Hudson Institute - Department of Molecular and Translational Science

Research Output

2016
9 Citations (Scopus)

Therapeutic targeting of the IL-6 trans-signaling/mechanistic target of rapamycin complex 1 axis in pulmonary emphysema

Ruwanpura, S. M., McLeod, L., Dousha, L. F., Seow, H. J., Alhayyani, S., Tate, M. D., Deswaerte, V., Brooks, G. D., Bozinovski, S., MacDonald, M., Garbers, C., King, P. T., Bardin, P. G., Vlahos, R., Rose-John, S., Anderson, G. P. & Jenkins, B. J., 15 Dec 2016, In : American Journal of Respiratory and Critical Care Medicine. 194, 12, p. 1494-1505 12 p.

Research output: Contribution to journalArticleResearchpeer-review

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22 Citations (Scopus)

The relationship between mitochondrial DNA haplotype and the reproductive capacity of domestic pigs (Sus scrofa domesticus)

Tsai, T-S., Rajasekar, S. & St. John, J. C., 18 May 2016, In : BMC Genetics. 17, 1, 17 p., 67.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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20 Citations (Scopus)

The role of CX3CL1 in fetal-maternal interaction during human gestation

Kervancioglu Demirci, E., Salamonsen, L. A. & Gauster, M., 3 Mar 2016, In : Cell Adhesion and Migration. 10, 1-2, p. 189-196 8 p.

Research output: Contribution to journalReview ArticleOtherpeer-review

8 Citations (Scopus)

The role of mitochondria and mitochondrial DNA in fertilisation and development outcome

St John, J. C. & Tsai, T-S., 24 Oct 2016, IVF Worldwide: Virtual Academy of Egg Health. IVF Worldwide

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Other

The role of mitochondrial DNA copy number, variants, and haplotypes in farm animal developmental outcome

Tsai, T. & St. John, J. C., Jul 2016, In : Domestic Animal Endocrinology. 56, p. S133-S146 14 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

9 Citations (Scopus)

The role of the mtDNA set point in differentiation, development and tumorigenesis

Sun, X. & St. John, J. C., 27 Sep 2016, In : Biochemical Journal. 473, 19, p. 2955-2971 17 p.

Research output: Contribution to journalReview ArticleOtherpeer-review

13 Citations (Scopus)

The SMAC mimetic, LCL-161, reduces survival in aggressive MYC-driven lymphoma while promoting susceptibility to endotoxic shock

West, A. C., Martin, B. P., Andrews, D. A., Hogg, S. J., Banerjee, A., Grigoriadis, G., Johnstone, R. W. & Shortt, J., 4 Apr 2016, In : Oncogenesis. 5, 6 p., e216.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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13 Citations (Scopus)

The TGF-β signalling network in muscle development, adaptation and disease

Chen, J. L., Colgan, T. D., Walton, K. L., Gregorevic, P. & Harrison, C. A., 1 May 2016, Advances in Experimental Medicine and Biology. Springer, Vol. 900. p. 97-131 35 p. (Advances in Experimental Medicine and Biology; vol. 900).

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Otherpeer-review

21 Citations (Scopus)

The use of malaria glycosaminoglycan to block cancers-lessons from the human placenta

Dimitriadis, E., 2016, In : Translational Cancer Research. 5, p. S1085-S1087 3 p.

Research output: Contribution to journalEditorialOtherpeer-review

1 Citation (Scopus)

The Vaccine Adjuvant Chitosan Promotes Cellular Immunity via DNA Sensor cGAS-STING-Dependent Induction of Type I Interferons

Carroll, E. C., Jin, L., Mori, A., Muñoz-Wolf, N., Oleszycka, E., Moran, H. B. T., Mansouri, S., McEntee, C. P., Lambe, E. M., Agger, E. M., Andersen, P., Cunningham, C., Hertzog, P., Fitzgerald, K. A., Bowie, A. G. & Lavelle, E. C., 15 Mar 2016, In : Immunity. 44, 3, p. 597-608 12 p.

Research output: Contribution to journalArticleResearchpeer-review

161 Citations (Scopus)

Tissue response to collagen containing polypropylene meshes in an ovine vaginal repair model

Darzi, S., Urbankova, I., Su, K., White, J., Lo, C., Alexander, D. M., Werkmeister, J. A., Gargett, C. E. & Deprest, J., 15 Jul 2016, In : Acta Biomaterialia. 39, p. 114-123 10 p.

Research output: Contribution to journalArticleResearchpeer-review

21 Citations (Scopus)

Tob1 is expressed in developing and adult gonads and is associated with the P-body marker, Dcp2

Shapouri, F., Saeidi, S., de Iongh, R. U., Casagranda, F., Western, P. S., McLaughlin, E. A., Sutherland, J. M., Hime, G. R. & Familari, M., 1 May 2016, In : Cell and Tissue Research. 364, 2, p. 443-451 9 p.

Research output: Contribution to journalArticleResearchpeer-review

6 Citations (Scopus)

Toll-IL1 receptor-mediated innate immune responses vary across HBV genotype and predict treatment response to pegylated-IFN in HBeAg-positive CHB patients

Visvanathan, K., Lang, T., Ryan, K., Wilson, R., Skinner, N. A., Thompson, A. J. V., Ahn, S. H., Weilert, F., Abbott, W., Gane, E., Colledge, D., Li, K., Locarnini, S., Mansell, A. & Revill, P. A., 1 Mar 2016, In : Journal of Viral Hepatitis. 23, 3, p. 170-179 10 p.

Research output: Contribution to journalArticleResearchpeer-review

6 Citations (Scopus)

Toll-like receptors: Ligands, cell-based models, and readouts for receptor action

Dowling, J. K. & Dellacasagrande, J., 1 Jan 2016, Toll-Like Receptors: Practice and Methods. McCoy, C. E. (ed.). 2nd ed. New York USA: Humana Press, Vol. 1390. p. 3-27 25 p. (Methods in Molecular Biology; vol. 1390).

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Otherpeer-review

11 Citations (Scopus)

Toll-like receptors: the swiss army knife of immunity and vaccine development

Dowling, J. K. & Mansell, A., 2016, In : Clinical & Translational Immunology. 5, 10 p., e85.

Research output: Contribution to journalReview ArticleResearchpeer-review

Open Access
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Total PC activity is increased in uterine lavage of post-menopausal endometrial but not ovarian cancer patients

Heng, S., Stephens, A. N., Jobling, T. W. & Nie, G-Y., 2016, In : Journal of Cancer. 7, 13, p. 1812 - 1814 3 p.

Research output: Contribution to journalArticleOtherpeer-review

2 Citations (Scopus)

Transcriptomic analysis of stage 1 versus advanced adult granulosa cell tumors

Alexiadis, M., Chu, S., Leung, D., Gould, J. A., Jobling, T. & Fuller, P. J., 2016, In : Oncotarget. 7, 12, p. 14207 - 14219 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
9 Citations (Scopus)

Transcytosis of IL-11 and Apical Redirection of gp130 Is Mediated by IL-11α Receptor

Monhasery, N., Moll, J., Cuman, C., Franke, M., Lamertz, L., Nitz, R., Görg, B., Häussinger, D., Lokau, J., Floss, D. M., Piekorz, R., Dimitriadis, E., Garbers, C. & Scheller, J., 26 Jul 2016, In : Cell Reports. 16, 4, p. 1067-1081 15 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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12 Citations (Scopus)

Transition to Palliative Care for Patients with Metastatic Prostate Cancer: How Well Have We Integrated?

Collins, A., Burchell, J., Sundararajan, V., Millar, J. L., Le, B., Currow, D., Hudson, P., McLachlan, S-A., Mileshkin, L. & Krishnasamy, M., 1 Dec 2016, p. e150-e151. 2 p.

Research output: Contribution to conferenceAbstract

Translocation and dissemination of commensal bacteria in post-stroke infection

Stanley, D., Mason, L. J., MacKin, K. E., Srikhanta, Y. N., Lyras, D., Prakash, M. D., Nurgali, K., Venegas, A., Hill, M. D., Moore, R. J. & Wong, C. H. Y., 1 Nov 2016, In : Nature Medicine. 22, 11, p. 1277-1284 8 p.

Research output: Contribution to journalArticleResearchpeer-review

70 Citations (Scopus)

TRIF-dependent TLR signaling, its functions in host defense and inflammation, and its potential as a therapeutic target

Ullah, M. O., Sweet, M. J., Mansell, A., Kellie, S. & Kobe, B., 1 Jul 2016, In : Journal of leukocyte biology. 100, 1, p. 27-45 19 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

38 Citations (Scopus)

Urogenital development in Pallister-Hall syndrome is disrupted in a cell-lineage-specific manner by constitutive expression of GLI3 repressor

Blake, J., Hu, D., Cain, J. E. & Rosenblum, N. D., 1 Feb 2016, In : Human Molecular Genetics. 25, 3, p. 437-447 11 p., ddv483.

Research output: Contribution to journalArticleResearchpeer-review

8 Citations (Scopus)

Uropathogenic Escherichia coli causes fibrotic remodelling of the epididymis

Michel, V., Duan, Y., Stoschek, E., Bhushan, S., Middendorff, R., Young, J. M., Loveland, K. L., Kretser, D. M. D., Hedger, M. P. & Meinhardt, A., 1 Sep 2016, In : Journal of Pathology. 240, 1, p. 15-24 10 p.

Research output: Contribution to journalArticleResearchpeer-review

15 Citations (Scopus)

Virulence mechanisms of helicobacter pylori: An overview

Praszkier, J., Sutton, P. & Ferrero, R. L., 1 Jan 2016, Helicobacter pylori Research: From Bench to Bedside. Backert, S. & Yamaoka, Y. (eds.). Springer, p. 57-87 31 p.

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Otherpeer-review

2 Citations (Scopus)

WNT/β-catenin and p27/FOXL2 differentially regulate supporting cell proliferation in the developing ovary

Gustin, S. E., Hogg, K., Stringer, J. M., Rastetter, R. H., Pelosi, E., Miles, D. C., Sinclair, A. H., Wilhelm, D. & Western, P. S., 15 Apr 2016, In : Developmental Biology. 412, 2, p. 250-260 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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17 Citations (Scopus)
2015

A comparison of high-frequency jet ventilation and synchronised intermittent mandatory ventilation in preterm lambs

Musk, G. C., Polglase, G., Bunnell, J. B., Nitsos, I., Tingay, D. G. & Pillow, J., 2015, In : Pediatric Pulmonology. 50, 12, p. 1286 - 1293 8 p.

Research output: Contribution to journalArticleResearchpeer-review

4 Citations (Scopus)

A critical role of Oct4A in mediating metastasis and disease-free survival in a mouse model of ovarian cancer

Samardzija, C., Luwor, R. B., Volchek, M., Quinn, M. A., Findlay, J. J. K. & Ahmed, N., 2015, In : Molecular Cancer. 14, p. 1 - 19 19 p., 152.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
17 Citations (Scopus)

Activation of the kynurenine pathway and increased production of the excitotoxin quinolinic acid following traumatic brain injury in humans

Yan, E. B., Frugier, T. J., Lim, C. K., Heng, B., Sundaram, G., Tan, M., Rosenfeld, J. V., Walker, D. W., Guillemin, G. J. & Morganti-Kossmann, M. C., 12 Dec 2015, In : Journal of Neuroinflammation. 12, 1, 17 p., 110.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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34 Citations (Scopus)

Activin A contributes to the development of hyperoxia-induced lung injury in neonatal mice

Lim, R. S. W., Muljadi, R. C. M., Koulaeva, E., Vosdoganes, P., Chan, S. T., Acharya, R., Gurusinghe, S., Ritvos, O., Pasternack, A. & Wallace, E. M., 2015, In : Pediatric Research. 77, 6, p. 749 - 756 8 p.

Research output: Contribution to journalArticleResearchpeer-review

8 Citations (Scopus)

Activin and NADPH-oxidase in preeclampsia: insights from in vitro and murine studies

Lim, R., Acharya, R., Delpachitra, P., Hobson, S., Sobey, C. G., Drummond, G. R. & Wallace, E. M., 1 Jan 2015, In : American Journal of Obstetrics and Gynecology. 212, 1, p. 86.e1 - 86.e12 12 p.

Research output: Contribution to journalArticleResearchpeer-review

35 Citations (Scopus)

Activins and inhibins in Sertoli cell biology: implications for testis development and function

Loveland, K. L. & Hedger, M. P., 2015, Sertoli Cell Biology. Griswold, M. D. (ed.). 2nd ed. Amsterdam The Netherlands: Elsevier, p. 201-232 32 p.

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Researchpeer-review

ADAM12-directed ectodomain shedding of E-cadherin potentiates trophoblast fusion

Aghababaei, M., Hogg, K., Persu, S., Robinson, W. P. & Beristain, A. G., 2015, In : Cell Death and Differentiation. 22, 12, p. 1970 - 1984 15 p.

Research output: Contribution to journalArticleResearchpeer-review

15 Citations (Scopus)

Adult Sertoli cell differentiation status in humans

Haverfield, J. T., Stanton, P. G. & Meachem, S. J., 2015, Sertoli Cell Biology. Griswold, M. D. (ed.). 2nd ed. Amsterdam The Netherlands: Elsevier, p. 409-436 28 p.

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Researchpeer-review

Aldosterone-mediated renal sodium transport requires intact mineralocorticoid receptor DNA binding in the mouse

Cole, T. J., Terella, L. R., Morgan, J., Alexiadis, M., Yao, Y-Z., Enriori, P., Young, M. J. & Fuller, P. J., 2015, In : Endocrinology. 156, 8, p. 2958 - 2968 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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4 Citations (Scopus)

Allopregnanolone and social stress: regulation of the stress response in early pregnancy in pigs

Rault, J-L., Plush, K., Yawno, T. & Langendijk, P., 2015, In : Stress-The International Journal on the Biology of Stress. 18, 5, p. 569 - 577 9 p.

Research output: Contribution to journalArticleResearchpeer-review

1 Citation (Scopus)

Alphaxalone reformulated: a water-soluble intravenous anesthetic preparation in sulfobutyl-ether-(beta)-cyclodextrin

Goodchild, C. S., Serrao, J. M., Kolosov, A. & Boyd, B. J., 2015, In : Anesthesia and Analgesia. 120, 5, p. 1025 - 1031 7 p.

Research output: Contribution to journalArticleResearchpeer-review

24 Citations (Scopus)

A meta-analysis of somatic KCNJ5 K(+) channel mutations in 1636 patients with an aldosterone-producing adenoma

Lenzini, L., Rossitto, G., Maiolino, G., Letizia, C., Funder, J. W. & Rossi, G. P., 2015, In : The Journal of Clinical Endocrinology and Metabolism. 100, 8, p. 1089 - 1095 7 p.

Research output: Contribution to journalArticleResearchpeer-review

87 Citations (Scopus)

Amnion cell-mediated immune modulation following bleomycin challenge: controlling the regulatory T cell response

Tan, J., Chan, S. T., Lo, C. Y-W., Deane, J. A., McDonald, C., Bernard, C. C. A., Wallace, E. M. & Lim, R. S. W., 2015, In : Stem Cell Research and Therapy. 6, 1, p. 1 - 12 12 p., 8.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
31 Citations (Scopus)

Analysis of ER-mitochondria contacts using correlative fluorescence microscopy and soft X-ray tomography of mammalian cells

Elgass, K., Smith, E. A., LeGros, M. A., Larabell, C. A. & Ryan, M. T., 2015, In : Journal of Cell Science. 128, 15, p. 2795 - 2804 10 p.

Research output: Contribution to journalArticleResearchpeer-review

40 Citations (Scopus)

Analysis of mitochondrial DNA in induced pluripotent and embryonic stem cells

Lee, W., Kelly, R. D. W., Yeung, K. Y. V., Cagnone, G., McKenzie, M. & St John, J. C., 2015, Cell Reprogramming : Methods and Protocols. Verma, P. J. & Sumer, H. (eds.). 1st ed. Totowa NJ USA: Humana Press, p. 219 - 252 34 p. (Methods in Molecular Biology).

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Otherpeer-review

2 Citations (Scopus)

An authentic animal model of the very preterm infant on nasal continuous positive airway pressure

Dargaville, P. A., Lavizzari, A., Padoin, P., Black, D., Zonneveld, E., Perkins, E., Sourial, M., Rajapaksa, A. E., Davis, P. G., Hooper, S. B., Moss, T. J. M., Polglase, G. & Tingay, D. G., 2015, In : Intensive Care Medicine Experimental. 3, 12 p., 13.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Anti-cancer analogues ME-143 and ME-344 exert toxicity by directly inhibiting mitochondrial NADH: Ubiquinone oxidoreductase (Complex I)

Lim, S. C., Carey, K. T. & McKenzie, M., 2015, In : American Journal of Cancer Research. 5, 2, p. 689-701 13 p.

Research output: Contribution to journalArticleResearchpeer-review

22 Citations (Scopus)

A percutaneous fetal cardiac catheterization technique for pulmonary valvuloplasty and valvulotomy in a mid-gestation lamb model

Edwards, A., Veldman, A., Nitsos, I., Chan, Y., Brew, N., Teoh, M., Menahem, S., Schranz, D. & Wong, F. Y-W., 2015, In : Prenatal Diagnosis. 35, 1, p. 74 - 80 7 p.

Research output: Contribution to journalArticleResearchpeer-review

7 Citations (Scopus)

Apert syndrome: temporal lobe abnormalities on fetal brain imaging

Stark, Z., McGillivray, G., Sampson, A. K., Palma-Dias, R., Edwards, A., Said, J. M., Whiteley, G. & Fink, A. M., 2015, In : Prenatal Diagnosis. 35, 2, p. 179 - 182 4 p.

Research output: Contribution to journalArticleResearchpeer-review

11 Citations (Scopus)

A phase 1c trial comparing the efficacy and safety of a new aqueous formulation of alphaxalone with propofol

Monagle, J., Siu, W. L., Worrell, J., Goodchild, C. S. & Serrao, J. M., 2015, In : Anesthesia and Analgesia. 121, 4, p. 914 - 924 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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23 Citations (Scopus)

A randomised crossover trial of clinical algorithm for oxygen saturation targeting in preterm infants with frequent desaturation episodes

Clarke, A., Yeomans, E., Elsayed, K., Medhurst, A., Berger, P. J., Skuza, E. M. & Tan, K. H. H., 2015, In : Neonatology. 107, 2, p. 130 - 136 7 p.

Research output: Contribution to journalArticleResearchpeer-review

14 Citations (Scopus)

A review of current animal models for the study of cervical dysplasia and cervical carcinoma

Larmour, L. I., Jobling, T. W. & Gargett, C. E., 1 Oct 2015, In : International Journal of Gynecological Cancer. 25, 8, p. 1345-1352 8 p.

Research output: Contribution to journalArticleResearchpeer-review

10 Citations (Scopus)

Aromatase overexpression in dysfunctional adipose tissue links obesity to postmenopausal breast cancer

Wang, X., Simpson, E. R. & Brown, K. A., 2015, In : Journal of Steroid Biochemistry and Molecular Biology. 153, p. 35 - 44 10 p.

Research output: Contribution to journalArticleResearchpeer-review

42 Citations (Scopus)

Assessing the tongue colour of newly born infants may help to predict the need for supplemental oxygen in the delivery room

Dawson, J. A., Ekstrom, A., Frisk, C., Thio, M., Roehr, C. C., Kamlin, C. O. F., Donath, S. & Davis, P. G., 2015, In : Acta Paediatrica. 104, 4, p. 356 - 359 4 p.

Research output: Contribution to journalArticleResearchpeer-review

6 Citations (Scopus)