Research Output 1977 2019

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2010

Studies on a Tyr residue critical for the binding of coenzyme and substrate in mouse 3(17)alpha-hydroxysteroid dehydrogenase (AKR1C21): Structure of the Y224D mutant enzyme

Dhagat, U., Endo, S., Mamiya, H., Hara, A. & El-Kabbani, O., 2010, In : Acta Crystallographica Section D: Biological Crystallography. 66, 2, p. 198 - 204 7 p.

Research output: Contribution to journalArticleResearchpeer-review

1 Citation (Scopus)

Synthesis, testing and structure-activity studies on a library of 5-HT 4 ligands

Hanna-Elias, A., Manallack, D. T., Levit, A., Nguyen, W., Ayad, F., Perera, G., Shapiro, M., Coupar, I. M., Iskander, M. N. & Irving, H. R., 2010, In : Medicinal Chemistry. 6, 6, p. 344 - 354 11 p.

Research output: Contribution to journalArticleResearchpeer-review

10 Citations (Scopus)

Synthesis and evaluation of new N6-substituted adenosine-5'-N-methylcarboxamides as A3 adenosine receptor agonists

Devine, S. M., Gregg, A., Figler, H., McIntosh, K., Urmaliya, V., Linden, J., Pouton, C. W., White, P. J., Bottle, S. E. & Scammells, P. J., 2010, In : Bioorganic and Medicinal Chemistry Letters. 18, 9, p. 3078 - 3087 10 p.

Research output: Contribution to journalArticleResearchpeer-review

2 Citations (Scopus)

Synthesis and preliminary screening of novel tryptamines as 5-HT4 receptor ligands

Hanna-Elias, A., Manallack, D., Berque-Bestel, I., Irving, H., Coupar, I. & Iskander, M., 2010, In : Current Medicinal Chemistry. 17, p. 2775 - 2787 13 p.

Research output: Contribution to journalArticleResearchpeer-review

6 Citations (Scopus)

Synthesis of "difficult" fluorescence quenched substrates of granzyme C

Northfield, S., Roberts, K., Mountford, S., Hughes, R., Kaiserman, D., Mangan, M., Pike, R., Bird, P. & Thompson, P., 2010, In : International Journal of Peptide Research and Therapeutics. 16, p. 159 - 165 7 p.

Research output: Contribution to journalArticleResearchpeer-review

10 Citations (Scopus)

The application of the Schmidt reaction and Beckmann rearrangement to the synthesis of bicyclic lactams: some mechanistic considerations

Crosby, I., Shin, J. & Capuano, B., 2010, In : Australian Journal of Chemistry. 63, 2, p. 211 - 226 16 p.

Research output: Contribution to journalArticleResearchpeer-review

5 Citations (Scopus)

The identification of a selective dopamine D2 partial agonist, D3 antagonist displaying high levels of brain exposure

Holmes, I. P., Blunt, R. J., Lorthoir, O. E., Blowers, S. M., Gribble, A., Payne, A. H., Stansfield, I. G., Wood, M. D., Woollard, P. M., Reavill, C., Howes, C. M., Micheli, F., Di Fabio, R., Donati, D., Terreni, S., Hamprecht, D., Arista, L., Worby, A. & Watson, S. P., 2010, In : Bioorganic and Medicinal Chemistry Letters. 20, 6, p. 2013 - 2016 4 p.

Research output: Contribution to journalArticleResearchpeer-review

2 Citations (Scopus)

The synthesis and preliminary pharmacological evaluation of a series of substituted 4-phenoxypropyl analogues of the atypical antipsychotic clozapine

Capuano, B., Crosby, I. T., McRobb, F. M., Podloucka, A., Taylor, D. A., Vom, A. & Yuriev, E., 2010, In : Australian Journal of Chemistry. 63, 1, p. 116 - 124 9 p.

Research output: Contribution to journalArticleResearchpeer-review

29 Citations (Scopus)

Two-step iron(0)-mediated N-demethylation of N -methyl alkaloids

Kok, G. B. B., Pye, C. C., Singer, R. D. & Scammells, P. J., 2010, In : Journal of Organic Chemistry. 75, 14, p. 4806 - 4811 6 p.

Research output: Contribution to journalArticleResearchpeer-review

14 Citations (Scopus)

Use of Kv1.3 blockers for inflammatory skin conditions

Nguyen, W., Neale, D., Howard, B., Thompson, P., White, P., Wulff, H. & Manallack, D., 2010, In : Current Medicinal Chemistry. 17, 26, p. 2882 - 2896 15 p.

Research output: Contribution to journalArticleResearchpeer-review

6 Citations (Scopus)

Using the beta2-adrenoceptor for structure-based drug design

Manallack, D. T., Chalmers, D. K. & Yuriev, E., 2010, In : Journal of Chemical Education. 87, 6, p. 625 - 627 3 p.

Research output: Contribution to journalArticleResearchpeer-review

4 Citations (Scopus)

Zinc is not required for activity of TPO agonists acting at the c-Mpl receptor transmembrane domain

Andrade, J., Cablewski, T., Condie, G., Haylock, D. N., Meagher, L., Riches, A. G., Tarasova, A., Werkmeister, J. A., White, J. & Winkler, D. A., 2010, In : ACS Chemical Biology. 5, 8, p. 741-745 5 p.

Research output: Contribution to journalArticleResearchpeer-review

2009
1 Citation (Scopus)

2,2,7-Trichloro-3,4-dihydronaphthalen-1(2H)-one

Capuano, B., Crosby, I. T., Forsyth, C. M. & Shin, J. K., 2009, In : Acta Crystallographica Section E: Structure Reports Online. 65, Part 9, p. 02254 - 02254 1 p.

Research output: Contribution to journalArticleResearchpeer-review

26 Citations (Scopus)

3- and 6-substituted 2-amino-4,5,6,7-tetrahydrothieno[2,3-c]pyridines as A1 adenosine receptor allosteric modulators and antagonists

Aurelio, L., Valant, C., Figler, H., Flynn, B. L., Linden, J., Sexton, P., Christopoulos, A. & Scammells, P. J., 2009, In : Bioorganic & Medicinal Chemistry. 17, 20, p. 7353 - 7361 9 p.

Research output: Contribution to journalArticleResearchpeer-review

86 Citations (Scopus)
27 Citations (Scopus)

Altered peptide ligands of myelin basic protein (MBP87-99) conjugated to reduced mannan modulate immune responses in mice

Katsara, M., Yuriev, E., Ramsland, P. A., Tselios, T., Deraos, G., Lourbopoulos, A., Grigoriadis, N., Matsoukas, J. & Apostolopoulos, V., 2009, In : Immunology. 128, 4, p. 521 - 533 13 p.

Research output: Contribution to journalArticleResearchpeer-review

10 Citations (Scopus)

Alternation of Chemoselective Control in Stille-Heck and Heck-Stille Reaction Sequences

Masters, K-S. & Flynn, B. L., 2009, In : Advanced Synthesis and Catalysis. 351, 4, p. 530 - 536 7 p.

Research output: Contribution to journalArticleResearchpeer-review

1 Citation (Scopus)

An evaluation of the modified 6-31G* basis set for the atoms Ga-Kr using the Gaussian-3 and Gaussian-4 composite methods

Duke, B. J., Jan 2009, In : Molecular Physics. 107, 8-12, p. 1027-1034 8 p.

Research output: Contribution to journalArticleResearchpeer-review

29 Citations (Scopus)

An Improved Process for the N-Demethylation of Opiate Alkaloids using an Iron(II) Catalyst in Acetate Buffer

Orbell, G. B., Ashton, T. D. & Scammells, P. J., 2009, In : Advanced Synthesis and Catalysis. 351, 1-2, p. 283 - 286 4 p.

Research output: Contribution to journalArticleResearchpeer-review

13 Citations (Scopus)

Binding of HIV-1 TAR mRNA to a peptide nucleic acid oligomer and its conjugates with metal-ion-binding multidentate ligands

Belousoff, M. J., Gasser, G. A., Graham, B., Tor, Y. & Spiccia, L., 2009, In : Journal of Biological Inorganic Chemistry. 14, p. 287 - 300 14 p.

Research output: Contribution to journalArticleResearchpeer-review

104 Citations (Scopus)

Biodegradable pyridinium ionic liquids: design, synthesis and evaluation

Harjani, J. R., Singer, R. D., Garcia, M. T. & Scammells, P. J., 2009, In : Green Chemistry. 11, 1, p. 83 - 90 8 p.

Research output: Contribution to journalArticleResearchpeer-review

22 Citations (Scopus)

Characterization of a rat NADPH-dependent aldo-keto reductase (AKR1B13) induced by oxidative stress

Endo, S., Matsunaga, T., Mamiya, H., Hara, A., Kitade, Y., Tajima, K. & El-Kabbani, O., 2009, In : Chemico-Biological Interactions. 178, 1-3, p. 151 - 157 7 p.

Research output: Contribution to journalArticleResearchpeer-review

16 Citations (Scopus)

Characterization of lipophilic drug binding to rat intestinal fatty acid binding protein

Velkov, T., Hughes, M. L. R., Horne, H. J., Simpson, J. S., Porter, C. J. & Scanlon, M., 2009, In : Molecular and Cellular Biochemistry. 326, 1-2, p. 87 - 95 9 p.

Research output: Contribution to journalArticleResearchpeer-review

23 Citations (Scopus)

Cleavage of RNA oligonucleotides by aminoglycosides

Belousoff, M. J., Graham, B., Spiccia, L. & Tor, Y., 2009, In : Organic and Biomolecular Chemistry. 7, p. 30 - 33 4 p.

Research output: Contribution to journalArticleResearchpeer-review

13 Citations (Scopus)

Conformational Analysis of Drug Molecules: A Practical Exercise in the Medicinal Chemistry Course

Yuriev, E., Chalmers, D. K. & Capuano, B., 2009, In : Journal of Chemical Education. 86, 4, p. 477 - 478 2 p.

Research output: Contribution to journalArticleResearchpeer-review

16 Citations (Scopus)

Correlation of binding constants and molecular modelling of inhibitors in the active sites of aldose reductase and aldehyde reductase

Carbone, V., Zhao, H-T., Chung, R. P-T., Endo, S., Hara, A. & El-Kabbani, O., 2009, In : Bioorganic & Medicinal Chemistry. 17, 3, p. 1244 - 1250 7 p.

Research output: Contribution to journalArticleResearchpeer-review

3 Citations (Scopus)

Crystallization and preliminary X-ray analysis of a rat aldose reductase-like protein (AKR1B14)

Chung, R. P-T., Endo, S., Hara, A. & El-Kabbani, O., 2009, In : Acta Crystallographica. Section F: Structural Biology Communications. 65, Pt 4, p. 395 - 397 3 p.

Research output: Contribution to journalArticleResearchpeer-review

5 Citations (Scopus)

Discovery of inhibitors of lupin diadenosine 5',5'''-P1,P4-tetraphosphate hydrolase by virtual screening

Branson, K. M., Mertens, H. D., Swarbrick, J. D., Fletcher, J. I., Kedzierski, L., Gayler, K. R., Gooley, P. R. & Smith, B. J., 2009, In : Biochemistry. 48, 32, p. 7614 - 7620 7 p.

Research output: Contribution to journalArticleResearchpeer-review

1 Citation (Scopus)

Di-tert-butyl N-[2,6-bis(methoxymethoxy)phenyl]iminodiacetate

Capuano, B., Crosby, I. T., Forsyth, C. M., Khakham, Y. & Manallack, D. T., 2009, In : Acta Crystallographica Section E: Structure Reports Online. 65, 819, p. 1 - 10 10 p.

Research output: Contribution to journalArticleResearchpeer-review

18 Citations (Scopus)

Dopamine D3 receptor antagonists: The quest for a potentially selective PET ligand. Part 3: Radiosynthesis and in vivo studies

Bennacef, I., Salinas, C. A., Bonasera, T. A., Gunn, R. N., Audrain, H., Jakobsen, S., Nabulsi, N., Weinzimmer, D., Carson, R. E., Huang, Y., Holmes, I. P., Micheli, F., Heidbreder, C., Gentile, G., Rossi, T. & Laruelle, M., 2009, In : Bioorganic and Medicinal Chemistry Letters. 19, 17, p. 5056 - 5059 4 p.

Research output: Contribution to journalArticleResearchpeer-review

7 Citations (Scopus)

Dopamine D3 receptor antagonists: The quest for a potentially selective PET ligand. Part one: Lead identification

Holmes, I. P., Micheli, F., Gaines, S., Lorthoir, O. E., Watson, S. P., Di Fabio, R., Gentile, G., Heidbreder, C., Savoia, C. & Worby, A., 2009, In : Bioorganic and Medicinal Chemistry Letters. 19, 16, p. 4799 - 4801 3 p.

Research output: Contribution to journalArticleResearchpeer-review

10 Citations (Scopus)

Dopamine D3 receptor antagonists: The quest for a potentially selective PET ligand. Part two: Lead optimization

Micheli, F., Holmes, I. P., Arista, L., Bonanomi, G., Braggio, S., Cardullo, F., Di Fabio, R., Donati, D., Gentile, G., Hamprecht, D., Terreni, S., Heidbreder, C., Savoia, C., Griffante, C. & Worby, A., 2009, In : Bioorganic and Medicinal Chemistry Letters. 19, 15, p. 4011 - 4013 3 p.

Research output: Contribution to journalArticleResearchpeer-review

179 Citations (Scopus)

DSB proteins and bacterial pathogenicity

Heras, B., Shouldice, S. R., Totsika, M., Scanlon, M., Schembri, M. A. & Martin, J. L., 2009, In : Nature Reviews Microbiology. 7, 13, p. 215 - 225 11 p.

Research output: Contribution to journalArticleResearchpeer-review

83 Citations (Scopus)

Further investigation of the biodegradability of imidazolium ionic liquids

Harjani, J. R., Farrell, J., Garcia, M. T., Singer, R. D. & Scammells, P. J., 2009, In : Green Chemistry. 11, 6, p. 821 - 829 9 p.

Research output: Contribution to journalArticleResearchpeer-review

1 Citation (Scopus)

Gas phase supramolecular cluster ions of deoxyguanosine induced by binding to (2,2':6'2''-terpyridine)-platinum(II) and (diethylenetriamine)-platinum(II)

Khairallah, G. N., Stewart, M. B., Yuriev, E., Xu, Y., Orbell, J. D. & O'Hair, R. A. J., 2009, In : Dalton Transactions. 2009, 9, p. 1542 - 1548 7 p.

Research output: Contribution to journalArticleResearchpeer-review

27 Citations (Scopus)

In silico analysis of antibody-carbohydrate interactions and its application to xenoreactive antibodies

Agostino, M. J., Sandrin, M. S., Thompson, P., Yuriev, E. & Ramsland, P. A., 2009, In : Molecular Immunology. 47, 2-3, p. 233 - 246 14 p.

Research output: Contribution to journalArticleResearchpeer-review

29 Citations (Scopus)

Involvement of an aldo-keto reductase (AKR1C3) in redox cycling of 9,10-phenanthrenequinone leading to apoptosis in human endothelial cells

Matsunaga, T., Arakaki, M., Kamiya, T., Endo, S., El-Kabbani, O. & Hara, A., 2009, In : Chemico-Biological Interactions. 181, 1, p. 52 - 60 9 p.

Research output: Contribution to journalArticleResearchpeer-review

76 Citations (Scopus)

Kinetic studies of AKR1B10, human aldose reductase-like protein: Endogenous substrates and inhibition by steroids

Endo, S., Matsunaga, T., Mamiya, H., Ohta, C., Soda, M., Kitade, Y., Tajima, K., Zhao, H-T., El-Kabbani, O. & Hara, A., 2009, In : Archives of Biochemistry and Biophysics. 487, 1, p. 1 - 9 9 p.

Research output: Contribution to journalArticleResearchpeer-review

10 Citations (Scopus)

Linear and convergent approaches to 2-substituted adenosine-5 '-N-alkylcarboxamides

Foitzik, R., Devine, S., Hausler, N. E. & Scammells, P. J., 2009, In : Tetrahedron. 65, 43, p. 8851 - 8857 7 p.

Research output: Contribution to journalArticleResearchpeer-review

12 Citations (Scopus)

Molecular determinants for the stereospecific reduction of 3-ketosteroids and reactivity towards all-trans-retinal of a short-chain dehydrogenase/reductase (DHRS4)

Endo, S., Maeda, S., Matsunaga, T., Dhagat, U., El-Kabbani, O., Tanaka, N., Nakamura, K. T., Tajima, K. & Hara, A., 2009, In : Archives of Biochemistry and Biophysics. 481, 2, p. 183 - 190 8 p.

Research output: Contribution to journalArticleResearchpeer-review

53 Citations (Scopus)

Molecular docking of carbohydrate ligands to antibodies: Structural validation against crystal structures

Agostino, M. J., Jene, C., Boyle, T. P., Ramsland, P. A. & Yuriev, E., 2009, In : Journal of Chemical Information and Modeling. 49, 12, p. 2749 - 2760 12 p.

Research output: Contribution to journalArticleResearchpeer-review

24 Citations (Scopus)

Molecular Dynamics of Poly(L-lysine) Dendrimers with Naphthalene Disulfonate Caps

Roberts, B. P., Scanlon, M., Krippner, G. Y. & Chalmers, D. K., 2009, In : Macromolecules. 42, 7, p. 2775 - 2783 9 p.

Research output: Contribution to journalArticleResearchpeer-review

18 Citations (Scopus)

Molecular dynamics of variegated polyamide dendrimers

Roberts, B. P., Krippner, G. Y., Scanlon, M. & Chalmers, D. K., 2009, In : Macromolecules. 42, 7, p. 2784 - 2794 11 p.

Research output: Contribution to journalArticleResearchpeer-review

23 Citations (Scopus)

New macrocyclic terbium(III) complex for use in RNA footprinting experiments

Belousoff, M. J., Ung, P., Forsyth, C. M., Tor, Y., Spiccia, L. & Graham, B., 2009, In : Journal of the American Chemical Society. 131, p. 1106 - 1114 9 p.

Research output: Contribution to journalArticleResearchpeer-review

2 Citations (Scopus)

NMR assignment of prespore specific antigen-a cell surface adhesion glycoprotein from Dictyostelium discoideum

Swarbrick, J. D., Cubeddu, L., Ball, G. E., Curmi, P. MG., Gooley, A. A., Williams, K. L. & Mabbutt, B., 2009, In : Biomolecular NMR Assignments. 3, 1, p. 1 - 3 3 p.

Research output: Contribution to journalArticleResearchpeer-review

Novel thrombopoietin mimics for haemopoietic stem cell expansion

Haylock, DN., Andrade, J., White, J., Nilsson, SK., Meagher, L., Cableswki, T., Schwab, K., Tarasova, A., Condie, G., Riches, A. & Winkler, D. A., 2009, In : Experimental Hematology. 37, 9 Suppl 1

Research output: Contribution to journalArticleResearchpeer-review

82 Citations (Scopus)

Phosphonium ionic liquids: design, synthesis and evaluation of biodegradability

Atefi, F., Garcia, M. T., Singer, R. D. & Scammells, P. J., 2009, In : Green Chemistry. 11, 10, p. 1595 - 1604 10 p.

Research output: Contribution to journalArticleResearchpeer-review

47 Citations (Scopus)

Potent and selective inhibition of the tumor marker AKR1B10 by bisdemethoxycurcumin: Probing the active site of the enzyme with molecular modeling and site-directed mutagenesis

Matsunaga, T., Endo, S., Soda, M., Zhao, H-T., El-Kabbani, O., Tajima, K. & Hara, A., 2009, In : Biochemical and Biophysical Research Communications. 389, 1, p. 128 - 132 5 p.

Research output: Contribution to journalArticleResearchpeer-review

5 Citations (Scopus)

Predictive mesoscale network model of cell fate decisions during C. elegans embryogenesis

Winkler, D. A., Burden, F. R. & Halley, J. D., 2009, In : Artificial Life. 15, 4, p. 411-421 11 p.

Research output: Contribution to journalArticleResearchpeer-review