Research Output 1977 2019

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2013
20 Citations (Scopus)
23 Citations (Scopus)

Scaffold-divergent synthesis of ring-fused indoles, quinolines, and quinolones via iodonium-induced reaction cascades

Halim, R., Aurelio, L., Scammells, P. J. & Flynn, B. L., 2013, In : Journal of Organic Chemistry. 78, 10, p. 4708 - 4718 11 p.

Research output: Contribution to journalArticleResearchpeer-review

22 Citations (Scopus)

Strategies for the development of conotoxins as new therapeutic leads

Brady, R., Baell, J. B. & Norton, R. S., 2013, In : Marine Drugs. 11, 7, p. 2293 - 2313 21 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
250 Citations (Scopus)

Structural basis for modulation of a G-protein-coupled receptor by allosteric drugs

Dror, R., Green, H. F., Valant, C., Borhani, D. W., Valcourt, J. R., Pan, A. C., Arlow, D. H., Canals, M., Lane, J. R. D., Rahmani, R. S., Baell, J. B., Sexton, P., Christopoulos, A. & Shaw, D. E., 2013, In : Nature. 503, 7475, p. 295 - 299 5 p.

Research output: Contribution to journalArticleResearchpeer-review

50 Citations (Scopus)

Structure and function of the SPRY/B30.2 domain proteins involved in innate immunity

D'Cruz, A., Babon, J., Norton, R. S., Nicola, N. A. & Nicholson, S. E., 2013, In : Protein Science. 22, 1, p. 1 - 10 10 p.

Research output: Contribution to journalArticleResearchpeer-review

6 Citations (Scopus)

Substrate specificity and inhibitor sensitivity of rabbit 20a-hydroxysteroid dehydrogenase

Endo, S., Arai, Y., Hara, A., Kitade, Y., Bunai, Y., El-Kabbani, O. & Matsunaga, T., 2013, In : Biological & Pharmaceutical Bulletin. 36, 9, p. 1514 - 1518 5 p.

Research output: Contribution to journalArticleResearchpeer-review

25 Citations (Scopus)

Suppressor of cytokine signaling (SOCS) 5 utilises distinct domains for regulation of JAK1 and interaction with the adaptor protein Shc-1

Linossi, E. M., Chandrashekaran, I. R., Kolesnik, T. B., Murphy, J. M., Webb, A. I., Willson, T. A., Kedzierski, L., Bullock, A. N., Babon, J., Norton, R. S., Nicola, N. A. & Nicholson, S. E., 2013, In : PLoS ONE. 8, 8, p. 1 - 12 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
5 Citations (Scopus)

Synthesis, functional and binding profile of (R)-apomorphine based homobivalent ligands targeting the dopamine D2 receptor

Shonberg, J., Lane, J. R. D., Scammells, P. J. & Capuano, B., 2013, In : MedChemComm. 4, 9, p. 1290 - 1296 7 p.

Research output: Contribution to journalArticleResearchpeer-review

11 Citations (Scopus)

Synthesis, molecular structure, NMR spectroscopic and computational analysis of a selective adenosine A2A antagonist, ZM 241385

Jorg, M., Agostino, M. J., Yuriev, E., Mak, F. S., Miller, N. D., White, J., Scammells, P. J. & Capuano, B., 2013, In : Structural Chemistry. 24, 4, p. 1241 - 1251 11 p.

Research output: Contribution to journalArticleResearchpeer-review

21 Citations (Scopus)

Synthesis and radiopharmacological evaluation of 64Cu-labeled bombesin analogs featuring a bis(2-pyridylmethyl)-1,4,7-triazacyclononane chelator

Bergmann, R., Ruffani, A., Graham, B., Spiccia, L., Steinbach, J., Pietzsch, J. & Stephan, H., 2013, In : European Journal of Medicinal Chemistry. 70, p. 434 - 446 13 p.

Research output: Contribution to journalArticleResearchpeer-review

16 Citations (Scopus)

Synthesis and structure-activity relationship of 2-phenyliminochromene derivatives as inhibitors for aldo-keto reductase (AKR) 1B10

Endo, S., Hu, D. H., Suyama, M., Matsunaga, T., Sugimoto, K., Matsuya, Y., El-Kabbani, O., Kuwata, K., Hara, A., Kitade, Y. & Toyooka, N., 2013, In : Bioorganic & Medicinal Chemistry. 21, 21, p. 6378 - 6384 7 p.

Research output: Contribution to journalArticleResearchpeer-review

38 Citations (Scopus)

Synthesis and structure-activity relationships of phosphonic arginine mimetics as inhibitors of the M1 and M17 aminopeptidases from Plasmodium falciparum

Kannan Sivaraman, K., Paiardini, A., Sienczyk, M., Ruggeri, C., Oellig, C., Dalton, J. P., Scammells, P. J., Drag, M. & McGowan, S., 2013, In : Journal of Medicinal Chemistry. 56, 12, p. 5213 - 5217 5 p.

Research output: Contribution to journalArticleResearchpeer-review

5 Citations (Scopus)

Synthesis of BVD15 peptide analogues as models for radioligands in tumour imaging

Liu, M., Mountford, S. J., Zhang, L., Lee, I. C. J., Herzog, H. & Thompson, P., 2013, In : International Journal of Peptide Research and Therapeutics. 19, p. 33 - 41 9 p.

Research output: Contribution to journalArticleResearchpeer-review

9 Citations (Scopus)

The acid/base profile of the human metabolome and natural products

Manallack, D. T., Dennis, M., Kelly, M. R., Prankerd, R. J., Yuriev, E. & Chalmers, D. K., 2013, In : Molecular Informatics. 32, 5-6, p. 505 - 515 11 p.

Research output: Contribution to journalArticleResearchpeer-review

19 Citations (Scopus)

The relaxin receptor (RXFP1) utilizes hydrophobic moieties on a signaling surface of its N-terminal low density lipoprotein class A module to mediate receptor activation

Kong, R. C. K., Petrie, E. J., Mohanty, B., Ling, J., Lee, J. C. Y., Gooley, P. R. & Bathgate, R., 2013, In : Journal of Biological Chemistry. 288, 39, p. 28138 - 28151 14 p.

Research output: Contribution to journalArticleResearchpeer-review

94 Citations (Scopus)

The significance of acid/base properties in drug discovery

Manallack, D. T., Prankerd, R. J., Yuriev, E., Oprea, T. I. & Chalmers, D. K., 2013, In : Chemical Society Reviews. 42, 2, p. 485 - 496 12 p.

Research output: Contribution to journalArticleResearchpeer-review

20 Citations (Scopus)

The structure of integrin a1I domain in complex with a collagen-mimetic peptide

Chin, Y. K-Y., Headey, S. J., Mohanty, B., Patil, R., McEwan, P. A., Swarbrick, J. D., Mulhern, T. D., Emsley, J., Simpson, J. S. & Scanlon, M., 2013, In : Journal of Biological Chemistry. 288, 52, p. 36796 - 36809 14 p.

Research output: Contribution to journalArticleResearchpeer-review

50 Citations (Scopus)

Three-dimensional protein fold determination from backbone amide pseudocontact shifts generated by lanthanide tags at multiple sites

Yagi, H., Pilla, K. B., Maleckis, A., Graham, B., Huber, T. & Otting, G., 2013, In : Structure. 21, 6, p. 883 - 890 8 p.

Research output: Contribution to journalArticleResearchpeer-review

2012
7 Citations (Scopus)

7-Selenabicyclo[2.2.1]heptane

Macdougall, P. E., Aitken, H. M., Scammells, P. J., Kavanagh, Y., Kyne, S. H. & Schiesser, C. H., 2012, In : Chemical Communications. 48, 73, p. 9126 - 9128 3 p.

Research output: Contribution to journalArticleOtherpeer-review

7 Citations (Scopus)

9,10-Phenanthrenequinone induces monocytic differentiation of U937 cells through regulating expression of aldo-keto reductase 1C3

Matsunaga, T., Hosogai, M., Arakaki, M., Endo, S., El-Kabbani, O. & Hara, A., 2012, In : Biological & Pharmaceutical Bulletin. 35, 9, p. 1598 - 1602 5 p.

Research output: Contribution to journalArticleResearchpeer-review

9 Citations (Scopus)

9,10-Phenanthrenequinone promotes secretion of pulmonary aldo-keto reductases with surfactant

Matsunaga, T., Haga, M., Watanabe, G., Shinoda, Y., Endo, S., Kajiwara, Y., Tanaka, H., Inagaki, N., El-Kabbani, O. & Hara, A., 2012, In : Cell and Tissue Research. 347, 2, p. 407 - 417 11 p.

Research output: Contribution to journalArticleResearchpeer-review

30 Citations (Scopus)

A C-terminally amidated analogue of ShK is a potent and selective blocker of the voltage-gated potassium channel Kv1.3

Pennington, M. W., Rashid, M. H., Tajhya, R. B., Beeton, C., Kuyucak, S. & Norton, R. S., 2012, In : FEBS Letters. 586, 22, p. 3996 - 4001 6 p.

Research output: Contribution to journalArticleResearchpeer-review

26 Citations (Scopus)

A helical conotoxin from Conus imperialis has a novel cysteine framework and defines a new superfamily

Ye, M., Khoo, K. K., Xu, S., Zhou, M., Boonyalai, N., Chi, C., Galea, C., Wang, C. & Norton, R. S., 2012, In : Journal of Biological Chemistry. 287, 18, p. 14973 - 14983 11 p.

Research output: Contribution to journalArticleResearchpeer-review

84 Citations (Scopus)

A Monod-Wyman-Changeux mechanism can explain G protein-coupled receptor (GPCR) allosteric modulation

Canals, M., Lane, J., Wen, A., Scammells, P., Sexton, P. & Christopoulos, A., 2012, In : Journal of Biological Chemistry. 287, 1, p. 650 - 659 10 p.

Research output: Contribution to journalArticleResearchpeer-review

24 Citations (Scopus)

A new approach to highly substituted cyclopentanoids from a concise formal synthesis of (+)-roseophilin

Kerr, D. J. & Flynn, B. L., 2012, In : Organic Letters. 14, 7, p. 1740 - 1743 4 p.

Research output: Contribution to journalArticleResearchpeer-review

15 Citations (Scopus)

Antibody recognition of cancer-related gangliosides and their mimics investigated using in silico site mapping

Agostino, M. J., Yuriev, E. & Ramsland, P. A., 2012, In : PLoS ONE. 7, 4, 12 p., e35457.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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21 Citations (Scopus)

Antigenic characterization of an intrinsically unstructured protein, plasmodium falciparum merozoite surface protein 2

Adda, C. G., MacRaild, C. A., Reiling, L., Wycherley, K., Boyle, M. J., Kienzle, V., Masendycz, P., Foley, M., Beeson, J. G., Norton, R. S. & Anders, R., 2012, In : Infection and Immunity. 80, 12, p. 4177 - 4185 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
3 Citations (Scopus)

Assessment of the pharmacological properties of 5-methoxyindole derivatives at 5-HT4 receptors

Coupar, I. M., Irving, H. R., Manallack, D. T., Tan, Y. Y., Ayad, F., Di Iulio, J. L., Tochon-Danguy, N. & Iskander, M. N., 2012, In : Journal of Pharmacy and Pharmacology. 64, 8, p. 1099 - 1106 8 p.

Research output: Contribution to journalArticleResearchpeer-review

9 Citations (Scopus)

Characterization of rabbit aldose reductase-like protein with 3?-hydroxysteroid dehydrogenase activity

Endo, S., Matsunaga, T., Kumada, S., Fujimoto, A., Ohno, S., El-Kabbani, O., Hu, D., Toyooka, N., Mano, J., Tajima, K. & Hara, A., 2012, In : Archives of Biochemistry and Biophysics. 527, 1, p. 23 - 30 8 p.

Research output: Contribution to journalArticleResearchpeer-review

2 Citations (Scopus)

Colloidal characteristics and formulation of pure protein particulate vaccines

White, P. J., Hickey, P. LC., Tu, L. S., Headey, S. J., Scanlon, M., Boyd, B. J. & Pouton, C. W., 2012, In : Journal of Pharmacy and Pharmacology. 64, 10, p. 1386 - 1393 8 p.

Research output: Contribution to journalArticleResearchpeer-review

11 Citations (Scopus)

Convergent total syntheses of the pentacyclic lamellarins K, T, U and W via the addition of azomethine ylides to tethered tolans

Flynn, B. L. & Banwell, M., 2012, In : Heterocycles. 84, 2, p. 1141 - 1170 30 p.

Research output: Contribution to journalArticleResearchpeer-review

132 Citations (Scopus)

Copper(II), zinc(II) and nickel(II) complexes as nuclease mimetics

Desbouis, D., Troitsky, I. P., Belousoff, M. J., Spiccia, L. & Graham, B., 2012, In : Coordination Chemistry Reviews. 256, 11-12, p. 897 - 937 41 p.

Research output: Contribution to journalArticleResearchpeer-review

17 Citations (Scopus)

Definition of the binding mode of a new class of phosphoinositide 3-kinase alpha-selective inhibitors using in vitro mutagenesis of non-conserved amino acids and kinetic analysis

Zheng, Z., Amran, S. I., Zhu, J., Schmidt-Kittler, O., Kinzler, K., Vogelstein, B., Shepherd, P. R., Thompson, P. & Jennings, I., 2012, In : Biochemical Journal. 444, p. 529 - 535 7 p.

Research output: Contribution to journalArticleResearchpeer-review

40 Citations (Scopus)

Design, synthesis and evaluation of caffeic acid phenethyl ester-based inhibitors targeting a selectivity pocket in the active site of human aldo-keto reductase 1B10

Soda, M., Hu, D., Endo, S., Takemura, M., Li, J., Wada, R., Ifuku, S., Zhao, H-T., El-Kabbani, O., Ohta, S., Yamamura, K., Toyooka, N., Hara, A. & Matsunaga, T., 2012, In : European Journal of Medicinal Chemistry. 48, p. 321 - 329 9 p.

Research output: Contribution to journalArticleResearchpeer-review

141 Citations (Scopus)

Development of a sea anemone toxin as an immunomodulator for therapy of autoimmune diseases

Chi, V., Pennington, M. W., Norton, R. S., Tarcha, E. J., Londono, L. M., Sims-Fahey, B., Upadhyay, S. K., Lakey, J. T., Iadonato, S., Wulff, H., Beeton, C. & Chandy, K. G., 2012, In : Toxicon : official journal of the International Society on Toxinology. 59, 4, p. 529 - 546 18 p.

Research output: Contribution to journalArticleResearchpeer-review

40 Citations (Scopus)

Distinct disulfide isomers of u-conotoxins KIIIA and KIIIB block voltage-gated sodium channels

Khoo, K. K., Gupta, K., Green, B. R., Zhang, M-M., Watkins, M., Olivera, B. M., Balaram, P., Yoshikami, D., Bulaj, G. & Norton, R. S., 2012, In : Biochemistry. 51, 49, p. 9826 - 9835 10 p.

Research output: Contribution to journalArticleResearchpeer-review

29 Citations (Scopus)

Enhanced extravasation, stability and in vivo cardiac gene silencing via in situ siRNA-albumin conjugation

Lau, S., Graham, B., Cao, N., Boyd, B. J., Pouton, C. W. & White, P. J., 2012, In : Molecular Pharmaceutics. 9, 1, p. 71 - 80 10 p.

Research output: Contribution to journalArticleResearchpeer-review

15 Citations (Scopus)

Expression and isotopic labelling of the potassium channel blocker ShK toxin as a thioredoxin fusion protein in bacteria

Chang, S. C., Galea, C., Leung, E. W. W., Tajhya, R. B., Beeton, C., Pennington, M. W. & Norton, R. S., 2012, In : Toxicon : official journal of the International Society on Toxinology. 60, 5, p. 840 - 850 11 p.

Research output: Contribution to journalArticleResearchpeer-review

15 Citations (Scopus)

Facile, divergent route to bis-Zn(II)dipicolylamine type chemosensors for pyrophosphate

Pathberiya, L. G., Barlow, N., Nguyen, T. B. T., Graham, B. & Tuck, K. L., 2012, In : Tetrahedron. 68, 46, p. 9435 - 9439 5 p.

Research output: Contribution to journalArticleResearchpeer-review

38 Citations (Scopus)

Glucagon-like peptide-1 receptor dimerization differentially regulates agonist signaling but does not affect small molecule allostery

Harikumar, K. G., Wootten, D. L., Pinon, D. I., Koole, C. R., Ball, A. M., Furness, S. GB., Graham, B., Dong, M., Christopoulos, A., Miller, L. J. & Sexton, P. M., 2012, In : Proceedings of the National Academy of Sciences. 109, 45, p. 18607 - 18612 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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33 Citations (Scopus)

Homobivalent ligands of the atypical antipsychotic clozapine: Design, synthesis, and pharmacological evaluation

McRobb, F. M., Crosby, I. T., Yuriev, E., Lane, J. R. D. & Capuano, B., 2012, In : Journal of Medicinal Chemistry. 55, 4, p. 1622 - 1634 13 p.

Research output: Contribution to journalArticleResearchpeer-review

59 Citations (Scopus)

Identification of compounds with anti-proliferative activity against Trypanosoma brucei brucei strain 427 by a whole cell viability based HTS campaign

Sykes, M. L., Baell, J. B., Kaiser, M., Chatelain, E., Moawad, S. R., Ganame, D., Ioset, J. R. & Avery, V. M., 2012, In : PLoS Neglected Tropical Diseases. 6, 11, 14 p., e1896.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
9 Citations (Scopus)

Improved synthesis of 14-hydroxy opioid pharmaceuticals and intermediates

Orbell, G. B. & Scammells, P. J., 2012, In : RSC Advances. 2, 30, p. 11318 - 11325 8 p.

Research output: Contribution to journalArticleResearchpeer-review

8 Citations (Scopus)

Inhibition of human aldose reductase-like protein (AKR1B10) by a- and y-mangostins, major components of pericarps of mangosteen

Soda, M., Endo, S., Matsunaga, T., Zhao, H-T., El-Kabbani, O., Iinuma, M., Yamamura, K. & Hara, A., 2012, In : Biological & Pharmaceutical Bulletin. 35, 11, p. 2075 - 2080 6 p.

Research output: Contribution to journalArticleResearchpeer-review

12 Citations (Scopus)

Insulin-like growth factor binding protein-2: NMR analysis and structural characterization of the N-terminal domain

Galea, C., Mobli, M., McNeil, K. A., Mulhern, T. D., Wallace, J. C., King, G. F., Forbes, B. & Norton, R. S., 2012, In : Biochimie. 94, 3, p. 608 - 616 9 p.

Research output: Contribution to journalArticleResearchpeer-review

94 Citations (Scopus)

Insulin-like growth factor binding proteins: a structural perspective

Forbes, B., McCarthy, P. & Norton, R. S., 2012, In : Frontiers in Endocrinology. 3, 38, p. 1 - 13 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
19 Citations (Scopus)

Lipid interactions of the malaria antigen merozoite surface protein 2

MacRaild, C. A., Pedersen, M. O., Anders, R. F. & Norton, R. S., 2012, In : Biochimica et Biophysica Acta - Biomembranes. 1818, 11, p. 2572 - 2578 7 p.

Research output: Contribution to journalArticleResearchpeer-review

65 Citations (Scopus)

Macrophage mineralocorticoid receptor signaling plays a key role in aldosterone-independent cardiac fibrosis

Bienvenue, L., Morgan, J., Rickard, A. J., Tesch, G. H., Cranston, G., Fletcher, E. V., Delbridge, L. M. D. & Young, M. J., 2012, In : Endocrinology. 153, 7, p. 3416 - 3425 10 p.

Research output: Contribution to journalArticleResearchpeer-review

114 Citations (Scopus)

Modeling biological activities of nanoparticles

Epa, C., Burden, F. R., Tassa, C., Weissleder, R., Shaw, S. & Winkler, D. A., 2012, In : Nano Letters. 12, 11, p. 5808 - 5812 5 p.

Research output: Contribution to journalArticleResearchpeer-review