Research Output 1977 2019

Filter
Article
2012
25 Citations (Scopus)

Modelling human embryoid body cell adhesion to a combinatorial library of polymer surfaces

Epa, C., Yang, J., Mei, Y., Hook, A. L., Langer, R., Anderson, D. G., Davies, M. C., Alexander, M. R. & Winkler, D. A., 2012, In : Journal of Materials Chemistry. 22, 39, p. 20902 - 20906 5 p.

Research output: Contribution to journalArticleResearchpeer-review

Molecular characterization of lipopolysaccharide binding to human alpha-1-acid glycoprotein

Huang, J. X., Azad, M. A. K., Yuriev, E., Baker, M. A., Nation, R. L., Li, J., Cooper, M. A. & Velkov, T., 2012, In : Journal of Lipids. 2012, p. 1 - 15 15 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
15 Citations (Scopus)

Omega-Conotoxin GVIA mimetics that bind and inhibit neuronal Ca v2.2 ion channels

Tranberg, C. E., Yang, A., Vetter, I., McArthur, J. R., Baell, J. B., Lewis, R. J., Tuck, K. L. & Duggan, P., 2012, In : Marine Drugs. 10, 10, p. 2349 - 2368 20 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
45 Citations (Scopus)

Oxazolidinone-promoted, torquoselective Nazarov cyclizations

Kerr, D. J., Miletic, M., Chaplin, J. H., White, J. M. & Flynn, B. L., 2012, In : Organic Letters. 14, 7, p. 1732 - 1735 4 p.

Research output: Contribution to journalArticleResearchpeer-review

44 Citations (Scopus)

Phosphodiester cleavage properties of copper(II) complexes of 1,4,7-triazacyclononane ligands bearing single alkyl guanidine pendants

Tjioe, L., Joshi, T., Forsyth, C. M., Moubaraki, B., Murray, K. S., Brugger, J., Graham, B. & Spiccia, L., 2012, In : Inorganic Chemistry. 51, 2, p. 939 - 953 15 p.

Research output: Contribution to journalArticleResearchpeer-review

7 Citations (Scopus)

Polonovski-type N-demethylation of N-methyl alkaloids using substituted ferrocene redox catalysts

Orbell, G. B. & Scammells, P. J., 2012, In : Synthesis. 44, 16, p. 2587 - 2594 8 p.

Research output: Contribution to journalArticleResearchpeer-review

219 Citations (Scopus)

Quantitative structure–property relationship modeling of diverse materials properties

Le, T., Epa, V. C., Burden, F. & Winkler, D., 2012, In : Chemical Reviews. 112, 5, p. 2889-2919 31 p.

Research output: Contribution to journalArticleResearchpeer-review

6 Citations (Scopus)

Reduction of cytotoxic p-Quinone metabolites of tert-butylhydroquinone by human aldo-keto reductase (AKR) 1B10

Matsunaga, T., Endo, S., Takemura, M., Soda, M., Yamamura, K., Tajima, K., Miura, T., Terada, T., El-Kabbani, O. & Hara, A., 2012, In : Drug metabolism and pharmacokinetics. 27, 5, p. 553 - 558 6 p.

Research output: Contribution to journalArticleResearchpeer-review

31 Citations (Scopus)

Remarkable in vitro bactericidal activity of bismuth(III) sulfonates against Helicobacter pylori

Andrews, P. C., Busse, M., Deacon, G. B., Ferrero, R. L., Junk, P. C., Maclellan, J. G. & Vom, A., 2012, In : Dalton Transactions. 41, 38, p. 11798 - 11806 9 p.

Research output: Contribution to journalArticleResearchpeer-review

7 Citations (Scopus)

Robust, quantitative tools for modelling ex-vivo expansion of haematopoietic stem cells and progenitors

Winkler, D. & Burden, F., 2012, In : Molecular BioSystems. 8, 3, p. 913-920 8 p.

Research output: Contribution to journalArticleResearchpeer-review

16 Citations (Scopus)

Role of the helical structure of the N-terminal region of plasmodium falciparum merozoite surface protein 2 in fibril formation and membrane interaction

Zhang, X., Adda, C. G., Low, A., Zhang, J., Zhang, W., Sun, H., Tu, X., Anders, R. F. & Norton, R. S., 2012, In : Biochemistry. 51, 7, p. 1380 - 1387 8 p.

Research output: Contribution to journalArticleResearchpeer-review

24 Citations (Scopus)

Selective inhibition of human type-5 17 beta-hydroxysteroid dehydrogenase (AKR1C3) by baccharin, a component of Brazilian propolis

Endo, S., Matsunaga, T., Kanamori, A., Otsuji, Y., Nagai, H., Sundaram, K., El-Kabbani, O., Toyooka, N., Ohta, S. & Hara, A., 2012, In : Journal of Natural Products. 75, 4, p. 716 - 721 6 p.

Research output: Contribution to journalArticleResearchpeer-review

13 Citations (Scopus)

Self-organizing circuitry and emergent computation in mouse embryonic stem cells

Halley, J. D., Smith-Miles, K. A., Winkler, D. A., Kalkan, T., Huang, S. & Smith, A., 2012, In : Stem Cell Research. 8, 2, p. 324-333 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
1 Citation (Scopus)

Simplified platensimycin analogues as antibacterial agents

Krsta, D., Ku, K. U. C., Crosby, I. T., Capuano, B. & Manallack, D. T., 2012, In : MedChemComm. 3, 2, p. 244 - 249 6 p.

Research output: Contribution to journalArticleResearchpeer-review

28 Citations (Scopus)

Sites of action of ghrelin receptor ligands in cardiovascular control

Callaghan, B., Hunne, B., Hirayama, H., Sartor, D. M., Nguyen, T. V., Abogadie, F. C., Ferens, D. M., McIntyre, P. B., Ban, K., Baell, J. B., Furness, J. B. & Brock, J. A., 2012, In : American Journal of Physiology - Heart and Circulatory Physiology. 303, 8, p. 1011 - 1021 11 p.

Research output: Contribution to journalArticleResearchpeer-review

17 Citations (Scopus)

Spin-coupled theory for 'N electrons in M orbitals' active spaces

Karadakov, P. B., Cooper, D. L., Salter-Duke, B. J. & Li, J., 2012, In : The Journal of Physical Chemistry A. 116, 26, p. 7238 - 7244 7 p.

Research output: Contribution to journalArticleResearchpeer-review

13 Citations (Scopus)

Structural basis for 5′-end-specific recognition of single-stranded DNA by the R3H domain from human Sμbp-2

Jaudzems, K., Jia, X., Yagi, H., Zhulenkovs, D., Graham, B., Otting, G. & Liepinsh, E., 23 Nov 2012, In : Journal of Molecular Biology. 424, 1-2, p. 42-53 12 p.

Research output: Contribution to journalArticleResearchpeer-review

6 Citations (Scopus)

Structure-activity relationship exploration of Kv1.3 blockers based on diphenoxylate

Nguyen, W., Howard, B. L., Jenkins, D., Wulff, H., Thompson, P. & Manallack, D. T., 2012, In : Bioorganic and Medicinal Chemistry Letters. 22, 23, p. 7106 - 7109 4 p.

Research output: Contribution to journalArticleResearchpeer-review

25 Citations (Scopus)

Structure-activity relationships for the binding of polymyxins with human alpha-1-acid glycoprotein

Azad, M. A. K., Huang, J. X., Cooper, M. A., Roberts, K. D., Thompson, P., Nation, R. L., Li, J. & Velkov, T., 2012, In : Biochemical Pharmacology. 84, 3, p. 278 - 291 14 p.

Research output: Contribution to journalArticleResearchpeer-review

18 Citations (Scopus)

Structure of S. aureus HPPK and the discovery of a new substrate site inhibitor

Chhabra, S., Dolezal, O., Collins, B. M., Newman, J., Simpson, J. S., Macreadie, I. G., Fernley, R., Peat, T. & Swarbrick, J. D., 2012, In : PLoS ONE. 7, 1, 16 p., e29444.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
2 Citations (Scopus)

Structure of the His269Arg mutant of the rat aldose reductase-like protein AKR1B14 complexed with NADPH

Sundaram, K., Endo, S., Matsunaga, T., Tanaka, N., Hara, A. & El-Kabbani, O., 2012, In : Acta Crystallographica. Section F: Structural Biology Communications. 68, 4, p. 400 - 403 4 p.

Research output: Contribution to journalArticleResearchpeer-review

136 Citations (Scopus)

Suppression of cytokine signaling by SOCS3: characterization of the mode of inhibition and the basis of its specificity

Babon, J. J., Kershaw, N. J., Murphy, J. M., Varghese, L. N., Laktyushin, A., Young, S. N., Lucet, I. S., Norton, R. S. & Nicola, N. A., 2012, In : Immunity. 36, 2, p. 239 - 250 12 p.

Research output: Contribution to journalArticleResearchpeer-review

4 Citations (Scopus)

Synthesis and biological evaluation of adenosines with heterobicyclic and polycyclic N6-substituents as adenosine A1 receptor agonists

Gosling, J. I., Baker, S. P., Haynes, J. M., Kassiou, M., Pouton, C. W., Warfe, L., White, P. J. & Scammells, P. J., 2012, In : ChemMedChem. 7, 7, p. 1191 - 1201 11 p.

Research output: Contribution to journalArticleResearchpeer-review

24 Citations (Scopus)

Synthesis and biological evaluation of N-substituted noscapine analogues

Debono, A. J., Xie, J. H., Ventura, S., Pouton, C. W., Capuano, B. & Scammells, P. J., 2012, In : ChemMedChem. 7, 12, p. 2122 - 2133 12 p.

Research output: Contribution to journalArticleResearchpeer-review

34 Citations (Scopus)

Synthesis and characterization of novel 2-amino-3-benzoylthiophene derivatives as biased allosteric agonists and modulators of the adenosine A1 receptor

Valant, C., Aurelio, L., Devine, S. M., Ashton, T. D., White, J. M., Sexton, P. M., Christopoulos, A. & Scammells, P. J., 2012, In : Journal of Medicinal Chemistry. 55, 5, p. 2367 - 2375 9 p.

Research output: Contribution to journalArticleResearchpeer-review

4 Citations (Scopus)

Synthesis and pharmacological evaluation of 4-iminothiazolidinones for inhibition of PI3 kinase

Pinson, J-A., Schmidt-Kittler, O., Frazzetto, M., Zheng, Z., Jennings, I., Kinzler, K., Vogelstein, B., Chalmers, D. K. & Thompson, P., 2012, In : Australian Journal of Chemistry. 65, 10, p. 1396 - 1404 9 p.

Research output: Contribution to journalArticleResearchpeer-review

15 Citations (Scopus)

Synthesis and pharmacological evaluation of dual acting antioxidant A2A adenosine receptor agonists

Hausler, N., Devine, S., McRobb, F. M., Warfe, L., Pouton, C. W., Haynes, J. M., Bottle, S. E., White, P. J. & Scammells, P. J., 2012, In : Journal of Medicinal Chemistry. 55, 7, p. 3521 - 3534 14 p.

Research output: Contribution to journalArticleResearchpeer-review

5 Citations (Scopus)

Synthesis and SAR study of 4-arylpiperidines and 4-aryl-1,2,3,6- tetrahydropyridines as 5-HT2C agonists

Conway, R., Valant, C., Christopoulos, A., Robertson, A. D., Capuano, B. & Crosby, I. T., 2012, In : Bioorganic and Medicinal Chemistry Letters. 22, 7, p. 2560 - 2564 5 p.

Research output: Contribution to journalArticleResearchpeer-review

14 Citations (Scopus)

The 1.2 A resolution crystal structure of TcpG, the Vibrio cholerae DsbA disulfide-forming protein required for pilus and cholera-toxin production

Walden, P. M., Heras, B., Chen, K-E., Halili, M. A., Rimmer, K., Sharma, P., Scanlon, M. & Martin, J. L., 2012, In : Acta Crystallographica Section D: Biological Crystallography. 68, 10, p. 1290 - 1302 13 p.

Research output: Contribution to journalArticleResearchpeer-review

48 Citations (Scopus)

The J-UNIO protocol for automated protein structure determination by NMR in solution

Serrano, P., Pedrini, B., Mohanty, B., Geralt, M., Herrmann, T. & Wüthrich, K., Aug 2012, In : Journal of Biomolecular NMR. 53, 4, p. 341-354 14 p.

Research output: Contribution to journalArticleResearchpeer-review

23 Citations (Scopus)

The N-terminal domains of SOCS proteins: A conserved region in the disordered N-termini of SOCS4 and 5

Feng, Z-P., Chandrashekaran, I. R., Low, A., Speed, T. P., Nicholson, S. E. & Norton, R. S., 2012, In : Proteins: Structure, Function, and Bioinformatics. 80, 3, p. 946 - 957 12 p.

Research output: Contribution to journalArticleResearchpeer-review

8 Citations (Scopus)

Tumour targeting of Auger emitters using DNA ligands conjugated to octreotate

Lobachevsky, P. N., Smith, J., Denoyer, D., Skene, C. E., White, J. M., Flynn, B. L., Kerr, D. J., Hicks, R. & Martin, R. F., 2012, In : International Journal of Radiation Biology. 88, 12, p. 1009 - 1018 10 p.

Research output: Contribution to journalArticleResearchpeer-review

60 Citations (Scopus)

Unzipping the role of chirality in nanoscale self-assembly of tripeptide hydrogels

Marchesan, S., Waddington, L., Easton, C. D., Winkler, D. A., Goodall, L., Forsythe, J. S. & Hartley, P. G., 2012, In : Nanoscale. 4, 21, p. 6752-6760 9 p.

Research output: Contribution to journalArticleResearchpeer-review

14 Citations (Scopus)

Virtual screening using a conformationally flexible target protein: models for ligand binding to p38 alpha MAPK

Vinh, N., Simpson, J. S., Scammells, P. J. & Chalmers, D. K., 2012, In : Journal of Computer-Aided Molecular Design. 26, 4, p. 409 - 423 15 p.

Research output: Contribution to journalArticleResearchpeer-review

2011
13 Citations (Scopus)

A computational approach for exploring carbohydrate recognition by lectins in innate immunity

Agostino, M., Yuriev, E. & Ramsland, P. A., 2011, In : Frontiers in Immunology. 2, JUN, 14 p., 23.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
5 Citations (Scopus)

Activation of aldo-keto reductase family member 1B14 (AKR1B14) by bile acids: Activation mechanism and bile acid-binding site

Endo, S., Matsunaga, T., Fujita, A., Kuragano, T., Soda, M., Sundaram, K., Dhagat, U., Tajima, K., El-Kabbani, O. & Hara, A., 2011, In : Biochimie. 93, 9, p. 1476 - 1486 11 p.

Research output: Contribution to journalArticleResearchpeer-review

8 Citations (Scopus)

Active site similarity between human and plasmodium falciparum phosphodiesterases: considerations for antimalarial drug design

Howard, B., Thompson, P. & Manallack, D., 2011, In : Journal of Computer-Aided Molecular Design. 25, 8, p. 753 - 762 10 p.

Research output: Contribution to journalArticleResearchpeer-review

11 Citations (Scopus)

A facile, click chemistry-based approach to assembling fluorescent chemosensors for protein tyrosine kinases

Kamaruddin, M., Ung, P., Hossain, M., Jarasrassamee, B., O'Malley, W., Thompson, P., Scanlon, D., Cheng, H-C. & Graham, B., 2011, In : Bioorganic and Medicinal Chemistry Letters. 21, 1, p. 329 - 331 3 p.

Research output: Contribution to journalArticleResearchpeer-review

78 Citations (Scopus)

A family of helminth molecules that modulate innate cell responses via molecular mimicry of host antimicrobial peptides

Robinson, M., Donnelly, S., Hutchinson, A., To, J., Taylor, N., Norton, R., Perugini, M. & Dalton, J., 2011, In : PLoS Pathogens. 7, 5, p. 1 - 14 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
2 Citations (Scopus)

A gel-capture assay for characterizing the sialyl-glycan selectivity of influenza viruses

Velkov, T., Thompson, P., El-Kabbani, O., Lindh, F., Stambas, J. & Rockman, S., 2011, In : Acta Virologica. 55, 2, p. 131 - 137 7 p.

Research output: Contribution to journalArticleResearchpeer-review

35 Citations (Scopus)

A general model for binary cell fate decision gene circuits with degeneracy: indeterminacy and switch behavior in the absence of cooperativity

Andrecut, M., Halley, J., Winkler, D. & Huang, S., 2011, In : PLoS ONE. 6, 5, 9 p., e19358.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
7 Citations (Scopus)

Aldo-keto reductase 1C15 as a quinone reductase in rat endothelial cell: Its involvement in redox cycling of 9,10-phenanthrenequinone

Matsunaga, T., Shinoda, Y., Inoue, Y., Haga, M., Endo, S., El-Kabbani, O. & Hara, A., 2011, In : Free Radical Research. 45, 7, p. 848 - 857 10 p.

Research output: Contribution to journalArticleResearchpeer-review

198 Citations (Scopus)

Allosteric modulation of G protein-coupled receptors: A pharmacological perspective

Keov, P., Sexton, P. & Christopoulos, A., 2011, In : Neuropharmacology. 60, 1, p. 24 - 35 12 p.

Research output: Contribution to journalArticleResearchpeer-review

36 Citations (Scopus)

A mechanistic investigation of cell-penetrating Tat peptides with supported lipid membranes

Piantavigna, S., McCubbin, G., Boehnke, S., Graham, B., Spiccia, L. & Martin, L., 2011, In : Biochimica et Biophysica Acta - Biomembranes. 1808, 7, p. 1811 - 1817 7 p.

Research output: Contribution to journalArticleResearchpeer-review

58 Citations (Scopus)

Analogs of the sea anemone potassium channel blocker ShK for the treatment of autoimmune diseases

Beeton, C., Pennington, M. & Norton, R., 2011, In : Inflammation & Allergy - Drug Targets. 10, 5, p. 313 - 321 9 p.

Research output: Contribution to journalArticleResearchpeer-review

38 Citations (Scopus)

An iminodiacetic acid based lanthanide binding tag for paramagnetic exchange NMR spectroscopy

Swarbrick, J., Ung, P., Chhabra, S. & Graham, B., 2011, In : Angewandte Chemie - International Edition. 50, 19, p. 4403 - 4406 4 p.

Research output: Contribution to journalArticleResearchpeer-review

11 Citations (Scopus)

A novel deletion-insertion mutation identified in exon 3 of FXN in two siblings with a severe Friedreich ataxia phenotype

Evans-Galea, M., Corben, L., Hasell, J., Galea, C., Fahey, M., Du Sart, D. & Delatycki, M., 2011, In : Neurogenetics. 12, 4, p. 307 - 313 7 p.

Research output: Contribution to journalArticleResearchpeer-review

26 Citations (Scopus)

Apical membrane antigen 1 as an anti-malarial drug target

MacRaild, C., Anders, R., Foley, M. & Norton, R., 2011, In : Current Topics in Medicinal Chemistry. 11, 16, p. 2039 - 2047 9 p.

Research output: Contribution to journalArticleResearchpeer-review

86 Citations (Scopus)

Binding of low molecular weight inhibitors promotes large conformational changes in the dengue virus NS2B-NS3 protease: fold analysis by pseudocontact shifts

de la Cruz, L., Nguyen, T., Ozawa, K., Shin, J., Graham, B., Huber, T. & Otting, G., 2011, In : Journal of the American Chemical Society. 133, 47, p. 19205 - 19215 11 p.

Research output: Contribution to journalArticleResearchpeer-review

16 Citations (Scopus)

Carbohydrate-mimetic peptides: structural aspects of mimicry and therapeutic implications

Agostino, M., Sandrin, M., Thompson, P., Farrugia, W., Ramsland, P. & Yuriev, E., 2011, In : Expert Opinion on Biological Therapy. 11, 2, p. 211 - 224 14 p.

Research output: Contribution to journalArticleResearchpeer-review