Hudson Institute - Department of Molecular and Translational Science

Research Output

2019

Flipping the dogma - Phosphatidylserine in non-apoptotic cell death

Shlomovitz, I., Speir, M. & Gerlic, M., 29 Oct 2019, In : Cell Communication and Signaling. 17, 1, 12 p., 139.

Research output: Contribution to journalReview ArticleResearchpeer-review

Open Access
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4 Citations (Scopus)

High levels of HtrA4 detected in preeclamptic circulation may disrupt endothelial cell function by cleaving the main VEGFA receptor KDR

Wang, Y., La, M., Pham, T., Lovrecz, G. O. & Nie, G., 1 Apr 2019, In : The FASEB Journal. 33, 4, p. 5058-5066 9 p.

Research output: Contribution to journalArticleResearchpeer-review

4 Citations (Scopus)

Host Cell Death Responses to Non-typhoidal Salmonella Infection

Wemyss, M. A. & Pearson, J. S., 26 Jul 2019, In : Frontiers in Immunology. 10, 10 p., 1758.

Research output: Contribution to journalReview ArticleResearchpeer-review

Open Access
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4 Citations (Scopus)

HtrA1 alters endothelial tube formation characteristics in an in vitro model

Singh, H. & Nie, G., 2019, (Accepted/In press) 15 p. bioRxiv.

Research output: Other contributionOther

HtrA4 may play a major role in inhibiting endothelial repair in pregnancy complication preeclampsia

Wang, Y., Lim, R. & Nie, G., 1 Dec 2019, In : Scientific Reports. 9, 1, 14 p., 2728.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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1 Citation (Scopus)

Human Endometrial Extracellular Vesicles Functionally Prepare Human Trophectoderm Model for Implantation: Understanding Bidirectional Maternal-Embryo Communication

Evans, J., Rai, A., Nguyen, H. P. T., Poh, Q. H., Elglass, K., Simpson, R. J., Salamonsen, L. & Greening, D. W., 1 Dec 2019, In : Proteomics. 19, 23, 17 p., 1800423.

Research output: Contribution to journalArticleResearchpeer-review

5 Citations (Scopus)

Interleukin 1 Up-regulates MicroRNA 135b to Promote Inflammation-Associated Gastric Carcinogenesis in Mice

Han, T. S., Voon, D. C. C., Oshima, H., Nakayama, M., Echizen, K., Sakai, E., Yong, Z. W. E., Murakami, K., Yu, L., Minamoto, T., Ock, C. Y., Jenkins, B. J., Kim, S. J., Yang, H. K. & Oshima, M., 1 Mar 2019, In : Gastroenterology. 156, 4, p. 1140-1155.e4 20 p.

Research output: Contribution to journalArticleResearchpeer-review

13 Citations (Scopus)

Interplay between Follistatin, Activin A, and BMP4 Signaling Regulates Postnatal Thymic Epithelial Progenitor Cell Differentiation during Aging

Lepletier, A., Hun, M. L., Hammett, M. V., Wong, K., Naeem, H., Hedger, M., Loveland, K. & Chidgey, A. P., 25 Jun 2019, In : Cell Reports. 27, 13, p. 3887–3901–e4 19 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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6 Citations (Scopus)

Investigation of activin A in inflammatory responses of the testis and its role in the development of testicular fibrosis

Kauerhof, A. C., Nicolas, N., Bhushan, S., Wahle, E., Loveland, K. A., Fietz, D., Bergmann, M., Groome, N. P., Kliesch, S., Schuppe, H-C., Pilatz, A., Meinhardt, A., Hedger, M. P. & Fijak, M., 1 Aug 2019, In : Human Reproduction. 34, 8, p. 1536-1550 15 p.

Research output: Contribution to journalArticleResearchpeer-review

Lnc(ing) interferon production and action

Sen, G. C. & Williams, B. R. G., 1 Sep 2019, In : Cell Research. 29, 9, p. 690-691 2 p.

Research output: Contribution to journalArticleOtherpeer-review

Open Access

Low Serum Levels of HtrA3 at 15 Weeks of Gestation Are Associated with Late-Onset Preeclampsia Development and Small for Gestational Age Birth

Teoh, S. S. Y., Wang, Y., Li, Y., Leemaqz, S. Y-L., Dekker, G. A., Roberts, C. T. & Nie, G., Dec 2019, In : Fetal Diagnosis and Therapy. 46, 6, p. 392-401 10 p.

Research output: Contribution to journalArticleResearchpeer-review

1 Citation (Scopus)

Lupeol, the major compound of the dichloromethane extract of Millettia macrophylla Benth (Fabaceae), displays estrogenic effects in ovariectomized rats

Zingue, S., Ntsa, D. M., Magne Nde, C. B., Michel, T., Ndinteh, D. T., Clyne, C. & Njamen, D., 1 Apr 2019, In : Phytotherapy Research. 33, 4, p. 949-957 9 p.

Research output: Contribution to journalArticleResearchpeer-review

1 Citation (Scopus)

Macrophages, rather than DCs, are responsible for inflammasome activity in the GM-CSF BMDC model

Erlich, Z., Shlomovitz, I., Edry-Botzer, L., Cohen, H., Frank, D., Wang, H., Lew, A. M., Lawlor, K. E., Zhan, Y., Vince, J. E. & Gerlic, M., Apr 2019, In : Nature Immunology. 20, 4, p. 397-406 10 p.

Research output: Contribution to journalLetterResearchpeer-review

19 Citations (Scopus)

Measurement of Mitochondrial Membrane Potential with the Fluorescent Dye Tetramethylrhodamine Methyl Ester (TMRM)

Creed, S. & McKenzie, M., 1 Jan 2019, In : Methods in Molecular Biology. 1928, p. 69-76 8 p.

Research output: Contribution to journalArticleOtherpeer-review

5 Citations (Scopus)

Menstrual fluid factors facilitate tissue repair: identification and functional action in endometrial and skin repair

Evans, J., Infusini, G., McGovern, J., Cuttle, L., Webb, A., Nebl, T., Milla, L., Kimble, R., Kempf, M., Andrews, C. J., Leavesley, D. & Salamonsen, L. A., 1 Jan 2019, In : The FASEB Journal. 33, 1, p. 584-605 22 p.

Research output: Contribution to journalArticleResearchpeer-review

4 Citations (Scopus)

MicroRNA from a 12-h versus 20-h acetylcysteine infusion for paracetamol overdose

Wong, A., Nejad, C., Gantier, M., Choy, K. W., Doery, J. & Graudins, A., 1 Jun 2019, In : Human and Experimental Toxicology. 38, 6, p. 646-654 9 p.

Research output: Contribution to journalArticleResearchpeer-review

2 Citations (Scopus)

miRNA length variation during macrophage stimulation confounds the interpretation of results: implications for miRNA quantification by RT-qPCR

Pillman, K. A., Goodall, G. J., Bracken, C. P. & Gantier, M. P., 1 Feb 2019, In : Rna-A Publication of the Rna Society. 25, 2, p. 232-238 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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3 Citations (Scopus)

Molecular evolution of the switch for progesterone and spironolactone from mineralocorticoid receptor agonist to antagonist

Fuller, P. J., Yao, Y. Z., Jin, R., He, S., Martín-Fernández, B., Young, M. J. & Smith, B. J., 10 Sep 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 116, 37, p. 18578-18583 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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4 Citations (Scopus)

More than 18,000 effectors in the Legionella genus genome provide multiple, independent combinations for replication in human cells

Gomez-Valero, L., Rusniok, C., Carson, D., Mondino, S., Pérez-Cobas, A. E., Rolando, M., Pasricha, S., Reuter, S., Demirtas, J., Crumbach, J., Descorps-Declere, S., Hartland, E. L., Jarraud, S., Dougan, G., Schroeder, G. N., Frankel, G. & Buchrieser, C., 5 Feb 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 116, 6, p. 2265-2273 9 p.

Research output: Contribution to journalArticleResearchpeer-review

31 Citations (Scopus)

Most clinical anti-EGFR antibodies do not neutralize both wtEGFR and EGFRvIII activation in glioma

Greenall, S. A., McKenzie, M., Seminova, E., Dolezal, O., Pearce, L., Bentley, J., Kuchibhotla, M., Chen, S. C., McDonald, K. L., Kornblum, H. I., Endersby, R., Adams, T. E. & Johns, T. G., 1 Aug 2019, In : Neuro-Oncology. 21, 8, p. 1016-1027 12 p.

Research output: Contribution to journalArticleResearchpeer-review

1 Citation (Scopus)

Mutational landscape of ovarian adult granulosa cell tumors from whole exome and targeted TERT promoter sequencing

Alexiadis, M., Rowley, S. M., Chu, S., Leung, D. T. H., Stewart, C. J. R., Amarasinghe, K. C., Campbell, I. G. & Fuller, P. J., 1 Jan 2019, In : Molecular Cancer Research. 17, 1, p. 177-185 9 p.

Research output: Contribution to journalArticleResearchpeer-review

7 Citations (Scopus)

Nod-like receptors are critical for gut–brain axis signalling in mice

Pusceddu, M. M., Barboza, M., Keogh, C. E., Schneider, M., Stokes, P., Sladek, J. A., Kim, H. J. D., Torres-Fuentes, C., Goldfild, L. R., Gillis, S. E., Brust-Mascher, I., Rabasa, G., Wong, K. A., Lebrilla, C., Byndloss, M. X., Maisonneuve, C., Bäumler, A. J., Philpott, D. J., Ferrero, R. L., Barrett, K. E. & 2 others, Reardon, C. & Gareau, M. G., 15 Dec 2019, In : The Journal of Physiology. 597, 24, p. 5777-5797 21 p.

Research output: Contribution to journalArticleResearchpeer-review

5 Citations (Scopus)

Non-invasive fluorescent monitoring of ovarian cancer in an immunocompetent mouse model

Wilson, A. L., Wilson, K. L., Bilandzic, M., Moffitt, L. R., Makanji, M., Gorrell, M. D., Oehler, M. K., Rainczuk, A., Stephens, A. N. & Plebanski, M., 1 Jan 2019, In : Cancers. 11, 1, 19 p., 32.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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3 Citations (Scopus)

Normal foetal kidney volume in offspring of women treated for gestational diabetes

Hokke, S., De Zoysa, N., Carr, B. L., Abruzzo, V., Coombs, P. R., Allan, C. A., East, C., Ingelfinger, J., Puelles, V. G., Black, M. J., Ryan, D., Armitage, J. A., Wallace, E. M., Bertram, J. F. & Cullen-McEwen, L. A., Oct 2019, In : Endocrinology, Diabetes & Metabolism. 2, 4, 9 p., e00091.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Novel Application of the Pfirrmann Disc Degeneration Grading System to 9.4T MRI: Higher Reliability Compared to 3T MRI

Sher, I., Daly, C., Oehme, D., Chandra, R. V., Sher, M., Ghosh, P., Smith, J. & Goldschlager, T., 1 Jul 2019, In : Spine. 44, 13, p. E766-E773 8 p.

Research output: Contribution to journalArticleResearchpeer-review

3 Citations (Scopus)

Pre‐pubertal growth, muscle and fat accumulation in male and female sheep – relationships with metabolic hormone concentrations, timing of puberty and reproductive outcomes

Rosales Nieto, C. A., Ferguson, M. B., Briegel, J. R., Hedger, M. P., Martin, G. B. & Thompson, A. N., 1 Dec 2019, In : Reproduction in Domestic Animals. 54, 12, p. 1596-1603 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Properties and functions of the novel type I interferon epsilon

Marks, Z. R. C., Campbell, N., deWeerd, N. A., Lim, S. S., Gearing, L. J., Bourke, N. M. & Hertzog, P. J., 1 Jun 2019, In : Seminars in Immunology. 43, 9 p., 101328.

Research output: Contribution to journalReview ArticleResearchpeer-review

1 Citation (Scopus)

Rare variants in non-coding regulatory regions of the genome that affect gene expression in systemic lupus erythematosus

Jones, S. A., Cantsilieris, S., Fan, H., Cheng, Q., Russ, B. E., Tucker, E. J., Harris, J., Rudloff, I., Nold, M., Northcott, M., Dankers, W., Toh, A. E. J., White, S. J. & Morand, E. F., 1 Dec 2019, In : Scientific Reports. 9, 1, 9 p., 15433.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Repurposing drugs targeting the P2X7 receptor to limit hyperinflammation and disease during influenza virus infection

Rosli, S., Kirby, F. J., Lawlor, K. E., Rainczuk, K., Drummond, G. R., Mansell, A. & Tate, M. D., Oct 2019, In : British Journal of Pharmacology. 176, 19, p. 3834-3844 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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7 Citations (Scopus)
Open Access
4 Citations (Scopus)

Review: Helicobacter: Inflammation, immunology, and vaccines

Lehours, P. & Ferrero, R. L., 1 Sep 2019, In : Helicobacter. 24, S1, 6 p., e12644.

Research output: Contribution to journalArticleOtherpeer-review

4 Citations (Scopus)

RIPLET, and not TRIM25, is required for endogenous RIG-I-dependent antiviral responses

Hayman, T. J., Hsu, A. C., Kolesnik, T. B., Dagley, L. F., Willemsen, J., Tate, M. D., Baker, P. J., Kershaw, N. J., Kedzierski, L., Webb, A. I., Wark, P. A., Kedzierska, K., Masters, S. L., Belz, G. T., Binder, M., Hansbro, P. M., Nicola, N. A. & Nicholson, S. E., Oct 2019, In : Immunology and Cell Biology. 97, 9, p. 840-852 13 p.

Research output: Contribution to journalArticleResearchpeer-review

7 Citations (Scopus)

Role of NOD1 and ALPK1/TIFA signalling in innate immunity against helicobacter pylori infection

Ying, L. & Ferrero, R. L., 24 May 2019, Molecular Mechanisms of Inflammation: Induction, Resolution and Escape by Helicobacter pylori. Backer, S. (ed.). Switzerland: Springer, p. 159-177 19 p. (Current Topics in Microbiology and Immunology; vol. 421).

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Otherpeer-review

2 Citations (Scopus)

Salmonella effectors SseK1 and SseK3 target death domain proteins in the TNF and TRAIL signaling pathways

Newson, J., Scott, N. E., Chung, I. Y. W., Lung, T. W. F., Giogha, C., Gan, J., Wang, N., Strugnell, R., Brown, N. F., Cygler, M., Pearson, J. & Hartland, E., 1 Jun 2019, In : Molecular & Cellular Proteomics. 18, 6, p. 1138-1156 19 p.

Research output: Contribution to journalArticleResearchpeer-review

9 Citations (Scopus)

Serine-phosphorylated STAT3 promotes tumorigenesis via modulation of RNA polymerase transcriptional activity

Balic, J. J., Garama, D. J., Saad, M. I., Yu, L., West, A. C., West, A. J., Livis, T., Bhathal, P. S., Gough, D. J. & Jenkins, B. J., 15 Oct 2019, In : Cancer Research. 79, 20, p. 5272-5287 16 p.

Research output: Contribution to journalArticleResearchpeer-review

2 Citations (Scopus)

Serum podocalyxin at 11–13 weeks of gestation in the prediction of small for gestational age neonates

Rolnik, D. L., Wang, Y., Hyett, J., Silva Costa, F. D. & Nie, G., 1 Jun 2019, In : Journal of Perinatology. 39, 6, p. 784-790 7 p.

Research output: Contribution to journalArticleResearchpeer-review

SIDT1 localizes to endolysosomes and mediates double-stranded RNA transport into the cytoplasm

Nguyen, T. A., Smith, B. R. C., Elgass, K. D., Creed, S. J., Cheung, S., Tate, M. D., Belz, G. T., Wicks, I. P., Masters, S. L. & Pang, K. C., 15 Jun 2019, In : Journal of Immunology. 202, 12, p. 3483-3492 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Stressing out the mitochondria: Mechanistic insights into NLRP3 inflammasome activation

Yabal, M., Calleja, D. J., Simpson, D. S. & Lawlor, K. E., Feb 2019, In : Journal of leukocyte biology. 105, 2, p. 377-399 23 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

14 Citations (Scopus)

Stunted microbiota and opportunistic pathogen colonization in caesarean-section birth

Shao, Y., Forster, S. C., Tsaliki, E., Vervier, K., Strang, A., Simpson, N., Kumar, N., Stares, M. D., Rodger, A., Brocklehurst, P., Field, N. & Lawley, T. D., 1 Oct 2019, In : Nature. 574, 7776, p. 117-121 5 p.

Research output: Contribution to journalArticleResearchpeer-review

40 Citations (Scopus)

Sugar Fix Keeps RIPK3 at Bay

Giogha, C. & Lawlor, K. E., 19 Mar 2019, In : Immunity. 50, 3, p. 539-541 3 p.

Research output: Contribution to journalShort SurveyOtherpeer-review

Synergistic Combination of Polymyxin B and Enrofloxacin Induced Metabolic Perturbations in Extensive Drug-resistant Pseudomonas aeruginosa

Lin, Y-W., Han, M-L., Zhao, J., Zhu, Y., Rao, G., Forrest, A., Song, J., Kaye, K. S., Hertzog, P., Purcell, A., Creek, D., Zhou, T. Q., Velkov, T. & Li, J., 3 Oct 2019, In : Frontiers in Pharmacology. 10, 11 p., 1146.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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1 Citation (Scopus)

Tanking influenza a virus in the lung

Rosli, S. & Tate, M. D., 1 Mar 2019, In : American Journal of Respiratory Cell and Molecular Biology. 60, 3, p. 255-256 2 p.

Research output: Contribution to journalEditorialOtherpeer-review

Targeting endosomal NOX2 as a potential therapy to limit influenza A virus infection

Laghlali, G. & Tate, M. D., Oct 2019, In : Respirology. 24, 10, p. 935-936 2 p.

Research output: Contribution to journalEditorialOtherpeer-review

Open Access

Targeting XIAP and PPARγ in granulosa cell tumors alters metabolic signaling

Leung, T. H., Rainczuk, A., Nguyen, T., Stephens, A., Silke, J., Fuller, P. J. & Chu, S., 5 Apr 2019, In : Journal of Proteome Research. 18, 4, p. 1691-1701 11 p.

Research output: Contribution to journalArticleResearchpeer-review

1 Citation (Scopus)

The cytoskeleton in spermatogenesis

Dunleavy, J. E. M., O'Bryan, M. K., Stanton, P. G. & O'Donnell, L., 1 Jan 2019, In : Reproduction. 157, 2, p. R53-R72 20 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

10 Citations (Scopus)

The future of faecal transplants

Giles, E. M., D’Adamo, G. L. & Forster, S. C., 1 Dec 2019, In : Nature Reviews Microbiology. 17, 12, 1 p.

Research output: Contribution to journalComment / DebateOtherpeer-review

3 Citations (Scopus)

The microgenderome revealed: sex differences in bidirectional interactions between the microbiota, hormones, immunity and disease susceptibility

Vemuri, R., Sylvia, K. E., Klein, S. L., Forster, S. C., Plebanski, M., Eri, R. & Flanagan, K. L., 15 Mar 2019, In : Seminars in Immunopathology. 41, 2, p. 265-275 11 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

21 Citations (Scopus)

The mouse as a model for pulmonary Legionella infection

Ng, G. Z., Solomatina, A., van Driel, I. R. & Hartland, E. L., 1 Jan 2019, Legionella: Methods and Protocols. Buchrieser, C. & Hilbi, H. (eds.). 2nd ed. New York, NY: Humana Press, p. 399-417 19 p. (Methods in Molecular Biology; vol. 1921).

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Otherpeer-review

Therapeutically exploiting STAT3 activity in cancer — using tissue repair as a road map

Huynh, J., Chand, A., Gough, D. & Ernst, M., 1 Feb 2019, In : Nature Reviews Cancer. 19, 2, p. 82-96 15 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

66 Citations (Scopus)

The Single Nucleotide Polymorphism Mal-D96N Mice Provide New Insights into Functionality of Mal in TLR Immune Responses

Dowling, J. K., Tate, M. D., Rosli, S., Bourke, N. M., Bitto, N., Lauterbach, M. A., Cheung, S., Ve, T., Kobe, B., Golenbock, D. & Mansell, A., 15 Apr 2019, In : Journal of Immunology. 202, 8, p. 2384-2396 13 p.

Research output: Contribution to journalArticleResearchpeer-review

1 Citation (Scopus)