Research Output 1977 2019

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2018

Fluorescently Labeled Morphine Derivatives for Bioimaging Studies

Lam, R., Gondin, A. B., Canals, M., Kellam, B., Briddon, S. J., Graham, B. & Scammells, P. J., 8 Feb 2018, In : Journal of Medicinal Chemistry. 61, 3, p. 1316-1329 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Fragment-based discovery of inhibitors of the bacterial DnaG-SSB interaction

Chilingaryan, Z., Headey, S. J., Lo, A. T. Y., Xu, Z. Q., Otting, G., Dixon, N. E., Scanlon, M. J. & Oakley, A. J., 1 Mar 2018, In : Antibiotics. 7, 1, p. 1-12 12 p., 14.

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Genetically encoded amino acids with tert-butyl and trimethylsilyl groups for site-selective studies of proteins by NMR spectroscopy

Loh, C. T., Adams, L. A., Graham, B. & Otting, G., 1 Aug 2018, In : Journal of Biomolecular NMR. 71, 4, p. 287-293 7 p.

Research output: Contribution to journalArticleResearchpeer-review

High-Throughput Assessment and Modeling of a Polymer Library Regulating Human Dental Pulp-Derived Stem Cell Behavior

Rasi Ghaemi, S., Delalat, B., Gronthos, S., Alexander, M. R., Winkler, D. A., Hook, A. L. & Voelcker, N. H., 14 Nov 2018, In : ACS Applied Materials and Interfaces. 10, 45, p. 38739-38748 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Identification, chemical synthesis, structure, and function of a new KV1 channel blocking peptide from Oulactis sp.

Sunanda, P., Krishnarjuna, B., Peigneur, S., Mitchell, M. L., Estrada, R., Villegas-Moreno, J., Pennington, M. W., Tytgat, J. & Norton, R. S., 1 Jul 2018, In : Peptide Science. 110, 4, 10 p., e24073.

Research output: Contribution to journalArticleResearchpeer-review

Identification of novel antivirals inhibiting recognition of Venezuelan equine encephalitis virus capsid protein by the Importin α/β1 heterodimer through high-throughput screening

Thomas, D. R., Lundberg, L., Pinkham, C., Shechter, S., DeBono, A., Baell, J., Wagstaff, K. M., Hick, C. A., Kehn-Hall, K. & Jans, D. A., 1 Mar 2018, In : Antiviral Research. 151, p. 8-19 12 p.

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Impact of Dynamically Exposed Polarity on Permeability and Solubility of Chameleonic Drugs beyond the Rule of 5

Rossi Sebastiano, M., Doak, B. C., Backlund, M., Poongavanam, V., Over, B., Ermondi, G., Caron, G., Matsson, P. & Kihlberg, J., 10 May 2018, In : Journal of Medicinal Chemistry. 61, 9, p. 4189-4202 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Inhibition of Diverse DsbA Enzymes in Multi-DsbA Encoding Pathogens

Totsika, M., Vagenas, D., Paxman, J. J., Wang, G., Dhouib, R., Sharma, P., Martin, J. L., Scanlon, M. J. & Heras, B., 1 Sep 2018, In : Antioxidants and Redox Signaling. 29, 7, p. 653-666 14 p.

Research output: Contribution to journalArticleResearchpeer-review

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Lanthanide complexes for luminescence-based sensing of low molecular weight analytes

Aulsebrook, M. L., Graham, B., Grace, M. R. & Tuck, K. L., 2018, In : Coordination Chemistry Reviews. 375, p. 191-220 30 p.

Research output: Contribution to journalArticleResearchpeer-review

Linker chemistry dictates the delivery of a phototoxic organometallic rhenium(i) complex to human cervical cancer cells from core crosslinked star polymer nanoparticles

Yu, S. H., Patra, M., Ferrari, S., Ramirez Garcia, P., Veldhuis, N. A., Kaminskas, L. M., Graham, B., Quinn, J. F., Whittaker, M. R., Gasser, G. & Davis, T. P., 29 Oct 2018, In : Journal of Materials Chemistry B. 6, 47, p. 7805-7810 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Liquid Assisted Grinding for the N-Demethylation of Alkaloids

Awalt, J. K., Scammells, P. J. & Singer, R. D., 6 Aug 2018, In : ACS Sustainable Chemistry and Engineering. 6, 8, p. 10052-10057 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Methionine ameliorates polymyxin-induced nephrotoxicity by attenuating cellular oxidative stress

Azad, M. A. K., Sivanesan, S., Wang, J., Chen, K., Nation, R. L., Thompson, P. E., Roberts, K. D., Velkov, T. & Li, J., 1 Jan 2018, In : Antimicrobial Agents and Chemotherapy. 62, 1, 9 p., e01254.

Research output: Contribution to journalArticleResearchpeer-review

Modified Gold Nanoparticles for the Temperature-Dependent Colorimetric Detection of Mercury and Methylmercury

Aulsebrook, M. L., Watkins, E., Grace, M. R., Graham, B. & Tuck, K. L., 21 Feb 2018, In : ChemistrySelect. 3, 7, p. 2088-2091 4 p.

Research output: Contribution to journalArticleResearchpeer-review

Multivariate analysis of ToF-SIMS data using mass segmented peak lists

Madiona, R., Welch, N. G., Russell, S., Winkler, D., Scoble, J. A., Muir, B. W. & Pigram, P. J., 1 Jul 2018, In : Surface and Interface Analysis. 50, 7, p. 713-728 16 p.

Research output: Contribution to journalArticleResearchpeer-review

Novel agrochemical conjugates with self-assembling behaviour

Liu, Q., Graham, B., Hawley, A., Dong, Y. D. & Boyd, B. J., 15 Feb 2018, In : Journal of Colloid and Interface Science. 512, p. 369-378 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Peptide therapeutics from venom: Current status and potential

Pennington, M. W., Czerwinski, A. & Norton, R. S., 1 Jun 2018, In : Bioorganic and Medicinal Chemistry. 26, 10, p. 2738-2758 21 p.

Research output: Contribution to journalArticleResearchpeer-review

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Prediction of Broad-Spectrum Pathogen Attachment to Coating Materials for Biomedical Devices

Mikulskis, P., Hook, A., Dundas, A. A., Irvine, D., Sanni, O., Anderson, D., Langer, R., Alexander, M. R., Williams, P. & Winkler, D. A., 10 Jan 2018, In : ACS Applied Materials and Interfaces. 10, 1, p. 139-149 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Probing the binding site of novel selective positive allosteric modulators at the M1 muscarinic acetylcholine receptor

Khajehali, E., Valant, C., Jörg, M., Tobin, A. B., Conn, P. J., Lindsley, C. W., Sexton, P. M., Scammells, P. J. & Christopoulos, A., 1 Aug 2018, In : Biochemical Pharmacology. 154, p. 243-254 12 p.

Research output: Contribution to journalArticleResearchpeer-review

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Probing the correlation between insulin activity and structural stability through introduction of the rigid A6 –A11 bond

Ong, S. C., Belgi, A., Van Lierop, B., Delaine, C., Andrikopoulos, S., MacRaild, C. A., Norton, R. S., Haworth, N. L., Robinson, A. J. & Forbes, B. E., 27 Jul 2018, In : Journal of Biological Chemistry. 293, 30, p. 11928-11943 16 p.

Research output: Contribution to journalArticleResearchpeer-review

Production, biophysical characterization and initial crystallization studies of the N- and C-terminal domains of DsbD, an essential enzyme in Neisseria meningitidis

Smith, R. P., Whitten, A. E., Paxman, J. J., Kahler, C. M., Scanlon, M. J. & Heras, B., 1 Jan 2018, In : Acta Crystallographica. Section F: Structural Biology Communications. 74, 1, p. 31-38 8 p.

Research output: Contribution to journalArticleResearchpeer-review

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Protease-activated receptor-2 in endosomes signals persistent pain of irritable bowel syndrome

Jimenez-Vargas, N. N., Pattison, L. A., Zhao, P., Lieu, T., Latorre, R., Jensen, D. D., Castro, J., Aurelio, L., Le, G. T., Flynn, B., Herenbrink, C. K., Yeatman, H. R., Edgington-Mitchell, L., Porter, C. J. H., Halls, M. L., Canals, M., Veldhuis, N. A., Poole, D. P., McLean, P., Hicks, G. A. & 7 othersScheff, N., Chen, E., Bhattacharya, A., Schmidt, B. L., Brierley, S. M., Vanner, S. J. & Bunnett, N. W., 31 Jul 2018, In : Proceedings of the National Academy of Sciences of the United States of America. 115, 31, p. E7438-E7447 10 p.

Research output: Contribution to journalArticleResearchpeer-review

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Quantifying cellular internalization with a fluorescent click sensor

Selby, L. I., Aurelio, L., Yuen, D., Graham, B. & Johnston, A. P. R., 22 Jun 2018, In : ACS Sensors. 3, 6, p. 1182-1189 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Site-Specific Incorporation of Selenocysteine by Genetic Encoding as a Photocaged Unnatural Amino Acid

Welegedara, A. P., Adams, L. A., Huber, T., Graham, B. & Otting, G., 18 Jul 2018, In : Bioconjugate Chemistry. 29, 7, p. 2257-2264 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Small neutral Gd(iii) tags for distance measurements in proteins by double electron-electron resonance experiments

Mahawaththa, M. C., Lee, M. D., Giannoulis, A., Adams, L. A., Feintuch, A., Swarbrick, J. D., Graham, B., Nitsche, C., Goldfarb, D. & Otting, G., 1 Jan 2018, In : Physical Chemistry Chemical Physics. 20, 36, p. 23535-23545 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Sparse QSAR modelling methods for therapeutic and regenerative medicine

Winkler, D. A., 1 Apr 2018, In : Journal of Computer-Aided Molecular Design. 32, 4, p. 497-509 13 p.

Research output: Contribution to journalArticleOtherpeer-review

Spectroscopic Studies on Photoinduced Reactions of the Anticancer Prodrug, trans,trans,trans-[Pt(N3)2(OH)2(py)2]

Vernooij, R. R., Joshi, T., Horbury, M. D., Graham, B., Izgorodina, E. I., Stavros, V. G., Sadler, P. J., Spiccia, L. & Wood, B. R., 17 Apr 2018, In : Chemistry - A European Journal. 24, 22, p. 5790-5803 14 p.

Research output: Contribution to journalArticleResearchpeer-review

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Sputum Active Polymyxin Lipopeptides: Activity against Cystic Fibrosis Pseudomonas aeruginosa Isolates and Their Interactions with Sputum Biomolecules

Schneider-Futschik, E. K., Paulin, O. K. A., Hoyer, D., Roberts, K. D., Ziogas, J., Baker, M. A., Karas, J., Li, J. & Velkov, T., 11 May 2018, In : ACS Infectious Diseases. 4, 5, p. 646-655 10 p.

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Structural and biochemical insights into the disulfide reductase mechanism of DsbD, an essential enzyme for neisserial pathogens

Smith, R. P., Mohanty, B., Mowlaboccus, S., Paxman, J. J., Williams, M. L., Headey, S. J., Wang, G., Subedi, P., Doak, B. C., Kahler, C. M., Scanlon, M. J. & Heras, B., 1 Jan 2018, In : Journal of Biological Chemistry. 293, 43, p. 16559-16571 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Structural basis for antibody targeting of the broadly expressed microbial polysaccharide poly-N-acetylglucosamine

Soliman, C., Walduck, A. K., Yuriev, E., Richards, J. S., Cywes-Bentley, C., Pier, G. B. & Ramsland, P. A., 1 Jan 2018, In : Journal of Biological Chemistry. 293, 14, p. 5079-5089 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Structural basis for the inhibition of poxvirus assembly by the antibiotic rifampicin

Garriga, D., Headey, S., Accurso, C., Gunzburg, M., Scanlon, M. & Coulibaly, F., 14 Aug 2018, In : Proceedings of the National Academy of Sciences of the United States of America. 115, 33, p. 8424-8429 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Structural Determinants for Small-Molecule Activation of Skeletal Muscle AMPK α2β2γ1 by the Glucose Importagog SC4

Ngoei, K. R. W., Langendorf, C. G., Ling, N. X. Y., Hoque, A., Varghese, S., Camerino, M. A., Walker, S. R., Bozikis, Y. E., Dite, T. A., Ovens, A. J., Smiles, W. J., Jacobs, R., Huang, H., Parker, M. W., Scott, J. W., Rider, M. H., Foitzik, R. C., Kemp, B. E., Baell, J. B. & Oakhill, J. S., 21 Jun 2018, In : Cell Chemical Biology. 25, 6, p. 728-737.e9 20 p.

Research output: Contribution to journalArticleResearchpeer-review

Structure, folding and stability of a minimal homologue from Anemonia sulcata of the sea anemone potassium channel blocker ShK

Krishnarjuna, B., MacRaild, C. A., Sunanda, P., Morales, R. A. V., Peigneur, S., Macrander, J., Yu, H. H., Daly, M., Raghothama, S., Dhawan, V., Chauhan, S., Tytgat, J., Pennington, M. W. & Norton, R. S., Jan 2018, In : Peptides. 99, p. 169–178 10 p.

Research output: Contribution to journalArticleResearchpeer-review

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Structure, Function, and Biosynthetic Origin of Octapeptin Antibiotics Active against Extensively Drug-Resistant Gram-Negative Bacteria

Velkov, T., Gallardo-Godoy, A., Swarbrick, J. D., Blaskovich, M. A. T., Elliott, A. G., Han, M., Thompson, P. E., Roberts, K. D., Huang, J. X., Becker, B., Butler, M. S., Lash, L. H., Henriques, S. T., Nation, R. L., Sivanesan, S., Sani, M. A., Separovic, F., Mertens, H., Bulach, D., Seemann, T. & 3 othersOwen, J., Li, J. & Cooper, M. A., 19 Apr 2018, In : Cell Chemical Biology. 25, 4, p. 380-391 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Synthesis, folding, structure and activity of a predicted peptide from the sea anemone Oulactis sp. with an ShKT fold

Krishnarjuna, B., Villegas-Moreno, J., Mitchell, M. L., Csoti, A., Peigneur, S., Amero, C., Pennington, M. W., Tytgat, J., Panyi, G. & Norton, R. S., 1 Aug 2018, In : Toxicon. 150, p. 50-59 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Synthesis and Pharmacological Evaluation of Noscapine-Inspired 5-Substituted Tetrahydroisoquinolines as Cytotoxic Agents

Devine, S. M., Yong, C., Amenuvegbe, D., Aurelio, L., Muthiah, D., Pouton, C., Callaghan, R., Capuano, B. & Scammells, P. J., 27 Sep 2018, In : Journal of Medicinal Chemistry. 61, 18, p. 8444-8456 13 p.

Research output: Contribution to journalArticleResearchpeer-review

The action of a negative allosteric modulator at the dopamine D2 receptor is dependent upon sodium ions

Draper-Joyce, C. J., Verma, R. K., Michino, M., Shonberg, J., Kopinathan, A., Klein Herenbrink, C., Scammells, P. J., Capuano, B., Abramyan, A. M., Thal, D. M., Javitch, J. A., Christopoulos, A., Shi, L. & Lane, J. R., 1 Dec 2018, In : Scientific Reports. 8, 1, 12 p., 1208.

Research output: Contribution to journalArticleResearchpeer-review

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The structural determinants of the bitopic binding mode of a negative allosteric modulator of the dopamine D2 receptor

Draper-Joyce, C. J., Michino, M., Verma, R. K., Klein Herenbrink, C., Shonberg, J., Kopinathan, A., Scammells, P. J., Capuano, B., Thal, D. M., Javitch, J. A., Christopoulos, A., Shi, L. & Lane, J. R., 1 Feb 2018, In : Biochemical Pharmacology. 148, p. 315-328 14 p.

Research output: Contribution to journalArticleResearchpeer-review

The TRIM-NHL protein NHL-2 is a co-factor in the nuclear and somatic RNAi pathways in C. Elegans

Davis, G. M., Tu, S., Anderson, J. WT., Colson, R. N., Gunzburg, M. J., Francisco, M. A., Ray, D., Shrubsole, S. P., Sobotka, J. A., Seroussi, U., Lao, R. X., Maity, T., Wu, M. Z., McJunkin, K., Morris, Q. D., Hughes, T. R., Wilce, J. A., Claycomb, J. M., Weng, Z. & Boag, P. R., 21 Dec 2018, In : eLife. 7, 29 p., e35478.

Research output: Contribution to journalArticleResearchpeer-review

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Transformation of Biopharmaceutical Classification System Class I and III Drugs Into Ionic Liquids and Lipophilic Salts for Enhanced Developability Using Lipid Formulations

Williams, H. D., Ford, L., Lim, S., Han, S., Baumann, J., Sullivan, H., Vodak, D., Igonin, A., Benameur, H., Pouton, C. W., Scammells, P. J. & Porter, C. J. H., 2018, In : Journal of Pharmaceutical Sciences. 107, 1, p. 203–216 14 p.

Research output: Contribution to journalArticleResearchpeer-review

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Trimethylsilyl tag for probing protein–ligand interactions by NMR

Becker, W., Adams, L. A., Graham, B., Wagner, G. E., Zangger, K., Otting, G. & Nitsche, C., 1 Apr 2018, In : Journal of Biomolecular NMR. 70, 4, p. 211-218 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Virtual Screening Against Carbohydrate-Binding Proteins: Evaluation and Application to Bacterial Burkholderia ambifaria Lectin

Dingjan, T., Gillon, É., Imberty, A., Pérez, S., Titz, A., Ramsland, P. A. & Yuriev, E., 24 Sep 2018, In : Journal of Chemical Information and Modeling. 58, 9, p. 1976-1989 14 p.

Research output: Contribution to journalArticleResearchpeer-review

2017

A luminogenic lanthanide-based probe for the highly selective detection of nanomolar sulfide levels in aqueous samples

Aulsebrook, M., Biswas, S., Leaver, F. M., Grace, M. R., Graham, B., Barrios, A. M. & Tuck, K. L., 2017, In : Chemical Communications. 53, 36, p. 4911-4914 4 p.

Research output: Contribution to journalArticleResearchpeer-review

Assessing the anthelmintic activity of pyrazole-5-carboxamide derivatives against Haemonchus contortus

Jiao, Y., Preston, S., Song, H., Jabbar, A., Liu, Y., Baell, J., Hofmann, A., Hutchinson, D., Wang, T., Koehler, A. V., Fisher, G. M., Andrews, K. T., Laleu, B., Palmer, M. J., Burrows, J. N., Wells, T. N. C., Wang, Q. & Gasser, R. B., 31 May 2017, In : Parasites and Vectors. 10, 1, 272.

Research output: Contribution to journalArticleResearchpeer-review

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Characterisation of a novel coumarin-based fluorescent probe for monitoring nitric oxide production in macrophages

Sadek, M., Barzegar Amiri Olia, M., Nowell, C. J., Barlow, N., Schiesser, C. H., Nicholson, S. E. & Norton, R. S., 15 Oct 2017, In : Bioorganic & Medicinal Chemistry. 25, 20, p. 5743–5748 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Characterization of the Polymyxin D Synthetase Biosynthetic Cluster and Product Profile of Paenibacillus polymyxa ATCC 10401

Galea, C. A., Han, M., Zhu, Y., Roberts, K., Wang, J., Thompson, P. E., Li, J. & Velkov, T., 26 May 2017, In : Journal of Natural Products. 80, 5, p. 1264-1274 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Chemical Tagging with tert-Butyl and Trimethylsilyl Groups for Measuring Intermolecular Nuclear Overhauser Effects in a Large Protein–Ligand Complex

Jabar, S., Adams, L. A., Wang, Y., Aurelio, L., Graham, B. & Otting, G., 21 Sep 2017, In : Chemistry - A European Journal. 23, 53, p. 13033-13036 4 p.

Research output: Contribution to journalArticleResearchpeer-review