Research Output 2015 2019

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2019

Modification of the cyclopropyl moiety of abacavir provides insight into the structure activity relationship between HLA-B*57:01 binding and T-cell activation

Thomson, P. J., Illing, P. T., Farrell, J., Alhaidari, M., Bell, C. C., Berry, N., O’Neill, P. M., Purcell, A. W., Park, K. B. & Naisbitt, D. J., 24 Sep 2019, (Accepted/In press) In : Allergy. 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Molecular Basis of Unexpected Specificity of ABC Transporter-Associated Substrate-Binding Protein DppA from Helicobacter pylori

Rahman, M. M., Machuca, M. A., Khan, M. F., Barlow, C. K., Schittenhelm, R. B. & Roujeinikova, A., 15 Oct 2019, In : Journal of Bacteriology. 201, 20, 18 p., e00400-19.

Research output: Contribution to journalArticleResearchpeer-review

2 Citations (Scopus)

Molecular dissection of an inhibitor targeting the HIV integrase dependent preintegration complex nuclear import

Wagstaff, K. M., Headey, S., Telwatte, S., Tyssen, D., Hearps, A. C., Thomas, D. R., Tachedjian, G. & Jans, D. A., Jan 2019, In : Cellular Microbiology. 21, 1, 13 p., e12953.

Research output: Contribution to journalArticleResearchpeer-review

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3 Citations (Scopus)

Most viral peptides displayed by class I MHC on infected cells are immunogenic

Croft, N. P., Smith, S. A., Pickering, J., Sidney, J., Peters, B., Faridi, P., Witney, M. J., Sebastian, P., Flesch, I. E. A., Heading, S. L., Sette, A., La Gruta, N. L., Purcell, A. W. & Tscharke, D. C., 19 Feb 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 116, 8, p. 3112-3117 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Motilimonas pumila sp. Nov., isolated from the gut of sea cucumber apostichopus japonicus

Wang, F. Q., Ren, L. H., Lin, Y-W., Sun, G. H., Du, Z. J., Zhao, J-X., Liu, X. J. & Liu, L. J., 1 Mar 2019, In : International Journal of Systematic and Evolutionary Microbiology. 69, 3, p. 811-815 5 p., 003242.

Research output: Contribution to journalArticleResearchpeer-review

Novel Flavivirus Antiviral That Targets the Host Nuclear Transport Importin α/β1 Heterodimer

Yang, S. N. Y., Atkinson, S. C., Fraser, J. E., Wang, C., Maher, B., Roman, N., Forwood, J. K., Wagstaff, K. M., Borg, N. A. & Jans, D. A., 24 Mar 2019, In : Cells. 8, 3, 15 p., 281.

Research output: Contribution to journalArticleResearchpeer-review

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Novel Human Aminopeptidase N Inhibitors: Discovery and Optimization of Subsite Binding Interactions

Lee, J., Vinh, N. B., Drinkwater, N., Yang, W., Kannan Sivaraman, K., Schembri, L. S., Gazdik, M., Grin, P. M., Butler, G. S., Overall, C. M., Charman, S. A., McGowan, S. & Scammells, P. J., 8 Aug 2019, In : Journal of Medicinal Chemistry. 62, 15, p. 7185-7209 25 p.

Research output: Contribution to journalArticleResearchpeer-review

Novel polymyxin combination with the antiretroviral zidovudine exerts synergistic killing against Ndm-producing multidrug-resistant klebsiella pneumoniae

Lin, Y-W., Rahim, N. A., Zhao, J., Han, M-L., Yu, H. H., Wickremasinghe, H., Chen, K., Wang, J., Paterson, D. L., Zhu, Y., Rao, G. G., Zhou, Q. T., Forrest, A., Velkov, T. & Li, J., 1 Apr 2019, In : Antimicrobial Agents and Chemotherapy. 63, 4, 11 p., e02176-18.

Research output: Contribution to journalArticleResearchpeer-review

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1 Citation (Scopus)

pCP13, a representative of a new family of conjugative toxin plasmids in Clostridium perfringens

Watts, T. D., Vidor, C. J., Awad, M. M., Lyras, D., Rood, J. I. & Adams, V., 1 Mar 2019, In : Plasmid. 102, p. 37-45 9 p.

Research output: Contribution to journalArticleResearchpeer-review

1 Citation (Scopus)

PD-L1– and calcitriol-dependent liposomal antigen-specific regulation of systemic inflammatory autoimmune disease

Galea, R., Nel, H. J., Talekar, M., Liu, X., Ooi, J. D., Huynh, M., Hadjigol, S., Robson, K. J., Ting, Y. T., Cole, S., Cochlin, K., Hitchcock, S., Zeng, B., Yekollu, S., Boks, M., Goh, N., Roberts, H., Rossjohn, J., Reid, H. H., Boyd, B. J. & 7 others, Malaviya, R., Shealy, D. J., Baker, D. G., Madakamutil, L., Richard Kitching, A., O’Sullivan, B. J. & Thomas, R., 19 Sep 2019, In : JCI Insight. 4, 18, 21 p., e126025.

Research output: Contribution to journalArticleResearchpeer-review

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PeNGaRoo, a combined gradient boosting and ensemble learning framework for predicting non-classical secreted proteins

Zhang, Y., Yu, S., Xie, R., Li, J., Leier, A., Marquez-Lago, T. T., Akutsu, T., Smith, A. I., Ge, Z., Wang, J., Lithgow, T. & Song, J., 8 Aug 2019, (Accepted/In press) In : Bioinformatics. 8 p., btz629.

Research output: Contribution to journalArticleResearchpeer-review

Polymyxin resistance in Klebsiella pneumoniae: multifaceted mechanisms utilized in the presence and absence of the plasmid-encoded phosphoethanolamine transferase gene mcr-1

Nang, S. C., Han, M-L., Yu, H. H., Wang, J., Torres, V. V. L., Dai, C., Velkov, T., Harper, M. & Li, J., 1 Nov 2019, In : Journal of Antimicrobial Chemotherapy. 74, 11, p. 3190-3198 9 p.

Research output: Contribution to journalArticleResearchpeer-review

5 Citations (Scopus)

Porin Associates with Tom22 to Regulate the Mitochondrial Protein Gate Assembly

Sakaue, H., Shiota, T., Ishizaka, N., Kawano, S., Tamura, Y., Tan, K. S., Imai, K., Motono, C., Hirokawa, T., Taki, K., Miyata, N., Kuge, O., Lithgow, T. & Endo, T., 7 Mar 2019, In : Molecular Cell. 73, 5, p. 1044-1055 12 p.

Research output: Contribution to journalArticleResearchpeer-review

7 Citations (Scopus)

Positive-unlabelled learning of glycosylation sites in the human proteome

Li, F., Zhang, Y., Purcell, A. W., Webb, G. I., Chou, K-C., Lithgow, T., Li, C. & Song, J., 6 Mar 2019, In : BMC Bioinformatics. 20, 1, 17 p., 112.

Research output: Contribution to journalArticleResearchpeer-review

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PRISMOID: a comprehensive 3D structure database for post-translational modifications and mutations with functional impact

Li, F., Fan, C., Marquez-Lago, T. T., Leier, A., Revote, J., Jia, C., Zhu, Y., Smith, A. I., Webb, G. I., Liu, Q., Wei, L., Li, J. & Song, J., 4 Jun 2019, (Accepted/In press) In : Briefings in Bioinformatics. 11 p., bbz050.

Research output: Contribution to journalArticleResearchpeer-review

1 Citation (Scopus)

Rapid interferon independent expression of IFITM3 following T cell activation protects cells from influenza virus infection

Bedford, J. G., O’Keeffe, M., Reading, P. C. & Wakim, L. M., 16 Jan 2019, In : PLoS ONE. 14, 1, 12 p., e0210132.

Research output: Contribution to journalArticleResearchpeer-review

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1 Citation (Scopus)

Regulation of the b-adrenergic receptor signaling pathway in sustained ligand-activated preconditioning

See Hoe, L. E., Foster, S. R., Wendt, L., Patel, H. H., Headrick, J. P. & Peart, J. N., 1 Apr 2019, In : Journal of Pharmacology and Experimental Therapeutics. 369, 1, p. 37-46 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
2 Citations (Scopus)

Sensitization to immune checkpoint blockade through activation of a STAT1/NK axis in the tumor microenvironment

Zemek, R. M., De Jong, E., Chin, W. L., Schuster, I. S., Fear, V. S., Casey, T. H., Forbes, C., Dart, S. J., Leslie, C., Zaitouny, A., Small, M., Boon, L., Forrest, A. R. R., Muiri, D. O., Degli-Esposti, M. A., Millward, M. J., Nowak, A. K., Lassmann, T., Bosco, A., Lake, R. A. & 1 others, Lesterhuis, W. J., 17 Jul 2019, In : Science Translational Medicine. 11, 501, 13 p., eaav7816.

Research output: Contribution to journalArticleResearchpeer-review

Status of vaccine research and development for Clostridium difficile

Riley, T. V., Lyras, D. & Douce, G. R., 19 Mar 2019, (Accepted/In press) In : Vaccine. 7 p.

Research output: Contribution to journalArticleOtherpeer-review

6 Citations (Scopus)

Strain-specific antibody therapy prevents cytomegalovirus reactivation after transplantation

Martins, J. P., Andoniou, C. E., Fleming, P., Kuns, R. D., Schuster, I. S., Voigt, V., Daly, S., Varelias, A., Tey, S. K., Degli-Esposti, M. A. & Hill, G. R., 18 Jan 2019, In : Science. 363, 6424, p. 288-293 6 p.

Research output: Contribution to journalArticleResearchpeer-review

5 Citations (Scopus)

Structural Basis for CD96 Immune Receptor Recognition of Nectin-like Protein-5, CD155

Deuss, F. A., Watson, G. M., Fu, Z., Rossjohn, J. & Berry, R., 5 Feb 2019, In : Structure. 27, 2, p. 219-228 10 p.

Research output: Contribution to journalArticleResearchpeer-review

1 Citation (Scopus)

Structural basis for the recognition of nectin-like protein-5 by the human-activating immune receptor, DNAM-1

Deuss, F. A., Watson, G. M., Goodall, K. J., Leece, I., Chatterjee, S., Fu, Z., Thaysen-Andersen, M., Andrews, D. M., Rossjohn, J. & Berry, R., 16 Aug 2019, In : Journal of Biological Chemistry. 294, 33, p. 12534-12546 13 p.

Research output: Contribution to journalArticleResearchpeer-review

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Synergistic Combination of Polymyxin B and Enrofloxacin Induced Metabolic Perturbations in Extensive Drug-resistant Pseudomonas aeruginosa

Lin, Y-W., Han, M-L., Zhao, J., Zhu, Y., Rao, G., Forrest, A., Song, J., Kaye, K. S., Hertzog, P., Purcell, A., Creek, D., Zhou, T. Q., Velkov, T. & Li, J., 3 Oct 2019, In : Frontiers in Pharmacology. 10, 11 p., 1146.

Research output: Contribution to journalArticleResearchpeer-review

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1 Citation (Scopus)

The early proximal TCR signalosome specifies thymic selection outcome through a quantitative protein interaction network

Neier, S. C., Ferrer, A., Wilton, K. M., Smith, S. E. P., Kelcher, A. M. H., Pavelko, K. D., Canfield, J. M., Davis, T. R., Stiles, R. J., Chen, Z., McCluskey, J., Burrows, S. R., Rossjohn, J., Hebrink, D. M., Carmona, E. M., Limper, A. H., Kappes, D. J., Wettstein, P. J., Johnson, A. J., Pease, L. R. & 4 others, Daniels, M. A., Neuhauser, C., Gil, D. & Schrum, A. G., 15 Feb 2019, In : Science Immunology. 4, 32, 15 p., eaal2201.

Research output: Contribution to journalArticleResearchpeer-review

The Evolving Landscape of Autoantigen Discovery and Characterization in Type 1 Diabetes

Purcell, A. W., Sechi, S. & DiLorenzo, T. P., 1 May 2019, In : Diabetes. 68, 5, p. 879-886 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Therapeutic blockade of activin-A improves NK cell function and antitumor immunity

Rautela, J., Dagley, L. F., De Oliveira, C. C., Schuster, I. S., Hediyeh-Zadeh, S., Delconte, R. B., Cursons, J., Hennessy, R., Hutchinson, D. S., Harrison, C., Kita, B., Vivier, E., Webb, A. I., Degli-Esposti, M. A., Davis, M. J., Huntington, N. D. & Souza-Fonseca-Guimaraes, F., 27 Aug 2019, In : Science Signaling. 12, 596, 13 p., aat7527.

Research output: Contribution to journalArticleResearchpeer-review

1 Citation (Scopus)

The TAM: A Translocation and Assembly Module of the β-Barrel Assembly Machinery in Bacterial Outer Membranes

Stubenrauch, C. J. & Lithgow, T., 27 Feb 2019, In : EcoSal Plus. 8, 2, 7 p.

Research output: Contribution to journalArticleResearchpeer-review

5 Citations (Scopus)

Type I interferon induces CXCL13 to support ectopic germinal center formation

Denton, A. E., Innocentin, S., Carr, E. J., Bradford, B. M., Lafouresse, F., Mabbott, N. A., Mörbe, U., Ludewig, B., Groom, J. R., Good-Jacobson, K. L. & Linterman, M. A., 4 Mar 2019, In : The Journal of experimental medicine. 216, 3, p. 621-637 17 p.

Research output: Contribution to journalArticleResearchpeer-review

Virulence Plasmids of the Pathogenic Clostridia

Revitt-Mills, S. A., Vidor, C. J., Watts, T. D., Lyras, D., Rood, J. I. & Adams, V., 17 May 2019, In : Microbiology spectrum. 7, 3, 28 p., GPP3-0034-2018.

Research output: Contribution to journalArticleResearchpeer-review

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1 Citation (Scopus)

Zymosan by-passes the requirement for pulmonary antigen encounter in lung tissue-resident memory CD8+ T cell development

Caminschi, I., Lahoud, M. H., Pizzolla, A. & Wakim, L. M., 21 Jan 2019, In : Mucosal Immunology. 12, p. 403-412 10 p.

Research output: Contribution to journalArticleResearchpeer-review

2018

A laboratory competency examination in microbiology

Wang, J. T. H., Huston, W. M., Johanesen, P., Lloyd, M. & Waller, K. L., 1 Oct 2018, In : FEMS Microbiology Letters. 365, 20, 9 p., fny224.

Research output: Contribution to journalArticleResearchpeer-review

4 Citations (Scopus)

A Metabolic Checkpoint for the Yeast-to-Hyphae Developmental Switch Regulated by Endogenous Nitric Oxide Signaling

Koch, B., Barugahare, A. A., Lo, T. L., Huang, C., Schittenhelm, R. B., Powell, D. R., Beilharz, T. H. & Traven, A., 20 Nov 2018, In : Cell Reports. 25, 8, p. 2244-2258 15 p.

Research output: Contribution to journalArticleResearchpeer-review

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10 Citations (Scopus)

An insight into intestinal mucosal microbiota disruption after stroke

Stanley, D., Moore, R. J. & Wong, C. H. Y., 1 Dec 2018, In : Scientific Reports. 8, 1, 12 p., 568.

Research output: Contribution to journalArticleResearchpeer-review

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1 Citation (Scopus)

An investigation into the Omp85 protein BamK in hypervirulent Klebsiella pneumoniae, and its role in outer membrane biogenesis

Torres, V. V. L., Heinz, E., Stubenrauch, C. J., Wilksch, J. J., Cao, H., Yang, J., Clements, A., Dunstan, R. A., Alcock, F., Webb, C. T., Dougan, G., Strugnell, R. A., Hay, I. D. & Lithgow, T., Sep 2018, In : Molecular Microbiology. 109, 5, p. 584-599 16 p.

Research output: Contribution to journalArticleResearchpeer-review

2 Citations (Scopus)

Annexin V-containing cubosomes for targeted early detection of apoptosis in degenerative retinal tissue

Ding, Y., Chow, S. H., Liu, G. S., Wang, B., Lin, T. W., Hsu, H. Y., Duff, A. P., Le Brun, A. P. & Shen, H. H., 2018, In : Journal of Materials Chemistry B. 6, 46, p. 7652-7661 10 p.

Research output: Contribution to journalArticleResearchpeer-review

10 Citations (Scopus)

An overview on the identification of MAIT cell antigens

Kjer-Nielsen, L., Corbett, A. J., Chen, Z., Liu, L., Mak, J. Y., Godfrey, D. I., Rossjohn, J., Fairlie, D. P., Mccluskey, J. & Eckle, S. B., Jul 2018, In : Immunology and Cell Biology. 96, 6, p. 573-587 15 p.

Research output: Contribution to journalArticleResearchpeer-review

Assessing the role of the T-box transcription factor Eomes in B cell differentiation during either Th1 or Th2 cell-biased responses

Cooper, L., Hailes, L., Sheikh, A., Zaph, C., Belz, G. T., Groom, J. R. & Good-Jacobson, K. L., 6 Dec 2018, In : PLoS ONE. 13, 12, 11 p., e0208343.

Research output: Contribution to journalArticleResearchpeer-review

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18 Citations (Scopus)

A subset of HLA-I peptides are not genomically templated: Evidence for cis- and trans-spliced peptide ligands

Faridi, P., Li, C., Ramarathinam, S. H., Vivian, J. P., Illing, P. T., Mifsud, N. A., Ayala, R., Song, J., Gearing, L. J., Hertzog, P. J., Ternette, N., Rossjohn, J., Croft, N. P. & Purcell, A. W., 12 Oct 2018, In : Science Immunology. 3, 28, 12 p., eaar3947.

Research output: Contribution to journalArticleResearchpeer-review

1 Citation (Scopus)

A System Pharmacology Study for Deciphering Anti Depression Activity of Nardostachys jatamansi

Jalali, S., Zarrinhaghighi, A., Sadraei, S., Ghasemi, Y., Sakhteman, A. & Faridi, P., 1 Jan 2018, In : Current Drug Metabolism. 19, 5, p. 469-476 8 p.

Research output: Contribution to journalArticleResearchpeer-review

29 Citations (Scopus)

Bastion6: A bioinformatics approach for accurate prediction of type VI secreted effectors

Wang, J., Yang, B., Leier, A., Marquez-Lago, T., Hayashida, M., Rocker, A., Zhang, Y., Akutsu, T., Chou, K-C., Strugnell, R. A., Song, J. & Lithgow, T., 1 Jan 2018, In : Bioinformatics. 34, 15, p. 2546-2555 10 p.

Research output: Contribution to journalArticleResearchpeer-review

2 Citations (Scopus)

Broad CD8+ T cell cross-recognition of distinct influenza A strains in humans

Grant, E. J., Josephs, T. M., Loh, L., Clemens, E. B., Sant, S., Bharadwaj, M., Chen, W., Rossjohn, J., Gras, S. & Kedzierska, K., 21 Dec 2018, In : Nature Communications. 9, 1, 16 p., 5427.

Research output: Contribution to journalArticleResearchpeer-review

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5 Citations (Scopus)

CD8+ T Cell Activation Leads to Constitutive Formation of Liver Tissue-Resident Memory T Cells that Seed a Large and Flexible Niche in the Liver

Holz, L. E., Prier, J. E., Freestone, D., Steiner, T. M., English, K., Johnson, D. N., Mollard, V., Cozijnsen, A., Davey, G. M., Godfrey, D. I., Yui, K., Mackay, L. K., Lahoud, M. H., Caminschi, I., McFadden, G. I., Bertolino, P., Fernandez-Ruiz, D. & Heath, W. R., 2 Oct 2018, In : Cell Reports. 25, 1, p. 68-79 13 p.

Research output: Contribution to journalArticleResearchpeer-review

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Characteristic and mechanism of immobilization effect of Staphylococcus aureus on human spermatozoa

Li, J., Li, B., Song, J., Liu, H., Bi, W., Dong, G. & Zhou, T., 1 Jun 2018, In : Microbial Pathogenesis. 119, p. 28-34 7 p.

Research output: Contribution to journalArticleResearchpeer-review

1 Citation (Scopus)

Characterization of Plasmodium falciparum Atypical Kinase PfPK7- Dependent Phosphoproteome

Pease, B. N., Huttlin, E. L., Jedrychowski, M. P., Dorin-Semblat, D., Sebastiani, D., Segarra, D. T., Roberts, B. F., Chakrabarti, R., Doerig, C., Gygi, S. P. & Chakrabarti, D., 1 Jun 2018, In : Journal of Proteome Research. 17, 6, p. 2112-2123 12 p.

Research output: Contribution to journalArticleResearchpeer-review

12 Citations (Scopus)

Clonally diverse CD38+HLA-DR+CD8+ T cells persist during fatal H7N9 disease

Wang, Z., Zhu, L., Nguyen, T. H. O., Wan, Y., Sant, S., Quiñones-Parra, S. M., Crawford, J. C., Eltahla, A. A., Rizzetto, S., Bull, R. A., Qiu, C., Koutsakos, M., Clemens, E. B., Loh, L., Chen, T., Liu, L., Cao, P., Ren, Y., Kedzierski, L., Kotsimbos, T. & 10 others, McCaw, J. M., La Gruta, N. L., Turner, S. J., Cheng, A. C., Luciani, F., Zhang, X., Doherty, P. C., Thomas, P. G., Xu, J. & Kedzierska, K., 26 Feb 2018, In : Nature Communications. 9, 1, 12 p., 824.

Research output: Contribution to journalArticleResearchpeer-review

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Clostridium perfringens-mediated necrotic enteritis is not influenced by the pre-existing microbiota but is promoted by large changes in the post-challenge microbiota

Lacey, J. A., Stanley, D., Keyburn, A. L., Ford, M., Chen, H., Johanesen, P., Lyras, D. & Moore, R. J., 1 Dec 2018, In : Veterinary Microbiology. 227, p. 119-126 8 p.

Research output: Contribution to journalArticleResearchpeer-review

3 Citations (Scopus)

Clostridium sordellii outer spore proteins maintain spore structural integrity and promote bacterial clearance from the gastrointestinal tract

Rabi, R., Larcombe, S., Mathias, R., McGowan, S., Awad, M. & Lyras, D., 18 Apr 2018, In : PLoS Pathogens. 14, 4, 25 p., e1007004.

Research output: Contribution to journalArticleResearchpeer-review

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5 Citations (Scopus)

Clostridium sordellii pathogenicity locus plasmid pCS1-1 encodes a novel clostridial conjugation locus

Vidor, C. J., Watts, T. D., Adams, V., Bulach, D., Couchman, E., Rood, J. I., Fairweather, N. F., Awad, M. & Lyras, D., 16 Jan 2018, In : mBio. 9, 1, 14 p., e01761-17.

Research output: Contribution to journalArticleResearchpeer-review

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