 183 - 190 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Modelling stem cell properties and fate decisions

Winkler, D., Halley, J. & Burden, F., 2007, In : Drugs of the Future. 32, p. 93 1 p.

Research output: Contribution to journalArticleResearchpeer-review

14 Citations (Scopus)

Molecular characterization of a disease associated conformational epitope on GAD65 recognised by a human monoclonal antibody b96.11

Fenalti, G., Hampe, C. S., O'Connor, K., Banga, J. P., Mackay, I. R., Rowley, M. J. & El-Kabbani, O., 2007, In : Molecular Immunology. 44, 6, p. 1178 - 1189 12 p.

Research output: Contribution to journalArticleResearchpeer-review

53 Citations (Scopus)

New methodology for the N-demethylation of opiate alkaloids

Dong, Z. & Scammells, P. J., 2007, In : Journal of Organic Chemistry. 72, 26, p. 9881 - 9885 5 p.

Research output: Contribution to journalArticleResearchpeer-review

29 Citations (Scopus)

On the stability of 2-aminoselenophene-3-carboxylates: potential dual-acting selenium-containing allosteric enhancers of A1 adenosine receptor binding

Aumann, K. M., Scammells, P. J., Whitehead, J. M. & Schiesser, C. H., 2007, In : Organic and Biomolecular Chemistry. 5, 8, p. 1276 - 1281 6 p.

Research output: Contribution to journalArticleResearchpeer-review

16 Citations (Scopus)

Probing the Flexibility of the DsbA Oxidoreductase from Vibrio cholerae-a 15N - 1H Heteronuclear NMR Relaxation Analysis of Oxidized and Reduced Forms of DsbA

Horne, H. J., d'Auvergne, E. J., Coles, M., Velkov, T., Chin, Y., Charman, W. N., Prankerd, R. J., Gooley, P. & Scanlon, M., 2007, In : Journal of Molecular Biology. 371, 3, p. 703 - 716 14 p.

Research output: Contribution to journalArticleResearchpeer-review

7 Citations (Scopus)

Rat NAD+-dependent 3alpha-hydroxysteroid dehydrogenase (AKR1C17): A member of the aldo-keto reductase family highly expressed in kidney cytosol

Sanai, M., Endo, S., Matsunaga, T., Ishikura, S., Tajima, K., El-Kabbani, O. & Hara, A., 2007, In : Archives of Biochemistry and Biophysics. 464, 1, p. 122 - 129 8 p.

Research output: Contribution to journalArticleResearchpeer-review

59 Citations (Scopus)

Re-discovering PDE3 inhibitors - New opportunities for a long neglected target

Thompson, P., Manganiello, V. & Degerman, E., 2007, In : Current Topics in Medicinal Chemistry. 7, 4, p. 421 - 436 16 p.

Research output: Contribution to journalArticleResearchpeer-review

46 Citations (Scopus)

Selectivity determinants of the aldose and aldehyde reductase inhibitor-binding sites

El-Kabbani, O. & Podjarny, A. D., 2007, In : Cellular and Molecular Life Sciences. 64, 15, p. 1970 - 1978 9 p.

Research output: Contribution to journalArticleResearchpeer-review