Research Output 1983 2019

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2012
92 Citations (Scopus)

HDAC inhibitors in HIV

Wightman, F., Ellenberg, P. C., Churchill, M. & Lewin, S. R., 2012, In : Immunology and Cell Biology. 90, 1, p. 47 - 54 8 p.

Research output: Contribution to journalArticleResearchpeer-review

45 Citations (Scopus)

HIV-Associated Sensory Neuropathy: Risk Factors and Genetics

Kamerman, P. R., Wadley, A. L. & Cherry, C., 2012, In : Current Pain and Headache Reports. 16, 3, p. 226 - 236 11 p.

Research output: Contribution to journalArticleOther

9 Citations (Scopus)

HIV-associated sensory neuropathy: still a problem in the post-stavudine era?

Cherry, C., Kamerman, P., Bennett, D. LH. & Rice, A. SC., 2012, In : Future Virology. 7, 9, p. 849 - 854 6 p.

Research output: Contribution to journalArticleResearchpeer-review

7 Citations (Scopus)

HIV Infection and TLR signalling in the liver

Crane, M., Visvanathan, K. & Lewin, S. R., 2012, In : Gastroenterology Research and Practice. 2012, p. e473925 - e473925 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
7 Citations (Scopus)

HIV persistence: chemokines and their signalling pathways

Evans, V. A., Khoury, G., Saleh, S. M., Cameron, P. U. & Lewin, S. R., 2012, In : Cytokine and Growth Factor Reviews. 23, 4-5, p. 151 - 157 7 p.

Research output: Contribution to journalArticleResearchpeer-review

12 Citations (Scopus)

HIV replication is associated with increased severity of liver biopsy changes in HIV-HBV and HIV-HCV co-infection

Audsley, J. M., Du Cros, P. A., Goodman, Z., McLean, C. A., Mijch, A. M., Lewin, S. R. & Sasadeusz, J., 2012, In : Journal of Medical Virology. 84, 7, p. 993 - 1001 9 p.

Research output: Contribution to journalArticleResearchpeer-review

30 Citations (Scopus)

HIV taken by STORM: Super-resolution fluorescence microscopy of a viral infection

Pereira, C. D. F., Rossy, J., Owen, D. M., Mak, J. & Gaus, K., 2012, In : Virology Journal. 9, Art. No.: 84, p. 1 - 6 6 p.

Research output: Contribution to journalArticleResearchpeer-review

27 Citations (Scopus)

Human immunodeficiency virus infection and the liver

Crane, M., Iser, D. & Lewin, S. R., 27 Mar 2012, In : World Journal of Hepatology. 4, 3, p. 91-98 8 p.

Research output: Contribution to journalArticleResearchpeer-review

6 Citations (Scopus)

In vitro replication phenotype of a novel (-1G) hepatitis B virus variant associated with HIV co-infection

Cabuang, L. M., Shaw, T., Littlejohn, M., Colledge, D., Sozzi, V., Soppe, S., Warner, N., Thompson, A. J. V., Preiss, S., Lam, N., Walsh, R. B., Lewin, S. R., Thio, C. L., Matthews, G., Locarnini, S. & Revill, P., 2012, In : Journal of Medical Virology. 84, 8, p. 1166 - 1176 11 p.

Research output: Contribution to journalArticleResearchpeer-review

4 Citations (Scopus)

New HIV diagnosis after occupational exposure screening: The importance of reporting needlestick injuries

Upjohn, L. M., Stuart, R., Korman, T. & Woolley, I. J., 2012, In : Internal Medicine Journal. 42, 2, p. 202 - 204 3 p.

Research output: Contribution to journalArticleOther

Shooting at the DARC: potential issues with species-specific antimalarials

Woolley, I. J. & Horne, K., 2012, In : Infectious Disorders - Drug Targets. 12, 5, p. 357 - 359 3 p.

Research output: Contribution to journalArticleOtherpeer-review

5 Citations (Scopus)

Successful use of eltrombopag without splenectomy in refractory HIV-related immune reconstitution thrombocytopenia

Quach, H., Lee, L. Y. L., Smith, B., Korman, T. & Woolley, I. J., 2012, In : AIDS. 26, 15, p. 1977 - 1979 3 p.

Research output: Contribution to journalArticleOther

31 Citations (Scopus)

The multidrug-resistant PMEN1 pneumococcus is a paradigm for genetic success

Wyres, K. L., Lambertsen, L. M., Croucher, N. J., McGee, L., von Gottberg, A., Liñares, J., Jacobs, M. R., Kristinsson, K. G., Beall, B. W., Klugman, K. P., Parkhill, J., Hakenbeck, R., Bentley, S. D. & Brueggemann, A. B., 16 Nov 2012, In : Genome Biology. 13, 11, R103.

Research output: Contribution to journalArticleResearchpeer-review

20 Citations (Scopus)

The role of SNPs in the a-chain of the IL-7R gene in CD4 T-cell recovery in HIV-infected African patients receiving suppressive cART

Rajasuriar, R., Booth, D. R., Gouillou, M., Spelman, T. D., James, I. R., Solomon, A., Chua, K., Stewart, G., Deeks, S. G., Bangsberg, D. R., Muzoora, C., Cameron, P., Hunt, P., Martin, J. & Lewin, S., 2012, In : Genes and Immunity. 13, p. 83 - 93 11 p.

Research output: Contribution to journalArticleResearchpeer-review

355 Citations (Scopus)

Towards an HIV cure: a global scientific strategy

Deeks, S. G., Autran, B., Berkhout, B., Benkirane, M., Cairns, S., Chomont, N., Chun, T. W., Churchill, M., Di Mascio, M., Katlama, C., Lafeuillade, A., Landay, A., Lederman, M. M., Lewin, S. R., Maldarelli, F., Margolis, D. M., Markowitz, M. M., Martinez-Picado, J., Mullins, J., Mellors, J. W. & 16 others, Moreno, S., O'Doherty, U. M., Palmer, S., Penicaud, M. C., Peterlin, M. B., Poli, G., Routy, J. P., Rouzioux, C., Silvestri, G., Stevenson, M., Telenti, A., Van Lint, C., Verdin, E., Woolfrey, A., Zaia, J. A. & Barre-Sinoussi, F., 2012, In : Nature Reviews Immunology. 12, 8, p. 607 - 614 8 p.

Research output: Contribution to journalArticleResearchpeer-review

109 Citations (Scopus)

Tuberculosis diagnostics and biomarkers: needs, challenges, recent advances, and opportunities

McNerney, R., Maeurer, M., Abubakar, I., Marais, B., Mchugh, T., Ford, N., Weyer, K., Lawn, S., Grobusch, M., Memish, Z. A., Squire, S. B., Pantaleo, G., Chakaya, J., Casenghi, M., Migliori, G-B., Mwaba, P., Zijenah, L., Hoelscher, M., Cox, H., Swaminathan, S. & 10 others, Kim, P. S., Schito, M., Harari, A., Bates, M., Schwank, S., O'Grady, J., Pletschette, M., Ditui, L., Atun, R. & Zumla, A., 2012, In : Journal of Infectious Diseases. 205, Suppl 2, p. S147 - S158 12 p.

Research output: Contribution to journalArticleResearchpeer-review

5 Citations (Scopus)

Utility of RhoC and ZAG protein expression as biomarkers for prediction of PSA failure following radical prostatectomy for high grade prostate cancer

Mills, J., Oliver, A., Sherwin, J., Frydenberg, M., Peters, J. S., Costello, A., Harewood, L., Love, C., Redgrave, N., van Golen, K. L., Bailey, M. J. & Pedersen, J. S., 2012, In : Pathology. 44, 6, p. 513 - 518 6 p.

Research output: Contribution to journalArticleResearchpeer-review

8 Citations (Scopus)

Visiting friends and relatives may be a risk for non-adherence for HIV-positive travellers

Woolley, I. & Bailey, C., 2012, In : International Journal of STD and AIDS. 23, 11, p. 833-834 2 p.

Research output: Contribution to journalArticleOtherpeer-review

2011
4 Citations (Scopus)
19 Citations (Scopus)

An Australian survey of clinical practices in management of neutropenic fever in adult cancer patients 2009

Lingaratnam, S., Slavin, M. A., Mileshkin, L., Solomon, B., Burbury, K., Seymour, J. F., Sharma, R., Koczwara, B., Kirsa, S. W., Davis, I. D., Prince, M., Szer, J., Underhill, C., Morrissey, O. & Thursky, K. A., Jan 2011, In : Internal Medicine Journal. 41, p. 110-120 11 p.

Research output: Contribution to journalArticleResearchpeer-review

14 Citations (Scopus)

A new preoperative nomogram to predict minimal prostate cancer: Accuracy and error rates compared to other tools to select patients for active surveillance

O'Brien, B. A., Cohen, R. J., Ryan, A., Sengupta, S. & Mills, J., Nov 2011, In : Journal of Urology. 186, 5, p. 1811-1817 7 p.

Research output: Contribution to journalArticleResearchpeer-review

18 Citations (Scopus)

Balamuthia mandrillaris brain abscess successfully treated with complete surgical excision and prolonged combination antimicrobial therapy: Case report

Doyle, J. S., Campbell, E., Fuller, A., Spelman, D. W., Cameron, R., Malham, G., Gin, D. & Lewin, S. R., 2011, In : Journal of Neurosurgery. 114, 2, p. 458-462 5 p.

Research output: Contribution to journalArticleOtherpeer-review

21 Citations (Scopus)

CD4-binding site alterations in CCR5-using HIV-1 envelopes influencing gp120-CD4 interactions and fusogenicity

Sterjovski, J., Churchill, M. J., Roche, M., Ellett, A., Farrugia, W., Wesselingh, S. L., Cunningham, A. L., Ramsland, P. A. & Gorry, P. R., 20 Feb 2011, In : Virology. 410, 2, p. 418-428 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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45 Citations (Scopus)

HIV neuropathy risk factors and symptom characterization in stavudine-exposed South Africans

Wadley, A. L., Cherry, C. L., Price, P. & Kamerman, P. R., Apr 2011, In : Journal of Pain and Symptom Management. 41, 4, p. 700-706 7 p.

Research output: Contribution to journalArticleResearchpeer-review

5 Citations (Scopus)

Improved detection of mycobacteria species in formalin-fixed tissue sections

Pedersen, J. S., Clarke, I. & Mills, J., Nov 2011, In : Histopathology. 59, 5, p. 993-1005 13 p.

Research output: Contribution to journalArticleResearchpeer-review

17 Citations (Scopus)

Introduction to the Australian consensus guidelines for the management of neutropenic fever in adult cancer patients, 2010/2011

Lingaratnam, S., Slavin, M., Koczwara, B., Seymour, J. F., Szer, J., Underhill, C., Prince, M., Mileshkin, L., O'Reilly, M., Kirsa, S. W., Bennett, C. A., Davis, I., Morrissey, O. & Thursky, K. A., 2011, In : Internal Medicine Journal. 41, p. 75 - 81 7 p.

Research output: Contribution to journalArticleResearchpeer-review

20 Citations (Scopus)

Neurobehavioral effects in HIV-Positive individuals receiving highly active antiretroviral therapy (HAART) in Gaborone, Botswana

Lawler, K., Jeremiah, K., Mosepele, M., Ratcliffe, S. J., Cherry, C., Seloilwe, E. & Steenhoff, A. P., 18 Feb 2011, In : PLoS ONE. 6, 2, 7 p., e17233.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
8 Citations (Scopus)

Plasmodium species co-infection as a cause of treatment failure

Smith, A., Denholm, J. T., Shortt, J. & Spelman, D. W., 2011, In : Travel Medicine and Infectious Disease. 9, 6, p. 306 - 309 4 p.

Research output: Contribution to journalArticleResearchpeer-review

2010

Australasian HIV/AIDS conference 2009

Wright, E. J., Cameron, P., Reis, E. & Lewine, S. R., Jan 2010, In : HIV Therapy. 4, 1, p. 9-11 3 p.

Research output: Contribution to journalArticleResearchpeer-review

12 Citations (Scopus)

Effects of intermittent IL-2 alone or with peri-cycle antiretroviral therapy in early HIV infection: The STALWART study

Tavel, J. A., Babiker, A., Carey, C., Fisher, M., Fox, L., Gey, D., Lopardo, G. D., Lopez, J. C., Markowitz, N., Munroe, D., Paton, N., Ruxrungtham, K., Standridge, B., Wentworth, D., Wyman, N., Aagaard, B., Borup, L., Grarup, J., Jansson, P. O., Jensen, K. & 94 others, Lundgren, J., Mollerup, D., Reilev, S., Braimah, N., Darbyshire, J., Horton, J., King, E., Smith, N., Van Hooff, F., Cooper, D. A., Courtney-Rodgers, D., Emery, S., Finley, E., Gordin, F., Sánchez, A., Thomas, D., Bebchuk, J., Bollenbeck, P., Denning, E., DuChene, A. G., Fosdick, L., Harrison, M., Krum, E., Larson, G., Neaton, J. D., Nelson, R., Quan, K., Quan, S. F. L., Schultz, T., Thompson, G., Collins, S., Haerry, D. H., Meulbroek, M., Peavy, D., Rappoport, C., Schwarze, S., Valdez, M., Watson, J., Belloso, W. H., Davey, R., Duprez, D., Gatell, J. M., Hoy, J., Lifson, A., Pederson, C., Perez, G., Price, R., Prineas, R., Rhame, F., Sampson, J. H., Worley, J., Modlin, J. F., Beral, V., Chaisson, R. E., Fleming, T. R., Hill, C., Kim, K. M., Murray, B. E., Pick, B., Seligmann, M., Weller, I., Luzar, M. A., Martinez, A., Costas, V., Eckstrand, J., Brown, S., Lupo, S. H., Losso, M. H., Anderson, J., Chuah, J., Kelly, M., Orth, D., Wolff, M. J., Rusconi, S., Tambussi, G., Horban, A., Antunes, F., Mansinho, K., Da Conceicao Vera, J. A. V., Himmich, H., Chetchotisakd, P., Kantipong, P., Orkin, C., Portsmouth, S., Winston, A., Wiselka, M. J., Anstead, G. M., Arduino, R. C., Goetz, M. B., Hennessey, K., El-Sadr, W., Labriola, A. M., Nixon, D. E. & Rodriguez-Barradas, M. C., 23 Feb 2010, In : PLoS ONE. 5, 2, e9334.

Research output: Contribution to journalArticleResearchpeer-review

49 Citations (Scopus)

Environmental factors determining the epidemiology and population genetic structure of the bacillus cereus group in the field

Raymond, B., Wyres, K. L., Sheppard, S. K., Ellis, R. J. & Bonsall, M. B., 1 May 2010, In : PLoS Pathogens. 6, 5, p. 1-13 13 p.

Research output: Contribution to journalArticleResearchpeer-review

2 Citations (Scopus)

Extremely prolonged HIV seroconversion associated with an MHC haplotype carrying disease susceptibility genes for antibody deficiency disorders

Padiglione, A., Aleksic, E., French, M., Arnott, A., Wilson, K. M., Tippett, E., Kaye, M., Gray, L., Ellett, A., Crane, M., Leslie, D. E., Lewin, S. R., Breschkin, A., Birch, C., Gorry, P. R., McPhee, D. A. & Crowe, S. M., Nov 2010, In : Clinical Immunology. 137, 2, p. 199-208 10 p.

Research output: Contribution to journalArticleResearchpeer-review

48 Citations (Scopus)

Quantifying HIV for monitoring antiretroviral therapy in resource-poor settings.

Stevens, W. S., Scott, L. E. & Crowe, S. M., 15 Apr 2010, In : Journal of Infectious Diseases. 201 Suppl 1

Research output: Contribution to journalArticleResearchpeer-review

7 Citations (Scopus)

Spleen registry may help reduce the incidence of overwhelming postsplenectomy infection in Victoria

Denholm, J. T., Jones, P. A., Spelman, D. W., Cameron, P. U. & Woolley, I. J., 4 Jan 2010, In : Medical Journal of Australia. 192, 1, p. 49-50 2 p.

Research output: Contribution to journalArticleResearchpeer-review

8 Citations (Scopus)

The role of general quality improvement measures in decreasing the burden of endemic MRSA in a medical-surgical intensive care unit

Ananda-Rajah, M. R., Mcbryde, E. S., Buising, K. L., Redl, L., Macisaac, C., Cade, J. F. & Marshall, C., Nov 2010, In : Intensive Care Medicine. 36, 11, p. 1890-1898 9 p.

Research output: Contribution to journalArticleResearchpeer-review

2009
178 Citations (Scopus)

A genome-wide association study identifies novel and functionally related susceptibility loci for Kawasaki disease

Burgner, D., Davila, S., Breunis, W. B., Ng, S. B., Li, Y., Bonnard, C., Ling, L., Wright, V. J., Thalamuthu, A., Odam, M., Shimizu, C., Burns, J. C., Levin, M. E., Kuijpers, T. W., Hibberd, M. L., Christiansen, F., Witt, C. S., Goldwater, P., Curtis, N., Palasanthiran, P. & 26 others, Ziegler, J., Nissan, M., Nourse, C., Kuipers, I. M., Ottenkamp, J. J., Geissler, J., Biezeveld, M., Filippini, L., Brogan, P., Klein, N., Shah, V., Dillon, M., Booy, R., Shingadia, D., Bose, A., Mukasa, T., Tulloh, R., Michie, C., Shike, H., Nievergelt, C. M., Schork, N. J., Newburger, J. W., Baker, A. L., Sundel, R. P., Rowley, A. H. & Shulman, S. T., Jan 2009, In : PLoS Genetics. 5, 1, e1000319.

Research output: Contribution to journalArticleResearchpeer-review

26 Citations (Scopus)

A randomized, placebo-controlled, dose-escalation study to determine the safety, tolerability, and immunogenicity of an HPV-16 therapeutic vbaccine in HIV-positive participants with oncogenic HPV infection of the anus

Anderson, J. S., Hoy, J., Hillman, R., Barnden, M., Eu, B., McKenzie, A. & Gittleson, C., 1 Nov 2009, In : Journal of Acquired Immune Deficiency Syndromes. 52, 3, p. 371-381 11 p.

Research output: Contribution to journalArticleResearchpeer-review

62 Citations (Scopus)

Efficacy and safety of darunavir/ritonavir in treatment-experienced HIV type-1 patients in the POWER 1, 2 and 3 trials at week 96

Arastéh, K., Yeni, P., Pozniak, A., Grinsztejn, B., Jayaweera, D., Roberts, A., Hoy, J., De Meyer, S., Vangeneugden, T. & Tomaka, F., 21 Dec 2009, In : Antiviral Therapy. 14, 6, p. 859-864 6 p.

Research output: Contribution to journalArticleResearchpeer-review

73 Citations (Scopus)

Population-based surveillance for scedosporiosis in Australia: Epidemiology, disease manifestations and emergence of Scedosporium aurantiacum infection

Heath, C. H., Slavin, M. A., Sorrell, T. C., Handke, R., Harun, A., Phillips, M., Nguyen, Q., Delhaes, L., Ellis, D., Meyer, W., Chen, S. C. A. & on behalf of the Australian Scedosporium Study Group, 1 Jan 2009, In : Clinical Microbiology and Infection. 15, 7, p. 689-693 5 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

The spectrum of retinopathy in adults with P. falciparum malaria

Maude, RJ., Beare, NAV., Sayeed, AA., Chang, C. C., Hanson, J., Charunwatthana, P., Faiz, MA., Hossain, A., Yunus, EB., Hoque, MG., Hasan, MU., White, NJ., Day, NPJ. & Dondorp, AJ., 2009, In : Transactions of the Royal Society of Tropical Medicine and Hygiene. 103, 7, p. 665-71

Research output: Contribution to journalArticleResearchpeer-review

2008
14 Citations (Scopus)

Abnormal anal cytology in high-risk human papilloma virus infection in HIV-infected Australians

Anderson, J. S., Hoy, J., Hillman, R., Gittleson, C., Hartel, G., Medley, G. & Basser, R., 1 Apr 2008, In : Sexually Transmitted Infections. 84, 2, p. 94-96 3 p.

Research output: Contribution to journalArticleResearchpeer-review

25 Citations (Scopus)

Effect of rosiglitazone on peroxisome proliferator-activated receptor γ gene expression in human adipose tissue is limited by antiretroviral drug - Induced mitochondrial dysfunction

Mallon, P. W. G., Sedwell, R., Rogers, G., Nolan, D., Unemori, P., Hoy, J., Samaras, K., Kelleher, A., Emery, S., Cooper, D. A. & Carr, A., 15 Dec 2008, In : Journal of Infectious Diseases. 198, 12, p. 1794-1803 10 p.

Research output: Contribution to journalArticleResearchpeer-review

157 Citations (Scopus)

Inferior clinical outcome of the CD4+ cell count-guided antiretroviral treatment interruption strategy in the SMART study: Role of CD4+ cell counts and HIV RNA levels during follow-up

The Strategies for Management of Antiretroviral Therapy (SMART) Study Group, 15 Apr 2008, In : Journal of Infectious Diseases. 197, 8, p. 1145-1155 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
306 Citations (Scopus)

Major clinical outcomes in antiretroviral therapy (ART)-naive participants and in those not receiving ART at baseline in the SMART Study

The Strategies for Management of Antiretroviral Therapy (SMART) Study Group, 15 Apr 2008, In : Journal of Infectious Diseases. 197, 8, p. 1133-1144 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
57 Citations (Scopus)

Neurologic disorders are prevalent in HIV-positive outpatients in the Asia-Pacific region

Wright, E., Brew, B., Arayawichanont, A., Robertson, K., Samintharapanya, K., Kongsaengdao, S., Lim, M., Vonthanak, S., Lal, L., Sarim, C., Huffam, S., Li, P., Imran, D., Lewis, J., Lun, W. H., Kamarulzaman, A., Tau, G., Ali, S. T., Kishore, K., Bain, M. P. & 6 others, Dwyer, R., McCormack, G., Hellard, M., Cherry, C., McArthur, J. & Wesselingh, S. L., 2008, In : Neurology. 71, 1, p. 50 - 56 7 p.

Research output: Contribution to journalArticleResearchpeer-review

114 Citations (Scopus)

Risk for opportunistic disease and death after reinitiating continuous antiretroviral therapy in patients with HIV previously receiving episodic therapy: A randomized trial

The SMART Study Group, 2 Sep 2008, In : Annals of Internal Medicine. 149, 5, p. 289-299 11 p.

Research output: Contribution to journalArticleResearchpeer-review

146 Citations (Scopus)

The etiology of community-acquired pneumonia in Australia: Why penicillin plus doxycycline or a macrolide is the most appropriate therapy

Charles, P. G. P., Whitby, M., Fuller, A. J., Stirling, R., Wright, A. A., Korman, T. M., Holmes, P. W., Christiansen, K. J., Waterer, G. W., Pierce, R. J. P., Mayall, B. C., Armstrong, J. G., Catton, M. G., Nimmo, G. R., Johnson, B., Hooy, M., Grayson, M. L. & Australian CAP Study Collaboration, 15 May 2008, In : Clinical Infectious Diseases. 46, 10, p. 1513-1521 9 p.

Research output: Contribution to journalArticleResearchpeer-review

9 Citations (Scopus)

Torsades de pointes in a patient receiving fluconazole for cerebral cryptococcosis

McMahon, J. H. & Grayson, M. L., 2008, In : Am J Health Syst Pharm. 65, 7, p. 619-623 5 p.

Research output: Contribution to journalArticleResearchpeer-review

2007

4th International AIDS Society Conference on HIV pathogenesis, treatment and prevention

Maher, L., Tachedjian, G., Hoy, J. F., Millwood, I., Guy, R. J., Walsh, N. M., Zaunders, J. J., Jaworowski, A. & Kaldor, J. M., 1 Dec 2007, In : Medical Journal of Australia. 187, 11-12, p. 610-612 3 p.

Research output: Contribution to journalArticleResearchpeer-review

23 Citations (Scopus)

Influence of IFNγ co-expression on the safety and antiviral efficacy of recombinant fowlpox virus HIV therapeutic vaccines following interruption of antiretroviral therapy

Emery, S., Kelleher, A. D., Workman, C., Puls, R. L., Bloch, M., Baker, D., Anderson, J., Hoy, J., Ip, S., Nalliah, K., Ward, L. D., Law, M. G. & Cooper, D. A., 1 Jan 2007, In : Human Vaccines. 3, 6, p. 260-267 8 p.

Research output: Contribution to journalArticleResearchpeer-review