Research Output 1977 2019

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2011
8 Citations (Scopus)

Characterization of the N-methyltransferase activities of the multifunctional polypeptide cyclosporin synthetase

Velkov, T., Horne, J., Scanlon, M., Capuano, B., Yuriev, E. & Lawen, A., 2011, In : Chemistry and Biology. 18, 4, p. 464 - 475 12 p.

Research output: Contribution to journalArticleResearchpeer-review

4 Citations (Scopus)

Commercially supplied amine-modified siRNAs may require ultrafiltration prior to conjugation with amine-reactive compounds

Lau, S., Graham, B., Boyd, B., Pouton, C. & White, P., 2011, In : Journal of Nucleic Acids. 2011, 154609, p. 1 - 5 5 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
29 Citations (Scopus)

Design, synthesis, and evaluation of a new fluorescent probe for measuring polymyxin-lipopolysaccharide binding interactions

Soon, R., Velkov, T., Chiu, F., Thompson, P., Kancharla, R., Roberts, K., Larson, I., Nation, R. & Li, J., 2011, In : Analytical Biochemistry. 409, 2, p. 273 - 283 11 p.

Research output: Contribution to journalArticleResearchpeer-review

63 Citations (Scopus)

Design strategies for bivalent ligands targeting GPCRs

Shonberg, J., Scammells, P. & Capuano, B., 2011, In : ChemMedChem. 6, 6, p. 963 - 974 12 p.

Research output: Contribution to journalArticleResearchpeer-review

99 Citations (Scopus)

Discovery of 7-hydroxy-6-methoxy-2-methyl-3-(3,4,5-trimethoxybenzoyl)benzo[b]furan (BNC105), a tubulin polymerization inhibitor with potent antiproliferative and tumor vascular disrupting properties

Flynn, B., Gurmit, G., Grobelny, D., Chaplin, J., Paul, D., Leske, A., Lavranos, T., Chalmers, D., Charman, S., Kostewicz, E., Shackleford, D., Morizzi, J., Hamel, E., Jung, K. & Kremmidiotis, G., 2011, In : Journal of Medicinal Chemistry. 54, 17, p. 6014 - 6027 14 p.

Research output: Contribution to journalArticleResearchpeer-review

78 Citations (Scopus)

DOTA-amide lanthanide tag for reliable generation of pseudocontact shifts in protein NMR spectra

Graham, B., Loh, C., Swarbrick, J., Ung, P., Shin, J., Yagi, H., Jia, X., Chhabra, S., Barlow, N., Pintacuda, G., Huber, T. & Otting, G., 2011, In : Bioconjugate Chemistry. 22, 10, p. 2118 - 2125 8 p.

Research output: Contribution to journalArticleResearchpeer-review

21 Citations (Scopus)

Edaravone containing isoindoline nitroxides for the potential treatment of cardiovascular ischaemia

Walker, J., Fairfull-Smith, K., Anzai, K., Lau, S., White, P., Scammells, P. & Bottle, S. E., 2011, In : MedChemComm. 2, 5, p. 436 - 441 6 p.

Research output: Contribution to journalArticleResearchpeer-review

8 Citations (Scopus)

Efficient iron-catalyzed n-demethylation of tertiary mmine-n-oxides under oxidative conditions

Orbell, G. & Scammells, P., 2011, In : Australian Journal of Chemistry. 64, 11, p. 1515 - 1521 7 p.

Research output: Contribution to journalArticleResearchpeer-review

101 Citations (Scopus)

Efficient plasmid DNA cleavage by copper(II) complexes of 1,4,7-triazacyclononane ligands featuring Xylyl-linked guanidinium groups

Tjioe, L., Meininger, A., Joshi, T., Spiccia, L. & Graham, B., 2011, In : Inorganic Chemistry. 50, 10, p. 4327 - 4339 13 p.

Research output: Contribution to journalArticleResearchpeer-review

31 Citations (Scopus)

EGCG disaggregates amyloid-like fibrils formed by Plasmodium falciparum merozoite surface protein 2

Chandrashekaran, I., Adda, C., MacRaild, C., Anders, R. & Norton, R., 2011, In : Archives of Biochemistry and Biophysics. 513, 2, p. 153 - 157 5 p.

Research output: Contribution to journalArticleResearchpeer-review

20 Citations (Scopus)

Embryonic toxin expression in the cone snail conus victoriae - primed to kill or divergent function?

Safavi-Hemami, H., Siero, W. A., Kuang, Z., Williamson, N. A., Karas, J. A., Page, L. R., MacMillan, D., Kompella, S. N., Adams, D. J., Norton, R. S. & Purcell, A. W., 2011, In : Journal of Biological Chemistry. 286, 25, p. 22546 - 22557 12 p.

Research output: Contribution to journalArticleResearchpeer-review

37 Citations (Scopus)

Engineering of a bis-chelator motif into a protein alpha-helix for rigid lanthanide binding and paramagnetic NMR spectroscopy

Swarbrick, J., Ung, P., Su, X-C., Maleckis, A., Chhabra, S., Huber, T., Otting, G. & Graham, B., 2011, In : Chemical Communications. 47, p. 7368 - 7370 3 p.

Research output: Contribution to journalArticleResearchpeer-review

3 Citations (Scopus)

Ethanol extracts of saw palmetto contain the indirectly acting sympathomimetic: tyramine

Chua, T., Simpson, J. & Ventura, S., 2011, In : Prostate. 71, 1, p. 71 - 80 10 p.

Research output: Contribution to journalArticleResearchpeer-review

10 Citations (Scopus)

Exchange enhanced sensitivity gain for solvent-exchangeable protons in 2D (1)H-(15)N heteronuclear correlation spectra acquired with band-selective pulses

Yao, S., Hinds, M., Murphy, J. & Norton, R., 2011, In : Journal of Magnetic Resonance. 211, 2, p. 243 - 247 5 p.

Research output: Contribution to journalArticleResearchpeer-review

8 Citations (Scopus)

Fatty acid binding proteins: potential chaperones of cytosolic drug transport in the enterocyte?

Trevaskis, N., Nguyen, G., Scanlon, M. & Porter, C., 2011, In : Pharmaceutical Research. 28, 9, p. 2176 - 2190 15 p.

Research output: Contribution to journalArticleResearchpeer-review

26 Citations (Scopus)

Fragment-based design of ligands targeting a novel site on the integrase enzyme of human immunodeficiency virus 1

Wielens, J., Headey, S., Deadman, J., Rhodes, D., Le, G., Parker, M., Chalmers, D. & Scanlon, M., 2011, In : ChemMedChem. 6, 4, p. 258 - 261 4 p.

Research output: Contribution to journalArticleResearchpeer-review

5 Citations (Scopus)

Free radical hydrostannylation of unactivated alkenes with chiral trialkylstannanes

Kavanagh, Y., Ford, L. & Schiesser, C. H., 22 Aug 2011, In : Organometallics. 30, 16, p. 4387-4392 6 p.

Research output: Contribution to journalArticleResearchpeer-review

16 Citations (Scopus)

Further investigations into the N-demethylation of oripavine using iron and stainless steel

Orbell, G. & Scammells, P., 2011, In : Organic and Biomolecular Chemistry. 9, 4, p. 1008 - 1011 4 p.

Research output: Contribution to journalArticleResearchpeer-review

81 Citations (Scopus)

Gadolinium tagging for high-precision measurements of 6 nm distances in protein assemblies by EPR.

Yagi, H., Banerjee, D., Graham, B., Huber, T., Goldfarb, D. & Otting, G., 2011, In : Journal of the American Chemical Society. 133, 27, p. 10418 - 10421 4 p.

Research output: Contribution to journalArticleResearchpeer-review

8 Citations (Scopus)

Gas-phase formation and reactions of radical cations of guanosine, deoxyguanosine and their homodimers and heterodimers

Feketeova, L., Yuriev, E., Orbell, J., Khairallah, G. & O'Hair, R., 2011, In : International Journal of Mass Spectrometry. 304, 2-3, p. 74 - 82 9 p.

Research output: Contribution to journalArticleResearchpeer-review

21 Citations (Scopus)

Grignard reactions in pyridinium and phosphonium ionic liquids

Ford, L., Atefi, F., Singer, R. & Scammells, P., 2011, In : European Journal of Organic Chemistry. 2011, 5, p. 942 - 950 9 p.

Research output: Contribution to journalArticleResearchpeer-review

48 Citations (Scopus)

Identification and development of specific inhibitors for insulin-regulated aminopeptidase as a new class of cognitive enhancers

Albiston, A., Diwakarla, S., Fernando, R., Mountford, S., Yeatman, H., Morgan, B., Pham, V., Holien, J., Parker, M., Thompson, P. & Chai, S., 2011, In : British Journal of Pharmacology. 164, 1, p. 37 - 47 11 p.

Research output: Contribution to journalArticleResearchpeer-review

8 Citations (Scopus)

IMIDAZOLIDIN-4-ones: their syntheses and applications

Blackmore, T. & Thompson, P., 2011, In : Heterocycles. 83, 9, p. 1953 - 1975 23 p.

Research output: Contribution to journalArticleResearchpeer-review

19 Citations (Scopus)

Inhibitors of human 20 alpha-hydroxysteroid dehydrogenase (AKR1C1)

El-Kabbani, O., Dhagat, U. & Hara, A., 2011, In : Journal of Steroid Biochemistry and Molecular Biology. 125, 1-2 (SI), p. 105 - 111 7 p.

Research output: Contribution to journalArticleResearchpeer-review

24 Citations (Scopus)

Involvement of the aldo-keto reductase, AKR1B10, in mitomycin-c resistance through reactive oxygen species-dependent mechanisms

Matsunaga, T., Yamane, Y., Keiko, L., Endo, S., Banno, Y., El-Kabbani, O. & Hara, A., 2011, In : Anti-Cancer Drugs. 22, 5, p. 402 - 408 7 p.

Research output: Contribution to journalArticleResearchpeer-review

25 Citations (Scopus)

Isoform-selective inhibition of phosphoinositide 3-kinase: identification of a new region of nonconserved amino acids critical for p110 alpha inhibition

Zheng, Z., Amran, S., Thompson, P. & Jennings, I., 2011, In : Molecular Pharmacology. 80, 4, p. 657 - 664 8 p.

Research output: Contribution to journalArticleResearchpeer-review

35 Citations (Scopus)

Lactam-stabilized helical analogues of the analgesic mu-conotoxin KIIIA

Khoo, K., Wilson, M., Smith, B., Zhang, M-M., Gulyas, J., Yoshikami, D., Rivier, J., Bulaj, G. & Norton, R., 2011, In : Journal of Medicinal Chemistry. 54, 21, p. 7558 - 7566 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Lipid-based formulations: exploring the link between in vitro supersaturation and in vivo exposure

Porter, C. J. H., Anby, M. U., Warren, D. B., Williams, H. D., Benameur, H. & Pouton, C. W., 2011, Bull. Tech. Gattefosse, 104, p. 60-68 9 p.

Research output: Contribution to specialist publicationArticleOther

5 Citations (Scopus)

Modeling the molecular basis for α4β1 integrin antagonism

Hutt, O. E., Saubern, S. & Winkler, D., 2011, In : Bioorganic & Medicinal Chemistry. 19, 19, p. 5903-5911 9 p.

Research output: Contribution to journalArticleResearchpeer-review

5 Citations (Scopus)

Modelling topoisomerase I inhibition by minor groove binders

Winkler, D., 2011, In : Bioorganic & Medicinal Chemistry. 19, 4, p. 1450 - 1457 8 p.

Research output: Contribution to journalArticleResearchpeer-review

13 Citations (Scopus)

Murine interleukin-3: structure, dynamics, and conformational heterogeneity in solution

Yao, S., Young, I., Norton, R. & Murphy, J., 2011, In : Biochemistry. 50, 13, p. 2464 - 2477 14 p.

Research output: Contribution to journalArticleResearchpeer-review

629 Citations (Scopus)

Nanomaterials: applications in cancer imaging and therapy

Barreto Solano, J. A., O'Malley, W., Kubeil, M., Graham, B., Stephan, H. & Spiccia, L., 2011, In : Advanced Materials. 23, 12, p. 18 - 40 23 p.

Research output: Contribution to journalArticleResearchpeer-review

7 Citations (Scopus)

New methodology for the N-alkylation of 2-amino-3-acylthiophenes

Scammells, P., Flynn, B. & Aurelio, L., 2011, In : Organic and Biomolecular Chemistry. 9, 13, p. 4886 - 4902 17 p.

Research output: Contribution to journalArticleResearchpeer-review

12 Citations (Scopus)

Peptide Inhibitors of the Malaria Surface Protein, Apical Membrane Antigen 1: Identification of Key Binding Residues

Lee, E., Yao, S., Sabo, J., Fairlie, W., Stevenson, R., Harris, K., Anders, R., Foley, M. & Norton, R., 2011, In : Biopolymers. 95, 5 (SI), p. 354 - 364 11 p.

Research output: Contribution to journalArticleResearchpeer-review

13 Citations (Scopus)

Peptide inhibitors of xenoreactive antibodies mimic the interaction profile of the native carbohydrate antigens

Agostino, M., Sandrin, M., Thompson, P., Ramsland, P. & Yuriev, E., 2011, In : Biopolymers. 96, 2, p. 193 - 206 14 p.

Research output: Contribution to journalArticleResearchpeer-review

18 Citations (Scopus)

Peroxidase catalysed cross-Linking of an intrinsically unstructured protein via dityrosine bonds in the oocyst wall of the apicomplexan parasite, Eimeria maxima

Mai, K., Smith, N., Feng, Z-P., Katrib, M., Slapetova, I., Wallach, M., Luxford, C., Davies, M., Zhang, X., Norton, R. & Belli, S., 2011, In : International Journal for Parasitology. 41, 11, p. 1157 - 1164 8 p.

Research output: Contribution to journalArticleResearchpeer-review

2 Citations (Scopus)
8 Citations (Scopus)

Principal signalling complexes in haematopoiesis: Structural aspects and mimetic discovery

Tarasova, A., Haylock, D. & Winkler, D., 2011, In : Cytokine and Growth Factor Reviews. 22, 4, p. 231-253 23 p.

Research output: Contribution to journalArticleResearchpeer-review

5 Citations (Scopus)

Probing the inhibitor selectivity pocket of human 20 alpha-hydroxysteroid dehydrogenase (AKR1C1) with X-ray crystallography and site-directed mutagenesis

El-Kabbani, O., Dhagat, U., Soda, M., Endo, S., Matsunaga, T. & Hara, A., 2011, In : Bioorganic and Medicinal Chemistry Letters. 21, 8, p. 2564 - 2567 4 p.

Research output: Contribution to journalArticleResearchpeer-review

5 Citations (Scopus)

Protective effect of rat aldo-keto reductase (AKR1C15) on endothelial cell damage elicited by 4-hydroxy-2-nonenal

Matsunaga, T., Shinoda, Y., Endo, S., Inoue, Y., El-Kabbani, O. & Hara, A., 2011, In : Chemico-Biological Interactions. 191, 1-3, p. 367 - 370 4 p.

Research output: Contribution to journalArticleResearchpeer-review

33 Citations (Scopus)

Roles of rat and human aldo-keto reductases in metabolism of farnesol and geranylgeraniol

Endo, S., Matsunaga, T., Ohta, C., Soda, M., Kanamori, A., Kitade, Y., Ohno, S., Tajima, K., El-Kabbani, O. & Hara, A., 2011, In : Chemico-Biological Interactions. 191, 1-3, p. 261 - 268 8 p.

Research output: Contribution to journalArticleResearchpeer-review

19 Citations (Scopus)

Schizophrenia: a systematic review of the disease state, current therapeutics and their molecular mechanisms of action

Shin, J., Malone, D., Crosby, I. & Capuano, B., 2011, In : Current Medicinal Chemistry. 18, 9, p. 1380 - 1404 25 p.

Research output: Contribution to journalArticleResearchpeer-review

41 Citations (Scopus)

Selective inhibition of the tumor marker aldo-keto reductase family member 1B10 by oleanolic acid

Takemura, M., Endo, S., Matsunaga, T., Soda, M., Zhao, H-T., El-Kabbani, O., Tajima, K., Iinuma, M. & Hara, A., 2011, In : Journal of Natural Products. 74, 5, p. 1201 - 1206 6 p.

Research output: Contribution to journalArticleResearchpeer-review

226 Citations (Scopus)

Status of GPCR modeling and docking as reflected by community-wide GPCR Dock 2010 assessment

Kufareva, I., Rueda, M., Katritch, V., Stevens, R. C., Abagyan, R., McRobb, F. M., Capuano, B., Crosby, I. T., Chalmers, D. K., Yuriev, E., Simms, J. W., Sexton, P., Wootten, D. L. & Hall, N. E., 2011, In : Structure. 19, 8, p. 1108 - 1126 19 p.

Research output: Contribution to journalArticleResearchpeer-review

7 Citations (Scopus)

Structure of rat aldose reductase-like protein AKR1B14 holoenzyme: Probing the role of His269 in coenzyme binding by site-directed mutagenesis

Sundaram, K., Dhagat, U., Endo, S., Chung, R., Matsunaga, T., Hara, A. & El-Kabbani, O., 2011, In : Bioorganic and Medicinal Chemistry Letters. 21, 2, p. 801 - 804 4 p.

Research output: Contribution to journalArticleResearchpeer-review

13 Citations (Scopus)

Synthesis, colloidal stability and 64Cu labeling of iron oxide nanoparticles bearing different macrocyclic ligands

Barreto Solano, J. A., Matterna, M., Graham, B., Stephan, H. & Spiccia, L., 2011, In : New Journal of Chemistry. 35, 11, p. 2705 - 2712 8 p.

Research output: Contribution to journalArticleResearchpeer-review

56 Citations (Scopus)

Synthesis, structure, and DNA cleavage properties of copper(II) complexes of 1,4,7-triazacyclononane ligands featuring pairs of guanidine pendants

Tjioe, L., Joshi, T., Brugger, J., Graham, B. & Spiccia, L., 2011, In : Inorganic Chemistry. 50, 2, p. 621 - 635 15 p.

Research output: Contribution to journalArticleResearchpeer-review

14 Citations (Scopus)

Synthesis and utility of 2-halo-O(6)-(benzotriazol-1-yl)-functionalized purine nucleosides

Devine, S. & Scammells, P., 2011, In : European Journal of Organic Chemistry. 2011, 6, p. 1092 - 1098 7 p.

Research output: Contribution to journalArticleResearchpeer-review