Hudson Institute - Department of Molecular and Translational Science

Research Output

2020

Connexin-Dependent Transfer of cGAMP to Phagocytes Modulates Antiviral Responses

Pépin, G., De Nardo, D., Rootes, C. L., Ullah, T. R., Al-Asmari, S. S., Balka, K. R., Li, H-M., Quinn, K. M., Moghaddas, F., Chappaz, S., Kile, B. T., Morand, E. F., Masters, S. L., Stewart, C. R., Williams, B. R. G. & Gantier, M. P., 28 Jan 2020, In : mBio. 11, 1, 6 p., e03187-19.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Differential tissue-specific damage caused by bacterial epididymo-orchitis in the mouse

Klein, B., Bhushan, S., Gunther, S., Middendorff, R., Loveland, K., Hedger, M. & Meinhardt, A., 3 Feb 2020, (Accepted/In press) In : Molecular Human Reproduction. 44 p.

Research output: Contribution to journalArticleResearchpeer-review

Diverse effects of interferon alpha on the establishment and reversal of HIV latency

van der Sluis, R. M., Zerbato, J. M., Rhodes, J. W., Pascoe, R. D., Solomon, A., Kumar, N. A., Dantanarayana, A. I., Tennakoon, S., Dufloo, J., McMahon, J., Chang, J. J., Evans, V. A., Hertzog, P. J., Jakobsen, M. R., Harman, A. N., Lewin, S. R. & Cameron, P. U., 1 Jan 2020, In : PLoS Pathogens. 16, 2, 27 p., e1008151.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Editorial: Immunomodulation of innate immune cells

Almeida, C. R., Bottazzi, B., De Nardo, D. & Lawlor, K. E., 11 Feb 2020, In : Frontiers in Immunology. 3 p., 101.

Research output: Contribution to journalEditorialOtherpeer-review

Open Access
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Elevated circulating HtrA4 in preeclampsia may alter endothelial expression of senescence genes

Wang, Y., Lim, R. & Nie, G., 15 Jan 2020, In : Placenta. 90, p. 71-81 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Mutations that prevent caspase cleavage of RIPK1 cause autoinflammatory disease

Lalaoui, N., Boyden, S. E., Oda, H., Wood, G. M., Stone, D. L., Chau, D., Liu, L., Stoffels, M., Kratina, T., Lawlor, K. E., Zaal, K. J. M., Hoffmann, P. M., Etemadi, N., Shield-Artin, K., Biben, C., Tsai, W. L., Blake, M. D., Kuehn, H. S., Yang, D., Anderton, H. & 34 others, Silke, N., Wachsmuth, L., Zheng, L., Moura, N. S., Beck, D. B., Gutierrez-Cruz, G., Ombrello, A. K., Pinto-Patarroyo, G. P., Kueh, A. J., Herold, M. J., Hall, C., Wang, H., Chae, J. J., Dmitrieva, N. I., McKenzie, M., Light, A., Barham, B. K., Jones, A., Romeo, T. M., Zhou, Q., Aksentijevich, I., Mullikin, J. C., Gross, A. J., Shum, A. K., Hawkins, E. D., Masters, S. L., Lenardo, M. J., Boehm, M., Rosenzweig, S. D., Pasparakis, M., Voss, A. K., Gadina, M., Kastner, D. L. & Silke, J., 2 Jan 2020, In : Nature. 577, 7788, p. 103-108 6 p.

Research output: Contribution to journalArticleResearchpeer-review

4 Citations (Scopus)

Parsing the IL-37-mediated suppression of inflammasome function

Rudloff, I., Ung, H. K., Dowling, J. K., Mansell, A., D'Andrea, L., Ellisdon, A. M., Whisstock, J., Berger, P., Nold, C. & Nold, M., Jan 2020, In : Cells. 9, 1, 19 p., 178.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Pre-operative sera interleukin-6 in the diagnosis of high-grade serous ovarian cancer

Kampan, N. C., Madondo, M. T., Reynolds, J., Hallo, J., McNally, O. M., Jobling, T. W., Stephens, A. N., Quinn, M. A. & Plebanski, M., 10 Feb 2020, In : Scientific Reports. 10, 1, 15 p., 2213.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Ptpn6 inhibits caspase-8- and Ripk3/Mlkl-dependent inflammation

Speir, M., Nowell, C. J., Chen, A. A., O’Donnell, J. A., Shamie, I. S., Lakin, P. R., D’Cruz, A. A., Braun, R. O., Babon, J. J., Lewis, R. S., Bliss-Moreau, M., Shlomovitz, I., Wang, S., Cengia, L. H., Stoica, A. I., Hakem, R., Kelliher, M. A., O’Reilly, L. A., Patsiouras, H., Lawlor, K. E. & 5 others, Weller, E., Lewis, N. E., Roberts, A. W., Gerlic, M. & Croker, B. A., 1 Jan 2020, In : Nature Immunology. 21, 1, p. 54-64 11 p.

Research output: Contribution to journalArticleResearchpeer-review

2019

A cell type-specific transcriptomic approach to map B cell and monocyte type I interferon-linked pathogenic signatures in Multiple Sclerosis

Severa, M., Rizzo, F., Srinivasan, S., Di Dario, M., Giacomini, E., Buscarinu, M. C., Cruciani, M., Etna, M. P., Sandini, S., Mechelli, R., Farina, A., Trivedi, P., Hertzog, P. J., Salvetti, M., Farina, C. & Coccia, E. M., 1 Jul 2019, In : Journal of Autoimmunity. 101, p. 1-16 16 p.

Research output: Contribution to journalArticleResearchpeer-review

1 Citation (Scopus)

Activin A target genes are differentially expressed between normal and neoplastic adult human testes: clues to gonocyte fate choice

Szarek, M., Bergmann, M., Konrad, L., Schuppe, H. C., Kliesch, S., Hedger, M. P. & Loveland, K. A. L., 1 Jan 2019, In : Andrology. 7, 1, p. 31-41 11 p.

Research output: Contribution to journalArticleResearchpeer-review

2 Citations (Scopus)

Activins, follistatin and immunoregulation in the epididymis

Wijayarathna, R. & Hedger, M. P., 19 Jul 2019, (Accepted/In press) In : Andrology. 9 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

Acute heat-treatment disrupts inhibin-related protein production and gene expression in the adult rat testis

Aldahhan, R. A., Stanton, P., Ludlow, H., de Kretser, D. & Hedger, M., 1 Dec 2019, In : Molecular and Cellular Endocrinology. 498, 12 p., 110546.

Research output: Contribution to journalArticleResearchpeer-review

ADAM17: An emerging therapeutic target for lung cancer

Saad, M. I., Rose-John, S. & Jenkins, B. J., 21 Aug 2019, In : Cancers. 11, 9, 28 p., 1218.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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2 Citations (Scopus)

ADAM17 selectively activates the IL-6 trans-signaling/ERK MAPK axis in KRAS-addicted lung cancer

Saad, M. I., Alhayyani, S., McLeod, L., Yu, L., Alanazi, M., Deswaerte, V., Tang, K., Jarde, T., Smith, J. A., Prodanovic, Z., Tate, M. D., Balic, J. J., Watkins, D. N., Cain, J. E., Bozinovski, S., Algar, E., Kohmoto, T., Ebi, H., Ferlin, W., Garbers, C. & 4 others, Ruwanpura, S., Sagi, I., Rose-John, S. & Jenkins, B. J., Apr 2019, In : EMBO Molecular Medicine. 11, 4, 19 p., e9976.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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4 Citations (Scopus)

A human gut bacterial genome and culture collection for improved metagenomic analyses

Forster, S. C., Kumar, N., Anonye, B. O., Almeida, A., Viciani, E., Stares, M. D., Dunn, M., Mkandawire, T. T., Zhu, A., Shao, Y., Pike, L. J., Louie, T., Browne, H. P., Mitchell, A. L., Neville, B. A., Finn, R. D. & Lawley, T. D., 1 Feb 2019, In : Nature Biotechnology. 37, 2, p. 186-192 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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38 Citations (Scopus)

A new genomic blueprint of the human gut microbiota

Almeida, A., Mitchell, A. L., Boland, M., Forster, S. C., Gloor, G. B., Tarkowska, A., Lawley, T. D. & Finn, R. D., 25 Apr 2019, In : Nature. 568, 7753, p. 499-504 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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68 Citations (Scopus)

A novel “embryo-endometrial” adhesion model can potentially predict “receptive” or “non-receptive” endometrium

Evans, J., Walker, K. J., Bilandzic, M., Kinnear, S. & Salamonsen, L., 27 Nov 2019, (Accepted/In press) In : Journal of Assisted Reproduction and Genetics. 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Anti-Helicobacter pylori activity of ethoxzolamide

Modak, J. K., Tikhomirova, A., Gorrell, R. J., Rahman, M. M., Kotsanas, D., Korman, T. M., Garcia-Bustos, J., Kwok, T., Ferrero, R. L., Supuran, C. T. & Roujeinikova, A., 1 Dec 2019, In : Journal of Enzyme Inhibition and Medicinal Chemistry. 34, 1, p. 1660-1667 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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1 Citation (Scopus)

A step toward making human oocytes

Stringer, J. M. & Western, P. S., 3 Jan 2019, In : Nature Biotechnology. 37, 1, p. 24-25 2 p.

Research output: Contribution to journalEditorialOther

A structural "star" in interferon gamma signaling

Hertzog, P. J. & de Weerd, N. A., 1 May 2019, In : Immunology and Cell Biology. 97, 5, p. 442-444 3 p.

Research output: Contribution to journalArticleOtherpeer-review

Open Access
1 Citation (Scopus)

Author Correction: Human sex reversal is caused by duplication or deletion of core enhancers upstream of SOX9 (Nature Communications, (2018), 9, 1, (5319), 10.1038/s41467-018-07784-9)

Croft, B., Ohnesorg, T., Hewitt, J., Bowles, J., Quinn, A., Tan, J., Corbin, V., Pelosi, E., van den Bergen, J., Sreenivasan, R., Knarston, I., Robevska, G., Vu, D. C., Hutson, J., Harley, V., Ayers, K., Koopman, P. & Sinclair, A., 1 Dec 2019, In : Nature Communications. 10, 1, 3351.

Research output: Contribution to journalComment / DebateOtherpeer-review

Open Access

CiIIder: A tool for predicting and analysing transcription factor binding sites

Gearing, L. J., Cumming, H. E., Chapman, R., Finkel, A. M., Woodhouse, I. B., Luu, K., Gould, J. A., Forster, S. C. & Hertzog, P. J., 4 Sep 2019, In : PLoS ONE. 14, 9, 12 p., e0215495.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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1 Citation (Scopus)

Cisplatin- and cyclophosphamide-induced primordial follicle depletion is caused by direct damage to oocytes

Nguyen, QN., Zerafa, N., Liew, J., Findlay, J. K., Hickey, M. & Hutt, K., 1 Aug 2019, In : Molecular Human Reproduction. 25, 8, p. 433-444 12 p.

Research output: Contribution to journalArticleResearchpeer-review

6 Citations (Scopus)

Combined PPARγ Activation and XIAP Inhibition as a Potential Therapeutic Strategy for Ovarian Granulosa Cell Tumors

Leung, D. T. H., Nguyen, T., Oliver, E. M., Matti, J., Alexiadis, M., Silke, J., Jobling, T. W., Fuller, P. J. & Chu, S., 1 Feb 2019, In : Molecular Cancer Therapeutics. 18, 2, p. 364-375 12 p.

Research output: Contribution to journalArticleResearchpeer-review

4 Citations (Scopus)

Comparative metabolomics and transcriptomics reveal multiple pathways associated with polymyxin killing in pseudomonas aeruginosa

Han, M-L., Zhu, Y., Creek, D. J., Lin, Y-W., Gutu, A. D., Hertzog, P., Purcell, T., Shen, H-H., Moskowitz, S. M., Velkov, T. & Li, J., 1 Jan 2019, In : mSystems. 4, 1, 18 p., e00149-18.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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4 Citations (Scopus)

Complete genome sequence of Helicobacter pylori B128 7.13 and a single-step method for the generation of unmarked mutations

Dawson, E. M., Dunne, K. A., Richardson, E. J., Praszkier, J., Alfawaz, D., Woelfel, S., De Paoli, A., Chaudhry, H., Henderson, I. R., Ferrero, R. L. & Rossiter, A. E., 1 Aug 2019, In : Helicobacter. 24, 4, 10 p., e12587.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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DDX5 plays essential transcriptional and post-transcriptional roles in the maintenance and function of spermatogonia

Legrand, J. M. D., Chan, A. L., La, H. M., Rossello, F., Anko, M-L., Fuller-Pace, F. V. & Hobbs, R., 1 Dec 2019, In : Nature Communications. 10, 1, 21 p., 2278.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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4 Citations (Scopus)

Deleting Suppressor of Cytokine Signaling-3 in chondrocytes reduces bone growth by disrupting mitogen-activated protein kinase signaling

Liu, X., D'Cruz, A. A., Hansen, J., Croker, B. A., Lawlor, K. E., Sims, N. A. & Wicks, I. P., Oct 2019, In : Osteoarthritis and Cartilage. 27, 10, p. 1557-1563 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Effect of spontaneous breathing on umbilical venous blood flow and during delayed cord clamping in preterm lambs

Brouwer, E., Te Pas, A. B., Polglase, G. R., McGillick, E. V., Böhringer, S., Crossley, K. J., Rodgers, K., Blank, D., Yamaoka, S., Gill, A. W., Kluckow, M. & Hooper, S. B., 2 Apr 2019, (Accepted/In press) In : Archives of Disease in Childhood: Fetal and Neonatal Edition. 7 p.

Research output: Contribution to journalArticleResearchpeer-review

2 Citations (Scopus)

Elevated protease HtrA4 in the maternal circulation of preeclampsia may contribute to endothelial barrier disruption by cleaving key junctional protein VE-cadherin

Tseng, E., Yee Teoh, S. S., Wang, Y. & Nie, G., 15 Jan 2019, In : Placenta. 76, 15, p. 51-53 3 p.

Research output: Contribution to journalArticleResearchpeer-review

Fetal growth restriction alters cerebellar development in fetal and neonatal sheep

Yawno, T., Sutherland, A. E., Pham, Y., Castillo-Melendez, M., Jenkin, G. & Miller, S., 22 May 2019, In : Frontiers in Physiology. 10, MAY, 12 p., 560.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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1 Citation (Scopus)

From parts lists to functional significance—RNA–protein interactions in gene regulation

Kilchert, C., Sträßer, K., Kunetsky, V. & Änkö, M. L., 28 Dec 2019, (Accepted/In press) In : Wiley Interdisciplinary Reviews: Water. 20 p., e1582.

Research output: Contribution to journalReview ArticleResearchpeer-review

High levels of HtrA4 detected in preeclamptic circulation may disrupt endothelial cell function by cleaving the main VEGFA receptor KDR

Wang, Y., La, M., Pham, T., Lovrecz, G. O. & Nie, G., 1 Apr 2019, In : FASEB Journal. 33, 4, p. 5058-5066 9 p.

Research output: Contribution to journalArticleResearchpeer-review

3 Citations (Scopus)

HtrA1 alters endothelial tube formation characteristics in an in vitro model

Singh, H. & Nie, G., 2019, (Accepted/In press) 15 p. bioRxiv.

Research output: Other contributionOther

HtrA4 may play a major role in inhibiting endothelial repair in pregnancy complication preeclampsia

Wang, Y., Lim, R. & Nie, G., 1 Dec 2019, In : Scientific Reports. 9, 1, 14 p., 2728.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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1 Citation (Scopus)

Interleukin 1 Up-regulates MicroRNA 135b to Promote Inflammation-Associated Gastric Carcinogenesis in Mice

Han, T. S., Voon, D. C. C., Oshima, H., Nakayama, M., Echizen, K., Sakai, E., Yong, Z. W. E., Murakami, K., Yu, L., Minamoto, T., Ock, C. Y., Jenkins, B. J., Kim, S. J., Yang, H. K. & Oshima, M., 1 Mar 2019, In : Gastroenterology. 156, 4, p. 1140-1155.e4 20 p.

Research output: Contribution to journalArticleResearchpeer-review

10 Citations (Scopus)

Interplay between Follistatin, Activin A, and BMP4 Signaling Regulates Postnatal Thymic Epithelial Progenitor Cell Differentiation during Aging

Lepletier, A., Hun, M. L., Hammett, M. V., Wong, K., Naeem, H., Hedger, M., Loveland, K. & Chidgey, A. P., 25 Jun 2019, In : Cell Reports. 27, 13, p. 3887–3901–e4 19 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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3 Citations (Scopus)

Investigation of activin A in inflammatory responses of the testis and its role in the development of testicular fibrosis

Kauerhof, A. C., Nicolas, N., Bhushan, S., Wahle, E., Loveland, K. A., Fietz, D., Bergmann, M., Groome, N. P., Kliesch, S., Schuppe, H-C., Pilatz, A., Meinhardt, A., Hedger, M. P. & Fijak, M., 24 Jul 2019, (Accepted/In press) In : Human Reproduction. 15 p.

Research output: Contribution to journalArticleResearchpeer-review

Low Serum Levels of HtrA3 at 15 Weeks of Gestation Are Associated with Late-Onset Preeclampsia Development and Small for Gestational Age Birth

Teoh, S. S. Y., Wang, Y., Li, Y., Leemaqz, S. Y. L., Dekker, G. A., Roberts, C. T. & Nie, G., 3 Apr 2019, (Accepted/In press) In : Fetal Diagnosis and Therapy. 10 p.

Research output: Contribution to journalArticleResearchpeer-review

1 Citation (Scopus)

Lupeol, the major compound of the dichloromethane extract of Millettia macrophylla Benth (Fabaceae), displays estrogenic effects in ovariectomized rats

Zingue, S., Ntsa, D. M., Magne Nde, C. B., Michel, T., Ndinteh, D. T., Clyne, C. & Njamen, D., 1 Apr 2019, In : Phytotherapy Research. 33, 4, p. 949-957 9 p.

Research output: Contribution to journalArticleResearchpeer-review

1 Citation (Scopus)

Macrophages, rather than DCs, are responsible for inflammasome activity in the GM-CSF BMDC model

Erlich, Z., Shlomovitz, I., Edry-Botzer, L., Cohen, H., Frank, D., Wang, H., Lew, A. M., Lawlor, K. E., Zhan, Y., Vince, J. E. & Gerlic, M., Apr 2019, In : Nature Immunology. 20, 4, p. 397-406 10 p.

Research output: Contribution to journalLetterResearchpeer-review

11 Citations (Scopus)

Measurement of Mitochondrial Membrane Potential with the Fluorescent Dye Tetramethylrhodamine Methyl Ester (TMRM)

Creed, S. & McKenzie, M., 1 Jan 2019, In : Methods in Molecular Biology. 1928, p. 69-76 8 p.

Research output: Contribution to journalArticleOtherpeer-review

4 Citations (Scopus)

Menstrual fluid factors facilitate tissue repair: identification and functional action in endometrial and skin repair

Evans, J., Infusini, G., McGovern, J., Cuttle, L., Webb, A., Nebl, T., Milla, L., Kimble, R., Kempf, M., Andrews, C. J., Leavesley, D. & Salamonsen, L. A., 1 Jan 2019, In : FASEB Journal. 33, 1, p. 584-605 22 p.

Research output: Contribution to journalArticleResearchpeer-review

2 Citations (Scopus)

MicroRNA from a 12-h versus 20-h acetylcysteine infusion for paracetamol overdose

Wong, A., Nejad, C., Gantier, M., Choy, K. W., Doery, J. & Graudins, A., 1 Jun 2019, In : Human and Experimental Toxicology. 38, 6, p. 646-654 9 p.

Research output: Contribution to journalArticleResearchpeer-review

2 Citations (Scopus)

miRNA length variation during macrophage stimulation confounds the interpretation of results: implications for miRNA quantification by RT-qPCR

Pillman, K. A., Goodall, G. J., Bracken, C. P. & Gantier, M. P., 1 Feb 2019, In : Rna-A Publication of the Rna Society. 25, 2, p. 232-238 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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2 Citations (Scopus)

More than 18,000 effectors in the Legionella genus genome provide multiple, independent combinations for replication in human cells

Gomez-Valero, L., Rusniok, C., Carson, D., Mondino, S., Pérez-Cobas, A. E., Rolando, M., Pasricha, S., Reuter, S., Demirtas, J., Crumbach, J., Descorps-Declere, S., Hartland, E. L., Jarraud, S., Dougan, G., Schroeder, G. N., Frankel, G. & Buchrieser, C., 5 Feb 2019, In : Proceedings of the National Academy of Sciences. 116, 6, p. 2265-2273 9 p.

Research output: Contribution to journalArticleResearchpeer-review

22 Citations (Scopus)

Most clinical anti-EGFR antibodies do not neutralize both wtEGFR and EGFRvIII activation in glioma

Greenall, S. A., McKenzie, M., Seminova, E., Dolezal, O., Pearce, L. A., Bentley, J. D., Kuchibhotla, M., Chen, S. C., McDonald, K. L., Kornblum, H. I., Endersby, R., Adams, T. E. & Johns, T., Aug 2019, In : Neuro-Oncology. 21, 8, p. 1016-1027 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Mutational landscape of ovarian adult granulosa cell tumors from whole exome and targeted TERT promoter sequencing

Alexiadis, M., Rowley, S. M., Chu, S., Leung, D. T. H., Stewart, C. J. R., Amarasinghe, K. C., Campbell, I. G. & Fuller, P. J., 1 Jan 2019, In : Molecular Cancer Research. 17, 1, p. 177-185 9 p.

Research output: Contribution to journalArticleResearchpeer-review

3 Citations (Scopus)

Nod-like receptors are critical for gut–brain axis signalling in mice

Pusceddu, M. M., Barboza, M., Keogh, C. E., Schneider, M., Stokes, P., Sladek, J. A., Kim, H. J. D., Torres-Fuentes, C., Goldfild, L. R., Gillis, S. E., Brust-Mascher, I., Rabasa, G., Wong, K. A., Lebrilla, C., Byndloss, M. X., Maisonneuve, C., Bäumler, A. J., Philpott, D. J., Ferrero, R. L., Barrett, K. E. & 2 others, Reardon, C. & Gareau, M. G., 15 Dec 2019, In : The Journal of Physiology. 597, 24, p. 5777-5797 21 p.

Research output: Contribution to journalArticleResearchpeer-review

1 Citation (Scopus)