Institute of Vector Borne Disease (IVbD)

Research Output 1996 2019

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2019

Analysis of cluster-randomized test-negative designs: Cluster-level methods

Jewell, N. P., Dufault, S., Cutcher, Z., Simmons, C. P. & Anders, K. L., 1 Apr 2019, In : Biostatistics. 20, 2, p. 332-346 15 p.

Research output: Contribution to journalArticleResearchpeer-review

Attenuation of a dengue virus replicon by codon deoptimization of nonstructural genes

Manokaran, G., Sujatmoko, McPherson, K. G. & Simmons, C. P., 9 May 2019, In : Vaccine. 37, 21, p. 2857-2863 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Differential suppression of persistent insect specific viruses in trans-infected wMel and wMelPop-CLA Aedes-derived mosquito lines

McLean, B. J., Dainty, K. R., Flores, H. A. & O'Neill, S. L., 15 Jan 2019, In : Virology. 527, p. 141-145 5 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Novel Flavivirus Antiviral That Targets the Host Nuclear Transport Importin α/β1 Heterodimer

Yang, S. N. Y., Atkinson, S. C., Fraser, J. E., Wang, C., Maher, B., Roman, N., Forwood, J. K., Wagstaff, K. M., Borg, N. A. & Jans, D. A., 24 Mar 2019, In : Cells. 8, 3, 15 p., 281.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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The Role of Maternally Acquired Antibody in Providing Protective Immunity Against Nontyphoidal Salmonella in Urban Vietnamese Infants: A Birth Cohort Study

De Alwis, R., Tu, L. T. P., Quynh, N. L. T., Thompson, C. N., Anders, K. L., Van Thuy, N. T., Hieu, N. T., Vi, L. L., Chau, N. V. V., Duong, V. T., Chau, T. T. H., Tuyen, H. T., Nga, T. V. T., Minh, P. V., Tan, T. V., Thu, T. N. H., Nhu, T. D. H., Thwaites, G. E., Simmons, C. & Baker, S., 7 Jan 2019, In : Journal of Infectious Diseases. 219, 2, p. 295-304 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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2018

Baseline characterization of dengue epidemiology in Yogyakarta City, Indonesia, before a randomized controlled trial of Wolbachia for arboviral disease control

Indriani, C., Ahmad, R. A., Wiratama, B. S., Arguni, E., Supriyati, E., Sasmono, R. T., Kisworini, F. Y., Ryan, P. A., O'Neill, S. L., Simmons, C. P., Utarini, A. & Anders, K. L., 1 Jan 2018, In : American Journal of Tropical Medicine and Hygiene. 99, 5, p. 1299-1307 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Cluster-randomized test-negative design trials: A novel and efficient method to assess the efficacy of community-level dengue interventions

Anders, K. L., Cutcher, Z., Kleinschmidt, I., Donnelly, C. A., Ferguson, N. M., Indriani, C., Ryan, P. A., O'Neill, S. L., Jewell, N. P. & Simmons, C. P., 1 Jan 2018, In : American Journal of Epidemiology. 187, 9, p. 2021-2028 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Epidemiological, serological, and virological features of dengue in Nha Trang City, Vietnam

Quyen, D. L., Le, N. T., Van Anh, C. T., Nguyen, N. B., Van Hoang, D., Montgomery, J. L., Kutcher, S. C., Le, N. H., Hien, N. T., Kien, D. T. H., Rabaa, M., O'Neill, S. L., Simmons, C. P., Anh, D. D. & Anders, K. L., 2018, In : American Journal of Tropical Medicine and Hygiene. 98, 2, p. 402-409 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Scaled deployment of Wolbachia to protect the community from dengue and other Aedes transmitted arboviruses

O'Neill, S. L., Ryan, P. A., Turley, A. P., Wilson, G., Retzki, K., Iturbe-Ormaetxe, I., Dong, Y., Kenny, N., Paton, C. J., Ritchie, S. A., Brown-Kenyon, J., Stanford, D., Wittmeier, N., Anders, K. L. & Simmons, C. P., 2018, In : Gates Open Research. 2, 27 p., 36.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Survival analysis with time-dependent covariates subject to missing data or measurement error: Multiple Imputation for Joint Modeling (MIJM)

Moreno-Betancur, M., Carlin, J. B., Brilleman, S. L., Tanamas, S. K., Peeters, A. & Wolfe, R., 1 Oct 2018, In : Biostatistics. 19, 4, p. 479-496 18 p.

Research output: Contribution to journalArticleResearchpeer-review

The AWED trial (Applying Wolbachia to Eliminate Dengue) to assess the efficacy of Wolbachia-infected mosquito deployments to reduce dengue incidence in Yogyakarta, Indonesia: Study protocol for a cluster randomised controlled trial

Anders, K. L., Indriani, C., Ahmad, R. A., Tantowijoyo, W., Arguni, E., Andari, B., Jewell, N. P., Rances, E., O'Neill, S. L., Simmons, C. P. & Utarini, A., 31 May 2018, In : Trials. 19, 1, 16 p., 302.

Research output: Contribution to journalArticleOtherpeer-review

Viral genetic diversity and protective efficacy of a tetravalent dengue vaccine in two phase 3 trials

Juraska, M., Magaret, C. A., Shao, J., Carpp, L. N., Fiore-Gartland, A. J., Benkeser, D., Girerd-Chambaz, Y., Langevin, E., Frago, C., Guy, B., Jackson, N., Hue, K. D. T., Simmons, C. P., Edlefsen, P. T. & Gilbert, P. B., 4 Sep 2018, In : Proceedings of the National Academy of Sciences. 115, 36, p. E8378-E8387 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Wolbachia infection alters the relative abundance of resident bacteria in adult Aedes aegypti mosquitoes, but not larvae

Audsley, M. D., Seleznev, A., Joubert, D. A., Woolfit, M., O'Neill, SL. & McGraw, E. A., 1 Jan 2018, In : Molecular Ecology. 27, 1, p. 297-309 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Zika vaccines and therapeutics: Landscape analysis and challenges ahead

Wilder-Smith, A., Vannice, K., Durbin, A., Hombach, J., Thomas, S. J., Thevarjan, I. & Simmons, C. P., 6 Jun 2018, In : BMC Medicine. 16, 1, 15 p., 84.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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2017

A highly stable blood meal alternative for rearing Aedes and Anopheles mosquitoes

Baughman, T., Peterson, C., Ortega, C., Preston, S. R., Paton, C., Williams, J., Guy, A., Omodei, G., Johnson, B., Williams, H., O'Neill, S. L., Ritchie, S. A., Dobson, S. L. & Madan, D., Dec 2017, In : PLoS Neglected Tropical Diseases. 11, 12, p. e0006142 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Comparison of stable and transient Wolbachia infection models in Aedes aegypti to block dengue and West Nile viruses

Joubert, D. A. & O’Neill, S. L., 4 Jan 2017, In : PLoS Neglected Tropical Diseases. 11, 1, 14 p., e0005275.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Field- and clinically derived estimates of Wolbachia-mediated blocking of dengue virus transmission potential in Aedes aegypti mosquitoes

Carrington, L. B., Tran, B. C. N., Le, N. T. H., Luong, T. T. H., Nguyen, T. T., Nguyen, P. T., Chau, N. V. V., Nguyen, H. T. C., Vu, T. T., Vo, L. T., Le, D. T., Vu, N. T., Nguyen, G. T., Luu, H. Q., Dang, A. D., Hurst, T. P., O’Neill, S. L., Tran, V. T., Kien, D. T. H., Nguyen, N. M. & 3 others, Wolbers, M., Wills, B. & Simmons, C. P., 9 Jan 2017, In : Proceedings of the National Academy of Sciences of the United States of America. 115, 2, p. 361-366 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Local introduction and heterogeneous spatial spread of dengue-suppressing Wolbachia through an urban population of Aedes aegypti

Schmidt, T. L., Barton, N. H., Rašić, G., Turley, A. P., Montgomery, B. L., Iturbe-Ormaetxe, I., Cook, P. E., Ryan, P. A., Ritchie, S. A., Hoffmann, A. A., O’Neill, S. L. & Turelli, M., 30 May 2017, In : PLoS Biology. 15, 5, 28 p., e2001894.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Novel Wolbachia-transinfected Aedes aegypti mosquitoes possess diverse fitness and vector competence phenotypes

Fraser, J. E., De Bruyne, J. T., Iturbe-Ormaetxe, I., Stepnell, J., Burns, R. L., Flores, H. A. & O’Neill, S. L., 1 Dec 2017, In : PLoS Pathogens. 13, 12, 19 p., e1006751.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Screening of Wolbachia Endosymbiont Infection in Aedes aegypti Mosquitoes Using Attenuated Total Reflection Mid-Infrared Spectroscopy

Khoshmanesh, A., Christensen, D., Perez-Guaita, D., Iturbe-Ormaetxe, I., O'Neill, S. L., McNaughton, D. & Wood, B. R., 16 May 2017, In : Analytical Chemistry. 89, 10, p. 5285-5293 9 p.

Research output: Contribution to journalArticleResearchpeer-review

The elimination of the dengue vector, Aedes aegypti, from Brisbane, Australia: The role of surveillance, larval habitat removal and policy

Trewin, B. J., Darbro, J. M., Jansen, C. C., Schellhorn, N. A., Zalucki, M. P., Hurst, T. P. & Devine, G. J., 1 Aug 2017, In : PLoS Neglected Tropical Diseases. 11, 8, 23 p., e0005848.

Research output: Contribution to journalArticleResearchpeer-review

The RNAi pathway plays a small part in Wolbachia-mediated blocking of dengue virus in mosquito cells

Terradas, G., Joubert, D. A. & McGraw, E. A., 6 Mar 2017, In : Scientific Reports. 7, 13 p., 43847.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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2016

A native Wolbachia endosymbiont does not limit dengue virus infection in the mosquito Aedes notoscriptus (Diptera: Culicidae)

Skelton, E., Rancès, E., Frentiu, F. D., Kusmintarsih, E. S., Iturbe-Ormaetxe, I., Caragata, E. P., Woolfit, M. & O'Neill, S. L., 1 Mar 2016, In : Journal of Medical Entomology. 53, 2, p. 401-408 8 p.

Research output: Contribution to journalArticleResearchpeer-review

2015

The dengue stopper

O'Neill, S., Jun 2015, In : Scientific American. 312, 6, p. 72-77 6 p.

Research output: Contribution to journalArticleOther

2010

The burden and characteristics of enteric fever at a healthcare facility in a densely populated area of kathmandu

Karkey, A., Arjyal, A., Anders, K. L., Boni, M. F., Dongol, S., Koirala, S., My, P. V. T., Nga, T. V. T., Clements, A. C. A., Holt, K. E., Duy, P. T., Day, J. N., Campbel, J. I., Dougan, G., Dolecek, C., Farrar, J., Basnyat, B. & Baker, S., 9 Dec 2010, In : PLoS ONE. 5, 11, e13988.

Research output: Contribution to journalArticleResearchpeer-review

2008

Decision tree algorithms predict the diagnosis and outcome of dengue fever in the early phase of illness

Tanner, L., Schreiber, M., Low, J. G. H., Ong, A., Tolfvenstam, T., Lai, Y. L., Ng, L. C., Leo, Y. S., Puong, L. T., Vasudevan, S. G., Simmons, C. P., Hibberd, M. L. & Ooi, E. E., 1 Mar 2008, In : PLoS Neglected Tropical Diseases. 2, 3, e196.

Research output: Contribution to journalArticleResearchpeer-review

Dengue in Vietnamese infants - Results of infection-enhancement assays correlate with age-related disease epidemiology, and cellular immune responses correlate with disease severity

Chau, T. N. B., Quyen, N. T. H., Tran, T. T., Nguyen, M. T., Dang, M. H., Dung, N. T. P., Le, B. L., Nguyen, T. Q., Nguyen, T. H., Hieu, L. T. M., Tran, T. H., Nguyen, T. H., Farrar, J. & Simmons, C. P., 15 Aug 2008, In : Journal of Infectious Diseases. 198, 4, p. 516-524 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Identification of tuberculosis susceptibility genes with human macrophage gene expression profiles

Thuong, N. T. T., Dunstan, S. J., Chau, T. T. H., Thorsson, V., Simmons, C. P., Quyen, N. T. H., Thwaites, G. E., Lan, N. T. N., Hibberd, M., Teo, Y. Y., Seielstad, M., Aderem, A., Farrar, J. J. & Hawn, T. R., 1 Dec 2008, In : PLoS Pathogens. 4, 12, e1000229.

Research output: Contribution to journalArticleResearchpeer-review

Memory T cells established by seasonal human influenza A infection cross-react with avian influenza A (H5N1) in healthy individuals

Lee, L. Y. H., Ha, D. L. A., Simmons, C., De Jong, M. D., Chau, N. V. V., Schumacher, R., Yan, C. P., McMichael, A. J., Farrar, J. J., Smith, G. L., Townsend, A. R. M., Askonas, B. A., Rowland-Jones, S. & Dong, T., 1 Oct 2008, In : Journal of Clinical Investigation. 118, 10, p. 3478-3490 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Preservation of a critical epitope core region is associated with the high degree of flaviviral cross-reactivity exhibited by a dengue-specific CD4+ T cell clone

Moran, E., Simmons, C., Chau, N. V., Luhn, K., Wills, B., Dung, N. P., Thao, L. T. T., Hien, T. T., Wills, B., Dung, N. P., Thao, L. T. T., Hien, T. T., Farrar, J., Rowland-Jones, S. & Dong, T., 1 Apr 2008, In : European Journal of Immunology. 38, 4, p. 1050-1057 8 p.

Research output: Contribution to journalArticleResearchpeer-review

2007

High pro-inflammatory cytokine secretion and loss of high avidity cross-reactive cytotoxic T-cells during the course of secondary dengue virus infection

Dong, T., Moran, E., Vinh Chau, N. V., Simmons, C., Luhn, K., Peng, Y., Wills, B., Phuong Dung, N., Thi Thu Thao, L., Hien, T. T., McMichael, A., Farrar, J. & Rowland-Jones, S., 5 Dec 2007, In : PLoS ONE. 2, 12, e1192.

Research output: Contribution to journalArticleResearchpeer-review

Increased frequencies of CD4+CD25high regulatory T cells in acute dengue infection

Lühn, K., Simmons, C. P., Moran, E., Dung, N. T. P., Chau, T. N. B., Quyen, N. T. H., Thao, L. T. T., Van Ngoc, T., Nguyen, M. D., Wills, B., Farrar, J., McMichael, A. J., Dong, T. & Rowland-Jones, S., 1 May 2007, In : Journal of Experimental Medicine. 204, 5, p. 979-985 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Maternal antibody and viral factors in the pathogenesis of dengue virus in infants

Simmons, C. P., Chau, T. N. B., Tran, T. T., Nguyen, M. T., Dang, M. H., Nguyen, T. T., Le, B. L., Nguyen, T. Q., Nguyen, T. H., Tran, T. H., McElnea, C., Young, P., Whitehead, S., Nguyen, T. H. & Farrar, J., 1 Aug 2007, In : Journal of Infectious Diseases. 196, 3, p. 416-424 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Patterns of host genome-wide gene transcript abundance in the peripheral blood of patients with acute dengue hemorrhagic fever

Simmons, C. P., Popper, S., Dolocek, C., Chan, T. N. B., Griffiths, M., Dung, N. T. P., Long, T. H., Hoang, D. M., Chau, N. V., Thao, L. T. T., Hien, T. T., Relman, D. A. & Farrar, J., 15 Apr 2007, In : Journal of Infectious Diseases. 195, 8, p. 1097-1107 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Prophylactic and therapeutic efficacy of human monoclonal antibodies against H5N1 influenza

Simmons, C. P., Bernasconi, N. L., Suguitan, A. L., Mills, K., Ward, J. M., Chau, N. V. V., Tran, T. H., Sallusto, F., Do, Q. H., Farrar, J., De Jong, M. D., Lanzavecchia, A. & Subbarao, K., 1 May 2007, In : PLoS Medicine. 4, 5, p. 928-936 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Serial MRI to determine the effect of dexamethasone on the cerebral pathology of tuberculous meningitis: an observational study

Thwaites, G. E., Macmullen-Price, J., Chau, T. T. H., Phuong Mai, P., Dung, N. T., Simmons, C. P., White, N. J., Hien, T. T., Summers, D. & Farrar, J. J., 1 Mar 2007, In : The Lancet Neurology. 6, 3, p. 230-236 7 p.

Research output: Contribution to journalArticleResearchpeer-review

2006

Fatal outcome of human influenza A (H5N1) is associated with high viral load and hypercytokinemia

De Jong, M. D., Simmons, C. P., Thanh, T. T., Hien, V. M., Smith, G. J. D., Chau, T. N. B., Hoang, D. M., Chau, N. V. V., Khanh, T. H., Dong, V. C., Qui, P. T., Cam, B. V., Ha, D. Q., Guan, Y., Peiris, J. S. M., Chinh, N. T., Hien, T. T. & Farrar, J., 1 Oct 2006, In : Nature Medicine. 12, 10, p. 1203-1207 5 p.

Research output: Contribution to journalArticleResearchpeer-review

Pretreatment intracerebral and peripheral blood immune responses in vietnamese adults with tuberculous meningitis: Diagnostic value and relationship to disease severity and outcome

Simmons, C. P., Thwaites, G. E., Quyen, N. T. H., Torok, E., Hoang, D. M., Chau, T. T. H., Mai, P. P., Lan, N. T. N., Dung, N. H., Quy, H. T., Bang, N. D., Hien, T. T. & Farrar, J., 1 Feb 2006, In : Journal of Immunology. 176, 3, p. 2007-2014 8 p.

Research output: Contribution to journalArticleResearchpeer-review

2005

Early T-cell responses to dengue virus epitopes in Vietnamese adults with secondary dengue virus infections

Simmons, C. P., Dong, T., Chau, N. V., Dung, N. T. P., Chau, T. N. B., Thao, L. T. T., Dung, N. T., Hien, T. T., Rowland-Jones, S. & Farrar, J., 1 May 2005, In : Journal of Virology. 79, 9, p. 5665-5675 11 p.

Research output: Contribution to journalArticleResearchpeer-review

The clinical benefit of adjunctive dexamethasone in tuberculous meningitis is not associated with measurable attenuation of peripheral or local immune responses

Simmons, C. P., Thwaites, G. E., Quyen, N. T. H., Chau, T. T. H., Mai, P. P., Dung, N. T., Stepniewska, K., White, N. J., Hien, T. T. & Farrar, J., 1 Jul 2005, In : Journal of Immunology. 175, 1, p. 579-590 12 p.

Research output: Contribution to journalArticleResearchpeer-review

The influence of HIV infection on clinical presentation, response to treatment and outcome in adults with tuberculous meningitis

Thwaites, G. E., Bang, N. D., Dung, N. H., Quy, H. T., Oanh, D. T. T., Thoa, N. T. C., Hien, N. Q., Thuc, N. T., Hai, N. N., Lan, N. T. N., Lan, N. N., Duc, N. H., Tuan, V. N., Hiep, C. H., Chau, T. T. H., Mai, P. P., Dung, N. T., Stepniewska, K., Simmons, C. P., White, N. J. & 2 others, Hien, T. T. & Farrar, J. J., 15 Dec 2005, In : Journal of Infectious Diseases. 192, 12, p. 2134-2141 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Vaccine-induced protection against gastrointestinal bacterial infections in the absence of secretory antibodies

Uren, T. K., Wijburg, O. L. C., Simmons, C., Johansen, F. E., Brandtzaeg, P. & Strugnell, R. A., 1 Jan 2005, In : European Journal of Immunology. 35, 1, p. 180-188 9 p.

Research output: Contribution to journalArticleResearchpeer-review

2003

Pathophysiology and Prognosis in Vietnamese Adults with Tuberculous Meningitis

Thwaites, G. E., Simmons, C. P., Quyen, N. T. H., Chau, T. T. H., Mai, P. P., Dung, N. T., Phu, N. H., White, N. P., Hien, T. T. & Farrar, J. J., 15 Oct 2003, In : Journal of Infectious Diseases. 188, 8, p. 1105-1115 11 p.

Research output: Contribution to journalArticleResearchpeer-review

2000

Dual role for macrophages in vivo in pathogenesis and control of murine Salmonella enterica var. Typhimurium infections

Wijburg, O. L. C., Simmons, C. P., Van Rooijen, N. & Strugnell, R. A., 3 May 2000, In : European Journal of Immunology. 30, 3, p. 944-953 10 p.

Research output: Contribution to journalArticleResearchpeer-review

1999

Use of in vivo-regulated promoters to deliver antigens from attenuated Salmonella enterica var. typhimurium

Dunstan, S. J., Simmons, C. P. & Strugnell, R. A., 7 Oct 1999, In : Infection and Immunity. 67, 10, p. 5133-5141 9 p.

Research output: Contribution to journalArticleResearchpeer-review

1998

Comparison of the abilities of different attenuated Salmonella typhimurium strains to elicit humoral immune responses against a heterologous antigen

Dunstan, S. J., Simmons, C. P. & Strugnell, R. A., 1 Jan 1998, In : Infection and Immunity. 66, 2, p. 732-740 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Studies of the pathogenesis and immunology of attenuated mutants of Salmonella enterica var. Typhimurium: Lessons for human typhoid fever?

Dunstan, S. J., Simmons, C. P., Wijburg, O. L. C., Uren, T. K., van Rooijen, N. & Strugnell, R. A., 1 Jan 1998, In : Medical Journal of Indonesia. 7, p. 74-80 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Vaccine potential of attenuated mutants of Corynebacterium pseudotuberculosis in sheep

Simmons, C. P., Dunstan, S. J., Jachedjian, M., Krywult, J., Hodgson, A. L. M. & Strugnell, R. A., 25 Feb 1998, In : Infection and Immunity. 66, 2, p. 474-479 6 p.

Research output: Contribution to journalArticleResearchpeer-review

1997

Attenuation and vaccine potential of aroQ mutants of Corynebacterium pseudotuberculosis

Simmons, C. P., Hodgson, A. L. M. & Strugnell, R. A., 26 Aug 1997, In : Infection and Immunity. 65, 8, p. 3048-3056 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Identification and characterization of a K88- and CS31A-like operon of a rabbit enteropathogenic Escherichia coli strain which encodes fimbriae involved in the colonization of rabbit intestine

Adams, L. M., Simmons, C. P., Rezmann, L., Strugnell, R. A. & Robins-Browne, R. M., 12 Dec 1997, In : Infection and Immunity. 65, 12, p. 5222-5230 9 p.

Research output: Contribution to journalArticleResearchpeer-review