Hudson Institute - Department of Molecular and Translational Science

Research Output

2019

Tumor inherent interferon regulators as biomarkers of long-term chemotherapeutic response in TNBC

Brockwell, N. K., Rautela, J., Owen, K. L., Gearing, L. J., Deb, S., Harvey, K., Spurling, A., Zanker, D., Chan, C. L., Cumming, H. E., Deng, N., Zakhour, J. M., Duivenvoorden, H. M., Robinson, T., Harris, M., White, M., Fox, J., Ooi, C., Kumar, B., Thomson, J. & 7 others, Potasz, N., Swarbrick, A., Hertzog, P., Molloy, T. J., O’Toole, S., Ganju, V. & Parker, B. S., 29 Aug 2019, In : npj Precision Oncology. 3, 13 p., 21.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Unique transcriptional architecture in airway epithelial cells and macrophages shapes distinct responses following influenza virus infection Ex vivo

Ma, J. Z., Ng, W. C., Zappia, L., Gearing, L. J., Olshansky, M., Pham, K., Cheong, K., Hsu, A., Turner, S. J., Wijburg, O., Londrigan, S. L., Brooks, A. G. & Reading, P. C., 1 Mar 2019, In : Journal of Virology. 93, 6, 22 p., e01986-18.

Research output: Contribution to journalArticleResearchpeer-review

4 Citations (Scopus)

Uterine SOX17: a key player in human endometrial receptivity and embryo implantation

Kinnear, S., Salamonsen, L. A., Francois, M., Harley, V. R. & Evans, J., 29 Oct 2019, In : Scientific Reports. 9, 1, 10 p., 15495.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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2020

Activin A determines steroid levels and composition in the fetal testis

Whiley, P. A. F., O'Donnell, L., Moody, S. C., Handelsman, D. J., Young, J. C., Richards, E. A., Almstrup, K., Western, P. S. & Loveland, K. L., 10 Apr 2020, (Accepted/In press) In : Endocrinology. 41 p.

Research output: Contribution to journalArticleResearchpeer-review

A novel “embryo-endometrial” adhesion model can potentially predict “receptive” or “non-receptive” endometrium

Evans, J., Walker, K. J., Bilandzic, M., Kinnear, S. & Salamonsen, L., Jan 2020, In : Journal of Assisted Reproduction and Genetics. 37, 1, p. 5-16 12 p.

Research output: Contribution to journalArticleResearchpeer-review

1 Citation (Scopus)

Connexin-Dependent Transfer of cGAMP to Phagocytes Modulates Antiviral Responses

Pépin, G., De Nardo, D., Rootes, C. L., Ullah, T. R., Al-Asmari, S. S., Balka, K. R., Li, H-M., Quinn, K. M., Moghaddas, F., Chappaz, S., Kile, B. T., Morand, E. F., Masters, S. L., Stewart, C. R., Williams, B. R. G. & Gantier, M. P., 28 Jan 2020, In : mBio. 11, 1, 6 p., e03187-19.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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1 Citation (Scopus)

Differential tissue-specific damage caused by bacterial epididymo-orchitis in the mouse

Klein, B., Bhushan, S., Gunther, S., Middendorff, R., Loveland, K. L., Hedger, M. P. & Meinhardt, A., 24 Apr 2020, In : Molecular Human Reproduction. 26, 4, p. 215-227 13 p.

Research output: Contribution to journalArticleResearchpeer-review

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Distinct microbial and immune niches of the human colon

James, K. R., Gomes, T., Elmentaite, R., Kumar, N., Gulliver, E. L., King, H. W., Stares, M. D., Bareham, B. R., Ferdinand, J. R., Petrova, V. N., Polański, K., Forster, S. C., Jarvis, L. B., Suchanek, O., Howlett, S., James, L. K., Jones, J. L., Meyer, K. B., Clatworthy, M. R., Saeb-Parsy, K. & 2 others, Lawley, T. D. & Teichmann, S. A., 1 Mar 2020, In : Nature Immunology. 21, 3, p. 343-353 11 p.

Research output: Contribution to journalArticleResearchpeer-review

2 Citations (Scopus)

Diverse effects of interferon alpha on the establishment and reversal of HIV latency

van der Sluis, R. M., Zerbato, J. M., Rhodes, J. W., Pascoe, R. D., Solomon, A., Kumar, N. A., Dantanarayana, A. I., Tennakoon, S., Dufloo, J., McMahon, J., Chang, J. J., Evans, V. A., Hertzog, P. J., Jakobsen, M. R., Harman, A. N., Lewin, S. R. & Cameron, P. U., 1 Jan 2020, In : PLoS Pathogens. 16, 2, 27 p., e1008151.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Editorial: Immunomodulation of innate immune cells

Almeida, C. R., Bottazzi, B., De Nardo, D. & Lawlor, K. E., 11 Feb 2020, In : Frontiers in Immunology. 3 p., 101.

Research output: Contribution to journalEditorialOtherpeer-review

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Effect of spontaneous breathing on umbilical venous blood flow and during delayed cord clamping in preterm lambs

Brouwer, E., te Pas, A. B., Polglase, G. R., McGillick, E. V., Böhringer, S., Crossley, K. J., Rodgers, K., Blank, D., Yamaoka, S., Gill, A. W., Kluckow, M. & Hooper, S. B., Jan 2020, In : Archives of Disease in Childhood: Fetal and Neonatal Edition. 105, 1, p. F26-F32 7 p.

Research output: Contribution to journalArticleResearchpeer-review

2 Citations (Scopus)

Elevated circulating HtrA4 in preeclampsia may alter endothelial expression of senescence genes

Wang, Y., Lim, R. & Nie, G., 15 Jan 2020, In : Placenta. 90, p. 71-81 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Ets-2 deletion in myeloid cells attenuates IL-1α-mediated inflammatory disease caused by a Ptpn6 point mutation

Tartey, S., Gurung, P., Karki, R., Burton, A., Hertzog, P. & Kanneganti, T. D., 19 Mar 2020, (Accepted/In press) In : Cellular & Molecular Immunology. 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Evidence that activin A directly modulates early human male germline differentiation status

Moody, S. C., Wakitani, S., Young, J. C., Western, P. S. & Loveland, K. L., 1 Jul 2020, In : Reproduction. 160, 1, p. 141-154 14 p.

Research output: Contribution to journalArticleResearchpeer-review

From parts lists to functional significance—RNA–protein interactions in gene regulation

Kilchert, C., Sträßer, K., Kunetsky, V. & Änkö, M-L., May 2020, In : Wiley Interdisciplinary Reviews: RNA. 11, 3, 20 p., e1582.

Research output: Contribution to journalReview ArticleResearchpeer-review

1 Citation (Scopus)

Induction of left ventricular hypoplasia by occluding the foramen ovale in the fetal lamb

Wong, F. Y., Veldman, A., Sasi, A., Teoh, M., Edwards, A., Chan, Y., Graupner, O., Enzensberger, C., Axt-Fliedner, R., Black, M. J. & Schranz, D., 1 Jan 2020, In : Scientific Reports. 10, 1, 11 p., 880.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Mutations that prevent caspase cleavage of RIPK1 cause autoinflammatory disease

Lalaoui, N., Boyden, S. E., Oda, H., Wood, G. M., Stone, D. L., Chau, D., Liu, L., Stoffels, M., Kratina, T., Lawlor, K. E., Zaal, K. J. M., Hoffmann, P. M., Etemadi, N., Shield-Artin, K., Biben, C., Tsai, W. L., Blake, M. D., Kuehn, H. S., Yang, D., Anderton, H. & 34 others, Silke, N., Wachsmuth, L., Zheng, L., Moura, N. S., Beck, D. B., Gutierrez-Cruz, G., Ombrello, A. K., Pinto-Patarroyo, G. P., Kueh, A. J., Herold, M. J., Hall, C., Wang, H., Chae, J. J., Dmitrieva, N. I., McKenzie, M., Light, A., Barham, B. K., Jones, A., Romeo, T. M., Zhou, Q., Aksentijevich, I., Mullikin, J. C., Gross, A. J., Shum, A. K., Hawkins, E. D., Masters, S. L., Lenardo, M. J., Boehm, M., Rosenzweig, S. D., Pasparakis, M., Voss, A. K., Gadina, M., Kastner, D. L. & Silke, J., 2 Jan 2020, In : Nature. 577, 7788, p. 103-108 6 p.

Research output: Contribution to journalArticleResearchpeer-review

11 Citations (Scopus)

Parsing the IL-37-mediated suppression of inflammasome function

Rudloff, I., Ung, H. K., Dowling, J. K., Mansell, A., D'Andrea, L., Ellisdon, A. M., Whisstock, J., Berger, P., Nold, C. & Nold, M., Jan 2020, In : Cells. 9, 1, 19 p., 178.

Research output: Contribution to journalArticleResearchpeer-review

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Pre-operative sera interleukin-6 in the diagnosis of high-grade serous ovarian cancer

Kampan, N. C., Madondo, M. T., Reynolds, J., Hallo, J., McNally, O. M., Jobling, T. W., Stephens, A. N., Quinn, M. A. & Plebanski, M., 10 Feb 2020, In : Scientific Reports. 10, 1, 15 p., 2213.

Research output: Contribution to journalArticleResearchpeer-review

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1 Citation (Scopus)

Prostate cancer cell-intrinsic interferon signaling regulates dormancy and metastatic outgrowth in bone

Owen, K. L., Gearing, L. J., Zanker, D. J., Brockwell, N. K., Khoo, W. H., Roden, D. L., Cmero, M., Mangiola, S., Hong, M. K., Spurling, A. J., McDonald, M., Chan, C. L., Pasam, A., Lyons, R. J., Duivenvoorden, H. M., Ryan, A., Butler, L. M., Mariadason, J. M., Giang Phan, T., Hayes, V. M. & 7 others, Sandhu, S., Swarbrick, A., Corcoran, N. M., Hertzog, P. J., Croucher, P. I., Hovens, C. & Parker, B. S., 4 Jun 2020, In : EMBO Reports. 21, 6, 24 p., e50162.

Research output: Contribution to journalArticleResearchpeer-review

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1 Citation (Scopus)

Proteomic Insights into Endometrial Receptivity and Embryo-Endometrial Epithelium Interaction for Implantation Reveal Critical Determinants of Fertility

Evans, J., Hutchison, J., Salamonsen, L. A. & Greening, D. W., Jan 2020, In : Proteomics. 20, 1, 13 p., 1900250.

Research output: Contribution to journalArticleResearchpeer-review

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Ptpn6 inhibits caspase-8- and Ripk3/Mlkl-dependent inflammation

Speir, M., Nowell, C. J., Chen, A. A., O’Donnell, J. A., Shamie, I. S., Lakin, P. R., D’Cruz, A. A., Braun, R. O., Babon, J. J., Lewis, R. S., Bliss-Moreau, M., Shlomovitz, I., Wang, S., Cengia, L. H., Stoica, A. I., Hakem, R., Kelliher, M. A., O’Reilly, L. A., Patsiouras, H., Lawlor, K. E. & 5 others, Weller, E., Lewis, N. E., Roberts, A. W., Gerlic, M. & Croker, B. A., 1 Jan 2020, In : Nature Immunology. 21, 1, p. 54-64 11 p.

Research output: Contribution to journalArticleResearchpeer-review

2 Citations (Scopus)

Sleep macro-architecture and micro-architecture in children born preterm with sleep disordered breathing

Chan, M., Wong, T. C. H., Weichard, A., Nixon, G. M., Walter, L. M. & Horne, R. S. C., Mar 2020, In : Pediatric Research. 87, 4, p. 703-710 8 p.

Research output: Contribution to journalArticleResearchpeer-review

STAT3-driven hematopoiesis and lymphopoiesis abnormalities are dependent on serine phosphorylation

Balic, J. J., White, C. L., Dawson, R., Gough, D., McCormack, M. P. & Jenkins, B. J., Jun 2020, In : Cytokine. 130, 6 p., 155059.

Research output: Contribution to journalArticleResearchpeer-review

TBK1 and IKKε Act Redundantly to Mediate STING-Induced NF-κB Responses in Myeloid Cells

Balka, K. R., Louis, C., Saunders, T. L., Smith, A. M., Calleja, D. J., D'Silva, D. B., Moghaddas, F., Tailler, M., Lawlor, K. E., Zhan, Y., Burns, C. J., Wicks, I. P., Miner, J. J., Kile, B. T., Masters, S. L. & De Nardo, D., 7 Apr 2020, In : Cell Reports. 31, 1, 22 p., 107492.

Research output: Contribution to journalArticleResearchpeer-review

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‘Snail factors in testicular germ cell tumours and their regulation by the BMP4 signalling pathway’

Micati, D. J., Radhakrishnan, K., Young, J. C., Rajpert-De Meyts, E., Hime, G. R., Abud, H. E. & Loveland, K. L., 22 May 2020, (Accepted/In press) In : Andrology. 15 p.

Research output: Contribution to journalArticleResearchpeer-review