Research Output 1977 2019

Filter
Article
2013
7 Citations (Scopus)

Characterization of rabbit morphine 6-dehydrogenase and two NAD+-dependent 3a(17b)-hydroxysteroid dehydrogenases

Endo, S., Matsunaga, T., Fujimoto, A., Kumada, S., Arai, Y., Miura, Y., Mikamo, H., El-Kabbani, O., Yamano, S., Iinuma, M. & Hara, A., 2013, In : Archives of Biochemistry and Biophysics. 529, 2, p. 131 - 139 9 p.

Research output: Contribution to journalArticleResearchpeer-review

32 Citations (Scopus)

Characterization of the novel broad-spectrum kinase inhibitor CTx-0294885 as an affinity reagent for mass spectrometry-based kinome profiling

Zhang, L., Holmes, I. P., Hochgrafe, F., Walker, S. R., Ali, N. A., Humphrey, E. S., Wu, J., de Silva, M., Kersten, W. J. A., Connor, T., Falk, H., Allan, L., Street, I. P., Bentley, J. D., Pilling, P. A., Monahan, B., Peat, T. & Daly, R. J., 2013, In : Journal of Proteome Research. 12, 7, p. 3104 - 3116 13 p.

Research output: Contribution to journalArticleResearchpeer-review

14 Citations (Scopus)

Comparative sequence, structure and redox analyses of Klebsiella pneumoniae DsbA show that anti-virulence target DsbA enzymes fall into distinct classes

Kurth, F., Rimmer, K., Premkumar, L., Mohanty, B., Duprez, W., Halili, M. A., Shouldice, S. R., Heras, B., Fairlie, D. P., Scanlon, M. & Martin, J. L., 2013, In : PLoS ONE. 8, 11, p. 1 - 15 15 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
6 Citations (Scopus)

Computational identification of epitopes in the glycoproteins of novel bunyavirus (SFTS virus) recognized by a human monoclonal antibody (MAb 4-5)

Zhang, W., Zeng, X., Zhang, L., Peng, H., Jiao, Y., Zeng, J. & Treutlein, H. R., 2013, In : Journal of Computer-Aided Molecular Design. 27, 6, p. 539 - 550 12 p.

Research output: Contribution to journalArticleResearchpeer-review

9 Citations (Scopus)

Computational modeling and prediction of the complex time-dependent phase behavior of lyotropic liquid crystals under in meso crystallization conditions

Le, T. C., Conn, C. E., Burden, F. R. & Winkler, D. A., 2013, In : Crystal Growth and Design. 13, 3, p. 1267-1276 10 p.

Research output: Contribution to journalArticleResearchpeer-review

10 Citations (Scopus)

Defining the interaction of perforin with calcium and the phospholipid membrane

Traore, D. A. K., Brennan, A. J., Law, R. H. P., Dogovski, C., Perugini, M. A., Lukoyanova, N., Leung, E. W. W., Norton, R. S., Lopez, J., Browne, K. A., Yagita, H., Lloyd, G., Ciccone, A., Verschoor, S., Trapani, J. A., Whisstock, J. & Voskoboinik, I., 2013, In : Biochemical Journal. 456, 3, p. 323 - 335 13 p.

Research output: Contribution to journalArticleResearchpeer-review

9 Citations (Scopus)

De novo design and synthesis of a mu-conotoxin KIIIA peptidomimetic

Brady, R., Zhang, M., Gable, R. W., Norton, R. S. & Baell, J. B., 2013, In : Bioorganic and Medicinal Chemistry Letters. 23, 17, p. 4892 - 4895 4 p.

Research output: Contribution to journalArticleOtherpeer-review

15 Citations (Scopus)

Design, synthesis, characterisation and in vitro studies of hydrophilic, colloidally stable, 64Cu(II)-labelled, ultra-small iron oxide nanoparticles in a range of human cell lines

Pombo-Garcia, K., Zarschler, K., Barreto Solano, J. A., Hesse, J., Spiccia, L., Graham, B. & Stephan, H., 2013, In : RSC Advances. 3, 44, p. 22443 - 22454 12 p.

Research output: Contribution to journalArticleResearchpeer-review

23 Citations (Scopus)

Design and evaluation of the performance of an NMR screening fragment library

Doak, B. C., Morton, C. J., Simpson, J. S. & Scanlon, M., 2013, In : Australian Journal of Chemistry. 66, 12, p. 1465-1472 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
5 Citations (Scopus)

Detection and prevention of aggregation-based false positives in STD-NMR-based fragment screening

Vom, A., Headey, S. J., Wang, G., Capuano, B., Yuriev, E., Scanlon, M. & Simpson, J. S., 2013, In : Australian Journal of Chemistry. 66, 12, p. 1518 - 1524 7 p.

Research output: Contribution to journalArticleResearchpeer-review

17 Citations (Scopus)

Development of inhibitors of Plasmodium falciparum apical membrane antigen 1 based on fragment screening

Lim, S. S., Debono, C., MacRaild, C. A., Chandrashekaran, I. R., Dolezal, O., Anders, R. F., Simpson, J. S., Scanlon, M., Devine, S., Scammells, P. J. & Norton, R. S., 2013, In : Australian Journal of Chemistry. 66, 12, p. 1530 - 1536 7 p.

Research output: Contribution to journalArticleResearchpeer-review

53 Citations (Scopus)

Development of M1 mAChR allosteric and bitopic ligands: Prospective therapeutics for the treatment of cognitive deficits

Davie, B. J., Christopoulos, A. & Scammells, P. J., 2013, In : ACS Chemical Neuroscience. 4, 7, p. 1026 - 1048 23 p.

Research output: Contribution to journalArticleResearchpeer-review

42 Citations (Scopus)

Dicarba alpha-conotoxin Vc1.1 analogues with differential selectivity for nicotinic acetylcholine and GABA(B) receptors

Van Lierop, B. J., Robinson, S., Kompella, S. N., Belgi, A., McArthur, J. R., Hung, A., MacRaild, C. A., Adams, D. J., Norton, R. S. & Robinson, A. J., 2013, In : ACS Chemical Biology. 8, 8, p. 1815 - 1821 7 p.

Research output: Contribution to journalArticleResearchpeer-review

42 Citations (Scopus)

Discovery of potent and selective benzothiazole hydrazone inhibitors of Bcl-XL

Sleebs, B., Kersten, W. J. A., Kulasegaram, S., Nikolakopoulos, G., Hatzis, E., Moss, R. M., Parisot, J. P., Yang, H., Czabotar, P. E., Fairlie, W. D., Lee, E. F., Adams, J. M., Chen, L., van Delft, M. F., Lowes, K. N., Wei, A., Huang, D. CS., Colman, P. M., Street, I. P., Baell, J. B. & 2 others, Watson, K. G. & Lessene, G., 2013, In : Journal of Medicinal Chemistry. 56, 13, p. 5514 - 5540 27 p.

Research output: Contribution to journalArticleResearchpeer-review

16 Citations (Scopus)

Distinct binding properties of TIAR RRMs and linker region

Kim, H., Headey, S. J., Yoga, Y. M. K., Scanlon, M., Gorospe, M., Wilce, M. C. J. & Wilce, J. A., 2013, In : RNA Biology. 10, 4, p. 579 - 589 11 p.

Research output: Contribution to journalArticleResearchpeer-review

28 Citations (Scopus)

Drug discovery and human African trypanosomiasis: A disease less neglected?

Ferrins, L., Rahmani, R. S. & Baell, J. B., 2013, In : Future Medicinal Chemistry. 5, 15, p. 1801 - 1841 41 p.

Research output: Contribution to journalArticleResearchpeer-review

4 Citations (Scopus)

Effect of linker length and composition on heterobivalent ligand-mediated receptor cross-talk between the A1 adenosine and beta2 adrenergic receptors

Barlow, N., Baker, S. P. & Scammells, P. J., 2013, In : ChemMedChem. 8, 12, p. 2036 - 2046 11 p.

Research output: Contribution to journalArticleResearchpeer-review

11 Citations (Scopus)

Electrochemical surface-enhanced Raman spectroscopy (E-SERS) of novel biodegradable ionic liquids

Harroun, S. G., Abraham, T. J., Prudhoe, C., Zhang, Y., Scammells, P. J., Brosseau, C. L., Pye, C. C. & Singer, R. D., 2013, In : Physical Chemistry Chemical Physics. 15, 44, p. 19205 - 19212 8 p.

Research output: Contribution to journalArticleResearchpeer-review

13 Citations (Scopus)

Exploring the chemical space around 8-mercaptoguanine as a route to new inhibitors of the folate biosynthesis enzyme HPPK

Chhabra, S., Barlow, N., Dolezal, O., Hattarki, M., Newman, J., Peat, T., Graham, B. & Swarbrick, J. D., 2013, In : PLoS ONE. 8, 4, 15 p., e59535.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
2 Citations (Scopus)

Fragment screening on Staphylococcus aureus HPPK - A folate pathway target

Chhabra, S., Dolezal, O., Hattarki, M., Peat, T., Simpson, J. S. & Swarbrick, J. D., 2013, In : Australian Journal of Chemistry. 66, 12, p. 1537 - 1543 7 p.

Research output: Contribution to journalArticleResearchpeer-review

39 Citations (Scopus)

Gadolinium(III) spin labels for high-sensitivity distance measurements in transmembrane helices

Matalon, E., Huber, T., Hagelueken, G., Graham, B., Frydman, V., Feintuch, A., Otting, G. & Goldfarb, D., 2013, In : Angewandte Chemie - International Edition. 52, 45, p. 11831 - 11834 4 p.

Research output: Contribution to journalArticleResearchpeer-review

16 Citations (Scopus)

Glyceride lipid formulations: Molecular dynamics modeling of phase behavior during dispersion and molecular interactions between drugs and excipients

Warren, D., King, D. T., Benameur, H., Pouton, C. W. & Chalmers, D. K., 2013, In : Pharmaceutical Research. 30, 12, p. 3238 - 3253 16 p.

Research output: Contribution to journalArticleResearchpeer-review

5 Citations (Scopus)

Interrogating fragments using a protein thermal shift assay

McMahon, R. M., Scanlon, M. & Martin, J. L., 2013, In : Australian Journal of Chemistry. 66, 12, p. 1502 - 1506 5 p.

Research output: Contribution to journalArticleResearchpeer-review

14 Citations (Scopus)

Intracellular trafficking of the KV1.3 potassium channel is regulated by the prodomain of a matrix metalloprotease

Nguyen, H. M., Galea, C., Schmunk, G., Smith, B. J., Edwards, R. A., Norton, R. S. & Chandy, K. G., 2013, In : Journal of Biological Chemistry. 288, 9, p. 6451 - 6464 14 p.

Research output: Contribution to journalArticleResearchpeer-review

24 Citations (Scopus)

L-aminoacyl-triazine derivatives are isoform-selective PI3KB inhibitors that target nonconserved Asp862 of PI3KB

Pinson, J-A., Zheng, Z., Miller, M. S., Chalmers, D. K., Jennings, I. & Thompson, P., 2013, In : ACS Medicinal Chemistry Letters. 4, 2, p. 206 - 210 5 p.

Research output: Contribution to journalArticleResearchpeer-review

59 Citations (Scopus)

Lanthanide tags for site-specific ligation to an unnatural amino acid and generation of pseudocontact shifts in proteins

Loh, C. T., Ozawa, K., Tuck, K. L., Barlow, N., Huber, T., Otting, G. & Graham, B., 2013, In : Bioconjugate Chemistry. 24, 2, p. 260 - 268 9 p.

Research output: Contribution to journalArticleResearchpeer-review

170 Citations (Scopus)

Latest developments in molecular docking: 2010-2011 in review

Yuriev, E. & Ramsland, P. A., 2013, In : Journal of Molecular Recognition. 26, 5, p. 215 - 239 25 p.

Research output: Contribution to journalArticleResearchpeer-review

14 Citations (Scopus)

Mammalian neuronal sodium channel blocker u-conotoxin BuIIIB has a structured N-terminus that influences potency

Kuang, Z., Zhang, M-M., Gupta, K., Gajewiak, J., Gulyas, J., Balaram, P., Rivier, J. E., Olivera, B. M., Yoshikami, D., Bulaj, G. & Norton, R. S., 2013, In : ACS Chemical Biology. 8, 6, p. 1344 - 1351 8 p.

Research output: Contribution to journalArticleResearchpeer-review

12 Citations (Scopus)

Mechanisms of PI3Kb-selective inhibition revealed by reciprocal mutagenesis

Zheng, Z., Miller, M. S., Jennings, I. & Thompson, P., 2013, In : ACS Chemical Biology. 8, 4, p. 679 - 683 5 p.

Research output: Contribution to journalArticleResearchpeer-review

3 Citations (Scopus)

Mesenchymal stromal cell turnover in the normal adult lung revisited

Seyed-Razavi, Y., Williams, B., Winkler, D. A. & Bertoncello, I., 2013, In : American Journal of Physiology - Lung Cellular and Molecular Physiology. 305, 9, p. 635 - 641 7 p.

Research output: Contribution to journalArticleResearchpeer-review

2 Citations (Scopus)

Modulation of activity and inhibitor sensitivity of rabbit aldose reductase-like protein (AKR1B19) by oxidized glutathione and SH-reagents

Endo, S., Fujimoto, A., Kumada, S., Matsunaga, T., Ohno, S., Mano, J., Tajima, K., El-Kabbani, O. & Hara, A., 2013, In : Chemico-Biological Interactions. 202, p. 146 - 152 7 p.

Research output: Contribution to journalArticleResearchpeer-review

21 Citations (Scopus)

Molecular basis for the increased polymyxin susceptibility of Klebsiella pneumoniae strains with under-acylated lipid A

Velkov, T., Soon, R. L-X., Huang, J. X., Cooper, M. A., Azad, M. A. K., Baker, M. A., Thompson, P., Roberts, K. D., Nation, R. L., Clements, A., Strugnell, R. A. & Li, J., 2013, In : Innate Immunity. 19, 3, p. 265 - 277 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
9 Citations (Scopus)

Molecular determinants of the substrate specificity of the complement-initiating protease, C1r

Wijeyewickrema, L. C., Yongqing, T., Tran, P. T., Thompson, P., Viljoen, J. E., Coetzer, T. H., Duncan, R. C., Kass, I., Buckle, A. M. & Pike, R. N., 2013, In : Journal of Biological Chemistry. 288, 22, p. 15571 - 15580 10 p.

Research output: Contribution to journalArticleResearchpeer-review

19 Citations (Scopus)
41 Citations (Scopus)

Novel conjugated quinoline-indoles compromise Plasmodium falciparum mitochondrial function and show promising antimalarial activity

Teguh, S., Klonis, N., Duffy, S., Lucantoni, L., Avery, V. M., Hutton, C. A., Baell, J. B. & Tilley, L., 2013, In : Journal of Medicinal Chemistry. 56, 15, p. 6200 - 6215 16 p.

Research output: Contribution to journalArticleResearchpeer-review

33 Citations (Scopus)

Opposing auxiliary conformations produce the same torquoselectivity in an oxazolidinone-directed Nazarov cyclization

Flynn, B. L., Manchala, N. & Krenske, E. H., 2013, In : Journal of the American Chemical Society. 135, 24, p. 9156 - 9163 8 p.

Research output: Contribution to journalArticleResearchpeer-review

44 Citations (Scopus)

PAINS: Relevance to tool compound discovery and fragment-based screening

Baell, J. B., Ferrins, L., Falk, H. & Nikolakopoulos, G., 2013, In : Australian Journal of Chemistry. 66, 12, p. 1483 - 1494 12 p.

Research output: Contribution to journalArticleResearchpeer-review

52 Citations (Scopus)

Parallel screening of low molecular weight fragment libraries: Do differences in methodology affect hit identification?

Wielens, J., Headey, S. J., Rhodes, D. I., Mulder, R. J., Dolezal, O., Deadman, J. J., Newman, J., Chalmers, D. K., Parker, M. W., Peat, T. & Scanlon, M., 2013, In : Journal of Biomolecular Screening. 18, 2, p. 147 - 159 13 p.

Research output: Contribution to journalArticleResearchpeer-review

48 Citations (Scopus)

Pathophysiological roles of aldo-keto reductases (AKR1C1 and AKR1C3) in development of cisplatin resistance in human colon cancers

Matsunaga, T., Hojo, A., Yamane, Y., Endo, S., El-Kabbani, O. & Hara, A., 2013, In : Chemico-Biological Interactions. 202, p. 234 - 242 9 p.

Research output: Contribution to journalArticleResearchpeer-review

50 Citations (Scopus)

Pharmacokinetics of four different brands of colistimethate and formed colistin in rats

He, H., Li, J. C., Nation, R. L., Jacob, J., Chen, G., Lee, H. J., Tsuji, B., Thompson, P., Roberts, K. D., Velkov, T. & Li, J., 2013, In : Journal of Antimicrobial Chemotherapy. 68, 10, p. 2311 - 2317 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
183 Citations (Scopus)

Pharmacology of polymyxins: New insights into an 'old' class of antibiotics

Velkov, T., Roberts, K. D., Nation, R. L., Thompson, P. & Li, J., 2013, In : Future Microbiology. 8, 6, p. 711 - 724 14 p.

Research output: Contribution to journalArticleResearchpeer-review

17 Citations (Scopus)

Polymyxins and analogues bind to ribosomal RNA and interfere with eukaryotic translation in vitro

McCoy, L. S., Roberts, K. D., Nation, R. L., Thompson, P., Velkov, T., Li, J. & Tor, Y., 2013, In : ChemBioChem. 14, 16, p. 2083 - 2086 4 p.

Research output: Contribution to journalArticleOtherpeer-review

4 Citations (Scopus)

Potent agonists of a hematopoietic stem cell cytokine receptor, c-Mpl

Tarasova, A., Haylock, D. N., Meagher, L., Be, C. L., White, J., Nilsson, S. K., Andrade, J., Cartledge, K. & Winkler, D. A., 2013, In : ChemMedChem. 8, 5, p. 763-771 9 p.

Research output: Contribution to journalArticleResearchpeer-review

6 Citations (Scopus)

Potent inhibitors of phosphatidylinositol 3 (PI3) kinase that have antiproliferative activity only when delivered as prodrug forms

O'Brien, N. J., Amran, S. I., Medan, J., Cleary, B., Deady, L., Jennings, I., Thompson, P. & Abbott, B. M., 2013, In : ChemMedChem. 8, 6, p. 914 - 918 5 p.

Research output: Contribution to journalArticleResearchpeer-review

12 Citations (Scopus)

Predicting the complex phase behavior of self-assembling drug delivery nanoparticles

Le, T. C., Mulet, X., Burden, F. R. & Winkler, D. A., 2013, In : Molecular Pharmaceutics. 10, 4, p. 1368-1377 10 p.

Research output: Contribution to journalArticleResearchpeer-review

4 Citations (Scopus)

Predicting the effect of lipid structure on mesophase formation during in meso crystallization

Le, T. C., Conn, C. E., Burden, F. R. & Winkler, D. A., 2013, In : Crystal Growth and Design. 13, 7, p. 3126 - 3137 12 p.

Research output: Contribution to journalArticleResearchpeer-review

13 Citations (Scopus)

Probing structural requirements of positive allosteric modulators of the M4 muscarinic receptor

Huynh, T., Valant, C., Crosby, I. T., Sexton, P., Christopoulos, A. & Capuano, B., 2013, In : Journal of Medicinal Chemistry. 56, 20, p. 8196 - 8200 5 p.

Research output: Contribution to journalArticleResearchpeer-review

9 Citations (Scopus)

Pyridinylquinazolines selectively inhibit human methionine aminopeptidase-1 in cells

Zhang, F., Bhat, S., Gabelli, S., Chen, X., Miller, M. S., Nacev, B. A., Cheng, Y. L., Meyers, D. J., Tenney, K., Shim, J. S., Crews, P., Amzel, L. M., Ma, D. & Liu, J., 2013, In : Journal of Medicinal Chemistry. 56, 10, p. 3996 - 4016 21 p.

Research output: Contribution to journalArticleResearchpeer-review

7 Citations (Scopus)

Rabbit 3-hydroxyhexobarbital dehydrogenase is a NADPH-preferring reductase with broad substrate specificity for ketosteroids, prostaglandin D2, and other endogenous and xenobiotic carbonyl compounds

Endo, S., Matsunaga, T., Matsumoto, A., Arai, Y., Ohno, S., El-Kabbani, O., Tajima, K., Bunai, Y., Yamano, S., Hara, A. & Kitade, Y., 2013, In : Biochemical Pharmacology. 86, 9, p. 1366 - 1375 10 p.

Research output: Contribution to journalArticleResearchpeer-review

11 Citations (Scopus)

Regioselective synthesis of 5- and 6-methoxybenzimidazole-1,3,5-triazines as inhibitors of phosphoinositide 3-kinase

Miller, M. S., Pinson, J-A., Zheng, Z., Jennings, I. & Thompson, P., 2013, In : Bioorganic and Medicinal Chemistry Letters. 23, 3, p. 802 - 805 4 p.

Research output: Contribution to journalArticleResearchpeer-review