Hudson Institute - Department of Molecular and Translational Science

Research Output 1981 2019

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2019

A cell type-specific transcriptomic approach to map B cell and monocyte type I interferon-linked pathogenic signatures in Multiple Sclerosis

Severa, M., Rizzo, F., Srinivasan, S., Di Dario, M., Giacomini, E., Buscarinu, M. C., Cruciani, M., Etna, M. P., Sandini, S., Mechelli, R., Farina, A., Trivedi, P., Hertzog, P. J., Salvetti, M., Farina, C. & Coccia, E. M., 1 Jul 2019, In : Journal of Autoimmunity. 101, p. 1-16 16 p.

Research output: Contribution to journalArticleResearchpeer-review

2 Citations (Scopus)

Activin A target genes are differentially expressed between normal and neoplastic adult human testes: clues to gonocyte fate choice

Szarek, M., Bergmann, M., Konrad, L., Schuppe, H. C., Kliesch, S., Hedger, M. P. & Loveland, K. A. L., 1 Jan 2019, In : Andrology. 7, 1, p. 31-41 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Acute heat-treatment disrupts inhibin-related protein production and gene expression in the adult rat testis

Aldahhan, R. A., Stanton, P., Ludlow, H., de Kretser, D. & Hedger, M., 1 Dec 2019, In : Molecular and Cellular Endocrinology. 498, 12 p., 110546.

Research output: Contribution to journalArticleResearchpeer-review

1 Citation (Scopus)

ADAM17: An emerging therapeutic target for lung cancer

Saad, M. I., Rose-John, S. & Jenkins, B. J., 21 Aug 2019, In : Cancers. 11, 9, 28 p., 1218.

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2 Citations (Scopus)

ADAM17 selectively activates the IL-6 trans-signaling/ERK MAPK axis in KRAS-addicted lung cancer

Saad, M. I., Alhayyani, S., McLeod, L., Yu, L., Alanazi, M., Deswaerte, V., Tang, K., Jarde, T., Smith, J. A., Prodanovic, Z., Tate, M. D., Balic, J. J., Watkins, D. N., Cain, J. E., Bozinovski, S., Algar, E., Kohmoto, T., Ebi, H., Ferlin, W., Garbers, C. & 4 others, Ruwanpura, S., Sagi, I., Rose-John, S. & Jenkins, B. J., Apr 2019, In : EMBO Molecular Medicine. 11, 4, 19 p., e9976.

Research output: Contribution to journalArticleResearchpeer-review

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24 Citations (Scopus)

A human gut bacterial genome and culture collection for improved metagenomic analyses

Forster, S. C., Kumar, N., Anonye, B. O., Almeida, A., Viciani, E., Stares, M. D., Dunn, M., Mkandawire, T. T., Zhu, A., Shao, Y., Pike, L. J., Louie, T., Browne, H. P., Mitchell, A. L., Neville, B. A., Finn, R. D. & Lawley, T. D., 1 Feb 2019, In : Nature Biotechnology. 37, 2, p. 186-192 7 p.

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31 Citations (Scopus)

A new genomic blueprint of the human gut microbiota

Almeida, A., Mitchell, A. L., Boland, M., Forster, S. C., Gloor, G. B., Tarkowska, A., Lawley, T. D. & Finn, R. D., 25 Apr 2019, In : Nature. 568, 7753, p. 499-504 6 p.

Research output: Contribution to journalArticleResearchpeer-review

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A novel “embryo-endometrial” adhesion model can potentially predict “receptive” or “non-receptive” endometrium

Evans, J., Walker, K. J., Bilandzic, M., Kinnear, S. & Salamonsen, L., 27 Nov 2019, (Accepted/In press) In : Journal of Assisted Reproduction and Genetics. 12 p.

Research output: Contribution to journalArticleResearchpeer-review

1 Citation (Scopus)

Anti-Helicobacter pylori activity of ethoxzolamide

Modak, J. K., Tikhomirova, A., Gorrell, R. J., Rahman, M. M., Kotsanas, D., Korman, T. M., Garcia-Bustos, J., Kwok, T., Ferrero, R. L., Supuran, C. T. & Roujeinikova, A., 1 Dec 2019, In : Journal of Enzyme Inhibition and Medicinal Chemistry. 34, 1, p. 1660-1667 8 p.

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A structural "star" in interferon gamma signaling

Hertzog, P. J. & de Weerd, N. A., 1 May 2019, In : Immunology and Cell Biology. 97, 5, p. 442-444 3 p.

Research output: Contribution to journalArticleOtherpeer-review

Open Access
2 Citations (Scopus)

Cisplatin- and cyclophosphamide-induced primordial follicle depletion is caused by direct damage to oocytes

Nguyen, QN., Zerafa, N., Liew, J., Findlay, J. K., Hickey, M. & Hutt, K., 1 Aug 2019, In : Molecular Human Reproduction. 25, 8, p. 433-444 12 p.

Research output: Contribution to journalArticleResearchpeer-review

3 Citations (Scopus)

Combined PPARγ Activation and XIAP Inhibition as a Potential Therapeutic Strategy for Ovarian Granulosa Cell Tumors

Leung, D. T. H., Nguyen, T., Oliver, E. M., Matti, J., Alexiadis, M., Silke, J., Jobling, T. W., Fuller, P. J. & Chu, S., 1 Feb 2019, In : Molecular Cancer Therapeutics. 18, 2, p. 364-375 12 p.

Research output: Contribution to journalArticleResearchpeer-review

2 Citations (Scopus)

Comparative metabolomics and transcriptomics reveal multiple pathways associated with polymyxin killing in pseudomonas aeruginosa

Han, M-L., Zhu, Y., Creek, D. J., Lin, Y-W., Gutu, A. D., Hertzog, P., Purcell, T., Shen, H-H., Moskowitz, S. M., Velkov, T. & Li, J., 1 Jan 2019, In : mSystems. 4, 1, 18 p., e00149-18.

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2 Citations (Scopus)

DDX5 plays essential transcriptional and post-transcriptional roles in the maintenance and function of spermatogonia

Legrand, J. M. D., Chan, A. L., La, H. M., Rossello, F., Anko, M-L., Fuller-Pace, F. V. & Hobbs, R., 1 Dec 2019, In : Nature Communications. 10, 1, 21 p., 2278.

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Deleting Suppressor of Cytokine Signaling-3 in chondrocytes reduces bone growth by disrupting mitogen-activated protein kinase signaling

Liu, X., D'Cruz, A. A., Hansen, J., Croker, B. A., Lawlor, K. E., Sims, N. A. & Wicks, I. P., 5 Jun 2019, (Accepted/In press) In : Osteoarthritis and Cartilage. 7 p.

Research output: Contribution to journalArticleResearchpeer-review

1 Citation (Scopus)

Effect of spontaneous breathing on umbilical venous blood flow and during delayed cord clamping in preterm lambs

Brouwer, E., Te Pas, A. B., Polglase, G. R., McGillick, E. V., Böhringer, S., Crossley, K. J., Rodgers, K., Blank, D., Yamaoka, S., Gill, A. W., Kluckow, M. & Hooper, S. B., 2 Apr 2019, (Accepted/In press) In : Archives of Disease in Childhood: Fetal and Neonatal Edition. 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Elevated protease HtrA4 in the maternal circulation of preeclampsia may contribute to endothelial barrier disruption by cleaving key junctional protein VE-cadherin

Tseng, E., Yee Teoh, S. S., Wang, Y. & Nie, G., 15 Jan 2019, In : Placenta. 76, 15, p. 51-53 3 p.

Research output: Contribution to journalArticleResearchpeer-review

Fetal growth restriction alters cerebellar development in fetal and neonatal sheep

Yawno, T., Sutherland, A. E., Pham, Y., Castillo-Melendez, M., Jenkin, G. & Miller, S., 22 May 2019, In : Frontiers in Physiology. 10, MAY, 12 p., 560.

Research output: Contribution to journalArticleResearchpeer-review

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2 Citations (Scopus)

High levels of HtrA4 detected in preeclamptic circulation may disrupt endothelial cell function by cleaving the main VEGFA receptor KDR

Wang, Y., La, M., Pham, T., Lovrecz, G. O. & Nie, G., 1 Apr 2019, In : FASEB Journal. 33, 4, p. 5058-5066 9 p.

Research output: Contribution to journalArticleResearchpeer-review

HtrA4 may play a major role in inhibiting endothelial repair in pregnancy complication preeclampsia

Wang, Y., Lim, R. & Nie, G., 1 Dec 2019, In : Scientific Reports. 9, 1, 14 p., 2728.

Research output: Contribution to journalArticleResearchpeer-review

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6 Citations (Scopus)

Interleukin 1 Up-regulates MicroRNA 135b to Promote Inflammation-Associated Gastric Carcinogenesis in Mice

Han, T. S., Voon, D. C. C., Oshima, H., Nakayama, M., Echizen, K., Sakai, E., Yong, Z. W. E., Murakami, K., Yu, L., Minamoto, T., Ock, C. Y., Jenkins, B. J., Kim, S. J., Yang, H. K. & Oshima, M., 1 Mar 2019, In : Gastroenterology. 156, 4, p. 1140-1155.e4 20 p.

Research output: Contribution to journalArticleResearchpeer-review

Interplay between Follistatin, Activin A, and BMP4 Signaling Regulates Postnatal Thymic Epithelial Progenitor Cell Differentiation during Aging

Lepletier, A., Hun, M. L., Hammett, M. V., Wong, K., Naeem, H., Hedger, M., Loveland, K. & Chidgey, A. P., 25 Jun 2019, In : Cell Reports. 27, 13, p. 3887–3901–e4 19 p.

Research output: Contribution to journalArticleResearchpeer-review

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Investigation of activin A in inflammatory responses of the testis and its role in the development of testicular fibrosis

Kauerhof, A. C., Nicolas, N., Bhushan, S., Wahle, E., Loveland, K. A., Fietz, D., Bergmann, M., Groome, N. P., Kliesch, S., Schuppe, H-C., Pilatz, A., Meinhardt, A., Hedger, M. P. & Fijak, M., 24 Jul 2019, (Accepted/In press) In : Human Reproduction. 15 p.

Research output: Contribution to journalArticleResearchpeer-review

Low Serum Levels of HtrA3 at 15 Weeks of Gestation Are Associated with Late-Onset Preeclampsia Development and Small for Gestational Age Birth

Teoh, S. S. Y., Wang, Y., Li, Y., Leemaqz, S. Y. L., Dekker, G. A., Roberts, C. T. & Nie, G., 3 Apr 2019, (Accepted/In press) In : Fetal Diagnosis and Therapy. 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Lupeol, the major compound of the dichloromethane extract of Millettia macrophylla Benth (Fabaceae), displays estrogenic effects in ovariectomized rats

Zingue, S., Ntsa, D. M., Magne Nde, C. B., Michel, T., Ndinteh, D. T., Clyne, C. & Njamen, D., 1 Apr 2019, In : Phytotherapy Research. 33, 4, p. 949-957 9 p.

Research output: Contribution to journalArticleResearchpeer-review

1 Citation (Scopus)

Measurement of Mitochondrial Membrane Potential with the Fluorescent Dye Tetramethylrhodamine Methyl Ester (TMRM)

Creed, S. & McKenzie, M., 1 Jan 2019, In : Methods in Molecular Biology. 1928, p. 69-76 8 p.

Research output: Contribution to journalArticleOtherpeer-review

1 Citation (Scopus)

Menstrual fluid factors facilitate tissue repair: identification and functional action in endometrial and skin repair

Evans, J., Infusini, G., McGovern, J., Cuttle, L., Webb, A., Nebl, T., Milla, L., Kimble, R., Kempf, M., Andrews, C. J., Leavesley, D. & Salamonsen, L. A., 1 Jan 2019, In : FASEB Journal. 33, 1, p. 584-605 22 p.

Research output: Contribution to journalArticleResearchpeer-review

MicroRNA from a 12-h versus 20-h acetylcysteine infusion for paracetamol overdose

Wong, A., Nejad, C., Gantier, M., Choy, K. W., Doery, J. & Graudins, A., 1 Jun 2019, In : Human and Experimental Toxicology. 38, 6, p. 646-654 9 p.

Research output: Contribution to journalArticleResearchpeer-review

2 Citations (Scopus)

miRNA length variation during macrophage stimulation confounds the interpretation of results: implications for miRNA quantification by RT-qPCR

Pillman, K. A., Goodall, G. J., Bracken, C. P. & Gantier, M. P., 1 Feb 2019, In : Rna-A Publication of the Rna Society. 25, 2, p. 232-238 7 p.

Research output: Contribution to journalArticleResearchpeer-review

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13 Citations (Scopus)

More than 18,000 effectors in the Legionella genus genome provide multiple, independent combinations for replication in human cells

Gomez-Valero, L., Rusniok, C., Carson, D., Mondino, S., Pérez-Cobas, A. E., Rolando, M., Pasricha, S., Reuter, S., Demirtas, J., Crumbach, J., Descorps-Declere, S., Hartland, E. L., Jarraud, S., Dougan, G., Schroeder, G. N., Frankel, G. & Buchrieser, C., 5 Feb 2019, In : Proceedings of the National Academy of Sciences. 116, 6, p. 2265-2273 9 p.

Research output: Contribution to journalArticleResearchpeer-review

1 Citation (Scopus)

Mutational landscape of ovarian adult granulosa cell tumors from whole exome and targeted TERT promoter sequencing

Alexiadis, M., Rowley, S. M., Chu, S., Leung, D. T. H., Stewart, C. J. R., Amarasinghe, K. C., Campbell, I. G. & Fuller, P. J., 1 Jan 2019, In : Molecular Cancer Research. 17, 1, p. 177-185 9 p.

Research output: Contribution to journalArticleResearchpeer-review

1 Citation (Scopus)

Non-invasive fluorescent monitoring of ovarian cancer in an immunocompetent mouse model

Wilson, A. L., Wilson, K. L., Bilandzic, M., Moffitt, L. R., Makanji, M., Gorrell, M. D., Oehler, M. K., Rainczuk, A., Stephens, A. N. & Plebanski, M., 1 Jan 2019, In : Cancers. 11, 1, 19 p., 32.

Research output: Contribution to journalArticleResearchpeer-review

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Normal foetal kidney volume in offspring of women treated for gestational diabetes

Hokke, S., De Zoysa, N., Carr, B. L., Abruzzo, V., Coombs, P. R., Allan, C. A., East, C., Ingelfinger, J., Puelles, V. G., Black, M. J., Ryan, D., Armitage, J. A., Wallace, E. M., Bertram, J. F. & Cullen-McEwen, L. A., Oct 2019, In : Endocrinology, Diabetes & Metabolism. 2, 4, 9 p., e00091.

Research output: Contribution to journalArticleResearchpeer-review

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2 Citations (Scopus)

Novel Application of the Pfirrmann Disc Degeneration Grading System to 9.4T MRI: Higher Reliability Compared to 3T MRI

Sher, I., Daly, C., Oehme, D., Chandra, R. V., Sher, M., Ghosh, P., Smith, J. & Goldschlager, T., 1 Jul 2019, In : Spine. 44, 13, p. E766-E773 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Pre‐pubertal growth, muscle and fat accumulation in male and female sheep – relationships with metabolic hormone concentrations, timing of puberty and reproductive outcomes

Rosales Nieto, C. A., Ferguson, M. B., Briegel, J. R., Hedger, M., Martin, G. B. & Thompson, A. N., 24 Sep 2019, (Accepted/In press) In : Reproduction in Domestic Animals. 20 p.

Research output: Contribution to journalArticleResearchpeer-review

Repurposing drugs targeting the P2X7 receptor to limit hyperinflammation and disease during influenza virus infection

Rosli, S., Kirby, F. J., Lawlor, K. E., Rainczuk, K., Drummond, G. R., Mansell, A. & Tate, M. D., Oct 2019, In : British Journal of Pharmacology. 176, 19, p. 3834-3844 11 p.

Research output: Contribution to journalArticleResearchpeer-review

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Open Access

Review: Helicobacter: Inflammation, immunology, and vaccines

Lehours, P. & Ferrero, R. L., 1 Sep 2019, In : Helicobacter. 24, S1, 6 p., e12644.

Research output: Contribution to journalArticleOtherpeer-review

RIPLET, and not TRIM25, is required for endogenous RIG-I-dependent antiviral responses

Hayman, T. J., Hsu, A. C., Kolesnik, T. B., Dagley, L. F., Willemsen, J., Tate, M. D., Baker, P. J., Kershaw, N. J., Kedzierski, L., Webb, A. I., Wark, P. A., Kedzierska, K., Masters, S. L., Belz, G. T., Binder, M., Hansbro, P. M., Nicola, N. A. & Nicholson, S. E., Oct 2019, In : Immunology and Cell Biology. 97, 9, p. 840-852 13 p.

Research output: Contribution to journalArticleResearchpeer-review

2 Citations (Scopus)

Salmonella effectors SseK1 and SseK3 target death domain proteins in the TNF and TRAIL signaling pathways

Newson, J., Scott, N. E., Chung, I. Y. W., Lung, T. W. F., Giogha, C., Gan, J., Wang, N., Strugnell, R., Brown, N. F., Cygler, M., Pearson, J. & Hartland, E., 1 Jun 2019, In : Molecular & Cellular Proteomics. 18, 6, p. 1138-1156 19 p.

Research output: Contribution to journalArticleResearchpeer-review

Serine-phosphorylated STAT3 promotes tumorigenesis via modulation of RNA polymerase transcriptional activity

Balic, J. J., Garama, D. J., Saad, M. I., Yu, L., West, A. C., West, A. J., Livis, T., Bhathal, P. S., Gough, D. J. & Jenkins, B. J., 15 Oct 2019, In : Cancer Research. 79, 20, p. 5272-5287 16 p.

Research output: Contribution to journalArticleResearchpeer-review

Serum podocalyxin at 11–13 weeks of gestation in the prediction of small for gestational age neonates

Rolnik, D. L., Wang, Y., Hyett, J., Silva Costa, F. D. & Nie, G., 1 Jun 2019, In : Journal of Perinatology. 39, 6, p. 784-790 7 p.

Research output: Contribution to journalArticleResearchpeer-review

SIDT1 localizes to endolysosomes and mediates double-stranded RNA transport into the cytoplasm

Nguyen, T. A., Smith, B. R. C., Elgass, K. D., Creed, S. J., Cheung, S., Tate, M. D., Belz, G. T., Wicks, I. P., Masters, S. L. & Pang, K. C., 15 Jun 2019, In : Journal of Immunology. 202, 12, p. 3483-3492 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Synergistic Combination of Polymyxin B and Enrofloxacin Induced Metabolic Perturbations in Extensive Drug-resistant Pseudomonas aeruginosa

Lin, Y-W., Han, M-L., Zhao, J., Zhu, Y., Rao, G., Forrest, A., Song, J., Kaye, K. S., Hertzog, P., Purcell, A., Creek, D., Zhou, T. Q., Velkov, T. & Li, J., 3 Oct 2019, In : Frontiers in Pharmacology. 10, 11 p., 1146.

Research output: Contribution to journalArticleResearchpeer-review

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Targeting XIAP and PPARγ in granulosa cell tumors alters metabolic signaling

Leung, T. H., Rainczuk, A., Nguyen, T., Stephens, A., Silke, J., Fuller, P. J. & Chu, S., 5 Apr 2019, In : Journal of Proteome Research. 18, 4, p. 1691-1701 11 p.

Research output: Contribution to journalArticleResearchpeer-review

1 Citation (Scopus)

The Single Nucleotide Polymorphism Mal-D96N Mice Provide New Insights into Functionality of Mal in TLR Immune Responses

Dowling, J. K., Tate, M. D., Rosli, S., Bourke, N. M., Bitto, N., Lauterbach, M. A., Cheung, S., Ve, T., Kobe, B., Golenbock, D. & Mansell, A., 15 Apr 2019, In : Journal of Immunology. 202, 8, p. 2384-2396 13 p.

Research output: Contribution to journalArticleResearchpeer-review

2 Citations (Scopus)

The transgenerational effects of oocyte mitochondrial supplementation

St. John, J. C., Makanji, Y., Johnson, J. L., Tsai, T. S., Lagondar, S., Rodda, F., Sun, X., Pangestu, M., Chen, P. & Temple-Smith, P., 1 Dec 2019, In : Scientific Reports. 9, 1, 12 p., 6694.

Research output: Contribution to journalArticleResearchpeer-review

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3 Citations (Scopus)

Toll-like receptor 2 regulates metabolic reprogramming in gastric cancer via superoxide dismutase 2

Liu, Y. D., Yu, L., Ying, L., Balic, J., Gao, H., Deng, N. T., West, A., Yan, F., Ji, C. B., Gough, D., Tan, P., Jenkins, B. J. & Li, J. K., 15 Jun 2019, In : International Journal of Cancer. 144, 12, p. 3056-3069 14 p.

Research output: Contribution to journalArticleResearchpeer-review

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Transfusion or Timing: The Role of Blood Volume in Delayed Cord Clamping During the Cardiovascular Transition at Birth

Stenning, F. J., Hooper, S. B., Kluckow, M., Crossley, K. J., Gill, A. W., Wallace, E. M., te Pas, A. B., LaRosa, D. & Polglase, G. R., 9 Oct 2019, In : Frontiers in Pediatrics. 7, 10 p., 405.

Research output: Contribution to journalArticleResearchpeer-review

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1 Citation (Scopus)

Unique transcriptional architecture in airway epithelial cells and macrophages shapes distinct responses following influenza virus infection Ex vivo

Ma, J. Z., Ng, W. C., Zappia, L., Gearing, L. J., Olshansky, M., Pham, K., Cheong, K., Hsu, A., Turner, S. J., Wijburg, O., Londrigan, S. L., Brooks, A. G. & Reading, P. C., 1 Mar 2019, In : Journal of Virology. 93, 6, 22 p., e01986-18.

Research output: Contribution to journalArticleResearchpeer-review