Research Output 2015 2020

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2019
1 Citation (Scopus)

Identification of Novel Acinetobacter baumannii Host Fatty Acid Stress Adaptation Strategies

Jiang, J. H., Hassan, K. A., Begg, S. L., Rupasinghe, T. W. T., Naidu, V., Pederick, V. G., Khorvash, M., Whittall, J. J., Paton, J. C., Paulsen, I. T., McDevitt, C. A., Peleg, A. Y. & Eijkelkamp, B. A., 5 Feb 2019, In : mBio. 10, 1, 6 p., e02056-18.

Research output: Contribution to journalArticleResearchpeer-review

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2 Citations (Scopus)

IL-33 augments virus-specific memory T cell inflation and potentiates the efficacy of an attenuated cytomegalovirus-based vaccine

McLaren, J. E., Clement, M., Marsden, M., Miners, K. L., Llewellyn-Lacey, S., Grant, E. J., Rubina, A., Gimeno Brias, S., Gostick, E., Stacey, M. A., Orr, S. J., Stanton, R. J., Ladell, K., Price, D. A. & Humphreys, I. R., 1 Feb 2019, In : Journal of Immunology. 202, 3, p. 943-955 13 p.

Research output: Contribution to journalArticleResearchpeer-review

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1 Citation (Scopus)

Influence of Chemokine N-Terminal Modification on Biased Agonism at the Chemokine Receptor CCR1

Sanchez, J., Lane, J. R., Canals, M. & Stone, M. J., 15 May 2019, In : International Journal of Molecular Sciences. 20, 10, 15 p., 2417.

Research output: Contribution to journalArticleResearchpeer-review

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Inhibition of bioenergetics provides novel insights into recruitment of PINK1-dependent neuronal mitophagy

Shin, Y. S., Ryall, J. G., Britto, J. M., Lau, C. L., Devenish, R. J., Nagley, P. & Beart, P. M., Apr 2019, In : Journal of Neurochemistry. 149, 2, p. 269-283 15 p.

Research output: Contribution to journalArticleResearchpeer-review

In silico identification of novel toxin homologs and associated mobile genetic elements in clostridium perfringens

Lacey, J. A., Johanesen, P. A., Lyras, D. & Moore, R. J., 29 Jan 2019, In : Pathogens. 8, 1, 14 p., 16.

Research output: Contribution to journalArticleResearchpeer-review

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1 Citation (Scopus)

Lectin activity of the TcdA and TcdB toxins of Clostridium difficile

Hartley-Tassell, L. E., Awad, M. M., Seib, K. L., Scarselli, M., Savino, S., Tiralongo, J., Lyras, D., Day, C. J. & Jennings, M. P., 1 Mar 2019, In : Infection and Immunity. 87, 3, 9 p., e00676-18.

Research output: Contribution to journalArticleResearchpeer-review

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Mass spectrometry–based identification of MHC-bound peptides for immunopeptidomics

Purcell, A. W., Ramarathinam, S. H. & Ternette, N., Jun 2019, In : Nature Protocols. 14, 21 p.

Research output: Contribution to journalArticleResearchpeer-review

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Modification of the cyclopropyl moiety of abacavir provides insight into the structure activity relationship between HLA-B*57:01 binding and T-cell activation

Thomson, P. J., Illing, P. T., Farrell, J., Alhaidari, M., Bell, C. C., Berry, N., O’Neill, P. M., Purcell, A. W., Park, K. B. & Naisbitt, D. J., 24 Sep 2019, (Accepted/In press) In : Allergy. 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Molecular Basis of Unexpected Specificity of ABC Transporter-Associated Substrate-Binding Protein DppA from Helicobacter pylori

Rahman, M. M., Machuca, M. A., Khan, M. F., Barlow, C. K., Schittenhelm, R. B. & Roujeinikova, A., 15 Oct 2019, In : Journal of Bacteriology. 201, 20, 18 p., e00400-19.

Research output: Contribution to journalArticleResearchpeer-review

2 Citations (Scopus)

Molecular dissection of an inhibitor targeting the HIV integrase dependent preintegration complex nuclear import

Wagstaff, K. M., Headey, S., Telwatte, S., Tyssen, D., Hearps, A. C., Thomas, D. R., Tachedjian, G. & Jans, D. A., Jan 2019, In : Cellular Microbiology. 21, 1, 13 p., e12953.

Research output: Contribution to journalArticleResearchpeer-review

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3 Citations (Scopus)

Most viral peptides displayed by class I MHC on infected cells are immunogenic

Croft, N. P., Smith, S. A., Pickering, J., Sidney, J., Peters, B., Faridi, P., Witney, M. J., Sebastian, P., Flesch, I. E. A., Heading, S. L., Sette, A., La Gruta, N. L., Purcell, A. W. & Tscharke, D. C., 19 Feb 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 116, 8, p. 3112-3117 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Motilimonas pumila sp. Nov., isolated from the gut of sea cucumber apostichopus japonicus

Wang, F. Q., Ren, L. H., Lin, Y-W., Sun, G. H., Du, Z. J., Zhao, J-X., Liu, X. J. & Liu, L. J., 1 Mar 2019, In : International Journal of Systematic and Evolutionary Microbiology. 69, 3, p. 811-815 5 p., 003242.

Research output: Contribution to journalArticleResearchpeer-review

Multifaceted mechanisms of colistin resistance revealed by genomic analysis of multidrug-resistant Klebsiella pneumoniae isolates from individual patients before and after colistin treatment

Zhu, Y., Galani, I., Karaiskos, I., Lu, J., Aye, S. M., Huang, J., Yu, H. H., Velkov, T., Giamarellou, H. & Li, J., 1 Oct 2019, In : Journal of Infection. 79, 4, p. 312-321 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Novel Flavivirus Antiviral That Targets the Host Nuclear Transport Importin α/β1 Heterodimer

Yang, S. N. Y., Atkinson, S. C., Fraser, J. E., Wang, C., Maher, B., Roman, N., Forwood, J. K., Wagstaff, K. M., Borg, N. A. & Jans, D. A., 24 Mar 2019, In : Cells. 8, 3, 15 p., 281.

Research output: Contribution to journalArticleResearchpeer-review

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Novel Human Aminopeptidase N Inhibitors: Discovery and Optimization of Subsite Binding Interactions

Lee, J., Vinh, N. B., Drinkwater, N., Yang, W., Kannan Sivaraman, K., Schembri, L. S., Gazdik, M., Grin, P. M., Butler, G. S., Overall, C. M., Charman, S. A., McGowan, S. & Scammells, P. J., 8 Aug 2019, In : Journal of Medicinal Chemistry. 62, 15, p. 7185-7209 25 p.

Research output: Contribution to journalArticleResearchpeer-review

Novel polymyxin combination with the antiretroviral zidovudine exerts synergistic killing against Ndm-producing multidrug-resistant klebsiella pneumoniae

Lin, Y-W., Rahim, N. A., Zhao, J., Han, M-L., Yu, H. H., Wickremasinghe, H., Chen, K., Wang, J., Paterson, D. L., Zhu, Y., Rao, G. G., Zhou, Q. T., Forrest, A., Velkov, T. & Li, J., 1 Apr 2019, In : Antimicrobial Agents and Chemotherapy. 63, 4, 11 p., e02176-18.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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1 Citation (Scopus)

pCP13, a representative of a new family of conjugative toxin plasmids in Clostridium perfringens

Watts, T. D., Vidor, C. J., Awad, M. M., Lyras, D., Rood, J. I. & Adams, V., 1 Mar 2019, In : Plasmid. 102, p. 37-45 9 p.

Research output: Contribution to journalArticleResearchpeer-review

1 Citation (Scopus)

PD-L1– and calcitriol-dependent liposomal antigen-specific regulation of systemic inflammatory autoimmune disease

Galea, R., Nel, H. J., Talekar, M., Liu, X., Ooi, J. D., Huynh, M., Hadjigol, S., Robson, K. J., Ting, Y. T., Cole, S., Cochlin, K., Hitchcock, S., Zeng, B., Yekollu, S., Boks, M., Goh, N., Roberts, H., Rossjohn, J., Reid, H. H., Boyd, B. J. & 7 others, Malaviya, R., Shealy, D. J., Baker, D. G., Madakamutil, L., Richard Kitching, A., O’Sullivan, B. J. & Thomas, R., 19 Sep 2019, In : JCI Insight. 4, 18, 21 p., e126025.

Research output: Contribution to journalArticleResearchpeer-review

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PeNGaRoo, a combined gradient boosting and ensemble learning framework for predicting non-classical secreted proteins

Zhang, Y., Yu, S., Xie, R., Li, J., Leier, A., Marquez-Lago, T. T., Akutsu, T., Smith, A. I., Ge, Z., Wang, J., Lithgow, T. & Song, J., 8 Aug 2019, (Accepted/In press) In : Bioinformatics. 8 p., btz629.

Research output: Contribution to journalArticleResearchpeer-review

Polymyxin resistance in Klebsiella pneumoniae: multifaceted mechanisms utilized in the presence and absence of the plasmid-encoded phosphoethanolamine transferase gene mcr-1

Nang, S. C., Han, M-L., Yu, H. H., Wang, J., Torres, V. V. L., Dai, C., Velkov, T., Harper, M. & Li, J., 1 Nov 2019, In : Journal of Antimicrobial Chemotherapy. 74, 11, p. 3190-3198 9 p.

Research output: Contribution to journalArticleResearchpeer-review

5 Citations (Scopus)

Porin Associates with Tom22 to Regulate the Mitochondrial Protein Gate Assembly

Sakaue, H., Shiota, T., Ishizaka, N., Kawano, S., Tamura, Y., Tan, K. S., Imai, K., Motono, C., Hirokawa, T., Taki, K., Miyata, N., Kuge, O., Lithgow, T. & Endo, T., 7 Mar 2019, In : Molecular Cell. 73, 5, p. 1044-1055 12 p.

Research output: Contribution to journalArticleResearchpeer-review

7 Citations (Scopus)

Positive-unlabelled learning of glycosylation sites in the human proteome

Li, F., Zhang, Y., Purcell, A. W., Webb, G. I., Chou, K-C., Lithgow, T., Li, C. & Song, J., 6 Mar 2019, In : BMC Bioinformatics. 20, 1, 17 p., 112.

Research output: Contribution to journalArticleResearchpeer-review

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PRISMOID: a comprehensive 3D structure database for post-translational modifications and mutations with functional impact

Li, F., Fan, C., Marquez-Lago, T. T., Leier, A., Revote, J., Jia, C., Zhu, Y., Smith, A. I., Webb, G. I., Liu, Q., Wei, L., Li, J. & Song, J., 4 Jun 2019, (Accepted/In press) In : Briefings in Bioinformatics. 11 p., bbz050.

Research output: Contribution to journalArticleResearchpeer-review

1 Citation (Scopus)

Rapid interferon independent expression of IFITM3 following T cell activation protects cells from influenza virus infection

Bedford, J. G., O’Keeffe, M., Reading, P. C. & Wakim, L. M., 16 Jan 2019, In : PLoS ONE. 14, 1, 12 p., e0210132.

Research output: Contribution to journalArticleResearchpeer-review

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1 Citation (Scopus)

Regulation of the b-adrenergic receptor signaling pathway in sustained ligand-activated preconditioning

See Hoe, L. E., Foster, S. R., Wendt, L., Patel, H. H., Headrick, J. P. & Peart, J. N., 1 Apr 2019, In : Journal of Pharmacology and Experimental Therapeutics. 369, 1, p. 37-46 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
3 Citations (Scopus)

Sensitization to immune checkpoint blockade through activation of a STAT1/NK axis in the tumor microenvironment

Zemek, R. M., De Jong, E., Chin, W. L., Schuster, I. S., Fear, V. S., Casey, T. H., Forbes, C., Dart, S. J., Leslie, C., Zaitouny, A., Small, M., Boon, L., Forrest, A. R. R., Muiri, D. O., Degli-Esposti, M. A., Millward, M. J., Nowak, A. K., Lassmann, T., Bosco, A., Lake, R. A. & 1 others, Lesterhuis, W. J., 17 Jul 2019, In : Science Translational Medicine. 11, 501, 13 p., eaav7816.

Research output: Contribution to journalArticleResearchpeer-review

SIMLIN: a bioinformatics tool for prediction of S-sulphenylation in the human proteome based on multi-stage ensemble-learning models

Wang, X., Li, C., Li, F., Sharma, V. S., Song, J. & Webb, G. I., 21 Nov 2019, (Accepted/In press) In : BMC Bioinformatics. 12 p., 602.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Status of vaccine research and development for Clostridium difficile

Riley, T. V., Lyras, D. & Douce, G. R., 28 Nov 2019, In : Vaccine. 37, 50, p. 7300-7306 7 p.

Research output: Contribution to journalArticleOtherpeer-review

6 Citations (Scopus)

Strain-specific antibody therapy prevents cytomegalovirus reactivation after transplantation

Martins, J. P., Andoniou, C. E., Fleming, P., Kuns, R. D., Schuster, I. S., Voigt, V., Daly, S., Varelias, A., Tey, S. K., Degli-Esposti, M. A. & Hill, G. R., 18 Jan 2019, In : Science. 363, 6424, p. 288-293 6 p.

Research output: Contribution to journalArticleResearchpeer-review

5 Citations (Scopus)

Structural Basis for CD96 Immune Receptor Recognition of Nectin-like Protein-5, CD155

Deuss, F. A., Watson, G. M., Fu, Z., Rossjohn, J. & Berry, R., 5 Feb 2019, In : Structure. 27, 2, p. 219-228 10 p.

Research output: Contribution to journalArticleResearchpeer-review

1 Citation (Scopus)

Structural basis for the recognition of nectin-like protein-5 by the human-activating immune receptor, DNAM-1

Deuss, F. A., Watson, G. M., Goodall, K. J., Leece, I., Chatterjee, S., Fu, Z., Thaysen-Andersen, M., Andrews, D. M., Rossjohn, J. & Berry, R., 16 Aug 2019, In : Journal of Biological Chemistry. 294, 33, p. 12534-12546 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Synergistic Combination of Polymyxin B and Enrofloxacin Induced Metabolic Perturbations in Extensive Drug-resistant Pseudomonas aeruginosa

Lin, Y-W., Han, M-L., Zhao, J., Zhu, Y., Rao, G., Forrest, A., Song, J., Kaye, K. S., Hertzog, P., Purcell, A., Creek, D., Zhou, T. Q., Velkov, T. & Li, J., 3 Oct 2019, In : Frontiers in Pharmacology. 10, 11 p., 1146.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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1 Citation (Scopus)

The early proximal TCR signalosome specifies thymic selection outcome through a quantitative protein interaction network

Neier, S. C., Ferrer, A., Wilton, K. M., Smith, S. E. P., Kelcher, A. M. H., Pavelko, K. D., Canfield, J. M., Davis, T. R., Stiles, R. J., Chen, Z., McCluskey, J., Burrows, S. R., Rossjohn, J., Hebrink, D. M., Carmona, E. M., Limper, A. H., Kappes, D. J., Wettstein, P. J., Johnson, A. J., Pease, L. R. & 4 others, Daniels, M. A., Neuhauser, C., Gil, D. & Schrum, A. G., 15 Feb 2019, In : Science Immunology. 4, 32, 15 p., eaal2201.

Research output: Contribution to journalArticleResearchpeer-review

1 Citation (Scopus)

The Evolving Landscape of Autoantigen Discovery and Characterization in Type 1 Diabetes

Purcell, A. W., Sechi, S. & DiLorenzo, T. P., 1 May 2019, In : Diabetes. 68, 5, p. 879-886 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Therapeutic blockade of activin-A improves NK cell function and antitumor immunity

Rautela, J., Dagley, L. F., De Oliveira, C. C., Schuster, I. S., Hediyeh-Zadeh, S., Delconte, R. B., Cursons, J., Hennessy, R., Hutchinson, D. S., Harrison, C., Kita, B., Vivier, E., Webb, A. I., Degli-Esposti, M. A., Davis, M. J., Huntington, N. D. & Souza-Fonseca-Guimaraes, F., 27 Aug 2019, In : Science Signaling. 12, 596, 13 p., aat7527.

Research output: Contribution to journalArticleResearchpeer-review

1 Citation (Scopus)

The TAM: A Translocation and Assembly Module of the β-Barrel Assembly Machinery in Bacterial Outer Membranes

Stubenrauch, C. J. & Lithgow, T., 27 Feb 2019, In : EcoSal Plus. 8, 2, 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Transcription Factor T-bet in B Cells Modulates Germinal Center Polarization and Antibody Affinity Maturation in Response to Malaria

Ly, A., Liao, Y., Pietrzak, H., Ioannidis, L. J., Sidwell, T., Gloury, R., Doerflinger, M., Triglia, T., Qin, R. Z., Groom, J. R., Belz, G. T., Good-Jacobson, K. L., Shi, W., Kallies, A. & Hansen, D. S., 19 Nov 2019, In : Cell Reports. 29, 8, p. 2257-2269 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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5 Citations (Scopus)

Type I interferon induces CXCL13 to support ectopic germinal center formation

Denton, A. E., Innocentin, S., Carr, E. J., Bradford, B. M., Lafouresse, F., Mabbott, N. A., Mörbe, U., Ludewig, B., Groom, J. R., Good-Jacobson, K. L. & Linterman, M. A., 4 Mar 2019, In : The Journal of experimental medicine. 216, 3, p. 621-637 17 p.

Research output: Contribution to journalArticleResearchpeer-review

Virulence Plasmids of the Pathogenic Clostridia

Revitt-Mills, S. A., Vidor, C. J., Watts, T. D., Lyras, D., Rood, J. I. & Adams, V., 17 May 2019, In : Microbiology spectrum. 7, 3, 28 p., GPP3-0034-2018.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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1 Citation (Scopus)

Zymosan by-passes the requirement for pulmonary antigen encounter in lung tissue-resident memory CD8+ T cell development

Caminschi, I., Lahoud, M. H., Pizzolla, A. & Wakim, L. M., 21 Jan 2019, In : Mucosal Immunology. 12, p. 403-412 10 p.

Research output: Contribution to journalArticleResearchpeer-review

2020

Expression and purification of recombinant mouse CRISP4 using a baculovirus system

Gaikwad, A. S., Lee Loh, K., O'Connor, A. E., Reid, H. H. & O'Bryan, M. K., 1 Mar 2020, In : Protein Expression and Purification. 167, 6 p., 105543.

Research output: Contribution to journalArticleResearchpeer-review