Hudson Institute - Department of Molecular and Translational Science

Research Output

2017

Phosphoproteomic profiling reveals ALK and MET as novel actionable targets across synovial sarcoma subtypes

Fleuren, E. D. G., Vlenterie, M., Van Der Graaf, W. T. A., Hillebrandt-Roeffen, M. H. S., Blackburn, J., Ma, X., Chan, H., Magias, M. C., Van Erp, A., Van Houdt, L., Cebeci, S. A. S., Van De Ven, A., Flucke, U. E., Heyer, E. E., Thomas, D. M., Lord, C. J., Marini, K. D., Vaghjiani, V., Mercer, T. R., Cain, J. E. & 3 others, Wu, J., Versleijen-Jonkers, Y. M. H. & Daly, R. J., 15 Aug 2017, In : Cancer Research. 77, 16, p. 4279-4292 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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12 Citations (Scopus)

Porphyromonas gulae activates unprimed and gamma interferon-primed macrophages via the pattern recognition receptors Toll-like receptor 2 (TLR2), TLR4, and NOD2

Holden, J. A., O'Brien-Simpson, N. M., Lenzo, J. C., Orth, R. K. H., Mansell, A. & Reynolds, E. C., 1 Sep 2017, In : Infection and Immunity. 85, 9, 15 p., e00282-17.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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4 Citations (Scopus)

Positional modification techniques for supine obstructive sleep apnea: A systematic review and meta-analysis

Barnes, H., Edwards, B. A., Joosten, S. A., Naughton, M. T., Hamilton, G. S. & Dabscheck, E., Dec 2017, In : Sleep Medicine Reviews. 36, p. 107-115 9 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

29 Citations (Scopus)

Positive regulatory interactions between YAP and Hedgehog signalling in skin homeostasis and BCC development in mouse skin in vivo

Akladios, B., Mendoza Reinoso, V., Cain, J. E., Wang, T., Lambie, D. L., Watkins, D. N. & Beverdam, A., 1 Aug 2017, In : PLoS ONE. 12, 8, 15 p., e0183178.

Research output: Contribution to journalArticleResearchpeer-review

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9 Citations (Scopus)

Post-translational Mechanisms of Host Subversion by Bacterial Effectors

Scott, N. E. & Hartland, E. L., 1 Dec 2017, In : Trends in Molecular Medicine. 23, 12, p. 1088-1102 15 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

6 Citations (Scopus)

Posttranslational modification as a critical determinant of cytoplasmic innate immune recognition

Baker, P. J., De Nardo, D., Moghaddas, F., Tran, L. S., Bachem, A., Nguyen, T., Hayman, T., Tye, H., Vince, J. E., Bedoui, S., Ferrero, R. L. & Masters, S. L., 14 Jun 2017, In : Physiological Reviews. 97, 3, p. 1165-1209 45 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

17 Citations (Scopus)

Potential efficacy of interleukin-1β inhibition in lung cancer

Jenkins, B. J., 21 Oct 2017, In : The Lancet. 390, 10105, p. 1813-1814 2 p.

Research output: Contribution to journalComment / DebateOtherpeer-review

Open Access
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3 Citations (Scopus)

Potential pitfall of pluripotent stem cells

Trounson, A., 3 Aug 2017, In : The New England Journal of Medicine. 377, 5, p. 490-491 2 p.

Research output: Contribution to journalShort SurveyOtherpeer-review

9 Citations (Scopus)

PRC2 is required for extensive reorganization of H3K27me3 during epigenetic reprogramming in mouse fetal germ cells

Prokopuk, L., Stringer, J. M., Hogg, K., Elgass, K. D. & Western, P. S., 20 Feb 2017, In : Epigenetics and Chromatin. 10, 1, 20 p., 7.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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16 Citations (Scopus)

Red Cell Alloimmunisation Is Associated with Development of Autoantibodies and Increased Red Cell Transfusion Requirements in Myelodysplastic Syndromes (MDS)

Singhal, D., Kutyna, M. M., Chhetri, R., Wee, A., Hague, S., Nath, L., Nath, S. V., Sinha, R., Wickham, N., Lewis, I. D., Ross, D. M., Bardy, P. G., To, L. B., Reynolds, J., Wood, E., Roxby, D. J. & Hiwase, D. K., 7 Dec 2017, In : Blood. 130, Suppl 1, p. 2411 1 p.

Research output: Contribution to journalMeeting AbstractOtherpeer-review

Regional reproductive quests: Cross-border reproductive travel among infertile Indonesian couples

Bennett, L. & Pangestu, M., 1 Aug 2017, In : Asia Pacific Viewpoint. 58, 2, p. 162-174 13 p.

Research output: Contribution to journalArticleResearchpeer-review

3 Citations (Scopus)

Regulation and functions of inflammasome-mediated cytokines in Helicobacter pylori infection

Tran, L. S., Chonwerawong, M. & Ferrero, R. L., 2017, In : Microbes and Infection. 19, 9-10, p. 449-458 10 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

11 Citations (Scopus)

Risk Factors for Hospital Readmission and Follow Up after NICU Discharge of Infants Born at Extremely Low Gestational Age in Metropolitan Melbourne

Doctor, T. N., Harnaen, E., Seith, B., Tan, K. & Craig, S., 2017, In : International Journal of Pediatric Research. 3, 1, 7 p., 028.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Serum podocalyxin is significantly increased in early-onset preeclampsia and may represent a novel marker of maternal endothelial cell dysfunction

Chen, Q., Wang, Y., Li, Y., Zhao, M. & Nie, G., Nov 2017, In : Journal of Hypertension. 35, 11, p. 2287-2294 8 p.

Research output: Contribution to journalArticleResearchpeer-review

6 Citations (Scopus)

SIDT2 Transports Extracellular dsRNA into the Cytoplasm for Innate Immune Recognition

Nguyen, T. A., Smith, B. R. C., Tate, M. D., Belz, G. T., Barrios, M. H., Elgass, K. D., Weisman, A. S., Baker, P. J., Preston, S. P., Whitehead, L. W., Garnham, A. L., Lundie, R. J., Smyth, G. K., Pellegrini, M., O'Keeffe, M., Wicks, I. P., Masters, S. L., Hunter, C. P. & Pang, K. C., 19 Sep 2017, In : Immunity. 47, 3, p. 498-509 12 p.

Research output: Contribution to journalArticleResearchpeer-review

24 Citations (Scopus)

Signaling by TGF-betas in tubule cultures of adult rat testis

Chan, K. H., Galuska, S. P., Kudipudi, P. K., Riaz, M. A., Loveland, K. L. & Konrad, L., 2017, In : American Journal of Translational Research. 9, 3, p. 1173-1182 10 p., AJTR0034593.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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3 Citations (Scopus)

Simultaneous measurement of mitochondrial calcium and mitochondrial membrane potential in live cells by fluorescent microscopy

McKenzie, M., Lim, S. C. & Duchen, M. R., 24 Jan 2017, In : Journal of Visualized Experiments. 2017, 119, 6 p., e55166.

Research output: Contribution to journalArticleOtherpeer-review

8 Citations (Scopus)

Soluble Delta-like ligand 1 alters human endometrial epithelial cell adhesive capacity

Van Sinderen, M., Oyanedel, J., Menkhorst, E., Cuman, C., Rainczuk, K., Winship, A., Salamonsen, L., Edgell, T. & Dimitriadis, E., 2017, In : Reproduction, Fertility and Development. 29, 4, p. 694-702 9 p.

Research output: Contribution to journalArticleResearchpeer-review

3 Citations (Scopus)

Solution structure of the TLR adaptor MAL/TIRAP reveals an intact BB loop and supports MAL Cys91 glutathionylation for signaling

Hughes, M. M., Lavrencic, P., Coll, R. C., Ve, T., Ryan, D. G., Williams, N. C., Menon, D., Mansell, A., Board, P. G., Mobli, M., Kobe, B. & O’Neill, L. A. J., 8 Aug 2017, In : Proceedings of the National Academy of Sciences of the United States of America. 114, 32, p. E6480-E6489 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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16 Citations (Scopus)

Structural basis of TIR-domain-assembly formation in MAL- and MyD88-dependent TLR4 signaling

Ve, T., Vajjhala, P. R., Hedger, A., Croll, T., Dimaio, F., Horsefield, S., Yu, X., Lavrencic, P., Hassan, Z., Morgan, G. P., Mansell, A., Mobli, M., O'Carroll, A., Chauvin, B., Gambin, Y., Sierecki, E., Landsberg, M. J., Stacey, K. J., Egelman, E. H. & Kobe, B., 7 Sep 2017, In : Nature Structural & Molecular Biology. 24, 9, p. 743-751 9 p.

Research output: Contribution to journalArticleResearchpeer-review

34 Citations (Scopus)

Suppressor of cytokine signaling (SOCS)5 ameliorates influenza infection via inhibition of EGFR signaling

Kedzierski, L., Tate, M., Hsu, A. C., Kolesnik, T. B., Linossi, E. M., Dagley, L., Dong, Z., Freeman, S., Infusini, G., Starkey, M. R., Bird, N. L., Chatfield, S. M., Babon, J. J., Huntington, N., Belz, G., Webb, A., Wark, P. AB., Nicola, N. A., Xu, J., Kedzierska, K. & 2 others, Hansbro, P. M. & Nicholson, S. E., 14 Feb 2017, In : eLife. 6, 27 p., e20444.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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27 Citations (Scopus)

Survey of reproductive experiences and outcomes of cancer survivors who stored reproductive material before treatment

Hammarberg, K., Kirkman, M., Stern, C., McLachlan, R. I., Clarke, G., Agresta, F., Gook, D., Rombauts, L., Vollenhoven, B. & Fisher, J. R. W., 1 Jan 2017, In : Human Reproduction. 32, 12, p. 2423-2430 8 p., dex314.

Research output: Contribution to journalReview ArticleResearchpeer-review

4 Citations (Scopus)

Targeted Therapy for Severe Asthma: Identifying the Right Patients

Low, K. & Bardin, P. G., 1 Jun 2017, In : Molecular Diagnosis and Therapy. 21, 3, p. 235-247 13 p.

Research output: Contribution to journalArticleResearchpeer-review

4 Citations (Scopus)

Targeting the seeds of small cell lung cancer

Mahara, S. & Firestein, R., 1 Mar 2017, In : Annals of Translational Medicine. 5, 5, 113.

Research output: Contribution to journalArticleOtherpeer-review

Testis determination requires a specific FGFR2 isoform to repress FOXL2

Bagheri-Fam, S., Bird, A. D., Zhao, L., Ryan, J. M., Yong, M., Wilhelm, D., Koopman, P., Eswarakumar, V. P. & Harley, V. R., 1 Nov 2017, In : Endocrinology. 158, 11, p. 3832-3843 12 p.

Research output: Contribution to journalArticleResearchpeer-review

9 Citations (Scopus)

The human amnion epithelial cell secretome decreases hepatic fibrosis in mice with chronic liver fibrosis

Alhomrani, M., Correia, J., Zavou, M., Leaw, B., Kuk, N., Xu, R., Saad, M. I., Hodge, A., Greening, D. W., Lim, R. & Sievert, W., 24 Oct 2017, In : Frontiers in Pharmacology. 8, OCT, 13 p., 748.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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16 Citations (Scopus)

The immune modulatory peptide FhHDM-1 secreted by the helminth Fasciola hepatica prevents NLRP3 inflammasome activation by inhibiting endolysosomal acidification in macrophages

Alvarado, R., To, J., Lund, M. E., Pinar, A., Mansell, A., Robinson, M. W., O'Brien, B. A., Dalton, J. P. & Donnelly, S. M., 1 Jan 2017, In : The FASEB Journal. 31, 1, p. 85-95 11 p.

Research output: Contribution to journalArticleResearchpeer-review

24 Citations (Scopus)

The innate immune receptor MDA5 limits rotavirus infection but promotes cell death and pancreatic inflammation

Dou, Y., Yim, H. C. H., Kirkwood, C. D., Williams, B. R. G. & Sadler, A. J., 15 Sep 2017, In : The EMBO Journal. 36, 18, p. 2742-2757 16 p.

Research output: Contribution to journalArticleResearchpeer-review

8 Citations (Scopus)

The molecular characterization of porcine egg precursor cells

Tsai, T-S., Johnson, J., White, Y. & St John, J. C., 2017, In : Oncotarget. 8, 38, p. 63484-63505 22 p.

Research output: Contribution to journalArticleResearchpeer-review

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The nicer side of innate immunity: Wound healing and tissue regeneration

Sweet, M. J. & Mansell, A., 1 Jan 2017, In : Seminars in Cell and Developmental Biology. 61, p. 1-2 2 p.

Research output: Contribution to journalEditorialOtherpeer-review

The ovarian reserve is depleted during puberty in a hormonally driven process dependent on the pro-Apoptotic protein BMF

Liew, S. H., Nguyen, Q. N., Strasser, A., Findlay, J. K. & Hutt, K. J., 3 Aug 2017, In : Cell Death and Disease. 8, 8, e2971.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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11 Citations (Scopus)

The presence and impact of estrogen metabolism on the biology of triple-negative breast cancer

McNamara, K. M., Oguro, S., Omata, F., Kikuchi, K., Guestini, F., Suzuki, K., Yang, Y., Abe, E., Hirakawa, H., Brown, K. A., Takanori, I., Ohuchi, N. & Sasano, H., 1 Jan 2017, In : Breast Cancer Research and Treatment. 161, 2, p. 213-227 15 p.

Research output: Contribution to journalArticleResearchpeer-review

7 Citations (Scopus)

Therapeutically blocking Interleukin-11 Receptor-α enhances doxorubicin cytotoxicity in high grade type I endometrioid tumours

Winship, A., Van Sinderen, M., Rainczuk, K. & Dimitriadis, E., 2017, In : Oncotarget. 8, 14, p. 22716-22729 14 p.

Research output: Contribution to journalArticleResearchpeer-review

6 Citations (Scopus)

The role of canonical and non-canonical Hedgehog signaling in tumor progression in a mouse model of small cell lung cancer

Szczepny, A., Rogers, S., Jayasekara, W. S. N., Park, K., McCloy, R. A., Cochrane, C. R., Ganju, V., Cooper, W. A., Sage, J., Peacock, C. D., Cain, J. E., Burgess, A. & Watkins, D. N., 28 Sep 2017, In : Oncogene. 36, 39, p. 5544-5550 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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26 Citations (Scopus)

The significance of post-translational removal of α-DG-N in early stage endometrial cancer development

Heng, S., Evans, J., Salamonsen, L. A., Jobling, T. W. & Nie, G., 1 Jan 2017, In : Oncotarget. 8, 47, p. 81942-81952 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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3 Citations (Scopus)

The skin barrier function gene SPINK5 is associated with challenge-proven IgE-mediated food allergy in infants

Ashley, S. E., Tan, H. T. T., Vuillermin, P., Dharmage, S. C., Tang, M. L. K., Koplin, J., Gurrin, L. C., Lowe, A., Lodge, C., Ponsonby, A. -L., Molloy, J., Martin, P., Matheson, M. C., Saffery, R., Allen, K. J., Ellis, J. A., Martino, D., the HealthNuts team & on behalf of the Barwon Infant Study, the Melbourne Atopy Cohort study, the Peanut Allergen Threshold Study and the Probiotic and Peanut Oral ImmunoTherapy study, Sep 2017, In : Allergy. 72, 9, p. 1356 - 1364

Research output: Contribution to journalArticleResearchpeer-review

29 Citations (Scopus)

The therapeutic benefit of bacterial membrane vesicles

Bitto, N. J. & Kaparakis-Liaskos, M., 16 Jun 2017, In : International Journal of Molecular Sciences. 18, 6, 1287.

Research output: Contribution to journalReview ArticleOtherpeer-review

Open Access
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16 Citations (Scopus)

TLR agonists as adjuvants for cancer vaccines

Li, J. K., Balic, J. J., Yu, L. & Jenkins, B., 2017, Advances in Experimental Medicine and Biology. Cohen, I. R., Lajtha, A., Lambris, J. D. & Paoletti, R. (eds.). Gateway East Singapore: Springer, Vol. 1024. p. 195-212 18 p. (Advances in Experimental Medicine and Biology; vol. 1024).

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Otherpeer-review

Open Access
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11 Citations (Scopus)

Topoisomerase 1 inhibition promotes cyclic GMP-AMP synthase-dependent antiviral responses

Pépin, G., Nejad, C., Ferrand, J., Thomas, B. J., Stunden, H. J., Sanij, E., Foo, C. H., Stewart, C. R., Cain, J. E., Bardin, P. G., Williams, B. R. G. & Gantier, M. P., 1 Sep 2017, In : mBio. 8, 5, 9 p., e01611-17.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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6 Citations (Scopus)

Transcriptional dysregulation of Interferome in experimental and human Multiple Sclerosis

Srinivasan, S., Severa, M., Rizzo, F., Menon, R., Brini, E., Mechelli, R., Martinelli, V., Hertzog, P., Salvetti, M., Furlan, R., Martino, G., Comi, G., Coccia, E. & Farina, C., 1 Dec 2017, In : Scientific Reports. 7, 1, 9 p., 8981.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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6 Citations (Scopus)
6 Citations (Scopus)

Transmission of the gut microbiota: spreading of health

Browne, H. P., Neville, B. A., Forster, S. C. & Lawley, T. D., 1 Sep 2017, In : Nature Reviews Microbiology. 15, 9, p. 531-543 13 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

44 Citations (Scopus)

Understanding immune phenotypes in human gastric disease tissues by multiplexed immunohistochemistry

Ying, L., Yan, F., Meng, Q., Yuan, X., Yu, L., Williams, B. R. G., Chan, D. W., Shi, L., Tu, Y., Ni, P., Wang, X., Xu, D. & Hu, Y., 12 Oct 2017, In : Journal of Translational Medicine. 15, 1, 11 p., 206.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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5 Citations (Scopus)

Validation and application of a novel integrated genetic screening method to a cohort of 1,112 men with idiopathic azoospermia or severe oligozoospermia

Oud, M. S., Ramos, L., O'Bryan, M. K., McLachlan, R. I., Okutman, O., Viville, S., de Vries, P. F., Smeets, D. F. C. M., Lugtenberg, D., Hehir-Kwa, J. Y., Gilissen, C., van de Vorst, M., Vissers, L. E. L. M., Hoischen, A., Meijerink, A. M., Fleischer, K., Veltman, J. A. & Noordam, M. J., Nov 2017, In : Human Mutation. 38, 11, p. 1592-1605 14 p.

Research output: Contribution to journalArticleResearchpeer-review

15 Citations (Scopus)
2016

Activating transcription factor 3 expression as a marker of response to the histone deacetylase inhibitor pracinostat

Sooraj, D., Xu, D., Cain, J. E., Gold, D. P. & Williams, B. R. G., 1 Jul 2016, In : Molecular Cancer Therapeutics. 15, 7, p. 1726-1739 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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5 Citations (Scopus)

A high-throughput assay for the detection of α-dystroglycan N-Terminus in human uterine fluid to determine uterine receptivity

Heng, S., Vollenhoven, B., Rombauts, L. J. & Nie, G., Apr 2016, In : Journal of Biomolecular Screening. 21, 4, p. 408 - 413 6 p.

Research output: Contribution to journalArticleResearchpeer-review

2 Citations (Scopus)

Aldosterone secretion and action

Fuller, P. J. & Young, M. J., 2016, Endocrinology: Adult and Pediatric. Jameson, J. L., De Groot, L. J., de Kretser, D. M., Giudice, L. C., Grossman, A. B., Melmed, S., Potts Jr, J. T. & Weir, G. C. (eds.). 7th ed. Philadelphia PA USA: Elsevier, Vol. 2. p. 1756-1762 7 p.

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Otherpeer-review

Analysis of mitochondrial DNA copy number and its regulation through DNA methylation of POLGA

Sun, X., Lee, W., Vaghjiani, V. & St. John, J. C., 2016, Methods in Molecular Biology. McKenzie, M. (ed.). 3rd ed. Humana Press, Vol. 1351. p. 131-141 11 p. (Methods in Molecular Biology; vol. 1351).

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Otherpeer-review

1 Citation (Scopus)

Analysis of the mitochondrial DNA and its replicative capacity in induced pluripotent stem cells

Cagnone, G., Vaghjiani, V., Lee, W., Sun, C., Johnson, J., Yeung, K-Y. & St.John, J. C., 1 Jan 2016, Induced Pluripotent Stem (iPS) Cells: Methods and Protocols. Turksen, K. & Nagy, A. (eds.). New York NY USA: Humana Press, Vol. 1357. p. 231-267 37 p. (Methods in Molecular Biology; vol. 1357).

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Otherpeer-review

1 Citation (Scopus)

Antitumour actions of interferons: Implications for cancer therapy

Parker, B. S., Rautela, J. & Hertzog, P. J., 1 Mar 2016, In : Nature Reviews Cancer. 16, 3, p. 131-144 14 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

294 Citations (Scopus)