Research Output 1977 2019

Filter
Article
2009
25 Citations (Scopus)

RAFT-mediated polymerization of styrene in readily biodegradable ionic liquids

Johnston-Hall, G., Harjani, J. R., Scammells, P. J. & Monteiro, M. J., 2009, In : Macromolecules. 42, 5, p. 1604 - 1609 5 p.

Research output: Contribution to journalArticleResearchpeer-review

7 Citations (Scopus)

Reaction pathways to 2-aminothiophenes and thiophene-3-carbonitriles

Aurelio, L., Flynn, B. L. & Scammells, P. J., 2009, In : Australian Journal of Chemistry. 62, 5, p. 402 - 406 5 p.

Research output: Contribution to journalArticleResearchpeer-review

18 Citations (Scopus)

Structural biology of carbohydrate xenoantigens

Yuriev, E., Agostino, M. J., Farrugia, W., Christiansen, D., Sandrin, M. S. & Ramsland, P. A., 2009, In : Expert Opinion on Biological Therapy. 9, 8, p. 1017 - 1029 13 p.

Research output: Contribution to journalArticleResearchpeer-review

4 Citations (Scopus)

Structure/function analysis of a critical disulfide bond in the active site of l-xylulose reductase

Zhao, H-T., Endo, S., Ishikura, S., Chung, R. P-T., Hogg, P. J., Hara, A. & El-Kabbani, O., 2009, In : Cellular and Molecular Life Sciences. 66, 9, p. 1570 - 1579 10 p.

Research output: Contribution to journalArticleResearchpeer-review

18 Citations (Scopus)

Structure and dynamics of glyceride lipid formulations, with propylene glycol and water

Warren, D., Chalmers, D. K. & Pouton, C. W., 2009, In : Molecular Pharmaceutics. 6, 2, p. 604 - 614 11 p.

Research output: Contribution to journalArticleResearchpeer-review

24 Citations (Scopus)

Structure and function of the oxidoreductase DsbA1 from Neisseria meningitidis

Vivian, J., Scoullar, J., Rimmer, K., Bushell, S. R., Beddoe, T. C., Wilce, M. C. J., Byres, E., Boyle, T. P., Doak, B. C., Simpson, J. S., Graham, B., Heras, B., Kahler, C. M., Rossjohn, J. & Scanlon, M., 2009, In : Journal of Molecular Biology. 394, 5, p. 931 - 943 13 p.

Research output: Contribution to journalArticleResearchpeer-review

22 Citations (Scopus)

Structure-guided design, synthesis, and evaluation of salicylic acid-based inhibitors targeting a selectivity pocket in the active site of human 20alpha-hydroxysteroid dehydrogenase (AKR1C1)

El-Kabbani, O., Scammells, P. J., Gosling, J. I., Dhagat, U., Endo, S., Matsunaga, T., Soda, M. & Hara, A., 2009, In : Journal of Medicinal Chemistry. 52, 10, p. 3259 - 3264 6 p.

Research output: Contribution to journalArticleResearchpeer-review

25 Citations (Scopus)

Structure of granzyme C reveals an unusual mechanism of protease autoinhibition

Kaiserman, D., Buckle, A. M., Van Damme, P., Irving, J. A., Law, R. H. P., Matthews, A. Y., Bashtannyk-Puhalovich, T. A., Langendorf, C., Thompson, P., Vandekerckhove, J., Gevaert, K., Whisstock, J. C. & Bird, P. I., 2009, In : Proceedings of the National Academy of Sciences. 106, 14, p. 5587 - 5592 6 p.

Research output: Contribution to journalArticleResearchpeer-review

2 Citations (Scopus)

Structure of the G225P/G226P mutant of mouse 3(17)alpha-hydroxysteroid dehydrogenase (AKR1C21) ternary complex: Implications for the binding of inhibitor and substrate

Dhagat, U., Endo, S., Mamiya, H., Hara, A. & El-Kabbani, O., 2009, In : Acta Crystallographica Section D: Biological Crystallography. 65, 3, p. 257 - 265 9 p.

Research output: Contribution to journalArticleResearchpeer-review

8 Citations (Scopus)

Synthesis and evaluation of dithiolethiones as novel cyclooxygenase inhibitors

Zanatta, S. D., Manallack, D. T., Jarrott, B. & Williams, S. J., 2009, In : Bioorganic and Medicinal Chemistry Letters. 19, 2, p. 459 - 461 3 p.

Research output: Contribution to journalArticleResearchpeer-review

8 Citations (Scopus)

Synthesis and preliminary screening of novel indole-3-methanamines as 5-HT4 receptor ligands

Hanna-Elias, A., Manallack, D. T., Berque-Bestel, I., Irving, H. R., Coupar, I. M. & Iskander, M. N., 2009, In : European Journal of Medicinal Chemistry. 44, 7, p. 2952 - 2959 8 p.

Research output: Contribution to journalArticleResearchpeer-review

6 Citations (Scopus)

Synthesis of quinoline derivatives as 5-HT4 receptor ligands

Hanna-Elias, A., Manallack, D. T., Berque-Bestel, I., Irving, H. R., Coupar, I. M. & Iskander, M. N., 2009, In : Australian Journal of Chemistry. 62, 2, p. 150 - 156 7 p.

Research output: Contribution to journalArticleResearchpeer-review

38 Citations (Scopus)

The acid-base profile of a contemporary set of drugs: implications for drug discovery

Manallack, D. T., 2009, In : SAR and QSAR in Environmental Research. 20, 7-8, p. 611 - 655 45 p.

Research output: Contribution to journalArticleResearchpeer-review

14 Citations (Scopus)

The effects of exosite occupancy on the substrate specificity of thrombin

Ng, N. M-Y., Quinsey, N. S., Matthews, A. Y., Kaiserman, D., Wijeyewickrema, L. C., Bird, P. I., Thompson, P. E. & Pike, R. N., 2009, In : Archives of Biochemistry and Biophysics. 489, 1-2, p. 48 - 54 7 p.

Research output: Contribution to journalArticleResearchpeer-review

10 Citations (Scopus)

The identification and optimisation of novel and selective diamide neuropeptide Y Y2 receptor antagonists

Lunniss, G. E., Barnes, A. A., Barton, N., Biagetti, M., Bianchi, F., Blowers, S. M., Caberlotto, L., Emmons, A., Holmes, I. P., Montanari, D., Norris, R., Walters, D. J. & Watson, S. P., 2009, In : Bioorganic and Medicinal Chemistry Letters. 19, 15, p. 4022 - 4025 4 p.

Research output: Contribution to journalArticleResearchpeer-review

12 Citations (Scopus)

The identification of beta-hydroxy carboxylic acids as selective MMP-12 inhibitors.

Holmes, I. P., Gaines, S., Watson, S. P., Lorthioir, O., Walker, A., Baddeley, S. J., Herbert, S., Egan, D., Convery, M. A., Singh, O. M. P., Gross, J. W., Strelow, J. M., Smith, R. H., Amour, A. J., Brown, D. & Stephen, M. L., 2009, In : Bioorganic and Medicinal Chemistry Letters. 19, 19, p. 5760 - 5763 4 p.

Research output: Contribution to journalArticleResearchpeer-review

12 Citations (Scopus)

Thermodynamics of lipophilic drug binding to intestinal fatty acid binding protein and permeation across membranes

Velkov, T., 6 Apr 2009, In : Molecular Pharmaceutics. 6, 2, p. 557-570 14 p.

Research output: Contribution to journalArticleResearchpeer-review

41 Citations (Scopus)

The Structure of the Bacterial Oxidoreductase Enzyme DsbA in Complex with a Peptide Reveals a Basis for Substrate Specificity in the Catalytic Cycle of DsbA Enzymes

Paxman, J. J., Borg, N., Horne, H. J., Thompson, P., Chin, K. Y., Sharma, P., Simpson, J. S., Wielens, J., Piek, S., Kahler, C. M., Sakellaris, H., Pearce, M. C., Bottomley, S. P., Rossjohn, J. & Scanlon, M., 2009, In : Journal of Biological Chemistry. 284, 26, p. 17835 - 17845 11 p.

Research output: Contribution to journalArticleResearchpeer-review

1 Citation (Scopus)

The Use of Tripeptides for Lead Discovery of 5-HT4 Receptor Ligands

Hanna-Elias, A., Thompson, P., Manallack, D. T., Irving, H. R., Coupar, I. M., Berque-Bestel, I. & Iskander, M. N., 2009, In : Protein and Peptide Letters. 16, 7, p. 805 - 809 5 p.

Research output: Contribution to journalArticleResearchpeer-review

60 Citations (Scopus)

Total Synthesis of the Potent Anticancer Aglaia Metabolites (-)-Silvestrol and (-)-Episilvestrol and the Active Analogue (-)-4-Desmethoxyepisilvestrol

Adams, T. E., El Sous, M., Hawkins, B. C., Hirner, S., Holloway, G. A., Khoo, M. L., Owen, D. J., Savage, G. P., Scammells, P. J. & Rizzacasa, M. A., 2009, In : Journal of the American Chemical Society. 131, 4, p. 1607 - 1616 10 p.

Research output: Contribution to journalArticleResearchpeer-review

2008
38 Citations (Scopus)

2-Aminothienopyridazines as novel adenosine A1 receptor allosteric modulators and antagonists

Ferguson, G. N., Valant, C., Horne, H. J., Figler, H., Flynn, B. L., Linden, J., Chalmers, D. K., Sexton, P., Christopoulos, A. & Scammells, P. J., 2008, In : Journal of Medicinal Chemistry. 51, 19, p. 6165 - 6172 8 p.

Research output: Contribution to journalArticleResearchpeer-review

45 Citations (Scopus)

5-Substituted 2-aminothiophenes as A1 adenosine receptor allosteric enhancers

Aurelio, L., Figler, H., Flynn, B. L., Linden, J. & Scammells, P. J., 2008, In : Bioorganic & Medicinal Chemistry. 16, 3, p. 1319 - 1327 9 p.

Research output: Contribution to journalArticleResearchpeer-review

1 Citation (Scopus)

8-Chloro-5-(4-phenethylpiperazin-1 - Yl)pyrido[2,3-b][1,5]benzoxazepine

Capuano, B., Crosby, I. T., Forsyth, C. M., Lloyd, E. J., Vom, A. & Yuriev, E., 2008, In : Acta Crystallographica Section E: Structure Reports Online. 64, Part 10, p. O1865 - O1866 1 p.

Research output: Contribution to journalArticleResearchpeer-review

13 Citations (Scopus)

A concise approach to the polycyclic scaffold of frondosin D

Masters, K-S. & Flynn, B. L., 2008, In : Journal of Organic Chemistry. 73, 20, p. 8081 - 8084 4 p.

Research output: Contribution to journalArticleResearchpeer-review

26 Citations (Scopus)

A double mutation of MBP83-99 peptide induces IL-4 responses and antagonizes IFN-gamma responses

Katsara, M., Yuriev, E., Ramsland, P. A., Deraos, G., Tselios, T., Matsoukas, J. & Apostolopoulos, V., 2008, In : Journal of Neuroimmunology. 200, 1-2, p. 77 - 89 13 p.

Research output: Contribution to journalArticleResearchpeer-review

58 Citations (Scopus)

Alternating lodonium-mediated reaction cascades giving indole- And quinoline-containing polycycles

Halim, R., Scammells, P. J. & Flynn, B. L., 2008, In : Organic Letters. 10, 10, p. 1967 - 1970 4 p.

Research output: Contribution to journalArticleResearchpeer-review

5 Citations (Scopus)

Aminimides as potential CNS acting agents. II design, synthesis, and receptor binding of 4'-arylalkyl aminimide analogues of clozapine as prospective novel antipsychotics

Capuano, B., Crosby, I. T., Lloyd, E. J., Neve, J. E. & Taylor, D., 2008, In : Australian Journal of Chemistry. 61, 1, p. 5 - 10 6 p.

Research output: Contribution to journalArticleResearchpeer-review

4 Citations (Scopus)

Aminimides as potential CNS-acting agents. III. Design, synthesis, and receptor binding of aminimide analogues of dopamine, serotonin, morphine, and nicotine

Capuano, B., Crosby, I. T., Lloyd, E. J., Neve, J. E. & Taylor, D., 2008, In : Australian Journal of Chemistry. 61, 6, p. 422 - 431 10 p.

Research output: Contribution to journalArticleResearchpeer-review

11 Citations (Scopus)

An efficient convergent synthesis of adenosine-5'-N-alkyluronamides

Devine, S. & Scammells, P. J., 2008, In : Tetrahedron. 64, 8, p. 1772 - 1777 6 p.

Research output: Contribution to journalArticleResearchpeer-review

41 Citations (Scopus)

An Efficient Synthesis and Substitution of 3-Aroyl-2-bromobenzo[b]furans

Gurmit, G. S., Grobelny, D., Chaplin, J. H. & Flynn, B. L., 2008, In : Journal of Organic Chemistry. 73, 3, p. 1131 - 1134 4 p.

Research output: Contribution to journalArticleResearchpeer-review

129 Citations (Scopus)
15 Citations (Scopus)

Antibody-ligand docking: insights into peptide-carbohydrate mimicry

Yuriev, E., Sandrin, M. S. & Ramsland, P. A., 2008, In : Molecular Simulation. 34, 4, p. 461 - 468 8 p.

Research output: Contribution to journalArticleResearchpeer-review

18 Citations (Scopus)

Antiviral agents. I. Synthesis and antiviral evaluation of trimeric naphthoquinone analogues of conocurvone

Crosby, I. T., Rose, M. L., Collis, M., De Bruyn, P. J., Keep, P. L. & Robertson, A. D., 2008, In : Australian Journal of Chemistry. 61, 10, p. 768 - 784 17 p.

Research output: Contribution to journalArticleResearchpeer-review

8 Citations (Scopus)

A protocol for the combined sub-fractionation and delipidation of lipid binding proteins using hydrophobic interaction chromatography

Velkov, T., Lim, M. L. R., Capuano, B. & Prankerd, R. J., 2008, In : Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences. 867, 2, p. 238 - 246 9 p.

Research output: Contribution to journalArticleResearchpeer-review

2 Citations (Scopus)

Backbone assignments of the 34kDa ketopantoate reductase from E. coli

Headey, S. J., Vom, A., Simpson, J. S. & Scanlon, M., 2008, In : Biomolecular NMR Assignments. 2, 1, p. 93 - 96 4 p.

Research output: Contribution to journalArticleResearchpeer-review

52 Citations (Scopus)

Carboxymethylated pyridoindole antioxidants as aldose reductase inhibitors: Synthesis, activity, partitioning, and molecular modeling

Stefek, M., Snirc, V., Djoubissie, P-O., Majekova, M., Demopoulos, V., Rackova, L., Bezakova, Z., Karasu, C., Carbone, V. & El-Kabbani, O., 2008, In : Bioorganic & Medicinal Chemistry. 16, 9, p. 4908 - 4920 13 p.

Research output: Contribution to journalArticleResearchpeer-review

53 Citations (Scopus)

Characterization of the drug binding specificity of rat liver fatty acid binding protein

Chuang, S., Velkov, T., Horne, J., Porter, C. J. & Scanlon, M., 2008, In : Journal of Medicinal Chemistry. 51, 13, p. 3755 - 3764 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Chemistry is complex

Winkler, D. A., 2008, In : Chemistry in Australia. 75, 5, p. 4 1 p.

Research output: Contribution to journalArticleResearchpeer-review

3 Citations (Scopus)

Computer-assisted design of cyclic peptides and peptidomimetics

Camerino, M. A., Chalmers, D. K. & Thompson, P., 2008, In : Chimica Oggi. 26, 5, p. 46 - 51 6 p.

Research output: Contribution to journalArticleResearchpeer-review

37 Citations (Scopus)

Dissecting isoform selectivity of P13K inhibitors: The role of non-conserved residues in the catalytic pocket

Frazzetto, M., Suphioglu, C., Zhu, J., Schmidt-Kittler, O., Jennings, I., Cranmer, S. L., Jackson, S., Kinzler, K., Vogelstein, B. & Thompson, P., 2008, In : Biochemical Journal. 414, 3, p. 383 - 390 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Folate Biosynthesis - Reappraisal of Old and Novel Targets in the Search for New Antimicrobials

Swarbrick, J. D., Iliades, P., Simpson, J. S. & Macreadie, I., 2008, In : The Open Enzyme Inhibition Journal. 1, 0, p. 12 - 33 22 p.

Research output: Contribution to journalArticleResearchpeer-review

29 Citations (Scopus)

Human carbonyl reductase 4 is a mitochondrial NADPH-dependent quinone reductase

Endo, S., Matsunaga, T., Kitade, Y., Ohno, S., Tajima, K., El-Kabbani, O. & Hara, A., 2008, In : Biochemical and Biophysical Research Communications. 377, 4, p. 1326 - 1330 5 p.

Research output: Contribution to journalArticleResearchpeer-review

9 Citations (Scopus)

Inhibition of 3(17)alpha-hydroxysteroid dehydrogenase (AKR1C21) by aldose reductase inhibitors

Dhagat, U., Endo, S., Hara, A. & El-Kabbani, O., 2008, In : Bioorganic & Medicinal Chemistry. 16, 6, p. 3245 - 3254 10 p.

Research output: Contribution to journalArticleResearchpeer-review

24 Citations (Scopus)

Mannosylation of mutated MBP83-99 peptides diverts immune responses from Th1 to Th2

Katsara, M., Yuriev, E., Ramsland, P. A., Deraos, G., Tselios, T., Matsoukas, J. & Apostolopoulos, V., 2008, In : Molecular Immunology. 45, 13, p. 3661 - 3670 10 p.

Research output: Contribution to journalArticleResearchpeer-review

9 Citations (Scopus)

MHC and MHC-like molecules: Structural perspectives on the design of molecular vaccines

Apostolopoulos, V., Yuriev, E., Lazoura, E., Yu, M. & Ramsland, P. A., 2008, In : Human Vaccines. 640, 6, p. 252 - 267 15 p.

Research output: Contribution to journalArticleResearchpeer-review

11 Citations (Scopus)

Microwave-assisted direct amination: Rapid access to multi-functionalized N6-substituted adenosines

Ashton, T. D. & Scammells, P. J., 2008, In : Australian Journal of Chemistry. 61, 1, p. 49 - 58 10 p.

Research output: Contribution to journalArticleResearchpeer-review

21 Citations (Scopus)

N6-substituted C5'-modified adenosines as A1 adenosine receptor agonists

Ashton, T. D., Baker, S. P., Hutchinson, S. A. & Scammells, P. J., 2008, In : Bioorganic & Medicinal Chemistry. 16, 4, p. 1861 - 1873 13 p.

Research output: Contribution to journalArticleResearchpeer-review

8 Citations (Scopus)

Network models in drug discovery and regenerative medicine

Winkler, D. A., 2008, In : Biotechnology Annual Review. 14, p. 143-170 28 p.

Research output: Contribution to journalArticleOther

1 Citation (Scopus)

Ni2+-Based Immobilized Metal Ion Affinity Chromatography of Lactose Operon Repressor Protein from Escherichia Coli

Velkov, T., Jones, A. & Lim, M. L. R., 2008, In : Preparative Biochemistry & Biotechnology. 38, 4, p. 422 - 441 20 p.

Research output: Contribution to journalArticleResearchpeer-review

36 Citations (Scopus)

Plantensimycin: A promising antimicrobial targeting fatty acid synthesis

Manallack, D. T., Crosby, I. T., Khakham, Y. & Capuano, B., 2008, In : Current Medicinal Chemistry. 15, 7, p. 705 - 710 6 p.

Research output: Contribution to journalArticleResearchpeer-review