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2020

Activin A determines steroid levels and composition in the fetal testis

Whiley, P. A. F., O'Donnell, L., Moody, S. C., Handelsman, D. J., Young, J. C., Richards, E. A., Almstrup, K., Western, P. S. & Loveland, K. L., 10 Apr 2020, (Accepted/In press) In : Endocrinology. 41 p.

Research output: Contribution to journalArticleResearchpeer-review

A novel “embryo-endometrial” adhesion model can potentially predict “receptive” or “non-receptive” endometrium

Evans, J., Walker, K. J., Bilandzic, M., Kinnear, S. & Salamonsen, L., Jan 2020, In : Journal of Assisted Reproduction and Genetics. 37, 1, p. 5-16 12 p.

Research output: Contribution to journalArticleResearchpeer-review

1 Citation (Scopus)

Connexin-Dependent Transfer of cGAMP to Phagocytes Modulates Antiviral Responses

Pépin, G., De Nardo, D., Rootes, C. L., Ullah, T. R., Al-Asmari, S. S., Balka, K. R., Li, H-M., Quinn, K. M., Moghaddas, F., Chappaz, S., Kile, B. T., Morand, E. F., Masters, S. L., Stewart, C. R., Williams, B. R. G. & Gantier, M. P., 28 Jan 2020, In : mBio. 11, 1, 6 p., e03187-19.

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1 Citation (Scopus)

Differential tissue-specific damage caused by bacterial epididymo-orchitis in the mouse

Klein, B., Bhushan, S., Gunther, S., Middendorff, R., Loveland, K. L., Hedger, M. P. & Meinhardt, A., 24 Apr 2020, In : Molecular Human Reproduction. 26, 4, p. 215-227 13 p.

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Distinct microbial and immune niches of the human colon

James, K. R., Gomes, T., Elmentaite, R., Kumar, N., Gulliver, E. L., King, H. W., Stares, M. D., Bareham, B. R., Ferdinand, J. R., Petrova, V. N., Polański, K., Forster, S. C., Jarvis, L. B., Suchanek, O., Howlett, S., James, L. K., Jones, J. L., Meyer, K. B., Clatworthy, M. R., Saeb-Parsy, K. & 2 others, Lawley, T. D. & Teichmann, S. A., 1 Mar 2020, In : Nature Immunology. 21, 3, p. 343-353 11 p.

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2 Citations (Scopus)

Diverse effects of interferon alpha on the establishment and reversal of HIV latency

van der Sluis, R. M., Zerbato, J. M., Rhodes, J. W., Pascoe, R. D., Solomon, A., Kumar, N. A., Dantanarayana, A. I., Tennakoon, S., Dufloo, J., McMahon, J., Chang, J. J., Evans, V. A., Hertzog, P. J., Jakobsen, M. R., Harman, A. N., Lewin, S. R. & Cameron, P. U., 1 Jan 2020, In : PLoS Pathogens. 16, 2, 27 p., e1008151.

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Effect of spontaneous breathing on umbilical venous blood flow and during delayed cord clamping in preterm lambs

Brouwer, E., te Pas, A. B., Polglase, G. R., McGillick, E. V., Böhringer, S., Crossley, K. J., Rodgers, K., Blank, D., Yamaoka, S., Gill, A. W., Kluckow, M. & Hooper, S. B., Jan 2020, In : Archives of Disease in Childhood: Fetal and Neonatal Edition. 105, 1, p. F26-F32 7 p.

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2 Citations (Scopus)

Elevated circulating HtrA4 in preeclampsia may alter endothelial expression of senescence genes

Wang, Y., Lim, R. & Nie, G., 15 Jan 2020, In : Placenta. 90, p. 71-81 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Ets-2 deletion in myeloid cells attenuates IL-1α-mediated inflammatory disease caused by a Ptpn6 point mutation

Tartey, S., Gurung, P., Karki, R., Burton, A., Hertzog, P. & Kanneganti, T. D., 19 Mar 2020, (Accepted/In press) In : Cellular & Molecular Immunology. 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Evidence that activin A directly modulates early human male germline differentiation status

Moody, S. C., Wakitani, S., Young, J. C., Western, P. S. & Loveland, K. L., 1 Jul 2020, In : Reproduction. 160, 1, p. 141-154 14 p.

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Induction of left ventricular hypoplasia by occluding the foramen ovale in the fetal lamb

Wong, F. Y., Veldman, A., Sasi, A., Teoh, M., Edwards, A., Chan, Y., Graupner, O., Enzensberger, C., Axt-Fliedner, R., Black, M. J. & Schranz, D., 1 Jan 2020, In : Scientific Reports. 10, 1, 11 p., 880.

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Mutations that prevent caspase cleavage of RIPK1 cause autoinflammatory disease

Lalaoui, N., Boyden, S. E., Oda, H., Wood, G. M., Stone, D. L., Chau, D., Liu, L., Stoffels, M., Kratina, T., Lawlor, K. E., Zaal, K. J. M., Hoffmann, P. M., Etemadi, N., Shield-Artin, K., Biben, C., Tsai, W. L., Blake, M. D., Kuehn, H. S., Yang, D., Anderton, H. & 34 others, Silke, N., Wachsmuth, L., Zheng, L., Moura, N. S., Beck, D. B., Gutierrez-Cruz, G., Ombrello, A. K., Pinto-Patarroyo, G. P., Kueh, A. J., Herold, M. J., Hall, C., Wang, H., Chae, J. J., Dmitrieva, N. I., McKenzie, M., Light, A., Barham, B. K., Jones, A., Romeo, T. M., Zhou, Q., Aksentijevich, I., Mullikin, J. C., Gross, A. J., Shum, A. K., Hawkins, E. D., Masters, S. L., Lenardo, M. J., Boehm, M., Rosenzweig, S. D., Pasparakis, M., Voss, A. K., Gadina, M., Kastner, D. L. & Silke, J., 2 Jan 2020, In : Nature. 577, 7788, p. 103-108 6 p.

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11 Citations (Scopus)

Parsing the IL-37-mediated suppression of inflammasome function

Rudloff, I., Ung, H. K., Dowling, J. K., Mansell, A., D'Andrea, L., Ellisdon, A. M., Whisstock, J., Berger, P., Nold, C. & Nold, M., Jan 2020, In : Cells. 9, 1, 19 p., 178.

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Pre-operative sera interleukin-6 in the diagnosis of high-grade serous ovarian cancer

Kampan, N. C., Madondo, M. T., Reynolds, J., Hallo, J., McNally, O. M., Jobling, T. W., Stephens, A. N., Quinn, M. A. & Plebanski, M., 10 Feb 2020, In : Scientific Reports. 10, 1, 15 p., 2213.

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1 Citation (Scopus)

Prostate cancer cell-intrinsic interferon signaling regulates dormancy and metastatic outgrowth in bone

Owen, K. L., Gearing, L. J., Zanker, D. J., Brockwell, N. K., Khoo, W. H., Roden, D. L., Cmero, M., Mangiola, S., Hong, M. K., Spurling, A. J., McDonald, M., Chan, C. L., Pasam, A., Lyons, R. J., Duivenvoorden, H. M., Ryan, A., Butler, L. M., Mariadason, J. M., Giang Phan, T., Hayes, V. M. & 7 others, Sandhu, S., Swarbrick, A., Corcoran, N. M., Hertzog, P. J., Croucher, P. I., Hovens, C. & Parker, B. S., 4 Jun 2020, In : EMBO Reports. 21, 6, 24 p., e50162.

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1 Citation (Scopus)

Proteomic Insights into Endometrial Receptivity and Embryo-Endometrial Epithelium Interaction for Implantation Reveal Critical Determinants of Fertility

Evans, J., Hutchison, J., Salamonsen, L. A. & Greening, D. W., Jan 2020, In : Proteomics. 20, 1, 13 p., 1900250.

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Ptpn6 inhibits caspase-8- and Ripk3/Mlkl-dependent inflammation

Speir, M., Nowell, C. J., Chen, A. A., O’Donnell, J. A., Shamie, I. S., Lakin, P. R., D’Cruz, A. A., Braun, R. O., Babon, J. J., Lewis, R. S., Bliss-Moreau, M., Shlomovitz, I., Wang, S., Cengia, L. H., Stoica, A. I., Hakem, R., Kelliher, M. A., O’Reilly, L. A., Patsiouras, H., Lawlor, K. E. & 5 others, Weller, E., Lewis, N. E., Roberts, A. W., Gerlic, M. & Croker, B. A., 1 Jan 2020, In : Nature Immunology. 21, 1, p. 54-64 11 p.

Research output: Contribution to journalArticleResearchpeer-review

2 Citations (Scopus)

Sleep macro-architecture and micro-architecture in children born preterm with sleep disordered breathing

Chan, M., Wong, T. C. H., Weichard, A., Nixon, G. M., Walter, L. M. & Horne, R. S. C., Mar 2020, In : Pediatric Research. 87, 4, p. 703-710 8 p.

Research output: Contribution to journalArticleResearchpeer-review

STAT3-driven hematopoiesis and lymphopoiesis abnormalities are dependent on serine phosphorylation

Balic, J. J., White, C. L., Dawson, R., Gough, D., McCormack, M. P. & Jenkins, B. J., Jun 2020, In : Cytokine. 130, 6 p., 155059.

Research output: Contribution to journalArticleResearchpeer-review

TBK1 and IKKε Act Redundantly to Mediate STING-Induced NF-κB Responses in Myeloid Cells

Balka, K. R., Louis, C., Saunders, T. L., Smith, A. M., Calleja, D. J., D'Silva, D. B., Moghaddas, F., Tailler, M., Lawlor, K. E., Zhan, Y., Burns, C. J., Wicks, I. P., Miner, J. J., Kile, B. T., Masters, S. L. & De Nardo, D., 7 Apr 2020, In : Cell Reports. 31, 1, 22 p., 107492.

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‘Snail factors in testicular germ cell tumours and their regulation by the BMP4 signalling pathway’

Micati, D. J., Radhakrishnan, K., Young, J. C., Rajpert-De Meyts, E., Hime, G. R., Abud, H. E. & Loveland, K. L., 22 May 2020, (Accepted/In press) In : Andrology. 15 p.

Research output: Contribution to journalArticleResearchpeer-review

2019

A cell type-specific transcriptomic approach to map B cell and monocyte type I interferon-linked pathogenic signatures in Multiple Sclerosis

Severa, M., Rizzo, F., Srinivasan, S., Di Dario, M., Giacomini, E., Buscarinu, M. C., Cruciani, M., Etna, M. P., Sandini, S., Mechelli, R., Farina, A., Trivedi, P., Hertzog, P. J., Salvetti, M., Farina, C. & Coccia, E. M., 1 Jul 2019, In : Journal of Autoimmunity. 101, p. 1-16 16 p.

Research output: Contribution to journalArticleResearchpeer-review

1 Citation (Scopus)

Activin A target genes are differentially expressed between normal and neoplastic adult human testes: clues to gonocyte fate choice

Szarek, M., Bergmann, M., Konrad, L., Schuppe, H. C., Kliesch, S., Hedger, M. P. & Loveland, K. A. L., 1 Jan 2019, In : Andrology. 7, 1, p. 31-41 11 p.

Research output: Contribution to journalArticleResearchpeer-review

3 Citations (Scopus)

Acute heat-treatment disrupts inhibin-related protein production and gene expression in the adult rat testis

Aldahhan, R. A., Stanton, P., Ludlow, H., de Kretser, D. & Hedger, M., 1 Dec 2019, In : Molecular and Cellular Endocrinology. 498, 12 p., 110546.

Research output: Contribution to journalArticleResearchpeer-review

ADAM17: An emerging therapeutic target for lung cancer

Saad, M. I., Rose-John, S. & Jenkins, B. J., 21 Aug 2019, In : Cancers. 11, 9, 28 p., 1218.

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6 Citations (Scopus)

ADAM17 selectively activates the IL-6 trans-signaling/ERK MAPK axis in KRAS-addicted lung cancer

Saad, M. I., Alhayyani, S., McLeod, L., Yu, L., Alanazi, M., Deswaerte, V., Tang, K., Jarde, T., Smith, J. A., Prodanovic, Z., Tate, M. D., Balic, J. J., Watkins, D. N., Cain, J. E., Bozinovski, S., Algar, E., Kohmoto, T., Ebi, H., Ferlin, W., Garbers, C. & 4 others, Ruwanpura, S., Sagi, I., Rose-John, S. & Jenkins, B. J., Apr 2019, In : EMBO Molecular Medicine. 11, 4, 19 p., e9976.

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7 Citations (Scopus)

Adaptation of host transmission cycle during Clostridium difficile speciation

Kumar, N., Browne, H. P., Viciani, E., Forster, S. C., Clare, S., Harcourt, K., Stares, M. D., Dougan, G., Fairley, D. J., Roberts, P., Pirmohamed, M., Clokie, M. R. J., Jensen, M. B. F., Hargreaves, K. R., Ip, M., Wieler, L. H., Seyboldt, C., Norén, T., Riley, T. V., Kuijper, E. J. & 2 others, Wren, B. W. & Lawley, T. D., 1 Sep 2019, In : Nature Genetics. 51, 9, p. 1315-1320 6 p.

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5 Citations (Scopus)

A human gut bacterial genome and culture collection for improved metagenomic analyses

Forster, S. C., Kumar, N., Anonye, B. O., Almeida, A., Viciani, E., Stares, M. D., Dunn, M., Mkandawire, T. T., Zhu, A., Shao, Y., Pike, L. J., Louie, T., Browne, H. P., Mitchell, A. L., Neville, B. A., Finn, R. D. & Lawley, T. D., 1 Feb 2019, In : Nature Biotechnology. 37, 2, p. 186-192 7 p.

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47 Citations (Scopus)

A new genomic blueprint of the human gut microbiota

Almeida, A., Mitchell, A. L., Boland, M., Forster, S. C., Gloor, G. B., Tarkowska, A., Lawley, T. D. & Finn, R. D., 25 Apr 2019, In : Nature. 568, 7753, p. 499-504 6 p.

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107 Citations (Scopus)

Anti-Helicobacter pylori activity of ethoxzolamide

Modak, J. K., Tikhomirova, A., Gorrell, R. J., Rahman, M. M., Kotsanas, D., Korman, T. M., Garcia-Bustos, J., Kwok, T., Ferrero, R. L., Supuran, C. T. & Roujeinikova, A., 1 Dec 2019, In : Journal of Enzyme Inhibition and Medicinal Chemistry. 34, 1, p. 1660-1667 8 p.

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5 Citations (Scopus)

A structural "star" in interferon gamma signaling

Hertzog, P. J. & de Weerd, N. A., 1 May 2019, In : Immunology and Cell Biology. 97, 5, p. 442-444 3 p.

Research output: Contribution to journalArticleOtherpeer-review

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1 Citation (Scopus)

CiIIder: A tool for predicting and analysing transcription factor binding sites

Gearing, L. J., Cumming, H. E., Chapman, R., Finkel, A. M., Woodhouse, I. B., Luu, K., Gould, J. A., Forster, S. C. & Hertzog, P. J., 4 Sep 2019, In : PLoS ONE. 14, 9, 12 p., e0215495.

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1 Citation (Scopus)

Cisplatin- and cyclophosphamide-induced primordial follicle depletion is caused by direct damage to oocytes

Nguyen, QN., Zerafa, N., Liew, J., Findlay, J. K., Hickey, M. & Hutt, K., 1 Aug 2019, In : Molecular Human Reproduction. 25, 8, p. 433-444 12 p.

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8 Citations (Scopus)

Combined PPARγ Activation and XIAP Inhibition as a Potential Therapeutic Strategy for Ovarian Granulosa Cell Tumors

Leung, D. T. H., Nguyen, T., Oliver, E. M., Matti, J., Alexiadis, M., Silke, J., Jobling, T. W., Fuller, P. J. & Chu, S., 1 Feb 2019, In : Molecular Cancer Therapeutics. 18, 2, p. 364-375 12 p.

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4 Citations (Scopus)

Comparative metabolomics and transcriptomics reveal multiple pathways associated with polymyxin killing in pseudomonas aeruginosa

Han, M-L., Zhu, Y., Creek, D. J., Lin, Y-W., Gutu, A. D., Hertzog, P., Purcell, T., Shen, H-H., Moskowitz, S. M., Velkov, T. & Li, J., 1 Jan 2019, In : mSystems. 4, 1, 18 p., e00149-18.

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7 Citations (Scopus)

Complete genome sequence of Helicobacter pylori B128 7.13 and a single-step method for the generation of unmarked mutations

Dawson, E. M., Dunne, K. A., Richardson, E. J., Praszkier, J., Alfawaz, D., Woelfel, S., De Paoli, A., Chaudhry, H., Henderson, I. R., Ferrero, R. L. & Rossiter, A. E., 1 Aug 2019, In : Helicobacter. 24, 4, 10 p., e12587.

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DDX5 plays essential transcriptional and post-transcriptional roles in the maintenance and function of spermatogonia

Legrand, J. M. D., Chan, A. L., La, H. M., Rossello, F., Anko, M-L., Fuller-Pace, F. V. & Hobbs, R., 1 Dec 2019, In : Nature Communications. 10, 1, 21 p., 2278.

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4 Citations (Scopus)

Deep multi-region whole-genome sequencing reveals heterogeneity and gene-by-environment interactions in treatment-naive, metastatic lung cancer

Leong, T. L., Gayevskiy, V., Steinfort, D. P., De Massy, M. R., Gonzalez-Rajal, A., Marini, K. D., Stone, E., Chin, V., Havryk, A., Plit, M., Irving, L. B., Jennings, B. R., McCloy, R. A., Jayasekara, W. S. N., Alamgeer, M., Boolell, V., Field, A., Russell, P. A., Kumar, B., Gough, D. J. & 8 others, Szczepny, A., Ganju, V., Rossello, F. J., Cain, J. E., Papenfuss, A. T., Asselin-Labat, M. L., Cowley, M. J. & Watkins, D. N., 7 Mar 2019, In : Oncogene. 38, 10, p. 1661-1675 15 p.

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1 Citation (Scopus)

Deleting Suppressor of Cytokine Signaling-3 in chondrocytes reduces bone growth by disrupting mitogen-activated protein kinase signaling

Liu, X., D'Cruz, A. A., Hansen, J., Croker, B. A., Lawlor, K. E., Sims, N. A. & Wicks, I. P., Oct 2019, In : Osteoarthritis and Cartilage. 27, 10, p. 1557-1563 7 p.

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1 Citation (Scopus)

Detection of chlamydia infection within human testicular biopsies

Bryan, E. R., McLachlan, R. I., Rombauts, L., Katz, D. J., Yazdani, A., Bogoevski, K., Chang, C., Giles, M. L., Carey, A. J., Armitage, C. W., Trim, L. K., McLaughlin, E. A. & Beagley, K. W., 2 Oct 2019, In : Human Reproduction. 34, 10, p. 1891-1898 8 p.

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2 Citations (Scopus)

Elevated protease HtrA4 in the maternal circulation of preeclampsia may contribute to endothelial barrier disruption by cleaving key junctional protein VE-cadherin

Tseng, E., Yee Teoh, S. S., Wang, Y. & Nie, G., 15 Jan 2019, In : Placenta. 76, 15, p. 51-53 3 p.

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Fetal growth restriction alters cerebellar development in fetal and neonatal sheep

Yawno, T., Sutherland, A. E., Pham, Y., Castillo-Melendez, M., Jenkin, G. & Miller, S., 22 May 2019, In : Frontiers in Physiology. 10, MAY, 12 p., 560.

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1 Citation (Scopus)

High levels of HtrA4 detected in preeclamptic circulation may disrupt endothelial cell function by cleaving the main VEGFA receptor KDR

Wang, Y., La, M., Pham, T., Lovrecz, G. O. & Nie, G., 1 Apr 2019, In : The FASEB Journal. 33, 4, p. 5058-5066 9 p.

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4 Citations (Scopus)

HtrA4 may play a major role in inhibiting endothelial repair in pregnancy complication preeclampsia

Wang, Y., Lim, R. & Nie, G., 1 Dec 2019, In : Scientific Reports. 9, 1, 14 p., 2728.

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1 Citation (Scopus)

Human Endometrial Extracellular Vesicles Functionally Prepare Human Trophectoderm Model for Implantation: Understanding Bidirectional Maternal-Embryo Communication

Evans, J., Rai, A., Nguyen, H. P. T., Poh, Q. H., Elglass, K., Simpson, R. J., Salamonsen, L. & Greening, D. W., 1 Dec 2019, In : Proteomics. 19, 23, 17 p., 1800423.

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4 Citations (Scopus)

Interleukin 1 Up-regulates MicroRNA 135b to Promote Inflammation-Associated Gastric Carcinogenesis in Mice

Han, T. S., Voon, D. C. C., Oshima, H., Nakayama, M., Echizen, K., Sakai, E., Yong, Z. W. E., Murakami, K., Yu, L., Minamoto, T., Ock, C. Y., Jenkins, B. J., Kim, S. J., Yang, H. K. & Oshima, M., 1 Mar 2019, In : Gastroenterology. 156, 4, p. 1140-1155.e4 20 p.

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13 Citations (Scopus)

Interplay between Follistatin, Activin A, and BMP4 Signaling Regulates Postnatal Thymic Epithelial Progenitor Cell Differentiation during Aging

Lepletier, A., Hun, M. L., Hammett, M. V., Wong, K., Naeem, H., Hedger, M., Loveland, K. & Chidgey, A. P., 25 Jun 2019, In : Cell Reports. 27, 13, p. 3887–3901–e4 19 p.

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5 Citations (Scopus)

Investigation of activin A in inflammatory responses of the testis and its role in the development of testicular fibrosis

Kauerhof, A. C., Nicolas, N., Bhushan, S., Wahle, E., Loveland, K. A., Fietz, D., Bergmann, M., Groome, N. P., Kliesch, S., Schuppe, H-C., Pilatz, A., Meinhardt, A., Hedger, M. P. & Fijak, M., 1 Aug 2019, In : Human Reproduction. 34, 8, p. 1536-1550 15 p.

Research output: Contribution to journalArticleResearchpeer-review

Lnc(ing) interferon production and action

Sen, G. C. & Williams, B. R. G., 1 Sep 2019, In : Cell Research. 29, 9, p. 690-691 2 p.

Research output: Contribution to journalArticleOtherpeer-review

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